Digital Commons Network^™

Fiber-Reinforced Composites For Vaginal Tissue Engineering Applications, Samyuktha S. Kolluru, Abir Hamdaoui, Annabella M. Mascot, Siobhan S. Sutcliffe, Jerry L. Lowder, Michelle L. Oyen, Samantha G. Zambuto

Mechanical Engineering Faculty Publications

The vagina is a fibromuscular tube-shaped organ that plays critical roles in menstruation, pregnancy, and female sexual health. Vaginal tissue constituents, including cells and extracellular matrix components, contribute to tissue structure, function, and prevention of injury and pathology. However, much microstructural function remains unknown, including how the fiber-cell and cell–cell interactions influence macromechanical properties. A deeper understanding of these interactions will provide critical information needed to reduce and prevent vaginal pathologies. Our objective for this work is to design a novel tissue-mimicking biomaterial for vaginal tissue engineering, and characterize its biological and mechanical performance in the vaginal microenvironment. We successfully …

First Water-To-Ligand Substitution Dictates Co2+/Ni2+ Extraction Selectivity, Kailong Zhang, Yuxuan Zhang, Bin Ji, Rick Q. Honaker, Isabel C. Escobar, Jian Shi, Qing Shao

Mining Engineering Faculty Publications

Solvent extraction is a crucial technology for the large-scale recovery of critical metals. One key challenge is to develop ligands with high ionic selectivity, especially for ions with similar properties. Manipulating ionic solvation emerges as a viable approach to enhance the selectivity. However, such manipulation requires a thorough understanding of the thermodynamics underlying ligand-induced variation in ionic solvation. We investigated the thermodynamics governing the binding of two organophosphorus ligands (Cyanex 272 and D2EHPA) with Co²⁺ and Ni²⁺ at the aqueous-organic liquid–liquid interface using a combination of experiments and computations. UV-vis and IR spectroscopy confirmed that extraction induces solvation …

Feasibility, Acceptability, And Preliminary Efficacy Of A Pilot Study To Integrate Buprenorphine Into A Harm-Reduction Drop-In-Center In Kampala, Uganda, Julia Dickson-Gomez, Sergey Tarima, Wamala Twaibu, Dan Katende, Latifah Kyeswa, Laura Glasman, Arthur Kiconco, Sarah Krechel, Bryan Johnston, Moses Ogwal, Brian Byamah Mutamba, Peter Mudiope, Stella Alamo, Rhoda Wanyenze, Geofrey Musinguzi

Biostatistics Faculty Publications

Illicit drug use has been increasing rapidly in Sub-Saharan Africa in the past decade. However, until recently HIV prevention has largely ignored people who inject drugs and medications to treat opioid use disorder (MOUD) were largely absent. This paper reports results of a pilot intervention that integrated buprenorphine into a harm-reduction drop-in-center for people with opioid use disorder (OUD) in Kampala, Uganda. We collected implementation outcomes and changes in self-reported drug use after buprenorphine initiation. We conducted qualitative interviews with a subset of 14 participants who had initiated buprenorphine. Sixty-two participants were screened for OUD, of whom 57 were eligible …

Artificial Intelligence In Biomedical Team Science: Perceptions, Practices, And Training Needs, Emily Slade, Kelsey N. Karnik, Caitline Phan, Megan E. Hall, Yana Feygin, Kristen J. Mcquerry

Biostatistics Faculty Publications

Introduction: Artificial intelligence (AI) is increasingly used in biomedical research, yet limited empirical work has described how researchers use AI tools on collaborative research teams and how they view their role within team-based research. This study examines researchers’ experience with and attitudes toward AI use in collaborative research environments.

Methods: A cross-sectional survey was administered to 178 investigators engaged in collaborative research at the University of Kentucky. Questions assessed AI use across research and communication tasks, team-related decision-making practices, perceived benefits and concerns, and preferences for training and frameworks.

