Digital Commons Network^™

Innovative Computational Methods For Pharmaceutical Problem Solving A Review Part I: The Drug Development Process, Heather R. Campbell, Robert A. Lodder

Pharmaceutical Sciences Faculty Publications

Computational methods have provided pharmaceutical scientists and engineers a means to go beyond what's possible with experimental testing alone. Providing a means to study active pharmaceutical ingredients (API), excipients, and drug interactions at or near-atomic levels. This paper provides a review of this and other innovative computational methods used for solving pharmaceutical problems throughout the drug development process. Part one of two this paper will emphasize the role of computational methods and game theory in solving pharmaceutical challenges.

Unicompartmental Knee Arthroplasty Is Associated With A Lower Rate Of Periprosthetic Joint Infection Compared To Total Knee Arthroplasty, Cody S. Lee, Edwin P. Su, Michael B. Cross, Alberto V. Carli, David C. Landy, Brian P. Chalmers

Orthopaedic Surgery and Sports Medicine Faculty Publications

Background: Several studies have reported lower perioperative complications with unicompartmental knee arthroplasty (UKA) than with total knee arthroplasty (TKA). However, there is a paucity of data analyzing the incidence of periprosthetic joint infection (PJI) in similar patients undergoing UKA and TKA. As such, we sought to analyze the incidence of UKA and TKA PJI in a large matched population.

Material and Methods: The Mariner data set of the PearlDiver database was queried for all patients undergoing UKA or TKA during 2010-2017. Included patients were required to have at least 2 years of database inclusion after surgery. Patients were then matched …

Interprofessional Inconsistencies In The Diagnosis Of Shoulder Instability: Survey Results Of Physicians And Rehabilitation Providers, Constantine P. Nicolozakes, Xinning Li, Timothy L. Uhl, Guido Marra, Nitin B. Jain, Eric J. Perreault, Amee L. Seitz

Physical Therapy Faculty Publications

Background: Clinicians of many specialties within sports medicine care for athletes with shoulder instability, but successful outcomes are inconsistent. Consistency across specialties in the diagnosis of shoulder instability is critical for care of the athlete, yet the extent of divergence in its diagnosis is unknown.

Hypothesis: Physicians differ from rehabilitation providers in which findings they deem clinically important to differentiate shoulder instability from impingement, and in how they diagnose athlete scenarios with atraumatic shoulder instability.

Study Design: Cross-sectional study.

Methods: Physicians (orthopaedic surgeons, primary care sports medicine physicians) and rehabilitation providers (physical therapists, athletic trainers) were asked via an online …

Evaluating The Safety Cultures Of Kentucky Transportation Cabinet Maintenance Crews, Ashtarout Ammar, Zamaan Al-Shabbani, Hala Nassereddine, Chris Van Dyke, Gabriel B. Dadi

Kentucky Transportation Center Research Report

Highway work zones can be dangerous and unpredictable. Between 2003 and 2017, over 1,800 workers died on road construction sites. Eliminating injuries and deaths requires state transportation agencies to adopt robust safety cultures as there is a clear relationship between these cultures and worker behaviors. The Kentucky Transportation Cabinet (KYTC) is committed to improving safety performance by nurturing a positive safety climate among highway maintenance crews. To understand the safety cultures of KYTC maintenance crews, researchers administered a survey based on the Safety Climate Assessment Tool (S-CAT) developed by the Center for Construction Research and Training (CPWR). This is the …

The Battle Over Cattle: Livestock Management In A Changing Rural Landscape, Monique Salomon, Robert Fincham, Terry Everson

IGC Proceedings (1977-2023)

No abstract provided.

Recent Innovations In Education‐Extension‐Research Networks Of Industrialised Agricultures, Mark Paine, Marianne Cerf

IGC Proceedings (1977-2023)

No abstract provided.

