Digital Commons Network^™

Role Of Social Determinants Of Health And The Renin- Angiotensin Aldosterone System In Risk For Hypertensive Disorders Of Pregnancy And Related Adverse Outcomes., Esther Letushila Ndashaala

Theses and Dissertations--Nutrition and Food Systems

Background: Hypertensive disorders of pregnancy (HDP) represent a significant public health issue, contributing to maternal and fetal morbidity and mortality. Women from lower socioeconomic backgrounds or marginalized racial and ethnic groups face higher risks of HDP, which have been incompletely described. In addition, risk for HDP may be linked to a reduction in the normal activity of the renin-angiotensin-aldosterone system (RAAS). This study investigates the role of socioeconomic factors and RAAS components in the risk for HDP and adverse maternal and neonatal outcomes. Methods: This study is a secondary analysis of data from 180 pregnant individuals from a high-risk maternal-fetal …

Influencers Of Fidelity In Implementation Of Go Napsacc At Selected Early Childhood Education Centers In Kentucky, Adeyimika Desmennu

Theses and Dissertations--Nutrition and Food Systems

Several lifestyle interventions have been explored to ameliorate obesity and most associated non-communicable diseases in children attending early childhood education settings (ECE). Go Nutrition and Physical Activity Self-Assessment for Child Care (NAPSACC) program has been implemented nationally to improve dietary intake and physical activities among children in ECE settings. However, a large proportion of ECE centers do not complete the five-step process that leads to change. This project, thus, aims to identify contextual factors that facilitate and/or impede the fidelity in implementation of Go NAPSACC.

This thesis is a comparative case study using secondary data to compare, and contrast reported …

Evaluation Of Ten Alternative Treatments For The Management Of Harlequin Bug (Murgantia Histrionica) On Brassica Crops, Sarah Clark

Theses and Dissertations--Entomology

This thesis investigates the efficacy of exclusion netting and selected biopesticides in controlling the common brassica pest harlequin bug (Murgantia histrionica); it assesses the phytotoxic effects caused by selected essential oil products; and it evaluates whether selected treatments caused mortality in common beneficial insects. This is one of the first studies to investigate the potential pest controlling properties of commercially produced bokashi fermented composting products as well as their effect on natural enemies.

During both the first and second year of the study, none of the commercially produced essential oil products or bokashi products were effective in controlling …

Weed Management Impacts On Wild Bees In Agroecosystems, Amanda Denny

Theses and Dissertations--Entomology

In agricultural landscapes, bee communities are shaped by factors including the plant community, land management, and pesticides. These factors are critical in the late winter and early spring (LWES) when floral resources are scarce and many bee species are becoming active. In this dissertation, I characterize the flowering weed community of Central Kentucky agroecosystems in the LWES, examine the response of wild bee communities to the total cover and diversity of these flowering plants, and assess the risks of glyphosate exposure on developing ground nesting bees. I found that the flowering plant community was similar across land cover types and …

Assessing Endophyte Frequency Distributions And The Effect Of Epichloë Brachyelytri In The Chemotypic And Genotypic Diversity Of Brachyelytrum Erectum, Rachel Ann Sneed

Theses and Dissertations--Plant Pathology

Seed-transmissible epichloid fungal endophytes are best known for their roles as defensive mutualists in cool-season grasses. Historically, the discovery of fungal endophytes was driven by investigations of plant toxicity to livestock, followed by extensive study of their alkaloids and protection against insects and nematodes. Epichloae can produce four classes of alkaloids: ergot alkaloids, lolines (saturated aminopyrrolizidines), indole–diterpenes, and peramine. It is increasingly evident that these hereditary symbionts have much more diverse chemical profiles both in individual populations and between them. To this end, differences in chemotypic profiles of these symbionts may translate to different evolutionary and environmental advantages across plant …

Role Of Autophagy-Related Genes In Lipid Transport For Efficient Replication Of Tombusviruses, Yuanrong Kang

Theses and Dissertations--Plant Pathology

Tombusviruses are positive-strand RNA viruses, which utilize numerous co-opted host factors and massive de-novo synthesized membrane resources to modify host membranes and form large viral replication organelles (VROs). Among plenty of host cellular processes, autophagy emerges as a potential membrane resource for VROs formation due to its ability to de-novo generate the double membrane structures, known as autophagosomes. Besides, as an important host defense pathway, autophagy is also a target for tombusviruses to prevent its antiviral activities. In this study, I identify the role of key autophagy related genes, Atg11, Atg8, and Atg2, which are involved in autophagosome formation, and …

