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Full-Text Articles in Entire DC Network
Establishing Performance Criteria For Evaluating Watershed-Scale Sediment And Nutrient Models At Fine Temporal Scales, Aayush Pandit, Sarah Hogan, David Tyler Mahoney, William I. Ford, James F. Fox, Christopher Wellen, Admin Husic
Establishing Performance Criteria For Evaluating Watershed-Scale Sediment And Nutrient Models At Fine Temporal Scales, Aayush Pandit, Sarah Hogan, David Tyler Mahoney, William I. Ford, James F. Fox, Christopher Wellen, Admin Husic
Civil Engineering Faculty Publications
Watershed water quality models are mathematical tools used to simulate processes related to water, sediment, and nutrients. These models provide a framework that can be used to inform decision-making and the allocation of resources for watershed management. Therefore, it is critical to answer the question “when is a model good enough?” Established performance evaluation criteria, or thresholds for what is considered a ‘good’ model, provide common benchmarks against which model performance can be compared. Since the publication of prior meta-analyses on this topic, developments in the last decade necessitate further investigation, such as the advancement in high performance computing, the …
An Approach To Quantifying The Lifecycle Sustainability Impacts Of Tungsten Carbide Tools, Gatewood Arnold, Julian Polizzi, Syed Ibn Mohsin, Daniel Carnesi, Julius Schoop, Fazleena Badurdeen
An Approach To Quantifying The Lifecycle Sustainability Impacts Of Tungsten Carbide Tools, Gatewood Arnold, Julian Polizzi, Syed Ibn Mohsin, Daniel Carnesi, Julius Schoop, Fazleena Badurdeen
Mechanical Engineering Faculty Publications
Tungsten carbide cutting tools are widely used for their high machining performance and low cost. However, their cost does not currently reflect the material rarity, environmental costs, nor societal costs associated with their production. Critically, embodied energy makes a sizeable contribution to the total lifecycle energy consumption. This study quantifies the true triple bottom line cost of the tools with respect to established sustainability metrics by leveraging cross-disciplinary insights from the product, process, and system levels. Based on the adjusted cost, a comparative analysis of the cutting tool sustainability on the profitability of a nickel-based superalloy machining process was carried …
A Multi-Scale Finite Element Method For Investigating Fiber Remodeling In Hypertrophic Cardiomyopathy, Mohammad Mehri, Kenneth S. Campbell, Lik Chuan Lee, Jonathan F. Wenk
A Multi-Scale Finite Element Method For Investigating Fiber Remodeling In Hypertrophic Cardiomyopathy, Mohammad Mehri, Kenneth S. Campbell, Lik Chuan Lee, Jonathan F. Wenk
Mechanical Engineering Faculty Publications
A significant hallmark of hypertrophic cardiomyopathy (HCM) is fiber disarray, which is associated with various cardiac events such as heart failure. Quantifying fiber disarray remains critical for understanding the disease’s complex pathophysiology. This study investigates the role of heterogeneous HCM-induced cellular abnormalities in the development of fiber disarray and their subsequent impact on cardiac pumping function. Fiber disarray is predicted using a stress-based law to reorient myofibers and collagen within a multiscale finite element cardiac modeling framework, MyoFE. Specifically, the model is used to quantify the distinct impacts of heterogeneous distributions of hypercontractility, hypocontractility, and fibrosis on fiber disarray development …
Effect Of Walking With An Active Ankle Exoskeleton On The Biomechanical Responses Of The Lumbar Spine, Jose E. Rubio, Junfei Tong, Aravind Sundaramurthy, Anup Pant, Sridevi Nagaraja, Meredith K. Owen, Michael A. Samaan, Brian W. Noehren, Jaques Reifman
Effect Of Walking With An Active Ankle Exoskeleton On The Biomechanical Responses Of The Lumbar Spine, Jose E. Rubio, Junfei Tong, Aravind Sundaramurthy, Anup Pant, Sridevi Nagaraja, Meredith K. Owen, Michael A. Samaan, Brian W. Noehren, Jaques Reifman
Physical Therapy Faculty Publications
Objective: Musculoskeletal injuries pose a health threat to U.S. Service members. In particular, the physical demands of walking and running with load carriage contribute to a high incidence of musculoskeletal injuries of the lower back. Active ankle exoskeleton devices are promising technologies that may help mitigate the impact of load carriage on the incidence of these injuries. However, the safe extended use of these devices requires an understanding of their beneficial or detrimental effects on the lumbar spine. In this pilot study, we investigated the impact of walking with an ankle exoskeleton device on lumbar biomechanical responses.
