Digital Commons Network^™

Potential Benefits Of Combined Statin And Metformin Therapy On Resistance Training Response In Older Individuals, Douglas E. Long, Kate Kosmac, Cory M. Dungan, Marcas M. Bamman, Charlotte A. Peterson, Phillip A. Kern

Clinical and Translational Science Faculty Publications

Metformin and statins are currently the focus of large clinical trials testing their ability to counter age-associated declines in health, but recent reports suggest that both may negatively affect skeletal muscle response to exercise. However, it has also been suggested that metformin may act as a possible protectant of statin-related muscle symptoms. The potential impact of combined drug use on the hypertrophic response to resistance exercise in healthy older adults has not been described. We present secondary statin analyses of data from the MASTERS trial where metformin blunted the hypertrophy response in healthy participants (>65 years) following 14 weeks …

Association Between Concussions And Suicidality In High School Students In The United States, Grant L. Iverson, Justin E. Karr

Sanders-Brown Center on Aging Faculty Publications

Importance: Prior research has shown a statistically significant association between sustaining a concussion and suicidality in adolescents, but this prior research controlled for relatively few variables predictive of suicidality.

Objective: To examine whether sustaining a concussion remained a significant predictor of suicidality after controlling for relevant covariates (e.g., sexual abuse/assault, bullying, substance use, depression), hypothesizing that the relationship between concussion and suicidality would become non-significant after controlling for these variables.

Design: This study involved secondary data analysis of the 2019 Youth Risk Behavior Surveillance (YRBS) System, a national cross-sectional study of adolescents. Analyses were stratified by gender. …

Manifestations Of Alzheimer’S Disease Genetic Risk In The Blood Are Evident In A Multiomic Analysis In Healthy Adults Aged 18 To 90, Laura Heath, John C. Earls, Andrew T. Magis, Sergey A. Kornilov, Jennifer C. Lovejoy, Cory C. Funk, Noa Rappaport, Benjamin A. Logsdon, Lara M. Mangravite, Brian W. Kunkle, Eden R. Martin, Adam C. Naj, Nilüfer Ertekin-Taner, Todd E. Golde, Leroy Hood, Nathan D. Price, Erin Abner, David W. Fardo, Linda J. Van Eldik, Alzheimer’S Disease Genetics Consortium

Sanders-Brown Center on Aging Faculty Publications

Genetics play an important role in late-onset Alzheimer’s Disease (AD) etiology and dozens of genetic variants have been implicated in AD risk through large-scale GWAS meta-analyses. However, the precise mechanistic effects of most of these variants have yet to be determined. Deeply phenotyped cohort data can reveal physiological changes associated with genetic risk for AD across an age spectrum that may provide clues to the biology of the disease. We utilized over 2000 high-quality quantitative measurements obtained from blood of 2831 cognitively normal adult clients of a consumer-based scientific wellness company, each with CLIA-certified whole-genome sequencing data. Measurements included: clinical …

Pivoting Standard Services For A New Remote Reality, Kopana Terry

Library Presentations

As the internet has gained popularity over the past 20 years, the Louie B. Nunn Center for Oral History at the University of Kentucky Libraries has adapted by improving search and discovery through our catalogue and content management system Spokedb, the Oral History Metadata Synchronizer (OHMS), and mass digitization of analogue interviews. The sudden COVID-19 Pandemic shut down the face-to-face world and forced us to quickly devise methods for our other not-so-digital services such as interviewing, accessioning, preservation, and the workflows they rely on. This presentation will explore the methods behind these adjustments and how they have become tools in …

Acute Kidney Injury Contributes To Worse Physical And Quality Of Life Outcomes In Survivors Of Critical Illness, Kirby P. Mayer, Victor M. Ortiz-Soriano, Alborz Kalantar, Joshua Lambert, Peter E. Morris, Javier A. Neyra

Physical Therapy Faculty Publications

Objectives: Survivors of critical illness and acute kidney injury (AKI) are at risk of increased morbidity. The purpose of this study was to compare physical, emotional, and cognitive health in survivors of critical illness with and without AKI.

