Digital Commons Network^™

Seedling Emergence And Survival Of Iris Lactea. Var. Chinensis In Different Vegetations, Y. C. Sun, Z. M. Yang, Kun Wang

IGC Proceedings (1977-2023)

No abstract provided.

Germination Of Seeds Of Pennisetum Hybridum Cv. Paraiso Affected By Different Harvest Dates, Storage Periods And Sowing Depths, Valdinei T. Paulino, M. A. C. De Lucena, M. S. Bueno

IGC Proceedings (1977-2023)

No abstract provided.

Q134r: Small Chemical Compound With Nfat Inhibitory Properties Improves Behavioral Performance And Synapse Function In Mouse Models Of Amyloid Pathology, Pradoldej Sompol, Jenna L. Gollihue, Susan D. Kraner, Irina A. Artiushin, Ryan A. Cloyd, Emad Chishti, Shon A. Koren, Grant K. Nation, Jose F. Abisambra, Orsolya Huzian, Lajos I. Nagy, Miklos Santha, Laszlo Hackler Jr., Laszlo G. Puskas, Christopher M. Norris

Sanders-Brown Center on Aging Faculty Publications

Inhibition of the protein phosphatase calcineurin (CN) ameliorates pathophysiologic and cognitive changes in aging rodents and mice with aging-related Alzheimer's disease (AD)-like pathology. However, concerns over adverse effects have slowed the transition of common CN-inhibiting drugs to the clinic for the treatment of AD and AD-related disorders. Targeting substrates of CN, like the nuclear factor of activated T cells (NFATs), has been suggested as an alternative, safer approach to CN inhibitors. However, small chemical inhibitors of NFATs have only rarely been described. Here, we investigate a newly developed neuroprotective hydroxyquinoline derivative (Q134R) that suppresses NFAT signaling, without inhibiting CN activity. …

Effect Of The Lysosomotropic Agent Chloroquine On Mtorc1 Activation And Protein Synthesis In Human Skeletal Muscle, Michael S. Borack, Jared M. Dickinson, Christopher S. Fry, Paul T. Reidy, Melissa M. Markofski, Rachel R. Deer, Kristofer Jennings, Elena Volpi, Blake B. Rasmussen

Athletic Training and Clinical Nutrition Faculty Publications

BACKGROUND: Previous work in HEK-293 cells demonstrated the importance of amino acid-induced mTORC1 translocation to the lysosomal surface for stimulating mTORC1 kinase activity and protein synthesis. This study tested the conservation of this amino acid sensing mechanism in human skeletal muscle by treating subjects with chloroquine-a lysosomotropic agent that induces in vitro and in vivo lysosome dysfunction.

METHODS: mTORC1 signaling and muscle protein synthesis (MPS) were determined in vivo in a randomized controlled trial of 14 subjects (10 M, 4 F; 26 ± 4 year) that ingested 10 g of essential amino acids (EAA) after receiving 750 mg of chloroquine …

Acute-Onset Central Serous Retinopathy After Immunization With Covid-19 Mrna Vaccine, Nicholas Fowler, Noe R. Mendez Martinez, Bernardo Velazquez Pallares, Ramiro S. Maldonado

Ophthalmology and Visual Science Faculty Publications

Purpose
We report the case of a 33-year-old male who presented with unilateral central serous retinopathy three days after the injection of a COVID-19 vaccine.

Observations
A 33-year-old healthy Hispanic male referred to the ophthalmology service due to blurry vision and metamorphopsia in the right eye without any flashes, floaters, eye redness or pain. The patient reported that 69 hours prior to presentation he received the first dose of the Pfizer-BioNTech BNT162b2 mRNA COVID-19 vaccine. He denied any past ocular history or pertinent medical history. He does not take any medicines and denies stressful factors in his life. The clinical …