Systemic Signaling In Plants: Role Of Cuticle, Salicylic Acid, Rna, And Vitamins, Huazhen Liu

Theses and Dissertations--Plant Pathology

Systemic acquired resistance (SAR) is a form of broad-spectrum resistance induced in response to local infection that protects uninfected parts against subsequent secondary infections. Several diverse chemical signals contributing to SAR have been isolated and characterized, including glycerol-3-phosphate (G3P) and pipecolic acid (Pip), both of which play an important role in human and plant disease physiologies. In addition to these, salicylic acid (SA) also regulates SAR and normal transport of SA and G3P is required for de novo biosynthesis of Pip in the distal leaves. Pip is catabolized via multiple pathways, and this in turn regulates vitamin homeostasis. A normal …

Current And New Perspectives On Equine Protozoal Myeloencephalitis Therapeutics, Izabela De Assis Rocha

Theses and Dissertations--Veterinary Science

Equine protozoal myeloencephalitis (EPM) is an important neurologic disease of horses in the Americas. It is caused by the apicomplexan parasite Sarcocystis neurona and less commonly by the related parasite Neospora hughesi. Current antiprotozoal treatment relies on the use of either folate inhibitors (sulfadiazine/pyrimethamine) or triazine drugs (diclazuril/ponazuril), with a success rate of 60-70% regardless of the drug of choice. Successful treatment is defined as the improvement of at least one ataxia grade following the modified Mayhew scale, which often is not enough for the horse to return to the previous level of performance. The goals of this dissertation …

Impact Of Short-Distance Road Transportation On Horse Health, Erica Jacquay

Theses and Dissertations--Veterinary Science

Horses are regularly transported across the United States; however, the reasons for travel, trip lengths, and management practices are not well characterized. While long distance transportation has been associated with increased incidences of health-related problems, the impact of short distance transportation on horse health is less understood. Notably, aged horses ( > 15 years) have an altered immune response following short-distance transportation, but this has yet to be compared to young horses. It is also unknown whether transportation stress would alter endocrine responses of horses with metabolic disorders, such as insulin dysregulation (ID) or pituitary pars intermedia dysfunction (PPID).

The objectives …

Determining Population Structure In Kentucky Parascaris Univalens Specimens, Constance Finnerty

Theses and Dissertations--Veterinary Science

Parascaris univalens is a highly pathogenic nematode that affects the gastrointestinal system of young horses. When unaddressed, this parasite causes severe intestinal impactions and even death. Parascaris univalens is also found to have an emergence of anthelmintic resistances, causing a concern for horse owners. Despite its clinical significance, very little work has been done on Parascaris univalens to identify its population structure. This study aimed to determine the population structure of Parascaris univalens through Illumina next generation sequencing (NGS) on three hierarchical categorizations: within a horse, within an isolated herd, and within horses in the state of Kentucky. A total …

Genomic Studies Of The Equine Bloodworm, Strongylus Vulgaris, Nichol Ripley

Theses and Dissertations--Veterinary Science

Strongylus vulgaris is the most pathogenic nematode parasite of grazing horses worldwide. This gastrointestinal parasitic nematode is in the family Strongylidae under the subfamily Strongylinae, or Strongylins. While the epidemiology, complete life cycle, and high pathogenicity of the fourth and fifth larval stages of S. vulgaris are well established, we understand very little about its biology. This parasite is renowned for its unique life cycle and capacity to cause arterial damage, leading to significant health and economic impacts for the equine industry. It also is the most intensively documented Strongylin; however, S. vulgaris has yet to gain drug resistance as …

Temporal Changes In The Genome Of Apicomplexan Parasite Sarcocystis Neurona Sn3, Jamie Norris

Theses and Dissertations--Veterinary Science

Sarcocystis neurona is an apicomplexan parasite and the main etiologic agent behind Equine Protozoal Myeloencephalitis (EPM), the most diagnosed neurologic disease in horses living in the Americas. Technical advances that arose from the human genome project between 1990 and 2003 and the corresponding “omics” revolution in research have allowed scientists novel approaches to study organisms. Herein, we sought to leverage bioinformatic advances and new sequencing platforms to provide an improved understanding of the biology of S. neurona. At the outset of this project, reference genomes from two different S. neurona strains (SN3.e1 and So SN1) were available. A new and …

