Digital Commons Network^™

Body Mass Index Has No Impact On Complications And Mortality For Patients With Stage Iv Pancreatic Ductal Adenocarcinoma, Ren Bryant, Hannah Darnell, Megan Hall, Kelsey N. Karnik, Kristen J. Mcquerry, Ruben R. Plentz

Biostatistics Faculty Publications

Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of United States (USA) cancer death. Overweight and obesity developing into a growing global medical and socio-economic problem, affecting approximately 42% of adults in the USA population. The aim of our analysis was to evaluate the influence of overweight and obesity on complications and clinical outcome in patients with stage IV PDAC.

Methods: We retrospectively reviewed electronic health records of patients diagnosed with stage IV PDAC (n=162) who followed with the University of Kentucky from January 2017–October 2024. Comparisons were based on the body mass index (BMI): low BMI …

Kentucky Space Futures: Defining The Driving And Limiting Factors Of Growth In The State Aerospace Industry, Ashley M. Grospitch, Isabella A. Sibold

MPA/MPP/MPFM Capstone Projects

Kentucky’s aerospace industry has quietly become one of the state’s most significant economic drivers, generating almost $19 billion in exports in 2024 and ranking third nationally in aerospace exports in 2023 (Mattingly, 2025; Babbage & Hartsough, 2024). Despite this, Kentucky remains largely invisible as an aerospace state, both to Kentuckians and national audiences. This work was conducted on behalf of our client, Kentucky Space Futures, to identify the factors shaping the growth of Kentucky’s aerospace industry, including its driving and limiting factors, and provide actionable guidance for policymakers and industry leaders.

Using a qualitative research design, this study triangulated findings …

Kentucky Is Working: An Examination Of Higher-Than-Expected Labor Force Participation Rates In Kentucky, Grace E. Coleman, Gabriel M. Kalla, Joseph S. Matthews

MPA/MPP/MPFM Capstone Projects

This client-based capstone examines the drivers of higher-than-expected labor force participation rates across five counties in Kentucky, i.e., Kenton, Pendleton, Owen, Taylor, and Monroe counties. Our client, the Kentucky Chamber of Commerce, requested a qualitative analysis of semi-structured interviews with local stakeholders to identify and contextualize factors contributing to the five counties’ overperformance. Our findings suggest that factors such as collaboration and partnership; education and career pathway initiatives; and community champions all play important roles in supporting strong labor force participation. These insights can be used by other counties seeking to strengthen their local workforce.

Federal Housing Policy Influences And Impacts On Urban Municipalities As Seen In The City Of Paterson, New Jersey, Jennifer L. Beggs

MPA/MPP/MPFM Capstone Projects

This paper examines federal affordable housing policy from the early twentieth century to the present, focusing on the City of Paterson, New Jersey. In presenting an overview of policy and decision-making in Paterson, this paper explores how federal policy has aided urban communities that lacked the opportunities afforded to suburban municipalities through FHA mortgage underwriting and single-family homeownership programs, also considering how New Jersey State housing policy has affected the city. Utilizing a case-study methodology and employing extensive archival research, this project examines how federal housing policy structured differential access to homeownership and rental housing in Paterson, and how these …

Functionalization Of Microfiltration Media Towards Catalytic Hydrogenation Of Selected Halo-Organics From Water, Subrajit Bosu, Samuel S. Thompson, Doo Young Kim, Noah D. Meeks, Dibakar Bhattacharyya

Chemical and Materials Engineering Faculty Publications

Contaminated water detoxification remains difficult due to the presence of persistent halo-organic contaminants, such as perfluorooctanoic acid (PFOA) and chlorophenols, which are chemically stable and resist conventional purification methods. Functionalized membrane-based separation and decontamination have garnered immense attention in recent years. Commercially available microfiltration membrane (PVDF) and polymeric non-woven fiber filters (glass and composite) are functionalized with poly(methacrylic acid) (PMAA) that shows outstanding pH-responsive performance and tunable water permeability under ambient conditions perfect for environmental applications. Polymer loading based on weight gain measurements on PMAA–microglass composite fibers (137%) and microglass fibers (116%) confirmed their extent of functionalization, which was significantly …

