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1,2-Diamination Of Alkenes Via Reduction Of 1,2,3-Triazolinium Ions, Setareh Saryazdi

Theses and Dissertations--Chemistry

1,2-Diamine substructures are prevalent functional motifs in natural products, pharmaceutical compounds, and ligands. The interesting functionalities of 1,2-diamines have inspired many synthetic chemists to design various methodologies for preparing these structures from simple precursors such as alkenes. In this work, we described two different but related methods using simple and easily accessible reagents for 1,2-diamination of alkenes. In the first method, an alkene undergoes 1,3-dipolar cycloaddition with an organic azide to form a 1,2,3-triazoline. Subsequent N-alkylation of the generated 1,2,3-triazoline gives the 1,2,3-triazolinium ion, which is then hydrogenated over Raney Ni with a balloon of H₂ to produce …

Cell-Engineered Vesicles For Therapeutic Delivery And Immunomodulatory Applications, Khaga Neupane

Theses and Dissertations--Chemistry

Development of a new kind of drug delivery system (DDS) that could efficiently deliver therapeutics to the cell of interest would allow us to accomplish cell-specific drug delivery while eliminating systemic toxicity. Although nanocarriers including endogenously released extracellular vesicles (EEVs), liposomes, and small molecules seem to be promising drug delivery systems, biological challenges persist for their use in clinical applications. Here, we demonstrate nanovesicles engineered by fragmenting cellular membranes can be exploited as versatile DDSs for therapeutics delivery as well as immunomodulatory functions. Cell-engineered vesicles were produced by cavitating cells using nitrogen gas at high pressure followed by serial centrifugation. …

Healthcare Equity For Transgender Individuals, Mollie Staggs

DSW Capstone Projects

In the field of social justice and integrity, Social Work has dedicated itself to improving the welfare of the world, in which we all participate and interact. There are countless issues in our society that warrant professional attention for the fundamental purpose of positively impacting the livelihood of subcategories of people. For this particular Capstone Project, the focus is on transgender individuals’ systemic healthcare barriers that cisgender people within the United States do not similarly experience. The purpose is to unveil these disparities to then pose progressive alterations within the healthcare system to make the navigation and accessibility better for …

Bolstering The Effectiveness Of Exposure-Response Prevention In The Treatment Of Obsessive-Compulsive Disorder: Using Self-Compassion As An Adjunctive Intervention, Whitney E. Dyer

DSW Capstone Projects

Individuals suffering with Obsessive-Compulsive Disorder (OCD) face many challenges receiving proper diagnostics and evidence-based treatment. Furthermore, Exposure-Response Prevention (ERP), the empirically supported gold standard approach for targeting OCD, presents its own challenges. Examining the influences of ERP treatment reluctance is paramount to bolstering the effectiveness of outcomes and safeguarding participant adherence and ultimate success. This Capstone highlights the overlooking of addressing shame within traditional ERP protocol and posits a practice application model that supports the adjunctive use of self-compassion, a potent antidote for shame, within the use of ERP. As treatment hesitation is an inhibitor to relief for OCD sufferers, …

Assessing The Temporal Relationship Between Changes In Neuroticism And Symptom Improvement In The Unified Protocol, Nicole Stumpp

Theses and Dissertations--Psychology

Neuroticism is defined as the tendency to experience frequent and intense negative emotions accompanied by the belief that one could not cope adequately in response to stress. Neuroticism is associated with the development and maintenance of a range of emotional disorders (e.g., anxiety disorders, depression) and targeting this trait in treatment (rather than symptoms) may represent a more efficient approach to care. However, researchers have rarely measured neuroticism and symptoms frequently enough to establish temporal precedence between these dimensions. The present study is a secondary analysis that examined the temporal relationship between neuroticism and anxiety and depressive symptoms during a …

Examining The Impact Of Discrete And Contextual Stress Factors On Memory, Jillian Rae Silva-Jones

Theses and Dissertations--Psychology

Stress is a complex and multifaceted process which is often not perceived as such. Therefore, given the unidimensional conceptualization of stress in previous research the current understanding of the associations between stress and memory are not well understood. This study investigates the association between stress and memory by capturing the complexity of stress through discrete and contextual stress factors. The current study used ecological momentary assessment (EMA) and geocoded indices (i.e., zip codes) of population density (i.e., urbanicity) and deprivation (socioeconomic disadvantage) in a large and diverse sample of U.S. participants (N = 8817) to examine the relationship between …