Surface Mining Interacts With Timber Harvesting To Facilitate The Invasion Of Woody Invasive Species In A Temperate Forest Of Central Appalachia, Usa, William Wittenbraker

Theses and Dissertations--Forestry and Natural Resources

Appalachian forests are subjected to various short- and long-term anthropogenic disturbances. Surface mining is among the most potent drivers of land use change in the Appalachian region, reducing native forest cover and causing landscape fragmentation. Furthermore, the ecological footprint of surface mining could be expanded to adjacent forests, and such spill-over effects may be exacerbated by in-situ forest disturbances such as timber harvesting. However, it remains elusive how these two disturbance agents may be compounded to degrade forest health and landscape integrity. One of the major threats to forest health in the Appalachian forests is the invasive species. Many woody …

Communicating Climate Change: Adaptive Silviculture In Central Appalachian Kentucky, Logan Baker

Theses and Dissertations--Forestry and Natural Resources

Climate change communication is an emerging field that requires a multidisciplinary understanding of both climate and social science. Communicating with underrepresented woodland owners about climate change, specifically climate change adaptation in forestry applications, necessitates appropriately adjusted approaches. In Central Appalachian Kentucky, outreach with underrepresented woodland owners on forest adaptation topics has not been examined in depth. The recent establishment of an Adaptive Silviculture for Climate Change research site in the University of Kentucky’s Robinson Forest has created an opportunity to generate regionally specific climate adaptation information for Appalachian Kentucky forests. It is imperative to investigate how best to approach communicating …

Dynamic Patterns Of Resource Selection In Northern Bobwhite Across The Annual Cycle In A Region With Poor Edaphic Conditions, Autumn S. Randall

Theses and Dissertations--Forestry and Natural Resources

Developing successful management strategies requires an understanding of how an organism's resource needs change over the course of its life cycle. For almost a century, northern bobwhite (Colinus virginianus) populations have been declining range-wide, mostly as a result of habitat loss and degradation. Resource selection studies conducted at coarse-temporal resolutions and in areas with fertile soils form the majority of current management recommendations for bobwhites. In this thesis, we quantified resource selection patterns for 1,302 bobwhites in a region with poor soil conditions with respect to several common management practices (fire, fallow fields, supplemental feeding, and brush management …

Manrrs Advisors And Their Perceptions Of Their Mentor Strategies, Dallas L. Cooks

Theses and Dissertations--Community & Leadership Development

Minorities in Agriculture Natural Resources and Related Sciences, also known as MANRRS, is an organization with chapters nationwide. Their main focus is to provide professional development, academic advancement, and networking to those in agriculture and related sciences. This research focuses on the advisors of MANRRS chapters across the country and at various institutions. Advisors were asked a series of questions through a Qualtrics survey about their mentor strategies with their students. Chapter Advisors were asked demographic, Likert Scale, and questions based on their personal MANRRS experience. As a result of the data, five research questions were answered. Chapter Advisors and …

"We Are The Mycelium" Exploring Mutual Aid Networks And Food System Resilience In Eastern Kentucky, Lindsey A. Windland

Theses and Dissertations--Community & Leadership Development

The effects of climate change are predicted to have a widespread impact on numerous aspects of the U.S. food system. Industrialization and consolidation within the U.S. food system have decreased the food system’s capacity for adaptation to external stressors. In recent years local food systems have demonstrated a potential for adaptation during and after disasters. More research is needed to better understand local food systems and their adaptative innovations, as a better understanding of these innovations is important for developing local food systems with strong adaptative capacities. This exploratory study examines how the local food systems of Eastern Kentucky pivoted …

Evaluating The Caring Cards Program And Its Effect On Mental Health Indicators Among A Self-Defined Agricultural Group In Rural Kentucky, Katrina Clontz

Theses and Dissertations--Community & Leadership Development

Suicide is currently the 11^th leading cause of death in the Unites States (American Foundation for Suicide Prevention, 2024), and is especially high among the farming and agricultural population (Kennedy et al., 2021; Klingelschmidt et al., 2022; Monteith et al., 2020). Additionally, mental health access and outcomes are worse among this population, partially due to the inaccessibility of care in rural areas (Taylor, 2019). Communication among caring individuals is thought to be an effective suicide prevention strategy (Long, 2023; Ross & Bassilos, 2019). The Caring Cards program was developed as a way to facilitate mental health communications among a …

Autism In Agricultural Education: A Case Study Of An Adolescent With Autism Spectrum Disorder And Their Parent On Career And Technical Education, Grace Miller

