Digital Commons Network^™

Pathways To Discover: Exploring Transdisciplinary Learning With Primary Sources, Matthew Strandmark

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Varied Uses Of Class Time: A Case Study Of Epe 301, Zitsi Mirakhur, Spencer Crawford, Wyatt Driskell

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

What In The World Can I Do With This Degree? Showcase Profile Assignment, Sarah Kercsmar

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Groupme In The Classroom, Christopher Huggins

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Social Media And The Study Of Feminisms, Frances Henderson

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Meeting Community Need In The Classroom: Creative Collaborations Between Students And Cooperative Extension, Liz Combs, Heather Norman-Burgdolf

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Zines: Radical Tools For Empathy And Introspection, Aanya Chugh

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Conversations By Design: Student Research Using Oral Histories, Jennifer Bartlett, Patrick Lee Lucas

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Introduction To Section One - Featured Essays From Presenters At The Uk Teaching Excellence Symposium, Trey Conatser

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Front Matter

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Deformation And Collectivity In Doubly Magic Pb 208, J. Henderson, J. Heery, M. Rocchini, M. Siciliano, N. Sensharma, A. D. Ayangeakaa, R. V.F. Janssens, T. M. Kowalewski, Abhishek, P. D. Stevenson, E. Yüksel, B. A. Brown, T. R. Rodriguez, L. M. Robledo, C. Y. Wu, S. Kisyov, C. Müller-Gatermann, V. Bildstein, L. Canete, C. M. Campbell, S. Carmichael, M. P. Carpenter, W. N. Catford, P. Copp, C. Cousins, M. Devlin, D. T. Doherty, P. E. Garrett

Chemistry Faculty Publications

Lead-208 is the heaviest known doubly magic nucleus and its structure is therefore of special interest. Despite this magicity, which acts to provide a strong restorative force toward sphericity, it is known to exhibit both strong octupole correlations and some of the strongest quadrupole collectivity observed in doubly magic systems. In this Letter, we employ state-of-the-art experimental equipment to conclusively demonstrate, through four Coulomb-excitation measurements, the presence of a large, negative, spectroscopic quadrupole moment for both the vibrational octupole 31- and quadrupole 21+ state, indicative of a preference for prolate deformation of the states. The observed quadrupole moment is discussed …

The Core Circadian Clock Factor, Bmal1, Transduces Sex-Specific Differences In Both Rhythmic And Nonrhythmic Gene Expression In The Mouse Heart, Xiping Zhang, Spencer B. Procopio, Haocheng Ding, Maya G. Semel, Elizabeth A. Schroder, Mark R. Viggars, Tanya S. Seward, Ping Du, Kevin Wu, Sidney R. Johnson, Abhilash Prabhat, David J. Schneider, Isabel G. Stumpf, Ezekiel R. Rozmus, Zhiguang Huo, Brian P. Delisle, Karyn A. Esser

Physiology Faculty Publications

No abstract provided.

Dysregulated Alveolar Epithelial Cell Progenitor Function And Identity In Hermansky-Pudlak Syndrome, Joanna Y. Wang, Sylvia N. Michki, Sneha Sitaraman, Brandon J. Banaschewski, Reshma Jamal, Jason J. Gokey, Susan M. Lin, Jeremy B. Katzen, Maria C. Basil, Edward Cantu, Jonathan A. Kropski, Jarod A. Zepp, David B. Frank, Lisa R. Young

Surgery Faculty Publications

Hermansky-Pudlak syndrome (HPS) is a genetic disorder of endosomal protein trafficking associated with pulmonary fibrosis in specific subtypes, including HPS-1 and HPS-2. Single-mutant HPS1 and HPS2 mice display increased fibrotic sensitivity while double-mutant HPS1/2 mice exhibit spontaneous fibrosis with aging, which has been attributed to HPS mutations in alveolar epithelial type II (AT2) cells. We utilized HPS mouse models and human lung tissue to investigate mechanisms of AT2 cell dysfunction driving fibrotic remodeling in HPS. Starting at 8 weeks of age, HPS mice exhibited progressive loss of AT2 cell numbers. HPS AT2 cell function was impaired ex vivo and in …

Evaluating Maternal Drug Use Disparities, Risk Factors And Outcomes In Northeast Arkansas: A Pre, During, And Post-Covid-19 Pandemic Analysis., Enrique Gomez Pomar, Johnna Berryhill, Sudeepa Bhattacharyya

Pediatrics Faculty Publications

INTRODUCTION: The use of addictive substances remains a major health problem in the U.S. An increase in drug overdose and mortality was observed during the COVID-19 pandemic, especially in underserved populations. This surge also impacted pregnant women especially with the use of marijuana (THC) and opioids.