Methods: We collected …
The Role Of Cooperative Extension In Community Development: A Study Of Success Stories And Leadership Practices, George Grant
The Role Of Cooperative Extension In Community Development: A Study Of Success Stories And Leadership Practices, George Grant
Theses and Dissertations--Educational Leadership Studies
The Cooperative Extension System (CES) plays a vital role in community education and development across the United States. CES agents and specialists work directly with community members to identify needs, mobilize existing assets, and empower action. Despite the overlap in the fields of CES and community development, few studies have systematically analyzed the specific practices used by extension personnel who act as facilitators of change within communities. To address this gap in knowledge, a qualitative study was conducted using directed content analysis of CES success stories published through the University of Kentucky to identify practices used among two integral positions …
Path-Goal Leadership Dynamics In Advanced Manufacturing Dual Credit Career And Technical Education (Cte) Classrooms In Connecticut, Kyle R. Pepin
Path-Goal Leadership Dynamics In Advanced Manufacturing Dual Credit Career And Technical Education (Cte) Classrooms In Connecticut, Kyle R. Pepin
Theses and Dissertations--Educational Leadership Studies
This dissertation examined the adaptive instructional leadership practices of instructors teaching dual credit career and technical education (CTE) classes in Connecticut, particularly in advanced manufacturing technologies (AMT). The study drew on survey responses from a broader group of course instructors and a purposeful sample of six instructors and six adult students who participated in semi-structured interviews. All instructors taught dual credit classes in partnership with Connecticut State Community College in hands-on manufacturing, engineering, or similar workshop environments designed to prepare high school aged students for careers and develop practical, job-ready skills in settings that closely replicate industry conditions. This under-researched …
From Engagement To Clarity: Understanding Career Exploration Activities And Their Influence On Career Clarity Among High School Students, Odunayo O. Omotilewa
From Engagement To Clarity: Understanding Career Exploration Activities And Their Influence On Career Clarity Among High School Students, Odunayo O. Omotilewa
Theses and Dissertations--Education Sciences
This study examined the associations between career exploration activities and career clarity among high school students in the U.S.A. Using data from the 2022 Program for International Student Assessment, collected from a national sample of 15 to 16-year-olds across 154 schools, the researcher first identified student and school factors associated with engaging in career exploration. The study then examined the influence of these activities on career clarity. Specifically, the analysis focused on internships, job shadowing, job fairs, career counseling, completing career questionnaires, researching careers and colleges online, attending college tours, and financing information, and on the level of engagement in …
Implementation Of Project-Based Instruction In Statistics Higher Education Courses, Jennifer A. Daddysman
Implementation Of Project-Based Instruction In Statistics Higher Education Courses, Jennifer A. Daddysman
Theses and Dissertations--Education Sciences
Project-based instruction is an instructional methodology based in constructivism that aligns with recommendations from the American Statistical Association for teaching statistics, including incorporating real-world data and examples, collaboration, and scaffolding (GAISE College Report ASA Revision Committee, 2016; GAISE Steering Committee, 2024; Krajcik & Blumenfeld, 2005; Tishkovskaya & Lancaster, 2012). This study examined current use of project-based instruction in United States higher education courses in statistics and the supports for and challenges to implementing this type of instruction.
