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Maternal Occupational Exposure To Noise, Kristen W. Van Buren, Carissa M. Rocheleau, I. Chen Chen, Wayne T. Sanderson, Leslie A. Macdonald, Elizabeth A. Masterson, Eirini Nestoridi, Elizabeth C. Ailes May 2025

Maternal Occupational Exposure To Noise, Kristen W. Van Buren, Carissa M. Rocheleau, I. Chen Chen, Wayne T. Sanderson, Leslie A. Macdonald, Elizabeth A. Masterson, Eirini Nestoridi, Elizabeth C. Ailes

Epidemiology and Environmental Health Faculty Publications

Objectives We investigated associations between occupational noise and gestational diabetes mellitus, pregnancy-related hypertension (including pre-eclampsia/eclampsia), preterm birth and small for gestational age (SGA) infants. Methods Data were analysed for 7889 singleton, live-born infants without major birth defects or chromosomal disorders and their mothers from the National Birth Defects Prevention Study from 1997 to 2011. Typical maternal occupational noise exposure in all jobs held from 1 month prior to conception through the end of pregnancy was estimated by expert rater and categorised as quiet (<60 A-weighted decibels (dBA)), low (60-75 dBA), moderate (76-84 dBA) or loud (>85 dBA). Multiple logistic regression was used to estimate associations (adjusted ORs and 95% CIs) between …

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On The Optimal Design Of Coreless Afpm Machines With Halbach Array Rotors For Electric Aircraft Propulsion, Matin Vatani, John F. Eastham, Xiaoze Pei, Dan M. Ionel May 2025

On The Optimal Design Of Coreless Afpm Machines With Halbach Array Rotors For Electric Aircraft Propulsion, Matin Vatani, John F. Eastham, Xiaoze Pei, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

This paper provides a comprehensive analysis of the winding factor and winding harmonic distribution in coreless stator axial flux permanent magnet (AFPM) machines. The topology of this type of machine and its similarities to conventional cored AFPM machines are discussed. Popular pole/coil number combinations in coreless stator AFPM machines are identified and analyzed in detail. It is demonstrated that the winding factor in these machines varies with radius and can be expressed as the product of the conductor distribution factor, pitch factor, and coil group factor. The formulas for each factor are derived and presented in multiple forms based on …

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Hybrid Fea And Meta-Modeling For De Optimization Of A Highly Saturated Spoke Ipm, Oluwaseun A. Badewa, Marcelo Silva, Rosemary E. Alden, Pedram Asef, Dan M. Ionel May 2025

Hybrid Fea And Meta-Modeling For De Optimization Of A Highly Saturated Spoke Ipm, Oluwaseun A. Badewa, Marcelo Silva, Rosemary E. Alden, Pedram Asef, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

This paper introduces a novel approach for high performance electric motor design that combines machine learning (ML)-based meta-modeling with a differential evolution (DE) optimization algorithm. The method leverages finite element analysis (FEA) results to train the ML meta-model, enabling efficient design optimization for high-power density cored machines, such as spoke interior permanent magnet motors (IPM), which exhibit complex nonlinearities and saturation effects. This hybrid ML-DE framework seeks to provide an alternative for physics-based electric motor design and optimization, offering significant reductions in computational effort while maintaining accuracy. The meta-model’s accuracy in capturing the nonlinear relationships between design parameters, core losses, …

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Optimal Design Of Coreless Axial Flux Pm Machines Using A Hybrid Machine Learning And Differential Evolution Method, Matin Vatani, David R. Stewart, Pedram Asef, Dan M. Ionel May 2025

Optimal Design Of Coreless Axial Flux Pm Machines Using A Hybrid Machine Learning And Differential Evolution Method, Matin Vatani, David R. Stewart, Pedram Asef, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

Coreless stator axial flux permanent magnet (AFPM) machines require computationally intensive three dimensional finite element analysis (FEA) for accurate performance evaluation, making optimization time-consuming and impractical for large-scale design studies. This paper presents a hybrid optimization approach that integrates differential evolution (DE) with artificial neural networks (ANNs) to accelerate the optimization of coreless AFPM machines. In this method, DE driven FEA simulations generate a dataset used to train an ANN surrogate model, significantly reducing reliance on direct FEA computations. The effectiveness of this approach is demonstrated through a multi-objective DE optimization, where the ANN’s predictions are validated against FEA results. …

