Digital Commons Network^™

Investigation Of Succinylated Zwitterionic Polyethylenimine/Dna Complexes: Performance In Serum, Internalization, And Intracellular Fate, Levi Lampe

Theses and Dissertations--Chemical and Materials Engineering

Gene therapy has promised to revolutionize medicine since the earliest clinical trials, but a lack of delivery methods that are both safe and efficient has hampered progress. Gene therapy with viral vectors is effective at delivering nucleic acids to cells, but is associated with dangerous immunogenic responses and cancer-causing insertions into the genome. Viral vectors are also among the most prohibitively costly therapeutics in medicine. Polymeric vectors avoid these dangers and are made from inexpensive, off-the- shelf materials, but have been hindered by poor efficiency compared to viral vectors.

A benchmark polymer for in vitro nucleic acid delivery has been …

Navigating Mental Wellness: A Peer-Led Journey Into Adult Services, Kristin G. Haberek

DSW Capstone Projects

Students with severe emotional disturbances (SED) occupy one of the most underserved intersections in American education and mental health care. As they age out of children’s services, they face abrupt service discontinuation, disrupted therapeutic relationships, and adult systems ill-equipped to meet their needs. These vulnerabilities, including heightened risks of crisis, hospitalization, homelessness, and justice involvement, constitute a central practice problem. This capstone addresses these transitions across three scholarly products: a systematic literature review, a theoretical concept paper, and a practical application paper, tracing a unified arc from diagnosing structural failures to proposing an evidence-informed, equity-oriented clinical response. Synthesizing key findings …

Student Familiarity With The Periodic Table Of The Elements: Results From Cued-Recall And Eye-Tracking Assessments On Memory, Victor A. Okuo

Theses and Dissertations--Chemistry

Learning element symbol–name associations and the spatial organization of elements on the periodic table is a foundational step in learning chemistry, supporting later understanding of chemical formulas, equations, bonding, and stoichiometry. Although students often rely on memorization strategies to learn periodic table content, this task is challenging due to the large number of elements and the apparent ambiguity in matching some element symbols to their names.

This study explores students’ recall of element names when given element symbols as cues and their knowledge of element locations on the periodic table when given element names as cues. The study also examines …

Daily Rhythms In Psychosocial Stress, Sleep, And Mood: A Multimethod Approach To Transdiagnostic Psychopathology Risk And Intervention, Gabriel Gilmore

Theses and Dissertations--Psychology

Rhythms are central to nearly every core physiological and psychological process and have profound influences on overall health and well-being, particularly in the context of mood disorders. This dissertation emphasizes a rhythm-centered framework for understanding transdiagnostic psychopathology, proposing that the temporal organization of psychosocial stress, sleep, and mood provides crucial information for the development and treatment of mood disorder symptomology. Current literature relies primarily on mean symptom levels, overlooking day-to-day patterns in psychosocial experiences. To address this key methodological gap, three studies are examined. Study 1 develops and validates the Psychosocial Stress Regularity Measure (PSRM), a brief single-item measure of …

Numerical Modeling Of Multi-Scale Jet Feedback In Seyfert Galaxies, Julianne Goddard

Theses and Dissertations--Physics and Astronomy

We present a suite of high-resolution cosmological zoom-in simulations investigating the impact of mechanical and thermal feedback from low-luminosity jets launched from supermassive black holes (SMBHs) on Seyfert galaxy evolution from early cosmic times to the present (z ≤ 10). Our models follow the formation of central galaxies within identical dark matter halos of logMhalo/M⊙ ∼ 11.8 at z = 0, seeded with ∼ 10^6M⊙ SMBHs at z ∼ 9.1 and z ∼ 3.7. Feedback from active galactic nuclei (AGN) is implemented in the form of bipolar jets launched along the SMBH spin axis, with jet powers spanning Ljet ∼ …

The Making Of Modern Kentucky, Melanie Beals Goan

Open Educational Resources

Kentucky has always been something of an enigma, never fitting neatly into regional categories of north, east, south, or west. It is a borderland, and its unique blend of glitz and glamour juxtaposed with its rough and wild reputation continue to make it a place that is hard to pin down. Designed for college students, both those born here and those who are making the state their temporary home, this book provides an introduction to Kentucky's history, moving beyond simplistic stereotypes to consider the forces that have shaped its development over more than two centuries.

The book can also be …

The Impossible Motherhood: Education Accompanying Mothers (Peidu Mama) And Transnational Migration In China’S Global Era, Jingxue Zhang Dr.

