Digital Commons Network^™

Development Of A National Alfalfa Quality Assessment Procedure In The United States, V L. Marble, W C. Templeton

IGC Proceedings (1977-2023)

Only a small fraction of the U.S. hay crop is evaluated for nutritive properties. Various states have developed alfalfa hay quality prediction systems based on chemical analysis. Confusion among users has resulted from nonuniformity among systems. Additional factors causing concern include: increased awareness among producers of higher income from the sale of high quality hay; increased demand among dairymen for a prediction system compatible with ration formulation; recognition of the inadequacy and nonuse of U.S. federal hay grades; increased movement of alfalfa hay across state borders; and lack of agreement on duplicate samples sent to different laboratories. After formation of …

The Cultivation And Feeding Value Of Persian Clover, P C. Flinn, K.F M. Reed, G R. Saul, G N. Ward, J G. Graham

IGC Proceedings (1977-2023)

Research with Persian clover (Trifolium resupinatum, ssp. majus) cv. Mara!, in south eastern Australia shows it to be productive and well adapted to waterlogged soils. It is particularly productive in spring when compared with other clovers. Winter production can be increased by sowing Persian clover with Westerwolds ryegrass or oats but the yield of clover in the spring is therby reduced. Persian clover conserved as hay was found to have a low neutral detergent fibre content (28.1 % ). In a 60 day feeding trial, lambs were fed Persian clover hay (78.5% digestible dry matter), lucerne hay (63.0% …

Voluntary Intake And Digestibility Of Two Selected Tropical Grasses By Swamp Buffaloes, M Wanapat, A Topark-Ngarm

IGC Proceedings (1977-2023)

A study on chemical compositions, voluntary feed intake and nutrient digestibility of Panicum maximum cv. Guinea and Brachiaria decumbens cv. Signal at three regrowth cuttings (week 4, 8, 12) by swamp buffalo steers, was conducted. Dry matter, acid detergent lignin contents increased whereby ash, crude protein and neutral detergent fiber contents decreased, as the plants matured. Acid detergent fiber fraction remained similar for all cuttings. Voluntary dry matter intake and digestion coefficients of nutrients were relatively high at week 4 and 8 and markedly low at week 12 for both species. Buffaloes fed with signal grass had higher intakes and …

Research For Selection Criteria For Grass Quality, Based Upon Animal References, M Gillet, J Scehovic, M Lila

IGC Proceedings (1977-2023)

In an effort to find selection criteria for intake and digestibility, based on correlations with the same characters measured on animals, we have compared 4 to 6 grasses of similar heading dates for intake, palatability, digestibility by sheep, intake by goats and many laboratory tests. 1979 results were published for Lexington Congress. Results of 1980 and 1981 springs bear them out in several points :

- palatability was a very precise and stable test

- palatability, digestibility and goat intake were stable and correlated with each other

- soluble phenols were able to predict palatability and part of digestibility

-sheep …

Using Grinding Energy Measurements For Predicting Crude Fibre Content In First Growths Of Permanent Grassland, Chr Paul, U V. Borstel, E Zimmer

IGC Proceedings (1977-2023)

The performance of a grinding energy test for the simple and rapid prediction of crude fibre content in spring growth of grassland was investigated during three successive years and its potential for deriving recommendations on appropriate cutting dates demonstrated. The grinding energy test appeared to achieve a precision comparable to that for near infrared based predictions of crude fibre reported from the literature. Prediction bias consisting in a mean 2% crude fibre underestimation was found to occur in one year presumably due to an anomalous _constellation of environmental conditions. This appeared to have affected the pattern of plant development and …

Cell Wall Composition And Rate Of Digestion Of Brown-Midrib Sorghum Internodes As Influenced By Maturity, J H. Cherney, J J. Volenec, K J. Moore

IGC Proceedings (1977-2023)

More information is needed on the growth of secondary plant cell walls in forage species, and the relationship of cell wall structure to rate and extent of digestion. Our overall objective was to relate changes in cell wall composition with maturation to rate and extent of cell wall digestion. The seventh intemode of normal and brown-midrib ( bmr) sorghum (Sorghum bicolor (L.) Moench.) was harvested at eight maturities beginning with the cessation of intemode elongation. Dry weight per segment was determined for each maturity stage. Lignin accumulation in lntemode 7 increased during maturation, with the rate of lignin synthesis being …

The Effect Of The Species, Stage Of Maturity And Level Of Intake Of Grass On The Efficiency Of Microbial Protein Synthesis In The Rumen Of Cattle, F J. Hart, Jane Leibholz