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Winding Factors And Harmonics Of Coreless Axial Flux Pm Machines, Matin Vatani, John F. Eastham, Xiaoze Pei, Dan M. Ionel May 2025

Winding Factors And Harmonics Of Coreless Axial Flux Pm Machines, Matin Vatani, John F. Eastham, Xiaoze Pei, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

This paper provides a comprehensive analysis of the winding factor and winding harmonic distribution in coreless stator axial flux permanent magnet (AFPM) machines. The topology of this type of machine and its similarities to conventional cored AFPM machines are discussed. Popular pole/coil number combinations in coreless stator AFPM machines are identified and analyzed in detail. It is demonstrated that the winding factor in these machines varies with radius and can be expressed as the product of the conductor distribution factor, pitch factor, and coil group factor. The formulas for each factor are derived and presented in multiple forms based on …

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Support Effects On Fe- Or Cu-Promoted Ni Catalysts Used In The Catalytic Deoxygenation Of Tristearin To Fuel-Like Hydrocarbons, Great C. Umenweke, Robert Pace, Thomas Récalt, Olivier Heintz, Gilles Caboche, Eduardo Santillan-Jimenez May 2025

Support Effects On Fe- Or Cu-Promoted Ni Catalysts Used In The Catalytic Deoxygenation Of Tristearin To Fuel-Like Hydrocarbons, Great C. Umenweke, Robert Pace, Thomas Récalt, Olivier Heintz, Gilles Caboche, Eduardo Santillan-Jimenez

Chemistry Faculty Publications

Previous studies have shown that fats, oils, and greases (FOG) can be deoxygenated to fuel-like hydrocarbons over inexpensive alumina-supported Ni catalysts promoted with Cu or Fe to afford excellent yields of renewable diesel (RD). In this study, supports other than alumina—namely, SiO2-Al2O3, Ce0.8Pr0.2O2, and ZrO2—were investigated to develop catalysts showing improved RD yields and resistance to coke-induced deactivation relative to Al2O3-supported catalysts. Results showed that catalysts supported on Ce0.8Pr0.2O2 and ZrO2 outperformed SiO2-Al2 …

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Probing The Critical Element Chemistry Of Coal-Combustion Fly Ash, Debora Berti, John G. Groppo, Prakash Joshi, Dorin V. Preda, David P. Gamliel, Todd Beers, Michael Schrock, Shelley D. Hopps, Tonya D. Morgan, Bernd Zechmann, James C. Hower May 2025

Probing The Critical Element Chemistry Of Coal-Combustion Fly Ash, Debora Berti, John G. Groppo, Prakash Joshi, Dorin V. Preda, David P. Gamliel, Todd Beers, Michael Schrock, Shelley D. Hopps, Tonya D. Morgan, Bernd Zechmann, James C. Hower

Earth and Environmental Sciences Faculty Publications

Along with the principal rare earth (REE) minerals such as monazite, xenotime, and bastnasite, Y-and REE-bearing zircon and associated minerals survive the combustion process and are found in coal-combustion fly ash. Beneficiated fly ash from a power plant burning an eastern-Kentucky-sourced coal blend was found to have zircon (ZrSiO4), baddeleyite (ZrO2), fergusonite (YNbO4), yttriaite (Y2O3), and xenotime (YPO4). Previous studies of the same fly had also identified monazite with a broad REE suite. Scanning electron microscopy–electron dispersive spectroscopy (EDS) and transmission electron microscopy (TEM)–EDS as well as other …

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Therapeutic Applications Of A Novel Humanized Monoclonal Antibody Targeting Chemokine Receptor Ccr9 In Pancreatic Cancer, Hannah G. Mcdonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash Pandalai, Mautin Barry-Hundeyin, Megan Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca-Lema, Elia Álvarez-Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim May 2025

Therapeutic Applications Of A Novel Humanized Monoclonal Antibody Targeting Chemokine Receptor Ccr9 In Pancreatic Cancer, Hannah G. Mcdonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash Pandalai, Mautin Barry-Hundeyin, Megan Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca-Lema, Elia Álvarez-Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim

