Digital Commons Network^™

Establishing A Public Health Surveillance System For The Opioid Crisis: The Experience Of The Healing Communities Study, Bridget Freisthler, Daniel J. Feaster, Charles Knott, Marc Larochelle, John Mccarthy, Svetla Slavova, Sharon L. Walsh, Jennifer Villani

Biostatistics Faculty Publications

Introduction: Efforts to reduce opioid overdose deaths in the United States have been stymied by the lack of timely and standardized population-level data for local, state, and national levels. The U.S. has a strong national need for linking opioid and other drug overdose surveillance data to service utilization data for overdose prevention and treatment to inform resource allocation and response planning.

Methods: We provide insight on the challenges of identifying, obtaining, and harmonizing administrative outcome data across four states using the collective experience from the HEALing Communities Study to test a community-engaged, data-driven, population-level intervention to reduce opioid overdose deaths. …

Curriculum In Pharmacoepidemiology Training Programs: A Cross-Sectional Study To Assess Educational Needs And Alignment With Core Competencies, Amie Goodin, Deborah Layton, Ryan Chung, Vicki Osborne, Chioma Ejekam, Xiaojuan Li, Xuerong Wen, Kristian B. Filion, Luciane Cruz Lopes, Daniela C. Moga

Pharmacy Practice and Science Faculty Publications

Purpose: Pharmacoepidemiology is a key discipline for evidence-based decision-making, yet its educational programs have not been systematically assessed for alignment with international core competencies. Our objectives were to evaluate curricula alignment of pharmacoepidemiology training programs with ISPE-recommended core competency themes and identify key curriculum content development areas.

Methods: The ISPE Core Competencies Workgroup and ISPE leadership developed a curriculum and needs assessment survey, incorporating feedback from global members. The survey was electronically distributed to leaders of pharmacoepidemiology training programs (e.g., department chairs and program directors) using the ISPE contact database, followed by snowball sampling to enhance representation. Institutional respondent characteristics …

Feasibility Of Brief Behavioral Telehealth Interventions For Sleep And Pain In Adults With Chronic Musculoskeletal Orofacial Pain: An Idiographic Clinical Trial, Linda Sangalli, Gabriel Gilmore, Isabel Moreno-Hay, Lauren N. Whitehurst, Anna Alessandri-Bonetti, Ian Andres Boggero

Oral Health Science Faculty Publications

Objective: Brief behavioral interventions targeting pain (Physical Self-Regulation, PSR) or sleep (Brief Behavioral Intervention for Insomnia, BBTI) show promise for interdisciplinary management of chronic pain, though their feasibility with chronic musculoskeletal orofacial pain (MSK-OFP) populations remains underexplored. This pilot study assessed the feasibility of a randomized clinical trial (RCT) of these interventions in a university-affiliated tertiary OFP clinic and explored clinical changes in pain, sleep, and other secondary outcomes.

Methods: Treatment-seeking participants (N=19) with chronic MSK-OFP and insomnia were randomized to three-session PSR or BBTI. At pre- and post-intervention, participants completed questionnaires (assessing pain intensity, insomnia symptomatology, sleep …

Fecal Microbiota Transplantation Modulates Gut Microbiota And Lipid Metabolism To Reduce Diarrhea In Low-Birth-Weight Neonatal Calves, Zhanhe Zhang, Duo You, Donglin Wu, Xintong Li, Yang Jia, David L. Harmon, Ming Xu

Animal and Food Sciences Faculty Publications

This study aimed to elucidate the mechanism by which colonic fecal microbiota transplantation (FMT) improves lipid metabolism in low-birth-weight neonatal calves via modulation of the gut microbial ecosystem. In a completely randomized design, seventy newborn Holstein calves (1 day old, 32.63 ± 3.13 kg BW) were assigned to two groups (35 calves/treatment; 30 females and 5 males per group). A healthy calf was used as a fecal donor. A 10% fecal bacterial suspension was prepared and administered colonically (50 mL, twice daily for 5 days). All calves were fed the same milk replacer and weaned using a step-down protocol at …

