Digital Commons Network^™

Influence Of Oxygen Leakage Through Stretch Film On Quality Of Round Bale Silage, P Lingvall, C M. Pettersson, P Wilhelmsson

IGC Proceedings (1977-2023)

The ensiling-process is based on anaerobic conditions. Therefore, it is important to get "air tight" parcels covering big-bale silage. Wrapping round bales wilh stretch film has improved silage quality, and reduced diy matter (OM) and energy losses. In this experiment we studied the influence of stretch film quality, film thickness, .storage temperature and storage place on fermentation, microbial growth/ and DM losses. Additionally, oxygen permeability of stretch film wrapped in 4 or 6 layers around artificial bales (metal) and DM losses was tested In a model. High storage temperature, low total film thickness and high film permeability to oxygen increased …

Determining The Key Education Priorities Related To Heart Failure Care In Nursing Homes: A Modified Delphi Approach, James Mcmahon, David R. Thompson, Christine Brown Wilson, Loreena Hill, Paul Tierney, Jan Cameron, Doris S. F. Yu, Debra K. Moser, Karen Spilsbury, Nittaya Srisuk, Jos M. G. A. Schols, Mariëlle Van Der Velden-Daamen, Gary Mitchell

UK CARES Faculty Publications

There is currently a limited understanding of what nurses in nursing homes view as the key education priorities to support their ability to provide the appropriate care for residents with heart failure (HF). A modified Delphi technique was utilized to gain a consensus on the key education priorities for nurses working in nursing homes in Northern Ireland. An initial list of items (n = 58), across 19 domains, was generated using the findings of a scoping review and stakeholder interviews, and a review of available clinical guidelines. Two rounds of surveys were undertaken. Items were presented using a 5-point Likert …

Evaluation Of Roadway Reconfigurations In Louisville, Kentucky, William Staats, Adam Kirk

Kentucky Transportation Center Research Report

In 2009, Louisville Metro Public Works undertook its first roadway reconfiguration project, converting a section of Eastern Parkway (US 60A) from a four-lane undivided road to a three-lane section with a two-way left-turn lane and one travel lane in each direction. Since this initial project, Louisville Metro Public Works and the Kentucky Transportation Cabinet (KYTC) have completed 40 roadway reconfigurations to reduce the number of through lanes and reassign existing right-of-way to other roadway users. Additionally, the agencies have 25 more planned or proposed reconfiguration projects. This report documents the safety and operational performance of reconfigured roads. Across all projects, …

Forage News [2024-08], University Of Kentucky

Forage News

No abstract provided.

Asap: A Pharmacy-Level Intervention To Increase Nonprescription Syringe Sales To Reduce Bloodborne Illnesses., B. E. Meyerson, J. Agley, Richard A. Crosby, K. G. Bentele, N. Vadiei, L. B. Linde-Krieger, D. R. Russell, K. Fine, L. A. Eldridge

Health, Behavior & Society Faculty Publications

BACKGROUND: Pharmacy syringe sales are effective structural interventions to reduce bloodborne illnesses in populations, and are legal in all but two states. Yet evidence indicates reduced syringe sales in recent years. This study was designed as a feasibility test of an intervention to promote syringe sales by pharmacies in Arizona.

METHODS: A four-month pilot among three Arizona pharmacies measured feasibility and acceptability through monthly surveys to 18 enrolled pharmacy staff members.

RESULTS: Pharmacy staff reported increased ease of dispensing syringes across the study. Rankings of syringe dispensing as 'easiest' among 6 measured pharmacy practices increased from 38.9 % at baseline …

Transformation Of Organic To Inorganic Nitrogen In Nh4 +-Illite-Bearing And Ga-Al-Ree-Rich Bituminous Coals: Evidence From Nitrogen Isotopes And Functionalities, Qian Wang, Shifeng Dai, Victor P. Nechaev, David French, Ian Graham, Lei Zhao, Shaowei Zhang, Yang Liang, James C. Hower