Markey Cancer Center Faculty Publications

The relative failure of immune checkpoint inhibitors in pancreatic ductal adenocarcinoma (PDAC) despite having a dense, immunosuppressive tumor microenvironment highlights the need to target alternate/escape pathways. We have previously examined C–C chemokine receptor type 9 (CCR9) as a candidate immune checkpoint and developed a targeted, humanized monoclonal antibody (SRB2). Cytotoxicity of SRB2 was evaluated in vitro and in vivo. CCR9 expression on PDAC cells/tissues, immune components of patient-derived organoids (PDOs), and antibody-dependent cell-mediated cytotoxicity were examined. In PANC-1 and MIA PaCa-2 cell lines, we demonstrated highest CCR9 expression; however, no direct cytotoxic effect was observed with SRB2 treatment. In PANC-1 …

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An Agrin-Yap/Taz Rigidity Sensing Module Drives Egfr-Addicted Lung Tumorigenesis., Reza Bayat Mokhtari, Divyaleka Sampath, Paige Eversole, Melissa Ong Yu Lin, Dmitriy A. Bosykh, Gandhi T. K. Boopathy, Aravind Sivakumar, Cheng-Chun Wang, Ramesh Kumar, Joe Yeong Poh Sheng, Ellen Karasik, Barbara A. Foster, Han Yu, Xiang Ling, Wenjie Wu, Fengzhi Li, Zoë Weaver Ohler, Christine Fillmore Brainson, David W. Goodrich, Wanjin Hong, Sayan Chakraborty May 2025

An Agrin-Yap/Taz Rigidity Sensing Module Drives Egfr-Addicted Lung Tumorigenesis., Reza Bayat Mokhtari, Divyaleka Sampath, Paige Eversole, Melissa Ong Yu Lin, Dmitriy A. Bosykh, Gandhi T. K. Boopathy, Aravind Sivakumar, Cheng-Chun Wang, Ramesh Kumar, Joe Yeong Poh Sheng, Ellen Karasik, Barbara A. Foster, Han Yu, Xiang Ling, Wenjie Wu, Fengzhi Li, Zoë Weaver Ohler, Christine Fillmore Brainson, David W. Goodrich, Wanjin Hong, Sayan Chakraborty

Markey Cancer Center Faculty Publications

Despite epidermal growth factor receptor (EGFR) is a pivotal oncogene for several cancers, including lung adenocarcinoma (LUAD), how it senses extracellular matrix (ECM) rigidity remain elusive in the context of the increasing role of tissue rigidity on various hallmarks of cancer development. Here it is shown that EGFR dictates tumorigenic agrin expression in lung cancer cell lines, genetically engineered EGFR-driven mouse models, and human specimens. Agrin expression confers substrate stiffness-dependent oncogenic attributes to EGFR-reliant cancer cells. Mechanistically, agrin mechanoactivates EGFR through epidermal growth factor (EGF)-dependent and independent modes, thereby sensitizing its activity toward localized cancer cell-ECM adherence and bulk rigidity …

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Somatic Embryogenesis From Mature Embryo Of Tall Wheatgrass (Agropyron Elongatum) And Effects Of Nacl On Induction And Growth Of Callus From Its Different Explants, Shi Decheng, Xi Ti, Zhu Tingcheng Apr 2025

Somatic Embryogenesis From Mature Embryo Of Tall Wheatgrass (Agropyron Elongatum) And Effects Of Nacl On Induction And Growth Of Callus From Its Different Explants, Shi Decheng, Xi Ti, Zhu Tingcheng

IGC Proceedings (1977-2023)

Since it has been found that the plant regeneration of gra­mineous plants can be realized through somatic embryo genesis, a great development of tissue culture is obtained not only in cereals but also in grasses, which makes possible the genetic engineering and production of artificial seed. In addition, a progress has been made in selection of various valuable mutants by inducing calli or cells cultured to vary. For exam­ple, Zhou (1986) by inducing tobacco tissue on a medium con­taining 0.5 % NaCl has got NaCl-tolerant callus; then the callus were selected by increasing progressively the concen­tration of NaCl and finally …

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Agrobacterium Mediated Transformation In Forage Legumes, F Damiani, F Pupilli, S Arcioni, M Pezzotti Apr 2025

Agrobacterium Mediated Transformation In Forage Legumes, F Damiani, F Pupilli, S Arcioni, M Pezzotti

IGC Proceedings (1977-2023)