The Well-Poised Property And Torus Quotients, Joseph Cummings, Christopher Manon

Mathematics Faculty Publications

An embedded variety is said to be well-poised when the associated initial ideal degenerations coming from points of the tropical variety are reduced and irreducible. Varieties with a well-poised embedding admit a large collection of explicitly constructible Newton-Okounkov bodies. This paper aims to study the well-poised property under torus quotients. Our first result states that GIT quotients of normal well-poised varieties by quasi-tori also have well-poised embeddings. As an application, we show that several Hassett spaces, (Formula presented.), are well-poised under Alexeev’s embedding. Conversely, given an affine T-variety X with polyhedral divisor (Formula presented.) on a well-poised base Y, we …

Molar–Incisor And Generalized Grade C Periodontitis: Distinct Microbiome–Immune Interactions Suggest Divergent Pathogenesis, Camila S. Stolf, Hélvis E. S. Paz, Murilo C. Paraluppi, Manuela Maria Viana Miguel, Mauro P. Santamaria, Mabelle F. Monteiro, Deyvid E. Amgarten, Raquel R. A. Franco, Luciana S. Branco-De-Almeida, Luciana M. Shaddox, Renato C. V. Casarin

Oral Health Practice Faculty Publications

Aim:

Molar-Incisor (PerioC-MIP) and Generalized (PerioC-G) Grade C Periodontitis could have distinctive etiopathogenesis behind their unique clinical patterns. Thus, this study aimed to distinguish these two phenotypes by analyzing the subgingival metagenomic profile and the inflammatory markers levels.

Methods:

In this cross-sectional comparative study, Gingival Crevicular Fluid (GCF) and Subgingival Biofilm (SB) were collected from 18 PerioC-MIP North Americans and 14 periodontally healthy controls (HC) from the same location (HC-MIP) and 20 PerioC-G Brazilians and 20 controls (HC-G). From GCF, immunoenzymatic analysis was performed. SB functional and taxonomic bacterial content was determined using shotgun metagenomics sequencing.

Results:

Taxonomic results showed …

Characterizing Immune Perturbations In Peripheral Blood Following The East Palestine, Ohio Train Derailment, Sheridan B. Wagner, Hami Hemati, Siva Gandhapudi, Timothy J. Hilbert, Candace J. Brancato, Erin N. Haynes, Ilhem Messaoudi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Background: The East Palestine, Ohio, train derailment on February 3rd, 2023, resulted in the exposure of residents and the surrounding area to numerous hazardous chemicals, which included known acute irritants and human carcinogens. Despite evacuation and cleanup, both residents and responders reported high occurrences of symptoms associated with exposure in the months following, such as eye, skin, and respiratory irritation, headaches, and fatigue. The long-term health consequences for residents remain uncertain.

Objective: To assess the potential for immune perturbations resulting from the exposure, we performed a broad investigation of circulating immune cells and mediators from residents of East Palestine, OH, …

Combinatorial Immunotherapy Drives Exhaustion In Tumor Antigen–Specific Cd8+ T Cells Within The Mouse Renal Tumor Microenvironment, Holly R. Stephens, Elizabeth Elkins, Jing Li, Zoey N. Swalley, Henry Nnaemeka Ogbonna, Pia Muri, Zachary Roberts, Francesca R. Dempsey, Md Akkas Ali, Md Hasanul Banna Siam, Richard Kirkman, Jianqing Zhang, Sunil Sudarshan, Daniel J. Tyrrell, Hubert M. Tse, Daniel L. Smith Jr, Lyse A. Norian

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Immunotherapies have greatly improved outcomes for patients with renal cell carcinoma (RCC), yet response rates remain suboptimal and the factors promoting therapy resistance versus sensitivity are incompletely understood. Currently, no preclinical model of orthotopic renal cancer exists that permits evaluation of tumor antigen–specific (TAS) CD8⁺ tumor-infiltrating lymphocytes (TILs). To address this deficiency, we developed a mouse renal cancer model that permits tracking of adoptively transferred TAS CD8⁺ T cells. Renca-LUC tumor cells were transduced to express tumor ERK (tERK), a model antigen expressing a one-amino-acid change from wild-type ERK, resulting in recognition by tERK/H-2K^d-specific DUC Thy1.1 …

Assessing Interdisciplinary Learning And Knowledge: A State-Of-The-Art Review And Heuristic, Kacey Beddoes, Kristi Bartlett

Product Design Faculty Publications

Background – The need for interdisciplinary training is increasingly important, but assessing the effects of interdisciplinary education initiatives remains challenging. One of the leading difficulties is identifying and selecting the best instrument or technique for a given purpose.

