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Development And Validation Of An Instrument To Measure Teacher Self-Efficacy For Meeting The Needs Of Military-Connected Children, Amy M. O'Neill Jan 2023

Development And Validation Of An Instrument To Measure Teacher Self-Efficacy For Meeting The Needs Of Military-Connected Children, Amy M. O'Neill

Theses and Dissertations--Education Sciences

The average military child changes schools six to nine times before graduating high school. With those moves come significant educational challenges, but there is currently no known instrument designed to measure whether teachers believe they are capable of meeting the needs of this population. The purpose of this study was to develop, pilot, and provide initial psychometric evidence for a scale, the Teacher Self-Efficacy Scale for Military Kids (TSES for MilKids), that measures teacher self-efficacy for meeting the needs of military-connected children. A 19-item instrument was created and distributed to regular education teachers in Grades 1-5 in civilian school districts …


The Protection Of Student Data Privacy In Wisconsin School Board Policies, Curtis Clyde Rees Jan 2023

The Protection Of Student Data Privacy In Wisconsin School Board Policies, Curtis Clyde Rees

Theses and Dissertations--Education Sciences

American schools have increasingly adopted technology resources to fulfill their educational obligations. These tools are for instruction, communication, and storing and analyzing student information. Student data can be directory information, enrollment records, achievement data, and student-created products. This increased utilization began with the passage of No Child Left Behind in 2001, and the COVID-19 pandemic led to more educational technology use of student data. Districts turned to third-party vendors for assistance with data systems and virtual learning resources. Before, during, and after the pandemic, stakeholders were concerned about information security and the students' privacy. School leaders looked to federal regulations …


Doing The Work: Using Questions, Tasks, And Sources To Navigate Teaching Contentious Social Studies In Secondary Classrooms, Bonnie Patrice Lewis Jan 2023

Doing The Work: Using Questions, Tasks, And Sources To Navigate Teaching Contentious Social Studies In Secondary Classrooms, Bonnie Patrice Lewis

Theses and Dissertations--Education Sciences

This explanatory case study examines how two secondary social studies teachers use inquiry-based learning to mitigate the risks of teaching contentious social studies in a charged classroom. Research questions included: 1. How do two in-service secondary teachers use inquiry-based instruction to navigate teaching contentious social studies during charged times? 2. What curricular and pedagogical choices were made by the in-service teachers to navigate risk when designing inquiry-based instruction that features contentious social studies during charged times? 3. What curricular and pedagogical choices were made by the in-service teachers to navigate risk when delivering inquiry-based instruction that features contentious social studies …


Supporting The Covid Freshmen: An Exploratory Study Of The Teaching Aspects That Supported The Executive Functioning Of Undergraduate Freshmen During Covid-19, Jennifer Lynn Pusateri Jan 2023

Supporting The Covid Freshmen: An Exploratory Study Of The Teaching Aspects That Supported The Executive Functioning Of Undergraduate Freshmen During Covid-19, Jennifer Lynn Pusateri

Theses and Dissertations--Education Sciences

Transitioning from high school to higher education is one of the most stressful times in a person’s life. But, for the undergraduate students who were freshmen during the fall of 2020 (in the middle of the COVID-19 pandemic), this predictable stress was compounded by additional stressors related to the pandemic. While there were undoubtedly many teaching factors that made learning more difficult during the pandemic, there were also many aspects of teaching that these freshmen found helpful. This exploratory study of secondary data sought to discover which aspects of teaching were most helpful to the COVID Freshmen (the students who …


Internationalizing The Teacher Education Curriculum Toward Global Competency: Academic Leaders’ Perceptions, Ellie F. G. Holliday Jan 2023

Internationalizing The Teacher Education Curriculum Toward Global Competency: Academic Leaders’ Perceptions, Ellie F. G. Holliday

Theses and Dissertations--Education Sciences

To prepare students for an increasingly interconnected world, P-12 teachers must be trained to infuse intercultural and global perspectives into their teaching practice. However, teacher education programs (TEPs) have been criticized for their lack of global perspectives in the curriculum and have been found to be the least internationalized programs at United States (U.S.) universities. Though university senior international officers (SIOs) play a large role in developing a strategic approach toward curriculum internationalization, there is a paucity of research on their perspectives on this process.