Assessing Stress Biomarkers As Embodied Identity In Kentucky’S Green River Archaic, Anna-Marie Casserly

Theses and Dissertations--Anthropology

The primary goal of this bioarchaeology dissertation research is to investigate the relationship between evidence of social identity and indicators of biological stress in the Green River region of Kentucky during the Late Archaic period (5,000-3,000 BP). Utilizing a biocultural perspective, I examine the ways that aspects of identity and social organization are embodied through the experience of biological stress. This research explores how social differences influence the patterning of osteological stress markers in an Archaic population while problematizing categories of difference that are often naturalized in bioarchaeology, such as gender or age cohorts. In so doing, it contributes to …

‘I Went To The One Game In Town’: Obstetric And Maternity Unit Closures, Dwindling Birth Choices, And Resilience In Rural Appalachia, Sia Beasley

Theses and Dissertations--Anthropology

Obstetric and maternity health services are being rapidly eliminated in the rural United States, making maternal care more difficult to access and causing negative birth outcomes. Service closures have a magnified impact in Appalachia due to histories of systemic regional and state policy practices which devalue the lives of people living rural areas, local economic marginalization, geographic barriers, and insufficient health infrastructures. This research investigates how women living in rural Appalachia navigate pregnancy and birth amidst constant care closures. The Sunflower Mountain Region is a seven-county area in rural Southern Appalachia. The region has experienced ongoing obstetric closures over the …

Peer-Induced Cocaine Seeking In Rats: Comparison To Nonsocial Stimuli And Role Of Paraventricular Hypothalamic Oxytocin Neurons, Lindsey R. Hammerslag, Bree A. Humburg, Samantha G. Malone, Joshua S. Beckmann, Kathryn E. Saatman, Valery Grinevich, Michael T. Bardo

Psychology Faculty Publications

The purpose of this study was to determine if social vs nonsocial cues (peer vs light/ tone) can serve as discriminative stimuli to reinstate cocaine seeking. In addition, to assess a potential mechanism, an oxytocin (OT) promoter-linked hM3Dq DREADD was infused into the paraventricular nucleus of the hypothalamus to determine whether peer-induced cocaine seeking is decreased by activation of OT neurons. Male rats underwent twice-daily self-administration sessions, once with cocaine in the presence of one peer (S+) and once with saline in the presence of a different peer (S-). Another experiment used similar procedures, except the discriminative stimuli were nonsocial …

Etiology Of Firefighter Injuries: A Health Care Practitioner Perspective, Alyssa Quinn Eastman

Theses and Dissertations--Kinesiology and Health Promotion

BACKGROUND: Structural firefighting involves the performance of rigorous occupational tasks in unpredictable, dynamic, and hot environments which increases firefighters’ risk of injury. Specifically, the National Fire Protection Association reported that musculoskeletal injuries account for 56% of non-fireground and 41% of fireground injuries. Furthermore, physical training is the most common cause of injury, accounting for one-third of all injuries and resulting in 41% of post-injury absences from work. There is limited research identifying occupational and exercise injury risk factors among firefighters. However, experienced health care practitioners working with fire departments may provide critical insight into potential mechanisms of these common injuries. …

Long Term Observation Of The Grassland Vegetation Used Intensively Or Extensively And Ecologically, H.-D. Matthes, J. Matthes, W. Jentsch, V. Pastushenko

IGC Proceedings (1977-2023)

The aim of the present paper was to study alterations of the grassland flora from 55 plots following a more extensive management under long term observation within 6 years. Extensification of grassland use leads to an increase of the numbers of plant species by 32%, “Red-list-species” included. The moisture number of the soils slightly increased and the reaction and nitrogen numbers decreased. Results are presented for different vegetation units.

Influence Of Extensive Management On Botanical Composition Of Permanent Meadow Sward, K. Mlynarczyk, E. Korona, E. Marks

IGC Proceedings (1977-2023)

The aim of undertaken investigations was to find the possibilities of grassland management with special respect to the biodiversity and the landscape conservation. Changes in botanical composition of the meadow sward against a background of different mowing utilization were examined on the semi-natural meadows situated on the peat-mursh soil in Masurian Landscape Park (north-east Poland). The areas mown with biennial pause and completely turned off from uses followed gradual simplifying of species composition and increasing of bog species participation. Results show on advisability of passing one harvest each year or with one-year pauses.