This study used qualitative research methodology in the integrative pedagogy and diffusion of innovation frameworks. Voluntary response surveys were distributed via two sections …
Growing An Inquiry Practice: A Case Study Of Teacher Change In Social Studies Classrooms, Alicia Michelle Saccomanno
Growing An Inquiry Practice: A Case Study Of Teacher Change In Social Studies Classrooms, Alicia Michelle Saccomanno
Theses and Dissertations--Education Sciences
This exploratory case study examines how a group of social studies teachers refined their inquiry-based instructional practices over a school year. Research questions included: 1. How do teachers grow their use of questions, tasks, and sources? 2. What obstacles do teachers face when implementing inquiry? How do they work to overcome those obstacles? 3. How do teachers learn to trust the inquiry process, trust themselves to implement it, and trust their students to collaborate, deliberate, and produce meaningful work? This study examined teachers' design and instructional choices as well as their responses to student outcomes …
Examining How Well High School Geometry Students Learn Concepts Of Three-Dimensional Figures Using A Project-Based Instructional Strategy, Lenora A. Mcgrath
Examining How Well High School Geometry Students Learn Concepts Of Three-Dimensional Figures Using A Project-Based Instructional Strategy, Lenora A. Mcgrath
Theses and Dissertations--Education Sciences
This paper examines how well the introduction of an integrated approach, namely, Project-based Instruction (PBI), which uses real-world contexts to investigate problems, leads to improved academic performance and student motivation in a 9th Grade Geometry class studying three-dimensional figures and their properties. The experimental group worked through the researcher-designed unit that included mini-lessons, six benchmark lessons, and the design and creation of a final product to address the driving question of the unit. The comparison group experienced a normative teaching strategy designed by the classroom teacher. An explanatory sequential mixed methods design was chosen for the proposed study to …
Recipient Experiences Of Donor-Funded College Scholarships: “I Don't Know What You Want To Know About Me. I Don't Know What I Know About You.”, Teresa Waddle Gotthardt
Recipient Experiences Of Donor-Funded College Scholarships: “I Don't Know What You Want To Know About Me. I Don't Know What I Know About You.”, Teresa Waddle Gotthardt
Theses and Dissertations--Educational Policy Studies and Evaluation
This qualitative study explores the experience of receiving donor-funded scholarship support facilitated through a higher education institution, especially when the recipient has interacted with the donor of the funding. This recipient-and-donor-interaction is common at American post-secondary institutions in the form of written thank you notes and attendance at donor recognition events. This research addressed the following questions: How do donor-funded scholarship recipients experience this funding? How do donor-funded scholarship recipients experience interaction with the donor of the scholarship? These questions were explored through in-depth semi-structured interviews with 23 recent alumni from five private universities and colleges who received donor-funded scholarships …
Investigating The Psychometric Properties Of A Set Of Local Stem Literacy Instruments In Rasch Model, Lijun Shen
Investigating The Psychometric Properties Of A Set Of Local Stem Literacy Instruments In Rasch Model, Lijun Shen
Theses and Dissertations--Educational Policy Studies and Evaluation
This study investigates the psychometric features of the See Blue STEM literacy inventories (SBSTEMs, including the elementary version SB-E and the middle school version SB-M) to determine their validity in measuring STEM literacy. Using data from elementary and middle school students participating in the See Blue STEM camp in 2019 and 2021-22, this research employed the Rasch Partial Credit Model (PCM) to analyze item-level performance and identify DIF items across various demographic subgroups (race, gender, free-lunch status, and potential first-generation status) and camp delivery modes (online versus in-person). Results indicated that both the elementary (SB-E) and middle school (SB-M) versions …
From Ads To Enrollment: Understanding How Targeted Marketing Affects College Choice, John W. Roberts
From Ads To Enrollment: Understanding How Targeted Marketing Affects College Choice, John W. Roberts
Theses and Dissertations--Educational Policy Studies and Evaluation
The purpose of this qualitative study is to explore the perceived impact of targeted marketing on college choice. Research on college choice is an established area of scholarship that explores the variables that are at work when a student chooses to attend a college or university. Given that the enrollment landscape for higher education continues to be competitive, colleges and universities are doing what they can to “stand out” among the competition in a crowded marketing and advertising space. And, as technology improves, segmenting and personalizing marketing to reach the right students at the right time is becoming more commonplace …
Understanding High School Students’ Identities In Stem Through Video Elicitation, Andrea N. Perrin
Understanding High School Students’ Identities In Stem Through Video Elicitation, Andrea N. Perrin
Theses and Dissertations--Science, Technology, Engineering, and Mathematics (STEM) Education
Understanding how high school students develop their STEM identities is essential for creating inclusive and engaging learning environments that foster persistence in STEM fields. This qualitative study explores the experiences of high school seniors in an engineering capstone course within a diverse Midwestern high school, utilizing video elicitation as the primary research method. Through video interviews, transcript reviews, and thumbnail selections, students provided firsthand insights into their evolving STEM identities, sense of belonging, and the factors influencing their persistence in engineering.
