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Gene Expression Barcode Values Reveal A Potential Link Between Parkinson's Disease And Gastric Cancer, Suyan Tian, Shishun Zhao, Mingbo Tang, Chi Wang Feb 2021

Gene Expression Barcode Values Reveal A Potential Link Between Parkinson's Disease And Gastric Cancer, Suyan Tian, Shishun Zhao, Mingbo Tang, Chi Wang

Internal Medicine Faculty Publications

Gastric cancer is a disease that develops from the lining of the stomach, whereas Parkinson's disease is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. Although these two diseases seem to be distinct from each other, increasing evidence suggests that they might be linked. To explore the linkage between these two diseases, differentially expressed genes between the diseased people and their normal controls were identified using the barcode algorithm. This algorithm transforms actual gene expression values into barcode values comprised of 1's (expressed genes) and 0's (silenced genes). Once the overlapped differentially expressed …


Genetic Analysis Of Selfed And Open Pollinated Progenies Of Stylosanthes Capitata, Rosangela M. S. Resende, M. D. V. Resende, Liana Jank, Lucimara Chiari, Cacilda B. Valle Feb 2021

Genetic Analysis Of Selfed And Open Pollinated Progenies Of Stylosanthes Capitata, Rosangela M. S. Resende, M. D. V. Resende, Liana Jank, Lucimara Chiari, Cacilda B. Valle

IGC Proceedings (1977-2023)

No abstract provided.


Establishment And Growth Of Tall Fescue (Festuca Arundinacea) Cultivars With Spring Sowing In Southern Australia, Zhongnan Nie, B. Clark Feb 2021

Establishment And Growth Of Tall Fescue (Festuca Arundinacea) Cultivars With Spring Sowing In Southern Australia, Zhongnan Nie, B. Clark

IGC Proceedings (1977-2023)

No abstract provided.


Aberrant Azin2 And Polyamine Metabolism Precipitates Tau Neuropathology, Leslie A. Sandusky-Beltran, Andrii Kovalenko, Devon S. Placides, Kevin Ratnasamy, Chao Ma, Jerry B. Hunt, Huimin Liang, John Ivan T. Calahatian, Camilla Michalski, Margaret Fahnestock, Laura J. Blair, April L. Darling, Jeremy D. Baker, Sarah N. Fontaine, Chad A. Dickey, Joshua J. Gamsby, Kevin R. Nash, Erin L. Abner, Maj-Linda B. Selenica, Daniel C. Lee Feb 2021

Aberrant Azin2 And Polyamine Metabolism Precipitates Tau Neuropathology, Leslie A. Sandusky-Beltran, Andrii Kovalenko, Devon S. Placides, Kevin Ratnasamy, Chao Ma, Jerry B. Hunt, Huimin Liang, John Ivan T. Calahatian, Camilla Michalski, Margaret Fahnestock, Laura J. Blair, April L. Darling, Jeremy D. Baker, Sarah N. Fontaine, Chad A. Dickey, Joshua J. Gamsby, Kevin R. Nash, Erin L. Abner, Maj-Linda B. Selenica, Daniel C. Lee

Sanders-Brown Center on Aging Faculty Publications

Tauopathies display a spectrum of phenotypes from cognitive to affective behavioral impairments; however, mechanisms promoting tau pathology and how tau elicits behavioral impairment remain unclear. We report a unique interaction between polyamine metabolism, behavioral impairment, and tau fate. Polyamines are ubiquitous aliphatic molecules that support neuronal function, axonal integrity, and cognitive processing. Transient increases in polyamine metabolism hallmark the cell’s response to various insults, known as the polyamine stress response (PSR). Dysregulation of gene transcripts associated with polyamine metabolism in Alzheimer’s disease (AD) brains were observed, and we found that ornithine decarboxylase antizyme inhibitor 2 (AZIN2) increased to …


Physical Mapping Of The Anopheles (Nyssorhynchus) Darlingi Genomic Scaffolds, Míriam Silva Rafael, Leticia Cegatti Bridi, Igor V. Sharakhov, Osvaldo Marinotti, Maria V. Sharakhova, Vladimir A. Timoshevskiy, Giselle Moura Guimarães-Marques, Valéria Silva Santos, Carlos Gustavo Nunes Da Silva, Spartaco Astolfi-Filho, Wanderli Pedro Tadei Feb 2021