Methods: Retrospective cohort study of adult (≥ 18 years old) survivors of critical illness due to sepsis and/or acute respiratory failure who attended follow-up in a specialized ICU Recovery Clinic. Outcomes were evaluated during 3-month visit and comprised validated tests for evaluation of physical function, muscle strength, cognitive and emotional health, and self-reported health-related quality of life (HRQOL). Descriptive statistics …

Evaluating Simulation-Based Tobacco Treatment Scenarios For Providers Delivering Treatment For People Living With Mental Illnesses, Chizimuzo T. C. Okoli, Janet Otachi, Sarret Seng, Bassema Abufarsakh, Lovoria B. Williams

Clinical and Translational Science Faculty Publications

Background: People living with mental illnesses (PMI) experience elevated tobacco use and related morbidity and mortality. Despite the availability of effective and safe tobacco treatments along with evidence that PMI are motivated and able to quit successfully, few Mental and behavioral healthcare providers (MHPs) engage PMI in such treatment. MHPs may lack the confidence or skills to engage their clients in tobacco treatment. Currently, there are limited training modalities to prepare MHPs in delivering tobacco treatment for PMI. However, animated scenario-based simulated encounters can bridge this gap to effectively provide tailored MHP training to enhance treatment delivery. Hence, the purpose …

Patterns Of Amygdala Region Pathology In Late-Nc: Subtypes That Differ With Regard To Tdp-43 Histopathology, Genetic Risk Factors, And Comorbid Pathologies, Matthew D. Cykowski, Anithachristy S. Arumanayagam, Suzanne Z. Powell, Andreana L. Rivera, Erin L. Abner, Gustavo C. Roman, Joseph C. Masdeu, Peter T. Nelson

Sanders-Brown Center on Aging Faculty Publications

Transactive response (TAR) DNA-binding protein 43 kDa (TDP-43) pathology is a hallmark of limbic-predominant agerelated TDP-43 encephalopathy (LATE). The amygdala is afected early in the evolution of LATE neuropathologic change (LATE-NC), and heterogeneity of LATE-NC in amygdala has previously been observed. However, much remains to be learned about how LATE-NC originates and progresses in the brain. To address this, we assessed TDP-43 and other pathologies in the amygdala region of 184 autopsied subjects (median age=85 years), blinded to clinical diagnoses, other neuropathologic diagnoses, and risk genotype information. As previously described, LATE-NC was associated with older age at death, cognitive impairment, …

Southeastern Law Librarian Spring 2022, Seaall

Newsletters

No abstract provided.

In-Situ Calibrated Digital Process Twin Models For Resource Efficient Manufacturing, David Adeniji, Julius Schoop

Mechanical Engineering Faculty Publications

The chief objective of manufacturing process improvement efforts is to significantly minimize process resources such as time, cost, waste, and consumed energy while improving product quality and process productivity. This paper presents a novel physics-informed optimization approach based on artificial intelligence (AI) to generate digital process twins (DPTs). The utility of the DPT approach is demonstrated in the case of finish machining of aerospace components made from gamma titanium aluminide alloy (γ-TiAl). This particular component has been plagued with persistent quality defects, including surface and sub-surface cracks, which adversely affect resource efficiency. Previous process improvement efforts have been restricted to …

Forage News [2022-04], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

No abstract provided.

A Geospatial And Binomial Logistic Regression Model To Prioritize Sampling For Per- And Polyfluorinated Alkyl Substances In Public Water Systems, Sweta Ojha, Ying Li, Nader Rezaei, Ariel Robinson, Anna G. Hoover, Kelly G. Pennell

UK CARES Faculty Publications

As health‐based drinking water standards for per‐ and polyfluorinated alkyl substances (PFAS) continue to evolve, public health and environmental protection decision‐makers must assess exposure risks associated with all public drinking water systems in the United States (US). Unfortunately, current knowledge regarding the presence of PFAS in environmental systems is limited. In this study, a screening approach was established to: (1) identify and direct attention toward potential PFAS hot spots in drinking water sources, (2) prioritize sampling locations, and (3) provide insights regarding the potential PFAS sources that contaminate groundwater and surface water. Our approach incorporates geospatial data from public sources, …