Earth and Environmental Sciences Faculty Publications

Nitrogen is one of the most important elements and mainly occurs as organic forms in coal, and in a few cases, in an inorganic form. Organic nitrogen in coal is mainly derived from the proteins of plants and micro-organisms but sources of inorganic nitrogen remain controversial. One hypothesis for the source of inorganic nitrogen is the organic matter of coal, but this lacks strong evidence. In the Daqingshan Coalfield of Inner Mongolia, northern China, an igneous intrusion in the east of the coalfield led to a coal rank increase from the Hailiushu through the Datanhao mines to the Adaohai mine …

Fine-Scale Mangrove Species Classification Based On Uav Multispectral And Hyperspectral Remote Sensing Using Machine Learning, Yuanzheng Yang, Zhouju Meng, Jiaxing Zu, Wenhua Cai, Jiali Wang, Hongxin Su, Jian Yang

Earth and Environmental Sciences Faculty Publications

Mangrove ecosystems play an irreplaceable role in coastal environments by providing essential ecosystem services. Diverse mangrove species have different functions due to their morpho- logical and physiological characteristics. A precise spatial distribution map of mangrove species is therefore crucial for biodiversity maintenance and environmental conservation of coastal ecosystems. Traditional satellite data are limited in fine-scale mangrove species classification due to low spatial resolution and less spectral information. This study employed unmanned aerial vehicle (UAV) technology to acquire high-resolution multispectral and hyperspectral mangrove forest imagery in Guangxi, China. We leveraged advanced algorithms, including RFE-RF for feature selection and machine learning models …

Potential Impact Of Curative And Preventive Interventions Toward Hepatitis C Elimination In People Who Inject Drugs-A Network Modeling Study., Lin Zhu, William W. Thompson, Liesl Hagan, Liisa M. Randall, Abby E. Rudolph, April M. Young, Jennifer R. Havens, Joshua A. Salomon, Benjamin P. Linas

Center on Drug and Alcohol Research Faculty Publications

BACKGROUND: Injection-equipment-sharing networks play an important role in hepatitis C virus (HCV) transmission among people who inject drugs (PWID). Direct-acting antiviral (DAA) treatments for HCV infection and interventions to prevent HCV transmission are critical components of an overall hepatitis C elimination strategy, but how they contribute to the elimination outcomes in different PWID network settings are unclear.

METHODS: We developed an agent-based network model of HCV transmission through the sharing of injection equipment among PWID and parameterized and calibrated the model with rural PWID data in the United States. We modeled curative and preventive interventions at annual coverage levels of …

Buprenorphine Prescribing Characteristics Following Relaxation Of X-Waiver Training Requirements., Paul J. Christine, Rouba A. Chahine, Simeon D. Kimmel, Nicole Mack, Christian Douglas, Thomas J. Stopka, Katherine Calver, Laura C. Fanucchi, Svetla Slavova, Michelle R. Lofwall, Daniel J. Feaster, Michael Lyons, Jerel M. Ezell, Marc R. Larochelle

Center on Drug and Alcohol Research Faculty Publications

IMPORTANCE: Local-level data are needed to understand whether the relaxation of X-waiver training requirements for prescribing buprenorphine in April 2021 translated to increased buprenorphine treatment.

OBJECTIVE: To assess whether relaxation of X-waiver training requirements was associated with changes in the number of clinicians waivered to and who prescribe buprenorphine for opioid use disorder and the number of patients receiving treatment.

DESIGN, SETTING, AND PARTICIPANTS: This serial cross-sectional study uses an interrupted time series analysis of 2020-2022 data from the HEALing Communities Study (HCS), a cluster-randomized, wait-list-controlled trial. Urban and rural communities in 4 states (Kentucky, Massachusetts, New York, and Ohio) …

Associations Between Il-1Β, Il-6, And Tnfα Polymorphisms And Longitudinal Trajectories Of Cognitive Function In Non-Demented Older Adults, Karen A. Lawrence, Elana M. Gloger, Cristina N. Pinheiro, Frederick A. Schmitt, Suzanne C. Segerstrom

Neurology Faculty Publications

Inflammation is implicated in Alzheimer’s disease (AD), and specific single nucleotide polymorphisms (SNPs) in inflammatory cytokine genes are associated with increased AD risk. Whether the same polymorphisms also predict domain-specific cognitive change in cognitively healthy older adults is unclear. Specific SNPs in three cytokine genes, IL-1β (rs16944), IL-6 (rs1800795), and TNFα (rs1800629) were assessed for association with longitudinal trajectories spanning up to 16 years of global cognitive function, episodic memory, attention and working memory, and executive function in a sample of 324 non-demented older adults. Only rs1800629 (TNFα) was associated with significant change in global cognitive function over time [γ …

