Digital Commons Network^™

Students Participating As Ambassadors For Research In Kentucky (Spark): A Health Equity Undergraduate Research Training Program, Ariel A. Arthur, Rebecca L. Delacerda Allen, Fidelis Y. Sesenu, Maxwell Groznik, Carrie B. Oser, Justin X. Moore, Jessica R. Thompson, Alexis N. James, Madeline Dunfee, Philip A. Kern, Nancy Schoenberg

Center for Health Equity Transformation Faculty Publications

The Students Participating as Ambassadors for Research in Kentucky (SPARK) program provides novel health equity research training and targeted mentorship for undergraduates, particularly those from groups underrepresented in the biomedical and behavioral research and workforce. SPARK aims to address inadequate diversity in the medical and scientific research fields by providing comprehensive research mentorship and skill-building. Unlike most existing research training programs that are brief, focus on laboratory research, or are limited to graduate students and junior faculty, SPARK delivers a 16-month intensive behavioral and population health science training, equipping students with needed tools to conceptualize, plan, execute, and analyze their …

Ezh2 Inhibition Promotes Tumor Immunogenicity In Lung Squamous Cell Carcinomas, Tanner Ducote, Xiulong Song, Kassandra J. Naughton, Fan Chen, Daniel Plaugher, Avery R. Childress, Abigail R. Gellert, Erika M. Skaggs, Xufeng Qu, Jinze Liu, Jinpeng Liu, Fei Li, Kwok-Kin Wong, Christine F. Brainson

Markey Cancer Center Faculty Publications

Two important factors that contribute to resistance to immune checkpoint inhibitors (ICI) are an immune-suppressive microenvironment and limited antigen presentation by tumor cells. In this study, we examine whether in- hibition of the methyltransferase enhancer of zeste homolog 2 (EZH2) can increase ICI response in lung squamous cell carcinomas (LSCC). Our in vitro experiments using two-dimensional human cancer cell lines as well as three-dimensional murine and patient-derived organoids treated with two inhibitors of the EZH2 plus IFNγ showed that EZH2 inhibition leads to expression of both MHC class I and II (MHCI/II) expression at both the mRNA and protein levels. …

Crowdsourced Geospatial Data Is Reshaping Urban Sciences, Xiao Huang, Siqin Wang, Tianjun Lu, Yisi Liu, Leticia Serrano-Estrada

Earth and Environmental Sciences Faculty Publications

For many years, urban sciences relied heavily on traditional, authoritative data sources. However, a paradigm shift has occurred recently with the advent of citizen-driven data contribution. This evolution in data acquisition for urban science is attributable to advancements in positioning and navigation technologies, widespread use of digital devices, the rise of Web 2.0, enhanced broadband communications, and refined data management techniques. The significance of crowdsourced geospatial data in the realm of urban sciences is now widely acknowledged. A diverse array of novel data sources has been increasingly gaining prominence. These include, but are not limited to, social media platforms, street …

Crowdsourcing Geospatial Data For Earth And Human Observations: A Review, Xiao Huang, Siqin Wang, Di Yang, Tao Hu, Meixu Chen, Mengxi Zhang, Guiming Zhang, Filip Biljecki, Tianjun Lu, Lei Zou, Connor Y. H. Wu, Yoo Min Park, Xiao Li, Yunzhe Liu, Hongchao Fan, Jessica Mitchell, Zhenlong Li, Alexander Hohl

Earth and Environmental Sciences Faculty Publications

The transformation from authoritative to user-generated data landscapes has garnered considerable attention, notably with the proliferation of crowdsourced geospatial data. Facilitated by advancements in digital technology and high-speed communication, this paradigm shift has democratized data collection, obliterating traditional barriers between data producers and users. While previous literature has compartmentalized this subject into distinct platforms and application domains, this review offers a holistic examination of crowdsourced geospatial data. Employing a narrative review approach due to the interdisciplinary nature of the topic, we investigate both human and Earth observations through crowdsourced initiatives. This review categorizes the diverse applications of these data and …

Synthesis, Characterization, And Performance Assessment Of Reusable And Biodegradable Antimicrobial Polymeric Membranes For Aerosolized Pathogen Inactivation And Filtration, Ebuka Ogbuoji

Theses and Dissertations--Chemical and Materials Engineering

Air filtration technology has proven effective in purifying air by trapping particulates which can cause adverse health effects. High Efficiency Particulate Air (HEPA) filters, capable of capturing over 99.99% of PM_0.3, are recommended for critical applications. However, conventional non-woven HEPA filters rely on electrostatic interactions to trap smaller particles, which can deplete over time or after cleaning, reducing filtration efficiency and posing health risks. Additionally, these filters contribute to plastic waste.