In this explanatory sequential mixed methods study, TEP leaders and SIOs at universities in the …


Principal Leadership Practices At Kentucky High Schools Administering The Pisa For Schools: Leading For Global Competitiveness, Marjorie L. Johnson Jan 2023

Principal Leadership Practices At Kentucky High Schools Administering The Pisa For Schools: Leading For Global Competitiveness, Marjorie L. Johnson

Theses and Dissertations--Education Sciences

Since launching Sputnik in 1957, the United States education system has been trying to climb to the top of the international education rankings. The Organisation for Economic and Co-operative Development (OECD) began analyzing how well school systems prepared students to compete in the global economy in 2000. The OECD uses the Programme for International Student Assessment (PISA). U.S. students rank at or near the OECD averages in reading and science but consistently perform below the OECD average in mathematics. In addition to the PISA, the OECD released the PISA for Schools, which provides PISA data at the school level.

In …


The Thin Line In The Bluegrass Schools: A Quantitative Study On How School Resource Officers Impact A School And District's Use Of Exclusionary Discipline In Kentucky, Mia Morales Jan 2023

The Thin Line In The Bluegrass Schools: A Quantitative Study On How School Resource Officers Impact A School And District's Use Of Exclusionary Discipline In Kentucky, Mia Morales

Theses and Dissertations--Education Sciences

Legislatures across the country have been developing laws and policies to place police officers, also known as School Resource Officers (“SROs”), in schools. A recent piece of legislation in Kentucky, entitled the School Safety and Resiliency Act, requires all school campuses in Kentucky contain at least one SRO. Researchers have found relationships between the presence of SROs and the use of exclusionary discipline, and this research expands on that foundation by looking statewide at school- and district-level variables.

Using a multiple regression model, this research examined the presence of SROs in schools and the ratio of number of SROs to …


The Perceptions And Usage Of The Interactive Video Playposit In A General Chemistry Course, Tracy Gastineau-Stevens Jan 2023

The Perceptions And Usage Of The Interactive Video Playposit In A General Chemistry Course, Tracy Gastineau-Stevens

Theses and Dissertations--Education Sciences

Technology within science, technology, engineering, and mathematics (STEM) classrooms has been a topic of discussion for decades (Reiser, 2001, 2007). With the inclusion of more technologies or digital tools in the classroom has pushed classes towards a blended learning or flipped classroom approach (Atkins 2015; Tayebinik & Puteh, 2013; Williams et al., 2008). One such digital tool that has started gaining traction in the STEM classroom is the interactive video (M. K. Seery, 2013; Smith, 2013). Interactive videos allow students to watch the general lecture material outside of class and work through problems during normal class time (M. K. Seery, …


High School Student Perceptions Of Positive Behavior Interventions And Supports, Candice Conley Jan 2023

High School Student Perceptions Of Positive Behavior Interventions And Supports, Candice Conley

Theses and Dissertations--Education Sciences

This case study examines student voice and their interpretations of the Positive Behavior Interventions and Supports (PBIS) framework used in one Kentucky high school. Qualitative interview data from high school student focus groups was analyzed using grounded theory to develop themes related to PBIS implementation.