Enhancing Thermal Stability Of Perovskite Solar Cells Through Thermal Transition And Thin Film Crystallization Engineering Of Polymeric Hole Transport Layers, Sanggyun Kim, Sina Sabury, Carlo A. R. Perini, Tareq Hossain, Augustine O. Yusuf, Xiangyu Xiao, Ruipeng Li, Kenneth R. Graham, John R. Reynolds, Juan-Pablo Correa-Baena

Chemical and Materials Engineering Faculty Publications

Organic hole transport layers (HTLs) have been known to be susceptible to thermal stress, leading to poor long- term stability in perovskite solar cells (PSCs). We synthesized three 2,5-dialkoxy-substituted, 1,4-bis(2-thienyl)phenylene (TPT)-based conjugated polymers (CPs) linked with thiophene-based (thiophene (T) and thienothiophene (TT)) comonomers and evaluated them as HTLs in n-i-p PSCs. TPT-T (MB/C6), which has branched 2- methylbutyl and linear hexyl (MB/C6) side chains, emerged as a promising HTL candidate, enabling power conversion efficiencies (PCEs) greater than 15%. In addition, PSCs with this HTL showed an improvement in long-term stability at elevated temperatures of 65 °C when compared to those …

Data Files For Optical Imaging Provides Flowcytometry-Like Single Cell Level Analysis Of Hif-1Α Mediated Metabolic Changes In Radio-Resistant Head And Neck Squamous Carcinoma Cells, Jing Yan, Carlos Frederico Lima Goncalves, Pranto Soumik Saha, Cristina M. Furdui, Caigang Zhu

Biomedical Engineering Faculty Publications

No abstract provided.

The Impact Of Social Deprivation On Health Care Utilization Patterns Following Closed Reduction And Percutaneous Pinning Of Pediatric Supracondylar Humerus Fractures, Elizabeth Cinquegrani, Matthew Van Boxtel, Sergey Tarima, Jessica Hanley

Biostatistics Faculty Publications

Background: Disparities in social determinants of health have been linked to worse patient-reported outcomes, higher postoperative pain, and increased risk of revision surgery following orthopaedic procedures. Identification of perioperative predictors of health care utilization is of particular interest to mitigate cost and improve patient outcomes. The aim of this study is to elucidate the effect of social deprivation levels, using the Area Deprivation Index (ADI), on health care utilization following the pinning of supracondylar humerus (SCH) fractures. Identifying risk factors for discrepancies in health care utilization following SCH fracture fixation can help mitigate unnecessary health care spending and improve the …

Resolving The Size And Charge Of Small Particles: A Predictive Model Of Nanopore Mechanics, Samuel Bearden, Tigran M. Abramyan, Dmitry Gil, Jessica Johnson, Anton Murashko, Sergei Makaev, David Mai, Alexander Baranchikov, Vladimir Ivanov, Vladimir Reukov, Guigen Zhang

Chemical and Materials Engineering Faculty Publications

The movement of small particles and molecules through nanopore membranes is widespread and has far-reaching implications. Consequently, the development of mathematical models is essential for understanding these processes on a micro level, leading to deeper insights. In this endeavor, we suggested a model based on a set of empirical equations to predict the transport of substances through a solid-state nanopore and the associated signals generated during their translocation. This model establishes analytical relationships between the ionic current and electrical double-layer potential observed during analyte translocation and their size, charge, and mobility in an electrolyte solution. This framework allows for rapid …

A Practical Guide To Data Management And Sharing For Biomedical Laboratory Researchers., K Fouad, R Vavrek, M C Surles-Zeigler, J R Huie, H L Radabaugh, G G Gurkoff, U Visser, J S Grethe, M E Martone, A R Ferguson, John C. Gensel, A Torres-Espin