IGC Proceedings (1977-2023)

This study was undertaken because there is a paucity of information in the literature on the efficiency of microbial protein synthesis in the rumen of cattle when grass is fed as the sole diet. There is also little experimental data available on the factors which affect the efficiency of microbial protein synthesis. The work involved feeding six rumen fistulated Friesian steers with three species of grass which were harvested at various tages of maturity. In addition each maturity of forage was fed at three 15levels of orp5 nic matter ( OM) intake.

as sampled at the omasum and microbial protein …

The Influence Of Aging On Forage Quality Of Individual Switchgrass Leaves And Stems, B Anderson

IGC Proceedings (1977-2023)

Cattle selectrively graze switchgrass (Panicum virgatum L.) tops prior to the boot stage and prefer vegetative culms and new tillers following heading. Therefore, a study was conducted to evaluate the changes in forage composition of individual leaves and stems during growth to determine if grazing selection may be influenced by aging. Plants were cut periodically at ground level from collaring of the first leaf until anthesis. Leaves (leaf blade plus sheath) of different ages, stems, and the whorl were hand separated at each harvest. Crude protein, in vitro dry matter disappearance (IVDMD), neutral and acid detergent fiber, lignin, and …

Harvesting Alyceclover For Maximum Dry Matter Yield And Nutrient Value, D D. Baltensperger, W G. Blue, W H. Anderson

IGC Proceedings (1977-2023)

Limited information is available on the quality of alyceclover (Alysicarpus vaginalis) in relation to plant stress. This study was undertaken to clarify the relationship between plant maturity and forage yield, quality and mineral composition in order to optimize each at harvest. Alyceclover was grown for two summers and new plots were harvested weekly through the pod-fill stage of development beginning eight weeks after planting. Samples were analyzed for dry matter, organic matter, In vitro dry matter digestibility, nitrogen, phosphorus, potassium, calcium, magnesium, manganese, copper, iron and zinc. Dry matter yields increased through the flowering stage of development except …

Adaptation Of The Inra System Of Determination And Expression Of The Nutritive Value Of Forages To The Tropical Conditions In The Caribbean Island, A Xande, R Garcia-Trujillo

IGC Proceedings (1977-2023)

This program have undertaken a series of trials of systematic measure of nu tritive value on the tropical forages. The choice of the calculation and of the way of expression of energetic and nitrogen values required comparation measures in different systems as well as attempts in alimentation before adopting the new french INRA system of energy (UFL-UFV) and of the protein value (POI). The general results of this study is a preamble to the diffusion of the table of nutritive value of the tropical forages. For this purpose 450 samples of forages have been analysed on sheep in cage of …

Protein Structure Influences Redox Stability, Oxygen Affinity, And Heat-Induced Denaturation Properties Of Bovine Myoglobin, Hemoglobin, And Cytochrome C, Anuj Sharma, Runnan Li, Silan Bhandari, Surendranath P. Suman, Sadagopan Krishnan, Morgan Pfeiffer, Gretchen Mafi, Ranjith Ramanathan

Animal and Food Sciences Faculty Publications

While past research has predominantly focused on the role of myoglobin in meat color, investigations into the contributions of hemoglobin and cytochrome c are limited. Cytochrome c has the highest redox stability (P < 0.05), followed by myoglobin and hemoglobin. Electrochemistry analysis revealed that cytochrome c has a greater capacity (P < 0.05) to reduce than myoglobin and hemoglobin. Differential scanning calorimetry indicates that cytochrome c was most stable to heat (P < 0.05), while no differences were noted between myoglobin and hemoglobin. Structural analysis noted that greater heat and redox stability of cytochrome c might be attributed to fewer histidine residues (3) and more covalent bonds (4) than myoglobin (13), hemoglobin α (10), and hemoglobin β (6). This study suggests that the amino acid sequence and number of covalent bonds can impact the redox stability and heat-induced denaturation properties of myoglobin, hemoglobin, and cytochrome c.