Vegetation Changes In Sown Grassland In The Uk After Nine Years Of Extensive Grazing Management, C. A. Marriott, G. T. Barthram

IGC Proceedings (1977-2023)

The effect of extensive grazing management with sheep on vegetation change in sown pastures (initially containing Lolium perenne and Trifolium repens) in the uplands of Scotland was investigated from 1990-1999. One treatment was representative of current more intensive management systems; it was fertilized, and maintained at a sward surface height of 4 cm. Two treatments were unfertilized and were maintained at sward surface heights of 4 cm or 8 cm; the ewe numbers carried on these treatments averaged 74% and 44%, respectively, of those on the fertilized treatment. In all treatments the sheep were Scottish Blackface ewes. Their single …

The Influence Of Rising Atmospheric Co2 On Grassland Ecosystems, J. A. Morgan, P. C. D. Newton, J. Nösberger, C. E. Owensby

IGC Proceedings (1977-2023)

Increasing atmospheric CO₂ concentrations and climatic change will have significant effects on the ecology of grasslands. This paper evaluates results from four CO₂ enrichment studies in contrasting grasslands. A Swiss study investigates the effects of elevated CO₂ (600 μL L^-1 CO₂) on perennial ryegrass (Lolium perenne L.) and white clover (Trifolium repens L), a New Zealand study examines how elevated CO₂ (475 μL L^-1 CO₂) affects a botanically diverse pasture, and studies in the Kansas tallgrass prairie and the Colorado shortgrass steppe investigate the effects of an approximate …

Elevated Co2 Enhances Productivity And The C/N Ratio Of Grasses In The Colorado Shortgrass Steppe, J. A. Morgan, A. R. Mosier, D. R. Lecain, W. J. Parton, D. G. Milchunas

IGC Proceedings (1977-2023)

Atmospheric CO₂ concentrations have been increasing since the industrial revolution, and are projected to double within this century over today's concentration of 360 µmol mol^-1 . This study used six open-top chambers in the Colorado, USA shortgrass steppe to investigate how increasing CO₂ will affect productivity and C and N status of indigenous perennial grasses and forbs. From March until October, chambers were placed on two plots in each of the three blocks. In each block, one chamber was assigned an ambient CO₂ treatment (~360 µmol mol^-1), the other an elevated CO₂ treatment …

Rangeland Desertification In China, Wang Tao

IGC Proceedings (1977-2023)

Land desertification is one of the most serious environmental and social-economic problems in the North China. The processes of desertification mainly have being controlled by the interaction of human activities and fragile eco-environment, that means the pattern and intension of landuse are major factors for development or reverse of desertification. Because of the increasing pressure of population, the rangeland in the North China has being cultivated decade by decade, which changed landuse from grassing to cropping in a large area and destroyed the natural vegetation cover. The result is to let the wind erosion become easier and the desertification has …

Grasslands, Communicating The Benefits, D. Keeney

IGC Proceedings (1977-2023)

The multiple benefits of perennial agriculture , including forages and grasslands, for building soil quality, protection of natural resources, enhancement of biodiversity and wildlife, are well known to us, but little understood by the public. This is not a situation where “more education” would necessarily increase recognition. Rather, we must build in the public a desire for the enhancement of green space, clean water and air, and diverse landscapes that multiple purpose agriculture can bring. We seek such environments intuitively and now that much of the world’s people are “trapped” in urban settings of steel and concrete, this desire is …

Single-Cell Analysis Of Aneurysmal Aortic Tissue In Patients With Marfan Syndrome Reveals Dysfunctional Tgf-Β Signaling, Ashley Dawson, Yanming Li, Yang Li, Pingping Ren, Hernan G. Vasquez, Chen Zhang, Kimberly R. Rebello, Waleed Ageedi, Alon R. Azares, Aladdein Burchett Mattar, Mary Burchett Sheppard, Hong S. Lu, Joseph S. Coselli, Lisa A. Cassis, Alan Daugherty, Ying H. Shen, Scott A. Lemaire

Saha Cardiovascular Research Center Faculty Publications

The molecular and cellular processes leading to aortic aneurysm development in Marfan syndrome (MFS) remain poorly understood. In this study, we examined the changes of aortic cell populations and gene expression in MFS by performing single-cell RNA sequencing (scRNA seq) on ascending aortic aneurysm tissues from patients with MFS (n = 3) and age-matched non-aneurysmal control tissues from cardiac donors and recipients (n = 4). The expression of key molecules was confirmed by immunostaining. We detected diverse populations of smooth muscle cells (SMCs), fibroblasts, and endothelial cells (ECs) in the aortic wall. Aortic tissues from MFS showed alterations …