METHODS: Retrospective study analyzing mother-infant dyads with reported Meconium Drug Screen (MDS) results, from January 2018 through April 2023 at a reference hospital serving an urban and rural area of Arkansas. Due to the absence of universal screening, the prevalence of drug use was variable during the study period. An adjusted monthly positive rate …

Evaluating Maternal Drug Use Disparities, Risk Factors And Outcomes In Northeast Arkansas: A Pre, During, And Post-Covid-19 Pandemic Analysis., Enrique Gomez Pomar, Johnna Berryhill, Sudeepa Bhattacharyya

Pediatrics Faculty Publications

INTRODUCTION: The use of addictive substances remains a major health problem in the U.S. An increase in drug overdose and mortality was observed during the COVID-19 pandemic, especially in underserved populations. This surge also impacted pregnant women especially with the use of marijuana (THC) and opioids.

METHODS: Retrospective study analyzing mother-infant dyads with reported Meconium Drug Screen (MDS) results, from January 2018 through April 2023 at a reference hospital serving an urban and rural area of Arkansas. Due to the absence of universal screening, the prevalence of drug use was variable during the study period. An adjusted monthly positive rate …

Evaluating Maternal Drug Use Disparities, Risk Factors And Outcomes In Northeast Arkansas: A Pre, During, And Post-Covid-19 Pandemic Analysis., Enrique Gomez Pomar, Johnna Berryhill, Sudeepa Bhattacharyya

Pediatrics Faculty Publications

INTRODUCTION: The use of addictive substances remains a major health problem in the U.S. An increase in drug overdose and mortality was observed during the COVID-19 pandemic, especially in underserved populations. This surge also impacted pregnant women especially with the use of marijuana (THC) and opioids.

METHODS: Retrospective study analyzing mother-infant dyads with reported Meconium Drug Screen (MDS) results, from January 2018 through April 2023 at a reference hospital serving an urban and rural area of Arkansas. Due to the absence of universal screening, the prevalence of drug use was variable during the study period. An adjusted monthly positive rate …

Genomic And Phenotypic Correlates Of Mosaic Loss Of Chromosome Y In Blood, Yasminka A. Jakubek, Xiaolong Ma, Adrienne M. Stilp, Fulong Yu, Jason Bacon, Justin W. Wong, Francois Aguet, Kristin Ardlie, Donna K. Arnett, Kathleen Barnes, Joshua C. Bis, Tom Blackwell, Lewis C. Becker, Eric Boerwinkle, Russell P. Bowler, Matthew J. Budoff, April P. Carson, Jiawen Chen, Michael H. Cho, Josef Coresh, Nancy J. Cox, Paul S. De Vries, Dawn L. Demeo, David W. Fardo, Myriam Fornage, Xiuqing Guo

Biostatistics Faculty Publications

Mosaic loss of Y (mLOY) is the most common somatic chromosomal alteration detected in human blood. The presence of mLOY is associated with altered blood cell counts and increased risk of Alzheimer disease, solid tumors, and other age-related diseases. We sought to gain a better understanding of genetic drivers and associated phenotypes of mLOY through analyses of whole-genome sequencing (WGS) of a large set of genetically diverse males from the Trans-Omics for Precision Medicine (TOPMed) program. We show that haplotype-based calling methods can be used with WGS data to successfully identify mLOY events. This approach enabled us to identify differences …

Amyloid-Β Predominant Alzheimer’S Disease Neuropathologic Change, Gabor G. Kovacs, Yuriko Katsumata, Xian Wu, Khine Zin Aung, David Fardo, Shelley L. Forrest, Peter T. Nelson

Neurology Faculty Publications

Different subsets of Alzheimer’s disease neuropathologic change (ADNC), including the intriguing set of individuals with severe/widespread amyloid-β (Aβ) plaques but no/mild tau tangles [Aβ-predominant (AP)-ADNC], may have distinct genetic and clinical features. Analysing National Alzheimer’s Coordinating Center data, we stratified 1187 participants into AP-ADNC (n = 95), low Braak primary age-related tauopathy (PART; n = 185), typical-ADNC (n = 832) and high-Braak PART (n = 75). AP-ADNC differed in some clinical features and genetic polymorphisms in the APOE, SNX1, WNT3/MAPT and IGH genes. We conclude that AP-ADNC differs from classical ADNC with implications for in vivo studies.

