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Articles 1831 - 1860 of 18111
Full-Text Articles in Entire DC Network
Natural And Artificial Drying Effects On Condensed Tannins Of Sericea Lespedeza, T H. University Of Georgia, W R. Windham, J J. Evans, C S. Hoveland
Natural And Artificial Drying Effects On Condensed Tannins Of Sericea Lespedeza, T H. University Of Georgia, W R. Windham, J J. Evans, C S. Hoveland
IGC Proceedings (1977-2023)
Sericea lespedeza [Lespedeza cuneata (Dumont-Cours.) G. Don.] is well adapted to acid soils and low fertility but has generally been considered a low-quality forage due to high levels of tannin and indigestible fiber. Tannin levels increase during midsummer (Windham et al. 1988). The most commonly used assay for tannin in sericea is the vanillin-HCl procedure (Burns, 1963) on oven-dried samples. Oven-drying has been reported to cause increased polymerization or oxidative changes in tannins (Goldstein and Swain, 1963). Fresh-frozen sericea contained higher amounts of extractable tannin than field-dried forage and fiber digestibility of high-tannin sericea by sheep was much lower …
Impact Wv: Adapting Patient Navigation Models Of Care To Improve Services To Caregivers Of Infants Exposed To Substances In Utero, Charlotte S. Workman Bsms, Ccrp, Lesley Cottrell, Mawyah Bashatah, Aisha Hashmi, Kayla Richard, Poornima Murthy, Susan Harrison, Ashleigh Mckinsey, Amy Bott, Sydney Leary, Cody Smith, Melina Danko
Impact Wv: Adapting Patient Navigation Models Of Care To Improve Services To Caregivers Of Infants Exposed To Substances In Utero, Charlotte S. Workman Bsms, Ccrp, Lesley Cottrell, Mawyah Bashatah, Aisha Hashmi, Kayla Richard, Poornima Murthy, Susan Harrison, Ashleigh Mckinsey, Amy Bott, Sydney Leary, Cody Smith, Melina Danko
Journal of Appalachian Health
Patient navigation (PN) is a healthcare service delivery model designed to partner clients with service providers to reduce challenges to health care, as well as to improve access to care by identifying opportunities to coordinate services for clients. The IMPACT WV project at the West Virginia University Center for Excellence in Disabilities (WVU CED) implemented PN models of care for caregivers of infants exposed to substances in utero. The purpose of this program was to reduce burden for potentially at-risk families and improve caregiver and infant outcomes as a result. To understand the processes that influence the implementation of PN …
Determinants Of Willingness To Share Wearable Health Data With Health Care Providers In Appalachian Populations: An Exploratory Study, Gilbert Munoz Cornejo, Joonghee Lee
Determinants Of Willingness To Share Wearable Health Data With Health Care Providers In Appalachian Populations: An Exploratory Study, Gilbert Munoz Cornejo, Joonghee Lee
Journal of Appalachian Health
Background: Wearable health devices capture metrics (e.g., physical activity, ECG, sleep) that can enhance care when shared with providers. Yet, willingness to share wearable data may differ in Appalachia, where chronic disease burdens, mistrust, and limited infrastructure pose unique challenges.
Objective: This study explored (1) which sociodemographic, health, and digital behaviors correlate with willingness to share wearable data and (2) how these insights can guide region-specific interventions in Appalachia.
Methods: We analyzed 320 Appalachian respondents from the Health Information National Trends Survey (HINTS 6). Descriptive statistics and logistic regression models examined willingness to share wearable data. Because of small cell …
Fentanyl Test Strip Use And Overdose Risk Reduction Behaviors Among People Who Use Drugs, Rachel A Vickers-Smith, Kitty H Gelberg, Janet E Childerhose, Denise C Babineau, Redonna Chandler, James L David, Lauren D'Costa, Megan Dzurec, Barry Eggleston, Amanda Fallin-Bennett, Laura C Fanucchi, Soledad Fernandez, Jace Gilbert, Louisa Gilbert, Megan E Hall, Brooke E Hiltz, Michael W Konstan, Kathryn E Lancaster, Beth Linas, Katherine R Marks, Nichole Michaels, Jennifer Miles, Fernando Montero, Haley J Ramsey Harden, Carter Roeber, Mary R Russo, Rachel Taylor, Melissa A Theis
Fentanyl Test Strip Use And Overdose Risk Reduction Behaviors Among People Who Use Drugs, Rachel A Vickers-Smith, Kitty H Gelberg, Janet E Childerhose, Denise C Babineau, Redonna Chandler, James L David, Lauren D'Costa, Megan Dzurec, Barry Eggleston, Amanda Fallin-Bennett, Laura C Fanucchi, Soledad Fernandez, Jace Gilbert, Louisa Gilbert, Megan E Hall, Brooke E Hiltz, Michael W Konstan, Kathryn E Lancaster, Beth Linas, Katherine R Marks, Nichole Michaels, Jennifer Miles, Fernando Montero, Haley J Ramsey Harden, Carter Roeber, Mary R Russo, Rachel Taylor, Melissa A Theis
Epidemiology and Environmental Health Faculty Publications
IMPORTANCE: Illegal fentanyl is driving overdose mortality, and fentanyl test strips (FTS) can be used to test drugs for fentanyl at the point of consumption. Evidence on whether FTS use is associated with overdose risk reduction behaviors is encouraging, but largely limited to smaller, single-site studies.
