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Improving Education On Routine Echocardiograms In Reducing Right Sided Heart Failure When Managing Vv- Ecmo Patients, Ashley Williams Jan 2024

Improving Education On Routine Echocardiograms In Reducing Right Sided Heart Failure When Managing Vv- Ecmo Patients, Ashley Williams

DNP Projects

Background: Patients who are placed on veno- venous extracorporeal membrane oxygenation (VV- ECMO) are at high risk for developing right sided heart failure. An echocardiogram is essential for diagnostics and recovery in ECMO patients and should be a standard of care when managing this patient population. More research is needed to understand the effect of reducing right sided heart failure using routine echocardiograms. Purpose: The purpose of this study is to evaluate if there is a significant difference in outcomes of VV- ECMO patients who received routine echocardiograms compared to those who did not, and appropriately manage once RV dysfunction …


The Effects Of Yoga On Anxiety And Sleep Quality Levels Among College Students, Larisa Lucas Mullins Jan 2024

The Effects Of Yoga On Anxiety And Sleep Quality Levels Among College Students, Larisa Lucas Mullins

DNP Projects

Background: College students have poor sleep quality due to a newfound sense of freedom, exposure to new influences, or poor sleep hygiene (Dinis & Barganca, 2018). Specifically, evidence supports a correlation between sleep latency in onset or lack of nighttime sleep and increased anxiety (Dinis & Barganca, 2018). Yoga has been shown to decrease anxiety, stress symptoms, and depression (Mullen et al., 2021). Teaching yoga techniques and encouraging routine yoga practice to college students may improve sleep quality and decrease anxiety.

Purpose: This project's purpose was to evaluate the effect of yoga education and videos on sleep quality and …


Enhancing Communication Between Nurses And First Call Providers Using A Secure Chat Algorithm, Karen Hilt Jan 2024

Enhancing Communication Between Nurses And First Call Providers Using A Secure Chat Algorithm, Karen Hilt

DNP Projects

BACKGROUND: Healthcare requires quality multidisciplinary communication for patient care. Secure Chat is a feature within the Epic electronic health record to facilitate communication without violating Health Insurance Portability and Accountability Act (HIPPA). An algorithm to streamline communication utilizing this feature is needed to improve patient care.

PURPOSE: The purpose of this study was to determine, develop, implement, and evaluate a communication protocol between nurses and first call providers. The overall goal was to improve the knowledge, attitudes, efficacy, and address barriers with communication of nursing staff and providers through efficient messaging embedded within Epic, electronic health record

CONCEPTUAL MODEL: …


Electroconvulsive Therapy: Improving Psychiatric Rn Knowledge And Attitudes Using An Educational Module, Garrett Payne Jan 2024

Electroconvulsive Therapy: Improving Psychiatric Rn Knowledge And Attitudes Using An Educational Module, Garrett Payne

DNP Projects

Abstract

Background: Electroconvulsive Therapy (ECT) is a robust, versatile treatment option for many psychiatric disorders and diseases, but systemic low levels of knowledge and negative attitudes exist towards the procedure among healthcare workers, specifically among psychiatric RNs. The negative attitudes surrounding ECT are most attributable to a misunderstanding of its uses, efficacy, procedures, and safety. Psychiatric RNs hold more negative beliefs and misconceptions about ECT than any other group of healthcare workers who directly care for patients receiving the treatment. Psychiatric RNs also demonstrate poor understanding of ECT treatment procedures and outcomes. Current evidence-based practice shows that providing psychiatric RNs …


Nurse Management Competency Training For Frontline Nurse Leaders, Travis Drake Jan 2024

Nurse Management Competency Training For Frontline Nurse Leaders, Travis Drake

DNP Projects

Background: Growing evidence shows that front line nurse leaders take on their role with minimal education and training. Healthcare facilities are pressed for resources and time to allow for proper development of these leaders.

Purpose: The purpose of this project was to provide novice nurse leaders with a condensed management development program utilizing key American Organization of Nurse Leaders (AONL) nurse manager competencies. This abbreviated program was developed focusing on three key competencies of finance, innovation, and human resources. The impact of the program was measured by comparing self-assessment prior to any of the education and after the entire program …


An Educational Intervention To Improve Neonatal Icu Nurses’ Breastfeeding Support Knowledge, Self-Efficacy, And Breastfeeding Rates At Discharge, Sarah Money Jan 2024

An Educational Intervention To Improve Neonatal Icu Nurses’ Breastfeeding Support Knowledge, Self-Efficacy, And Breastfeeding Rates At Discharge, Sarah Money

DNP Projects

Background: The benefits of breastfeeding for both mother and baby are known. It is recommended that all infants be exclusively breastfed until six months (Meek & Noble, 2022; North et al., 2021). Despite this, breastfeeding rates remain low, especially in medically fragile infants requiring care in the neonatal intensive care unit (NICU) (Rollins et al., 2016). Receipt of evidence-based breastfeeding support by healthcare providers has been shown to improve breastfeeding success; however, many healthcare providers report not being comfortable or knowledgeable enough to offer support consistently (Mulcahy et al., 2022; Rollins et al., 2016).

