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A Global Survey Of Infection Control And Mitigation Measures For Combating The Transmission Of Covid-19 Pandemic In Buildings Under Facilities Management Services, Hadi Sarvari, Zhen Chen, Daniel W. M. Chan, Ellyn A. Lester, Nordin Yahaya, Hala Nassereddine, Aynaz Lotfata Jan 2022

A Global Survey Of Infection Control And Mitigation Measures For Combating The Transmission Of Covid-19 Pandemic In Buildings Under Facilities Management Services, Hadi Sarvari, Zhen Chen, Daniel W. M. Chan, Ellyn A. Lester, Nordin Yahaya, Hala Nassereddine, Aynaz Lotfata

Civil Engineering Faculty Publications

Facilities management along with health care are two important aspects in controlling the spread of infectious diseases with regard to controlling the outbreak of global COVID-19 pandemic. Hence, with the increasing outbreak of COVID-19 pandemic, the importance of examining the relationship between the built environment and the outbreak of infectious diseases has become more significant. The aim of the research described in this article is to develop effective infection control and mitigation measures to prevent the transmission of COVID-19 pandemic in the built environment. This study seeks to answer the question of how the facilities management industry can help reduce …


Blood Flow Restriction Training After Patellar Instability (Brains Trial), Benjamin D. Brightwell, Austin V. Stone, Xiaojuan Li, Peter A. Hardy, Katherine L. Thompson, Brian W. Noehren, Cale A. Jacobs Jan 2022

Blood Flow Restriction Training After Patellar Instability (Brains Trial), Benjamin D. Brightwell, Austin V. Stone, Xiaojuan Li, Peter A. Hardy, Katherine L. Thompson, Brian W. Noehren, Cale A. Jacobs

Orthopaedic Surgery and Sports Medicine Faculty Publications

Background

Patellar instability is a common and understudied condition that disproportionally affects athletes and military personnel. The rate of post-traumatic osteoarthritis that develops following a patellar dislocation can be up to 50% of individuals 5–15 years after injury. Conservative treatment is the standard of care for patellar instability however, there are no evidence-informed rehabilitation guidelines in the scientific literature. The purpose of this study is to assess the effectiveness of blood-flow restriction training (BFRT) for patellar instability. Our hypotheses are that this strategy will improve patient-reported outcomes and accelerate restoration of symmetric strength and knee biomechanics necessary to safely return …


Long-Lasting Impairments In Quadriceps Mitochondrial Health, Muscle Size, And Phenotypic Composition Are Present After Non-Invasive Anterior Cruciate Ligament Injury, Steven M. Davi, Ahram Ahn, Mckenzie S. White, Timothy A. Butterfield, Kate Kosmac, Oh Sung Kwon, Lindsey K. Lepley Jan 2022

Long-Lasting Impairments In Quadriceps Mitochondrial Health, Muscle Size, And Phenotypic Composition Are Present After Non-Invasive Anterior Cruciate Ligament Injury, Steven M. Davi, Ahram Ahn, Mckenzie S. White, Timothy A. Butterfield, Kate Kosmac, Oh Sung Kwon, Lindsey K. Lepley

Center for Muscle Biology Faculty Publications

Introduction: Despite rigorous rehabilitation aimed at restoring muscle health, anterior cruciate ligament (ACL) injury is often hallmarked by significant long-term quadriceps muscle weakness. Derangements in mitochondrial function are a common feature of various atrophying conditions, yet it is unclear to what extent mitochondria are involved in the detrimental sequela of quadriceps dysfunction after ACL injury. Using a preclinical, non-invasive ACL injury rodent model, our objective was to explore the direct effect of an isolated ACL injury on mitochondrial function, muscle atrophy, and muscle phenotypic transitions.

Methods: A total of 40 male and female, Long Evans rats (16-week-old) were exposed to …


Antitrust Can't Tame Inequality, Let Alone Inflation, Ramsi Woodcock Jan 2022

Antitrust Can't Tame Inequality, Let Alone Inflation, Ramsi Woodcock

Law Faculty Popular Media

The Biden administration’s plans to take antitrust action to head off inflation are splitting progressives, with some openly rejecting the notion that monopolies are to blame for surging prices and others arguing that even if the initiative fails to tame inflation, more antitrust enforcement can only be a good thing.