New Synthetic Resorbable Mesh For Open Ventral Hernia Repair, J. Scott Scott Roth, Bruce Ramshaw, Yohann Renard, G. Passot, Frederik Berrevoet, Katie Bayliss, Marion Blanc, Charles Cain, Matthew Goldblatt

Surgery Faculty Publications

Introduction Ventral hernia repair is among the most commonly performed general surgical procedures, during which meshes are often used to provide further support to weakened or damaged tissue surrounding the hernia repair site. Slowly resorbable synthetic meshes have recently emerged as a valid choice, as confirmed by published clinical evidence on launched meshes in the repair of ventral hernias showing satisfactory results. This study was designed to assess the performance and safety of a newly developed slowly fully resorbable self-gripping synthetic mesh in patients undergoing ventral hernia repair through open surgery in clean and clean-contaminated fields. Methods and analysis This …

The International Soft Tissue Sarcoma Consortium, Gianni Bisogno, Monika Sparber-Sauer, David Rodeberg, Johannes H.M. Merks, Ewa Koscielniak, Suzanne L. Wolden, Gian Luca De Salvo, Paola Del Bianco, Wei Xue, Martin Ebinger, Christian Vokuhl, Rajkumar Venkatramani, Samuel L. Volchenboum, Brian Furner, Veronique Minard Colin, Douglas S. Hawkins

Surgery Faculty Publications

Background: The International Soft Tissue Sarcoma Consortium (INSTRuCT) was established in 2017 to enhance international collaboration. This study describes the characteristics of rhabdomyosarcoma (RMS) patients in the INSTRuCT database and examines differences across contributing groups. Methods: INSTRuCT includes data Children’s Oncology Group (COG), Cooperative Weichteilsarkom Studiengruppe (CWS), and European Paediatric Soft Tissue Sarcoma Study Group (EpSSG) along with prior studies from Malignant Mesenchymal Tumour Committee (MMT) and Italian Soft Tissue Sarcoma Committee (STSC). Data standardization was supported by the University of Chicago’s Pediatric Cancer Data Commons. Pseudonymized patient-level data from clinical trials were harmonized. Differences across groups were assessed using …

The Kentucky Microbiome Dataset, Rachel L. Washburn, Douglas C. Curl

Research Data--KGS

The Kentucky Microbiome Dataset is a continuously updated geolocated dataset which describes the distribution and diversity of microorganisms across the Commonwealth of Kentucky. Each geolocated point represents a location reported in the peer-reviewed literature where microorganisms were sampled from soil, water, geologic substrates, or clinical settings. Environmental studies include only non-host-associated, non-clinical microorganisms sampled from natural environments. Clinical studies are mapped separately to highlight locations where investigations into host-associated or human health-related microbes have occurred.

For each location, associated metadata include study information, taxonomic classifications, sample type, sampling method, latitude and longitude, sampling date, publication reference, and a direct link …

Receptor-Mediated Spion Labeling Of Cd4+ T Cells For Longitudinal Mri Tracking Of Distribution Following Systemic Injection In Mouse, Yu Ping, Songyue Han, Brock Howerton, Francesc Marti, Jake Weeks, Roberto Gedaly, Reuben Adatorwovor, Fanny Chapelin

Surgery Faculty Publications

Tracking T cells in vivo using MRI is a major challenge due to the difficulty of labeling these non-phagocytic cells with a sufficient contrast agent to generate a detectable signal change. In this study, we explored CD4-Superparamagnetic iron oxide nanoparticles (SPION), which is commonly used in magnetic cell sorting, as a potential receptor-mediated, specific CD4+ T cell MRI labeling agent. We optimized the labeling protocol for maximal CD4+ cell labeling and viability. Cell health was confirmed with trypan blue assay, and labeling efficacy was confirmed with Prussian blue staining, transmission electron microscopy, and MRI of labeled cell pellets. Key cell …

Effects Of The Communities That Heal Intervention On Initiation, Retention, And Linkage To Medications For Opioid Use Disorder (Moud), Jennifer L Brown, Marc R Larochelle, Laura C Fanucchi, Deirdre C Calvert, Aimee N C Campbell, Redonna K Chandler, Daniel J Feaster, Lashawn M Glasgow, Erin B Gibson, Janae Holloway, Michelle R Lofwall, Aimee Mack, Nicole Mack, Edward V Nunes, Jeffery C Talbert, Sylvia Tan, Nathan Vandergrift, Jennifer Villani, Kat Asman, Hermik Babakhanlou-Chase, Sarah M Bagley, Tracy A Battaglia, Derek Blevins, Carly Bridden, Debbie M Cheng, Mia Christopher, Lindsay W Cogan, Chinazo O Cunningham