Plant transformation is a promising tool for plant breeding. It allows the introgression in the plant genome of alien genes. At the moment few, if any, genes of agronomical value have been cloned and are available for genetic engineering works ; on the contrary, some genes encoding for antibiotic resistance are available. The use of these genes allows an easy detection of transformation events and confers useful characters for in vitro selection. A direct application of antibiotic resistance is in the selection of hybrid colonies after protoplast fusion ofparentals resistant to different antibiotics. Transformation using Agrobacterium tumef aciens or Agrobacterium …

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Genetic Engineering For Pastures, W J. Peacock Apr 2025

Genetic Engineering For Pastures, W J. Peacock

IGC Proceedings (1977-2023)

The flrst genetically engineered food products frolll hotticultural production systems are now enlering the Market and field trials of genetically engineered crop species are well advanced. We can expect that a range of crop cultivars, in which genetic engineering is n component of the breeding process, will soon go into broad ncre agriculture. Pasture species are nut far behind. Gene transfer systems are in place for a number of temperate and tropical pasture legumes and even for a few species of more dlrficult grasses. Genetic transfer systems are In place for a numoec of temperate and tropical pastvce legumes and …

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Smart Home Hvac Digital Twin Ml Meta-Model For Electric Power Distribution Systems With Solar Pv And Cta-2045 Controls, Rosemary E. Alden, Evan S. Jones, Steven B. Poore, Dan M. Ionel Apr 2025

Smart Home Hvac Digital Twin Ml Meta-Model For Electric Power Distribution Systems With Solar Pv And Cta-2045 Controls, Rosemary E. Alden, Evan S. Jones, Steven B. Poore, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

Building modeling, specifically heating, ventilation, and air conditioning (HVAC) load and equivalent energy storage calculations, represent a key focus for decarbonization of buildings and smart grid controls. In this paper, an ultra-fast one minute resolution Hybrid Machine Learning Model (HMLM) is proposed as part of a novel contribution in the field of residential physics-based smart home surrogate modeling. Emulation of white box models, or digital twins, with editable parameters through machine learning (ML) meta-modeling serves as an alternative to wide-spread experimental big data collection. The HMLM employs combined k-means clustering with multiple linear regression (MLR) to emulate minutely HVAC power …

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Mo-Substitution In V2O5 Tunes The Structure Towards Three-Dimensional Connectivity And Improves Li-Ion Battery Cycling, Kausturi Parui, Bonnie G. Gardner, Kathryn A. Pitton, Noah G. Caracuel, Emily Vidal-Torres, Shornam Gandhi, Beth S. Guiton, Juan C. Nino, Megan M. Butala Apr 2025

Mo-Substitution In V2O5 Tunes The Structure Towards Three-Dimensional Connectivity And Improves Li-Ion Battery Cycling, Kausturi Parui, Bonnie G. Gardner, Kathryn A. Pitton, Noah G. Caracuel, Emily Vidal-Torres, Shornam Gandhi, Beth S. Guiton, Juan C. Nino, Megan M. Butala

Chemistry Faculty Publications

The development of alternative energy sources is crucial for reducing reliance on fossil fuels, particularly for mobile applications such as personal electronics and transportation. This necessitates the advancement of battery materials based on abundant and inexpensive constituent elements. To achieve this requires investigating materials in a broader compositional and structural design space. Early transition metal oxides, including the intercalation electrode α − V2O5, however, the performance of V2O5 is hindered by phase transformations during battery cycling that lead to capacity fade and short device lifetimes. This study investigates the modification of V2 …

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Clustering Individuals Using Inmtd, Zuqi Li, Sam F.L. Windels, Noël Malod-Dognin, Seth M. Weinberg, Mary L. Marazita, Susan Walsh, Mark D. Shriver, David W. Fardo, Peter Claes, Nataša Przulj, Kristel Van Steen Apr 2025

Clustering Individuals Using Inmtd, Zuqi Li, Sam F.L. Windels, Noël Malod-Dognin, Seth M. Weinberg, Mary L. Marazita, Susan Walsh, Mark D. Shriver, David W. Fardo, Peter Claes, Nataša Przulj, Kristel Van Steen

Biostatistics Faculty Publications

Motivation: Combining omics and images can lead to a more comprehensive clustering of individuals than classic single-view approaches. Among the various approaches for multi-view clustering, nonnegative matrix tri-factorization (NMTF) and nonnegative Tucker decomposition (NTD) are advantageous in learning low-rank embeddings with promising interpretability. Besides, there is a need to handle unwanted drivers of clusterings (i.e. confounders). Results: In this work, we introduce a novel multi-view clustering method based on NMTF and NTD, named INMTD, which integrates omics and 3D imaging data to derive unconfounded subgroups of individuals. According to the adjusted Rand index, INMTD outperformed other clustering methods on a …