Physical Mapping Of The Anopheles (Nyssorhynchus) Darlingi Genomic Scaffolds, Míriam Silva Rafael, Leticia Cegatti Bridi, Igor V. Sharakhov, Osvaldo Marinotti, Maria V. Sharakhova, Vladimir A. Timoshevskiy, Giselle Moura Guimarães-Marques, Valéria Silva Santos, Carlos Gustavo Nunes Da Silva, Spartaco Astolfi-Filho, Wanderli Pedro Tadei

Biology Faculty Publications

The genome assembly of Anopheles darlingi consists of 2221 scaffolds (N50 = 115,072 bp) and has a size spanning 136.94 Mbp. This assembly represents one of the smallest genomes among Anopheles species. Anopheles darlingi genomic DNA fragments of ~37 Kb were cloned, end-sequenced, and used as probes for fluorescence in situ hybridization (FISH) with salivary gland polytene chromosomes. In total, we mapped nine DNA probes to scaffolds and autosomal arms. Comparative analysis of the An. darlingi scaffolds with homologous sequences of the Anopheles albimanus and Anopheles gambiae genomes identified chromosomal rearrangements among these species. Our results confirmed that physical mapping …


Carbon Isotope Discrimination, Selection Response, And Forage Production Of Tall Fescue In Contrasting Environments, R. C. Johnson, Andrew A. Hopkins, M. A. Evans Feb 2021

Carbon Isotope Discrimination, Selection Response, And Forage Production Of Tall Fescue In Contrasting Environments, R. C. Johnson, Andrew A. Hopkins, M. A. Evans

IGC Proceedings (1977-2023)

No abstract provided.


Selection Of Panicum Maximum Genotypes Under Different Shade Levels, Liana Jank, M. M. Gontijo Neto, V. A. Laura, Rosangela M. S. Resende, Cacilda Borges Do Valle Feb 2021

Selection Of Panicum Maximum Genotypes Under Different Shade Levels, Liana Jank, M. M. Gontijo Neto, V. A. Laura, Rosangela M. S. Resende, Cacilda Borges Do Valle

IGC Proceedings (1977-2023)

No abstract provided.


Development Of Improved Wheatgrasses For The Southern Great Plains Of The Usa, Andrew A. Hopkins Feb 2021

Development Of Improved Wheatgrasses For The Southern Great Plains Of The Usa, Andrew A. Hopkins

IGC Proceedings (1977-2023)

No abstract provided.


The Development Of Talish Clover (Trifolium Tumens Steven Ex M. Bieb.) As A Potential New Perennial Pasture Legume For Low Rainfall Temperate Environments, Eric J. Hall, A. M. Hurst Feb 2021

The Development Of Talish Clover (Trifolium Tumens Steven Ex M. Bieb.) As A Potential New Perennial Pasture Legume For Low Rainfall Temperate Environments, Eric J. Hall, A. M. Hurst

IGC Proceedings (1977-2023)

No abstract provided.


Dactylis Glomerata Ssp. Hispanica (Roth) Nyman, Cultivars Uplands And Sendace, Drought Tolerant Forage Grasses For Temperate Environments, Eric J. Hall, P. A. Lane, A. M. Hurst Feb 2021

Dactylis Glomerata Ssp. Hispanica (Roth) Nyman, Cultivars Uplands And Sendace, Drought Tolerant Forage Grasses For Temperate Environments, Eric J. Hall, P. A. Lane, A. M. Hurst

IGC Proceedings (1977-2023)

No abstract provided.


Germplasm Improvement In Pasture Legumes By Developing Core Collections, K. Ghamkhar, R. Snowball, M. Ryan, Ph. Nichols, R. Appels Feb 2021

Germplasm Improvement In Pasture Legumes By Developing Core Collections, K. Ghamkhar, R. Snowball, M. Ryan, Ph. Nichols, R. Appels

IGC Proceedings (1977-2023)

No abstract provided.