This dissertation investigated the feasibility of using flat sheet polymeric membranes fabricated via nonsolvent-induced phase separation (NIPS) as reusable and biodegradable alternatives to commercially available non-biodegradable air …

Evaluating The External Human-Machine Interface Of Autonomous Vehicles On Pedestrian Safety At Mid-Block Crossings: A Virtual Reality-Enabled Simulation Study, Zizheng Yan, Hong Yang, Junqing Wang

Kentucky Transportation Center Presentations

No abstract provided.

A Unified Framework For Calculation Of Surrogate Safety Metrics For Autonomous Vehicles In Work Zones, Marcus Putz, Sean Brennan

Kentucky Transportation Center Presentations

No abstract provided.

Multivariate Model Of Road Crashes For Vulnerable Users, Jonathan Agüero-Valverde, Darío Vargas Aguilar

Kentucky Transportation Center Presentations

No abstract provided.

Equitable Roadways: Analyzing Rural-Urban Road Safety In Nevada For Informed Strategic Planning, Khandaker Arafin Islam, Shashi Nambisan

Kentucky Transportation Center Presentations

No abstract provided.

Unintended Consequences: Changes In Driver Behavior Associated With The Adoption Of Advanced Driver Assistance Systems, Nischal Gupta, Peter T. Savolainen

Kentucky Transportation Center Presentations

Advanced driver assistance systems (ADAS) are a disruptive precursor to fully autonomous vehicles (AVs), which will have far-reaching impacts on the nature of travel. With various ADAS features becoming increasingly common in vehicles, some unintended changes in driving behavior are expected including engaging in more risk-taking behavior while driving. To that end, the present study utilizes survey-based data of 1,000 Michigan adults and investigates the likelihood of drivers engaging in three different driving behaviors- cell phone use, consumption of alcohol, and tailgating when driving a vehicle with collision alert systems by means of multivariate ordered probit regression analysis. Results showed …

Making The Most Of What You Have: Data To Optimize Space And Achieve Research Goals, Paul Leef

Research Analytics Summit 2024

Every institution has a strategic goal for more research funding and results. The drive for funding is inextricably tied to competition for top researchers, and competition for researchers is directly related to investments in and optimization of research space on university campuses. The case for focusing on space is critical when you expect each lab to produce $1 million or more in expenditures every 4 years. How can you use data analytics to optimize space allocation for research? How can you creatively use under-utilized spaces for short- and long-term research investments? This session will discuss Carnegie R2 and R1 and …

Introducing A ‘Research Impact Roadmap’ In A Young University: Challenges And Opportunities, Roopa Rajashekar

Research Analytics Summit 2024

‘Research Impact’ as a defined concept is expanding and garnering more attention globally. What was once positioned more narrowly and often confused with basic outcomes reporting has since risen to a primary focus for sponsor agencies across all stages of R&D. Hence, building a comprehensive research impact framework provides a critical map for universities to strengthen the R&D ecosystems in which it engages in innumerable ways.

Khalifa University of Science and Technology (KU), located in Abu Dhabi, UAE, is a relatively a young university, by Times Higher Education definition). Even so, KU ranked 238 in the QS World University Rankings …

The Impact Of Dissolved Organic Matter On Photodegradation Rates, Byproduct Formations, And Degradation Pathways For Two Neonicotinoid Insecticides In Simulated River Waters, Josephus F. Borsuah, Tiffany L. Messer, Daniel D. Snow, Steven D. Comfort, Shannon Bartelt-Hunt