Biostatistics Faculty Publications

Medications for opioid use disorder (MOUD) can reduce opioid use and overdose deaths. This study examined whether the Communities That HEAL (CTH) intervention increased MOUD initiation, retention, and linkage. The HEALing Communities Study was a multi-site, 2-arm, parallel, community-level, cluster-randomized, unblinded, wait-list controlled trial conducted in 67 communities (n = 34 intervention, n = 33 control). Using Prescription Drug Monitoring Programs and Medicaid claims data, we compared mean community-level rates of MOUD outcomes during the 1-year comparison period (July 2021-June 2022) for: (a) MOUD receipt at least once; (b) continuous MOUD receipt for 180 days; and (c) MOUD linkage within …

The Timing And Significance Of Mid-Crustal Shearing And Exhumation Of Amphibolite-Facies Rocks Along The Great Glen Fault Zone, Scotland, Richard D. Law, J. Ryan Thigpen, Calvin A. Mako, Andrew Kylander-Clark, Mark J. Caddick, Lowell R. Moore, Cassandra Becker, Robert E. Holdsworth, Robin A. Strachan, A. Graham Leslie

Earth and Environmental Sciences Faculty Publications

The Rosemarkie Inlier lies on the NW side of the Great Glen Fault Zone (GGFZ) and is composed of foliated and lineated Archean orthogneisses and Moine metasedimentary rocks. The mylonitic foliation strikes NE–SW (parallel to the GGFZ), dips steeply SE and contains a gently to moderately plunging mineral lineation. Microstructural and quartz c-axis fabric analyses indicate that oblique sinistral shearing occurred under amphibolite-facies conditions. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) analyses on monazite rims in the gneisses yielded ²⁰⁶Pb/²³⁸U ages of 401.8 ± 4.8 Ma (including 2 (Formula presented.) uncertainty and a propagated additional 1% …

Map Of The Thickness Of Ordovician Shales Across The Kentucky-Tennessee Mineral District (Ktmd), John B. Hickman, Alex M. Washburn, Georgina Lukoczki

Research Data--KGS

The deposits of critical minerals have been found in metalliferous shales. To aid in critical mineral assessments of the Ordovician Shales in the Kentucky-Tennessee Mineral District (KTMD), this research project produced a map (digital GIS dataset) of the thickness (isopach) of the combined Upper Ordovician shale interval across the region. The subsurface input data are from oil/gas well records and exploratory mineral core. Well and core records for the KTMD were acquired from the state surveys of Tennessee and Kentucky. Along with the GIS files, a summary table of the 594 well and core data points used to produce this …

Balancing Infrastructure Demands: Analysis Of Materials Pricing And Supply, Bethany Paris, Ying Li, Steve Waddle, Bryan Gibson

Kentucky Transportation Center Research Report

The Kentucky Transportation Cabinet (KYTC) lets around 700 contracts year valued at over $1 billion. One of KYTC’s foremost goals is to deliver projects on time and on budget. However, over the past five years achieving these twin goals has grown in difficulty due to material shortages, widespread inflation, supply chain disruptions, and the tight labor market triggered by the COVID-19 pandemic. Although material shortages have abated and supply chain disruptions have eased, instability is seemingly a permanent feature of the national and global economies. As such, Cabinet decision makers need reliable tools that can be used to understand historical …

Adverse Birth Outcomes Associated With Heat Stress And Wildfire Smoke Exposure During Preconception And Pregnancy, Roxana Khalili, Yisi Liu, Yan Xu, Karl O’Sharkey, Nathan Pavlovic, Crystal Mcclure, Fred Lurmann, Tingyu Yang, Xinci Chen, Mario Vigil, Brendan Grubbs, Layla Al Marayati, Deborah Lerner, Nathana Lurvey, Carmen J. Marsit, Jill Johnston, Theresa M. Bastain, Carrie V. Breton, Shohreh F. Farzan, Rima Habre

Epidemiology and Environmental Health Faculty Publications

We investigated associations between preconception and prenatal heat stress and wildfire (WF) smoke exposures on adverse birth outcomes and whether neighborhood climate vulnerability is an effect modifier in the Maternal And Developmental Risks from Environmental and Social stressors cohort (N = 713). Generalized linear models were fit to test the association between exposures and small-for-gestational-age (SGA), low birthweight (LBW), and Fenton growth z-score outcomes, adjusting for confounders. Living in a high climate vulnerability index neighborhood was tested as an effect modifier. During preconception, increases in heat stress and WF measures were associated with higher odds of SGA. Living in the …