The Design Of The N2edm Experiment, N. J. Ayres, G. Ban, L. Bienstman, G. Bison, K. Bodek, V. Bondar, T. Bouillaud, E. Chanel, J. Chen, P.-J. Chiu, B. Clément, C. B. Crawford, M. Daum, B. Dechenaux, C. B. Doorenbos, S. Emmenegger, L. Ferraris-Bouchez, M. Fertl, A. Fratangelo, P. Flaux

Physics and Astronomy Faculty Publications

We present the design of a next-generation experiment, n2EDM, currently under construction at the ultracold neutron source at the Paul Scherrer Institute (PSI) with the aim of carrying out a high-precision search for an electric dipole moment of the neutron. The project builds on experience gained with the previous apparatus operated at PSI until 2017, and is expected to deliver an order of magnitude better sensitivity with provision for further substantial improvements. An overview is of the experimental method and setup is given, the sensitivity requirements for the apparatus are derived, and its technical design is described.

Donnan Potential Across The Outer Membrane Of Gram-Negative Bacteria And Its Effect On The Permeability Of Antibiotics, Olaniyi Alegun, Ankit Pandeya, Jian Cui, Isoiza Ojo, Yinan Wei

Chemistry Faculty Publications

The cell envelope structure of Gram-negative bacteria is unique, composed of two lipid bilayer membranes and an aqueous periplasmic space sandwiched in between. The outer membrane constitutes an extra barrier to limit the exchange of molecules between the cells and the exterior environment. Donnan potential is a membrane potential across the outer membrane, resulted from the selective permeability of the membrane, which plays a pivotal role in the permeability of many antibiotics. In this review, we discussed factors that affect the intensity of the Donnan potential, including the osmotic strength and pH of the external media, the osmoregulated periplasmic glucans …

Equity-Oriented Conceptual Framework For K-12 Stem Literacy, Christa Jackson, Margaret J. Mohr-Schroeder, Sarah B. Bush, Cathrine Maiorca, Thomas Roberts, Caitlyn Yost, Abigail Fowler

Science, Technology, Engineering, and Mathematics (STEM) Education Faculty Publications

We introduce a conceptual framework of K-12 STEM literacy that rightfully and intentionally positions each and every student, particularly minoritized groups, as belonging in STEM. In order to conceptualize the equity-based framework of STEM literacy, we conducted a systematic review of literature related to STEM literacy, which includes empirical studies that contribute to STEM literacy. The literature on the siloed literacies within STEM (i.e., science, technology, engineering, and mathematics literacy) also contributed to formulate the necessity of and what it means to develop STEM literacy. The Equity-Oriented STEM Literacy Framework illuminates the complexities of disrupting the status quo and rightfully …

Role Of Soil Seed Bank On Persistency Of Pastures In Tropical Grasslands Of Kangayam, S. Natarajan, B. K. Trivedi, Anil Kumar, Nagaratna Biradar, P. S. Pathak

IGC Proceedings (1977-2023)

No abstract provided.

Analyses On Seed Yield Components Of Setaria Sphacetata Cv. Narok, Xinhui Duan, Qiaoxian Li, Shiming Xue, Bizhi Huang

IGC Proceedings (1977-2023)

No abstract provided.

Experimental Study On Sowing Seeds By Air‐Stream Metering Mechanism, Zhonghua Li, Decheng Wang, Guilin Liu

IGC Proceedings (1977-2023)

No abstract provided.

Effects Of Different Plant Density On Seed Yield Of Mongolia Wheatgrass, Zhong Zhang, Jinfeng Yun, Chao Wen, Aijiao Cui

IGC Proceedings (1977-2023)

No abstract provided.

Effect Of Combined Fertilization On Seed Production Of Xinnong‐1 Bermudagrass, Yanhui Zhang, Abulaiti, Peiying Li

IGC Proceedings (1977-2023)

No abstract provided.

Models For The Peak Value Of Mixed Grasshopper Population Density In Ganjia Of Gansu, China, Xiaoni Liu, D. G. Zhang, W. L. Jiang

IGC Proceedings (1977-2023)

No abstract provided.