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Novel Approaches To Analyze Consumer Behavior And Policies To Promote Sustainable Consumption, Bhagyashree Katare, Xuejian Wang, Shuoli Zhao, Jacqueline Yenerall Apr 2025

Novel Approaches To Analyze Consumer Behavior And Policies To Promote Sustainable Consumption, Bhagyashree Katare, Xuejian Wang, Shuoli Zhao, Jacqueline Yenerall

Agricultural Economics Faculty Publications

Technological advancements, such as online grocery shopping, have significantly transformed consumer retail environments and experiences. Effectively studying consumer behavior in these new environments requires the use of novel methodological approaches, which will also aid in developing interventions to encourage sustainable consumption. This paper begins by providing an overview of the current literature on novel approaches to analyzing consumer behavior, then provides an empirical application by examining consumer decision-making pathways within an online grocery shopping platform. Specifically, the paper focuses on exploring the consumers’ digital footprints, such as page visits, product additions and removals, and interactions with information labels to identify …

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Steroid Receptors And Coregulators: Dissemination Of Sex Differences And Emerging Technologies, Sally Pauss, Evelyn A. Bates, Genesee J. Martinez, Zane T. Bates, Zachary A. Kipp, Cassandra D. Gipson, Terry D. Hinds Jr. Apr 2025

Steroid Receptors And Coregulators: Dissemination Of Sex Differences And Emerging Technologies, Sally Pauss, Evelyn A. Bates, Genesee J. Martinez, Zane T. Bates, Zachary A. Kipp, Cassandra D. Gipson, Terry D. Hinds Jr.

Markey Cancer Center Faculty Publications

Steroid receptors are ligand-induced transcription factors that have broad functions among all living animal species, ranging from control of sex differences, body weight, stress responses, and many others. Their binding to coregulator proteins is regulated by corepressors and coactivators that interchange upon stimulation with a ligand. Coregulator proteins are an imperative and understudied aspect of steroid receptor signaling. Here, we discuss steroid receptor basics from protein domain structures that allow them to interact with coregulators and other proteins, their essential functions as transcription factors, and other elemental protein–protein interactions. We deliberate about the mechanisms that coregulators control in steroid receptor …

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Lysyl Hydroxylase 2 Glucosylates Collagen Vi To Drive Lung Cancer Progression, Shike Wang, Houfu Guo, Reo Fukushima, Masahiko Terajima, Min Liu, Guan-Yu Xiao, Lenka Koudelková, Chao Wu, Xin Liu, Jiang Yu, Emma Burris, Jun Xu, Alvise Schiavinato, William K. Russell, Mitsuo Yamauchi, Xiaochao Tan Apr 2025

Lysyl Hydroxylase 2 Glucosylates Collagen Vi To Drive Lung Cancer Progression, Shike Wang, Houfu Guo, Reo Fukushima, Masahiko Terajima, Min Liu, Guan-Yu Xiao, Lenka Koudelková, Chao Wu, Xin Liu, Jiang Yu, Emma Burris, Jun Xu, Alvise Schiavinato, William K. Russell, Mitsuo Yamauchi, Xiaochao Tan

Markey Cancer Center Faculty Publications

Lysyl hydroxylase 2 (LH2) is highly expressed in multiple tumor types and accelerates disease progression by hydroxylating lysine residues on fibrillar collagen telopeptides to generate stable collagen cross links in tumor stroma. Here, we show that a galactosylhydroxylysyl glucosyltransferase (GGT) domain on LH2 modified type-VI collagen (Col6) to promote lung adenocarcinoma (LUAD) growth and metastasis. In tumors generated by LUAD cells lacking LH2 GGT domain activity, stroma was less stiff, and stable types of collagen cross links were reduced. Mass spectrometric analysis of total and glycosylated peptides in parental and GGT-inactive tumor samples identified Col6 chain α3 (Col6a3), a component …

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Structural Assembly Of The Pas Domain Drives The Catalytic Activation Of Metazoan Pask, Sajina Dhungel, Michael Xiao, Rajesh Rajaian Pushpabai, Chintan K. Kikani Mar 2025