Using open and axial coding, themes were developed from common student interpretations of PBIS within focus groups. Participants discussed a variety of positive techniques teachers use inside the classroom and responses to student behavior. Reward systems were discussed, but more importantly students offered suggestions of interventions and supports to offer at school. When asked to …


Developing Pedagogical Content Knowledge As Communal Practice: A Case Study Of Chemistry Graduate Teaching Assistants, Walker Bryan Mask Jan 2023

Developing Pedagogical Content Knowledge As Communal Practice: A Case Study Of Chemistry Graduate Teaching Assistants, Walker Bryan Mask

Theses and Dissertations--Education Sciences

Learning does not only happen during dedicated instructional time, which also applies to learning how to teach. Teachers can reflect on their practice while working to continue to improve and develop their teaching skills. In addition to self-reflection, teachers can also learn from their colleagues to experiment with new practices and take others’ teaching knowledge into their repertoire. Understanding how these two processes function can lead to developments in teacher education and professional development, specifically for initiatives that seek to promote collaboration among teachers. Post-secondary educators in particular can benefit from collaborative and reflective practices to improve their teaching, especially …


A Quantcrit Investigation Of The Discriminatory Practices In Texas Education Funding, Stuart Andrew Keogh Jan 2023

A Quantcrit Investigation Of The Discriminatory Practices In Texas Education Funding, Stuart Andrew Keogh

Theses and Dissertations--Education Sciences

The Texas constitution guarantees citizens a "general diffusion of knowledge" and an "efficient system of public free schools." However, the state has often failed to provide sufficient funding to meet this constitutional mandate. Many school districts, especially those serving low-income or minority communities, have been chronically underfunded. This has led to unequal access to quality education. As a result, there have been numerous lawsuits challenging the constitutionality of Texas's school funding system. Plaintiffs argue that the state has violated the education clause of the constitution by failing to adequately and equitably fund public schools. Despite several legislative attempts at reform, …


Transformative Learning In Teachers’ Family Collaboration With English Learner Families: The Role Of Beliefs, Cultural Competence, And Communities Of Practice, Sara Saberimoghaddam Jan 2023

Transformative Learning In Teachers’ Family Collaboration With English Learner Families: The Role Of Beliefs, Cultural Competence, And Communities Of Practice, Sara Saberimoghaddam

Theses and Dissertations--Education Sciences

Through a multiple case approach, this qualitative research study examined how teachers' beliefs on family collaboration and cultural competence related to their family collaboration practices within Culturally Responsive Instruction. The learning theories of Communities of Practice (Lave &Wenger, 1991) and Transformative Learning (Mezirow, 1978), and Critical Consciousness (Freire, 1979) were used as the lens to analyze the data. Teacher interviews and classroom observations were used as data sources. The study found that teachers’ perception of cultural competence impacted their classroom practices. Teachers who worked hard to intentionally change their cultural competence awareness into family collaboration actions appeared to be more …


Teachers’ Sustained Culturally Responsive Practices Three Years After Participation In Professional Development, Brittany Manion Jan 2023

Teachers’ Sustained Culturally Responsive Practices Three Years After Participation In Professional Development, Brittany Manion

Theses and Dissertations--Education Sciences

Teacher professional development (PD) on culturally responsive practices (CRP) provides teachers the opportunity to increase their knowledge and change their practices to better support students from culturally and linguistically diverse backgrounds. This study sampled from a year-long intensive PD on effective instructional practices for English learners (ELs). Grounded in transformative and situated learning theories, this study was designed to understand teachers’ sustained CRP and their experiences four years after participating in a CRP PD. Several questions were investigated in this study: What CRP do teachers sustain? What are factors and supports related to teachers’ sustained implementation? What challenges do teachers …


Development And Validity Inquiry Of A Rubric For Interdisciplinary Competencies In Occupational Safety And Health In Capstone Projects Of Carerc Program Graduates, Olumuyiwa Moses Desmennu Jan 2023

Development And Validity Inquiry Of A Rubric For Interdisciplinary Competencies In Occupational Safety And Health In Capstone Projects Of Carerc Program Graduates, Olumuyiwa Moses Desmennu

Theses and Dissertations--Education Sciences

Emerging demands in the field of interdisciplinary studies reveal a need for competent professionals who can apply their skills and experience to solving complex tasks of the workplace. This has placed inevitable demands on training institutions to adequately equip graduates to deliver on their mandate. Competency appraisal is an effective way to ensure proficiency in graduates. Meanwhile, transparent and valid rubrics provide opportunities for both students and trainers to continuously assess and evaluate the transfer of necessary skills.