Purpose: This study aims …


Evaluation Of Winter Cereal Cover Crops Across Nitrogen Management Strategies In No-Till Corn Production, Robert Nalley Jan 2024

Evaluation Of Winter Cereal Cover Crops Across Nitrogen Management Strategies In No-Till Corn Production, Robert Nalley

Theses and Dissertations--Plant and Soil Sciences

Rye (Secale cereale L.) is the most popular winter cereal cover crop utilized before corn, but wheat (Triticum aestivum L.) and barley (Hordeum vulgare L.) may provide a comparable value due to their similar fibrous root systems. Despite the benefits associated with winter cereal cover crops, drawbacks are possible for the subsequent corn crop. A field study was conducted with three site-years in Kentucky to measure the impact of the three winter cereals across nitrogen (N) management strategies. Wheat produced the most biomass compared with barley or rye cover crops. Wheat and rye needed approximately 100 more …


From Code To Crops: Harnessing Bioinformatics And Artificial Intelligence (Ai) In Agricultural Omics, Lakshay Anand Jan 2024

From Code To Crops: Harnessing Bioinformatics And Artificial Intelligence (Ai) In Agricultural Omics, Lakshay Anand

Theses and Dissertations--Plant and Soil Sciences

Global agricultural faces numerous challenges, such as climate change, resource limitations, novel pests and diseases, increasing costs, and the ever-increasing human population. To tackle these challenges, we need innovative strategies that combine new technologies and data analytics approaches to enhance agricultural output, promote sustainable methods, and optimize resource allocation. The key to this innovation lies in understanding the complex molecular web within plants that governs their growth, defense, and adaptability mechanisms. By mastering this molecular network, we can cultivate crops that are more resilient, sustainable, and suitable for different climatic terrains. Moreover, studying the symbiotic relationship between plants and microorganisms …


The Effects Of Potassium Fertilization Regime On High Tunnel Tomato Production, Sapana Pandey Jan 2024

The Effects Of Potassium Fertilization Regime On High Tunnel Tomato Production, Sapana Pandey

Theses and Dissertations--Plant and Soil Sciences

A two-year field experiment (2022-2023) was conducted at the University of Kentucky Horticulture Research Farm in Lexington, KY to study the effects of potassium (K2O) fertilization rates on tomato yield and ripening disorders in determinate and indeterminate varieties (‘BHN-589’ and ‘Big Beef’, respectively). In the first year, K2O rates representing the soil test result-based commercial recommendation (0 lbs/acre) and sequentially greater rates (150, 300, and 450 lbs K2O/acre) were applied. In the second year, K2O rates were increased based on lack of fruit quality response and were 0, 300, 600, and 900 lbs K2O/acre. Leaf tissue nutrients, tomato yield, and …


Surveys, Field Studies, And Laboratory Incubation Experiments To Improve Alfalfa Production In The Mid-South, William Fleming Jan 2024

Surveys, Field Studies, And Laboratory Incubation Experiments To Improve Alfalfa Production In The Mid-South, William Fleming

Theses and Dissertations--Plant and Soil Sciences

The objective of the alfalfa survey was to determine the role of soil fertility in the alfalfa yield plateau. Soil samples at depths of 10, 15, and 30 cm and tissue samples were collected from 114 alfalfa stands across Kentucky and surrounding states. Results indicate that soil fertility is likely contributing but not driving the alfalfa yield plateau. The main objective of the polyhalite incubation study is to determine if POLY4 was soluble enough to support potassium (K) and sulfur (S) for plant growth. The design of the study included four fertilizer treatments, three soil types, and four incubation times. …


Identifying Physiological, Morphological, And Genetic Drivers Of Key Intermediary Phenotypic Traits Associated With Stalk Lodging Resistance Within Genetically Diverse Maize Germplasm And Sorghum, Norbert Bokros Jan 2024