New Insights Into The Genetic Etiology Of Alzheimer’S Disease And Related Dementias, Céline Bellenguez, Fahri Küçükali, Iris Jansen, Luca Kleineidam, Sonia Moreno-Grau, Najaf Amin, Adam C. Naj, Rafael Campos-Martin, David W. Fardo, Yuriko Kastumata, Erin L. Abner, Radb, Gr@Ace, Degesco, Eadi, Gerad, Demgene, Finngen, Adgc, Charge

Sanders-Brown Center on Aging Faculty Publications

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly …

The 1895 Cézanne Show At Vollard’S Revisited, Robert Jensen

Art and Visual Studies Faculty Working Papers

The Cézanne show at Ambroise Vollard’s Paris gallery in November-December 1895 was a watershed moment for both artist and dealer. Both the artist and the dealer’s commercial successes date from this moment. The composition of Cézanne’s collectors was also largely divided by this exhibition. Who they were and what particular paintings they bought are listed below. The relative uniqueness of this solo exhibition is highlighted. The paper also addresses the still open questions as to how the paintings for the show were selected, by whom, and which pictures were included. In doing so it adds to the list of paintings …

Forecast Of Community Total Electric Load And Hvac Component Disaggregation Through A New Lstm-Based Method, Huangjie Gong, Rosemary E. Alden, Aron Patrick, Dan Ionel

Power and Energy Institute of Kentucky Faculty Publications

The forecast and estimation of total electric power demand of a residential community, its baseload, and its heating ventilation and air-conditioning (HVAC) power component, which represents a very large portion of a community electricity usage, are important enablers for optimal energy controls and utility planning. This paper proposes a method that employs machine learning in a multi-step integrated approach. An LSTM model for total electric power at the main circuit feeder is trained using historic multi-year hourly data, outdoor temperature, and solar irradiance. New key temperature indicators, TmHAVC, corresponding to the standby zero-power operation for HVAC systems for summer cooling …

Evaluation Of Manual Infrared Brake Screening Technologies, Joseph Crabtree, Brian Beaven, Jennifer Walton

Kentucky Transportation Center Research Report

The purpose of this project was to install and operate two manual infrared (IR) brake screening systems at Kentucky inspection facilities to enhance the quality of Level 1 safety inspections. A radio button in the inspection software allowed enforcement personnel to indicate when the IR equipment was used to select a truck for inspection. This feature allowed a direct comparison of performance measures (e.g., number of violations identified per inspection, out-of-service rate, etc.) for IR-generated inspections versus all inspections.

The evaluation focused on inspections at the Lyon County site for a 60-day period during September and October 2021. Analysis of …

Targeting Squalene Epoxidase Interrupts Homologous Recombination Via The Er Stress Response And Promotes Radiotherapy Efficacy, Zhipeng Hong, Tao Liu, Lingfeng Wan, Pengyan Fa, Pankaj Kumar, Yanan Cao, Chandra Bhushan Prasad, Zhaojun Qiu, Joseph Liu, Hongbing Wang, Zaibo Li, Qi-En Wang, Peixuan Guo, Deliang Guo, Ayse S. Yilmaz, Lanchun Lu, Ioanna Papandreou, Naduparambil K. Jacob, Chunhong Yan, Qing-Bai She

Pharmacology and Nutritional Sciences Faculty Publications

Over 50% of all patients with cancer are treated with radiotherapy. However, radiotherapy is often insufficient as a monotherapy and requires a nontoxic radiosensitizer. Squalene epoxidase (SQLE) controls cholesterol biosynthesis by converting squalene to 2,3-oxidosqualene. Given that SQLE is frequently overexpressed in human cancer, this study investigated the importance of SQLE in breast cancer and non–small cell lung cancer (NSCLC), two cancers often treated with radiotherapy. SQLE-positive IHC staining was observed in 68% of breast cancer and 56% of NSCLC specimens versus 15% and 25% in normal breast and lung tissue, respectively. Importantly, SQLE expression was an independent predictor of …

