Digital Commons Network^™

The Role Of Class Xi Myosin In Fertilization Of Arabidopsis Thaliana, Umma Fatema

Theses and Dissertations--Plant and Soil Sciences

Fertilization is the process of fusion of haploid male and female gametes to develop a new individual. In most animals, microtubules drive the migration of the female pronucleus toward the male pronucleus for fertilization. By contrast, the fertilization process in flowering plants is dependent on actin filament (F-actin) dynamics; F-actin, not microtubules, is responsible for sperm nuclear migration. In one of the female gamete cells, the central cell, constant F-actin meshwork inward movement towards the nucleus takes place to transfer the sperm nucleus for karyogamy. This inward F-actin dynamic is controlled by a unique ARP2/3 (Actin Related Protein 2/3)-independent WAVE/SCAR …

Blocking The Acquisition Of Ethanol-Induced Conditioned Place Preference With 11, 21-Bisphenyl-19-Norpregnane (Pt150) In Coturnix Quail, Mia Radevski

Theses and Dissertations--Psychology

Alcohol use disorder (AUD) has been associated with a dysregulated stress system. Therefore, regulating stress hormones has been investigated as a potential therapeutic target for AUDs. The purpose of the current study was to investigate whether a stress hormone receptor antagonist, PT150, would block the rewarding properties of ethanol. Quail were used as subjects because a conditioned place preference (CPP) apparatus that utilized visual cues was used, and quail readily attend to visual cues. Visual cues in the environment have been shown to become associated with alcohol effects and later induce craving. Starting on day one, quail were pretreated with …

The Role Of Affective Heterogeneity On Treatment Effects For Youth With Conduct Problems, Pevitr Singh Bansal

Theses and Dissertations--Psychology

Conduct problems (CP) are a class of disruptive and aggressive behaviors (e.g., aggression, vandalism) comprised of both oppositional defiant and conduct disorder. CP are highly heterogenous and one vital factor that parses out this heterogeneity is affect, specifically the affective traits of irritability (IRR) and limited prosocial emotions (LPE). The current study examined how IRR and LPE predict distinct aspects of treatment efficacy including (1) treatment response (i.e., magnitude of change from week 1 to week 5); (2) trajectories (i.e., shape of symptom change); and (3) time-out (i.e., behavioral and emotional reactions to time-out). Participants were 49 youth aged 7-12 …

Examining The Indirect Effect Of Trauma On Obsessive-Compulsive Symptoms Through Responsibility/Threat Beliefs, Emily E. Fenlon

Theses and Dissertations--Psychology

Inflated responsibility beliefs and threat estimations have been implicated in the etiology and maintenance of obsessive-compulsive (OC) symptoms. Research suggests that early life experiences that involve actual or perceived serious harm to oneself or others may lead to inflated responsibility/threat beliefs and OC symptoms. Research has yet to explore if traumatic experiences influence responsibility/threat beliefs or if the associations between trauma and OC symptoms are at all dependent on trauma’s influence on responsibility/threat beliefs. The present study aims to examine associations among exposure to potentially traumatic events (PTEs), responsibility/threat beliefs, and OC symptoms. A sample of 886 undergraduate students completed …

Investigating Mechanisms Of Injury And Intervention In A Novel In Vitro Model Of Traumatic Brain Injury In Organotypic Hippocampal Slice Cultures, Julia Elaine Jagielo-Miller

Theses and Dissertations--Psychology

Traumatic brain injuries (TBIs) impact millions of individuals each year and can pose long term consequences. Despite numerous attempts, no medication has been approved by the FDA to treat TBIs. The causes of these failed trials are multifaceted, but in part can be attributed to the complex nature of TBIs, as well as a lack of sufficient pre-clinical data. In vitro models of TBI are an important tool to help understand the cellular changes seen following the injury, in a highly controlled environment. For the following experiments, a novel model of TBI was used to injure organotypic hippocampal slice cultures, …

Pain Interference Across Chronic Pain Populations: Variability And Associated Psychosocial Processes, Stephanie Judge

Theses and Dissertations--Psychology

Chronic pain is one of the most common health complaints, yet the limited effectiveness of existing treatment options suggests that chronic pain is still not fully understood. The goals of this study are to identify and organize well-established and emerging psychosocial factors associated with pain interference, clarify the nature of between- and within-diagnostic group differences in psychosocial and demographic factors associated with pain interference, and identify interactions among diagnostic and psychosocial factors associated with pain interference.