Theses and Dissertations--Gender and Women's Studies

This dissertation examines transnational educational relocation as a gendered project of future making through the figure of Chinese educational accompanying mothers, or peidu mama, in Chiang Mai, Thailand, and the Greater Los Angeles area in the United States. It investigates how educational migration is organized through the intersection of affective governance, moralized motherhood, and unequal global conditions. It seeks to answer how transnational educational motherhood is represented in state-endorsed media and public discourse; how women narrate and justify educational relocation while negotiating the morally unstable label of peidu mama; how aspiration, risk, and the idea of “a better …

H2 Matrix Compression For Fast Magnetic Field Post-Processing, Calvin M. Demps

University of Kentucky Master's Theses

Large-scale computational electromagnetic simulations frequently require the assembly of dense system matrices, whose computation time and memory cost grow rapidly with problem size and can render high-resolution simulations impractical. This thesis presents a benchmark of the H² hierarchical matrix method applied to the construction of a coupling matrix that maps magnetization current in a structure to the magnetic field at observation points external to the structure. The underlying field interaction is derived from Maxwell's equations and discretized using a Nyström approach, producing a dense matrix.

The method is benchmarked across various geometries of increasing complexity and for increasing mesh …

Preserving Large-Scale Railroad Infrastructure Sites: The Louisville And Nashville Ravenna Yard As A Case Study, Zachary Jones

Graduate Final Projects

This project consists of a draft National Register of Historic Places (NRHP) nomination for the Ravenna Louisville and Nashville Railyard, located in Irvine, Kentucky. Developed in the early twentieth century as the operational center of the L&N Railroad’s Eastern Kentucky Division, the rail yard played a significant role in the transportation of coal and other natural resources while contributing to the growth of the towns of Ravenna and Irvine. Through the review of historical resources, field documentation, and examination of preservation scholarship, this project evaluates the historical significance and integrity of the surviving rail yard resources and argues for their …

Examining Marginalized Sexual Identity Development Through Perry’S Scheme Of Cognitive Development, Miranda Bejda

University of Kentucky Doctoral Dissertations

Existing models of LGBTQ+ sexual identity development are critiqued for their linearity and lack of inclusion for diverse experiences and sexual identities. There is a call for a more robust understanding of the cognitive aspect of sexual identity development. The purpose of this dissertation is to further the understanding of how people think about their sexual identity through the developmental process using Perry’s scheme of cognitive development as a framework. Through semi-structured interviews, I analyze the LGBTQ+ sexual identity development process (Stage 1), how Perry’s scheme applies to LGBTQ+ sexual identity development (Stage 2), and propose a Perry-informed model of …

Multiscale Modeling Of The Thermomechanical Behavior Of Polymeric And Molecular Organic Semiconductors, Kehinde H. Fagbohungbe

University of Kentucky Doctoral Dissertations

Organic semiconductors, derived from π-conjugated polymers and molecules, enable the development of deformable, stretchable and flexible electronics due to their tunable redox, optical, electronic and mechanical properties. However, an informed understanding of how multi-scale morphological characteristics of the polymeric and molecular semiconductors influence bulk properties that contribute to electronic and optical performance, especially under operational thermal and mechanical stresses, remains incomplete. This lack of understanding poses a challenge to scalability and commercialization of organic electronics. This dissertation develops and deploys computational modeling approaches, particularly atomistic molecular dynamics (MD) simulations, to investigate the multiscale morphological behavior of these synthetic semiconducting materials …

Non-Invasive Digital Restoration Of Damaged Photographic Film Negatives, Ankan Bhattacharyya

University of Kentucky Doctoral Dissertations

Physical restoration of damaged photographic film causes more damage. Also, existing non-invasive digital restoration of film negatives does not produce print-quality optical images. Instead, they produce X-ray projections, which are not the same as optical projections. This thesis addresses these problems and establishes a framework that can digitally restore old, damaged films without the need to open them physically. Virtual Unwrapping is an existing pipeline that has proven itself over the last couple of decades to work on unopenable papyrus scrolls, like the Herculaneum Scrolls. This thesis utilizes the concept of virtual unwrapping to restore damaged photographic film negatives. Due …

An Ethical Analysis Of International Graduate Student Workers' (Igsws) Employment Vulnerability, Adeola F. Oladeji

University of Kentucky Doctoral Dissertations

International graduate student workers (IGSWs) occupy a distinctive position within U.S. higher education as students, employees, and temporary visa holders. Their academic progress, financial support, and legal authorization to remain in the United States are often closely intertwined, creating dependencies that heighten their vulnerability to exploitation, unequal treatment, and institutional power imbalances. Although previous scholarship has documented these challenges from empirical, legal, and policy perspectives, comparatively little attention has been given to universities' ethical responsibilities toward IGSWs.