Associations Of Hepatitis C Virus (Hcv) Antibody Positivity With Opioid, Stimulant, And Polysubstance Injection Among People Who Inject Drugs (Pwid) In Rural U.S. Communities, Angela T. Estadt, William C. Miller, David Kline, Bridget M. Whitney, April M. Young, P. Todd Korthuis, Thomas J. Stopka, Judith Feinberg, William A. Zule, Mai T. Pho, Peter D. Friedmann, Ryan P. Westergaard, Kellene V. Eagen, Andrew Seaman, Jimmy Ma, Vivian F. Go, Kathryn E. Lancaster

Epidemiology and Environmental Health Faculty Publications

Background: People who inject drugs (PWID) in the rural U.S. often inject stimulants, alone or with opioids. The impact of these substance use patterns may influence HCV risk behaviors. This analysis examines the associations of HCV antibody positivity with injecting only opioids, only stimulants (methamphetamine/cocaine), and opioids and stimulants together among rural PWID. Methods: The Rural Opioid Initiative (ROI) consists of eight research sites that enrolled people who use drugs in rural communities in ten U.S. states from 2018 to 2020. This cross-sectional analysis included adult participants who resided in a study area and injected any drug in the past …

The Effects Of Parental Occupational Exposures On Autism Spectrum Disorder Severity And Skills In Cognitive And Adaptive Domains In Children With Autism Spectrum Disorder, Erin C. Mccanlies, Ja Kook Gu, Claudia C. Ma, Wayne T. Sanderson, Yunin J. Ludeña-Rodriguez, Irva Hertz-Picciotto

Epidemiology and Environmental Health Faculty Publications

No abstract provided.

Light-Driven Phenotypic Plasticity In The Depth-Generalist Coral, Pavona Varians, Claire J. Lewis, Shayle B. Matsuda, Tayler L. Sale, Caitlyn Genovese, Chelsea S. Wolke, Norton Chan, Stephen Ranson, Jake M. Ferguson, Amy L. Moran, David A. Gulko, Peter B. Marko

Biology Faculty Publications

Climate change is causing shifts in the spatial distribution of species and a reshuffling of the composition of multiple community types. On coral reefs, deep water can act as both refuges and refugia for corals from the combined negative effects of heat and light stress. Phenotypically plastic generalists that can tolerate both low and high light environments could be disproportionately important on future reefs, persisting in refugia and colonizing vacant shallow reefs. We performed a common garden experiment to investigate the effect of light on three different wild-collected genotypes of the abundant, depth-generalist coral Pavona varians. We measured the growth …

Enhanced Pavement Project Prioritization, Bryan Gibson, Jon Wilcoxson, Gayle Marks

Kentucky Transportation Center Research Report

The Kentucky Transportation Cabinet (KYTC) is responsible for inspecting, maintaining, and improving 27,000 centerline miles of pavement. Given the vastness of the state’s transportation network, KYTC needs a robust method for prioritizing pavement preservation projects. The Cabinet has relied on pavement condition ratings, data collected using Laser Crack Measurement Systems, and input from district-level staff to prioritize these types of projects. But this approach overlooks information that should be considered, such as factors related to safety, mobility, and geographic context. To resolve these shortcomings, Kentucky Transportation Center (KTC) researchers worked with KYTC subject-matter experts to develop the Enhanced Pavement Prioritization …

Stabilizing Embankments Using Geosynthetic Reinforcement, Daryl Greer, Charlie Sun

Kentucky Transportation Center Research Report

Reinforced soil slopes (RSSs) can be a feasible solution for embankments where there exist right of way re-strictions, environmental issues, rolling or mountainous topography, unfavorable geology, and other limiting fac-tors. They can be an alternative to retaining walls or importing select fills to construct steeper, stable embankment slopes where flatter embankment slopes may result in unwanted impacts, costs, and maintenance issues. Thisreport discusses the advantages and limitations of using geosynthetic reinforcement to construct RSSs. Researchers investigated current design, specification, and construction practices to determine which practices can be adopted by the Kentucky Transportation Cabinet (KYTC). Specifications were developed for using …

Thickness Of Devonian Shale, Kentucky-Tennessee Mineral District (Ktmd), John B. Hickman, Alex M. Washburn, Georgina Lukoczki

Research Data--KGS

The deposits of critical minerals have been found in metalliferous shales. To aid in critical mineral assessments of the Devonian Shales in the Kentucky-Tennessee Mineral District (KTMD), this research project produced a map (digital GIS dataset) of the thickness (isopach) of the combined New Albany Shale/Chattanooga Shale/Ohio Shale interval across the region. The subsurface input data are from oil/gas well records and exploratory mineral core. Well and core records for the KTMD were acquired from the state surveys of Tennessee and Kentucky. Along with the GIS files, a summary table of the 6,607 well and core data points used to …