Findings reveal that social interactions, autonomy in learning, hands-on experiences, and real-world applications of engineering concepts shape students' STEM …
Examining The Professional Noticing Skills, Attitudes Toward Mathematics, And Elementary Math Content Knowledge Of Preservice Elementary School Teachers Through The Noticing Numeracy Now Intervention, Johnathan T. Rogers
Theses and Dissertations--Science, Technology, Engineering, and Mathematics (STEM) Education
Abstract: This quasi-experimental study examined the impact of the Noticing Numeracy Now intervention, an intervention focused on professional noticing of children’s conceptual development in whole number and arithmetic reasoning, on preservice elementary teachers’ professional noticing skills, attitudes toward mathematics, and elementary math content knowledge. This study was based off of a previous study and intervention created by Molly Fisher, Jonathan Thomas, Edna Schack, Cindy Jong and Janet Tassell. This study used a video-based professional noticing module, consisting of four lessons, situated in the pedagogies of practice framework. Within this study, 10 students (all preservice elementary teachers) at Kentucky State University …
Investigation Of Subsurface Thermal Radiation Phenomena In Fibrous Thermal Protection Systems, Colby L. Gore
Investigation Of Subsurface Thermal Radiation Phenomena In Fibrous Thermal Protection Systems, Colby L. Gore
Theses and Dissertations--Science, Technology, Engineering, and Mathematics (STEM) Education
Atmospheric re-entry induces intense thermal stress upon vehicles through a high-enthalpy boundary layer that encompasses the craft. To protect these vehicles, numerous insulative methods, known as thermal protection systems (TPS), are deployed to protect the craft during re-entry. The TPS materials insulate the craft from intense thermal transmission that would terminate a mission. In hypersonic environments, vast temperature gradients exist, enforcing the exponential effect of thermal radiation. However, TPS materials are commonly low-density fibrous materials that allow for the potential to be penetrated by thermal radiation. A series of arc-jet tests was completed to replicate enhanced radiative conditions in a …
Black Women, Bold Science: Navigating Race, Gender, And Identity In Science, Mia L. Brown
Black Women, Bold Science: Navigating Race, Gender, And Identity In Science, Mia L. Brown
Theses and Dissertations--Science, Technology, Engineering, and Mathematics (STEM) Education
This research study examines the challenges Black women encounter when in predominantly white, male academic and professional science settings, where they experience dual discrimination because of their race and gender. These biases perpetuate the negative stereotype that Black women are less competent than white men. This mixed methods study examines how Black women navigate their race, gender, and science identities within predominantly white institutions through their doctoral programs and professional science careers. The study implements Critical Race Mixed Methodology to combine survey data for a wide reach with interview data for detailed exploration. The study involved eight Black women science …
Designing An Undergraduate Opera Workshop Curriculum For Universities, Christopher L. Burchett
Designing An Undergraduate Opera Workshop Curriculum For Universities, Christopher L. Burchett
Theses and Dissertations--Music
The world of opera is quickly evolving to keep pace with the other arts forms of film, television and Broadway theater. For many years the genre had been reluctant to change with the times and update the skills of their performers. Those days have passed. Today’s operatic performers must be better actors, better movers and more theatrically efficient with their overall skill set in addition to having the secured singing technique that has for so long been the top priority. Universities must take ownership of this training.