What both sides should be questioning is not whether applying antitrust to inflation is too much of a good thing, but whether antitrust is good for progressives at all. Because, as I explain in a recent paper, an inconvenient truth about competition is that it breeds inequality — something economists …


A Global Survey Of Infection Control And Mitigation Measures For Combating The Transmission Of Covid-19 Pandemic In Buildings Under Facilities Management Services, Hadi Savari, Zhen Chen, Daniel W. M. Chan, Ellyn A. Lester, Nordin Bin Yahaya, Hala Nassereddine, Aynaz Lotfata Jan 2022

A Global Survey Of Infection Control And Mitigation Measures For Combating The Transmission Of Covid-19 Pandemic In Buildings Under Facilities Management Services, Hadi Savari, Zhen Chen, Daniel W. M. Chan, Ellyn A. Lester, Nordin Bin Yahaya, Hala Nassereddine, Aynaz Lotfata

Civil Engineering Faculty Publications

Facilities management along with health care are two important aspects in controlling the spread of infectious diseases with regard to controlling the outbreak of global COVID-19 pandemic. Hence, with the increasing outbreak of COVID-19 pandemic, the importance of examining the relationship between the built environment and the outbreak of infectious diseases has become more significant. The aim of the research described in this article is to develop effective infection control and mitigation measures to prevent the transmission of COVID-19 pandemic in the built environment. This study seeks to answer the question of how the facilities management industry can help reduce …


Forage Systems To Optimize Agronomic And Economic Performance In Organic Dairy Systems, S. Ray Smith, G. Pighetti, D. M. Butler, Kenneth H. Burdine, Krista Lea, K. Mercier, K. Payne, J. Allison, Gary E. Bates, N. Colton, A. Rius, P. Krawczel, E. Eckelkamp Jan 2022

Forage Systems To Optimize Agronomic And Economic Performance In Organic Dairy Systems, S. Ray Smith, G. Pighetti, D. M. Butler, Kenneth H. Burdine, Krista Lea, K. Mercier, K. Payne, J. Allison, Gary E. Bates, N. Colton, A. Rius, P. Krawczel, E. Eckelkamp

IGC Proceedings (1977-2023)

Organic dairy production in the USA is growing, but most forage systems research focuses on conventional production practices. As a result, organic dairy producers have limited science-based information to assist with farm and livestock management. The objective of this project was to use a multi-faceted approach to determine the ideal species mixtures for organic dairy production as well as document forage quality, forage yield, soil characteristics, milk production and milk quality during the grazing season. The forages studied ranged from a single species monoculture to a four species mixture of warm and cool season grasses and legumes. Nine distinct forage …


Fodder Crop Adoption Through Push-Pull Technology (Ppt) For Fall Armyworm (Faw) Control In Cereals Cropping Systems, Michael N. Njunie, E. N. Muthiani, A. Mzingirwa, N. F. Pole, B. M. Muli, A. O. Esilaba Jan 2022

Fodder Crop Adoption Through Push-Pull Technology (Ppt) For Fall Armyworm (Faw) Control In Cereals Cropping Systems, Michael N. Njunie, E. N. Muthiani, A. Mzingirwa, N. F. Pole, B. M. Muli, A. O. Esilaba

IGC Proceedings (1977-2023)

There is an urgent need to increase grain yields and animal products due to increasing human population in Africa. Push-pull technology (PPT) is a conservation agriculture intercrop technology which protects and enhances natural resources productivity and ecosystem services in mixed farming systems. The technology involves growing of a cereal crop with a repellent intercrop, Desmodium genus (silverleaf, D. uncinatum and greenleaf, D. intortum) with grass such as Pennisetum purpureum or Brachiaria spp. planted as a border around the cereal-legume intercrop. The plants accompanying the cereal crop are typically valuable high quality fodder thus integrating crop-livestock production. The PPT was …


Evaluation Of The Chemical And Biological Characteristics Of Sake Lees, S. Katsumata, S. Yamanaka, M. Yamauchi, H. Hirooka, H. Kumagai Jan 2022

Evaluation Of The Chemical And Biological Characteristics Of Sake Lees, S. Katsumata, S. Yamanaka, M. Yamauchi, H. Hirooka, H. Kumagai

IGC Proceedings (1977-2023)