Llama De Ayopaya: Towards Marketing Of High Quality Fine Fibre In The Bolivian Andes, M. Siegmund‐Schultze, J. Delgado, A. Stemmer, A. Markemann, A. Valle Zárate

IGC Proceedings (1977-2023)

No abstract provided.

Tropical Forages For Monogastric Animals: Enhancing Smallholders Competitiveness In Local And Emerging Markets, Michael Peters, D. White, L. S. Muñoz, P. Sarria, N. Vivas, F. Holmann, M. Lundy, T. Oberthur, P. Lentes, A. Schmidt, Martin Mena, S. Fujisaka

IGC Proceedings (1977-2023)

No abstract provided.

Emerging Market Trends Of Organic Food In Australia, C. Faiello, Andrea Pardini, L. Litjens

IGC Proceedings (1977-2023)

No abstract provided.

Sustaining Pastoral Linkages To High‐Value Livestock Markets Through Collective Action And Public‐Private Partnerships: A Case Study From Southern Ethiopia, S. Desta, D. Layne Coppock, G. Gebru, S. Tezera, L. Gizachew

IGC Proceedings (1977-2023)

No abstract provided.

Field Safety Experience With An Autologous Cancer Vaccine In Tumor-Bearing Cats: A Retrospective Study Of 117 Cases (2015-2020), Michael D. Lucroy, Alexa M. Kugler, Ferris El-Tayyeb, Ryan M. Clauson, Ashley E. Kalinauskas, Mark A. Suckow

Office of the Attending Veterinarian Academic Publications

OBJECTIVES: The aim of this study was to determine the frequency and severity of adverse events (AEs) reported from use of an adjuvanted whole-cell autologous cancer vaccine in cats with solid tumors under field conditions.

METHODS: The case accession database at Torigen Pharmaceuticals was searched to identify client-owned cats that underwent biopsy or surgical resection of their primary tumor, had histologic confirmation of neoplasia and received at least one subcutaneous dose of an adjuvanted whole-cell autologous cancer vaccine. Records were reviewed for any reported AEs.

RESULTS: In total, 117 cats met the inclusion criteria and received 422 doses of autologous …

Persistent Miscalibration For Low And High Achievers Despite Practice Test Feedback In An Introductory Biology Course, Jennifer L. Osterhage

Biology Faculty Publications

Students' ability to accurately judge their knowledge is crucial for effective learning. However, students' perception of their current knowledge is often misaligned with their actual performance. The relationship between learners' perception of their performance and their actual performance on a task is defined as calibration. Previous studies have shown significant student miscalibration in an introductory biology course: students' predicted exam scores were, on average, significantly higher than their actual scores. The goal of this study was to determine whether completion of a practice test before exams would result in better performance and calibration. The hypothesis was that students who completed …

A Distinct Difference Between Air And Mucosal Temperatures In Human Respiratory Tract, Mehdi Khosravi, Ruei-Lung Lin, Ashish P. Maskey, Subodh Pandey, An-Hsuan Lin, Lu-Yuan Lee

Internal Medicine Faculty Publications

xtensive evidence indicates that several types of temperature-sensitive ion channels are abundantly expressed in the sensory nerves innervating airway mucosa. Indeed, airway temperature is known to play an important role in regulating respiratory functions. However, the actual airway mucosal temperature and its dynamic changes during the respiratory cycle have not been directly measured. In previous studies, airway tissue temperature was often estimated by indirect measurement of the peak exhaled breath temperature (PEBT). In view of the poor thermal conductivity of air, we believe that the airway tissue temperature cannot be accurately determined by the exhaled air temperature, and this study …

The Challenges For Alfalfa Hay Marketing In China, Z. M. Yang

IGC Proceedings (1977-2023)

No abstract provided.

Stimulating Market Led Livestock Production Through Information Communication Technologies: Experiences From Pastoral Areas Of Eastern Africa, R. Kaitho, G. Kariuki, E. Kebebe, J. Gutta, J. Ndungu, M. Kingamkono, P. Dyke

IGC Proceedings (1977-2023)

No abstract provided.