Phenological And Social Characterization Of Three Lasioglossum (Dialictus) Species Inferred From Long-Term Trapping Collections, Lyllian A.-J. Corbin, David N. Awde, Miriam H. Richards

Entomology Faculty Publications

Detailed social and phenological data collected from nesting aggregations exist for relatively few sweat bee species because nesting aggregations are rarely found in large numbers, even when local populations are highly abundant. This limits researchers’ abilities to assess the social status of many species, which in turn, limits our ability to trace the sequence of evolutionary steps between alternative social states. To address this problem, we demonstrate the utility of rehydrated, pinned specimens from pan trap and netting collections for generating inferences about the phenology and social status of a well-studied sweat bee species, Lasioglossum (Dialictus) laevissimum. …

Agropastoral Systems An Alternative To Revert Pasture Degradation In The Cerrados Of Brazil: Preliminary Results, Manuel C. M. Macedo, J. A. M. Bono, A. H. Zimmer, F. P. Costa, Tsutomu Kanno, Cesar Heraclides Behling Miranda, A. N. Kichel

IGC Proceedings (1977-2023)

A long term experiment was set to test the hypothesis that agropastoral systems could improve crop and animal production, being more profitable and sustainable relative to economical, biological and environmental aspects, than continuous and traditional crop and grazing pasture systems. Five farming systems are being tested: two traditional (continuous soybean annual cropping and continuous pasture cropping) and three agropastoral systems (two combinations of four by four years of rotational crop-pasture systems and one by three years of crop-pasture rotation). Animal production in continuous pasture cropping measured as liveweight gain/ha (LWG) are declining along the years in the sub-treatment without fertilizer …

Evaluation Of A Number Of Grass Species For Restoring Degraded Semi-Arid Rangelands In Southern Africa, K. Kellner, S. De Wet

IGC Proceedings (1977-2023)

The biophysical environment is an important determinant of land degradation in both commercial and communal land tenure systems in South Africa. According to a recent study on the status of land degradation, approximately 25% of the total land cover in South Africa is degraded. Several technologies exist to restore the soil and vegetation degraded areas in natural pastures. To improve the production and biodiversity potential for agricultural and conservation uses in these rangelands, a common restoration technology includes the cultivation the eroded and compacted soil surfaces by rip- ploughing and the re-vegetation with high productive, palatable and perennial species. Five …

Water-Use Efficiency And Infiltration Under Different Rangeland Conditions And Cultivation In A Semi-Arid Climate Of South Africa, Hennie A. Snyman

IGC Proceedings (1977-2023)

The objective of this study was to determine the impact of rangeland in different botanical composition classes (good, moderate and poor), on water-use efficiency (WUE: crude protein produced per unit of evapotranspiration) and soilwater content. The same measurements were also made on an undisturbed bare soil surface and soil cultivated twice per annum. Evapotranspiration was determined by quantifying the soil-water balance equation with the aid of runoff plots and soil-water content measurements done by a neutron hydroprobe. Water-use efficiency declined significantly (P ≤ 0.01) with rangeland degradation. Rangeland in good condition averaged a WUE of 0.28 kg crude protein ha …

Community Structure Of Serrated Tussock (Nassella Trichotoma) Infested Grasslands, Warwick B. Badgery, David R. Kemp, D. L. Michalk, W. Mcg. King

IGC Proceedings (1977-2023)

Serrated tussock (Nassella trichotoma) is the most serious perennial grass weed in southeastern Australia, extending over more than a million hectares. Previous control techniques using herbicides and oversowing with competitive pastures are no longer feasible in many of the lower fertility, infested areas. New management solutions need to be found, based upon a better understanding of the ecology of this species. A survey was done to determine the community structure of serrated tussock infested grasslands. Winter growing C3 grasses were closely associated with serrated tussock, while C4 perennial grasses appeared not to be. It is not known if …

Valuing The Pasture Resource - Importance Of Perennials In Higher Rainfall Regions Of South Eastern Australia, P. M. Dowling, R. E. Jones, David R. Kemp, D. L. Michalk

IGC Proceedings (1977-2023)