Sake lees (SLs), produced from brewing Japanese Sake and known to be rich in yeast, is expected to be an alternative of feed protein sources for ruminants. Previous studies showed that yeast improved the digestibility of fibers in ruminants. However, the nutrient composition and the numbers of live and dead yeast in the SLs, have large diversity because of the different brewing materials and processes. The objective of this study was to evaluate the chemical and biological characteristics of SLs with diverse brewing processes and storing periods (0-23 weeks). Seven types of SLs (SLs 1-7) were collected from two breweries. …


Effect Of High-Intensity, Short-Duration Grazing On Species Density And Botanical Composition Of Arid Rangelands, Mounir Louhaichi, Mouldi Gamoun, Fethi Gouhis, Ezzeddine Belfekih, Mohamed Abdelkader Jan 2022

Effect Of High-Intensity, Short-Duration Grazing On Species Density And Botanical Composition Of Arid Rangelands, Mounir Louhaichi, Mouldi Gamoun, Fethi Gouhis, Ezzeddine Belfekih, Mohamed Abdelkader

IGC Proceedings (1977-2023)

Rangelands are the mainstay of pastoral and agropastoral livelihoods worldwide. They have provided forage for livestock and wildlife for centuries, but steady degradation of rangelands is causing increasing concern. Many rangeland managers believe exclusion of livestock grazing for extended periods would allow degraded rangelands to recover. The purpose of this current ongoing research is to evaluate the effect of high-intensity short-duration grazing on plant density, species richness and botanical composition on arid rangelands during favorable years. The site, which is protected for two years in southern Tunisia and covers an area of 6 ha, was grazed by a flock of …


Economics Of Greenhouse Gas Mitigation Strategies In A North-Eastern Brazilian Beef Production System, K. Agethen, Rogerio M. Mauricio, C. Deblitz Jan 2022

Economics Of Greenhouse Gas Mitigation Strategies In A North-Eastern Brazilian Beef Production System, K. Agethen, Rogerio M. Mauricio, C. Deblitz

IGC Proceedings (1977-2023)

The state of Maranhão, Brazil, has been among the country’s fastest-growing cattle regions in recent years and it now faces important conflicts for beef production. Pasture degradation, low cattle productivity, and land-use changes due to agriculture and forestry expansion are key challenges. Additionally, beef production systems are a focus for emissions reduction, particularly in the context of increasing deforestation and its impact on global warming. A sustainable intensification of currently used pastures, enhancing economic viability and reducing environmental effects of beef production can help to mitigate the climate impact. Since economics is an important incentive in the decision-making processes of …


Optimizing Mandibular Advancement Maneuvers During Sleep Endoscopy With A Titratable Positioner: Dise-Sam Protocol, Patricia Fernández-Sanjuán, Juan José Arrieta, Jaime Sanabria, Marta Alcaraz, Gabriela Bosco, Nuria Pérez-Martín, Adriana Pérez, Marina Carrasco-Llatas, Isabel Moreno-Hay, Marcos Ríos-Lago, Rodolfo Lugo, Carlos O’Connor-Reina, Peter Baptista, Guillermo Plaza Jan 2022

Optimizing Mandibular Advancement Maneuvers During Sleep Endoscopy With A Titratable Positioner: Dise-Sam Protocol, Patricia Fernández-Sanjuán, Juan José Arrieta, Jaime Sanabria, Marta Alcaraz, Gabriela Bosco, Nuria Pérez-Martín, Adriana Pérez, Marina Carrasco-Llatas, Isabel Moreno-Hay, Marcos Ríos-Lago, Rodolfo Lugo, Carlos O’Connor-Reina, Peter Baptista, Guillermo Plaza

Oral Health Science Faculty Publications

Mandibular advancement devices (MAD) are an effective alternative treatment to CPAP. Different maneuvers were performed during drug sleep-induced endoscopy (DISE) to mimic the effect of MAD. Using the Selector Avance Mandibular (SAM) device, we aimed to identify MAD candidates during DISE using a titratable, reproducible, and measurable maneuver. This DISE-SAM protocol may help to find the relationship between the severity of the respiratory disorder and the degree of response and determine the advancement required to improve the collapsibility of the upper airway. Explorations were performed in 161 patients (132 males; 29 females) with a mean age of 46.81 (SD = …


Form Of Supplemental Selenium Affects The Expression Of Mrna Transcripts Encoding Selenoproteins, And Proteins Regulating Cholesterol Uptake, In The Corpus Luteum Of Grazing Beef Cows, Sarah N. Carr, Benjamin R. Crites, Joy L. Pate, Camilla H. K. Hughes, James C. Matthews, Phillip J. Bridges Jan 2022