Results: Thirty-nine participants responded (22%). AI use was heterogeneous: 26% had …

Dual Orexin Receptor Antagonism With Lemborexant Enhances Microglial Clearance Of Β-Amyloid In Mice, Ashish Sharma, Emiko Segawa, Xiaoying Chen, Sohui Park, Shoutang Wang, Riley E. Irmen, Nicholas J. Constantino, Chanung Wang, Michael F. Kanan, Marco Colonna, Shannon L. Macauley, Jocelyn Y. Cheng, Ken Hatanaka, Margaret Moline, Erik S. Musiek

Sanders-Brown Center on Aging Faculty Publications

Background: Sleep disturbances elevate brain amyloid-beta (Aβ) levels and represent a modifiable risk factor for Alzheimer’s disease (AD). The orexin/hypocretin system regulates sleep–wake behavior and has emerged as a therapeutic target in AD; however, the effects of FDA-approved dual orexin receptor antagonists (DORAs) on amyloid pathology remain unclear. We compared lemborexant, an FDA-approved DORA, to doxepin, an antihistaminergic sleep medication, on amyloid pathology and microglial responses in PSAPP mice.

Methods: PSAPP mice received lemborexant (10 or 30 mg/kg/day), doxepin (35 mg/kg/day), or vehicle for 6 weeks beginning prior to plaque onset or 4 weeks after established pathology. Sleep was assessed …

Effect Of Canagliflozin Pretreatment On The Efficacy Of Insulin Therapy To Rescue Type 1 Diabetes-Related Bone Fragility In Male Mice, Jeffry S. Nyman, R. Clay Bunn, Sasidhar Uppuganti, Elizabeth M. Hennen, Plaban Mishra, Philip D. Ray, Anthony Garcia Mendez, Evangelia Kalaitzoglou, John L. Fowlkes

Barnstable Brown Diabetes Center Faculty Publications

Humans with type 1 diabetes (T1D) have a higher-than-expected fracture risk, and bone is weak in mouse models of T1D. Since hyperglycemia is thought to deleteriously affect tissue-level sensitivity of insulin action, we hypothesized that glucose-lowering by canagliflozin (Cana) improves the ability of insulin treatment to rescue the T1D-related decrease in bone strength. To test this hypothesis, male DBA/2 mice with and without streptozotocin (STZ)-induced hyperglycemia at 8 weeks of age were fed a diet with and without Cana (50 ppm) at 10 weeks of age and then the T1D mice, regardless of placebo diet or Cana diet, were treated …

Emergency Department-Initiated Standard Versus High-Dose Buprenorphine Induction (Envision): A Randomised Clinical Trial Protocol, Kathryn Hawk, Andrew Herring, Marek Chawarski, Erik S. Anderson, Michael Baumann, Alyrene Dorey, August F. Holtyn, Christopher Jones, Shara Martel, Patricia Owens, Kaitlin Kmiecik, Tania D. Strout, Peter Taillac, Michelle R. Lofwall, Sharon L. Walsh, Gail D’Onofrio

Center on Drug and Alcohol Research Faculty Publications

Introduction: The initiation of buprenorphine for patients with opioid use disorder (OUD) in the emergency department (ED) has been associated with improved outcomes including reduced ED visits and increased treatment engagement. Though both standard-dose (8 mg buprenorphine equivalent) and high-dose (24 mg buprenorphine equivalent) strategies to initiate buprenorphine have been used in the ED, no prospective trials comparing outcomes among patients receiving these treatments have been reported.

Methods and analysis: This multisite randomised clinical trial is a multisite double-blind, double-dummy, randomised clinical trial enrolling 360 emergency department patients with moderate-to-severe OUD. Enrolled patients will be randomised to one of two …

Experiential Spillover In Public Views Of Police And Courts, Emma Henderson, Matthew Mettler, Jeffery J. Mondak, Mark Peffley

Political Science Faculty Publications

Personal experiences with public officials influence how those officials are perceived. We question whether these experiential effects extend to other officials. If people draw on what they know to make inferences about unfamiliar evaluative targets, then interactions with one actor may shape evaluations of other independent actors. Focusing on police and courts, analyses of data from two surveys reveal that personal interactions with public officials produce spillover effects on appraisals of officials in different sectors. The findings indicate that experiential spillover constitutes an underappreciated force in public opinion, one that operates outside the control of the actors being evaluated.