Community-dwelling participants (N = 284) completed a one-time survey which included demographic information, information about pain and diagnosis, and five existing measures that assess …

Effects Of Snake Fungal Disease On The Survival And Growth Of The Queensnake (Regina Septemvittata), Andrew Jerome Ibach

Theses and Dissertations--Forestry and Natural Resources

Having only emerged as a threat to snakes in 2006, relatively little is known of snake fungal disease’s (SFD) impacts on demographic processes, particularly survival and growth. I used data from an extensive capture-mark-recapture study to examine survival and growth in central Kentucky Queensnake (Regina septemivittata) populations. I found that diseased snakes and healthy snakes possessed similar monthly survival estimates (SFD positive 0.9687, 95% CI 0.8444 to 0.9944; SFD negative 0.8735, 95% CI 0.7518 to 0.9402) and that disease state transition probability from SFD negative to SFD positive, and SFD positive to SFD negative were also similar (N-P …

Nondestructive Multivariate Classification Of Codling Moth Infested Apples Using Machine Learning And Sensor Fusion, Nader Ekramirad

Theses and Dissertations--Biosystems and Agricultural Engineering

Apple is the number one on the list of the most consumed fruits in the United States. The increasing market demand for high quality apples and the need for fast, and effective quality evaluation techniques have prompted research into the development of nondestructive evaluation methods. Codling moth (CM), Cydia pomonella L. (Lepidoptera: Tortricidae), is the most devastating pest of apples. Therefore, this dissertation is focused on the development of nondestructive methods for the detection and classification of CM-infested apples. The objective one in this study was aimed to identify and characterize the source of detectable vibro-acoustic signals coming from CM-infested …

Using Stream Restoration To Mitigate Stormwater Runoff In An Urban Watershed: A Case Study, Jonathan M. Brantley

Theses and Dissertations--Biosystems and Agricultural Engineering

The goal of this case study was to evaluate the effectiveness a 275 m regenerative stream restoration design to mitigate stormwater runoff in a highly urbanized watershed. The restoration resulted in a wide, wetland-like floodplain, comprised of a rock base that was overtopped with a filtration media (approximately 30% woodchips and 70% topsoil). The creation of the floodplain-wetland complex in tandem with filtration media lead to increased storage capacity and an increase in hyporheic exchange within the system. Significant reductions were found for the storm hydrograph parameters volume, peak discharge, and time to peak. Reductions in baseflows were also noted …

Improving Network Policy Enforcement Using Natural Language Processing And Programmable Networks, Pinyi Shi

Theses and Dissertations--Computer Science

Computer networks are becoming more complex and challenging to operate, manage, and protect. As a result, Network policies that define how network operators should manage the network are becoming more complex and nuanced. Unfortunately, network policies are often an undervalued part of network design, leaving network operators to guess at the intent of policies that are written and fill in the gaps where policies don’t exist. Organizations typically designate Policy Committees to write down the network policies in the policy documents using high-level natural languages. The policy documents describe both the acceptable and unacceptable uses of the network. Network operators …

Design, Development And Benchmarking Of Machine Learning Algorithms In Biomedical Applications, Qi Sun

Theses and Dissertations--Computer Science

Machine learning algorithms are becoming the most effective methods for knowledge discovery from high dimensional datasets. Machine learning seeks to construct predictive models through the analysis of large-scale heterogeneous data. While machine learning has been widely used in many domains including computer vision, natural language processing, product recommendation, its application in biomedical science for clinical diagnosis and treatment is only emerging. However, the wealthy amount of data in the biomedical domain offers not only challenges but also opportunities for machine learning. In this dissertation, we focus on three biomedical applications from vastly different domains to understand the opportunities and challenges …