Purpose -- To help researchers and educators identify available options and determine the best options for their purposes, we conducted a literature review and created a heuristic table of available techniques. Our review addresses the questions: 1) What domain-general techniques and instruments exist for assessing interdisciplinary learning or knowledge? 2) What research scenarios, populations, and questions are each technique or instrument most …

The Transport Of New Make Spirits Through American White Oak, Taylor E. Scott, Jarrad Gollihue, Michael P. Sama, Michael Shaffer, Brad J. Berron

Biosystems and Agricultural Engineering Faculty Publications

Why was the work done: The reduction of maturation loss is a significant opportunity for increased revenue in aged spirits and varies through several factors. This work aims to better understand maturation loss by isolating and measuring spirit flow through wood.

How was the work done: Bourbon stave disks were fabricated by computer numeric control milling and loaded into a sealed module consisting of flanges holding the stave disk over a liquid filled pipe. The modules were filled with new make spirit at 50, 62.5 or 70% ABV, with either liquid or vapour contact with the stave disk. Further, the …

“Oh, You’Ve Come To Visit The Yard?”: Phenotypic Capital, Intragroup Marginalization, And The Gated Sanctuary In Black Lgbtq+ Communities, Keith J. Watts, Shawndaya S. Thrasher, Nicole Campbell, Laneshia Conner, Julian K. Glover, Janet K. Otachi, Dekeitra Griffin

Social Work Faculty Publications

Identity-based communities that share common characteristics, beliefs, and experiences (e.g., Black LGBTQ+ communities) have historically been conceptualized as protective bubbles that buffer Black LGBTQ+ individuals against the deleterious effects of systemic racism and cisheterosexism. However, this monolithic narrative often masks the internal power dynamics that divide belonging. This study explores the exclusionary dynamics embedded within these safe spaces, examining how internal hierarchies of skin tone, socioeconomic status, and gender performance function as proximal stressors. Guided by a critical constructivist paradigm, this study utilized Reflexive Thematic Analysis to analyze open-ended survey responses from 74 Black LGBTQ+ adults. Data were drawn from …

Assessment Of Hearing Health Among Adults In Rural Health Clinics, Mit A. Patel, David Adkins, Laura Bellnier, Anthony Mahairas, Matthew L. Bush

Otolaryngology--Head & Neck Surgery Faculty Publications

Objective: Hearing loss (HL) negatively impacts all aspects of health, yet poor access to hearing healthcare (HHC) among adults is a pervasive public health problem. The inaccessibility of HHC is amplified in rural adults. Rural health clinics (RHC) are a critical healthcare system tasked with improving health in rural communities and the objective of this study is to assess the prevalence of HL and the utilization of HHC within RHCs.

Methods: Using cross-sectional study design, adults were recruited from 10 RHC throughout rural Kentucky, mostly within Appalachia. The primary outcomes were (1) presence of HL on screening and (2) history …

Effects Of Constant Time Delay Using Multiple Acquisition Exemplars On The Generalization Of Self-Instruction To Complete Vocational Tasks For High School Students With Intellectual Disability, Anna Norby

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

This study presents findings from a multiple probe design that evaluated the effects of constant time delay with multiple acquisition exemplars on the acquisition and generalization of self-instruction to complete vocational tasks for high school students with intellectual disability. The research included three high school students with intellectual disability, and data were analyzed across baseline, intervention, and generalization conditions. Instruction targeted the use of self-instruction procedures embedded within vocational tasks, with multiple exemplars incorporated during acquisition to promote stimulus generalization. Participants were screened using a set of pre-arranged vocational tasks to identify existing skill levels and determine appropriate instructional targets, …

Evaluating Dosage Within A Rapid Caregiver Coaching Model, Emma L. Lovell

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

Rapid caregiver coaching models are designed to increase caregiver implementation of naturalistic language strategies while prioritizing feasibility for both families and providers. Participants of the current study were caregivers with young children (ages 1-4) with expressive language delays and autism risk or diagnosis. The current study took place in families’ homes and examined whether a predetermined number of brief coaching and feedback cycles was sufficient to produce clinically meaningful improvements in caregiver strategy use. Target behaviors for caregivers included play-based imitation and expansion, responsive language input, and structured teaching episodes designed to expand child communication. Results were variable but demonstrated …