This study focused on evaluating interdisciplinary competencies in Occupational Safety and Health (OSH) in the capstone projects of the CARERC program, a …


Score Equating Between Aeps-2 And Aeps-3 For 0-3 Year Olds, Yuyan Xia Jan 2023

Score Equating Between Aeps-2 And Aeps-3 For 0-3 Year Olds, Yuyan Xia

Theses and Dissertations--Education Sciences

Over the past two decades, the emphasis on educational equity in early childhood education (ECE) and early childhood special education (ECSE) has highlighted the importance of assessment through policies and regulations. Ensuring accurate assessment scores is a fundamental aspect of this trend. The release of the Assessment, Evaluation, and Programming System for Infants and Children, Third Edition (AEPS-3) in December 2021 led to a shift from the Second Edition (AEPS-2) in child development scoring. In order to harmonize the previous and updated assessment versions for children aged 0-3 across six developmental domains, a common item non-equivalent design, featuring fixed parameter …


Survey Development And Validation: Student Self Expectations Of The First-Year College Experience Survey (The Se-Fye Scale), Min Xiao Jan 2023

Survey Development And Validation: Student Self Expectations Of The First-Year College Experience Survey (The Se-Fye Scale), Min Xiao

Theses and Dissertations--Education Sciences

First year at a university is often a transitional stage for students where they have opportunities to grow and develop in various areas and get familiar with a collegiate environment. Understanding what first-year students expect to navigate and succeed in their first year at the university is crucial. Their expectations reflect how well they prepared for university, affecting their behaviors and eventually influencing their intentions to continue higher education. One of the primary purposes of this study was to design a survey to measure student self-expectations of the first-year college experience (the SE-FYE scale) by applying a structured survey development …


Uk College Of Medicine African-American Medical Students' Experience With Faculty Mentoring, Ashlee-Nicole C. Hamilton Jan 2023

Uk College Of Medicine African-American Medical Students' Experience With Faculty Mentoring, Ashlee-Nicole C. Hamilton

Theses and Dissertations--Educational Policy Studies and Evaluation

This research study explored the faculty mentoring experiences of African-American medical students at the University of Kentucky College of Medicine (UK COM). The purpose of the research is to determine benefits and challenges expressed by the African-American students so that UK COM can use the student voices to improve faculty mentoring for this student population. The following broad questions guided the research: 1) What are UK College of Medicine African-American medical students’ experiences with faculty mentoring? 2) What are UK College of Medicine African-American medical students’ experience with faculty mentoring on a satellite regional campus? Specifically, the investigation seeks to …


Minimum High School Graduation Requirements And Teacher Compensation, Allison Johnson Jan 2023

Minimum High School Graduation Requirements And Teacher Compensation, Allison Johnson

Theses and Dissertations--Educational Policy Studies and Evaluation

In the last forty years of educational reform, significant changes have been made to the number and type of high school credits students are required to complete for graduation. As these requirements have changed, the demand for higher-level academic courses has increased while teacher shortages, particularly in high-demand areas such as math and science, have continued to increase. This study uses data from the National Center for Education Statistics (NCES) Student and Staffing Survey to examine the relationship between minimum graduation credit requirements in core subject areas (English, math, science and social sciences) and teacher salaries, both holistically and in …


The Moral Imperative To Include More Women In Leadership Within Institutions Of Higher Education, Kathryn Mattingly Flynn Jan 2023

The Moral Imperative To Include More Women In Leadership Within Institutions Of Higher Education, Kathryn Mattingly Flynn