Theses and Dissertations--Community & Leadership Development

Autism spectrum disorder (ASD) is a unique and often misunderstood diagnosis. Little is known about the experiences of adolescents with ASD. As students with ASD graduate high school, many are under- and unemployed. Career and technical education (CTE) in U.S. schools is intended to prepare all students for careers post-secondary. Agricultural education is one of the predominate career clusters within CTE. This qualitative single case study sought to create a platform for both a student and their parent to share their experiences in agricultural education and CTE. Participants were an adolescent with ASD who had taken at least one year …

Exploring The Impact Of An Appalachian Higher Education Institution Had On Fostering Solidarity, Capacity, And Agency Of Female Appalachian Students Seeking To Positively Influence The Quality Of Life For Themselves And Appalachian Communities, Analiese Mitchell

Theses and Dissertations--Community & Leadership Development

Appalachian women navigating higher education encounter multifaceted challenges, often confronting marginalization and a lack of representation within academic spaces. This study investigates the experiences of female Appalachian students at Mountain University in Kentucky, aiming to shed light on their journey and the university's impact on their lives and communities. Drawing on qualitative data from interviews, the research explores themes of solidarity, capacity, agency, and Quality of Life. Findings reveal a robust sense of solidarity among Appalachian peers and faculty, fostering a supportive environment conducive to personal and academic growth. Participants express opportunities to engage with their communities positively, contributing to …

Development Of Lignin Derived Hydrophobic Deep Eutectic Solvents As Sustainable Solvents And Their Applications, Yuxuan Zhang

Theses and Dissertations--Biosystems and Agricultural Engineering

The development of green solvents is a pivotal endeavor in achieving the goals of green chemistry. Ionic liquids (ILs) and deep eutectic solvents (DESs) have emerged as promising green alternatives to conventional organic solvents due to their low toxicity, potential biodegradability, low volatility, and high tunability. Compared to ILs, DESs have attracted more attention recently as they are easier and less expensive to produce. Hydrophobic DESs (HDESs), a new generation of DESs introduced in 2015, have gained considerable interest for their ability to overcome the instability issues of traditional DESs when exposed to water. This advancement extensively broadens the application …

Implications Of Nanopesticides On Downstream Wetland Ecosystems, Kiley Power

Theses and Dissertations--Biosystems and Agricultural Engineering

Nanopesticides are thought to be a promising course of action for reducing agricultural impacts on the environment, however, little is known regarding the fate and transport of nanopesticides, specifically their influence on downstream wetland ecosystems. The objective of this study was to assess the implications of a nano-Cu fungicide (Kocide 3000) and a neonicotinoid insecticide (imidacloprid) on downstream wetland habitats, particularly their effects on wetland nutrient cycling, using fifteen mesocosm wetlands. The complex interactions between nitrogen, Kocide 3000, and imidacloprid were found to increase nitrate removal rates, decrease phosphate removal rates, and inhibit nitrogen uptake in below-ground biomass. Each treatment, …

The Characterization, Assessment, And Shear Strength Of Turfgrass Soil In North American Thoroughbred Racing, Peter Schmitt

Theses and Dissertations--Biosystems and Agricultural Engineering

Minimizing catastrophic injuries to racehorses, which also protects the riders, is critical for the future of the Thoroughbred racing industry. While the causes of catastrophic injuries are multifactorial, the condition of the racing surface is one of only a few factors that affects all horses in competition. Horse racing surfaces must retain enough shear strength to support the hoof of a Thoroughbred at a gallop. Turfgrass racing surfaces also require healthy turf to reinforce the footing while also achieving a high infiltration rate to allow races to run on the turf soon after or even during rain. This research is …

Wetland Treatment Systems For Municipal Wastewater At A Bourbon Distillery And Potential Value Of Incorporating Stillage For Water Treatment Enhancement, Katherine J. Ristola

Theses and Dissertations--Biosystems and Agricultural Engineering

The use of constructed treatment wetlands, as a secondary treatment method for wastewater effluent from package treatment plants and distillery stillage has potential to be an innovative, sustainable method for improving water quality in the Central Kentucky region. However, the use of constructed wetlands to treat stillage and wastewater treatment plant effluent has been limited. Therefore, the objectives of this study were to: 1) quantify constructed wetland removal as a secondary treatment method for distillery’s wastewater; 2) explore the potential to utilize constructed treatment wetlands to remove nutrients from bourbon stillage; and 3) optimize treatment design to meet wastewater effluent …