Jasmonic Acid And Nanoparticle Elicitation Of L. Cardinalis – Differentiating Elicitor Contributions In Nanoparticle Delivery Strategies, Rachel P. Sutherland, Mckenna F. Clinch, Kristen Bruce, D. Trent Rogers, John Littleton, Bert Lynn, Stephen Rankin, Barbara L. Knutson

Chemical and Materials Engineering Faculty Publications

Elicitation is an important strategy for producing plant secondary metabolites, which are responsible for a plant's highly dynamic chemical defense against environmental stressors such as UV light, predators, and pathogens. Elicitation strategies have recently employed nanoparticles as carriers to effectively deliver the elicitation agent through the cell membrane. This study examines the elicitation of secondary metabolites in Lobelia cardinalis hairy root cultures (HRCs) in response to the plant hormone jasmonic acid (JA) and a JA-loaded nanoparticle carrier (mesoporous silica nanoparticles (MSNPs)). Ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) with high resolution mass spectrometry identified 12 m/z features only upregulated in the …

Stochastic Mechanical Mesoscale Modeling Of Cylindrical Cavities In Metallic Foams, Mujan N. Seif, Alexandre Martin, Matthew J. Beck

Chemical and Materials Engineering Faculty Publications

Aluminum foam is a critical component of state-of-the-art micrometeoroid and orbital debris shielding. However, its randomly oriented constituent ligaments create significant variability in properties at different length scales. Previous efforts have thoroughly characterized the statistical implications of micro- to macro-scale-length transitions on the homogenized elastic behavior of damage-free, pre–micrometeroid and orbital debris (MMOD) strike structures. In this work, the properties of the residual material post MMOD impact are assessed by introducing cylindrical cavities representing the damage track. It was observed that configuring the cavity parallel to the through-the-thickness direction transformed a nominally isotropic foam into an anisotropic (transverse isotropic) material, …

Effect Of Protective Mutation On Structure And Dynamics Of Apoe: A Molecular Dynamics Simulation Study, Newton A. Ihoeghian, Usman L. Abass, Ibrahim A. Imam, Qing Shao

Chemical and Materials Engineering Faculty Publications

Apolipoprotein E (APOE) plays a significant role in determining the risk of Alzheimer’s disease (AD). Three mutations—APOE3–R136S, APOE3–V236E, and APOE4–R251G—have been reported to reduce the risk of AD. Unveiling the molecular mechanism behind this reduction could lay a foundation for developing therapeutics for AD. To shed light on this subject, we investigate the mutation-induced variation in structural and dynamic properties of APOE3–R136S, APOE3–V236E, and APOE4–R251G in explicit solvent using molecular dynamics simulations. The APOE2, APOE3, and APOE4 were used as the reference. The analysis unveiled that the three protective mutations may exert protection through different mechanisms. The R215G mutation makes …

Pediatric Chop Chemotherapy Acutely Disrupts Satellite-Cell Dynamics And Blunts Muscle Mass In A Sex-Specific Manner, Jainil Daredia, Marc A. Magaña, Carla M.C. Nascimento, Jaden M. Wells, Nicholas T. Thomas, Yuan Wen, Savannah V. Rauschendorfer, Cory M. Dungan, Michael P. Wiggs

Physiology Faculty Publications

Pediatric cancer survival now exceeds 85% owing, in part, to advances and the use of combination chemotherapy treatments such as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone). Despite its efficacy, CHOP may cause off-target effects during critical pediatric development periods such as impairments of skeletal muscle. We evaluated the acute effects of a CHOP administered to C57Bl/6J mice from postnatal day 28 to 48. CHOP slowed body-weight gain and led to a smaller gastrocnemius fiber cross-sectional area by ~25% in both sexes (n ¼ 11 or 12 males; n ¼ 8 or 9 females). RNA sequencing detected 214 differentially expressed genes …

A Simple Statistical Tool To Correct The Daily Temperature Effect On Dielectric Soil Matric Potential Sensor Readings, Sebastián Bravo Peña, Meindert Commelin, Ole O. Wendroth