Supporting Stylized Language Models Using Multi-Modality Features, Chengxi Li

Theses and Dissertations--Computer Science

As AI and machine learning systems become more common in our everyday lives, there is an increased desire to construct systems that are able to seamlessly interact and communicate with humans. This typically means creating systems that are able to communicate with humans via natural language. Given the variance of natural language, this can be a very challenging task. In this thesis, I explored the topic of humanlike language generation in the context of stylized language generation. Stylized language generation involves producing some text that exhibits a specific, desired style. In this dissertation, I specifically explored the use of multi-modality …

Protocols And Architecture For Privacy-Preserving Authentication And Secure Message Dissemination In Vehicular Ad Hoc Networks, Shafika Showkat Moni

Theses and Dissertations--Computer Science

The rapid development in the automotive industry and wireless communication technologies have enhanced the popularity of Vehicular ad hoc networks (VANETs). Today, the automobile industry is developing sophisticated sensors that can provide a wide range of assistive features, including accident avoidance, automatic lane tracking, semi-autonomous driving, suggested lane changes, and more. VANETs can provide drivers a safer and more comfortable driving experience, as well as many other useful services by leveraging such technological advancements. Even though this networking technology enables smart and autonomous driving, it also introduces a plethora of attack vectors. However, the main issues to be sorted out …

Smart Decision-Making Via Edge Intelligence For Smart Cities, Nathaniel Hudson

Theses and Dissertations--Computer Science

Smart cities are an ambitious vision for future urban environments. The ultimate aim of smart cities is to use modern technology to optimize city resources and operations while improving overall quality-of-life of its citizens. Realizing this ambitious vision will require embracing advancements in information communication technology, data analysis, and other technologies. Because smart cities naturally produce vast amounts of data, recent artificial intelligence (AI) techniques are of interest due to their ability to transform raw data into insightful knowledge to inform decisions (e.g., using live road traffic data to control traffic lights based on current traffic conditions). However, training and …

Matrix Interpretations And Tools For Investigating Even Functionals, Benjamin Stringer

Theses and Dissertations--Computer Science

Even functionals are a set of polynomials evaluated on the terms of hollow symmetric matrices. Their properties lend themselves to applications such as counting subgraph embeddings in generic (weighted or unweighted) host graphs and computing moments of binary quadratic forms, which occur in combinatorial optimization. This research focuses primarily on counting subgraph embeddings, which is traditionally accomplished with brute-force algorithms or algorithms curated for special types of graphs. Even functionals provide a method for counting subgraphs algebraically in time proportional to matrix multiplication and is not restricted to particular graph types. Counting subgraph embeddings can be accomplished by evaluating a …

Image Geo-Localization With Cross-Attention, Connor Greenwell

Theses and Dissertations--Computer Science

The problem of estimating the location from which un-geotagged photographs were captured has been well studied by the computer vision community in recent years. The central proposal of this thesis is to define a common framework within which existing approaches can be constructed and evaluated, and to introduce a new method under this framework which uses cross-attention between the query image and a database of satellite imagery with known geotags. Our experiments fit within three broad categories: 1) evaluating the ability of image localization approaches to generalize to unseen regions; 2) examining performance changes under various reference database resolutions, scales, …

An Automated Framework To Debug System-Level Concurrency Failures, Tarannum Shaila Zaman

Theses and Dissertations--Computer Science

The ever-increasing parallelism in computer systems has made software more prone to concurrency failures, causing problems during both pre- and post-development. Debugging concurrent programs is difficult because of the non-deterministic behavior and the specific sequences of interleaving in the execution flow. Debugging is a technique where programmers reproduce the bug, identify the root cause, and then take necessary steps to remove the bug from the system. The failure information may come from the bug reports of the testing phase or the production runs. In both cases, there should be steps taken to reproduce and localize the failure. However, reproducing and …

We Can Still Feed Ourselves: Food Sovereignty, Aid, Sickness, And Health In Eastern Kentucky, Annie Koempel