A Uniform Analysis Of Gas-Phase Metallicity Evolution With 1–3 Gyr Time Sampling Over The Past 12 Gyr, Shweta Jain, Ryan L. Sanders, Ali Ahmad Khostova, Tucker Jones, Alice E. Shapley, Naveen Reddy, Alex M. Garcia, Paul Torrey, Alison L. Coil

Physics and Astronomy Faculty Publications

We present a systematic investigation of the evolution of the mass–metallicity relation (MZR) and fundamental metallicity relation (FMR) using uniform metallicity diagnostics across redshifts z ∼ 0 to z ∼ 3.3. We present new Keck/Deep Imaging Multi-Object Spectrograph measurements of the [O II]λλ3726, 3729 emission line doublet for star-forming galaxies at z ∼ 1.5 with existing measurements of redder rest-optical lines from the MOSFIRE Deep Evolution Field survey. These new observations enable uniform estimation of the gas-phase oxygen abundance using ratios of the [O II], Hβ, and [O III] lines for mass-binned samples of star-forming galaxies …

Energy Levels Of Multiscale Bound States From Qed Energy-Momentum Trace, Michael I. Eides, Vladimir A. Yerokhin

Physics and Astronomy Faculty Publications

Energy levels of quantum electrodynamics (QED) bound states, which depend on a number of independent mass parameters, can be calculated as matrix elements of the QED energy-momentum tensor trace. As an example of such system we consider muonic hydrogen. The leading one-loop corrections to its energy levels depend on the electron and muon masses. These corrections are calculated as matrix elements of the energy-momentum tensor trace. Respective one-loop trace diagrams are different from the standard Lamb shift diagrams. We explain analytically and diagrammatically why two different sets of diagrams lead to the same results. Similar relationships should also hold beyond …

Cosmos Spectroscopic Redshift Compilation (First Data Release), Ali Ahmad Khostovan, Jeyhan S. Kartaltepe, Mara Salvato, Olivier Ilbert, Caitlin M. Casey, Hiddo Algera, Jacqueline Antwi-Danso, Andrew Battisti, Malte Brinch, Marcella Brusa, Antonello Calabrò, Peter L. Capak, Nima Chartab, Olivia R. Cooper, Isa G. Cox, Behnam Darvish, Nicole E. Drakos, Andreas L. Faisst, Matthew R. George, Ghassem Gozaliasl, Santosh Harish, Günther Hasinger, Hossein Hatamnia, Angela Iovino, Shuowen Jin, Daichi Kashino, Anton M. Koekemoer, Ronaldo Laishram, Khee Gan Lee, Jitrapon Lertprasertpong, Simon J. Lilly, Daizhong Liu

Physics and Astronomy Faculty Publications

We present the COSMOS Spectroscopic Redshift Compilation encompassing ∼20 yr of spectroscopic redshifts within a 10 deg² area centered on the 2 deg² COSMOS legacy field. This compilation contains 487,666 redshifts of 266,284 unique objects from 138 individual programs up to z ∼ 8 with median stellar mass ∼10^8.4-10¹⁰ M_⊙ (redshift dependent). Rest-frame NUVrJ colors and star formation rate-stellar mass correlations show that the compilation primarily contains low-to-intermediate-mass star-forming and massive, quiescent galaxies at z < 1.25 and mostly low-mass bursty star-forming galaxies at z > 2. Sources in the compilation cover a diverse range of environments, including protoclusters such as “Hyperion.” The full compilation …

The Aurora Survey, Danielle A. Berg, Ryan L. Sanders, Alice E. Shapley, Michael W. Topping, Naveen A. Reddy, Evan D. Skillman, Erik Aver, Fergus Cullen, Callum T. Donnan, James S. Dunlop, Tucker Jones, Ali Ahmad Khostovan, Derek J. Mcleod, Desika Narayanan, Pascal A. Oesch, Anthony J. Pahl, Max Pettini, N. M.Förster Schreiber, Daniel P. Stark