Mines Of The Illinois-Kentucky Fluorspar District, Paul Puckett, Emily Morris, Georgina Lukoczki

Map and Chart--KGS

This map presents a unified compilation of mining and mineral resource information for the Illinois-Kentucky Fluorspar District (IKFD), integrating two previously published maps: Denny et al. (2020) for the Illinois portion and Anderson and Sparks (2012) for the Kentucky portion. While the Illinois side remains unchanged, the Kentucky side has been updated using newly compiled data from the Kentucky Geological Survey’s Kentucky Mineral Resources Information map service (https://kgs.uky.edu/KYMineral/). This composite map offers an improved and more comprehensive view of the IKFD, highlighting mineral occurrences, historical mining activity, and structural features of the district.

Structure On The Top Of Knox Group, Kentucky-Tennessee Mineral District (Ktmd), John B. Hickman

Research Data--KGS

The deposits of critical minerals within the Kentucky-Tennessee Mineral District (KTMD) are hosted within the Late Cambrian to Early Ordovician carbonate rocks of the Knox Group. To aid in critical mineral assessments of the region, this research project produced a map (digital GIS dataset) of the subsurface structure of the top of the Knox Group: the Knox Unconformity surface. All the input data is from oil/gas well records and exploratory mineral core records because these rocks are not exposed within the study area. Well and core records for the KTMD were acquired from the state surveys of Tennessee and Kentucky …

Who Reconstitutes The Chemotherapy? The Educational And Practice Needs Of Oncology Pharmacists In West Africa: A Call For Multidisciplinary Team Approach In Oncology Care., Runcie C.W. Chidebe, Ramatu M. Alabelewe, Krishna Prasad Sapkota, Darlingtina K. Esiaka, Candidus C. Nwakasi, Gloria C. Okwu, Jacinta Emejulu, Adamu A. Umar, Ndifreke Okwuegbunam, Funsho David, Toyosi Adepoju, Agha A. Agha, Ejike S. Ugwu, Simeon C. Aruah, Richard Mshelia, Rob Duncombe, Noel N. Wannang, Peace C. Babalola, R. Donald Harvey, Cindy O'Bryant, Folakemi T. Odedina

Behavioral Science Faculty Publications

PURPOSE: Oncology pharmacists (OPs) play a crucial role in cancer care, treatment, survivorship, and multidisciplinary teams (MDTs). OPs have specialized training in designing, administering, monitoring, and modifying oncology chemotherapy; managing adverse events; and evaluating clinical trials and investigational drugs. Yet, the state of OP has remained largely unknown in the clinical oncology workforce of the West African region. Therefore, this study aimed to understand who reconstitutes chemotherapy and to explain the OP educational and practice needs, challenges, and solutions in Nigeria.

MATERIALS AND METHODS: Using a concurrent embedded mixed method design, 35 OPs completed a questionnaire, and 12 others responded …

Endothelium- And Fibroblast-Derived C-Type Natriuretic Peptide Prevents The Development And Progression Of Aortic Aneurysm, Aisah A. Aubdool, Amie J. Moyes, Cristina Perez-Ternero, Reshma S. Baliga, Jaspinder Singh Sanghera, M. Taaha Syed, Kareemah Jaigirdar, Anmolpreet K. Panesar, Janice C. Tsui, Yanming Li, Hernan G. Vasquez, Ying H. Shen, Scott A. Lemaire, Juliette Raffort, Ziad Mallat, Hong S. Lu, Alan Daugherty, Adrian J. Hobbs

Physiology Faculty Publications

BACKGROUND: Thoracic (TAA) and abdominal (AAA) aortic aneurysm are life-threatening diseases characterized by dilation, inflammation, and structural weakness; development of pharmacological therapies is desperately needed. CNP (C-type natriuretic peptide) plays a key role in vascular homeostasis, mediating vasodilator, anti-inflammatory, and antiatherogenic actions. Since such processes drive AA, we determined the role of endogenous CNP in offsetting pathogenesis. METHODS: Tissue from patients with AA was analyzed to determine the consequences on CNP signaling. Ascending and suprarenal aortic diameters were assessed at baseline and following Ang II (angiotensin II; 1.44 mg/kg per day) infusion in wild-type, endothelium-restricted (ecCNP^-/-), fibroblast-restricted (fbCNP …