Digital Commons Network^™

Evaluation Of Guineagrass (Panicum Maximum Jacq) Hybrids In Brazil, Liana Jank, Cacilda B. Do Valle, J. De Carvalho, S. Calixto

IGC Proceedings (1977-2023)

Guineagrass (Panicum maximum Jacq.) is responsible for a high percentage of cattle finishing and milk production in Brazil, but presents problems of pasture degradability due to high soil fertility requirements and uneven production distribution. In order to search for new varieties to reduce these problems, over four hundred apomictic accessions of guineagrass and several sexual plants were introduced to Brazil in 1982. Agronomic evaluation took place at the National Beef Cattle Research Center of the Brazilian Agricultural Research Corporation (Embrapa Beef Cattle), in Campo Grande, MS, Brazil. Breeding of the apomictic species began in 1990 using sexual x apomictic …

Examining Food Security, Choices And Barriers Among Community Supported Agriculture Participants During Covid- 19 In Kentucky, Martha J. Biddle, Junghee Kang, Julie Derringer, Anna Rose, Dawn Brewer, Misook L. Chung, Terry A. Lennie, Gia Mudd-Martin, Timothy A. Woods

UK CARES Faculty Publications

The coronavirus disease (COVID-19) pandemic is challenging food security. Our study’s purpose was to examine relationships among food security status, eating patterns and perceived barriers to food choices among shareholders (N = 209) in a Community Supported Agriculture (CSA) program during stay- at-home restrictions due to the pandemic. The food insecure group (n = 33) reported lower consumption of fruits/vegetables, whole grains and greater consumption of fast foods and more barriers to food choices compared to the food secure group (p < .05). A low food insecure proportion (16%) among the CSA participants suggests a potential role of a CSA program to prevent food insecurity.

Forage News [2021-11], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

No abstract provided.

Interleukin-10 Suppression Enhances T-Cell Antitumor Immunity And Responses To Checkpoint Blockade In Chronic Lymphocytic Leukemia., J R Rivas, Y Liu, S S Alhakeem, J M Eckenrode, F Marti, J P Collard, Y Zhang, K A Shaaban, N Muthusamy, G C Hildebrandt, L Chen, J S Thorson, M Leggas, Subbarao Bondada

Microbiology, Immunology, and Molecular Genetics Faculty Publications

T-cell dysfunction is a hallmark of B-cell Chronic Lymphocytic Leukemia (CLL), where CLL cells downregulate T-cell responses through regulatory molecules including programmed death ligand-1 (PD-L1) and Interleukin-10 (IL-10). Immune checkpoint blockade (ICB) aims to restore T-cell function by preventing the ligation of inhibitory receptors like PD-1. However, most CLL patients do not respond well to this therapy. Thus, we investigated whether IL-10 suppression could enhance antitumor T-cell activity and responses to ICB. Since CLL IL-10 expression depends on Sp1, we utilized a novel, better tolerated analogue of the Sp1 inhibitor mithramycin (MTM

A Review Of Kentucky’S Extended-Weight Hauling Programs, P. Gayle Marks, Jon Wilcoxson, Bryan Gibson, Chris Van Dyke, Andrew Martin, Jennifer Walton, Doug Kreis

Kentucky Transportation Center Research Report

Kentucky established its Extended Weight Coal or Coal By-products Haul Road System (EWCHRS) to increase the state’s competitiveness within the coal industry and reduce financial burdens on coal haulers. A new extended-weight haul system for unrefined petroleum products will come online in 2022. To facilitate enforcement of weight limits throughout Kentucky, this report surveys literature on how overweight vehicles affect roads and bridges, describes statutes and regulations governing weight limits in the state, discusses policies and strategies used throughout the US to handle overweight vehicles, and makes recommendations for improving extended-weight policies in Kentucky. It is apparent that pavements and …

Assessment Of Deteriorated Structural Concrete To Provide Durable Repairs, Theodore Hopwood, Christopher Goff, Sudhir Palle