Form Of Supplemental Selenium Affects The Expression Of Mrna Transcripts Encoding Selenoproteins, And Proteins Regulating Cholesterol Uptake, In The Corpus Luteum Of Grazing Beef Cows, Sarah N. Carr, Benjamin R. Crites, Joy L. Pate, Camilla H. K. Hughes, James C. Matthews, Phillip J. Bridges

Animal and Food Sciences Faculty Publications

Selenium (Se)-deficient soils necessitate supplementation of this mineral to the diet of forage-grazing cattle. Functionally, Se is incorporated into selenoproteins, some of which function as important antioxidants. We have previously shown that the source of supplemental Se; inorganic (sodium selenite or sodium selenate; ISe), organic (selenomethionine or selenocysteine; OSe) or 1:1 mix of ISe and OSe (MIX), provided to Angus-cross cows affects concentrations of progesterone (P4) during the early luteal phase of the estrous cycle. In this study, we sought to investigate (1) the effect of form of Se on the expression of mRNA encoding selenoproteins in the corpus luteum …


Form Of Supplemental Selenium Affects The Expression Of Mrna Transcripts Encoding Selenoproteins, And Proteins Regulating Cholesterol Uptake, In The Corpus Luteum Of Grazing Beef Cows, Sarah Carr, Benjamin R. Crites, Joy Pate, Camilla Hughes, James C. Matthews, Phillip J. Bridges Jan 2022

Form Of Supplemental Selenium Affects The Expression Of Mrna Transcripts Encoding Selenoproteins, And Proteins Regulating Cholesterol Uptake, In The Corpus Luteum Of Grazing Beef Cows, Sarah Carr, Benjamin R. Crites, Joy Pate, Camilla Hughes, James C. Matthews, Phillip J. Bridges

Animal and Food Sciences Graduate Research

Selenium (Se)-deficient soils necessitate supplementation of this mineral to the diet of forage-grazing cattle. Functionally, Se is incorporated into selenoproteins, some of which function as important antioxidants. We have previously shown that the source of supplemental Se; inorganic (sodium selenite or sodium selenate; ISe), organic (selenomethionine or selenocysteine; OSe) or 1:1 mix of ISe and OSe (MIX), provided to Angus-cross cows affects concentrations of progesterone (P4) during the early luteal phase of the estrous cycle. In this study, we sought to investigate (1) the effect of form of Se on the expression of mRNA encoding selenoproteins in the corpus luteum …


Gut Microbial Trimethylamine Is Elevated In Alcohol-Associated Hepatitis And Contributes To Ethanol-Induced Liver Injury In Mice, Robert N. Helsley, Tatsunori Miyata, Anagha Kadam, Venkateshwari Varadharajan, Naseer Sangwan, Emily C. Huang, Rakhee Banerjee, Amanda L. Brown, Kevin K. Fung, William J. Massey, Chase Neumann, Danny Orabi, Lucas J. Osborn, Rebecca C. Schugar, Megan R. Mcmullen, Annette Bellar, Kyle L. Poulsen, Adam Kim, Vai Pathak, Marko Mrdjen Jan 2022

Gut Microbial Trimethylamine Is Elevated In Alcohol-Associated Hepatitis And Contributes To Ethanol-Induced Liver Injury In Mice, Robert N. Helsley, Tatsunori Miyata, Anagha Kadam, Venkateshwari Varadharajan, Naseer Sangwan, Emily C. Huang, Rakhee Banerjee, Amanda L. Brown, Kevin K. Fung, William J. Massey, Chase Neumann, Danny Orabi, Lucas J. Osborn, Rebecca C. Schugar, Megan R. Mcmullen, Annette Bellar, Kyle L. Poulsen, Adam Kim, Vai Pathak, Marko Mrdjen

Pediatrics Faculty Publications

There is mounting evidence that microbes residing in the human intestine contribute to diverse alcohol-associated liver diseases (ALD) including the most deadly form known as alcohol-associated hepatitis (AH). However, mechanisms by which gut microbes synergize with excessive alcohol intake to promote liver injury are poorly understood. Furthermore, whether drugs that selectively target gut microbial metabolism can improve ALD has never been tested. We used liquid chromatography tandem mass spectrometry to quantify the levels of microbe and host choline co-metabolites in healthy controls and AH patients, finding elevated levels of the microbial metabolite trimethylamine (TMA) in AH. In subsequent studies, we …