The premature decline of perennial grass based pastures in southern temperate Australia results in poor productivity and unstable pastures that allow invasion by less desirable weedy species and the potential for soil degradation. The loss of perennial species is attributed to overgrazing arising from an undervaluation of the pasture resource. Resowing pastures is largely uneconomic so maintenance of, or increasing the perennial, is dependent on improved grazing and pasture management practices. A key to changing perceptions is valuing the true worth of the perennial component. Results are presented from a model that takes into account the seasonality of production of …

Using ‘Traps’ (Transect Recording And Processing System) In Woody Weed Control Studies In Australia, P. V. Back

IGC Proceedings (1977-2023)

The ‘TRAPS’ (Transect Recording And Processing System) methodology has proven to be a powerful and versatile tool for studying the effects of various woody weed control strategies in studies carried out in Queensland, Australia. ‘TRAPS’ allows the tracking of individual woody plants even when destructive control techniques such as bulldozing, ploughing and burning are used. This methodology also allows the investigator to discriminate between plants present before any treatment is imposed and plants recruited after the treatment.

Importance Of Haresfoot Clover (Trifolium Arvense) As A Nitrogen Fixer In Semi-Arid Grasslands Of New Zealand, C. C. Boswell, W. L. Lowther, P. R. Espie

IGC Proceedings (1977-2023)

The aim of the study was to determine the distribution of annual haresfoot clover (Trifolium arvense) in a depleted indigenous short tussock grassland catchment in the dry subhumid MacKenzie Basin, South Island, New Zealand. Haresfoot clover was present on all landscapes, and widely distributed on lower sunny aspects, suggesting that it is an important component of the nitrogen cycle in these environments even in the absence of fertiliser application. The study was conducted during an atypically moist summer when a bloom of the annual clover occurred. Nitrogen inputs will vary with landscape and spring/summer rainfall and it is …

The Future For Savanna And Tropical Grasslands: A Latin American Perspective, R. R. Vera

IGC Proceedings (1977-2023)

The objective of the paper is to briefly review the main trends in the tropical lowlands of Latin America and the Caribbean (LAC) with particular emphasis in the neotropical savannas. These tropical native grasslands cover occupy approximately 210 million hectares, and constitute major portions of the territory of Bolivia, Brazil, Colombia, Guyana and Venezuela. Many analysts consider that intensification of their use is a valid alternative to the expansion of the livestock and crop industries into the rainforest.

The evidence reviewed shows that since the late 1980s, the LAC agricultural sector has shown dynamism not seen for many years. Despite …

Ecophysiology And Management Response Of The Subtropical Grasslands Of Southern South America, E. J. Berretta

IGC Proceedings (1977-2023)

The subtropical grasslands of Southern South America (campos) are located approximately in the range of 24° S to 37° S latitude. These grasslands are dominated by C₃ and C₄ grasses, and in a lesser extent to herbaceous plants, shrubs and dispersed trees, with some exceptions in particular regions. Previous to the introduction of large herbivores, at the beginning of the XVII century, like cattle and horses, shrubs and tall grasses dominated the vegetation. Then, associated with greater grazing pressure and partially due to fire, the original campos are maintained, actually in a pseudo-climax herbaceous phase. These native communities …

Goats To Control The Encroachment Of Undesirable Brush And Woody Species In Cattle Pastures, J-M. Luginbuhl, J. T. Green Jr., M. H. Poore, A. C. Conrad

IGC Proceedings (1977-2023)

Field studies were initiated in an abandoned, overgrown 8.4 ha orchard left untouched for 15 years to evaluate the effectiveness of using goats (Capra hircus hircus) to manage undesirable vegetation. Goats alone (G: 30 does/ha) or cattle (Bos taurus) with goats (GC:17 does/ha and 3 steers/ha) were mob-grazed twice a year during four grazing seasons. Multiflora rose (Rosa multiflora Thunb.) canopy area decreased from 12 to 2.5 m² in grazed pastures and multiflora rose live canes were 100% in the control, 0% in G, and only 8% in GC at the completion of the …

Herbaceous Vegetation Dynamic After Cut And Burn Shrub Plants In Southern Brazil, A. M. Girardi-Deiro, M. L. Porto, J. Riboldi

IGC Proceedings (1977-2023)

A savanna area at "Serra do Sudeste" in southern Brazil, was studied during four years to evaluate the influence of cutting and burning shrub plants on dynamic of herbaceous vegetation. The cover of each species in 44 permanent quadrats (0,25 m²) and in each area (cut and burned) was evaluated. The results suggested that grasses and legumes were favored by cutting shrub plants. Burning favored forbs in the first years after disturbance and retarded the development of native forage species desirable for grazing.