Digital Commons Network^™

Shaping A City: Municipal Housekeeping, Civic Activism, And Urban Environmentalism In Progressive Era Louisville Through The Women’S City Club, Amy J. Malventano

Theses and Dissertations--History

At the turn of the twentieth century, rapid industrialization and urban expansion transformed American cities, creating urgent challenges in governance, public health, and environmental management. In response, women across the United States extended their domestic expertise into the public sphere, spearheading initiatives to improve sanitation, waste disposal, and urban infrastructure. This dissertation examines the Louisville Women’s City Club (LWCC) as a case study of municipal housekeeping, demonstrating how middle-class women used their traditional roles to influence systemic reform in Louisville, Kentucky. By bridging gender history, urban environmentalism, and Progressive Era activism, this study reveals how the LWCC shaped public policy …

“A True And Broad Sympathy:” Thomas Hughes, Medievalism, And Social Justice In The Nineteenth Century, Sarah E. Stapleton

Theses and Dissertations--History

Thomas Hughes, author of Tom Brown’s Schooldays (1857), used medievalism to help solve social problems of the Nineteenth Century. This contravenes the traditional view of medievalism, especially Anglo-Saxonism, since others have used it to justify the subjugation of people of lower social status, namely the poor in England, enslaved African Americans in the United States, and Indians under British rule.

While the use of medievalism is veiled in Hughes’ work, the subtext of Tom Brown’s Schooldays demonstrated Hughes’ Anglo-Saxonism. Tom Brown and the intertextual material surrounding his narrative exhibit the characteristics of Anglo-Saxonism through cultural primitivism, the concept of allodial, …

The Alchemy Of Jim Crow And Chinese Exclusion: A Study Of Chinese Mississippian Experience From Reconstruction To The Civil Rights Movement, 1870-1967, Sixu Liu

Theses and Dissertations--History

This dissertation examines the history of the Chinese community in Mississippi from the Reconstruction era to the late 1960s. Despite the modest size of their population, the experience of Chinese Mississippians helps us answer a number of key questions regarding two of America’s most impactful institutions, Chinese exclusion and Jim Crow, and their recipients. Why did Chinese Mississippians come to a state that was known for racial hatred and racial oppression? How should a people that was neither Black nor White situate themselves in a society dictated by a Black-White binary? How did Mississippi, a state that was often not …

Regularized Methods For Tensor Recovery And Processing, Katherine J. Henneberger

Theses and Dissertations--Mathematics

The rapid growth of high-dimensional data has exposed the limitations of traditional vector and matrix-based methods for data analysis. These methods often struggle with computational inefficiencies, loss of critical cross-dimensional correlations, and challenges inherent in high-dimensional data. Tensors—multidimensional arrays—offer a robust framework for modeling and analyzing complex data. Tensor methods have proven valuable in tasks such as dimensionality reduction, feature extraction, and data compression, underpinning advancements in machine learning, computer vision, signal processing, and remote sensing.

This thesis focuses on two challenges in tensor analysis: tensor recovery and tensor processing. Tensor recovery addresses the reconstruction of incomplete or corrupted tensors. …

Two Network Flow Problems: Volume Inequalities For Flow Polytopes Of Full Directed Acyclic Graphs; Optimal Additions To The Low-Stress Bike Network In Lexington, Kentucky, James F. Mcelroy

Theses and Dissertations--Mathematics

This dissertation addresses two distinct problems related by their foundation in network flows. The first problem concerns volumes of flow polytopes of directed acyclic graphs with out-degree sequence (3,2,...,2,0). It is proved that there is an interchange operation on the edge set of these graphs that induces a partial order on the graphs isomorphic to a Boolean algebra, and that moving up through this partial order decreases (weakly) the volumes of the corresponding flow polytopes. This result is reinterpreted in the context of linear extensions for posets that are bipartite non-crossing trees.