Today’s university opera workshop programs must be more than they have been in …
A Twenty-First Century Approach To Darius Milhaud's Saudades Do Brasil, Paige H. Crain
A Twenty-First Century Approach To Darius Milhaud's Saudades Do Brasil, Paige H. Crain
Theses and Dissertations--Music
French composer Darius Milhaud (1892-1974) lived in Rio de Janeiro, Brazil from February 1917 to November 1918. Milhaud’s experience in Rio was overwhelmingly positive, and several of his works were influenced by this period of his life, one being a suite for solo piano titled Saudades do Brasil, Op. 67. Inspired by Brazilian popular music, this piece is an example of exoticism, a trend of writing music based on cultures other than the composer’s own. Considering that exoticism historically has the potential to perpetuate harmful stereotypes or generate false information, this research delves into Saudades do Brasil, exploring …
Mental Health And Treatment Use In Undergraduate Engineering Students, Matthew D. Whitwer, Sarah A. Wilson, Joseph H. Hammer, Brenna Gomer
Mental Health And Treatment Use In Undergraduate Engineering Students, Matthew D. Whitwer, Sarah A. Wilson, Joseph H. Hammer, Brenna Gomer
Educational, School, and Counseling Psychology Faculty Publications
Background: Engineering students experience high levels of distress and low rates of mental health treatment seeking, yet there is a gap in knowledge around how this compares with that of students in other fields of study. Given the influence of social identity (e.g., gender identity, race/ethnicity) on mental health and treatment seeking, it is important to account for sociodemographic variation across fields when performing such comparisons. Purpose: This study used Andersen's Behavioral Model to compare mental health distress and treatment use between students in engineering and other fields while controlling for sociodemographic factors. Methods: Survey data came from the 2021–2022 …
Engaging Nurses In Effective Cost Of Care Conversations To Address Cancer-Related Financial Toxicity: Results From An Exploratory Survey, Jean Edward, Amanda T. Wiggins, Louis G. Baser, Haafsah Fariduddin, Joanna F. Doran, Monica F. Bryant, John August D'Orazio, Kimberly D. Northrip
Engaging Nurses In Effective Cost Of Care Conversations To Address Cancer-Related Financial Toxicity: Results From An Exploratory Survey, Jean Edward, Amanda T. Wiggins, Louis G. Baser, Haafsah Fariduddin, Joanna F. Doran, Monica F. Bryant, John August D'Orazio, Kimberly D. Northrip
Markey Cancer Center Faculty Publications
Few evidence-based trainings exist on how to equip healthcare providers, particularly nurses, with the skills to engage in cost of care conversations with patients/caregivers to mitigate the impact of cancer-related financial toxicity. This study evaluated a pilot training developed in collaboration with Triage Cancer® to prepare oncology nurses to identify and assist patients/caregivers facing financial and/or legal barriers to care. Ten pediatric oncology nurses completed the training and pre/post-surveys on behaviors related to financial and legal need screening, frequency and comfort level of answering questions, knowledge, and behavior changes, along with training evaluation questions. At baseline, six nurses reported never …
Pharmacological Or Genetic Inhibition Of Ltcc Promotes Cardiomyocyte Proliferation Through Inhibition Of Calcineurin Activity, Lynn A. C. Devilée, Abou Bakr M. Salama, Jessica M. Miller, Janice D. Reid, Qinghui Ou, Nourhan M. Baraka, Kamal Abou Farraj, Madiha Jamal, Yibing Nong, Todd K. Rosengart, Douglas A. Andres, Jonathan Satin, Tamer M. A. Mohamed, James E. Hudson, Riham R. E. Abouleisa
Pharmacological Or Genetic Inhibition Of Ltcc Promotes Cardiomyocyte Proliferation Through Inhibition Of Calcineurin Activity, Lynn A. C. Devilée, Abou Bakr M. Salama, Jessica M. Miller, Janice D. Reid, Qinghui Ou, Nourhan M. Baraka, Kamal Abou Farraj, Madiha Jamal, Yibing Nong, Todd K. Rosengart, Douglas A. Andres, Jonathan Satin, Tamer M. A. Mohamed, James E. Hudson, Riham R. E. Abouleisa
Markey Cancer Center Faculty Publications
Cardiomyocytes (CMs) lost during ischemic cardiac injury cannot be replaced due to their limited proliferative capacity. Calcium is an important signal transducer that regulates key cellular processes, but its role in regulating CM proliferation is incompletely understood. Here we show a robust pathway for new calcium signaling-based cardiac regenerative strategies. A drug screen targeting proteins involved in CM calcium cycling in human embryonic stem cell-derived cardiac organoids (hCOs) revealed that only the inhibition of L-Type Calcium Channel (LTCC) induced the CM cell cycle. Furthermore, overexpression of Ras-related associated with Diabetes (RRAD), an endogenous inhibitor of LTCC, induced CM cell cycle …