Effects Of Water Stress On The Pro And Cat Characteristics In Forage Seedling Stage, Jianning Liu, Yunqi Wang, Xinning Wu, Yonghong Shi, Pu Guo

IGC Proceedings (1977-2023)

No abstract provided.

Effects Of Agricultural Measures On Insect Diversity Of Alfalfa, Changzhong Liu

IGC Proceedings (1977-2023)

No abstract provided.

Algebraic Graph-Assisted Bidirectional Transformers For Molecular Property Prediction, Dong Chen, Kaifu Gao, Duc Duy Nguyen, Xin Chen, Yi Jiang, Guo-Wei Wei, Feng Pan

Mathematics Faculty Publications

The ability of molecular property prediction is of great significance to drug discovery, human health, and environmental protection. Despite considerable efforts, quantitative prediction of various molecular properties remains a challenge. Although some machine learning models, such as bidirectional encoder from transformer, can incorporate massive unlabeled molecular data into molecular representations via a self-supervised learning strategy, it neglects three-dimensional (3D) stereochemical information. Algebraic graph, specifically, element-specific multiscale weighted colored algebraic graph, embeds complementary 3D molecular information into graph invariants. We propose an algebraic graph-assisted bidirectional transformer (AGBT) framework by fusing representations generated by algebraic graph and bidirectional transformer, as well as …

Aerosolized Surfactant For Preterm Infants With Respiratory Distress Syndrome, Mandy Brasher, Thomas M. Raffay, M. Douglas Cunningham, Elie G. Abu Jawdeh

Pediatrics Faculty Publications

Currently, the administration of surfactant to preterm infants with respiratory distress syndrome (RDS) mainly relies on intratracheal instillation; however, there is increasing evidence of aerosolized surfactant being an effective non-invasive strategy. We present a historical narrative spanning sixty years of development of aerosolization systems. We also offer an overview of the pertinent mechanisms needed to create and manage the ideal aerosolization system, with a focus on delivery, distribution, deposition, and dispersion in the context of the human lung. More studies are needed to optimize treatment with aerosolized surfactants, including determination of ideal dosages, nebulizer types, non-invasive interfaces, and breath synchronization. …

Effects Of Abiotic Stresses On Achnatherum Inebrians By Symbiotic Endophyte Of Neotyphodium Gansuense, Chunjie Li, Fei Li, Xiaoyuan Gou, Zhibiao Nan

IGC Proceedings (1977-2023)

No abstract provided.

Morphoagronomic And Isoenzymatic Characterization Of 23 Accessions Of Leucaena Spp, Hilda B. Wencomo Cárdenas, Alba Álvarez González, Leonor Mora López, Orlando Coto Arbelo, Maykelis Díaz Solares

IGC Proceedings (1977-2023)

No abstract provided.

Modelling The Effect Of Rangeland Management On Livestock Production System Of Nomads In Southern Iran, Gholamreza Badjian, Dahlan Ismail, Mohd. Shahwahid H. O., A. A. Mehrabi

IGC Proceedings (1977-2023)

No abstract provided.

Limitations In American Adults’ Awareness Of And Beliefs About Alcohol As A Risk Factor For Cancer, Marc T. Kiviniemi, Heather Orom, Jennifer L. Hay, Erika A. Waters

Health, Behavior & Society Faculty Publications

Alcohol is a carcinogen. Recommendations to reduce alcohol use to lower cancer risk are increasingly common. However, neither the beliefs of US adults about alcohol consumption and cancer risk, nor factors influencing those beliefs, are well understood. We used data from the 2019 Health Information National Trends Survey (analysis N = 4,470) to examine beliefs about whether drinking too much alcohol increases cancer risk. We compared those beliefs to beliefs for three other health problems, and examined whether believing alcohol is a cancer risk factor was related to demographics, risk perceptions, other beliefs about the nature of cancer, and alcohol …

Cd151 Drives Cancer Progression Depending On Integrin Α3Β1 Through Egfr Signaling In Non-Small Cell Lung Cancer, Jianjie Zhu, Tingting Cai, Jieqi Zhou, Wenwen Du, Yuanyuan Zeng, Ting Liu, Yulong Fu, Yue Li, Qian Qian, Xiuwei H. Yang, Qinglin Li, Jian-An Huang, Zeyi Liu