Synergistic Effects Of Plasma S100b And Mri Measures Of Cerebrovascular Disease On Cognition In Older Adults, Colleen A. Pappas, Christopher E. Bauer, Valentinos Zachariou, Timothy Justin Libecap, Beatriz Rodolpho, Tiffany L. Sudduth, Peter T. Nelson, Gregory Jicha, Anika M. S. Hartz, Xingfeng Shao, Danny J. J. Wang, Brian T. Gold

Neurology Faculty Publications

There is growing interest in studying vascular contributions to cognitive impairment and dementia (VCID) and developing biomarkers to identify at-risk individuals. A combination of biofluid and neuroimaging markers may better profile early stage VCID than individual measures. Here, we tested this possibility focusing on plasma levels of S100 calcium-binding protein B (S100B), which has been linked with blood– brain-barrier (BBB) integrity, and neuroimaging measures assessing BBB function (water exchange rate across the BBB (kw)) and cerebral small vessel disease (white matter hyperintensities (WMHs)). A total of 74 older adults without dementia had plasma samples collected and underwent cognitive assessment. A …

Males Differ More Between Developmental Stages Than Females, And Plasticity To Light Is Stage-Dependent In The Tropical Plant Marchantia Inflexa, Jonathan D. Moore, D. Nicholas Mcletchie

Biology Faculty Publications

Plants have evolved strategies to maintain photosynthesis and mitigate tissue-damaging high light. In some dioecious seed plants, these strategies are sexually dimorphic and are linked to spatial segregation of the sexes (SSS) along light gradients. In vascular tissue-free plants (bryophytes) with separate sexes, SSS is common, but how light gradients, sexual dimorphisms, and SSS correlate is not well understood. To test if sexual dimorphisms in vegetative or sexual stages lead to light-associated SSS in bryophytes, we used Marchantia inflexa whose males occupy a wider range of light conditions, including higher light conditions, than females. We also tested if changes in …

Ear Pinna Growth And Differentiation Is Conserved In Murids And Requires Bmp Signaling For Chondrocyte Proliferation, Robyn S. Allen, Shishir K. Biswas, Ashley W. Seifert

Biology Faculty Publications

Despite being a major target of reconstructive surgery, development of the ear pinna remains poorly studied. Here, we provide a cellular characterization of late gestational and postnatal ear pinna development in two rodents and investigate the role of BMP5 in expansion and differentiation of auricular elastic cartilage. We find that ear pinna development is largely conserved between Mus musculus and the highly regenerative Acomys dimidiatus. The pattern of pre-cartilaginous cells is established early in development. These cells are specified into chondroblasts before ear unfolding and then undergo extensive proliferation before maturation. The elastic cartilage, connective tissue fibroblasts, dermal papilla and …

Current Practices In Rock Scaling, Daryl J. Greer, Kean H. Ashurst Jr

Kentucky Transportation Center Research Report

Rockfalls, which result from the chemical and physical weathering of aging exposed rock cuts, occur frequently along many Kentucky roadways and can endanger travelers. Mitigating rockfalls often requires substantial excavation, procuring additional right of way, and/or hiring specialty contractors. An alternative to these expensive processes is rock scaling, which can be a cost-effective tool for mitigating rockfalls. Rock scaling entails removing loose and unstable rocks from rock cut slopes within the right of way to reduce rockfall risk and is being used with increased frequency by state transportation agencies around the country. The Kentucky Transportation Cabinet (KYTC) has completed several …

Bridge Load Posting Based On Load Testing, Cody Hutchinson, Abheetha Peiris, Issam Harik