Kentucky Transportation Center Research Report

Most of the structural elements on Kentucky bridges are made of reinforced concrete. Many of these elements deteriorate as a result of corrosion of the reinforcing steel caused by carbonation and — primarily — applications of chlorides by the Kentucky Transportation Cabinet (KYTC). Corrosion of reinforcing steel is reviewed along with assessment procedures that leverage nondestructive evaluation (NDE) methods and related laboratory and field tests. Several maintenance procedures are discussed, including the application of sealers and coatings, patch and major concrete repairs, and electrochemical methods. Incorporating NDE and test results into maintenance procedure selection is discussed. Recommendations are provided on …

Design Mythbusters, Christopher Van Dyke, Steve Waddle, Doug Kreis

Kentucky Transportation Center Research Report

When highway project designs depart from design values found in the Kentucky Transportation Cabinet (KYTC) Highway Design Manual and AASHTO’s A Policy on Geometric Design of Highways and Streets, project managers at the agency must obtain either a design exception or design variance. While designers are more comfortable with exceptions and variances than they were 10 or 20 years ago, some hesitancy remains, especially among the Cabinet’s consultants. Misperceptions about what exceptions or variances entail or about their performance may underlie this reluctance. Exceptions and variances are best conceptualized as formal justifications for design decisions. Project managers merely need …

Development Of A Novel Mir-3648-Related Gene Signature As A Prognostic Biomarker In Esophageal Adenocarcinoma, Donglei Zhang, Hang Yin, Thomas L. Bauer, Michael P. Rogers, Jeffrey B. Velotta, Clinton T. Morgan, Weijia Du, Ping Xu, Xiaozhe Qian

Surgery Faculty Publications

Background: Esophageal adenocarcinoma (EA) is a typical immunogenic malignant tumor with a dismal 5-year survival rate lower than 20%. Although miRNA-3648 (miR-3648) is expressed abnormally in EA, its impact on the tumor immune microenvironment remains unknown. In this study, we sought to identify immune-related genes (IRGs) that are targeted by miR-3648 and develop an EA multigene signature.

Methods: The gene expression data of 87 EA tumor samples and 67 normal tissue samples from The Cancer Genome Atlas (TCGA) database and the Genotype-Tissue Expression (GTEx) database were downloaded, respectively. Weighted gene co-expression network analysis (WGCNA), the CIBERSORT algorithm, and Cox regression …

Prediction Of Dry Matter Intake Based On Ruminal Degradation From Milking Cows Grazing Coast-Cross Grass, T. T. Berchielli, J. P. G. Soares, L. J. M. Aroeira, C. L. Furlan, A. K. D. Salman, R. N. Da Silveira, E. B. Malheiros

IGC Proceedings (1977-2023)

Dry matter intake (DMI) of coast-cross grazing by crossbred Holstein-Zebu and Zebu lactating cows was calculated using in vitro dry matter digestibility from extrusa (four esophageal fistulated cows) and fecal output estimate with mordent chromium. Pasture was rotationally grazed with three days grazing period and 27 days resting period, adopting a stocking rate of 1.6 and 3.2 cows/ha, during the dry and rainy season respectively. Voluntary DMI was estimated from degradation characteristics using different equations. Predicted coast-cross DMI varied with models. The prediction of tropical forages dry matter intake from equations based in ruminal degradation parameters needs further investigation before …

Forage Quality, Yield And Palatability Of Quackgrass (Elytrigia Repens (L.) Nevski), T. Yagi, R. Meguro, E. Fukuda

IGC Proceedings (1977-2023)

Quackgrass (Elytrigia repens (L.) Nevski) is a competitive perennial invader of pastures and hay meadows which is frequently harvested as forage in mixtures with desired forage species. Field experiments were conducted to compare quackgrass with cool-season perennial grasses grown under the same soil and climatic conditions, in terms of forage quality, productivity, and palatability. The forage quality of the hays was influenced by the grass species. Quackgrass showed forage crude protein (CP) concentration that was equal to those of perennial ryegrass (Lolium perenne), reed canarygrass (Phalaris arundinacea) and Kentucky bluegrass (Poa pratensis), and …

In Vitro Gas Production Technique To Predict Dmd Of Ensiled Forage Ruminant Based Diets, M. Wawrzkiewicz, J. L. Danelón, G. Jaurena

IGC Proceedings (1977-2023)