Human Microrna (Mir-20b-5p) Modulates Alzheimer’S Disease Pathways And Neuronal Function, And A Specific Polymorphism Close To The Mir20b Gene Influences Alzheimer’S Biomarkers, Ruizhi Wang, Nipun Chopra, Kwangsik Nho, Bryan Maloney, Alexander G. Obukhov, Peter T. Nelson, Scott E. Counts, Debomoy K. Lahiri Jan 2022

Human Microrna (Mir-20b-5p) Modulates Alzheimer’S Disease Pathways And Neuronal Function, And A Specific Polymorphism Close To The Mir20b Gene Influences Alzheimer’S Biomarkers, Ruizhi Wang, Nipun Chopra, Kwangsik Nho, Bryan Maloney, Alexander G. Obukhov, Peter T. Nelson, Scott E. Counts, Debomoy K. Lahiri

Sanders-Brown Center on Aging Faculty Publications

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with loss of cognitive, executive, and other mental functions, and is the most common form of age-related dementia. Amyloid-β peptide (Aβ) contributes to the etiology and progression of the disease. Aβ is derived from the amyloid-β precursor protein (APP). Multiple microRNA (miRNA) species are also implicated in AD. We report that human hsa-miR20b-5p (miR-20b), produced from the MIR20B gene on Chromosome X, may play complex roles in AD pathogenesis, including Aβ regulation. Specifically, miR-20b-5p miRNA levels were altered in association with disease progression in three regions of the human brain: temporal neocortex, …


Rangeland Degradation In Mongolia – Using State And Transition Models To Help Understand Rangeland Dynamics, S. Sainnemekh, B. Densambuu, B. Bestelmeyer, I. C. Barrio, A. L. Aradóttir Jan 2022

Rangeland Degradation In Mongolia – Using State And Transition Models To Help Understand Rangeland Dynamics, S. Sainnemekh, B. Densambuu, B. Bestelmeyer, I. C. Barrio, A. L. Aradóttir

IGC Proceedings (1977-2023)

Rangeland degradation and soil erosion pose constant challenges to the management of natural resources in Mongolia. Large increases in livestock numbers since the early 1990s, together with increasing temperatures and higher frequency of extreme weather events have led to widespread degradation of rangeland resources, to the extent that today, nearly 57% of rangelands in Mongolia are considered degraded to some degree. New ways of understanding the dynamics of rangeland ecosystems and guidelines to conserve healthy and productive rangelands are urgently needed. The application of State and Transition Models (STMs) in ecosystem management has shown promise to understand the mechanistic processes …


An Approach To Evaluate Soils Influence On Floristic Composition Of Natural Grasslands, F. L. F. De Quadros, R. M. R. De Carvalho, R. Farenzena, L. Marin, P. L. Nascimento Jan 2022

An Approach To Evaluate Soils Influence On Floristic Composition Of Natural Grasslands, F. L. F. De Quadros, R. M. R. De Carvalho, R. Farenzena, L. Marin, P. L. Nascimento

IGC Proceedings (1977-2023)

This trial aims to evaluate floristic composition of most abundant species in three soil typical of Pampa biome on Brazil. The survey was held at Maronna Fundation located on southern Alegrete municipality, on Rio Grande do Sul, Brazil’s state. Regional climate belongs to Koeppen’s Cfa class. Soil types were shallow basalt (Psamments e Orthents), deep basalt (Vertisols) and sandy soil (Acrisols or Ultisols). Floristic composition were evaluated by visual ranking of aerial biomass of the major species (transformed to kg of dry matter per hectare), calibrated by cuts at ground level, according to field procedures of BOTANAL method. Grasses were …


Interindividual Differences And Their Consistency In Grazing Cattle Behavior Across Seasons, H. Anzai, M. Shitajikkoku, K. Hani, N. Yamada, M. Hirata Jan 2022

Interindividual Differences And Their Consistency In Grazing Cattle Behavior Across Seasons, H. Anzai, M. Shitajikkoku, K. Hani, N. Yamada, M. Hirata

IGC Proceedings (1977-2023)