Kentucky Transportation Center Research Report

AASHTO’s Manual for Bridge Evaluation (MBE) provides guidance for analytically evaluating bridge capacity based on available design information and the results of field inspections. This analysis results in a rating factor (RF), which quantifies a bridge’s safe load carrying capacity. RF accuracy, however, depends on the availability of information about structural details and material properties. As such, load rating bridges without design plans is difficult as field inspections alone often cannot provide enough information to perform detailed analysis. In many instances this means that a bridge would possess a substandard rating factor (RF < 1.0) simply due to the conservative assumptions required to perform traditional analysis. The most effective method for safely modifying such conservative theoretical rating factors is through load testing. Load testing measures actual bridge behavior and, for most bridges in good health, finds an increase in load rating is justified. This project utilized load testing to load rate 14 bridges in Kentucky that lack structural plans. Researchers first determined theoretical ratings using MBE-prescribed methods. For information typically taken from design plans, but which could not be measured directly, data-backed methods for making conservative assumptions were developed. For most bridges included in the study, theoretical rating factors alone suggested load postings were necessary. Load testing was then carried out utilizing tandem rear-axle dump trucks with measured axle weights. Multiple single-lane load cases were selected to maximize the effects being rated. Strain data were collected in real time using a wireless reusable strain gage system. Using these data, researchers computed a field test adjustment factor using MBE methods which directly modified the calculated theoretical RFs. Ultimately, load testing provided sufficient evidence to safely recommend that load postings were not necessary for any bridges in this study.

Amidst The Frenzy Over Deepseek Ai, Us Federal Science And Tech Policy Is A Mess Of Internal Contradictions, Yujia He

Patterson School of Diplomacy and International Commerce Faculty Publications

The release of the R1 model by the Chinese artificial intelligence (AI) company, DeepSeek, shocked the US tech industry. Yujia He writes that while DeepSeek’s model may not be quite as superior compared to its competitors as originally thought, the Trump administration has responded to its innovations by further pushing for US leadership in AI. Taking a close look at US research and development policy under the second Trump administration, however, shows the significant disconnect between rhetoric and policy. Federal funding freezes and reduced funding for the National Science Foundation could have dire long-term consequences for research and international cooperation …

Extracellular Vesicles Released By All Patients Contain Hne-Adducted Proteins: Implications Of Collateral Damage., Jenni Ho, Suriyan Sukati, Tamara Taylor, Sherry Carter, Brittany Fuller, Amy Marmo, Caryn Sorge, John D'Orazio, D Allan Butterfield, Subbarao Bondada, Heidi Weiss, Daret K St Clair, Luksana Chaiswing

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Off-target neuronal injury is a serious side-effect observed in cancer survivors. It has previously been shown that pediatric acute lymphoblastic leukemia (ALL) survivors have a decline in neurocognition compared to healthy age-matched counterparts. Elevated oxidative stress has been documented to be a mediator in off-target tissue damage in cancer survivors. Early detection of oxidative stress markers may provide an opportunity to prevent off-target tissue damage. Extracellular vesicles (EVs) have surfaced as a potential diagnostic tool due to molecular cargo they contain. We investigated the potential for EVs to be a sensitive indicator of oxidative stress and off-target tissue damage by …

Long-Term Agricultural Management Reduces Abundance And Alters Community Structure Of Ground Beetles (Coleoptera: Carabidae), Cynthia M. Fiser, Nathan L. Haan, Douglas A. Landis

Entomology Faculty Publications

Carabid beetles (Coleoptera: Carabidae) are beneficial predators and bioindicators of ground-dwelling arthropod diversity in agricultural landscapes. We studied changes in community composition, activity density, and diversity of carabids in a long-term agroecosystem study spanning 30 years in the US Midwest. We contrasted carabid community metrics measured by pitfall trap sampling in two conservation-oriented treatments in a corn-soybean-wheat rotation. One treatment uses conventional practices but with reduced agrochemical inputs (Reduced Input), while the other has no synthetic inputs (Biologically Based). Since a 1994–95 study on the same site, in 2019 overall carabid activity density had declined a minimum of 58–76 % …

Gestational Weight Gain And Increased Risk Of Cesarean Delivery Across Body Mass Index Categories., Pearl A Mcelfish, Britni L Ayers, Nicola L Hawley, Aaron Caldwell, Austin Porter, Michael D Macechko, Donya Watson, Jennifer A Callaghan-Koru, James P Selig, Jennifer A Andersen, Nirvana Manning, Lanita White, Enrique Gomez-Pomar, Clare C Brown

Pediatrics Faculty Publications

BACKGROUND: Unnecessary cesarean delivery can have negative implications for both mothers and infants. In the United States, the proportion of women undergoing cesarean delivery exceeds the acceptable World Health Organization proportion. Reducing cesarean deliveries is a national goal of Centers for Disease Control and Prevention Healthy People 2030, the American College of Obstetricians and Gynecologists, and the Alliance for Innovation on Maternal Health.