Plant and Soil Sciences Faculty Publications

High-resolution time series recorded by soil water dielectric sensors are often affected by other processes. Dielectric soil matric potential sensors, such as the TEROS 21, exhibit temperature sensitivity, resulting in deviations of readings from the true value due to soil temperature fluctuations. However, methods for correcting this effect remain limited. The objective of this study was to create a straightforward, scale-based statistical approach to mitigate the influence of daily temperature oscillations on matric potential dielectric readings. The temperature sensitivity correction function (TSCF) identifies, quantifies, and smooths diurnal fluctuations caused by soil temperature dynamics. We provide a detailed description of the …

Applying Photovoice To Uncover Fundamental Causes Of Health Inequality In Local Health Contexts, Marisa Booty, Madelyne G. Culbertson, Mason Taylor, Dakota Heise, Heather Stone, Katherine Leanne Kommer, Jennifer Gulley, Jeanette Hart, Christina Nentwick, Margaret Mcgladrey

Sociology Faculty Publications

Introduction: Participatory action research methods like Photovoice are uniquely equipped to identify structural determinants of health based on lived experiences of how they influence proximal and distal population health outcomes. This study uses Photovoice data to examine how structural determinants impact community health needs.

Methods: Qualitative thematic analysis used focus group discussion data (25 transcripts) from four Kentucky counties that embedded Photovoice into their local health department community health assessment processes. Coded excerpts were examined for ways in which participants' community health concerns reflected structural issues rather than individual health behaviors.

Results: Participants perceived issues such as houselessness, food insecurity, …

Current And Emerging Therapeutic Strategies For The Treatment Of Duchenne Muscular Dystrophy, Miguel A. Lopez Perez, Noah L. Weisleder

Molecular and Cellular Biochemistry Faculty Publications

Background/Objectives: Duchenne muscular dystrophy (DMD) is a fatal, progressive neuromuscular disorder caused by mutations in the dystrophin gene, leading to the absence of functional dystrophin protein. As the largest gene in the human genome, the DMD locus is highly susceptible to mutations, contributing to a prevalence of approximately 1 in 3800–6300 live male births worldwide. This review aims to provide a comprehensive and critical synthesis of current and emerging therapeutic strategies for DMD.

Methods: We conducted a narrative review of the literature, integrating findings from clinical trials, regulatory approvals, and preclinical studies. We categorized therapeutic approaches into mutation-agnostic and mutation-specific …

Prevalence And Characteristics For Mental Health Disorder Before And After Childhood Cancer Diagnosis—A Statewide Population-Based Study Among Medicaid Beneficiaries, Feitong Lei, Laurie E. Mclouth, Eric B. Durbin, Thomas T. Tucker, John L. Villano, Bin Huang

Internal Medicine Faculty Publications

Introduction: Pediatric cancer patients suffer mental health deficits. Patients who are vulnerable with respect to socioeconomic or other sociodemographic factors may be at heightened risk for worse mental health outcomes during cancer for many reasons including entering treatment with an existing mental health disorder. The purpose of this study was to describe the prevalence and trajectory of mental health before and after a childhood cancer diagnosis in a socio-demographically at-risk sample.

Methods: Data from the Kentucky Cancer Registry was utilized to identify patients aged 19 or under with a first primary childhood cancer diagnosis during 2001–2017. Linking KCR data with …

Disability Studies And Disability Evaluation In Healthcare—Themes And Challenges Moving Forward, Debra A. Harley, Si-Yi Chao

Early Childhood, Special Education, and Counselor Education Faculty Publications

No abstract provided.

Discrimination Distress And Current Combustible And Non-Combustible Tobacco Product Use Among Us Youth, 2023, Meman Diaby, Osayande Agbonlahor, Maggie K. Richardson, Joy L. Hart, Shyanika W. Rose, Delvon T. Mattingly

Markey Cancer Center Faculty Publications

Introduction: Discrimination is the unfair treatment of people based on their identity. Youth who experience discrimination may cope with associated distress by using tobacco products, with amplified health consequences depending on the type of product.