Physics and Astronomy Faculty Publications

We present the first robust helium (He) abundance measurements in star-forming galaxies at redshifts 1.6 ≲ z ≲ 3.3 using deep, moderate-resolution JWST/NIRSpec spectroscopy from the AURORA survey. We establish a high-z He sample consisting of 20 galaxies with multiple high-signal-to-noise-ratio (>5σ) He i emission-line detections, including the critical near-infrared λ10833 line. This is the first study at high redshift leveraging λ10833 to break degeneracies between temperature, electron density, optical depth, and He⁺/H⁺, enabling reliable He abundance determinations in the early Universe. We use a custom Markov Chain Monte Carlo framework incorporating direct-method electron temperature …

The Aurora Survey, Anthony J. Pahl, Alice Shapley, Naveen A. Reddy, Ryan Sanders, Michael W. Topping, Danielle A. Berg, Callum T. Donnan, James S. Dunlop, Richard S. Ellis, N. M. Förster Schreiber, K. Glazebrook, Derek J. Mcleod, Max Pettini, Daniel Schaerer

Physics and Astronomy Faculty Publications

We present ionizing photon production efficiencies (ξ_ion) for 63 z = 1.5–6.9 star-forming galaxies using precise nebular dust attenuation corrections from the JWST Assembly of Ultradeep Rest-optical Observations Revealing Astrophysics (AURORA) survey. A subset of objects within AURORA have individually determined nebular dust attenuation curves, which vary significantly in shape and normalization, resulting in reduced systematic uncertainty when constraining the total attenuation of Hα luminosity, and thus the intrinsic ionizing output within our sample. We find evidence for positive correlations between ξ_ion and redshift, equivalent width of [O iii] λ5007, and O32 = [O iii] λ5007/[O ii] …

Cooperative Charge Ordering Signature Of Trimer Molecules In Infinite-Layer Cacoo2, J. S. Lee, W. J. Kim, A. Khandelwal, K. T. Ko, H. Lee, C. T. Kuo, S. Song, C. Song, D. Jang, H. Choi, G. Park, S. Y. Park, G. Kang, H. Jang, P. Abdollahi, A. Seo, C. C. Kao, H. Y. Hwang

Physics and Astronomy Faculty Publications

The infinite-layer compound CaCoO₂ provides a compelling platform to explore how local orbital distortions evolve into collective electronic order. Using resonant soft x-ray scattering (RSXS) and its time-resolved counterpart (tr-RSXS), we reveal a cooperative coupling between two intertwined orders at the same in-plane wave vector, q≈(1/4,1/4,0), comprising a quasi-two-dimensional orbital order associated with the distorted Co(1) sites and a quasi-three-dimensional trimerlike charge order stabilized through Co-O-Ca hybridization. The charge-sensitive component exhibits a uniform relaxation time of ∼400 fs (391±5 fs) across multiple Co resonances, evidencing a collective charge response. A comparable timescale observed in the orbital order associated with …

The Rise Of Ionized Gas Filaments In Early-Type Galaxies, Ryan Eskenasy, Valeria Olivares, Yuanyuan Su

Physics and Astronomy Faculty Publications

Multiphase filamentary nebulae are ubiquitous in the brightest cluster galaxies (BCGs) of cool-core clusters, providing insight into baryon cycling and the feeding and feedback of supermassive black holes. However, BCGs account for less than 1% of all early-type galaxies (ETGs). To broaden our understanding of how multiphase filamentary nebulae form in ETGs and connect to the greater picture of galaxy evolution, it is crucial to explore ETGs that are outside of the dense centers of galaxy clusters or groups. We present VLT-MUSE IFU observations of 126 nearby non-central ETGs, detecting warm ionized gas in 62 of them. 35/62 host rotating …

Enhancing Team Science By Training Collaborative Biostatisticians To Have A Strong Statistical Voice, Gina-Maria Pomann, Steven C. Grambow, Marissa C. Ashner, Bibhas Chakraborty, Nan Liu, Megan L. Neely, Sarah Peskoe, Lacey Rende, Emily Slade, Tracy Truong, Lexie Zidanyue Yang, Greg P. Samsa, Jesse D. Troy