Identifying Physiological, Morphological, And Genetic Drivers Of Key Intermediary Phenotypic Traits Associated With Stalk Lodging Resistance Within Genetically Diverse Maize Germplasm And Sorghum, Norbert Bokros

Theses and Dissertations--Plant and Soil Sciences

Maize stalk lodging reduces grain yields due to the permanent breakage or deformation of stalk tissue before grain harvest. To reveal new insights into the complex problem of maize stalk lodging, this dissertation will examine three primary objectives. First, the direct, diurnal influence of turgor pressure will be shown to have only marginal effects on stalk bending strength, a key trait associated with stalk lodging resistance. Up to a dozen individual stalks, grown to physiological maturity within the same field, were tested using a DARLING testing device. In parallel, stalk turgor status as measured by leaf water potential and turgor …


The Effect Of Spring And Winter Killed Cover Crops On Soil Physical Properties And Soil Organic Carbon, Danielle Doering Jan 2024

The Effect Of Spring And Winter Killed Cover Crops On Soil Physical Properties And Soil Organic Carbon, Danielle Doering

Theses and Dissertations--Plant and Soil Sciences

Maintaining soil organic carbon (SOC) and healthy soil physical structure in agroecosystems is crucial to sustainable production. To assess medium term impacts of cover crops on soil health in the top 90 cm, we conducted a field experiment in central Kentucky with varying levels of winter cover: spring and winter kill cover crops, weedy and bare winter fallows. After eight years of cover crop use, some soil physical properties improved: 35% greater mean weight aggregate diameter at 0-30 cm with spring kill covers and 5.2% more C held within large aggregates for both cover crop treatments compared to winter fallow. …


The Roles Of Mrna Polyadenylation Factors In Plant Growth And Development, Lichun Zhou Jan 2024

The Roles Of Mrna Polyadenylation Factors In Plant Growth And Development, Lichun Zhou

Theses and Dissertations--Plant and Soil Sciences

Messenger RNA polyadenylation, the process wherein the primary RNA polymerase II transcript is cleaved and a poly(A) tract added, is a key step in the expression of genes in plants. Polyadenylation is mediated by a complex (the polyadenylation complex, or PAC) that consists of between 15 and 20 subunits. To learn the roles of PAC in regulation of the polyadenylation in plants, I conducted a survey of variability in the plant PAC. For this, I drew upon a database of naturally-occurring variation in numerous geographic isolates of Arabidopsis thaliana. The results show that many subunits of the PAC are …


Silicon Fertilization In Cool-Season Turfgrasses, Cheng Qian Jan 2024

Silicon Fertilization In Cool-Season Turfgrasses, Cheng Qian

Theses and Dissertations--Plant and Soil Sciences

Previous studies of the benefits of silicon (Si) supplementation in turfgrass have yielded inconsistent results. This dissertation aimed to assess the benefits if Si supplementation in cool-season turfgrass under more well controlled conditions than many previous studies. The first study assessed the effect of Si supplementation on biomass production and Si accumulation of tall fescue (Festuca arundinacea) and bentgrass (Agrostis stolonifera) in buffered Hoagland’s media (pH 6) with four sodium silicate (Na2SiO3) treatments (0, 0.5, 1, 2, and 4 mM Si). The two species responded differently to Si supplementation in terms of biomass. Bentgrass biomass was …


Utilizing Mixed Methods To Examine Black Graduate Students’ Experiences With Multicultural Supervision In School Psychology, Larraine Graham Jan 2024

Utilizing Mixed Methods To Examine Black Graduate Students’ Experiences With Multicultural Supervision In School Psychology, Larraine Graham

Theses and Dissertations--Educational, School, and Counseling Psychology

Multicultural supervision is essential in preparing psychologists-in-training to provide ethical, multiculturally competent practices to diverse populations. In the field of school psychology, Black graduate students remain underrepresented despite increasing diversity in schools. While there are many resources for establishing best practices in multicultural supervision in related fields, there is a lack of literature in school psychology, especially that examines Black graduate students’ experiences. Therefore, the purpose of the current study is to attend to the gap in the literature and better understand Black graduate students’ experiences with the supervisory relationship, satisfaction with supervision, and multicultural competency skill development. The current …


Building Children's Connection To Nature In The Schools: A Piloted Nature-Based Intervention, Alexis Bird Jan 2024

Building Children's Connection To Nature In The Schools: A Piloted Nature-Based Intervention, Alexis Bird