Methods: We used data from the 2023 National Youth Tobacco Survey (n = 22 069) and derived an overall continuous measure from the 15-item Adolescent Discrimination Distress Index, as well as three continuous discrimination distress sub-indices: educational, institutional, and peer (range for each: 0–5). We defined current tobacco use as two outcomes: any past 30-day use of combustible (cigarettes, cigars, hookah, roll- your-own, pipe, bidis) …

Childhood Mental Health And Major Depression In Later Life: A Survival Analysis Across 12 Years, Xiaoling Xiang, Xiafei Wang, Xinyin Zhang, Josephine Abrials

Social Work Faculty Publications

Objectives: This study examined the relationship between childhood mental health conditions and incident major depression in middle-aged and older adults.

Methods: This longitudinal panel study used 12 years of data from 27,220 adults aged 51 and older in the U.S. Health and Retirement Study. Childhood mental health conditions were assessed retrospectively with a question about having a depression, drug/alcohol, or other emotional problem before age 16. Cox regression was used to estimate hazard ratios (HRs).

Results: Childhood mental health conditions were reported by 6.04% of the unweighted sample (n = 1643) and were associated with a more than 2-fold …

Federated Data Engineering And Learning For Edge Intelligence Systems, Afsaneh Mahanipour

Theses and Dissertations--Computer Science

The rapid proliferation of Internet of Things (IoT) devices and cyber–physical systems (CPS) in domains such as smart healthcare, intelligent transportation, and industrial automation has led to unprecedented volumes of heterogeneous data. While advances in deep learning and large-scale foundation models have enabled powerful data-driven decision making, their deployment in real-world distributed environments remains fundamentally constrained by limited computation, communication bandwidth, energy resources, and data privacy requirements. This dissertation addresses these challenges by developing novel federated learning frameworks and efficient federated data-processing pipelines that make large-scale artificial intelligence practical, scalable, and trustworthy in resource-constrained settings. This dissertation identifies data preprocessing …

Multi-Objective Optimization Of Energy Costs And Ev Battery Health In V2g Enabled Homes, Dzifa M. Hodey

Theses and Dissertations--Computer Science

Electric vehicles (EVs) and rooftop solar photovoltaic (PV) systems are increasingly being integrated into residential settings, creating new opportunities for vehicle-to-grid (V2G) and vehicle-to-home (V2H) operations. In these systems, the EV battery functions as a controllable energy storage unit that can charge from the grid or PV and discharge energy to supply household load or export to the grid for a profit. By intelligently scheduling this bidirectional power exchange, households can reduce electricity costs and enhance PV utilization. Realizing these benefits requires optimization strategies that balance cost reduction with EV battery health preservation. However, existing V2G/V2H studies largely emphasize cost …

Toward Efficient And Scalable Scientific Data Management Through Quality-Oriented Data Compression, Pu Jiao

Theses and Dissertations--Computer Science

Scientific simulations and instruments now produce data at rates that overwhelm the storage, memory, and network subsystems of modern high-performance computing (HPC) facilities. Error-bounded lossy compression reduces data movement costs while bounding reconstruction error, yet three barriers limit its adoption in mission-critical workflows: existing compressors cannot guarantee the accuracy of domain-specific quantities of interest (QoIs) derived from compressed data; compression-induced artifacts such as posterization, blocking, and interpolation banding erode user confidence in decompressed fields; and significant compressibility in the quantization index arrays of interpolation-based pipelines remains unexploited. This dissertation addresses all three barriers through four contributions, with the artifact barrier …

Alexander Duals Of Symmetric Simplicial Complexes And Stanley-Reisner Ideals, Ayah Almousa, Kaitlin Bruegge, Martina Juhnke-Kubitzke, Uwe Nagel, Alexandra Pevzner

Mathematics Faculty Publications

Given an ascending chain (I_n)_n∈N of Sym-invariant squarefree monomial ideals, we study the corresponding chain of Alexander duals (I_n^∨)_n∈N. Using a novel combinatorial tool, which we call avoidance up to symmetry, we provide an explicit description of the minimal generating set up to symmetry in terms of the original generators. Combining this result with methods from discrete geometry, this enables us to show that the number of orbit generators of I_n^∨ is given by a polynomial in n for sufficiently large n. The same is true for …