Structural Assembly Of The Pas Domain Drives The Catalytic Activation Of Metazoan Pask, Sajina Dhungel, Michael Xiao, Rajesh Rajaian Pushpabai, Chintan K. Kikani

Biology Faculty Publications

PAS domains are ubiquitous sensory modules that transduce environmental signals into cellular responses through tandem PAS folds and PAS-associated C-terminal (PAC) motifs. While this conserved architecture underpins their regulatory roles, here we uncover a structural divergence in the metazoan PAS domain-regulated kinase (PASK). By integrating evolutionary-scale domain mapping with deep learning-based structural models, we identified two PAS domains in PASK, namely PAS-B and PAS-C, in addition to the previously known PAS-A domain. Unlike canonical PAS domains, the PAS fold and PAC motif in the PAS-C domain are spatially segregated by an unstructured linker, yet a functional PAS module is assembled …

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Soil Compaction And Novel Traffic Systems In Ryegrass Grown For Silage: Effects On Herbage Yield, Quality And Nitrogen Uptake, J T. Douglas, C E. Crawford Mar 2025

Soil Compaction And Novel Traffic Systems In Ryegrass Grown For Silage: Effects On Herbage Yield, Quality And Nitrogen Uptake, J T. Douglas, C E. Crawford

IGC Proceedings (1977-2023)

Grassland soils, on which the crop is managed for conser­vation as silage, receive large amounts of vehicle and machinery traffic : rolling and multiple slurry and fertilizers applications, plus multiple harvests, are all activities which are potentially damaging to soil and sward. A number of short-term studies in the UK (Frame, 1987 and Frost, 1988) and elsewhere (Luten and Roozeboom, 1976, and Rasmussen and M¢ller, 1981) have indicated that dry matter yield can be reduced as a consequence of stress imparted to soil by agricultural tyres. Nevertheless, there is a general lack of information on the influence of soil compaction …

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Evaluation Of The Gelation Characteristics And Printability Of Edible Filamentous Fungi Flours And Protein Extracts, Lauren Doyle, Suvro Talukdar, Youling Xiong, Akinbode Adedeji, Tyler Barzee Mar 2025

Evaluation Of The Gelation Characteristics And Printability Of Edible Filamentous Fungi Flours And Protein Extracts, Lauren Doyle, Suvro Talukdar, Youling Xiong, Akinbode Adedeji, Tyler Barzee

Animal and Food Sciences Faculty Publications

AbstractThere is a pressing need to produce novel food ingredients from sustainable sources to support a growing population. Filamentous fungi can be readily cultivated from low-cost agricultural byproducts to produce functional proteins for food biomanufacturing of structured products. However, there is a lack of scientific knowledge on the gelling characteristics of fungal proteins or their potential in additive biomanufacturing. Therefore, this study investigated the feasibility of utilizing fungal protein extracts and flours from Aspergillus awamori, Pleurotus ostreatus, Auricularia auricula-judae as sole gelling agents in 3D-printed products. Protein extracts were successfully prepared using the alkaline extraction–isoelectric precipitation method and successful physical …

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Production Of Alinite-Chlormayenite Clinker And Its Hydration Behavior With Increasing Gypsum Content, Marco Simoni, Aniruddha Baral, Zhili Ren, Tristana Y. Duvallet, Robert B. Jewell, Christiane Rößler, Theodore Hanein Mar 2025

Production Of Alinite-Chlormayenite Clinker And Its Hydration Behavior With Increasing Gypsum Content, Marco Simoni, Aniruddha Baral, Zhili Ren, Tristana Y. Duvallet, Robert B. Jewell, Christiane Rößler, Theodore Hanein

Earth and Environmental Sciences Faculty Publications

An alternative low-energy alinite-chlormayenite clinker was produced and its hydration with different gypsum content was studied. The clinker was produced at 1225 ◦C using reagent-grade materials in an electric kiln with alinite, larnite, and chlormayenite content of 48, 24, and 16 wt%, respectively. The hydration kinetics of the clinker with different gypsum additions (0,10, 20, and 40 wt%) did not have a distinct induction period, and the hydration was faster than Portland cement. Alinite was in general more reactive than chlormayenite. In the presence of a limited amount of gypsum (10 and 20 wt%), alinite consumed gypsum to form ettringite …