Theses and Dissertations--Educational, School, and Counseling Psychology

Nature-based interventions (NBI) have demonstrated positive effects on a range of student outcomes, including enhanced prosocial behaviors, decreased levels of stress, and improved mood and concentration. Further, school-aged children’s participation in NBIs supports students’ reconnection with the natural world. Although schools represent an ideal setting to engage students from diverse backgrounds in NBI activities, existing research is limited in understanding the effects and feasibility of integrating NBIs within school settings. This study aimed to explore the effects of NBI activities administered within a school program on students’ sense of connectedness with nature and their overall wellbeing. Additionally, participants were interviewed …


Functionalized Microfiltration Membranes For Aerosol Capture To Chloro-Organic Degradation, Rollie George Mills Jan 2024

Functionalized Microfiltration Membranes For Aerosol Capture To Chloro-Organic Degradation, Rollie George Mills

Theses and Dissertations--Chemical and Materials Engineering

The environmental remediation of water and air sources is a challenging field, due to widespread contamination, pollutant variety, and efficiency of existing treatment options. Remediation of certain pollutants, such as per- and polyfluorinated chemicals (PFAS), polychlorinated biphenyls (PCBs), volatile organic compounds (VOCs), and viral aerosols, has shown promise via adsorptive, degradative, or filtration-based processes, each with their respective advantages and limitations. Membrane technology is one option that has exhibited considerable pollutant removal from environmental sources via reverse osmosis (RO) filtration, but is limited by low permeabilities and lack of pollutant detoxification. With the support of NIEHS and NSF, the functionalization …


Molecular Understanding And Design Of Deep Eutectic Solvents And Proteins Using Computer Simulations And Machine Learning, Usman Lame Abbas Jan 2024

Molecular Understanding And Design Of Deep Eutectic Solvents And Proteins Using Computer Simulations And Machine Learning, Usman Lame Abbas

Theses and Dissertations--Chemical and Materials Engineering

Hydrophobic deep eutectic solvents (DESs) have emerged as excellent extractants. A major challenge is the lack of an efficient tool to discover DES candidates. Currently, the search relies heavily on the researchers’ intuition or a trial-and-error process, which leads to a low success rate or bypassing of promising candidates. DES performance depends on the heterogeneous hydrogen bond environment formed by multiple hydrogen bond donors and acceptors. Understanding this heterogeneous hydrogen bond environment can help develop principles for designing high performance DESs for extraction and other separation applications. This work investigates the structure and dynamics of hydrogen bonds in hydrophobic DESs …


Thermomechanical Process Simulation And Quantification Of Nanoscale Precipitation Influencing Ductility And Strength During Alloy Processing, Alyssa Stubbers Jan 2024

Thermomechanical Process Simulation And Quantification Of Nanoscale Precipitation Influencing Ductility And Strength During Alloy Processing, Alyssa Stubbers

Theses and Dissertations--Chemical and Materials Engineering

Experimental process simulation and quantification of microstructure development during processing are challenging due to limitations with machinery temperature capability, inadequate resolution and sampling volume of currently available characterization techniques, and difficulty characterizing material microstructures as close to processing-relevant conditions as possible. This dissertation addresses how process simulation can be performed using Gleeble thermomechanical technologies and how microstructure development during these processing simulations can be quantified both in-situ and ex-situ.

The first portion of this dissertation demonstrates how Gleeble technologies can be applied to simulate complex material processing conditions in order to produce process-property profiles that can be used to inform …


Exploring The Effect Of Casting Solution Composition, Additives, And Casting Conditions On The Morphology And Separation Performance Of Pvdf Membranes, Rachel Kaplan Jan 2024

Exploring The Effect Of Casting Solution Composition, Additives, And Casting Conditions On The Morphology And Separation Performance Of Pvdf Membranes, Rachel Kaplan

Theses and Dissertations--Chemical and Materials Engineering

Global water scarcity and quality concerns in the past decade have led to a looming global water crisis. Polymeric membranes have emerged as a potential solution due to their modularity, operational reliability, and wide range of contaminant removal. Polyvinylidene fluoride (PVDF) is often selected as a membrane material for its enhanced chemical resistance, thermal stability, and mechanical strength. However, these membranes often require more complex fabrication methods or support materials to achieve optimum performance. Flat-sheet unsupported PVDF membranes were fabricated via nonsolvent induced phase separation. The influence of solvent, polymer composition, pore forming additives, and casting conditions were explored with …


Development Of Glutathione-Responsive Disulfide-Containing Poly(Beta-Amino Esters) With Varied Hydrophilicity And Acrylate Functionality, Anastasiia Aronova Jan 2024