OBJECTIVE: This study aimed to examine if excessive gestational weight gain is associated with increased risk of cesarean delivery across multiple body mass index categories.

STUDY DESIGN: Analysis was conducted using vital records data from the National …

Gestational Weight Gain And Increased Risk Of Cesarean Delivery Across Body Mass Index Categories., Pearl A Mcelfish, Britni L Ayers, Nicola L Hawley, Aaron Caldwell, Austin Porter, Michael D Macechko, Donya Watson, Jennifer A Callaghan-Koru, James P Selig, Jennifer A Andersen, Nirvana Manning, Lanita White, Enrique Gomez-Pomar, Clare C Brown

Pediatrics Faculty Publications

BACKGROUND: Unnecessary cesarean delivery can have negative implications for both mothers and infants. In the United States, the proportion of women undergoing cesarean delivery exceeds the acceptable World Health Organization proportion. Reducing cesarean deliveries is a national goal of Centers for Disease Control and Prevention Healthy People 2030, the American College of Obstetricians and Gynecologists, and the Alliance for Innovation on Maternal Health.

OBJECTIVE: This study aimed to examine if excessive gestational weight gain is associated with increased risk of cesarean delivery across multiple body mass index categories.

STUDY DESIGN: Analysis was conducted using vital records data from the National …

Stress Relaxation Rates Of Myocardium From Failing And Non-Failing Hearts, Marissa Gionet-Gonzales, Gianna Gathman, Jonah Rosas, Kyle Y. Kunisaki, Dominique Gabriele P. Inocencio, Niki Hakami, Gregory N. Milburn, Angela A. Pitenis, Kenneth S. Campbell, Beth L. Pruitt, Ryan S. Stowers

Physiology Faculty Publications

The heart is a dynamic pump whose function is influenced by its mechanical properties. The viscoelastic properties of the heart, i.e., its ability to exhibit both elastic and viscous characteristics upon deformation, influence cardiac function. Viscoelastic properties change during heart failure (HF), but direct measurements of failing and non-failing myocardial tissue stress relaxation under constant displacement are lacking. Further, how consequences of tissue remodeling, such as fibrosis and fat accumulation, alter the stress relaxation remains unknown. To address this gap, we conducted stress relaxation tests on porcine myocardial tissue to establish baseline properties of cardiac tissue. We found porcine myocardial …

Unfolded Von Willebrand Factor Binds Protein S And Reduces Anticoagulant Activity, Martha M.S. Sim, Molly Y. Mollica, Hammodah R. Alfar, Melissa Hollifield, Dominic W. Chung, Xiaoyun Fu, Siva Gandhapudi, Daniëlle M. Coenen, Kanakanagavalli Shravani Prakhya, Dlovan F. D Mahmood, Meenakshi Banerjee, Chi Peng, Xian Li, Alice C. Thornton, James Z. Porterfield, Jamie L. Sturgill, Gail A. Sievert, Marietta Barton-Baxter, Ze Zheng, Kenneth S. Campbell, Jerold G. Woodward, José A. López, Sidney W. Whiteheart, Beth A. Garvy, Jeremy P. Wood

Physiology Faculty Publications

The critical plasma anticoagulant protein S (PS) circulates in 2 functionally distinct pools: free (anticoagulant) or bound to complement component 4b-binding protein (C4BP; anti-inflammatory). Acquired free PS deficiency is detected in several viral infections, but its cause is unclear. Here, we used biochemical approaches and human patient plasma samples to identify an interaction between PS and von Willebrand factor (VWF), which causes free PS deficiency and reduced PS anticoagulant activity. We first identified a shear-dependent interaction between PS and VWF by mass spectrometry. Consistently, PS and VWF could be crosslinked together in plasma, and plasma PS and VWF comigrated in …