The in vitro gas production technique was used as a tool to develop an improved prediction model of dry matter digestibility of ensiled forage based diets. Eleven diets were tested through conventional experiments of in vivo dry matter digestibility (DMD). The same diets were evaluated by the in vitro gas production technique using a gas pressure transducer . The parameters of the model y = A - B Q^t Z^√t were calculated with data from the accumulated gas curves, i.e. y=cumulative gas production (ml), Q=e^-b, Z=e^-c, B=e^bT+c√T , being …

Amaranth Productivity And Nutrient Composition In Central Georgia, W. F. Whitehead, Thomas H. Terrill, B. P. Singh, S. Gelaye

IGC Proceedings (1977-2023)

Amaranth (Amaranthus spp.) may have potential as a forage for summer grazing in the southeastern United States (US). Six accessions of amaranth were harvested at bud stage in two successive growing seasons to evaluate growth characteristics, yield, and forage quality parameters. The accessions, three genotypes of A. tricolor (Hinchoy VL, RRC-701, RRC-1186) and one each of A. hybridus (RRC-843), A. cruentus (RRC-1034), and A. dubius (RRC-1186) were evaluated in 1994 and 1995 on a Dothan sandy loam (fine loamy, siliceous, thermic, Plinthic Paleudult) soil at the Fort Valley State University Research Station, Fort Valley, Georgia. The plots were planted …

Supplementation With Brosimum Alicastrum Swartz To Pelibuey Sheep Fed Low Quality Rations, Luis Ramírez-Avilés, V. Valdivia-Salgado, Juan C. Ku-Vera

IGC Proceedings (1977-2023)

The objective of the present study was to assess the influence of supplementing increasing levels of ramón (Brosimum alicastrum) foliage to Pelibuey sheep fed guinea grass (Panicum maximum) hay. Rate and extent of rumen degradation of organic matter (OM) and crude protein (CP) of ramón foliage were high. Dry matter (DM) intake of the diet was increased by the inclusion of ramón foliage. However, rate and extent of digestion of guinea grass was not affected by the ramón foliage. Rate of passage of solid was linearly increased as a result of the inclusion of ramón foliage …

Euglycemic Diabetic Ketoacidosis Due To Sglt2 Inhibitor In A Patient With Gitelman Syndrome: A Therapeutic Dilemma, Taha Ahmed, Hussain Karimi, Vishwajit Hegde, Samra Haroon Lodhi

Internal Medicine Faculty Publications

Euglycemic diabetic ketoacidosis (DKA) is a rarely reported side effect of sodium-glucose cotransporter-2 inhibitor (SGLT2i) empagliflozin. A 51-year-old female with Gitelman syndrome and type 2 diabetes mellitus (DM) presented with abdominal pain after a recent hospitalization for acute pancreatitis. Her diabetes medications included metformin, pioglitazone, and empagliflozin. Diabetic ketoacidosis was suspected; however, glucose levels were below the cutoff for DKA; therefore, she was diagnosed with euglycemic DKA. Her pancreatitis workup was insignificant. Severe symptomatic hypokalemia despite aggressive repletion limited the management of DKA with insulin infusion therapy. As her ketonemia resolved, she was initiated on subcutaneous insulin with a small …

Effect Of Water-Soluble Browning Products In Heated Herbages On Rumen Microorganisms, E. Touno, A. Takenaka, T. Kondo, O. Tanaka, M. Murai

IGC Proceedings (1977-2023)

When feed is heated, browning can occur. This browning is detrimental to both the value of feed and physiological functioning of the animal. Browning occurs when polymeric substances are produced during the Maillard reaction. Indigestible soluble Maillard reaction products could affect nitrogen utilization by ruminants. A method has been established for isolation of water-soluble browning products using a reversed phase column. In the present work, the effect of water-soluble browning products isolated from heated herbage on rumen microorganisms was investigated. A solution of browning products was added to the medium 10 to obtain final concentration of 0, 0.5 and 2.0 …

Comparison Of Summer Forages And The Effect Of Nitrogen Fertilizers On Brassica Forages In Tasmania, A. A. Salardini, R. J. Eckard, D. R. Franks

IGC Proceedings (1977-2023)

Summer forage crops, and in particular Brassica spp., have become increasingly popular in dairy production systems in Tasmania. Field experiments were conducted for 3 years in northwestern Tasmania, in the spring/summers beginning in 1995. The study aimed to compare yield and quality of Brassica and Poaceae forages and the response of Brassica species to nitrogen (N) (50, 100 and 200 kg N/ha) and irrigation.