The second problem develops a discrete optimization model …

Novel Generative And Language Model Architectures With Applications, Edison Mucllari

Theses and Dissertations--Mathematics

This dissertation investigates novel architectures to address fundamental challenges in machine learning, particularly focusing on transformer models, recurrent neural networks, GAN and continual learning and their applications in natural language processing and computer vision. We propose the Neumann-Cayley Gated Recurrent Unit (NC-GRU), which leverages a Neumann series-based Scaled Cayley transformation to maintain orthogonal weight matrices, effectively mitigating exploding gradients problems while improving long-term memory retention across prediction tasks. We demonstrate the practical applications of NC-GRU by implementing our proposed architecture into an autoencoder to derive neural molecular fingerprints. Building upon these advancements, we turn our attention to the transformer architecture, …

Blow-Ups And Projectivized Toric Vector Bundles, Sara Church

Theses and Dissertations--Mathematics

This dissertation is set in the intersection of toric geometry, tropical geometry, and the theory of vector bundles. We focus on the geometry of projectivized toric vector bundles and their connections to Mori dream spaces, matroid theory, and tropical geometry. We generalize previous results on the quotient construction of Gonzalez, Hering, Payne, and Suss (GHPS) by introducing a new approach to describing the geometry of these bundles via associated blow-ups. Additionally, we examine tautological bundles arising from representable matroids and establish connections between their geometry and the wonderful compactification. Finally, we consider the case where Klyachko filtrations have maximal steps …

The Computational Algebra Of Conformal Blocks, Casey B. Hill

Theses and Dissertations--Mathematics

Conformal blocks are objects in quantum field theory that arise from conformal trans- formations, which are symmetries that preserve angles but not length. This aspect of conformal field theory has various interactions with algebraic geometry.

In this dissertation, we explore the underlying algebra and geometry of spaces and algebras of conformal blocks over SLn. We then use this information along with techniques from combinatorial commutative algebra, algebraic geometry, and representation theory to find a presentation of the algebra of SL4-conformal blocks. With this presentation, we then use computational methods to learn about some of the geometric properties of this algebra.

Applied Essays In Industrial Organization: Pricing In Short-Term Rental Markets And Policy Implications In Tobacco Consumption, Richard J. Applin

Theses and Dissertations--Economics

Economics 101 teaches that the interaction between supply and demand determines the prices and quantities consumers face. In econometric research, it is critical to remain aware of this canonical fact, as failure to do so can introduce bias in the estimation of economic parameters. This dissertation empirically demonstrates the importance of factoring in economic structure in three applied essays.

In the first essay, I estimate the impact of rating visibility on Airbnb pricing using a two-way fixed effects model. To do so, I primarily rely on an instrumental variables approach that I argue should identify a supply-side relationship. I provide …

Three Essays On The Impacts Of Pollution, Isaiah Chapman Bryant Sheth

Theses and Dissertations--Economics

My dissertation is broadly focused on using data to quantify the consequences of pol- lution and is organized into three chapters. Chapter one estimates the effect on infant health of drinking water contamination attributable to tropical cyclones. Chapter two examines the heterogeneous effects of a policy aimed at reducing air pollution based on pre-existing air quality conditions. Lastly, chapter three investigates how regula- tions aimed at shaping housing development to minimize climate risk impacted the housing market in Houston Texas. Each of these chapters considers different con- sequences of pollution, from direct health costs of pollution exposure to secondary effects …

Essays On The Labor Market Consequences Of Economic Uncertainty, Emographics, And Oil Price Shocks, Linli Zhao

Theses and Dissertations--Economics

This dissertation explores how economic uncertainty and oil price shocks influence the U.S. labor market, focusing on the roles of age distributions, manufacturing characteristics, and labor skills. Chapter One investigates how uncertainty and age distribution affect employment volatility across U.S. states using data from 2000 Q1 to 2017 Q4. The findings show that states with a larger share of prime-aged workers experience lower employment volatility in the face of economic uncertainty. Chapter Two examines how global oil shocks influence manufacturing job flows, drawing on data from the Annual Survey of Manufactures and the Census of Manufacturers between 1980 Q3 and …

Targeting Prmt5 In Inflammation And Cancer: A Nexus Of Endotoxin Signaling, Antigen Presentation And Immune Evasion., Jimmy James Msemo

Theses and Dissertations--Medical Sciences

Protein Arginine Methyltransferase 5 (PRMT5) is a member of PRMT family that controls both intrinsic and extrinsic oncogenic processes [1]. Protein arginine methyltransferase 5 (PRMT5) is a type II methyltransferase that exerts widespread influence over gene expression, splicing, DNA repair, and immune regulation through symmetric dimethylation of arginine residues on histone and non-histone proteins [2]. The addition of methyl groups induces gene silencing through producing dictatorial histone marks like H2AR3ne2s, H3R8me2s and H4R3mes [3], which act as epigenetic repressive marks on gene promoters. In non-histone proteins, PRMT5 can methylate and regulate transcription factor proteins such as p53, E2F1, and p65, …