UK CARES Faculty Publications

The influences of dissolved organic matter (DOM) on neonicotinoid photochemical degradation and product formation in natural waters remain unclear, potentially impacting the sustainability of river systems. Therefore, our overall objective was to investigate the photodegradation mechanisms and phototransformation byproducts of two neonicotinoid pesticides, imidacloprid and thiamethoxam, under simulated sunlight at the microcosm scale, to assess the implications of DOM for insecticide degradation in rivers. Direct and indirect photolysis were investigated using twelve water matrices to identify possible reaction pathways with two DOM sources and three quenching agents. Imidacloprid, thiamethoxam, and potential degradants were measured, and reaction pathways identified. The photodegradation …

Flexible Attenuation Fields: Tomographic Reconstruction From Heterogeneous Datasets, Clifford S. Parker

Theses and Dissertations--Computer Science

Traditional reconstruction methods for X-ray computed tomography (CT) are highly constrained in the variety of input datasets they admit. Many of the imaging settings -- the incident energy, field-of-view, effective resolution -- remain fixed across projection images, and the only real variance is in the detector's position and orientation with respect to the scene. In contrast, methods for 3D reconstruction of natural scenes are extremely flexible to the geometric and photometric properties of the input datasets, readily accepting and benefiting from images captured under varying lighting conditions, with different cameras, and at disparate points in time and space. Extending CT …

Profiles Of Satisfaction And Frustration Of Undergraduate General Chemistry Students’ Basic Psychological Needs At The Beginning And End Of The Semester, Cara E. Worick

Theses and Dissertations--Educational, School, and Counseling Psychology

The early college years represent an adjustment period characterized by motivational destabilization and academic and career-related uncertainty for many STEM majors (Robinson et al., 2019). Although students who begin college less academically prepared than their peers are at greater risk of struggling in introductory STEM courses, many still struggle in these courses despite adequate academic preparation (Perez et al., 2014). Self-determination theory proposes that motivation, optimal functioning, and psychological well-being occur through the satisfaction, as opposed to the frustration, of three basic psychological needs for autonomy, competence, and relatedness (Ryan & Deci, 2020). Although many studies in educational settings demonstrate …

Beer, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

A 3-Step, Open-Data, Ride-Hailing Ridership Model With Pricing Applications, Richard A. Mucci

Theses and Dissertations--Civil Engineering

Researchers and practitioners studied the effects ride-hailing had in cities before the covid-19 pandemic. Previous research found ride-hailing to produce negative externalities, such as reducing transit ridership and increasing congestion in various cities. Since the pandemic, ride-hailing ridership has nearly recovered to pre-pandemic levels in Chicago. Ride-hailing ridership has grown steadily since the pandemic while a rider’s willingness to share their trip stagnated. Ride-hailing ridership nearly recovering to pre-covid levels in Chicago suggests that transportation planners, and policy makers, will need to continue assessing the impacts ride-hailing trips have in their cities.

Pickup and drop off locations in the Chicago …

Post-Capture Synthesis Of Images Using Manipulable Integration Functions, Paul Eberhart

Theses and Dissertations--Computer Science

Traditional photographic practice, as dictated by the properties of photochemical emulsion film, mechanical apparatus, and human operators, largely treats the sensitivity (gain) and integration interval as coarsely parameterized constants for the entire scene, set no later than the time of exposure. This frame-at-a-time capture and processing model permeates digital cameras and computer image processing. Emerging imaging technologies, such as time domain continuous imaging (TDCI), quanta image sensors (QIS), event cameras, and conventional sensors augmented with computational processing and control, provide opportunities to break out of the frame-oriented paradigm and capture a stream of data describing changes to scene appearance over …

"And I / Am The Arrow": The Narrative, Personae Construction, And Language Ideology Of Confessional Poets' Identity Performance, Madison Fuchs

Theses and Dissertations--Linguistics

This thesis argues for consideration of linguistic features in service of raising the postmodern confessionalist poet identity as an utterance and an act of loyalty to performance. The embodiment of the confessionalist identity, attributed to the features used to adhere to the confessional mode, is realized through the invention of confessional personae. These confessional personae merge the responsibilities of the speaker and the narrator to convey a pseudo-autobiographical utterance to a designated audience. In this thesis, I analyze a sequence of poems that either possess taboo subjects or utilize linguistic functions, like indexicality and audience design, that mark its mode. …

Effect Of Admixtures On Rapid Hardening, Self-Consolidating Concrete, Haley Johnson