Theses and Dissertations--Educational Policy Studies and Evaluation

In higher education, women’s trajectory into leadership positions is not equitable to men’s. The concerns with the scarcity of women in leadership positions, specifically deans, provosts, presidents, and board members, involve varying levels of gender biases, norms, and stereotypes, as well as expectations of representation. Gender biases and stereotypes remain ingrained in American societal structures and result in immoral consequences, injustice for colleges and universities, and diminished happiness of the participants within them. I will use philosophical inquiry to argue that greater representation of women in the leadership of higher education would lead to morally better outcomes for institutions and …


Wha Up Bruh, You Good: A Critical Analysis Of Mentoring Programs For African American Males In Community College, Taran Landell Mczee Jan 2023

Wha Up Bruh, You Good: A Critical Analysis Of Mentoring Programs For African American Males In Community College, Taran Landell Mczee

Theses and Dissertations--Educational Policy Studies and Evaluation

This qualitative case study used a phenomenological research approach to explore the lived experiences of African American male community college students who participate in mentoring programs. Mentoring programs for African American males in higher education have been implemented to help improve retention, academic performance in the classroom, sense of self, intention to complete, and graduation rates (LaVant et al., 1997). Critical race theory (CRT) informed the use of qualitative interview methods to represent the lived experiences of the participants and to elevate the knowledge of young African American men in research on higher education mentoring programs. Research participants were 8 …


An Exploration Of Athlete Thoughts And Perceptions Of Cohesion In Coacting Sports, Jared Scott Hrabcak Jan 2023

An Exploration Of Athlete Thoughts And Perceptions Of Cohesion In Coacting Sports, Jared Scott Hrabcak

Theses and Dissertations--Kinesiology and Health Promotion

Cohesion is a central element in group dynamics that contributes to a team’s functioning and performance. Most of the cohesion research to date has focused on the dynamic within interacting sport teams (i.e., football, basketball, soccer) but has looked past coacting teams (i.e., golf, tennis, cross-country running). While interacting sports command worldwide popularity, a significant portion of student athletes compete in coacting sports and represent the bulk of NCAA affiliated participants on the world stage at the Olympics. Thus, with such status on the world stage of competition, the investigation of coacting sports is justified. Therefore, the purpose of this …


Food Insecurity On College Campuses: Addressing The Issue Through A Student-Centered Perspective, Thomas Ard Jan 2023

Food Insecurity On College Campuses: Addressing The Issue Through A Student-Centered Perspective, Thomas Ard

Theses and Dissertations--Kinesiology and Health Promotion

Research indicates food insecurity (FI) has become a consistent challenge for college students. However, more is needed regarding the students' lived experiences of food insecurity following the COVID-19 pandemic. Universities play a vital role in assisting students with food insecurity through food assistance programs, on-campus resources, and financial help, which impacts their physiological needs and academic performance. A better understanding of what influences students' perceptions and decisions about whether to engage in these resources is essential.

This dissertation's purpose was to explore how college students living with food insecurity experience engaging in food assistance programs (FAP). The study used a …


A Statewide Network’S Impact On School Leaders’ Self-Efficacy For Transformational School Change, Karen Perry Jan 2023

A Statewide Network’S Impact On School Leaders’ Self-Efficacy For Transformational School Change, Karen Perry

Theses and Dissertations--Curriculum and Instruction

Changing educational practice is widely understood to be a challenging endeavor, even for experienced school leaders. Much of the research on school networks focuses on building teacher capacity for improving student performance, but less evidence exists relating to increasing school leaders’ self-efficacy, specifically for the purpose of transformational school change. Building on the body of research of school networks and leaders’ self-efficacy, this mixed methods participatory action research study investigates how a network, facilitated by university faculty, impacts the leadership self-efficacy of high school principals for the purpose of leading transformational school change. Self- efficacy is both malleable and essential …


The Centrality Of Claim-Making In The Social Studies Classroom: Teaching For Claim-Making With The Persuasive Claim Framework, Ryan Anders Lewis Jan 2023

The Centrality Of Claim-Making In The Social Studies Classroom: Teaching For Claim-Making With The Persuasive Claim Framework, Ryan Anders Lewis

Theses and Dissertations--Curriculum and Instruction

This dissertation includes three articles that focus on the importance of claim-making and argumentative writing in social studies classrooms. Each article highlights various aspects of the claim-making process by introducing ways for teachers to help students write better claims, highlighting the importance of claim-making within the extant social studies literature, and analyzing the results of centering the claim-making process in a preservice teaching methods program.