Facebook As A Strategy To Deliver A Peer Navigation Intervention For Recently Incarcerated Women With Opioid Use Disorder: A Mixed Methods Descriptive Profile, Martha Tillson, Jaxin Annett, Marguerite A. Webster, Amanda Fallin-Bennett, Mandi Webster, Amber Clemons, Cynthia Robinson, Kevin Crabtree, Casey Baker-Romans, Michele Staton

Center on Drug and Alcohol Research Faculty Publications

Recovery support and treatment linkages are critical during transitions from incarceration to community but can be challenging to deliver to hard-to-reach populations. This paper will examine Facebook contacts between peer navigators (PNs) and women with opioid use disorder (OUD) following jail release to explore women’s use of PN services, including purpose and content of Facebook messages. As part of a larger clinical trial under the Justice Community Opioid Innovation Network (JCOIN), PNs provided OUD treatment navigation and recovery support for 12 weeks following women’s release from jail, using remote options such as Facebook. Facebook Messenger transcripts between PNs and participants …

Evolution Of A Client‐Level Dataset: 20 Years Of National Child Traumatic Stress Network Data Collection, C. A. Purbeck, A. N. Cooke, L. J. Liang, C. Smith, J. Staten, J. Epstein, H. B. Hodgdon, Jessica Eslinger, A. Wells, J. Goodrich, T. H. Bethel, K. Willett, Y. C. Fu, J. A. Fairbank, E. C. Briggs

Center on Trauma and Children Faculty Publications

Objectives: For 20 years, the National Child Traumatic Stress Network's (NCTSN) data collection efforts have been a central mechanism for Clinical Quality Improvement (ClQI). The NCTSN is a federally funded initiative in the United States composed of programs dedicated to raising the standard of care and increasing access to services for children and families who have experienced traumatic events.

Methods: These efforts span three initiatives: the Core Data Set (CDS), the Clinical Improvement through Measurement Initiative (CIMI) Measurement Based Care (MBC), and CIMI Data Sharing (CIMI-DS) that collected and analyzed client-level data to improve care for children and families served …

Response Efficacy And Discrete Emotions In Message Design: Testing Emotional Pathways To Help-Seeking Intentions And Engagement, Marian Jaitto-Jeffrey

Theses and Dissertations--Communication

Research on fear appeals shows that threat-framed messages promote adaptive outcomes when accompanied by efficacy information. According to the extended parallel process model (EPPM), danger-control responses, including message acceptance, positive attitudes toward recommended behaviors, and help-seeking intentions, are most likely to occur when efficacy appraisals, particularly perceptions of response efficacy, are sufficient to meet perceived threat. When efficacy appraisals fall short of perceived threat, fear-control responses, such as message derogation, denial, or resistance to seeking help, are most likely to emerge. Beyond reducing defensive processing, response efficacy cues may also evoke positive emotions such as hope. Whereas fear is often …

Multiscale Modeling Of The Thermomechanical Behavior Of Polymeric And Molecular Organic Semiconductors, Kehinde H. Fagbohungbe

University of Kentucky Doctoral Dissertations

Organic semiconductors, derived from π-conjugated polymers and molecules, enable the development of deformable, stretchable and flexible electronics due to their tunable redox, optical, electronic and mechanical properties. However, an informed understanding of how multi-scale morphological characteristics of the polymeric and molecular semiconductors influence bulk properties that contribute to electronic and optical performance, especially under operational thermal and mechanical stresses, remains incomplete. This lack of understanding poses a challenge to scalability and commercialization of organic electronics. This dissertation develops and deploys computational modeling approaches, particularly atomistic molecular dynamics (MD) simulations, to investigate the multiscale morphological behavior of these synthetic semiconducting materials …

Music-Based Storytelling For Older Adult Well-Being: An Adapted Multiple Case Study, Zachary Michael Palma

Theses and Dissertations--Music

Autobiographical storytelling can be a meaningful way for older adults to reflect on life experience and support social and emotional well-being. Music has been widely documented as a cue for autobiographical memory. Although the benefits of storytelling and music as a memory cue have been independently examined, limited research has explored its combination with older adults. The purpose of this study was to explore music-based autobiographical storytelling in the lives of older adults. There were three research questions: (1) How do older adults describe their experiences with music-based storytelling? (2) How do they describe the social experience with music-based storytelling? …