Physiology Faculty Publications

Effective data management and sharing have become increasingly crucial in biomedical research; however, many laboratory researchers lack the necessary tools and knowledge to address this challenge. This article provides an introductory guide into research data management (RDM), and the importance of FAIR (Findable, Accessible, Interoperable, and Reusable) data-sharing principles for laboratory researchers produced by practicing scientists. We explore the advantages of implementing organized data management strategies and introduce key concepts such as data standards, data documentation, and the distinction between machine and human-readable data formats. Furthermore, we offer practical guidance for creating a data management plan and establishing efficient data …

Cerebrovascular Reactivity Mri As A Biomarker For Cerebral Small Vessel Disease–Related Cognitive Decline: Multi-Site Validation In The Markvcid Consortium, Peiying Liu, Zixuan Lin, Kaisha Hazel, George Pottanat, Cuimei Xu, Dengrong Jiang, Jay J. Pillai, Emma Lucke, Christopher E. Bauer, Brian T. Gold, Steven M. Greenburg, Karl G. Helmer, Kay Jann, Gregory Jicha, Joel Kramer, Pauline Maillard, Rachel M. Mulavelil, Pavel Rodriguez, Claudia L. Satizabal, Kristin Schwab, Sudha Seshadri, Herpreet Singh, Ángel G. Velarde Dediós, Danny J. J. Wang, Rita R. Kalyani, Abhay Moghekar, Paul B. Rosenberg, Sevil Yasar, Marilyn Albert, Hanzhang Lu

Neurology Faculty Publications

INTRODUCTION: Vascular contributions to cognitive impairment and dementia (VCID) represent a major factor in cognitive decline in older adults. The present study examined the relationship between cerebrovascular reactivity (CVR) measured by magnetic resonance imaging (MRI) and cognitive function in a multi-site study, using a predefined hypothesis.

METHODS: We conducted the study in a total of three analysis sites and 263 subjects. Each site performed an identical CVR MRI procedure using 5% carbon dioxide inhalation. A global cognitive measure of Montreal Cognitive Assessment (MoCA) and an executive function measure of item response theory (IRT) score were used as outcomes.

RESULTS: CVR …

Transcriptomics Analysis Reveals Potential Regulatory Role Of Nsmase2 (Smpd3) In Nervous System Development And Function Of Middle-Aged Mouse Brains, Zhihui Zhu, Timothy S. Mcclintock, Erhard Bieberich

Markey Cancer Center Faculty Publications

Neutral sphingomyelinase-2 (nSMase2), gene name sphingomyelin phosphodiesterase-3 (Smpd3), is a key regulatory enzyme responsible for generating the sphingolipid cer- amide. The function of nSMase2 in the brain is still controversial. To better under- stand the functional roles of nSMase2 in the aging mouse brain, we applied RNA-seq analysis, which identified a total of 1462 differentially abundant mRNAs between +/fro and fro/fro, of which 891 were increased and 571 were decreased in nSMase2-deficient mouse brains. The most strongly enriched GO and KEGG annota- tion terms among transcripts increased in fro/fro mice included synaptogenesis, syn- apse development, synaptic signaling, axon development, and …

Cigarette Smoke-Induced Epithelial-To-Mesenchymal Transition: Insights Into Cellular Mechanisms And Signaling Pathways, Sarah Mohammed Alqithami, Amrita Machwe, David K. Orren

Markey Cancer Center Faculty Publications

This review delves into the molecular complexities underpinning the epithelial-to-mesenchymal transition (EMT) induced by cigarette smoke (CS) in human bronchial epithelial cells (HBECs). The complex interplay of pathways, including those related to WNT//β-catenin, TGF-β/SMAD, hypoxia, oxidative stress, PI3K/Akt, and NF-κB, plays a central role in mediating this transition. While these findings significantly broaden our understanding of CS-induced EMT, the research reviewed herein leans heavily on 2D cell cultures, highlighting a research gap. Furthermore, the review identifies a stark omission of genetic and epigenetic factors in recent studies. Despite these shortcomings, the findings furnish a consolidated foundation not only for the …

Cryo-Em Reconstruction Of Oleate Hydratase Bound To A Phospholipid Membrane Bilayer, Michael L. Oldham, M. Zuhaib Qayyum, Ravi C. Kalathur, Charles O. Rock, Christopher D. Radka