Feasibility Study Of A Screening Decision Tool For Allocating Adults Into Food Is Medicine Programs As An Effective Approach To Target Clinical And Dietary Outcomes Among Rural And Urban Adults, Alison Gustafson, Carolyn Lauckner, Joshua L. Bush, Emily Dimond, Carolina Morales Serrano, Christa Mayfield, Elizabeth T. Anderson Steeves

Dietetics and Human Nutrition Faculty Publications

Objective: Evaluate feasibility (primary), clinical, and cost outcomes (secondary) associated with the use of a screening decision tool for allocating rural and urban adults with hypertension into in a food is medicine (FIM) program.

Design: Participants were allocated to receive either medically tailored meals or grocery prescription (Rx), based on a user-centered designed screening decision tool. Medically tailored meals (MTM) provided 5 meals per week for 12 weeks. The grocery Rx program provided $100 each month for 3 months to purchase food consistent with guidelines for hypertension. Feasibility outcomes included engagement, dose, and program acceptability. Semi-structured interviews were completed with …

Three Essays On Disparities And Outcomes Among Patients With Diabetes, Aiemere O. Oikeh

Theses and Dissertations--Health Services Research (HSR)

The American Diabetes Association (ADA) recommends that patients with diabetes adopt 7 preventive care measures to improve their health outcomes. The recommendations are to check their blood glucose levels daily, undergo biennial hemoglobin A1c tests, undergo dilated eye exams once every 2 years, engage in regular physical activity, check their feet daily, have annual feet examinations performed by a clinician, and receive diabetes self-management education services (DSMES). Marital status has been found to be associated with positive health outcomes; thus, it is ideal to evaluate if there is an association between marital status and diabetes preventive care. The ADA also …

Association Between Perioperative Patient-Reported Outcomes And Upper Extremity Functional Performance In Degenerative Cervical Myelopathy, Harshit Arora, Hassan Darabi, Vishwajeet Singh, Aysha Alsahlawi, Jared T. Wilcox, Francis Farhadi

Neurosurgery Faculty Publications

Background: Degenerative cervical myelopathy (DCM) is caused by chronic compression of the cervical spinal cord. Individuals usually present with a combination of upper extremity dysfunction, imbalance, and bladder dysfunction, which impact overall quality of life. Various questionnaires like mJOA, Nurick, NDI, and DCM-72 have been used for disease stratification. Our study aims to evaluate the clinical correlation between self-reported measures and objective upper extremity assessments and to derive the minimal clinically important difference (MCID) for individuals with DCM.

Methods: A prospective two-center study of consecutive patients diagnosed with DCM was undertaken. A comprehensive assessment of upper extremity functioning including dexterity, …

Associations Between Traumatic Life Events And Substance Use Among Black Men Who Are Incarcerated, Jasmine K. Jester, Brittany Miller-Roenigk, Paris B. Wheeler, Danelle Stevens-Watkins

Educational, School, and Counseling Psychology Faculty Publications

The current study examined associations between traumatic life events, current and lifetime importance of mental health and substance use treatment, and crack cocaine use among 201 Black men who were incarcerated and nearing community reentry. Results indicated age, sexual trauma and lifetime importance of drug treatment were significantly associated with an increased likelihood of crack cocaine use. Substance abuse treatment in correctional settings should consider culturally tailored assessment and treatment for history of unaddressed sexual trauma among Black men who are incarcerated and use crack cocaine.