Contemporary Commercial Music: A Scoping Review With Implications For Music Therapy Practice, John A. Lawwill

Theses and Dissertations--Music

Contemporary Commercial Music (CCM) is an increasingly popular group of non-classical musical styles. Music therapists need to know how to sing a wide variety of CCM genres authentically, yet little information exists on effectively teaching vocal CCM techniques to music therapists. The purpose of this study was to conduct a scoping review on CCM singing instruction and to synthesize implications for music therapists. I used EBSCOhost and ProQuest to search for reports in English published after 2002 containing the terms “Contemporary Commercial Music” or “CCM,” and variations of the term “sing.” I identified 26 reports that met inclusion criteria, including …

Structuring The Musical Year: Dance, Topic, And Semiosis In Eighteenth-Century Calendar Music, Braden Shaw

Theses and Dissertations--Music

In this thesis, I apply a multifaceted analytical approach to examine a niche category of music called calendar music. In chapter one, I discuss Gregor Joseph Werner’s composition, the New and Very Curious Musical Calendar, and specifically address the minuets found within this work. Werner composes irregular measure groupings in his binary minuets and did so to represent the number of hours in day and night. This irregularity of measure groupings might superficially suggest that Werner’s pieces are stylized minuets only, unintended to accompany physical dancing and far removed from any actual choreographic influence of embodied performance. Werner, …

Belting In Musical Theatre: Vocal Pathologies, Injuries, And Pedagogical Implications, Kaylee Piatt

Theses and Dissertations--Music

Belting has become one of the most defining and contested vocal styles in contemporary musical theatre. Valued for its dramatic immediacy, speech-like intensity, and ability to cut through amplified orchestration, belting is frequently associated with heightened injury risk and pedagogical controversy. This thesis examines the relationship between belting, vocal pathology, and pedagogy through an interdisciplinary lens that integrates voice science, clinical literature, and professional performance practice. Rather than framing belting as an inherently harmful or stylistically aberrant technique, this study conceptualizes belting as a functional vocal coordination shaped by physiological mechanisms, cumulative vocal load, and occupational demands.

Drawing on existing …

Reimagining The Reduction: A Pianist’S Guide To The Piano Reductions Of Korngold’S Violin Concerto And Vaughan Williams’S Tuba Concerto, Zhongyue Zhang

Theses and Dissertations--Music

Piano reductions are an essential medium through which collaborative pianists work with orchestral concertos. However, many existing reductions, particularly of 20th century works, hinder effective performance in terms of orchestral fidelity and feasibility of execution. The problem is twofold: reductions may contain technically cumbersome passages with diminishing musical returns; they may also omit or misrepresent important orchestral effects and textures. For these problematic situations, this work presents pianistic revisions that aim to preserve essential orchestral sound characteristics. Using the first movements of Erich Wolfgang Korngold’s Violin Concerto and Ralph Vaughan Williams’s Tuba Concerto as examples, this work demonstrates a systematic …

Seriosa And The Song Recital Tradition: Reframing The Antologi Musik Klasik Indonesia: Seri I—Vokal Dan Piano (Seriosa), Pharel Silaban

Theses and Dissertations--Music

This project traces the changing life of seriosa, later known as Indonesian art song, from its colonial emergence in the 1930s–1950s to its post-independence expansion and institutional contraction in the 1960s–1980s, and contemporary reframing since the early 2000s. It argues that the genre functioned as a vocal infrastructure that coordinated training, repertoire production, radio broadcast circulation, and public audibility. The study further shows that when the influence of Radio Republik Indonesia weakened, the fragility of this infrastructure became visible. Efforts to sustain the genre by figures such as Rose Pandanwangi, Pranawengrum Katamsi, Catharina Wiriadinata Leimena, and Aning Katamsi appeared …

A Performance Practice Guide To Raleigh Dailey's Sonata For Trumpet And Piano, Kody Jernigan

Theses and Dissertations--Music

Raleigh Dailey is recognized internationally as a jazz pianist, composer, and educator whose compositions span solo works, chamber music, and jazz ensembles. While his music is well known within the jazz community, a significant portion of his catalog remains unknown in the classical performance repertoire. Among these pieces is his Sonata for Trumpet and Piano, a composition that integrates jazz stylistic elements within a classical chamber work.