Markey Cancer Center Faculty Publications

Oleate hydratase (OhyA) is a bacterial peripheral membrane protein that catalyzes FAD-dependent water addition to membrane bilayer-embedded unsaturated fatty acids. The opportunistic pathogen Staphylococcus aureus uses OhyA to counteract the innate immune system and support colonization. Many Gram-positive and Gram-negative bacteria in the microbiome also encode OhyA. OhyA is a dimeric flavoenzyme whose carboxy terminus is identified as the membrane binding domain; however, understanding how OhyA binds to cellular membranes is not complete until the membrane-bound structure has been elucidated. All available OhyA structures depict the solution state of the protein outside its functional environment. Here, we employ liposomes to …

Nsd3::Nutm1 Fusion Sarcoma Mimicking Malignant Peripheral Nerve Sheath Tumor With Prolonged Survival, Jing Di, Ali M. Alhaidary, Chi Wang, Jinge Liu, Sainan Wei, Joseph Valentino, Therese J. Bocklage

Markey Cancer Center Faculty Publications

Nuclear Protein in Testis (NUT)-rearranged tumors comprise predominantly NUT car- cinoma but also include certain lymphomas, leukemias, skin appendage tumors, and sarcomas. Although histologically diverse, all are genetically identified by oncogenic rearrangement in the NUTM1 gene. Many fusion partners occur, and NSD3 is NUT carcinoma’s third most common partner. Herein, we present a case of a 26-year-old man with an NSD3::NUTM1 fusion sarcoma. The patient presented at the age of 13 months with a scalp nodule. Over the next 24 years, he experienced five local recurrences and ultimately expired of a rapidly progressive recurrence. His treatment included surgical resections, radiation, …

Influence Of Postruminal Casein Infusion And Exogenous Glucagon-Like Peptide 2 Administration On The Jejunal Mucosal Transcriptome In Cattle, Ronald J. Trotta, Kendall C. Swanson, James L. Klotz, David L. Harmon

Animal and Food Sciences Faculty Publications

We previously demonstrated that postruminal casein infusion and exogenous glucagon-like peptide 2 (GLP-2) administration independently stimulated growth and carbohydrase activity of the pancreas and jejunal mucosa in cattle. The objective of the current study was to profile the jejunal mucosal transcriptome of cattle using next-generation RNA sequencing in response to postruminal casein infusion and exogenous GLP-2. Twenty-four Holstein steers [250 ± 23.1 kg body weight (BW)] received a continuous abomasal infusion of 3.94 g raw corn starch/kg of BW combined with either 0 or 1.30 g casein/kg of BW for 7 d. Steers received subcutaneous injections at 0800 and 2000 …

Effects Of A Proprietary Kelp Blend Product On Enteric Methane Production And Tissue Residues In Cattle, Alexander Altman, Eric Vanzant, Sydney Davis, David Harmon, Kyle R. Mcleod

Animal and Food Sciences Faculty Publications

Three experiments were performed investigating bovine enteric methane (CH₄) production inhibition using a proprietary kelp blend product (PKBP) containing a halogenated methane analog (i.e., bromoform). Calves were fed a corn-silage basal diet top-dressed with the assigned treatment, with rations provided at 1.5 × NE_m in Experiments 1 and 2 (n = 12 and 6 steers, respectively) and ad libitum in Experiment 3 (n = 9 steers). In Experiment 1, we evaluated bromoform’s potency in decreasing CH₄. Dry matter intake (DMI) was not affected by treatment (p ≥ 0.11; 0 vs. 52.5 ± 10.5 ppm bromoform), …

Evaluation Of Manual Thermal Brake Screening Systems, Jeeyen Koo, David Leddy, Jennifer Walton

Kentucky Transportation Center Research Report

In 2021, manual thermal brake screening systems were installed at Lyon EB and Rowan County weigh stations. Two additional units were installed at Laurel SB and Scott County weigh stations the following year. Although this system is called a thermal brake screening system, its thermal camera images are used to find both brake and tire-related violations. At the time of this project, Lyon (EB), Rowan, and Scott County inspection locations also had tire pressure detection systems in addition to manual thermal brake screening systems. Both systems can be used to identify tire-related violations, but inspectors prefer to use the tire …

Adhesion G Protein-Coupled Receptor Latrophilin 1 (Adgrl1): A Novel Regulator Of Glucose And Energy Homeostasis., Kavaljit H Chhabra

Pharmacology and Nutritional Sciences Faculty Publications

No abstract provided.