Rapid Removal Of Pfoa And Pfos Via Modified Industrial Solid Waste: Mechanisms And Influences Of Water Matrices, Hongyi Wan, Rollie Mills, Kai Qu, James C. Hower, M. Abdul Mottaleb, Dibakar Bhattacharyya, Zhi Xu

Chemical and Materials Engineering Faculty Publications

Emerging perfluoroalkyl and polyfluoroalkyl substances contaminate waters at trace concentrations, thus rapid and selective adsorbents are pivotal to mitigate the consequent energy-intensive and time-consuming issues in remediation. In this study, coal combustion residuals-fly ash was modified (FA-SCA) to overcome the universal trade-off between high adsorption capacity and fast kinetics. FA-SCA presented rapid adsorption (teq = 2 min) of PFOX (perfluorooctanoic acid and perfluorooctanesulfonic acid, collectively), where the dynamic adsorption capacity (qdyn = qm/teq) was 2–3 orders of magnitude higher than that of benchmark activated carbons and anion-exchange resins. Investigated by advanced characterization and kinetic models, the fast kinetics and superior …

Are Soybean Models Ready For Climate Change Food Impact Assessments?, Kritika Kothari, Rafael Battisti, Kenneth J. Boote, Sotirios V. Archontoulis, Adriana Confalone, Julie Constantin, Santiago V. Cuadra, Philippe Debaeke, Babacar Faye, Brian Grant, Gerrit Hoogenboom, Qi Jing, Michael Van Der Laan, Fernando Antônio Macena Da Silva, Fabio R. Marin, Alireza Nehbandani, Claas Nendel, Larry C. Purcell, Budong Qian, Alex C. Ruane, Céline Schoving, Evandro H. F. M. Silva, Ward Smith, Afshin Soltani, Amit Srivastava, Nilson A. Vieira Jr., Stacey Slone, Montserrat Salmerón

Plant and Soil Sciences Faculty Publications

An accurate estimation of crop yield under climate change scenarios is essential to quantify our ability to feed a growing population and develop agronomic adaptations to meet future food demand. A coordinated evaluation of yield simulations from process-based eco-physiological models for climate change impact assessment is still missing for soybean, the most widely grown grain legume and the main source of protein in our food chain. In this first soybean multi-model study, we used ten prominent models capable of simulating soybean yield under varying temperature and atmospheric CO₂ concentration [CO₂] to quantify the uncertainty in soybean yield …

Supportive Neighborhoods, Family Resilience And Flourishing In Childhood And Adolescence, Sheila Barnhart, Molly R. Bode, Michael C. Gearhart, Kathryn Maguire-Jack

Social Work Faculty Publications

Flourishing is linked with health and well-being in childhood and adulthood. This study applied a promotive factors model to examine how neighborhood assets might benefit child and adolescent flourishing by promoting family resilience. Using data from the combined 2018 and 2019 National Survey of Children’s Health, structural equation models tested direct and indirect relationships between neighborhood physical environment, neighborhood social cohesion, family resilience, and flourishing among 18,396 children and 24,817 adolescents. After controlling for multiple covariates that may influence flourishing, the models supported that higher levels of neighborhood social cohesion were directly associated with higher levels of flourishing adolescents, and …

Tumor Suppressor Par-4 Regulates Complement Factor C3 And Obesity, Nathália Araujo, James Sledziona, Sunil K. Noothi, Ravshan Burikhanov, Nikhil Hebbar, Saptadwipa Ganguly, Tripti Shrestha-Bhattarai, Beibei Zhu, Wendy S. Katz, Yi Zhang, Barry S. Taylor, Jinze Liu, Li Chen, Heidi L. Weiss, Daheng He, Chi Wang, Andrew J. Morris, Lisa A. Cassis, Mariana N. Nikolova‑Karakashian, Prabhakara R. Nagareddy, Olle Melander, B. Mark Evers, Phillip A. Kern, Vivek M. Rangnekar