Investigating Regulation And The Regulome Of The Nucleic Acid Binding Protein Spovg Within Borrelia Burgdorferi, Timothy C. Saylor

Theses and Dissertations--Medical Sciences

Prior studies indicated Borrelia burgdorferi SpoVG protein was regulated, SpoVG binds specifically to a number of nucleic acids, and SpoVG binds to the non-variable section of the major virulence factor vlsE. Although a direct transcriptional activator or inhibitor was not elucidated, it is shown that SpoVG is regulated based on cell culture density independent of the growth rate of B. burgdorferi, indicating that SpoVG regulation is outside the scope of the alternative sigma factor RpoS. Using a dCas9 CRISPRi construct to target SpoVG resulted in protein expression trending towards upregulation of the BosR-RpoS regulon, and a marked decrease …

Cellular And Behavioral Consequences Of Psychedelic Drug Action In The Claustrum, Tanner L. Anderson

Theses and Dissertations--Neuroscience

Psychedelics are rapidly garnering research attention for their ability to successfully treat a variety of psychiatric diseases after one or a handful of treatments in recent clinical research. Among the conditions treated is substance use disorder (SUD), which afflicted 48.5 million (16.7%) Americans aged 12 and older in 2023 (NSDUH). As clinical trial results continue to show lasting positive effects of psychedelic psychotherapy, there remains an enormous gap in knowledge regarding how these drugs cause lasting changes in the brain to achieve these therapeutic effects. It has been suggested that psychedelics must induce rapid and long-lasting neuronal plasticity in order …

Leveraging Clinical Standards To Improve The Translational Relevance Of Therapies For Experimental Spinal Cord Injury, Aaron L. Silverstein

Theses and Dissertations--Neuroscience

Efforts to improve treatment of spinal cord injury (SCI) often use animals to develop effective therapeutics, intending to improve the survival and the quality of life of persons with SCI. Over half of all SCIs in the United States occur at the cervical level and often cause locomotor deficits and life-threatening breathing dysfunction. Thus, my dissertation is focused on this important patient population.

After beginning with a description of translational research and surveying SCI from a clinical standpoint, I turned to describe experimental models of cervical SCI and more detailed neuroimmunological findings relevant to my work. Then, I conducted a …

Immune Dynamics And B Cell Contributions To Neuroplasticity And Recovery After Stroke, Thomas A. Ujas

Theses and Dissertations--Neuroscience

This dissertation explores the dynamic interplay between the immune system and the brain across stroke and aging using clinical, post-mortem, and pre-clinical models. The immune system plays critical roles in shaping brain function, responding to injury, and mediating recovery. These studies aim to enhance our understanding of neuroimmune dynamics across spatial and temporal dimensions.

In the first part, we conducted longitudinal sampling of aneurysmal subarachnoid hemorrhage (aSAH) patients to track immune cell and cytokine changes at days 3, 5, 7, 10, and 14 post-stroke, with a focus on delayed cerebral ischemia (DCI), a common complication. We observed distinct temporal patterns, …

Understanding The Impact Of The Medicaid Expansion On Hospital Length Of Stay And Emergency Department Use In Kentucky, Cameron Bushling

Theses and Dissertations--Epidemiology and Biostatistics

Three related analyses were performed to try to understand the immediate effects of Medicaid expansion on hospital systems in Kentucky. Medicaid expansion led to a large, sudden increase in the number of individuals eligible for various health care needs. This sudden increase in demand for health services lead to initial hypotheses regarding hospitals’ ability to handle this demand. The first analysis examined hospital average length of stay (LOS) using a linear mixed-effects model. Length of stay was modeled longitudinally between 2013 and 2015 to determine if significant changes in the slope of LOS could be detected after expansion (2014). Separate …

Changes In Cancer Diagnosis And Survival In The United States During The Covid-19 Pandemic, Justin T. Burus

Theses and Dissertations--Epidemiology and Biostatistics

The COVID-19 Pandemic led to global societal disruptions as political leaders and public health authorities attempted to control the spread of the newly discovered SARS- CoV-2 virus. While these measures were designed to lessen morbidity and mortality from a novel pathogen, their impact was also felt in many other, often unintended ways. The purpose of this dissertation is to use cancer surveillance research methods to examine the association between COVID-19 Pandemic-related disruptions and changes in the normal diagnosis and care of cancer in the United States.