Techniques For Artificial Hybridization In The Self‐Pollinated Forage Legume Bituminaria Bituminosa And The Cross‐Pollinated Forage Legume Hedysarum Coronarium, D. Real, K. Foster, Enrique Correal, D. Kidd, P. Mendez Feb 2021

Techniques For Artificial Hybridization In The Self‐Pollinated Forage Legume Bituminaria Bituminosa And The Cross‐Pollinated Forage Legume Hedysarum Coronarium, D. Real, K. Foster, Enrique Correal, D. Kidd, P. Mendez

IGC Proceedings (1977-2023)

No abstract provided.


Establishment Of Perennial Forage Crops Using Fast‐Growing Short‐Lived Grasses As Companion Crops, Bruce E. Coulman, Cheryl Duncan, Tim Nelson, Arend Kleinhout Feb 2021

Establishment Of Perennial Forage Crops Using Fast‐Growing Short‐Lived Grasses As Companion Crops, Bruce E. Coulman, Cheryl Duncan, Tim Nelson, Arend Kleinhout

IGC Proceedings (1977-2023)

No abstract provided.


The Forage Selection Program At The Cerrados Research Center--33 Years Of Contributions For The Tropics, Marcelo A. Carvalho, Claudio T. Karia, A. O. Barcellos, G. G. Leite, Lourival Vilela, Allan K. B. Ramos, Francisco Duarte Fernandes, S. V. Paula-Moraes, G. B. Martha Júnior, R. Guimarães Júnior Feb 2021

The Forage Selection Program At The Cerrados Research Center--33 Years Of Contributions For The Tropics, Marcelo A. Carvalho, Claudio T. Karia, A. O. Barcellos, G. G. Leite, Lourival Vilela, Allan K. B. Ramos, Francisco Duarte Fernandes, S. V. Paula-Moraes, G. B. Martha Júnior, R. Guimarães Júnior

IGC Proceedings (1977-2023)

No abstract provided.


Immunomodulatory Effects Of Azithromycin Revisited: Potential Applications To Covid-19, Vincent J. Venditto, Dalia Haydar, Ahmed K. Abdel-Latif, John C. Gensel, Michael I. Anstead, Michelle G. Pitts, Jarrod W. Creameans, Timothy J. Kopper, Chi Peng, David J. Feola Feb 2021

Immunomodulatory Effects Of Azithromycin Revisited: Potential Applications To Covid-19, Vincent J. Venditto, Dalia Haydar, Ahmed K. Abdel-Latif, John C. Gensel, Michael I. Anstead, Michelle G. Pitts, Jarrod W. Creameans, Timothy J. Kopper, Chi Peng, David J. Feola

Pharmaceutical Sciences Faculty Publications

The rapid advancement of the COVID-19 pandemic has prompted an accelerated pursuit to identify effective therapeutics. Stages of the disease course have been defined by viral burden, lung pathology, and progression through phases of the immune response. Immunological factors including inflammatory cell infiltration and cytokine storm have been associated with severe disease and death. Many immunomodulatory therapies for COVID-19 are currently being investigated, and preliminary results support the premise of targeting the immune response. However, because suppressing immune mechanisms could also impact the clearance of the virus in the early stages of infection, therapeutic success is likely to depend on …


Tiller Development Of Three Bromegrass (Bromus) Species Following Defoliation, Biligetu, B. E. Coulman Feb 2021

Tiller Development Of Three Bromegrass (Bromus) Species Following Defoliation, Biligetu, B. E. Coulman

IGC Proceedings (1977-2023)

No abstract provided.


Heritability And Genetic Correlations Of Forage Yield Traits In Alfalfa (Medicago Sativa L.) For Central Valley Of Mexico, B. Alarcon‐Zuniga, R. Perdomo‐Gomez Feb 2021

Heritability And Genetic Correlations Of Forage Yield Traits In Alfalfa (Medicago Sativa L.) For Central Valley Of Mexico, B. Alarcon‐Zuniga, R. Perdomo‐Gomez

IGC Proceedings (1977-2023)

No abstract provided.