Interindividual differences and their consistency in behavior were investigated for cattle (Bos taurus) grazing a bahiagrass (Paspalum notatum) and centipedegrass (Eremochloa ophiuroides) dominated pasture as a herd of about 30 breeding cows with their calves. Behavior of the cows was monitored directly by observers and also using GPS and accelerometer data loggers attached to focal cows for a period of 1–5 days every month during the grazing seasons (from May to October) in 2018 and 2019. The data were converted into behavioral variables (e.g. time spent grazing, ruminating and resting, time spent in particular …


Biodiversity Assessment And Conservation Of Threatened Plant Species Belonging To The Unique Steppe With Trees In Tunisian Drylands, Jamila Msadek, Mohamed Tarhouni Jan 2022

Biodiversity Assessment And Conservation Of Threatened Plant Species Belonging To The Unique Steppe With Trees In Tunisian Drylands, Jamila Msadek, Mohamed Tarhouni

IGC Proceedings (1977-2023)

Biodiversity conservation from heavy grazing impacts, through the creation of national parks, is usually considered to sustain higher ecosystem resilience and to protect the natural plant cover as well as the threatened species. The study was carried out in Bou Hedma national park, a biosphere reserve containing the unique Acacia tortilis (Forssk.) Hayne subsp. raddiana (Savi) Brenan steppe with trees in Tunisia. Several functional traits of seven (7) rare and threatened plant species are used to highlight their adaptive strategies in order to understand the evolution of plant communities and the overall ecosystems functioning inside the park. Such results may …


Vegetation Response To Grazing Pressure In The Puna Flat, Nw Argentina, M. Quiroga Mendiola, A. Tálamo Jan 2022

Vegetation Response To Grazing Pressure In The Puna Flat, Nw Argentina, M. Quiroga Mendiola, A. Tálamo

IGC Proceedings (1977-2023)

Puna grasslands are located at a high‐altitude flat plateau in the Northwest of Argentina. It is an arid territory (100 to 300 mm rainfall/year) at 3,000 to 4,000 m a.s.l. The vegetation is scarce, where Andean pastoralist communities produce meat and wool, specialized in llama (Lama glama) and sheep‐breeding, although they do breed multi‐species herds that may also include goats and cattle. There are erosion processes in the Puna, where shepherds and their animals could be synergetic factors with natural very hard climatic conditions. In this work we assess the effect of ovine and lama grazing on the …


Grass Species Density And Biomass Of South African Communal Property Association Farms Differing In Soil Properties, K. E. Ravhuhali, B. Moyo Jan 2022

Grass Species Density And Biomass Of South African Communal Property Association Farms Differing In Soil Properties, K. E. Ravhuhali, B. Moyo

IGC Proceedings (1977-2023)

Attempts to monitor and mitigate rangeland deterioration in Communal Property Associations projects require some understanding of the knowledge of species composition and distribution. The study was conducted to compare the herbaceous in three selected CPAs projects (Mashung Matlala - Sandy loam, Mawela - clay loam, and Bela-Bela - clay) in South Africa. Mawela and Mashung Matlala CPAs were overgrazed. For species density, basal strike, and biomass, three transects (500m), which served as replicates, were established at two camps of each of the selected CPAs. Variation in herbaceous vegetation parameters was explored through SAS software. Clay soil type had better (P …


Therapeutic Treatment With The Anti-Inflammatory Drug Candidate Mw151 May Partially Reduce Memory Impairment And Normalizes Hippocampal Metabolic Markers In A Mouse Model Of Comorbid Amyloid And Vascular Pathology, David J. Braun, David K. Powell, Christopher J. Mclouth, Saktimayee M. Roy, D. Martin Watterson, Linda J. Van Eldik Jan 2022

Therapeutic Treatment With The Anti-Inflammatory Drug Candidate Mw151 May Partially Reduce Memory Impairment And Normalizes Hippocampal Metabolic Markers In A Mouse Model Of Comorbid Amyloid And Vascular Pathology, David J. Braun, David K. Powell, Christopher J. Mclouth, Saktimayee M. Roy, D. Martin Watterson, Linda J. Van Eldik

Neuroscience Faculty Publications

Alzheimer's disease (AD) is the leading cause of dementia in the elderly, but therapeutic options are lacking. Despite long being able to effectively treat the ill-effects of pathology present in various rodent models of AD, translation of these strategies to the clinic has so far been disappointing. One potential contributor to this situation is the fact that the vast majority of AD patients have other dementia-contributing comorbid pathologies, the most common of which are vascular in nature. This situation is modeled relatively infrequently in basic AD research, and almost never in preclinical studies. As part of our efforts to develop …