The average total yields of dryland (rainfed) crops in 1995 to 1997 experiments, were turnip (Brassica rapa) 9.3 t/ha, rape (B. napus) 5.9 t/ha, oats (Aevena sativa) 5.2 t/ha, kale …

Maturity And Fertilization Effects On Leaf Blade Tissue Percentages Of Contrasting Fescue Cultivars, L. B. Tempone, M. S. Cid, M. A. Brizuela, M. C. Nunciari, M. G. Cendoya

IGC Proceedings (1977-2023)

Palenque Plus and Ceres Torpedo are tall fescue (Festuca arundinacea Schreb.) cultivars available to the animal production systems in the humid Pampean Region of Argentina. They differ in growth cycle and morphological characteristics. At vegetative stage, Torpedo leaves are fine and tender, which suggests that their percentages of slowly digestible and indigestible tissues (SDIT) should be low. In this study we 1) explored the effects of phenological stage and nitrogen fertilization on leaf blade tissue percentages of both cultivars, using an ordination multivariate technique, and 2) evaluated the effects of these factors on the percentage of SDIT. Our results …

Different Harvest Schedules To Prepare Deferred Forage From C4 Grasses In Córdoba, Argentina, M. R. Steinberg, E. F. Nienstedt, H. A. Valdez, J. C. Coraglio, C. A. Vieyra, P. A. Minuzzi

IGC Proceedings (1977-2023)

From 1995 until 1999 a trial was done in the fields of the Universidad Nacional de Córdoba with four C4 forage grasses. These fields lie in the subtropical and semiarid region of Argentina. This research aimed to identify forage species that could be used as deferred forage for the drier and cooler winter season. Four species of C4 grasses were used: Rhodesgrass (Chloris gayana Kunth), Gatton (Panicum maximum), coloratum (Panicum coloratum) and digitgrass (Digitaria eriantha), respectively. Two growing periods were used: full season growth (FS) and half season regrowth (HS), in both cases …

Boron Fertilization Effects On Nutritive Parameters Of Alfalfa, F. M. Rouquette Jr., V. A. Haby, J. O. Fritz, M. Collins

IGC Proceedings (1977-2023)

With early pre-plant incorporation of limestone to raise soil pH to 6.8 to 7.0, alfalfa (Medicago sativa L.) may be grown successfully on acid, Coastal Plain, sandy loam soils. Fertility and forage quality for hay and/or grazing require alternative management of alfalfa on these Coastal Plain soils. A two-year experiment evaluated alfalfa fertilized with three rates of boron to quantify effects on nutritive entities, especially fiber components. On a whole-plant basis in year 1, only crude protein was increased (P < .05) at one of six harvest dates. In year 2, chemical analyses of leaf-stem components indicated consistent increases in crude protein of leaf fractions at each harvest (P < .05), reduction in neutral detergent fiber at three harvest dates (P < .06), and reduced lignin (P < .07) at the final harvest. Stem sections were affected by rate of boron at only the June harvest with an increase in crude protein (P < .05). Rate of boron fertilization had indirect effects on nutritive value (crude protein) by either delaying physiological maturity or enhancing nitrogen fixation in leaves, and had a direct negative effect on certain fiber components.

The Role Of Grass Feeding In Improving Oxidative Stability And Increasing Vitamin B12 Content Of Beef And Veal, V. Pastushenko, H.-D. Matthes, H. Heinrich, Z. Holzer, T. Prokopyuk

IGC Proceedings (1977-2023)

The objective of this study was to investigate the influence of grass feeding of cattle on the decontamination capacity against free radical (DCAFR) and vitamin B₁₂ content of beef and veal. The meat samples from intensively (26 cattle, final weight 485±9 kg, concentrate feeding) and ecologically (25 heifers, final weight 472±32 kg, and 28 calves, final weight 260±24 kg, pasture grazing) managed cattle groups were investigated. The DCAFR was colorimetric assessed by examining damage to 1.4 benzoquinone. Vitamin B₁₂ was analyzed by high performance liquid chromatography. Data indicate that the oxidative stability of meat samples from ecological management …