Theses and Dissertations--Anthropology

Over forty percent of eastern Kentucky residents are classified as obese. From a biomedical perspective, obesity is linked to a range of chronic diseases, including heart disease, diabetes, and high blood pressure and is caused by particular lifestyle behaviors that lead to an increase in calorie consumption and decrease in calorie expenditure. However, these links – individual behavior leads to obesity which leads to chronic disease - do not take into account a wide range of personal, social, environmental, political, and economic conditions. In addition to the assumptions of what it means to become and be obese, Kentucky is regularly …

Development With Identity Or Commodities With Identity? Lenca Craftswomen, Honduras' Cultural Identity Politics, And Global Economies Of Culture, Ana Hasemann Lara

Theses and Dissertations--Anthropology

Across Latin America ‘development with identity’ schemes are currently widely promoted by multilateral and aid organizations; schemes based on the commercialization of heritage, which increasingly focus on impoverished ethnic minorities. As part of this trend, the Honduran state’s discourse on cultural diversity reinforces the ‘heritage-making’ (patrimonialización) of cultural minorities, their identities, and livelihoods—particularly indígena women, under the auspices of multiculturalism. However, the on-the-ground reality for indigenous Lenca communities, specifically Lenca craftswomen, participating in such initiatives, remains with some of the highest indices of poverty and vulnerability in the country. Hence, the conditions under which ‘development with identity’ benefits local communities, …

An Investigation Of Hhv6'S Impact On The Cognitive Progression And Microglial Changes In An Alzheimer's Disease Cohort, Charles E. Seaks

Theses and Dissertations--Physiology

The role of herpesviruses and, more specifically, HHV6 in the development of Alzheimer’s disease (AD) and associated cognitive decline is still being investigated. High ubiquity and prevalence in the population have led to a high degree of skepticism about HHV6 as a potential contributor to cognitive decline and dementias. However, recent evidence related to another herpesvirus, herpes simplex virus 1, suggests that reactivation, not carriage, of the virus may be the key factor to explain the dissonance between the virus’ ubiquity and contributions to dementias. With that in mind, we set out to assess cases from the Sanders-Brown Center on …

Wrfl 88.1fm Strategic Plan, Clayton Abernathy

MPA/MPP/MPFM Capstone Projects

WRFL 88.1 FM (WRFL) is a student-run radio station at the University of Kentucky that has existed on the University of Kentucky’s campus since 1988. As the station recently turned 34 years old in March 2022, it has never had a strategic plan or gone through the strategic planning process. The strategic planning process was facilitated by the Principal Investigator and involved members of WRFL’s leadership team, and general student and community members. Using multiple data collection methods to gather feedback, the Principal Investigator was able to present WRFL’s leadership team with a plan that they believe will provide WRFL …

The Impact Of Korean Government’S Industrial R&D Expenditure On Technological Competitiveness, Hyunok Kim

MPA/MPP/MPFM Capstone Projects

In Korea, the total amount of R&D executed by the Korean government in 2019 was $16 billion. The Compound Annual Growth Rate of Korean government R&D budget is 5.04% (2010~2019). This paper studies whether the Korean government's R&D expenditure effectively achieves its purpose. Assuming the purpose of government R&D expenditure is set as science and technology competitiveness based on related laws and the indicator is identified as the technology balance of payments (TBP), this study estimates the statistical correlation between government R&D expenditure and TBP. Since the characteristic of government R&D expenditure is different for each field, the correlation by …

Comparative Demographic And Geographic Analysis Of Civic Participation In Lexington, Kentucky, Grant Long

MPA/MPP/MPFM Capstone Projects

What are the underlying motivations which may have an effect on voter turnout in Lexington? In June 2020 the nonprofit organization CivicLex conducted a round of online surveys of Lexington residents in order to gauge how to increase levels of civic knowledge and civic participation in Lexington. This project utilized this survey data, Census data, and 2020 election data to study the effects of age, engagement and trust in Lexington-Fayette Urban County Government, familiarity with their District Councilmember, and education on city council and presidential turnout. I created scatterplots to see if there are any correlations between these variables and …

A Study Of The Improvement Of Weighting Scheme Using Administrative Data In A Panel Data, Sanggi Lee