Clinical and Translational Science Faculty Publications

Prostate apoptosis response-4 (Par-4) is a tumor suppressor that induces apoptosis in cancer cells. However, the physiological function of Par-4 remains unknown. Here we show that conventional Par-4 knockout (Par-4^-/-) mice and adipocyte-specific Par-4 knockout (AKO) mice, but not hepatocyte-specific Par-4 knockout mice, are obese with standard chow diet. Par-4^-/- and AKO mice exhibit increased absorption and storage of fat in adipocytes. Mechanistically, Par-4 loss is associated with mdm2 downregulation and activation of p53. We identified complement factor c3 as a p53-regulated gene linked to fat storage in adipocytes. Par-4 re-expression in adipocytes or c3 deletion reversed …

Intensive Versus Standard Treatment Of Hyperglycemia In Acute Ischemic Stroke Patient: A Randomized Clinical Trial Subgroups Analysis, Michael T. Torbey, Qi Pauls, Nina Gentile, Mercedes Falciglia, William Meurer, Creed L. Pettigrew, Valerie L. Durkalski-Mauldin, Thomas Bleck, Askiel Bruno

Neurology Faculty Publications

Background: Benefit from blood glucose (BG) control during acute ischemic stroke may depend on glycemic parameters. We evaluated for associations between the SHINE (Stroke Hyperglycemia Insulin Network Effort) randomized treatment group and the SHINE predefined 90-day functional outcome, within-patient subgroups defined by various glycemic parameters.

Methods: The SHINE Trial randomized 1151 patients within 12 hours with acute ischemic stroke and hyperglycemia to standard (target BG 80-179 mg/dL) or intensive (target BG 80-130 mg/dL) BG control for 72 hours. We predefined 6 glycemic parameters: acute BG level, absence versus presence of diagnosed and undiagnosed diabetes, hemoglobin A1c, glycemic gap …

A Hedonic Analysis Of Factors Impacting The Value Of Planters On The Used Machinery Market, John Allison Jr., Tyler B. Mark, Kenneth H. Burdine, Jordan M. Shockley

Agricultural Economics Faculty Publications

A hedonic model was employed to examine factors that influence the resale price of row crop planters on the used machinery market. Planter sale data from 2016 to 2018 were utilized to conduct the analysis. Results suggested that the primary factors impacting planter resale prices were make, age, condition, planter configuration, row number, and row spacing. As a function of age (depreciation), planter values were generally determined to decrease at a decreasing rate. Finally, it was determined that there was a significant interaction between the variables make and age, suggesting that different planter makes depreciate differently.

Dissociation Of Tau Pathology And Neuronal Hypometabolism Within The Atn Framework Of Alzheimer’S Disease, Michael Tran Duong, Sandhitsu R. Das, Xueying Lyu, Long Xie, Hayley Richardson, Sharon X. Xie, Paul A. Yushkevich, Alzheimer’S Disease Neuroimaging Initiative, David A. Wolk, Ilya M. Nasrallah, Charles D. Smith, Gregory A. Jicha, Peter A. Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Michael W. Weiner, Paul Aisen, Ronald C. Petersen, Clifford R. Jack Jr.

Sanders-Brown Center on Aging Faculty Publications

Alzheimer’s disease (AD) is defined by amyloid (A) and tau (T) pathologies, with T better correlated to neurodegeneration (N). However, T and N have complex regional relationships in part related to non-AD factors that influence N. With machine learning, we assessed heterogeneity in ¹⁸F-flortaucipir vs. ¹⁸F-fluorodeoxyglucose positron emission tomography as markers of T and neuronal hypometabolism (N_M) in 289 symptomatic patients from the Alzheimer’s Disease Neuroimaging Initiative. We identified six T/N_M clusters with differing limbic and cortical patterns. The canonical group was defined as the T/N_M pattern with lowest regression residuals. Groups resilient to …

Differences In Distress Between Rural And Non-Rural Appalachian Breast Cancer Patient / Caregiver Dyads During The First Year Of Treatment, Jordan Tasman, Callie D. Mcadams, Jillian Lloyd, Ashton J. Brooks, Patricia Nola Eugene Roberson

Journal of Appalachian Health

Introduction: Breast cancer patients and their caregivers living in rural Appalachia face substantial health disparities compared to their non-rural Appalachian counterparts. However, there is limited research on how these specific health disparities in rural Appalachian communities may impact patient psychological distress and caregiver strain during the first year of breast cancer treatment.