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Abuse-Deterrent Formulations And Opioid-Related Harms In North Carolina, 2010-2018, Bethany L. Diprete, Nabarun Dasgupta, G. Yeon Oh, Daniela C. Moga, Svetla Slavova, Emily Slade, Chris Delcher, Brian W. Pence, Shabbar I. Ranapurwala Mar 2025

Abuse-Deterrent Formulations And Opioid-Related Harms In North Carolina, 2010-2018, Bethany L. Diprete, Nabarun Dasgupta, G. Yeon Oh, Daniela C. Moga, Svetla Slavova, Emily Slade, Chris Delcher, Brian W. Pence, Shabbar I. Ranapurwala

Epidemiology and Environmental Health Faculty Publications

Abuse-deterrent formulations of opioid analgesics (ADFs) were introduced to reduce opioid-related harms among pain patients, but postmarketing study results have been mixed. However, these studies may be subject to bias from selection criteria, comparator choice, and potential confounding by “indication,” highlighting the need for thorough study design considerations. In a sample of privately insured patients prescribed ADF or non-ADF extended-release/long-acting (ER/LA) opioids in North Carolina, we implemented a version of the prevalent new-user design to evaluate the relationship between ADFs and opioid use disorder (OUD, n = 235) and opioid overdose (n = 18) through 6 months of follow-up using …

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Quantitative And Narrative Analysis Of Dump Truck-Related Injuries And Fatalities In The United States, Terry L. Bunn, Caitlin A. Northcutt, Rebecca Honaker, Patrick Maloney Mar 2025

Quantitative And Narrative Analysis Of Dump Truck-Related Injuries And Fatalities In The United States, Terry L. Bunn, Caitlin A. Northcutt, Rebecca Honaker, Patrick Maloney

Epidemiology and Environmental Health Faculty Publications

Dump truck safety recommendations have been implemented by companies, but a comprehensive study of risk factors associated with dump truck injuries and fatalities has not been performed. Published research specifically focusing on dump truck injuries is limited. The purpose of this descriptive study was to characterize risk factors associated with dump truck-related inspection cases reported by the OSHA in the United States. Dump truck inspections during 2016–2020 were obtained from the online OSHA IMIS database. Pearson’s chi-square test and logistic regression were performed. An intraclass correlation coefficient (ICC) using PROC MIXED and a generalized linear mixed model was calculated on …

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Development Of Measures For Highway Criticality Assessment, Xu Zhang, Mei Chen Mar 2025

Development Of Measures For Highway Criticality Assessment, Xu Zhang, Mei Chen

Kentucky Transportation Center Research Report

Existing network criticality assessments, often biased towards heavily used highways in populous areas by incorporating traffic and sociodemographic attributes, can lead to an underestimation of the vital role of rural infrastructure. Consequently, rural highways, particularly low-volume roads, often receive less consideration despite their critical role in network connectivity and local access to services and economic opportunities. To address this, we develop a criticality framework based on the egalitarian principle, which prioritizes equitable consideration of all network links regardless of traffic volume or population density, comprising two complementary measures. First, the normalized betweenness centrality quantifies a road's relative importance in efficiently …

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Macroevolutionary Inference Of Complex Modes Of Chromosomal Speciation In A Cosmopolitan Plant Lineage, Carrie M. Tribble, José Ignacio Márquez-Corro, Michael R. May, Andrew L. Hipp, Marcial Escudero, Rosana Zenil-Ferguson Mar 2025

Macroevolutionary Inference Of Complex Modes Of Chromosomal Speciation In A Cosmopolitan Plant Lineage, Carrie M. Tribble, José Ignacio Márquez-Corro, Michael R. May, Andrew L. Hipp, Marcial Escudero, Rosana Zenil-Ferguson

Biology Faculty Publications

The effects of single chromosome number change—dysploidy – mediating diversification remain poorly understood. Dysploidy modifies recombination rates, linkage, or reproductive isolation, especially for one-fifth of all eukaryote lineages with holocentric chromosomes. Dysploidy effects on diversification have not been estimated because modeling chromosome numbers linked to diversification with heterogeneity along phylogenies is quantitatively challenging. We propose a new state-dependent diversification model of chromosome evolution that links diversification rates to dysploidy rates considering heterogeneity and differentiates between anagenetic and cladogenetic changes. We apply this model to Carex (Cyperaceae), a cosmopolitan flowering plant clade with holocentric chromosomes. We recover two distinct modes of …

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Scaling Covid-19 Rates With Population Size In The United States, Austin R. Cruz, Brian J. Enquist, Joseph R. Burger Mar 2025