Path Integral Complexity And Kasner Singularities, Pawel Caputa, Diptarka Das, Sumit R. Das Jan 2022

Path Integral Complexity And Kasner Singularities, Pawel Caputa, Diptarka Das, Sumit R. Das

Physics and Astronomy Faculty Publications

We explore properties of path integral complexity in field theories on time dependent backgrounds using its dual description in terms of Hartle-Hawking wavefunctions. In particular, we consider boundary theories with time dependent couplings which are dual to Kasner-AdS metrics in the bulk with a time dependent dilaton. We show that holographic path integral complexity decreases as we approach the singularity, consistent with earlier results from holographic complexity conjectures. Furthermore, we find examples where the complexity becomes universal i.e., independent of the Kasner exponents, but the properties of the path integral tensor networks depend sensitively on this data.


Therapeutic Treatment With The Anti-Inflammatory Drug Candidate Mw151 May Partially Reduce Memory Impairment And Normalizes Hippocampal Metabolic Markers In A Mouse Model Of Comorbid Amyloid And Vascular Pathology, David J. Braun, David K. Powell, Christopher J. Mclouth, Saktimayee M. Roy, D. Martin Watterson, Linda J. Van Eldik Jan 2022

Therapeutic Treatment With The Anti-Inflammatory Drug Candidate Mw151 May Partially Reduce Memory Impairment And Normalizes Hippocampal Metabolic Markers In A Mouse Model Of Comorbid Amyloid And Vascular Pathology, David J. Braun, David K. Powell, Christopher J. Mclouth, Saktimayee M. Roy, D. Martin Watterson, Linda J. Van Eldik

Sanders-Brown Center on Aging Faculty Publications

Alzheimer’s disease (AD) is the leading cause of dementia in the elderly, but therapeutic options are lacking. Despite long being able to effectively treat the ill-effects of pathology present in various rodent models of AD, translation of these strategies to the clinic has so far been disappointing. One potential contributor to this situation is the fact that the vast majority of AD patients have other dementia-contributing comorbid pathologies, the most common of which are vascular in nature. This situation is modeled relatively infrequently in basic AD research, and almost never in preclinical studies. As part of our efforts to develop …


The Type And Quantity Of Plant Litter Influences The Plant Functional Group Growth In An Alpine Meadow, Zhouwen Ma, Fujiang Hou Jan 2022

The Type And Quantity Of Plant Litter Influences The Plant Functional Group Growth In An Alpine Meadow, Zhouwen Ma, Fujiang Hou

IGC Proceedings (1977-2023)

Plant functional group (PFG) diversity in a grassland is an important measure of productivity and health. Litter is known to be major driving factors of soil-grass feedbacks in natural grassland. The shift in PFG composition is a significant change that can result many ecological consequences such as litter composition and dynamics (Dong et al., 2019). Decomposition of litter can affect the nutrient and allelochemicals cycling of soil, which affects seed germination and establishment of seedlings (Yuan et al., 2015). Furthermore, PFG characteristics can vary via inputs of the quality or quantity of litter (Galvánek & Lepš, 2012). These compositional changes …


The Functional Importance Of Forbs In Grassland Ecosystems, F. Siebert, C. Morris, S. Chamane, N. Ntuli, S. J. Siebert Jan 2022

The Functional Importance Of Forbs In Grassland Ecosystems, F. Siebert, C. Morris, S. Chamane, N. Ntuli, S. J. Siebert

IGC Proceedings (1977-2023)

Herbaceous vegetation in grassland ecosystems is characterised by grass dominance in a species-rich forb-grass mixture. Forbs (i.e. the non-graminoid herbaceous component) represent the largest proportion of total species- and functional richness, which secure important ecosystem functions. Although grasses remain the most important forage source, certain forb species provide nutritious food sources for herbivores. Moreover, forbs provide food- and habitat sources to enhance invertebrate diversity and hence, agricultural food security through the maintenance of healthy pollinator communities. Important food and medicinal sources for human livelihoods in developing countries are also largely contributed by forbs. However, the dynamics and ecology of forb …