Biostatistics Faculty Publications

Strong statistical voice is defined as the ability to advocate and negotiate for good and ethical statistical practices, including integrating and resolving differing scientific approaches. This skill is crucial for biostatisticians who work on biomedical research teams, as it ensures the integrity and accuracy of statistical analyses and fosters productive collaborations with non-statisticians. Despite its importance, new graduates often lack targeted training opportunities. This manuscript presents a scalable training approach through the development of online videos. Preliminary didactic materials focused on two key applications: providing written comments on manuscripts and engaging in study design discussions. To evaluate this training approach, …

Co-Encapsulation Of Microalgae Haematococcus Pluvialis And Lactic Acid Bacteria Lacticaseibacillus Casei Via Filamentous Fungi Scaffolds Improved Probiotic Viability In Simulated Gastro-Intestinal Conditions, Suvro Talukdar, Tyler J. Barzee

Biosystems and Agricultural Engineering Faculty Publications

Fungal-assisted cell immobilization has emerged as a promising approach for food, energy and environmental applications, utilizing the hyphal network of filamentous fungi to encapsulate microorganisms. Co-encapsulation of multiple microorganisms within fungal pellets enables the development of food delivery systems that combine complementary functional and nutritional properties, including enhanced probiotic protection and delivery of bioactive compounds. This study used edible filamentous fungus Aspergillus awamori to encapsulate Haematococcus pluvialis microalgae and Lacticaseibacillus casei lactic acid bacteria (LAB) for probiotic delivery. Both active and heat-deactivated pellets successfully co-encapsulated microalgae and LAB, although low shear conditions were required for inactive fungal states. Under in-vitro …

Exploring Relational Farming Futures For Responsible Innovation In Precision Agriculture Through Q-Method And Speculative Design, Bhavna Joshi, Maaz Gardezi, Edward Prutzer, Awais Hameed Khan, Asim Zia, Benjamin E. K. Ryan, Ali Dadkhah, Donna M. Rizzo, John T. Mcmaine, David Clay

Biosystems and Agricultural Engineering Faculty Publications

This article draws on concepts of speculative design and responsible innovation to examine the possible impacts of data-driven precision agriculture on farmers and farm work. We use an innovative mixed-method approach to research design. Using artistic depiction of futures of precision agriculture in design workshop and in-depth semistructured interviews conducted with the farmers in Vermont and South Dakota, we explain how farmers perceive different futures of precision agriculture. Specifically, in our design workshop, we combined visual arts and social science methods, namely Q-method, to explore existing and new relationships between humans, technologies, and environment in the design, deployment, and use …

Temporal Evolution Of Brain Inflammation In The Bilateral Common Carotid Artery Stenosis Model Of Chronic Cerebral Hypoperfusion, Makayla F. Cox, Jill M. Roberts, Ryan K. Shahidehpour, David L. Dornbos Iii, Adam D. Bachstetter

Neuroscience Faculty Publications

Chronic cerebral hypoperfusion is a major contributor to vascular cognitive impairment and dementia, primarily through its disruption of white matter integrity and promotion of neuroinflammatory cascades. The bilateral common carotid artery stenosis (BCAS) model has emerged as the predominant experimental approach for studying the effects of chronic cerebral hypoperfusion, particularly in aging-relevant contexts. This review synthesizes current knowledge of inflammatory responses in the BCAS model, with an emphasis on their temporal progression and functional consequences. We begin by outlining the clinical burden of hypoperfusion, the rationale for BCAS, and the hemodynamic phases it produces. We then examine early neurovascular unit …

Endocranial Morphological Affinities Of The Early Holocene Individuals From Lagoa Santa And Implications For The Peopling Of The Americas, María Clara López-Sosa, Hugo Reyes-Centeno, Lumila Paula Menéndez, Rodrigo Elias Oliveira, Claudio Campi De Castro, André Strauss

Anthropology Faculty Publications

The ectocranial morphology of early Holocene humans from Lagoa Santa, Brazil has been described as exhibiting a ‘Paleoamerican’ form with affinities to African and Australasian individuals, in contrast to past and present Native Americans, who predominantly exhibit ‘Amerindian’ form. While this interpretation remains disputed, its led to the ‘Two Main Biological Components Model’, which proposes separate dispersals from Asia into the Americas. This study aims to assess whether the endocranial morphology of Lagoa Santa individuals similarly reflects these affinities. For this study, the overall endocranial morphology, as well as the temporal bones of the crania of twenty individuals from Lagoa …