Seed Performance Of Three Interespecific Hybrids Of Elephant Grass × Pearl Millet Under Controlled Deterioration, M. Pozitano, R. Usberti

IGC Proceedings (1977-2023)

No abstract provided.

Marketing Of Seeds Of Stylosanthes — A Tropical Legume In India, Nagaratna Biradar, K. Sridhar, C. R. Ramesh

IGC Proceedings (1977-2023)

No abstract provided.

What About The Rest Of Them? Fatal Injuries Related To Production Agriculture Not Captured By The Bureau Of Labor Statistics (Bls) Census Of Fatal Occupational Injuries (Cfoi), Bryan Weichelt, Erika Scott, Rick Burke, John Shutske, Serap Gorucu, Wayne T. Sanderson, Murray Madsen, Emily Redmond, Dennis J. Murphy, Risto Rautiainen

Biosystems and Agricultural Engineering Faculty Publications

Surveillance of injuries in production agriculture is necessary to inform stakeholders about workplace hazards and risks in order to improve and advance injury prevention policies and practices for this dangerous industry. The most comprehensive fatal injury surveillance effort currently in the United States is the Bureau of Labor Statistics (BLS) Census of Fatal Occupational Injuries (CFOI), which covers occupational fatalities in all U.S. industries, including production agriculture. However, this surveillance does not include many categories of fatalities that occur during agricultural work or on production agriculture worksites. To better capture the human cost of production agriculture, the authors of this …

Predictors Of Chronic Opioid Therapy In Medicaid Beneficiaries With Hiv Who Initiated Antiretroviral Therapy, Gyeon Oh, Emily S. Brouwer, Erin L. Abner, David W. Fardo, Patricia R. Freeman, Chris Delcher, Daniela C. Moga

Epidemiology and Environmental Health Faculty Publications

The factors associated with chronic opioid therapy (COT) in patients with HIV is understudied. Using Medicaid data (2002-2009), this retrospective cohort study examines COT in beneficiaries with HIV who initiated standard combination anti-retroviral therapy (cART). We used generalized estimating equations on logistic regression models with backward selection to identify significant predictors of COT initiation. COT was initiated among 1014 out of 9615 beneficiaries with HIV (male: 10.4%; female: 10.7%). Those with older age, any malignancy, Hepatitis C infection, back pain, arthritis, neuropathy pain, substance use disorder, polypharmacy, (use of) benzodiazepines, gabapentinoids, antidepressants, and prior opioid therapies were positively associated with …

Set1 Targets Genes With Essential Identity And Tumor-Suppressing Functions In Planarian Stem Cells, Prince Verma, Courtney K. M. Waterbury, Elizabeth M. Duncan

Biology Faculty Publications

Tumor suppressor genes (TSGs) are essential for normal cellular function in multicellular organisms, but many TSGs and tumor-suppressing mechanisms remain unknown. Planarian flatworms exhibit particularly robust tumor suppression, yet the specific mechanisms underlying this trait remain unclear. Here, we analyze histone H3 lysine 4 trimethylation (H3K4me3) signal across the planarian genome to determine if the broad H3K4me3 chromatin signature that marks essential cell identity genes and TSGs in mammalian cells is conserved in this valuable model of in vivo stem cell function. We find that this signature is indeed conserved on the planarian genome and that the lysine methyltransferase Set1 …

How Students And Principals Understand Classdojo: Emerging Insights, Daniela Kruel Digiacomo, Spencer P. Greenhalgh, Sarah C. Barriage

Information Science Faculty Publications

ClassDojo is a classroom communication and behavior management app intended to “bring every family into [the] classroom” (www.classdojo.com). The features of the platform include a points system to facilitate classroom management, instant teacher-parent communication (on the individual or class level), and student portfolios (among others). While ClassDojo claims to be used in over 95% of schools in the United States, there is little known about how students or principals interact with and understand the platform’s features and data. Drawing upon a mixed-methods study in a small state in the Southeastern United States, this article offers empirically driven insight …