Genetic Diversity Of Hemarthria Compressa Germplasm In Southwest China Detected By Issr Markers, Fang Li, Yan Fan, Xinquan Zhang, Xiao Ma Feb 2021

Genetic Diversity Of Hemarthria Compressa Germplasm In Southwest China Detected By Issr Markers, Fang Li, Yan Fan, Xinquan Zhang, Xiao Ma

IGC Proceedings (1977-2023)

No abstract provided.


Agrobacterium‐Mediated Genetic Transformation Of Elymus Breviaristatus With Pseudomonas Pseudoalcaligenes Insecticidal Protein Gene, Daxu Li, Shiqie Bai, Gang Liu, Minghong You Feb 2021

Agrobacterium‐Mediated Genetic Transformation Of Elymus Breviaristatus With Pseudomonas Pseudoalcaligenes Insecticidal Protein Gene, Daxu Li, Shiqie Bai, Gang Liu, Minghong You

IGC Proceedings (1977-2023)

No abstract provided.


Improvement Of Forage Grass Quality For Future Climate And Agricultural Demands, C. S. Jensen, T. Didion, G. Gadegaard, I. Lenk, C. Gao, M. Folling, R. Sabroe, K. K. Nielsen Feb 2021

Improvement Of Forage Grass Quality For Future Climate And Agricultural Demands, C. S. Jensen, T. Didion, G. Gadegaard, I. Lenk, C. Gao, M. Folling, R. Sabroe, K. K. Nielsen

IGC Proceedings (1977-2023)

No abstract provided.


Metabolic Response Of Lolium Perenne To Drought Stress, Heike Hahn, J. Kopka, Oliver Fiehn, B. Scott Feb 2021

Metabolic Response Of Lolium Perenne To Drought Stress, Heike Hahn, J. Kopka, Oliver Fiehn, B. Scott

IGC Proceedings (1977-2023)

No abstract provided.


The Comparative Psychology Of Intelligence: Macphail Revisited, Michael Colombo, Damian Scarf, Thomas R. Zentall Feb 2021

The Comparative Psychology Of Intelligence: Macphail Revisited, Michael Colombo, Damian Scarf, Thomas R. Zentall

Psychology Faculty Publications

No abstract provided.


Nutrients Intake By The Ile‐De‐France Lambs Fed Up With Diets Containing Sugar Cane Forage Variety Or Corn Silage, A. G. Silva Sobrinho, G. M. B. Moreno, A. G. Leão, C. M. B. Loureiro, A. A. M. Sampaio Feb 2021

Nutrients Intake By The Ile‐De‐France Lambs Fed Up With Diets Containing Sugar Cane Forage Variety Or Corn Silage, A. G. Silva Sobrinho, G. M. B. Moreno, A. G. Leão, C. M. B. Loureiro, A. A. M. Sampaio

IGC Proceedings (1977-2023)

No abstract provided.


So42- Uptake And Its Assimilation In The Different Genotypes Of Rape On The S‐Deficient, Lushen Li, Yulan Jin, Bok-Rye Lee, Woo-Jin Jung, Tae-Hwan Kim Feb 2021

So42- Uptake And Its Assimilation In The Different Genotypes Of Rape On The S‐Deficient, Lushen Li, Yulan Jin, Bok-Rye Lee, Woo-Jin Jung, Tae-Hwan Kim

IGC Proceedings (1977-2023)

No abstract provided.


Problems Of Grass Feed Quality Providing And Its Influence On Animals Health, Baiba Osmane, Aleksandrs Jemeljanovs, Jānis Blūzmanis Feb 2021

Problems Of Grass Feed Quality Providing And Its Influence On Animals Health, Baiba Osmane, Aleksandrs Jemeljanovs, Jānis Blūzmanis

IGC Proceedings (1977-2023)

No abstract provided.


Use Of By‐Products Derived From Neem Tree (Azadirachta Indica) In Livestock Production, W. Z. Yang, B. N. Ametaj Feb 2021

Use Of By‐Products Derived From Neem Tree (Azadirachta Indica) In Livestock Production, W. Z. Yang, B. N. Ametaj

IGC Proceedings (1977-2023)

No abstract provided.