Article One, “What’s in a Claim: A Framework for Helping Students Write Persuasive Claims?” (2021), is an article written for practicing teachers. As part of a larger discussion on the challenges of implementing the dimensions …


Transplanted Appalachians’ Perspectives Of Culturally Relevant Topics/Texts And How These Topics/Texts Aid In Their Reading Comprehension, Kathryn E. H. Smith Jan 2023

Transplanted Appalachians’ Perspectives Of Culturally Relevant Topics/Texts And How These Topics/Texts Aid In Their Reading Comprehension, Kathryn E. H. Smith

Theses and Dissertations--Curriculum and Instruction

The purpose of this research study was to understand Transplanted Appalachians’ perspectives of culturally relevant topics/texts and how these topics/texts aid in their reading comprehension. This culturally relevant study was framed using Vygotsky’s (1978) sociocultural theory, Barton and Hamilton’s (1998) literacy as a social practice, and Rosenblatt’s (1994) transactional theory. Research participants included five transplanted Appalachian adults from the Central Appalachian Region. The research methods included one introductory interview, four think-alouds, four post think-aloud interviews, and four Cultural Relevance Rubrics. Results from the data sources revealed the participants strongly related to six cultural themes including: community, authentic Appalachian experiences (e.g., …


Determining Kinetic Parameters Of Cellulose And Lignin Pyrolysis By Gaussian Process Regression (Gpr) Method, Pichayaporn Viriya-Amornkij, Kazunori Kuwana Dec 2022

Determining Kinetic Parameters Of Cellulose And Lignin Pyrolysis By Gaussian Process Regression (Gpr) Method, Pichayaporn Viriya-Amornkij, Kazunori Kuwana

Progress in Scale Modeling, an International Journal

The ignition and flame-spread processes in the forest and urban fires involve the pyrolysis reactions of biomass materials. One of the most common methods for estimating the fire performance of a material is the evaluation of kinetic parameters, i.e., activation energy (𝐸), pre-exponential factor (𝐴), and reaction model (𝑓(𝛼)), from thermogravimetric analysis (TG) data. Typically, 𝐸 is estimated based on an Arrhenius-type equation such as Kissinger, Kissinger-Akahira-Sunose (KAS), and Friedman equations. Then, its value is adjusted along with other parameters by assuming a reaction model, e.g., the 𝑛-order model. This study proposes a Gaussian process regression (GPR) method to determine …


Surficial Geologic Map Of The Big Clifty 7.5-Minute Quadrangle, Kentucky, Maxwell L. Hammond Iii, Antonia E. Bottoms, Ann Hislop, Matthew Massey, Michele Mchugh, Emily Morris Dec 2022

Surficial Geologic Map Of The Big Clifty 7.5-Minute Quadrangle, Kentucky, Maxwell L. Hammond Iii, Antonia E. Bottoms, Ann Hislop, Matthew Massey, Michele Mchugh, Emily Morris

Contract Reports--KGS

The Big Clifty 7.5-minute quadrangle is located south of Louisville and west of Elizabethtown along the boundary between Hardin and Grayson Counties. The quadrangle lies within the Mammoth Cave plateau of the Mississippian Plateau physiographic region (McDowell, 1986). Topography is characterized by a low relief plain sitting at elevations between 650 to 850 ft above sea level, which is dissected and incised by Rough River, Meeting Creek, Clifty Creek, and their tributaries to below 500 ft. Swadley (1962) mapped the bedrock geology of the quadrangle, which was later digitized by Conley (2002). Mississippian bedrock is exposed throughout the quadrangle and …