Advances In Magnetic Nanoparticles For Molecular Medicine, Xiaoyue Yang, Sarah E. Kubican, Zhongchao Yi, Sheng Tong
Advances In Magnetic Nanoparticles For Molecular Medicine, Xiaoyue Yang, Sarah E. Kubican, Zhongchao Yi, Sheng Tong
Markey Cancer Center Faculty Publications
Magnetic nanoparticles (MNPs) are highly versatile nanomaterials in nanomedicine, owing to their diverse magnetic properties, which can be tailored through variations in size, shape, composition, and exposure to inductive magnetic fields. Over four decades of research have led to the clinical approval or ongoing trials of several MNP formulations, fueling continued innovation. Beyond traditional applications in drug delivery, imaging, and cancer hyperthermia, MNPs have increasingly advanced into molecular medicine. Under external magnetic fields, MNPs can generate mechano- or thermal stimuli to modulate individual molecules or cells deep within tissue, offering precise, remote control of biological processes at cellular and molecular …
Engaging Nurses In Effective Cost Of Care Conversations To Address Cancer-Related Financial Toxicity: Results From An Exploratory Survey, Jean Edward, Abigail Wiggins, Louis G. Baser, Haafsah Fariduddin, Joanna F. Doran, Monica F. Bryant, John A. D'Orazio, Kimberly D. Northrip
Engaging Nurses In Effective Cost Of Care Conversations To Address Cancer-Related Financial Toxicity: Results From An Exploratory Survey, Jean Edward, Abigail Wiggins, Louis G. Baser, Haafsah Fariduddin, Joanna F. Doran, Monica F. Bryant, John A. D'Orazio, Kimberly D. Northrip
Markey Cancer Center Faculty Publications
Few evidence-based trainings exist on how to equip healthcare providers, particularly nurses, with the skills to engage in cost of care conversations with patients/caregivers to mitigate the impact of cancer-related financial toxicity. This study evaluated a pilot training developed in collaboration with Triage Cancer® to prepare oncology nurses to identify and assist patients/caregivers facing financial and/or legal barriers to care. Ten pediatric oncology nurses completed the training and pre/post-surveys on behaviors related to financial and legal need screening, frequency and comfort level of answering questions, knowledge, and behavior changes, along with training evaluation questions. At baseline, six nurses reported never …
Functional Assessment Of Migration And Adhesion To Quantify Cancer Cell Aggression, Lauren E. Mehanna, James D. Boyd, Chloe G. Walker, Adrianna R. Osborne, Martha E. Grady, Brad J. Berron
Functional Assessment Of Migration And Adhesion To Quantify Cancer Cell Aggression, Lauren E. Mehanna, James D. Boyd, Chloe G. Walker, Adrianna R. Osborne, Martha E. Grady, Brad J. Berron
Markey Cancer Center Faculty Publications
During epithelial-to-mesenchymal transition (EMT), cancer cells lose their cell–cell adhesion junctions as they become more metastatic, altering cell motility and focal adhesion disassembly associated with increased detachment from the primary tumor and a migratory response into nearby tissue and vasculature. Current in vitro strategies characterizing a cell’s metastatic potential heavily favor quantifying the presence of cell adhesion biomarkers through biochemical analysis; however, mechanical cues such as adhesion and motility directly relate to cell metastatic potential without needing to first identify a cell specific biomarker for a particular type of cancer. This paper presents a comprehensive comparison of two functional metrics …
M1 Macrophage‑Engineered Vesicles Have Anti‑Cancer Activity In Ovarian Cancer, Connie D. Cao, J. Robert Mccorkle, Derek B. Allison, Donglin Yan, Kristen S. Hill, Lan Li, Rani Jayswal, David Schweer, Charles S. Dietrich Iii, Frederick R. Ueland, Christopher I. Richards, Jill M. Kolesar
M1 Macrophage‑Engineered Vesicles Have Anti‑Cancer Activity In Ovarian Cancer, Connie D. Cao, J. Robert Mccorkle, Derek B. Allison, Donglin Yan, Kristen S. Hill, Lan Li, Rani Jayswal, David Schweer, Charles S. Dietrich Iii, Frederick R. Ueland, Christopher I. Richards, Jill M. Kolesar
Markey Cancer Center Faculty Publications
Background: Ovarian cancer typically presents at an advanced stage, has a poor prognosis, and is a leading cause of cancer-related deaths in women. Extracellular vesicles (EVs) are cell membrane-derived nanoparticles that function in specific cell- to-cell communication and are under development as novel drug delivery vehicles and modulators of the tumor microenvironment. Artificial cell-derived vesicles (ACDVs) from M1 macrophages are able to repolarize macrophages from a M2 to a M1 phenotype and target tumor cells in in vitro studies.