Purpose: The purpose of the current study was to assess differences in patient psychological distress (depression and anxiety) and caregiver strain between rural non-rural Appalachian breast-cancer-affected dyads (patients and their caregivers) during the first year of treatment.

Methods: A total of 48 Appalachian breast cancer patients (with a …

Building Sustainable Rangeland Management Systems Through A One System Innovative Approach, Benedict C. Irwin, T. A. Ameha, M. Mangano, B. W. Solomon, T. Wood

IGC Proceedings (1977-2023)

Working through a collaborative working partnership between the USAID Feed the Future Resilience in Pastoralist Areas (RiPA)1 program and Land Governance Activity (LGA)2 and selected technical partners, these new rangeland programs aim to build on significant breakthrough successes in rangeland management from their previous lowland programs3. These new lowlands pastoralist development programs have been purposely positioned by USAID to coordinate, collaborate and combine working activities focused on the continued improvement and strengthening of rangeland management systems in the lowlands of Ethiopia. In light of this positioning, it is proposed that the programs work together to build a comprehensive sustainable rangeland …

Sustainable Development And The Transformation Of Female Rural Labor: The Case Of Woman Cattle Ranchers In Uruguay, Virginia Courdin

IGC Proceedings (1977-2023)

Internationally, rural women are considered key to sustainable development. However, in the Uruguayan livestock sector, women’s work is largely unrecognized by public policy makers, causing younger women to migrate, and resulting in the "masculinization" of livestock husbandry. In Uruguay, extensive livestock production (range livestock) analysis has historically ignored the genuinely productive role that women play in rangelands, limiting the visibility of their action to reproductive activities while ignoring their importance in terms of income generation, herd management, networking, strategic planning, etc. Although family production integrates women, their work is often invisible, subsumed within domestic chores or seen as "helping" the …

Ruminant Livestock Production Systems And Imperatives For Sustainable Development, J. W. Smith

IGC Proceedings (1977-2023)

No abstract provided.

Biodiversity Conservation And Sustainable Livelihoods In Rangelands: Trends, Challenges And Opportunities, J. Waithaka

IGC Proceedings (1977-2023)

Rangelands cover about 54% of the earth’s surface and are essential for agricultural and livestock production, environmental protection and the in-situ conservation of genetic resources. Despite providing services that support life on earth, rangelands have been neglected to a large extent when compared to other types of ecosystems. This paper provides an overview of the importance of rangelands in conserving biodiversity and supporting the livelihoods of millions of people globally. Rangelands have lost ecological integrity due to unsustainable anthropogenic land-use changes and impacts. It is estimated that over 80% of Key Biodiversity Areas (KBAs) are either not adequately protected or …

Feasibility Of Organic Certification Of Sheep And Goats Produced In Pastoral Systems In Northern Kenya, F. Von Steimker, H. T. Wario, B. Kaufmann

IGC Proceedings (1977-2023)

In pastoral systems of Kenya, sale of small ruminants is the main regular income source for most households. Although the meat of small ruminants produced in Marsabit county is preferred in the domestic market, no mechanisms are in place that allow for a respective price differentiation. Establishing value chains for labelled sheep and goat meat would be an option to allow pastoralists to profit from their high process and product quality. The aim of the current study is to assess the requirements and feasibility to establish a value chain for labelled products (e.g. origin labelled, organic certified) together with the …

Uses Of Native Plant Species Of A Communal Rangeland Within ‘Sierra De Huautla’ Protected Area, México, E. Cortés-Díaz, T. González-Bonilla, L. López-Aguilar, Pedro A. Martínez-Hernández, A. Hernández-Tapia

IGC Proceedings (1977-2023)

Sustainability of communal rangelands has become a major concern at national and international levels because land use conflicts and associated social conflicts allows for over-utilization of selected species making a high pressure on them and given away their places to species with no use at all becoming lands degraded and unproductive. The objective of the study was to determine floristic composition and native plant uses by local peasants. The range surface is of 4262 ha, belongs to the communal land ‘El Limon’, in Tepalcingo, Morelos, Mexico, and it is within the Natural Reserve Area “Sierra de Huautla”. Native vegetation is …