Economics - The Neglected Dimension Of Pasture Disease R&D, N D. Macleod

IGC Proceedings (1977-2023)

Pasture utilisation underpins a significant contribution of livestock industries to Australia’s economic well-being. Pasture disease represents a direct threat to these enterprises but the economic magnitude of this threat remains largely unknown as the contribution of agricultural economics to pasture disease R&D, management and policy making has been minimal to date. Some insights to explain this apparent neglect are highlighted and a suggestion is made for a multiple disciplinary approach to R&D.

The 'Pendulum Paradigm' - Trends In Nitrogen Fertilizer Use On Temperate Grass/ Clover Pastures, R J. Eckard, F R. Mckenzie, P A. Lane

IGC Proceedings (1977-2023)

Nitrogen fertiliser responses, on perennial ryegrass (Lolium perenne) / white clover (Trifolium repens) dominant pastures, are compared between sub-tropical South Africa and temperate Australia. The data highlight the similarity in inflection point of the response curve, while emphasising the influence of high residual soil N at lower N application rates. The propensity of communities to oscillate between extremes in terms of N fertiliser use on intensive pasture, or the ‘Pendulum Paradigm’ is discussed. Particular reference is made to the dramatic increase in N fertiliser use in dairy pasture of temperate Australia and New Zealand. Emphasis is …

Linking Grassland And Range National Goals With The Grazing Lands Conservation Initiative For National Benefit, David B. Hannaway, Walter F. Wedin, Gerald W. Evers

IGC Proceedings (1977-2023)

Grassland and Range National Goals (GRNGs) were developed to identify national research and education needs for these resources, both public and private. The Grazing Lands Conservation Initiative (GLCI) developed within the NRCS to address the need for technical assistance for the management of privately held grazing lands. These activities are complimentary and, when combined, will address the national need for research, education, and technical assistance leading to better management of grassland and range resources.

The Effect Of Grazing On Etiolated Regrowth In Eight Grass Species, H A. Lardner, S.B M. Wright, R.D H. Cohen

IGC Proceedings (1977-2023)

Grazing by herbivores affects grass species both morphologically and physiologically. A grazing study was conducted on an irrigated pasture near Outlook, Saskatchewan, Canada during the summers of 1991 and 1992 to determine etiolated regrowth after grazing of reed canarygrass (Phalaris arundinacea L.), slender wheatgrass (Elymus trachycaulus (Link) Gould ex Shinners subsp. trachycaulus), intermediate wheatgrass (Thinopyrum intermedium (Host) Barkw. & D.R. Dewey subsp. intermedium), orchardgrass (Dactylis glomerata L.), meadow bromegrass (Bromus beibersteinii Roem. & Schult.), smooth bromegrass (Bromus inermis Leyss.), tall fescue (Festuca arundinacea (Schreb.) Wimm.) and timothy (Phleum pratense L.) in …

A Vison Of The Future World Food Production And Implications For The Environment And Grasslands, Per Pinstrup Andersen, Rajul Pandya Lorch

IGC Proceedings (1977-2023)

Increases in world population, projected to rise to 8 billion by 2020, and the resultant demand for food places great pressure on our agricultural and aquacultural resources. Anxiety about the future is exacerbated by decreasing grain stocks. Production increases of many commodities are projected to be between 1 and 2% per annum and will generally be higher in developing than in developed countries. Cultivatable land area will increase in some areas of the world but not in others. To cope with these challenges, yield increases will be essential and the application of existing knowledge and technologies will not suffice. Accelerated …

Canada's Forage Resources, D Mccartney, P R. Horton

IGC Proceedings (1977-2023)

Canada is the second largest country in the world and stretches 5,500 km east to west and 4,600 km north to south. About 90% of Canada is uninhabited with 90% percent of the population living within 500 km of the Canadian-American border. About 60% of Canadians live in southern Ontario and Quebec. The grazing industry is located primarily in western Canada with British Columbia, Alberta, Saskatchewan and Manitoba having 84% of the national beef herd. Ontario and Quebec have 73% of the national dairy herd. The majority of harvested forage, dehydrated alfalfa and forage seed crops are grown in western …