The purpose of this project is to conduct primary-source research on Dailey’s Sonata for Trumpet and Piano in order to create a comprehensive performance guide for trumpet players. This is accomplished through interviews …

A Conductor's Guide To All-State Orchestra: An Overview Of Repertoire And Best Practices, Nicoletta Moss

Theses and Dissertations--Music

For over one-hundred years, all-state orchestras have served as the premier gatherings of high school musicians across the United States. These short-term events offer intensive ensemble experiences that bring together students from diverse musical and social backgrounds. While conductors play a central role in shaping these experiences, research is limited examining the areas of repertoire programming, pedagogical practices, and other logistical considerations associated with all-state orchestra leadership. In this dissertation, I address these gaps and develop a comprehensive resource for current and future all-state conductors. The present study employs a two-study design: 1) a content analysis of repertoire performed between …

A Method For Beginners Volume 1: The Intersection Of The Yaqui Tribe And Guitar Pedagogy, Daniel Preciado Arreola

Theses and Dissertations--Music

This dissertation is divided into four chapters. The first is an introduction explaining the project; the second describes the Yaqui Tribe's background, significance, and musical traditions, primarily based on three sources: the thesis Sones de Pascola by Cristian Salvador Islas Miranda, the biographical book El Viaje de Mechabili by Daniel Librado Luna, and the album Juya Ánia. The third chapter details the methodological framework and development process used to construct the guitar method presented in Chapter 4. This fourth chapter consists of the first volume of an ongoing multi-volume guitar method—authored by me—focused largely on the melodies from the aforementioned …

Implementations Of Improvisation And Existing Materials In Electroacoustic Composition, Jeffrey Todd-Voyten

Theses and Dissertations--Music

I have developed my compositional process through the use of sound synthesis, existing materials, and improvisation. When combining these techniques and resources, human gestures can emerge from inhuman materials in a dialogue between machines and humans. This thesis is an overview of my initial inquiries into the continuum of human agency and machine intervention, considering aspects of patch-programming, formal structure, and performance practice. In addition to the aforementioned compositional methods, this thesis also considers musico-dramatic meaning and personal musical influences outside the scope of electroacoustic music.

Form As Threshold: The Ontology Of Musical Discourse In Preludio, Fugue And Saturnal, Angel Gomez Ramos

Theses and Dissertations--Music

This study analyzes the formal organization and musical discourse of Preludio, Fugue and Saturnal through a relational and process-oriented framework. It defines form as an emergent condition resulting from the interaction of musical parameters rather than as a predetermined structural model. The analysis focuses on the behavior of pitch organization, rhythmic structure, harmonic stratification, and motivic processes.

The compositional system is examined as a network of differential relations in which musical elements acquire identity through contrast and contextual function. Harmonic and temporal stratification are treated as primary structural mechanisms, alongside the use of non-teleological organization. Motivic material is characterized by …

A Technical And Performance Re-Examination Of Mario Castelnuovo-Tedesco’S Escarramán, Op. 177: Beyond The Angelo Gilardino Publication. A New Performance Edition Of Gallarda, Daniel Monroy Reyes

Theses and Dissertations--Music

This dissertation provides a technical and performance-oriented re-examination of the first four movements of Escarramán: A Suite of Spanish Dances from the XVIth Century (After Cervantes), Op. 177, by Mario Castelnuovo-Tedesco. It argues that the suite embodies a fundamental tension between the composer’s original compositional and structural intentions and the ergonomic limitations of the guitar, and evaluates the proposed solutions by Angelo Gilardino in the 1979 Bèrben edition.