Factors Associated With Opioid-Involved Overdose: Descriptive Data From A Randomized Controlled Trial Evaluating Extended-Release Buprenorphine For Perinatal Opioid Use Disorder, Sara M. Witcraft, Leah Holcomb, Yingjia Wei, Gerald Cochran, John T. Winhusen, Michelle R. Lofwall, Peter R. Martin, Jessica L. Young, Jessica Spinali, Constance Guille

Center on Drug and Alcohol Research Faculty Publications

Background: Opioid use disorder (OUD) during pregnancy is a leading contributor to peripartum morbidity and mortality, with overdose deaths rising significantly in recent years. Despite the identification of various factors associated with overdose events, including social, demographic, psychiatric, and neonatal outcomes, the relative contributions of these factors to peripartum overdose history (or lack thereof) remain unclear. Thus, this study aims to characterize factors associated with lifetime opioid-involved overdose events among currently pregnant individuals receiving buprenorphine (BUP) treatment for OUD.   Methods: Treatment-seeking pregnant individuals with an estimated gestational age of 6 to 30 weeks were enrolled in a large multisite randomized …

Charge‐Governed Mechanistic Evaluation Of Aav2 Clarification Via Functionalized Flat Sheet And Hollow Fiber Deconstructed Depth Filters, Mara Baughman‐Leach, Mattie Brock, Malgorzata Chwatko, Dibakar Bhattacharyya

Chemical and Materials Engineering Faculty Publications

The expansion of adeno-associated virus (AAV)-based therapeutics has increased the demand for efficient clarification. In this study, a functionalized deconstructed depth filtration platform was developed to dissect how membrane–virus charge, modulated by pH, influences separation. Three charge regimes, positive (pH 4), neutral (pH 6), and negative (pH 8) between the membranes and AAVs, were examined. The flat-sheet system, composed of sequential 1.2, 0.8, 0.45, and 0.1 µm membranes, enabled the first layer-by-layer analysis of depth filtration behavior. This revealed that Stage 1 and Stage 4 dominate clarification. Remarkably, substantial DNA capture (> 75%) was observed even in the largest-pore stage, …

Brain-Derived Extracellular Vesicles Potentially Mediate Crosstalk With Peripheral Organs In Neurodegenerative Diseases, Ramzi H. Hamdalla, Vibha B. Bhaskar, Changhai Tian

Toxicology and Cancer Biology Faculty Publications

Brain-Derived Extracellular vesicles (BDEVs) are emerging mediators of intra- and interorgan communication in neurodegenerative diseases (NDs) such as Alzheimer’s Disease (AD) and Parkinson’s Disease (PD). A growing body of evidence suggests that BDEVs play an important role in modulating intercellular communication within the central nervous system in the pathogenesis of many NDs. By transporting non-coding RNAs (e.g., miRNAs) and important pathological proteins, BDEVs also influence peripheral organs and contribute to the progression of disease in the central nervous system (CNS). This review extends the understanding of NDs beyond solely brain dysfunction and gives a novel framework for the progression of …

Current Concepts In Hip And Core Assessment To Reduce The Risk Of Acl Injury, Jeremy M. Burnham, Anthony T. Drazick, Ghislain Aminake, Darren L. Johnson, Mary Lloyd Ireland, Brian W. Noehren

Orthopaedic Surgery and Sports Medicine Faculty Publications

Background: Hip and trunk (“core”) muscle dysfunction has emerged as a modifiable contributor to lower-limb biomechanics linked with non-contact anterior cruciate ligament (ACL) injuries. Clinicians increasingly target core stability and control during injury-prevention screening and post-operative rehabilitation programs; however, the literature lacks a focused synthesis of core-directed strategies for ACL injury mitigation. The purpose of this current concepts review is to synthesize current evidence on hip- and core-focused assessment and rehabilitation strategies that may mitigate ACL injury risk.

Design: Current Concepts Review.

Methods: A narrative search of PubMed and Google Scholar (January 2000 – April 2025) identified biomechanical, prospective, interventional, …