Scaling Covid-19 Rates With Population Size In The United States, Austin R. Cruz, Brian J. Enquist, Joseph R. Burger

Biology Faculty Publications

Using county-level data from the United States, we assessed allometric scaling relationships of coronavirus disease (COVID-19) cases, deaths and age structure within and across the first four major waves of the pandemic (wild-type, alpha, delta, omicron). Results generally indicate that the burden of cases disproportionately impacted larger-sized counties, while the burden of deaths disproportionately impacted smaller counties. This may be partially due to multiple interacting social mechanisms, including a higher proportion of older adults who live in smaller counties. Moreover, these likely social mechanisms interacting with vaccinations and virus waves created a dynamic pattern whereby the rate and magnitude of …

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Crystal Structure And Hirshfeld-Surface Analysis Of The Pesticide Etoxazole, Chaluvarangaiah Sowbhagya, Thaluru M.Mohan Kumar, Hemmige S. Yathirajan, Sean Parkin Mar 2025

Crystal Structure And Hirshfeld-Surface Analysis Of The Pesticide Etoxazole, Chaluvarangaiah Sowbhagya, Thaluru M.Mohan Kumar, Hemmige S. Yathirajan, Sean Parkin

Chemistry Faculty Publications

Etoxazole (C21H23F2NO2), systematic name 4-(4-tert-butyl-2-ethoxyphenyl)-2- (2,6-difluorophenyl)-4,5-dihydro-1,3-oxazole, is a fluorinated insecticide and acaricide that inhibits chitin biosynthesis, disrupting insect development by preventing proper exoskeleton formation. Widely used in agriculture since 1998, it is readily absorbed by plant tissues and translocates within leaves. Metabolic studies have identified several oxidative degradation products, while toxicological assessments have examined potential effects, including oxidative stress. This study presents a detailed crystallographic and Hirshfeld surface analysis of etoxazole. The molecule consists of a central dihydro-oxazole ring flanked by 2,6-difluorophenyl and 4-tert-butyl-2-ethoxyphenyl groups, each twisted relative to the oxazole core. The dihydro-oxazole ring is nearly planar, with the …

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Evaluating The Physics-Based Slope Stability Program Pisa-M At A Regional Scale, Hudson J. Koch, William C. Haneberg, Matt M. Crawford, Jason M. Dortch, Meredith Swallom Mar 2025

Evaluating The Physics-Based Slope Stability Program Pisa-M At A Regional Scale, Hudson J. Koch, William C. Haneberg, Matt M. Crawford, Jason M. Dortch, Meredith Swallom

Report of Investigations--KGS

Physics based landslide modeling can be difficult and data intensive. Generating high quality and practical map results is often not feasible outside of small, thoroughly characterized study areas. Using the physics based program Probabilistic Infinite Slope Analysis (PISA m), users can perform expedient assessments of landslide hazard over large study areas where comprehensive geotechnical data may be lacking, but other data inputs are robust. PISA m uses an infinite slope equation and spatial layers, such as a digital elevation model (DEM), a lidar derived forest cover layer, and a soil map, to calculate the probability that the factor of safety …

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Quantifying Temporal Dynamics Of E. Coli Concentration And Quantitative Microbial Risk Assessment Of Pathogen In A Karst Basin, Shishir K. Sarker, Ryan T. Dapkus, Diana M. Byrne, Alan E. Fryar, Justin M. Hutchison Mar 2025

Quantifying Temporal Dynamics Of E. Coli Concentration And Quantitative Microbial Risk Assessment Of Pathogen In A Karst Basin, Shishir K. Sarker, Ryan T. Dapkus, Diana M. Byrne, Alan E. Fryar, Justin M. Hutchison

Earth and Environmental Sciences Faculty Publications

Karst aquifers can be highly productive water sources but are vulnerable to contamination by pathogens because of integrated surface and subsurface drainage. Our study focuses on the karstic Royal Spring basin in Kentucky, encompassing urban and agricultural land uses. The city of Georgetown distributes treated water from Royal Spring to over 33,000 customers. We examined E. coli dynamics at Royal Spring from June 2021 through June 2022, assessing variability under wet versus dry weather conditions. We also used quantitative microbial risk assessment (QMRA) to estimate potential health risks from the pathogenic bacterium E. coli O157:H7. E. coli concentrations in weekly …

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