Effective Deep Learning Architectures For Structured Data Analysis And Generation, Md Atik Ahamed

Theses and Dissertations--Computer Science

The effective utilization of structured data is fundamental to modern machine learning, yet it presents distinct challenges in both predictive analysis and generative modeling. Traditional deep learning architectures, particularly Transformers, often suffer from quadratic computational complexity when processing long sequences. This dissertation addresses these limitations by introducing novel architectures based on State-Space Models (SSMs) and Diffusion Models. In the area of predictive analysis, we focus on overcoming the computational bottlenecks of attention mechanisms for tabular and time-series data. First, we introduce MambaTab, a selective state-space architecture designed for efficient tabular classification. By leveraging the linear complexity of SSMs, MambaTab significantly …

Different Destinations: Clarifying And Addressing Pipeline Problems For Women In Academic Archaeology, Scott R. Hutson, Jaycee Castro, Bruno Athie Teruel

Anthropology Faculty Publications

In STEM fields, women tend to leak out of the pipeline to the professoriate. In archaeology, however, robust databases and chronological control reveal that there is no leakage from earning a PhD to tenure-track positions. Nor is there a leak from assistant professor to associate professor. Nevertheless, men get hired as faculty in PhD programs more often than women. This is important because PhD programs are research-intensive and train future leaders. Furthermore, women PhD students have women as advisers more than often men and report advantages to this arrangement. Yet with fewer women faculty in PhD programs, women mentors are …

A Comparative Policy Analysis Of Lung Cancer, Maternal Mortality, And Obesity, Destiny M. Rucker, Rhonda M. Lawson, Trinity Olmstead

MPA/MPP/MPFM Capstone Projects

Kentucky has significantly poorer outcomes than peer states across key women's health indicators. This capstone focuses on lung cancer, maternal mortality, and obesity to evaluate the structural and policy factors behind these disparities. Using a quantitative comparative research design, the study analyzes secondary data from sources including CDC WONDER, the Behavioral Risk Factor Surveillance System (BRFSS), America’s Health Rankings, and the March of Dimes. Data were analyzed in Excel to create comparative figures, benchmarking Kentucky’s outcomes against the U.S. average and four regional peer states: Tennessee, Indiana, Illinois, and Virginia. These states were chosen for their demographic and geographic similarities …

A Comparative Analysis Of Governance And Financial Frameworks In Public Transit Systems: A Case Study Of Lextran And Peer Transit Agencies, Kelin E. Beattie

MPA/MPP/MPFM Capstone Projects

Public transportation serves as a vital community "lifeline," providing essential mobility for the 45% of Americans without private vehicle access and generating a 5-to-1 economic return on investment. This research investigates a critical fiscal paradox within Lextran, the transit authority for Lexington, Kentucky: despite achieving a cost per passenger trip 22% lower than the national peer average, the agency faces a $25.95 million unfunded capital gap over the current five-year planning horizon. Utilizing a comparative case study methodology, this paper evaluates the "rules of the game"—the hybrid governance and fiscal frameworks—that influence long-term financial sustainability.

The study benchmarks Lextran against …

Allocation And Governance Of Opioid Response Funding In Rural Kentucky: A Case Study Of The Big Sandy Area Development District, Hayley M. Mccarty

MPA/MPP/MPFM Capstone Projects

The opioid epidemic continues to present significant public health, economic, and administrative challenges throughout the United States, with rural Kentucky experiencing some of the nation's highest rates of opioid-related morbidity and mortality.

Effectively responding to this crisis requires not only adequate financial resources but also transparent governance, coordinated implementation, and accountability for how public funds are distributed.

This study examines the allocation, governance, and implementation of opioid response funding within the Big Sandy Area Development District (BSADD), a rural multi-county region in eastern Kentucky. Using a qualitative case study and policy analysis approach, the research evaluates four primary funding sources: …

Should Kentucky Adopt A Formal Statewide Framework To Address The Local Fiscal Effects Of Tax-Exempt Public Universities On Host Communities?, Trina Shields, Catie Baumstark

MPA/MPP/MPFM Capstone Projects

Kentucky’s public universities provide significant educational, economic, and workforce development benefits to the Commonwealth. However, because these institutions are exempt from local property taxes, questions arise about the fiscal effects on the communities that host them. While the benefits generated by universities extend beyond municipal boundaries, the fiscal effects of tax-exempt property are often concentrated within host communities. As universities expand their campuses and acquire additional property, local governments may face increased demands for public services without a corresponding increase in property tax revenue.

This study examines whether Kentucky should adopt a formal statewide framework to address the local fiscal …