Nitrate Accumulation In A Sorghum-Sudangrass Hybrid As Influenced By Nitrogen Fertilization, A. Elgersma, I. Y. Tecle, T. Provin

IGC Proceedings (1977-2023)

The effect of nitrogen (N) fertilization and plant stage on nitrate accumulation was studied in a sorghum-Sudan grass hybrid. Grass cv. Dynagrazer was sown at the experimental site of Texas A & M University. Six N levels were applied (0, 112 … 672 Kg. N ha^-1). Nitrate concentrations were determined in three harvests, 5– 7 weeks after planting. Maximum levels were 2.1, 3.5 and 4.6 g nitrate-N kg^-1 DM, respectively, which is beyond the safe limits for animal consumption. The plots were cut at heading. Regrowth took place on residual N. Nitrate-N accumulation was lowest in the …

Effect Of Maceration On In Sacco Degradability And Energy Content Of Low-Moisture Round Bale Alfalfa Silage, K. Nonaka, S. Kume, T. Ohshita

IGC Proceedings (1977-2023)

The aim of this study was to determine the effect of maceration on in sacco degradability and energy content of low-moisture alfalfa (Medicago sativa L.) silage. The results of two treatments were compared: 1) maceration, in which the alfalfa was processed through a large- scale forage mat maker prior to wilting to approximately 50% DM content (FM treatment), and 2) conventional conditioning, in which the alfalfa was tedded and wilted to the same DM content as that in the FM treatment (CC treatment). Silage bales were chopped in 20-mm pieces for each experiment. In sacco degradabilities of DM, CP …

Efficiency Of Nitrogen Use In Dairy Cows Grazing Ryegrass With Different Water Soluble Carbohydrate Concentrations, L. A. Miller, D. H. Baker, M. K. Theodorou, J. C. Macrae, M. O. Humphreys, Nigel D. Scollan, J. M. Moorby

IGC Proceedings (1977-2023)

This experiment is one of a series designed to investigate the efficiency of nitrogen (N) use in Holstein-Friesian dairy cows grazing perennial ryegrass (Lolium perenne) which has been bred to express high water soluble carbohydrate (WSC) concentrations. Animals grazed either a High Sugar (HS) grass or a Control (C) variety chosen on the basis of heading date compatibility. Dry matter (DM) intakes were estimated using herbage mass. Milk yields, milk constituent concentrations and plasma concentrations of b-hydroxybutyrate, glucose, total protein, albumin and urea were also measured. Forage DM intakes were similar for the two grasses. However, because of …

Maris: Scalable Online Scenario Development Tool For Rangeland Conservancy Managers Using High Spatial-Temporal Resolution Carrying Capacity Maps And Livestock Market Data, L. G. J. Boerboom, R. O. Ohuru, A. G. Toxopeus, W. Nieuwenhuis, C. A. J. M. De Bie, P. K. Mwangi, M. L. Schouwenburg, R. L. G. Lemmens

IGC Proceedings (1977-2023)

Although the management of livestock numbers within the bounds of carrying capacity of African rangelands is a way to manage risks, both scientists and practitioners, caution against a momentary and local use of carrying capacity as a management indicator. Carrying capacity should be seen in wider spatial and temporal/seasonal context as well as in a social and economic context. Given the large numbers of conservancies across Kenya, and its Maasai Mara region in particular, with many more landowner members, it is difficult for conservancies’ managers to contextualize phenomena such as carrying capacity and market price over space and time.

We …

Assessing The Impacts Of Different Initiatives On The Rehabilitation Of Pastoral And Silvopastoral Ecosystems: Big Data Oriented Approach, Said Moukrim, Said Lahssini, Mustapha Naggar, K. Menzou, H. Mharzi-Alaoui, A. Labbaci, L. Rhazi

IGC Proceedings (1977-2023)

Moroccan forests, through the provision of goods and ecosystem services, underpins benefits to local communities and play a crucial role for rural area development. The legal framework recognizes to people, living near public forests, the right to graze their domestic livestock. Over the years, the grazing pressure is at levels far beyond the forestland’s carrying capacity throughout the country. Such pressure has been demonstrated as the main cause of forest cover loss and land degradation in Morocco and still threatening the sustainability of forests. To reduce the heavy grazing pressure on forest ecosystems and ensure their regeneration, several initiatives have …