Pharmacology and Nutritional Sciences Faculty Publications

Background
Tetraspanins CD151, a transmembrane 4 superfamily protein, has been identified participating in the initiation of a variety of cancers. However, the precise function of CD151 in non-small cell lung cancer (NSCLC) remains unclear. Here, we addressed the pro-tumoral role of CD151 in NSCLC by targeting EGFR/ErbB2 which favors tumor proliferation, migration and invasion.

Methods
First, the mRNA expression levels of CD151 in NSCLC tissues and cell lines were measured by RT-PCR. Meanwhile, CD151 and its associated proteins were analyzed by western blotting. The expression levels of CD151 in NSCLC samples and its paired adjacent lung tissues were then verified …

Diversity Of Desert Rodent Communities Under Different Disturbances And Scales In Alashan Desert, Inner Mongolia, Heping Fu, Xiaodong Wu, Fushun Zhang

IGC Proceedings (1977-2023)

No abstract provided.

Forage Yield Of Grass And Legume Entries In The Establishing Year In A Dry Tropical Area, Enrique Cortés-Díaz, Angel Ramon‐Garay, Fernando Tellez‐Hernández, José L. Zaragoza-Ramírez, Pedro A. Martínez-Hernández

IGC Proceedings (1977-2023)

No abstract provided.

Different Reactions Of Plants And Insect Taxa To Reduction Of Stocking Rate: A Concrete Reason To Promote Habitat Heterogeneity In Grazing Systems, Bertrand Dumont, Anne Farruggia, J.-P. Garel

IGC Proceedings (1977-2023)

No abstract provided.

Report Of The Pathogenesis And Pathophysiology Of Lyme Disease Subcommittee Of The Hhs Tick Borne Disease Working Group, Sam T. Donta, Leith J. States, Wendy A. Adams, Troy Bankhead, Nicole Baumgarth, Monica E. Embers, Robert B. Lochhead, Brian Stevenson

Microbiology, Immunology, and Molecular Genetics Faculty Publications

An understanding of the pathogenesis and pathophysiology of Lyme disease is key to the ultimate care of patients with Lyme disease. To better understand the various mechanisms underlying the infection caused by Borrelia burgdorferi, the Pathogenesis and Pathophysiology of Lyme Disease Subcommittee was formed to review what is currently known about the pathogenesis and pathophysiology of Lyme disease, from its inception, but also especially about its ability to persist in the host. To that end, the authors of this report were assembled to update our knowledge about the infectious process, identify the gaps that exist in our understanding of …

Opportunities To Improve Symptom Control With Somatostatin Congeners In Gep-Nets: A Review Of Key Issues, Lowell B. Anthony, Thomas M. O'Dorisio

Internal Medicine Faculty Publications

Octreotide acetate (octreotide) is the most prescribed and most studied somatostatin congener, or analog, for gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and carcinoid syndrome, the latter of which may be characterized by debilitating diarrhea and flushing. Approved in the U.S. more than 30 years ago, octreotide is widely used to control the symptoms of carcinoid syndrome and has been shown to demonstrate antiproliferative activity. The two formulations available in the U.S. include a subcutaneous immediate-release (IR) injection introduced in 1989 and a long-acting repeatable (LAR) intramuscular injection approved in 1999. Lanreotide depot (lanreotide), a more recent somatostatin congener, has been available in …

Impact Of Tillage System On Root‐Invading Fungi Of Winter Wheat In The Loess Plateau, T. Y. Duan, Zhibiao Nan, L. Y. Xie, Y. Y. Shen, C. J. Li

IGC Proceedings (1977-2023)

No abstract provided.

Overcoming Biological, Political And Social Obstacles To Achieve Effective Integrated Management Of Harmful Organisms In Rangelands, Robert E. Wilson

IGC Proceedings (1977-2023)

No abstract provided.