OBJECTIVE: To determine whether self-reported baseline FTS use among people who use drugs (PWUD) was associated with overdose risk reduction behaviors and nonfatal overdose over a 28-day follow-up.
DESIGN, SETTING, AND PARTICIPANTS: Multisite, observational cohort study of PWUD conducted from May to December 2023 as an ancillary study of the HEALing Communities Study, which …
Introducing Social Determinants Of Health To The Alzheimer's Disease Research Center Network, Megan Zuelsdorff, Erin L. Abner, Joyce E. Balls-Berry, Gregory A. Jicha, Serggio Lanata, Gladys E. Maestre, Monica Rosselli, Shana D. Stites, Rachel A. Whitmer, Consuelo H. Wilkins, Lisa L. Barnes
Introducing Social Determinants Of Health To The Alzheimer's Disease Research Center Network, Megan Zuelsdorff, Erin L. Abner, Joyce E. Balls-Berry, Gregory A. Jicha, Serggio Lanata, Gladys E. Maestre, Monica Rosselli, Shana D. Stites, Rachel A. Whitmer, Consuelo H. Wilkins, Lisa L. Barnes
Epidemiology and Environmental Health Faculty Publications
The Alzheimer's Disease Research Centers (ADRCs) consortium represents a critical locus of research on Alzheimer's disease and related disorders (ADRD) prevention, diagnosis, and intervention. Through the National Alzheimer's Coordinating Center's (NACC) standardized protocol, the Uniform Data Set (UDS), ADRCs have collected rich, harmonizable clinical and cognitive data. However, the collection of social data has been sparse and Center specific, constraining ADRD science that addresses research priorities on social determinants of health (SDOH) and health equity. Capitalizing on the transition to a revised UDS version 4, an interdisciplinary committee representing 10 ADRCs reviewed the literature and instrumentation, ultimately creating a brief …
Genetic Identification Of Lamprey Genera And Anadromous Ecotypes In Watersheds Of The Northeastern Pacific Ocean, G. S. Silver, R. T. Lampman, N. Percival, N. Timoshevskaya, J. J. Smith, K. T. Bentley, J. Wade, S. R. Narum, J. E. Hess
Genetic Identification Of Lamprey Genera And Anadromous Ecotypes In Watersheds Of The Northeastern Pacific Ocean, G. S. Silver, R. T. Lampman, N. Percival, N. Timoshevskaya, J. J. Smith, K. T. Bentley, J. Wade, S. R. Narum, J. E. Hess
Biology Faculty Publications
Nonparasitic, nonmigratory Western Brook Lamprey (WBL; Lampetra ayresii), and parasitic, anadromous Western River Lamprey (WRL; L. ayresii) are sympatric lampreys that likely represent different life history variations of a single species. Novel genetic tools are critical for differentiating WBL and WRL, whose larvae preclude morphological identification (ID) and will enable comprehensive assessment of imperiled native lampreys of the Northeastern Pacific (including WBL, WRL, and Pacific Lamprey, Entosphenus tridentatus). We developed 47 candidate single nucleotide polymorphism (SNP) markers using whole genome resequencing of WBL (N = 24) and WRL (N = 15) from Ksi Ts'oohl Ts'ap Creek (Nass River, British Columbia, …
Resistance Exercise And Mechanical Overload Upregulate Vimentin For Skeletal Muscle Remodeling, Joshua S. Godwin, J. Max Michel, Cleiton A. Libardi, Andreas N. Kavazis, Christopher S. Fry, Andrew D. Frugé, Mariah Mccashland, Ivan J. Vechetti, John J. Mccarthy, C. Brooks Mobley, Michael D. Roberts
Resistance Exercise And Mechanical Overload Upregulate Vimentin For Skeletal Muscle Remodeling, Joshua S. Godwin, J. Max Michel, Cleiton A. Libardi, Andreas N. Kavazis, Christopher S. Fry, Andrew D. Frugé, Mariah Mccashland, Ivan J. Vechetti, John J. Mccarthy, C. Brooks Mobley, Michael D. Roberts
Physiology Faculty Publications