The first two studies of this dissertation analyzed reductions in cancer diagnoses in the …

Ideals And Idealization: Responding To Rawls And His Critics, Clayton J. Houdeshell

Theses and Dissertations--Philosophy

In A Theory of Justice, John Rawls argues that any participant taking on the role as impartial spectator in his original position thought experiment would select “justice as fairness” as the most reasonable theory of justice to reorganize a basic structure’s system of institutions and public rules. In this dissertation it is my aim to outline seven criticisms of the Rawlsian account related to his method of ideal theory, the rationality and values of the impartial spectator, the instilment of a particular conception of the good and an aversion to non-liberal theories, and argue that each of them fail to …

Hannah Arendt As Hermeneutic Phenomenologist: Natality And The Miracle Of Philosophy, Andrew H. Marquis

Theses and Dissertations--Philosophy

I argue that Hannah Arendt practiced hermeneutic phenomenology in the canonical mode of her mentor, Martin Heidegger. Hermeneutic phenomenology is not a philosophical school defined by methods, results, or topics. It is a practice of transformative thinking by which we work through the burdens of who and how we have been towards the possibilities of who and how we could be. Heidegger, burdened by the scientism of his philosophical milieu, articulated this practice not by rejecting scientistic philosophies outright but by interpretively recovering their most promising tendencies.

Though seldom recognized as a hermeneutic phenomenologist, Arendt’s philosophical response to Nazism reveals …

Internalism, Externalism, And The Phenomenology Of Epistemic Justification, Steven Winterfeldt

Theses and Dissertations--Philosophy

This dissertation applies a phenomenological method of analysis to the dispute between analytic internalists and externalists regarding epistemic justification. Traditionally, the justification condition on knowledge has been interpreted as an internal condition, but the growing popularity of the externalist antithesis has placed internalism on the defensive. Ultimately, however, the dispute appears to have fallen into an impasse. I identify a set of four arguments or cases that, when taken together, prompt us to adopt a set of contradictory conclusions about the necessary and sufficient conditions for justified belief. Moreover, none of the analytic views of justification surveyed seem to be …

Harnessing Ethnicity For Effective Leadership: Reimagining Ethnic Politics As An Institutional Asset In Africa, Obaloluwa A. Aka

Theses and Dissertations--Political Science

Ethnic identity remains one of the most enduring forces shaping political behavior and leadership in Africa. Often viewed as a source of division, this study reframes ethnicity as an institutional asset capable of fostering accountability and enhancing leadership quality. Drawing on Afrobarometer Round 9 data from 35 African countries, the paper shows that ethnicity consistently predicts vote choice affirming its political salience. Rather than treating this as a democratic obstacle, the analysis demonstrates that when mediated through trusted traditional leaders, ethnic identity can strengthen satisfaction with democracy, trust in institutions, and perceptions of governance. Logistic regression models reveal that trust …

Towards A Sociological Theory Of Consent And Coercion In Sexual Violence Against Women, Lisa Kistler

Theses and Dissertations--Sociology

Recent data estimate that 26.8% of adult women in the U.S. have experienced rape in their lifetime. In this context, the phrase “consent to sex” is a prominent narrative countering sexual violence. Yet, there is no consensus on the meaning of consent, nor how the practice of consent is affected by coercion, resulting in a puzzle of consent. In response, the present project brings together existing research and theory to conceptualize consent and coercion in new ways. It asks, broadly, how do different forms of coercion complicate sexual consent and contribute to sexual violence against women today and answers this …

A Comprehensive Exploration Of Stress And Depressive Symptoms In Farm Populations, Julie C. Derringer

Theses and Dissertations--Nursing

High rates of depression and suicide continue to be a concern, despite four decades of growing research into the mental health of farmers. Most farmers have an awareness of a need for improved mental health, but a lack of knowledge persists. As agricultural production demands increase and the number of family farms decreases, the stress placed upon farmers to support the food chain is higher than ever. Understanding the association between farm demands and resources among farmers is key for the development and implementation of programs to decrease occupational stress and depressive symptoms to improve mental health outcomes across farming …

Using Hyperactive Shp-2 Mutants, A Phosphatase, To Identify Interactions With The Rna Helicase Ddx3, Devin Montgomery

Theses and Dissertations--Pharmacy

Protein-protein interactions are critical in cellular signaling pathways. This project investigates binding interactions between SHP-2, a tyrosine phosphatase, and DDX3, an RNA helicase. There is a specific focus on the impact that gain-of-function SHP-2 mutations may impact binding to DDX3 via conformational change. Using immunoprecipitation protocols as well as western blotting we were able to provide insights into SHP-2 molecular mechanisms and subsequent binding to DDX3.