Results: In this study, we generated engineered EVs (EEVs) by membrane disruption of M1 macrophages (MEVs) with and without cisplatin to …
Cisplatin-Loaded M1 Macrophage-Derived Vesicles Have Anti-Cancer Activity In Osteosarcoma, Namrata Anand, Joseph Robert Mccorkle, David Schweer, Lan Li, Kristen S. Hill, Melissa A. Fath, Derek B. Allison, Christopher L. Richards, Jill M. Kolesar
Cisplatin-Loaded M1 Macrophage-Derived Vesicles Have Anti-Cancer Activity In Osteosarcoma, Namrata Anand, Joseph Robert Mccorkle, David Schweer, Lan Li, Kristen S. Hill, Melissa A. Fath, Derek B. Allison, Christopher L. Richards, Jill M. Kolesar
Markey Cancer Center Faculty Publications
Osteosarcoma (OS) is a relatively rare bone malignancy that primarily affects children and young adults and is associated with significant morbidity and mortality. Cisplatin is a mainstay of treatment, but its efficacy is limited by off-target toxicities. Immunotherapy is not effective due to a poor antigenic tumor microenvironment. Here, we address these challenges by using manufactured M1 macrophage-derived vesicles (MVs) loaded with cisplatin. Human blood and mouse RAW 264.7 M1 macrophages were used to prepare empty (E-MVs) and cisplatin-loaded MVs (C-MVs). Human OS cell lines were used in vitro and in a tibia xenograft mouse model to evaluate the anti-cancer …
Fault Identification And Localization In Distribution Grids Based On An Attention-Hybrid Graph Neural Network, Xingjian Shan
Fault Identification And Localization In Distribution Grids Based On An Attention-Hybrid Graph Neural Network, Xingjian Shan
Theses and Dissertations--Electrical and Computer Engineering
This thesis proposes a multi-task fault diagnosis framework for distribution systems based on Graph Convolutional Networks (GCN) and an enhanced Graph Attention Network (GATv2). By representing the power grid as a graph with electrical features and topological connections, the model simultaneously performs fault type classification and fault location prediction. The architecture incorporates residual connections, multi-head attention, and a Jumping Knowledge module to capture multi-scale structural patterns, while dynamic loss weighting ensures balanced task optimization under noise and sparsity. Experimental results on the IEEE 123-node test feeder demonstrate a fault classification accuracy of 96.43%, and fault localization accuracies of 84.64% (strict), …
Surface Morphology And Moisture Adsorption/Desorption Characteristics Of Hybrid-Dielectric Moisture Sensors, Ronak Ali
Theses and Dissertations--Electrical and Computer Engineering
Relative humidity sensors are used for high-humidity measurement. Moisture sensors, or dew point sensors are used for low-humidity measurement (< 1 ppmv). The dissertation contains two parts of studies. In the first part, the effect of surface morphology on the response speed of moisture sensors is studied. Moisture sensors using α-Al2O3 films as porous dielectric materials deposited by anodic spark deposition are studied. In this part of the study, a variety of small pores have been studied to investigate the response speed of moisture sensors. Three different surface morphologies have been studied using scanning electron microscopy. One …
Measurement Of Moisture Levels In Oils And Lubricants Using A Novel Moisture Sensor, Aaron Swartz
Measurement Of Moisture Levels In Oils And Lubricants Using A Novel Moisture Sensor, Aaron Swartz
Theses and Dissertations--Electrical and Computer Engineering
It is very challenging to measure moisture levels in oils. There is not a good method to measure it. Using the novel moisture sensor, we tried various methods to measure the moisture levels in oils. The initial trials are to immerse the sensor chip into the oils to see any sensor reading changes with the change of moisture levels in oils. It was observed that the sensor reading was unstable. The idea for immersion of the sensor chip into the oils failed. The last idea is to heat the oil to let all moisture evaporate fully. Before heating, the dew …