The Effects Of Chemical And Mechanical Control Of Woody Plants On Resprouting And Seedling Production In Communal Rangelands, P. Monegi, N. R. Mkhize, T. J. Tjelele, D. Ward, Z. Tsvuura Jan 2022

The Effects Of Chemical And Mechanical Control Of Woody Plants On Resprouting And Seedling Production In Communal Rangelands, P. Monegi, N. R. Mkhize, T. J. Tjelele, D. Ward, Z. Tsvuura

IGC Proceedings (1977-2023)

In many African countries, communal rangelands are threatened by woody plant encroachment. We sought to explore potential solutions for communal ranchers that would be cost-effective. We conducted two field experiments to determine (1) the effects of various tree removal treatments (10%, 20%, 50%, 75% and 100%), and herbicide application on resprouting ability and vigour of several woody plant species; and (2) the effectiveness of Tree Poppers® (a weed wrench) as a low-cost mechanical control tool to physically uproot seedlings and saplings of woody species. In the first experiment, we examined 12 plant species from 20 plots (30 m x 30 …


‘Cachena’, A Bovine Rustic Portuguese Extensively Reared Autochthonous Breed: Meat Texture Analysis, M. E. Potes, S. Ricardo-Rodrigues, M. Laranjo, A. C. Agulheiro-Santos, M. Elias Jan 2022

‘Cachena’, A Bovine Rustic Portuguese Extensively Reared Autochthonous Breed: Meat Texture Analysis, M. E. Potes, S. Ricardo-Rodrigues, M. Laranjo, A. C. Agulheiro-Santos, M. Elias

IGC Proceedings (1977-2023)

‘Cachena’ is one of the world’s smallest bovine breeds. Extremely rustic and wild, they are extensively reared, and fed with natural pastures. Meat valorisation is essential to preserve this breed, with a limited livestock.

‘Cachena’’s meat is tender, juicy, low-fat, and highly appreciated due to the association of animal, terroir and producer, balanced by the ecosystem’s sustainability.

The aim of this study was to increase the weight of Longissimus dorsi (LD) and Psoas major (PM) muscles, without depreciating their sensory quality.

Two groups of 16 animals were slaughtered: (A) 9-17 months old animals with 140-225 kg slaughter live weight (SLW); …


Assessing Feed Gaps On Smallholder Livestock Farms In Limpopo: Production System And Coping Strategies, S. A. Lamega, M. Komainda, M. P. Hoffmann, J. J. Odhiambo, K. K. Ayisi, J. Isselstein Jan 2022

Assessing Feed Gaps On Smallholder Livestock Farms In Limpopo: Production System And Coping Strategies, S. A. Lamega, M. Komainda, M. P. Hoffmann, J. J. Odhiambo, K. K. Ayisi, J. Isselstein

IGC Proceedings (1977-2023)

Smallholder farms in southern Africa are predominantly mixed crop-livestock systems and often characterized by low productivity. Therefore, providing sufficient forage becomes a challenge that results first in feed gaps, i.e. the difference between the demand for and supply of forage, and secondly, in nutrient mining of the soil due to the overuse of the resources. However, the availability of forage follows potentially seasonal patterns. Hence, a key entry point for any intervention strategies for improvement is an assessment of forage quantity and quality throughout the year. Against this background, we investigated six locations, smallholders’ cattle production systems and their adaptation …


A Novel Approach For Real-Time Quality Monitoring In Machining Of Aerospace Alloy Through Acoustic Emission Signal Transformation For Dnn, David Adeniji, Kyle Oligee, Julius Schoop Jan 2022

A Novel Approach For Real-Time Quality Monitoring In Machining Of Aerospace Alloy Through Acoustic Emission Signal Transformation For Dnn, David Adeniji, Kyle Oligee, Julius Schoop

Mechanical Engineering Faculty Publications

Gamma titanium aluminide (γ-TiAl) is considered a high-performance, low-density replacement for nickel-based superalloys in the aerospace industry due to its high specific strength, which is retained at temperatures above 800 °C. However, low damage tolerance, i.e., brittle material behavior with a propensity to rapid crack propagation, has limited the application of γ-TiAl. Any cracks introduced during manufacturing would dramatically lower the useful (fatigue) life of γ-TiAl components, making the workpiece surface’s quality from finish machining a critical component to product quality and performance. To address this issue and enable more widespread use of γ-TiAl, this research aims to develop a …