This dissertation examines how U.S. higher education institutions should fulfill their ethical responsibilities to international graduate student workers. Grounded in Dewey's pattern of …

Contractual Democracy From Statehouse To School Board: Shifts In Legislation And School Board Authority In Kentucky, Hannah M. Edelen

University of Kentucky Doctoral Dissertations

School boards have long been regarded as a cornerstone of American democracy, providing local governance over public education. While considerable scholarship highlights the increasing involvement of state and federal governments in education, relatively few studies examine with specificity how legislatures shape the local authority of these governance structures. This study investigates how the Kentucky State Legislature has influenced the authority of local school boards over three legislative sessions (2020–2022) and how board members perceive their evolving role. Using a multi-method approach and conceptualized in principal-agent theory, this research contributes to understanding how legislatures shape the governing responsibilities of school boards …

Impact Of West Virginia Abortion Ban On West Virginia Physician Trainee Practice Intentions, Rebecca Wald, Kristy Ward, Sarah Dotson

Journal of Appalachian Health

In June 2022, the Dobbs v Jackson Women’s Health Organization overturned the constitutional right to abortion established by Roe vs. Wade. Shortly after, West Virginia (WV) began enforcing a near total ban on abortion. Statewide restrictions on access to reproductive health care have important implications for the recruitment and retention of physicians. This project aimed to determine overall awareness of the 2022 changes in abortion laws among physician trainees, and whether the law influenced the intention of resident/fellow physicians to practice medicine in the state following completion of their medical training. A total of 178 resident and fellow physicians at …

Becoming Steve Bright, Robert L. Tsai

Kentucky Law Journal

No abstract provided.

¿Cómo Se Dice, "Liberty And Justice For All Cannot Exist Without Equal Access For All" En Español?, Turner Denise Reynolds

Kentucky Law Journal

No abstract provided.

Like Balance On Ice: Towards A New Approach To The Open And Obvious Doctrine Under Kentucky Law, Hayden T. Crosby

Kentucky Law Journal

No abstract provided.

Just A Place Or A Just Place?: Domestic Violence, Urban-Rural Differences, And Access To Justice, Cassie Chambers Armstrong

Kentucky Law Journal

No abstract provided.

Prosecutorial Discretion And Digital Democracy, Erin Sheley

Kentucky Law Journal

No abstract provided.

Founder Worship, Effective Altruism, And Corporate Governance, Jennifer S. Fan, Xuan-Thao Nguyen

Kentucky Law Journal

No abstract provided.

Gene Expression Profile–Based Test To Predict Melanoma Sentinel Node Status, Tina J. Hieken, Michael E. Egger, Christina V. Angeles, John R. Hyngstrom, Erin E. Burke, Michael C. Lowe, Georgia M. Beasley, Edmund K. Bartlett, Scott C. Bresler, Kelly L. Harms, Jonathan S. Zager, Julia S. Lehman, Nabil Wasif, Sanjay P. Bagaria, Kelly M. Mcmasters, David A. Wada, Prakash Pandalai, Keith A. Delman, Jay Lee, Klaus J. Busam, Jane L. Messina, Vernon K. Sondak

Surgery Faculty Publications

Importance Contemporary guidelines recommend sentinel lymph node biopsy (SLNB) for patients with melanoma with predicted risk of SLN metastasis greater than 10% and consideration of SLNB when the risk is 5% to 10%. A gene expression profile (GEP)–based test that can accurately identify patients with a low risk of SLN metastasis would refine selection for SLNB. Objective To establish the predictive capability of the combined clinicopathological factors and GEP (CP-GEP) test to identify patients with primary cutaneous melanoma who can safely forgo SLNB and to investigate the prognostic value of CP-GEP regarding the outcome in patients with cutaneous melanoma after …

Development Of A Kytc Highway Geometric Design Workshop, Jill Asher, Jeff Jasper, Travis Thompson, Chris Van Dyke

Kentucky Transportation Center Research Report

In-depth knowledge of geometric design principles is a prerequisite for delivering road projects that provide safe and efficient multimodal mobility for all users. Historically, Kentucky Transportation Cabinet (KYTC) early-career design staff arrived at the agency with little design experience. The agency has relied on a combination of short courses and mentorship provided by experienced personnel to bring early-career design staff up to speed on design best practices. However, this approach to training carries limitations. Employee turnover and imposing workloads make it challenging for early- and even mid-career design professionals to receive guidance from seasoned designers who have long tenures at …

Redistricting, Gerrymandering, And Graham V. Adams: It's Time For An Independent Redistricting Commission In Kentucky, Kathleen Dudgeon

Kentucky Law Journal

No abstract provided.

"Blocking Out The Haters:" Government Officials Create Split Among Federal Judiciary, Andrew Weisgerber

Kentucky Law Journal

No abstract provided.

The Next Generation, Jeremiah Chin

Kentucky Law Journal

No abstract provided.

New Challenges To Judicial Federalism, James A. Gardner

Kentucky Law Journal

No abstract provided.

Governors Slightly More Bound? A Critique Of The Uniform Law Commission's Model Public-Health Emergency Authority Act, Paul A. Diller

Kentucky Law Journal

No abstract provided.

The Wages Of Hitching Wagons, Thomas B. Bennett

Kentucky Law Journal

No abstract provided.

Courting Jural Rights: The Kentucky Constitution And The Super Common Law Of Torts, Sarah L. Swan

Kentucky Law Journal

No abstract provided.