Development Of Glutathione-Responsive Disulfide-Containing Poly(Beta-Amino Esters) With Varied Hydrophilicity And Acrylate Functionality, Anastasiia Aronova

Theses and Dissertations--Chemical and Materials Engineering

Smart biomaterials are becoming promising for therapeutic deliveries due to their ability to respond to changes in the environment. Redox-responsive hydrogels are a promising type of smart polymer that can swell and degrade according to cellular oxidative stress levels. Glutathione, abundant in cells, is crucial in redox-responsive biomaterials, serving as a key reactive molecule. This study explored the degradation kinetics of glutathione-responsive poly(β-amino ester) (PBAE) polymers created through a single-step Michael addition. We examined how disulfide content influences the degradation kinetics of these PBAE networks. Additionally, we investigated how the hydrophilicity and functionality of acrylate affect the degradation of disulfide-containing …


Faceting Of Tungsten Via Environmental Control Of Temperature, Pressure And Chemistry, And Evolution Of Thermionic Cathode Materials, Huanhuan Bai Jan 2024

Faceting Of Tungsten Via Environmental Control Of Temperature, Pressure And Chemistry, And Evolution Of Thermionic Cathode Materials, Huanhuan Bai

Theses and Dissertations--Chemical and Materials Engineering

Scandate cathode presents a great potential of being used as electron emitters in vacuum electron device due to its excellent emission performance. However, it is burdened by several issues, including poor emission uniformity, inadequate reproducibility, and limited lifetime, which have impeded its further industrial application. Therefore, extensive efforts and studies need to be conducted to obtain a more comprehensive understanding of scandate cathode.

W particles, as the base material, play a fundamental role in scandate cathode. Most recent experimental research has reported that the highly faceted crystallography of W grains contributes to the properties of scandate cathode. In order to …


Sustained Release Systems For Endometrial Cancer, Claire E. Rowlands Jan 2024

Sustained Release Systems For Endometrial Cancer, Claire E. Rowlands

Theses and Dissertations--Chemical and Materials Engineering

Endometrial cancer (EC) is the sixth most common cancer in women worldwide and is the most common cancer of female reproductive organs. From 2007-2016 there has been a global rise in incidence of EC of 1.3 %. Typically, EC is treated with surgery, but at later stages surgery is less effective requiring chemotherapy and/or radiation therapy. These treatment options are less effective than surgery and there are very few FDA approved chemotherapies for EC. The minuscule number of effective treatment options as well as an increase in incidence shows the need for creating improved treatments for EC. There has been …


Experimental Characterization And Quantification Of Deformation Behavior In A Porous Carbon Fiber Network, Robert N Quammen Jan 2024

Experimental Characterization And Quantification Of Deformation Behavior In A Porous Carbon Fiber Network, Robert N Quammen

Theses and Dissertations--Chemical and Materials Engineering

Due to their wide range of attractive functional properties (such as low thermal conductivity and low density) porous materials are utilized in a variety of applications. In order to characterize these properties and others, the intrinsically heterogeneous microstructures of these materials need to be taken into account. These microstructures result in interactions across multiple length scales spanning several orders of magnitude. This makes the creation of robust computational models and straight-forward predictions of mechanical properties difficult for porous materials. With this in mind, this dissertation aims to provide experimental mechanical and deformation information spanning the length scales of interest for …


Novel Precursors For Carbon Fiber Prepared By Direct Carbonization, Leah Noble Jan 2024

Novel Precursors For Carbon Fiber Prepared By Direct Carbonization, Leah Noble

Theses and Dissertations--Chemical and Materials Engineering

For decades carbon fiber-based composites have been most heavily employed in lightweight, structural applications where low density and high strength are necessary, most notably within the aerospace industry. However, the advancement of carbon fiber into a wider array of industries has largely been limited by the high financial and energetic costs associated with its manufacture. Moreover, with an increasing societal emphasis on sustainability, there is an ever-growing desire for low-energy carbon fiber production pathways. One such pathway is the conversion of precursor fiber to carbon fiber by direct carbonization, wherein the energy-intensive, pre-carbonization stabilization step is omitted from the carbonization …


Addressing The Effects Of Counterion Size On The Properties Of Electrochemically Doped Conjugated Polymers, Kyle Baustert Jan 2024

Addressing The Effects Of Counterion Size On The Properties Of Electrochemically Doped Conjugated Polymers, Kyle Baustert