An Exploration Of Service Needs And Preferences Of Dementia Caregivers In Kentucky, Heehyul Moon, Sunshine Rote, Allison Kacmar, Amy Kostelic, Bari Lewis Dec 2022

An Exploration Of Service Needs And Preferences Of Dementia Caregivers In Kentucky, Heehyul Moon, Sunshine Rote, Allison Kacmar, Amy Kostelic, Bari Lewis

Family Sciences Faculty Publications

As Americans live longer, the prevalence of Alzheimer’s disease and related dementias will increase. Caregivers are critical to the care and life quality of people with dementia. Yet, dementia caregivers are at increased risk for health issues, social isolation, and financial challenges. To help educators with the University of Kentucky Cooperative Extension Service work with their local Alzheimer’s Association and the University of Louisville to better support dementia families, we explored caregiver needs and service utilization using an online survey. Our findings highlighted the need for counseling/support, care management skills, resource education, self-care strategies, and legal services. Extension Service Educators …


Phase I Activities Of The Earth Mapping Resources Initiative (Earth Mri) In The Western Kentucky Fluorspar District, Georgina Lukoczki, Craig Dietsch, John B. Hickman, Emily Morris, Douglas C. Curl, Carrie Pulliam, Stephanie Vicroy, William M. Andrews Jr. Dec 2022

Phase I Activities Of The Earth Mapping Resources Initiative (Earth Mri) In The Western Kentucky Fluorspar District, Georgina Lukoczki, Craig Dietsch, John B. Hickman, Emily Morris, Douglas C. Curl, Carrie Pulliam, Stephanie Vicroy, William M. Andrews Jr.

Report of Investigations--KGS

The Western Kentucky Fluorspar District (WKFD), which comprises the Kentucky portion of the Illinois–Kentucky Fluorspar District, is well known for the occurrence of strategically important critical mineral resources, such as fluorite (fluorspar) and rare earth elements (REEs). Due to technological advances, demand has increased for critical minerals used in cell phones, magnets in wind turbines, batteries for electric vehicles, smart weapons, and other devices and systems. The overall objective of the Earth Mapping Resources Initiative (Earth MRI) program, directed by the U.S. Geological Survey (USGS), is to gather information that will help better understand the distribution of critical minerals in …


Evaluation Of Blood-Based, Extracellular Vesicles As Biomarkers For Aging-Related Tdp-43 Pathology, Charisse N. Winston, Sonal Sukreet, Haley Lynch, Virginia M. -Y. Lee, Donna M. Wilcock, Peter T. Nelson, Robert A. Rissman Dec 2022

Evaluation Of Blood-Based, Extracellular Vesicles As Biomarkers For Aging-Related Tdp-43 Pathology, Charisse N. Winston, Sonal Sukreet, Haley Lynch, Virginia M. -Y. Lee, Donna M. Wilcock, Peter T. Nelson, Robert A. Rissman

Neurology Faculty Publications

Introduction: Limbic predominant age related TDP-43 encephalopathy neuropathological change (LATE-NC) is a recently characterized brain disease that mimics Alzheimer’s disease (AD) clinically. To date, LATE-NC is difficult to diagnose antemortem using clinical information or biomarkers. Recent studies suggest concentrations of extracellular vesicle (EVs) protein cargo derived from neuronal and glial cells may serve as useful diagnostic biomarkers for AD and other neurodegenerative diseases.

Methods: TDP-43 was evaluated in neuronal (NDEVs), astrocyte (ADEVs), and microglial derived extracellular vesicles (MDEVs). EV preparations were isolated from the plasma of research subjects with autopsy-confirmed diagnoses, including many with LATE (n = 22). …