This research employs a comparative, practice-led framework to address the paradox of Castelnuovo-Tedesco’s non-idiomatic writing. Its primary contribution is the development of a performance synthesis that maintains harmonic integrity while enhancing …

Cantate Fratres: Forming And Sustaining Traditional Catholic Music, Liturgy And Culture In The Institute Of Christ The King Sovereign Priest, Reyers P. Brusoe

Theses and Dissertations--Music

The Institute of Christ the King Sovereign Priest is an understudied member of the Traditional Catholic and Latin Mass Communities whose unique approach to Catholic liturgy, culture, and formation offers a sustainable model for the Catholic Church's longevity and renewal. This study is the first of its kind, combining the theoretical positions of affect theory, ecomusicology/musical sustainability, and the musicology of religion to explore and explain the success of this growing classical community. This dissertation examines Church documents, theological literature, and multidisciplinary academic sources as a foundation for the study.             In studying the Institute of Christ the King Sovereign Priest, …

Burnout And Mindful Self-Care Practices Among Bipoc Women Music Therapists: A Cross-Sectional Survey, Melissa V. Peters

Theses and Dissertations--Music

Music therapy as a profession has long acknowledged burnout as a significant occupational concern, yet the experiences of marginalized therapists remain understudied. In particular, little research has explored how burnout and self-care manifest for those who identify as Black, Indigenous, or People of Color (BIPOC) women in a field historically dominated by white women. Most of the existing literature on this topic is focused on the majority identity of music therapists, white women. The purpose of this thesis was to examine the reported levels of burnout among BIPOC women music therapists as well as their reported frequency of engagement in …

Expanding The Canon: A Pedagogical Anthology Of German-Language Musical Theatre Repertoire For The Soprano Voice, Fairynne R. Rogers

Theses and Dissertations--Music

This dissertation proposes the development of the first pedagogically grounded anthology of German‑language musical theatre repertoire curated specifically for the soprano voice, addressing a significant gap in collegiate vocal performance training. Existing anthologies, particularly the Hal Leonard Singer’s Musical Theatre Anthology series, remain dominated by English‑language works, limiting opportunities for singers to build linguistic proficiency, stylistic versatility, and cross‑cultural engagement. German‑language musical theatre, however, represents a sustained vernacular tradition that “prioritizes narrative immediacy and text-driven musical expression distinct from Anglo-American models,” yet it remains largely absent from pedagogical resources. The project assembles twenty‑five selections originally composed in German and excludes …

Embracing Versatility: A Guide To Preparing Undergraduate Saxophonists For The Modern Job Market, James B. O'Donnell

Theses and Dissertations--Music

Instrumentalists who enter their undergraduate degrees in music performance often spend most of their degree focusing on their primary instrument with the hope of finding a career in their chosen discipline. However, a review of current job vacancies (university positions, military bands, and pit orchestras) show that saxophonists are often expected to have ample experience in not only jazz and classical saxophone performance, but also a working knowledge of multiple woodwinds (flute, clarinet, and occasionally double reeds) to be competitive for work. This reality can be daunting for students who enter their undergraduate program with only a basic knowledge of …

Bariatric Surgery Impacts Immune Cell Metabolism And Function Dependent On Metabolic Status, Samantha N. Hart

University of Kentucky Doctoral Dissertations

Type 2 Diabetes (T2D), one of the top ten causes of death worldwide, is fueled by chronic inflammation. T2D is considered a metabolic disease, and there is a great push to target metabolic and associated inflammatory pathways to ameliorate the disease & its comorbidities i.e., obesity and cardiovascular disease. Thus far, clinical trials of anti-inflammatory drugs have had modest impacts on T2D and have not led to changes in clinical practice. This may in part be due to a gap in knowledge in the mechanism(s) driving obesity-associated chronic inflammation. I posit that metabolic abnormalities in immune cells in those with …

Engineering Plga Nanoparticle Size To Modulate Immune Responses After Spinal Cord Injury, Daniel J. Kolpek

University of Kentucky Doctoral Dissertations

Spinal cord injury is a severe and debilitating condition that often results in lifelong complications, including paralysis. Many of these chronic outcomes are driven by a sustained inflammatory response at the injury site, which limits tissue regeneration and functional recovery. As a result, therapeutic strategies that modulate this immune response have gained significant interest. Polymer based nanoparticle therapies have emerged as a promising approach due to their ability to interact with and influence immune cell behavior. Importantly, the physicochemical properties of nanoparticles can be precisely tuned to optimize these effects. Among these properties, size has been shown to influence key …