Theses and Dissertations--Chemistry

Conjugated polymers (CPs) are an emerging class of materials that are attractive for many applications due to their low cost, flexibility, and ease of processing. Both chemical and electrochemical doping of CPs is done to alter important properties such as their electrical conductivities and optical absorbances. This ability to tune their properties allows for their use in devices such as organic electrochemical transistors (OECTs) for biosensing and bioelectronics, electrochromic devices for color changing windows, as well as wearable thermoelectrics to use body heat to power wearable electronics. There are several factors that can influence the properties of doped CPs including …


Single-Atom Catalysts For Electrochemical Energy Conversion: Copper Single-Atom Catalyst For Oxygen Reduction Reaction And Quantification Of Site Density By Co Stripping Voltammetry, Dawatage Perera Jan 2024

Single-Atom Catalysts For Electrochemical Energy Conversion: Copper Single-Atom Catalyst For Oxygen Reduction Reaction And Quantification Of Site Density By Co Stripping Voltammetry, Dawatage Perera

Theses and Dissertations--Chemistry

Fuel cells are considered a promising technology for achieving cleaner and more sustainable energy production and utilization. However, one of the current major challenges is the economic viability associated with the extensive use of Pt group metal (PGM) catalysts, particularly on the cathode side. Therefore, non-PGM single-atom catalysts (SACs) have received considerable attention as alternatives for PGM catalysts in the oxygen reduction reaction (ORR), which occurs at the cathode of the fuel cell. Among various SAC structures, the non-PGM/nitrogen-doped carbon-based structure (M-N-C) stands out for its excellent ORR performance.

Chapter 2 illustrates the use of copper metal in place of …


Effect Of Π-Conjugated Ligands And A* Site Organic Cations On The Energetic Properties And Photovoltaic Performance Of Metal Halide Perovskites, Harindi R. Atapattu Jan 2024

Effect Of Π-Conjugated Ligands And A* Site Organic Cations On The Energetic Properties And Photovoltaic Performance Of Metal Halide Perovskites, Harindi R. Atapattu

Theses and Dissertations--Chemistry

Metal halide perovskites have gained interest in optoelectronic applications such as photovoltaics, lasers, LEDs, transistors, and photodetectors due to their excellent semiconducting properties considering their low cost. Metal halide perovskite (HP) photovoltaics have rapidly increased in power conversion efficiency (PCE), which now exceeds 25%. HPs have gained attention in these applications due to their high tolerance towards defects, long charge carrier diffusion lengths, high charge carrier mobility, high optical absorption, and bandgaps that are tunable over a large range. Even though HP photovoltaic PCEs are improved these are still not commercially available due to them showing lower stability and energy …


Understanding Of Processing Additives Influence In Tin Halide Perovskites: Chemistry, Defect, And Photovoltaic Performance, Syed Rahmath Ullah Joy Jan 2024

Understanding Of Processing Additives Influence In Tin Halide Perovskites: Chemistry, Defect, And Photovoltaic Performance, Syed Rahmath Ullah Joy

Theses and Dissertations--Chemistry

Metal halide perovskite semiconductors have attracted much interest for various applications, such as solar cells, light emitting diodes, photodetectors, and lasers, due to their excellent optoelectronic properties. Photovoltaic cell development is centered on Pb-based perovskites, which have equal photovoltaic performance compared to the traditional silicon photovoltaic. But concerns arising from the usage of toxic lead metal have motivated the research community to seek an alternative derivative. Among those, tin halide perovskites show much promise as an alternative to Pb-counterparts due to their ideal bandgap for single junction photovoltaics and similar optoelectronic properties to Pb perovskites. Nevertheless, tin perovskites suffer from …


Synthetic Strategies Toward The Development Of Stable Gold-Based Anticancer Agents And Their Mechanistic Insight, Adedamola Arojojoye Jan 2024

Synthetic Strategies Toward The Development Of Stable Gold-Based Anticancer Agents And Their Mechanistic Insight, Adedamola Arojojoye

Theses and Dissertations--Chemistry

Despite notable advancements in the design and synthesis of novel chemotherapeutic drugs, cancer continues to be a leading cause of death in the United States. Metallodrugs, especially Au complexes, have played a prominent role in the search for the next generation of chemotherapeutic agents. Herein, I report on the synthetic strategies towards the rational design of stable Au (Au)-based agents, study their reactivity in biological environment, and offer insights into the cytotoxic mechanism of action in cancer. Chemotherapeutic Au compounds exist mainly in +I or +III oxidation states. Repurposing of the Au(I) FDA approved auranofin for the treatment of diseases …