Fodder Availability And Nutritive Value Of Two Sahelian Browse Plants: Acacia Senegal And Pterocarpus Lucens, H. O. Sanon, F. Ouattara, I. Ledin Feb 2021

Fodder Availability And Nutritive Value Of Two Sahelian Browse Plants: Acacia Senegal And Pterocarpus Lucens, H. O. Sanon, F. Ouattara, I. Ledin

IGC Proceedings (1977-2023)

No abstract provided.


Machine Intelligence Identifies Soluble Tnfa As A Therapeutic Target For Spinal Cord Injury, J. R. Huie, A. R. Ferguson, N. Kyritsis, J. Z. Pan, K.-A. Irvine, J. L. Nielson, P. G. Schupp, M. C. Oldham, John C. Gensel, A. Lin, M. R. Segal, R. R. Ratan, J. C. Bresnahan, M. S. Beattie Feb 2021

Machine Intelligence Identifies Soluble Tnfa As A Therapeutic Target For Spinal Cord Injury, J. R. Huie, A. R. Ferguson, N. Kyritsis, J. Z. Pan, K.-A. Irvine, J. L. Nielson, P. G. Schupp, M. C. Oldham, John C. Gensel, A. Lin, M. R. Segal, R. R. Ratan, J. C. Bresnahan, M. S. Beattie

Spinal Cord and Brain Injury Research Center Faculty Publications

Traumatic spinal cord injury (SCI) produces a complex syndrome that is expressed across multiple endpoints ranging from molecular and cellular changes to functional behavioral deficits. Effective therapeutic strategies for CNS injury are therefore likely to manifest multi-factorial effects across a broad range of biological and functional outcome measures. Thus, multivariate analytic approaches are needed to capture the linkage between biological and neurobehavioral outcomes. Injury-induced neuroinflammation (NI) presents a particularly challenging therapeutic target, since NI is involved in both degeneration and repair. Here, we used big-data integration and large-scale analytics to examine a large dataset of preclinical efficacy tests combining five …


Copper Oxide Nanoparticle Diameter Mediates Serum-Sensitive Toxicity In Beas-2b Cells, Angie S. Morris, Brittany E. Givens, Aaron Silva, Aliasger K. Salem Feb 2021

Copper Oxide Nanoparticle Diameter Mediates Serum-Sensitive Toxicity In Beas-2b Cells, Angie S. Morris, Brittany E. Givens, Aaron Silva, Aliasger K. Salem

Chemical and Materials Engineering Faculty Publications

Copper oxide (CuO) nanoparticles (NPs) are abundant in manufacturing processes, but they are an airway irritant. In vitro pulmonary toxicity of CuO NPs has been modeled using cell lines such as human bronchial epithelial cell line BEAS-2B. In 2D in vitro culture, BEAS-2B undergoes squamous differentiation due to the presence of serum. Differentiation is part of the repair process of lung cells in vivo that helps to preserve the epithelial lining of the respiratory tract. Herein, the effects of serum on the hydrodynamic diameter, cellular viability, cellular differentiation, and cellular uptake of 5 and 35 nm CuO NPs are investigated, …


Dna Repair Pathways In Cancer Therapy And Resistance, Lan-Ya Li, Yi-Di Guan, Xi-Sha Chen, Jin-Ming Yang, Yan Cheng Feb 2021

Dna Repair Pathways In Cancer Therapy And Resistance, Lan-Ya Li, Yi-Di Guan, Xi-Sha Chen, Jin-Ming Yang, Yan Cheng

Toxicology and Cancer Biology Faculty Publications

DNA repair pathways are triggered to maintain genetic stability and integrity when mammalian cells are exposed to endogenous or exogenous DNA-damaging agents. The deregulation of DNA repair pathways is associated with the initiation and progression of cancer. As the primary anti-cancer therapies, ionizing radiation and chemotherapeutic agents induce cell death by directly or indirectly causing DNA damage, dysregulation of the DNA damage response may contribute to hypersensitivity or resistance of cancer cells to genotoxic agents and targeting DNA repair pathway can increase the tumor sensitivity to cancer therapies. Therefore, targeting DNA repair pathways may be a potential therapeutic approach for …