Utilizing Isotope Tracing To Assess Land Use Implications To Tap And Stream Water Chemistry, Katrina Alexis Mcfadden

Theses and Dissertations--Biosystems and Agricultural Engineering

Water quality is an issue that continues to be worsened by extreme flooding, specifically in Eastern Kentucky. The most recent 2022 flooding event in Eastern Kentucky resulted in loss of human life, over $23.3 billion in damaged infrastructure, and impaired human health. Infrastructure failures, such as leaky pipes, are a growing challenge in these regions as rebuilding has occurred. Therefore, the goal of this project was to evaluate water quality in two of the counties most impacted by the 2022 flood in Kentucky, Breathitt and Perry Counties, using sulfur isotopes as a novel tracer to identify potentially failures in distribution …

The Efficacy Of Wetland Treatment Systems Used To Treat Runoff Mixtures From Different Landscapes Across Kentucky, Emily Nottingham

Theses and Dissertations--Biosystems and Agricultural Engineering

The overarching goal was to improve our understanding of the cumulative effect of increased use and occurrence of commonly detected contaminants of potential concern (CPCs) on nitrogen (N) transformation processes in wetlands. The central hypothesis was that those various mixtures of nutrients and CPCs entering treatment wetlands impact N removal pathways. The first study assessed the current state of the literature on the implications to N removal in wetlands in the presence of pesticides and antibiotics. 181 primary studies were identified. Removal efficiencies for nitrate varied widely across the studies, with CPCs impacting microbial communities. A knowledge gap remains in …

Valorization Of Bourbon Distilling Waste Using Thermal Conversion Processes For Nutrient-Rich Food Products, Tosin Olayemi Olanrewaju

Theses and Dissertations--Biosystems and Agricultural Engineering

The Commonwealth of Kentucky accounts for over 95% of global bourbon production. A primary byproduct of bourbon production is stillage, which has a very high moisture content (91–94%) and high biochemical oxygen demand, making it challenging to manage. The recent expansion of the bourbon industry has heightened environmental concerns regarding the best methods to handle this byproduct. Dewatering and drying of stillage produce distillers' spent grains (DSG-B), which are rich in dietary fiber and protein and could serve as an excellent source of functional fiber in human nutrition.

This study examined the approach for dewatering, drying, inclusion of DSG-B as …

Improving Healthcare Provider Knowledge And Confidence With Treating The Lgbtq Population Through A Web-Based Education Module, Logan Price

DNP Projects

Background: There is a need for improved healthcare staff and provider knowledge and confidence when treating the LGBTQ population, as many healthcare providers are insufficiently prepared to treat LGBTQ patients (Rowe et al., 2017). This population is at greater risk for mental illness, substance use, and physical illness than the general population due to societal factors such as minority stress and stigma (Cochran et al., 2004; Cochran & Mays 2007; Cochran et al., 2003; Meyer, 2003). Purpose: The purpose of this project is to educate healthcare staff and providers about the LGBTQ population to improve their knowledge and confidence when …

Point Of Care Ultrasound (Pocus) For Advanced Practice Providers (Apps), Crystal S. Rogers

DNP Projects

Background: Advanced practice providers (APPs) routinely lack the skillset to perform Point of Care Ultrasound (POCUS) because currently, there is not a standardized curriculum within scholarly programs (Santos et al., 2018) and/or inadequate hospital training to perform these competencies (Huang et al., 2021). The absence of a standard curriculum has limited the ability of APPs to practice with full scope, provide care that is comparable to physician partners in the acute care setting, and deliver highest quality of patient care. Implementing standard education to train APPs for POCUS addresses this identified gap.

Purpose: The purpose of this project was to …

Investigating The Correlation Between Social Determinants Of Health And Drug Selling Among People Who Use Drugs In Rural Appalachia, Kentucky, Grace A. Debo

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Abstract

Aims: To identify demographic, socioeconomic, health and access to resources, and drug use correlates associated with drug selling among adult, people who use drugs (PWUD) in rural Appalachia.

Methods: This cross-sectional study analyzed survey data from the ongoing KyOSK and SNAP projects. The surveys included information on participant characteristics (demographic, socioeconomic), and health and drug use behaviors. Our analysis was restricted to only those who answered the question regarding drug selling (n=738). Both univariate and multivariate logistic regression models were employed to identify correlates of drug selling.

Results: Among 738 participants, 20.6% reported selling or attempting to sell drugs …