MPA/MPP/MPFM Capstone Projects

This paper contains a problem that has been studied a lot in the household panel survey, that is, the contents of how to give initial weights to non-sample household members when they enter the sample household. In order to assign an initial weight to an object, information on its sampling probability is required, but it is difficult to obtain the first wave information for non-sampled household members. So, as a solution to this, the shared weights method and modeling method were studied and applied to the actual major household panel surveys. However, the data used in this paper is a …

Broadband Development In Lexington: A Study Of Access And Equity, Alex Sergent

MPA/MPP/MPFM Capstone Projects

Broadband equity is at the forefront of today’s issues. Those that have the ability to access the internet regularly from home are given an opportunity to participate in countless social, work, and learning opportunities that those without access must forgo. It is difficult to determine where broadband infrastructure fails. Through this study of Lexington-Fayette Urban County, it was found that connection within Urban Service Boundaries is on par with national goals, while rural areas are left out. This paper contains a descriptive analysis of the overall broadband access equity of Lexington-Fayette county.

Defunding The Police: True Police Reform Or Just Political Smoke And Mirrors? A Look At The City Of Camden, New Jersey And Its Approach To Police Reform, Anitra Austin

MPA/MPP/MPFM Capstone Projects

The summer of 2020 brought police brutality to the forefront of society. The deaths of Breonna Taylor and George Floyd at the hands of police officers ignited a firestorm of social justice movements. Black Lives Matter and other social justice organizations were calling for cities around the country to defund their police departments as a strategy for police reform. This strategy was largely unprecedented, and highly controversial. There was a lack of understanding of what defunding the police actually meant, as it seemed to mean different things to different people. The subtle suggestions of defunding the police quickly turned to …

Sunset Provisions In The Local Tax Code: Best Practices, Sara Deuster

MPA/MPP/MPFM Capstone Projects

The primary objective of this research project is to identify the main uses of the sunset provision as it relates to the local tax code. This research project utilizes a case study approach to collect and analyze sunset tax legislation from five municipalities. Capital project funding is found to be the primary use of taxes with a sunset provision. Other uses associated with sunset taxation include transportation infrastructure, capital funding, bond financing, and public safety. Through the analysis process for this research project, five best practices were developed to guide municipalities who engage in sunset taxation with respect to their …

An Analysis Of Krs 123.487 And The Motor Vehicle Tax Rates Levied Among Special Districts In Kentucky, Beth Atkinson

MPA/MPP/MPFM Capstone Projects

Kentucky Revised Statute 132.487 sets forth limitations on the motor vehicle tax rate, which can be levied by the state, counties, cities, and special taxing districts. According to the statute, the rate is formulated on a January 1, 1983 date without exception. However, a lack of oversight and understanding of KRS 132.487 has created problems among counties, cities, and special districts in Kentucky. In some cases, this has led to the adoption of tax rates which violate the statute and should be investigated and addressed by the legislature. This research suggests that non-compliance with KRS 132.487 is more prevalent among …

Merged Government: Is This An Option For Bowling Green And Warren County, Ky Governments?, Alice Williams

MPA/MPP/MPFM Capstone Projects

In recent history, the most common attempt at reorganization of government in a metropolitan area is the city-county consolidation model. With limited government resources, elected officials along with community members look to this model to make the best use of those resources. “Applied to local government, the term ‘‘consolidation’’ is generally understood to mean the structural merging of two or more governments into one. When a city and county consolidate, a new and different form of local government is created that has elements of both city and county government but is neither.” (Martin, 2011) There are both benefits and problems …

Kentucky’S K-12 Public School Spending And Its Relationship To Enrollment Percentages Of Students With Limited English Proficiency And Students Eligible For The Free And Reduced-Price Lunch Program, Christine Tarne

MPA/MPP/MPFM Capstone Projects

Public school funding formulas vary broadly between states in both the levels of funding and the mechanisms through which funding is distributed. Most states provide targeted funding for student populations that need supplemental resources, including low-income and limited English proficiency student populations, as does the Federal Elementary and Secondary Education Act (ESEA). In the past, a lack of school level enrollment and financial data made it difficult to determine whether funding provided to local education agencies has been equitably distributed to the schools with whom they are affiliated. The 2015 Federal Every Student Succeeds Act requires that school-level enrollment and …