Laser Irradiation As A Novel Alternative To Detach Intact Particulate Matter Collected On Air Filters, Seyed-Mohammadreza Samaee, Rahim Molaei, Robert A. Yokel, Hedieh Pazokian

Pharmaceutical Sciences Faculty Publications

Airborne particulate matter (PM) is collected on specific filters. For subsequent testing, the PM should be detached intact from the filter. Liquid extraction (LE), the standard method to detach PM from air filter surfaces, is challenging and can be tedious. Laser irradiation has been used to characterize PM on filters, but not to detach PM from filters for subsequent testing. A feasibility study was conducted to assess the potential of laser irradiation to detach PM from air filters. Laser-detached PM was deposited on a pre-weighed glass plate. PM detachment and collection were conducted in a single step. PM-coated air filters …

An Economic Assessment Of Cattle Raising Enterprises In The Red Soils Region Of China, Neil D. Macleod, Shilin Wen

IGC Proceedings (1977-2023)

No abstract provided.

Comparison Of Production And Cost Between Conventional And Organic Forage Crops, Jong-Duk Kim, C. H. Kwon, S. H. Chae, C. H. Kim

IGC Proceedings (1977-2023)

No abstract provided.

Market Trends For Organic Or Low Input Foods From Marginal Pastures, F. Longhi, Andrea Pardini

IGC Proceedings (1977-2023)

No abstract provided.

Fully Coupled Internal Radiative Heat Transfer For The 3d Material Response Of Heat Shield, Raghava S. C. Davuluri, Rui Fu, Kaveh A. Tagavi, Alexandre Martin

Mechanical Engineering Faculty Publications

The radiative transfer equation (RTE) is strongly coupled to the material response code KATS. A P-1 approximation model of RTE is used to account for radiation heat transfer within the material. First, the verification of the RTE model is performed by comparing the numerical and analytical solutions. Next, the coupling scheme is validated by comparing the temperature profiles of pure conduction and conduction coupled with radiative emission. The validation study is conducted on Marschall et al. cases (radiant heating, arc-jet heating, and space shuttle entry), 3D Block, 2D IsoQ sample, and Stardust Return Capsule. The validation results agree well for …

A Narrative Review On The Unexplored Potential Of Colostrum As A Preventative Treatment And Therapy For Diarrhea In Neonatal Dairy Calves, Havelah S. M. Carter, David L. Renaud, Michael A. Steele, Amanda J. Fischer-Tlustos, Joao H. C. Costa

Animal and Food Sciences Faculty Publications

Diarrhea is the leading cause of morbidity and mortality in pre-weaned dairy calves and, as such, represents a significant animal health and welfare concern. Furthermore, digestive disease early in life is associated with several long-term consequences such as reduced growth rate and decreased milk yield during the first lactation, thus generating severe economic losses. The majority of diarrheic cases in young calves are treated with antimicrobials; however, it is necessary to develop alternative treatments, as excessive antimicrobial usage can lead to antimicrobial resistance and can negatively impact the gut microflora of a calf. Bovine colostrum is abundant in immune and …

Integrating Kangaroos And Livestock Though Sustainable Wildlife Enterprise Trials, George R. Wilson

IGC Proceedings (1977-2023)

No abstract provided.

Using Kangaroos To Produce Low‐Emission Meat, George R. Wilson, Melanie Edwards

IGC Proceedings (1977-2023)

No abstract provided.

Institutional Innovations Of The Grassland Household‐Contract‐Responsibility System: A Study Of The Household‐Allied Operation System Of Xilinguole League, Inner Mongolia, Guanghua Qiao, Zhihua Xiao, Yanli Tian, Haichun Wang, Kaiguang Huang

IGC Proceedings (1977-2023)

No abstract provided.