Theses and Dissertations--Civil Engineering

Self-consolidating, rapid-hardening concrete is a sought-after product in the market now, however the effects of admixtures on fresh and hardened concrete rheology are still uncertain. This study aims to create a self-consolidating concrete (SCC) using calcium sulfoaluminate (CSA) cement for its rapid-hardening properties, and tests two set time retarders and two viscosity-modifying admixtures (VMAs) to determine how they affect the properties of concrete. The properties studied in this thesis are workability, viscosity, set times, air content, compressive strength, and freeze-thaw resistance of self-consolidating concrete. It was found that tartaric acid creates a very workable SCC with consistent results regardless of …

Quantitative Sustainable Design Of Urban Tree Soil Cells For Stormwater Management, Jamaya Wilson

Theses and Dissertations--Civil Engineering

Urban trees are critical assets to cities around the world. They act as a green infrastructure system to provide various environmental, economic and social benefits to their surrounding environments. However, the quality of life of urban trees is severely threatened by uncontrolled urbanization and climate change. The compaction of urban soils to meet the structural stability requirements for buildings and pavements directly restricts tree growth. Soil cells are green infrastructure placed in tree wells to transfer active and static loads to pavements. This allows for reduced soil compaction and increased tree root expansion. However, because the technology is still in …

Understanding The Construction Workforce Needs Of The Future: Technology, Skills, Diversity, Bassam Ramadan

Theses and Dissertations--Civil Engineering

The U.S. construction industry stands at a crossroads. The looming age cliff is about to present its most serious challenges yet, coinciding with a shortage of qualified skilled professionals. As the demands of the construction industry continue to grow, it continues to lack the manpower to meet those demands. In order to meet the rising demands of construction needs in the near future, the construction industry needs to focus on improving workforce performance and productivity, and increasing the size of the construction labor force. Existing research highlights the importance of technological adoption and workforce skills, and that gender and ethnic …

Detailed Report On The Measurement Of The Positive Muon Anomalous Magnetic Moment To 0.20 Ppm, Muon G − 2 Collaboration

Physics and Astronomy Faculty Publications

We present details on a new measurement of the muon magnetic anomaly, aμ=(gμ-2)/2. The result is based on positive muon data taken at Fermilab's Muon Campus during the 2019 and 2020 accelerator runs. The measurement uses 3.1 GeV/c polarized muons stored in a 7.1-m-radius storage ring with a 1.45 T uniform magnetic field. The value of aμ is determined from the measured difference between the muon spin precession frequency and its cyclotron frequency. This difference is normalized to the strength of the magnetic field, measured using nuclear magnetic resonance. The ratio is then corrected for small contributions from beam motion, …

The Present And Future Of Qcd, P. Achenbach

Physics and Astronomy Faculty Publications

This White Paper presents an overview of the current status and future perspective of QCD research, based on the community inputs and scientific conclusions from the 2022 Hot and Cold QCD Town Meeting. We present the progress made in the last decade toward a deep understanding of both the fundamental structure of the sub-atomic matter of nucleon and nucleus in cold QCD, and the hot QCD matter in heavy ion collisions. We identify key questions of QCD research and plausible paths to obtaining answers to those questions in the near future, hence defining priorities of our research over the coming …

Wine, Other, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Mineral, Spring, Table, And Bottled Water, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Wine, Red, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Wine, White, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Increasing Awareness Of Implicit Bias And Systemic Racism Among Clinical Staff Caring For Non-Hispanic Black Maternal Patients, Melissa Courtney

DNP Projects

Background: Kentucky is ranked 17^th in the nation for the highest maternal mortality rate in the U.S. with a rate of 22.9 per 100,000, and 78 percent of those maternal deaths were considered preventable. The Non-Hispanic Black maternal death rate in the U.S. and Kentucky is 2.9 times higher than that of the Non-Hispanic White maternal counterparts (Kentucky Department of Public Health Division of Maternal and Child Health (KDPHDMCH), 2022). The fundamental cause of maternal health inequities is structural racism, which leads to poor treatment and experiences in the healthcare system (Chinn et al., 2020). Structural racism and implicit …

Research Analytics Maturity Model & Herd: Transforming Tomorrow By Using Data To Drive Decisions, Baron Wolf, Katherine Leung Robershaw

Research Analytics Summit 2024

No abstract provided.