Anxiolytic Intervention: Modulation Of Cell Types Due To Nicotine Withdrawal, Taylor Elder

Theses and Dissertations--Pharmacy

Nicotine use disorder (NUD) remains a leading cause of preventable disease, yet the neurobiological mechanisms underlying nicotine withdrawal are incompletely understood. Emerging evidence implicates neuroimmune signaling and astrocytic regulation of glutamate in shaping the withdrawal-associated affective phenotype. This dissertation investigated these processes using multiple nicotine administration paradigms including osmotic minipump implant, cigarette smoke exposure, and nicotine vapor inhalation to model diverse routes of human nicotine intake.

Chapter 2 examines the effects of these three modes of administration on neuroinflammation and validation of nicotine delivery. Nicotine exposure was confirmed through receptor [³H]Epibatidine nAChR binding assay and serum cotinine measurements. …

Investigating The Role Of Dynamic Signaling Of Nrg3-Erbb4 In The Prefrontal Cortex In Mediating Nicotine Withdrawal Phenotypes, Emily Prantzalos

Theses and Dissertations--Pharmacy

While several pharmacotherapies are currently available for nicotine use disorder (NUD), smoking cessation success rates remain below 10% each year. The molecular mechanisms underlying failed quit attempts continue to represent a critical gap in our knowledge. However, recent advances in understanding the genetic contributions to nicotine dependence offer a promising avenue for developing more effective cessation therapies. Prior research has identified genetic variation in Neuregulin 3 (Nrg3) and its cognate receptor ErbB4 as potential contributors to affective nicotine withdrawal (WD) phenotypes and cessation outcomes. Therefore, this dissertation aims to systematically investigate the region-specific, functional role of the Neuregulin Signaling Pathway …

Leveraging Transcriptomics And Behavior To Investigate Potential Neuronal And Glial Drivers Of Substance Use Disorder Endophenotypes, Jack V. Keady

Theses and Dissertations--Pharmacy

Over 54 million Americans needed substance use treatment in 2023. While there are many facets of substance use disorder, two major issues of interest are the negative reinforcing aspects of substances of abuse, manifesting in part as withdrawal symptomologies, and why a subset of people who use substances of abuse escalate to a use disorder. Nicotine exposure models were used to investigate the mechanisms of withdrawal endophenotypes, as smoking is the leading cause of preventable death in the United States, and a fentanyl self-administration model was used to probe individual differences in escalation phenotypes, as 80% of overdose deaths in …

The Impact Of Maternal Environmental Exposures On The Immune Landscape Of The Maternal-Fetal Interface, Heather E. True

Theses and Dissertations--Pharmacy

Maternal environmental exposures and inflammation are known to impact fetal development in utero as well as increase the risk for chronic diseases later in life. Therefore, it is essential that we understand how the maternal environment alters placental structure and immune function.

Therefore, we isolated fetal (chorionic villous) tissues from the placentas of healthy pregnant participants (control) and those with inflammatory conditions, including SARS-COV-2 infection, pregravid obesity, and opioid use disorder. Isolated placental leukocytes were subjected to a series of assays to uncover the phenotypic, functional, and transcriptional (single-cell RNA-sequencing) landscape of placental immune cells. Additional placental tissues were subjected …

Collision Avoidance Information System Utilizing Machine Learning Image Recognition, Michael W. Long

Theses and Dissertations--Mining Engineering

This thesis addresses significant safety challenges presented by powered haulage fatalities in underground mining by developing and evaluating a machine learning-driven Collision Avoidance Information System (CAIS). The research utilized a ZED 2i camera to capture both RGB and depth data for enhanced spatial awareness in visually limited underground environments. A specialized dataset of underground mining equipment was captured from limestone and zinc mines, annotated, and used to train a segmentation network. The CAIS was field-tested in diverse underground settings, achieving an accuracy of 82% in a limestone mine similar to the training data, but a lower accuracy of 45% in …