The Role Of Indigenous Knowledge In The Effective Collective Management Of The Communal Rangelands, A. Finca, S. Linnane, D. Getty, J. H. Slinger

IGC Proceedings (1977-2023)

Numerous scientific studies have highlighted the complexities associated with the collective management of communal rangelands. To date, policy interventions in rangelands have largely ignored people’s traditional ways of managing, with adverse effects on rangeland productivity. Thus, local knowledge has not been considered in spatial planning, despite the fact that local rural communities are often repositories of key indigenous knowledge. Hence this study set out to evaluate the role of indigenous knowledge in the management of the communal rangeland in Cata and Guquka, now and in the future. This was achieved through the use of Participatory GIS (PGIS), specifically participatory mapping …

Land Users – Land Watchers, J. H. Stefánsson, B. Marteinsdóttir

IGC Proceedings (1977-2023)

GróLind is a collaborative project with the aim of monitoring Icelandic vegetation and soil resources. It was founded in 2017 by the Icelandic National Associations of Sheep Farmers, the Farmers Association of Iceland, Ministry of Industries and Innovation, and the Soil Conservation Service of Iceland. GróLind is a collaborative project and cooperation with stakeholders, such as the science community, landowners, and others, is a fundamental concept in the project.

In this project, the state of vegetation and soils are evaluated. Currently, a citizen science project is being developed within GróLind, in which land-users will annually monitor, using a mobile app, …

Silvopastoral Strategy And Sustainable Management Of Forests In Morocco, Mustapha Naggar, Said Lahssini, Said Moukrim, Anass Legdou

IGC Proceedings (1977-2023)

In Morocco, forests act as a grazing reserve all year long and in a normal year produce 1.5 billion feed units, i.e. 17 % of the national forage assessment. The pastoral question is one of the factors involved in the desertification of forested areas against a bioclimatic background where more than 93% of the national territory is arid. In 2016, the Water and Forestry Department in cooperation with its partners, devised a nation-wide sylvo-pastoral strategy. The approach adopted consists in sustainably managing sylvo-pastoral resources over the long term based on good governance of all goods and services offered by forested …

Untargeted Lipidomics Of Non-Small Cell Lung Carcinoma Demonstrates Differentially Abundant Lipid Classes In Cancer Vs. Non-Cancer Tissue, Joshua M. Mitchell, Robert M. Flight, Hunter N. B. Moseley

Molecular and Cellular Biochemistry Faculty Publications

Lung cancer remains the leading cause of cancer death worldwide and non-small cell lung carcinoma (NSCLC) represents 85% of newly diagnosed lung cancers. In this study, we utilized our untargeted assignment tool Small Molecule Isotope Resolved Formula Enumerator (SMIRFE) and ultra-high-resolution Fourier transform mass spectrometry to examine lipid profile differences between paired cancerous and non-cancerous lung tissue samples from 86 patients with suspected stage I or IIA primary NSCLC. Correlation and co-occurrence analysis revealed significant lipid profile differences between cancer and non-cancer samples. Further analysis of machine-learned lipid categories for the differentially abundant molecular formulas identified a high abundance sterol, …

Androgen Receptor Signaling In Prostate Cancer And Therapeutic Strategies, Aasems Jacob, Rishi Raj, Derek B. Allison, Zin W. Myint

Markey Cancer Center Faculty Publications

Understanding of the molecular mechanisms of prostate cancer has led to development of therapeutic strategies targeting androgen receptor (AR). These androgen-receptor signaling inhibitors (ARSI) include androgen synthesis inhibitor-abiraterone and androgen receptor antagonists-enzalutamide, apalutamide, and darolutamide. Although these medications provide significant improvement in survival among men with prostate cancer, drug resistance develops in nearly all patients with time. This could be through androgen-dependent or androgen-independent mechanisms. Even weaker signals and non-canonical steroid ligands can activate AR in the presence of truncated AR-splice variants, AR overexpression, or activating mutations in AR. AR splice variant, AR-V7 is the most studied among these and …