We adopted a proteomic and follow-through approach to investigate how mechanical overload (MOV) potentially affects novel targets in skeletal muscle, and how a perturbation in this response could potentially affect the adaptive response. First, we determined that 10 wk of resistance training in 15 college-aged females increased sarcolemmal-associated protein content (+10.1%, P < 0.05). Sarcolemmal protein isolates were then queried using mass spectrometry-based proteomics, ∼10% (38/387) of proteins putatively associated with the sarcolemma or extracellular matrix (ECM) were upregulated (>1.5-fold, P < 0.05), and one target (intermediate filament vimentin; VIM) warranted further investigation due to its correlation to myofiber hypertrophy (r = 0.652, P = 0.009). VIM expression was then examined in 4-mo-old C57BL/6J mice following 10 and 20 days of plantaris MOV via synergist ablation. Relative to Sham (control) mice, VIM mRNA and protein content was significantly higher in MOV mice, and immunohistochemistry indicated that VIM predominantly resided in the ECM. MOV experiments were replicated in Pax7-DTA (satellite cell depleted) mice, which reduced VIM in the ECM by ∼74%. A third MOV experiment was performed in C57BL/6 mice intramuscularly injected with either AAV9-scrambled (control) or AAV9-VIM-shRNA. Although VIM-shRNA mice possessed lower VIM in the ECM (∼45%), plantaris masses in response to MOV were similar between groups. However, VIMshRNA mice possessed smaller and more centrally nucleated MyHCemb-positive fibers in response to MOV. In summary, skeletal muscle VIM appears to be enriched in the ECM following MOV, satellite cells may regulate its expression, and a disruption in expression during MOV leads to an excessive regenerative phenotype.
Therapeutic Applications Of A Novel Humanized Monoclonal Antibody Targeting Chemokine Receptor Ccr9 In Pancreatic Cancer, Hannah G. Mcdonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash Pandalai, Mautin Barry-Hundeyin, Megan Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca-Lema, Elia Álvarez-Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim
Therapeutic Applications Of A Novel Humanized Monoclonal Antibody Targeting Chemokine Receptor Ccr9 In Pancreatic Cancer, Hannah G. Mcdonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash Pandalai, Mautin Barry-Hundeyin, Megan Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca-Lema, Elia Álvarez-Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim
Markey Cancer Center Faculty Publications
The relative failure of immune checkpoint inhibitors in pancreatic ductal adenocarcinoma (PDAC) despite having a dense, immunosuppressive tumor microenvironment highlights the need to target alternate/escape pathways. We have previously examined C–C chemokine receptor type 9 (CCR9) as a candidate immune checkpoint and developed a targeted, humanized monoclonal antibody (SRB2). Cytotoxicity of SRB2 was evaluated in vitro and in vivo. CCR9 expression on PDAC cells/tissues, immune components of patient-derived organoids (PDOs), and antibody-dependent cell-mediated cytotoxicity were examined. In PANC-1 and MIA PaCa-2 cell lines, we demonstrated highest CCR9 expression; however, no direct cytotoxic effect was observed with SRB2 treatment. In PANC-1 …
An Agrin-Yap/Taz Rigidity Sensing Module Drives Egfr-Addicted Lung Tumorigenesis., Reza Bayat Mokhtari, Divyaleka Sampath, Paige Eversole, Melissa Ong Yu Lin, Dmitriy A. Bosykh, Gandhi T. K. Boopathy, Aravind Sivakumar, Cheng-Chun Wang, Ramesh Kumar, Joe Yeong Poh Sheng, Ellen Karasik, Barbara A. Foster, Han Yu, Xiang Ling, Wenjie Wu, Fengzhi Li, Zoë Weaver Ohler, Christine Fillmore Brainson, David W. Goodrich, Wanjin Hong, Sayan Chakraborty
An Agrin-Yap/Taz Rigidity Sensing Module Drives Egfr-Addicted Lung Tumorigenesis., Reza Bayat Mokhtari, Divyaleka Sampath, Paige Eversole, Melissa Ong Yu Lin, Dmitriy A. Bosykh, Gandhi T. K. Boopathy, Aravind Sivakumar, Cheng-Chun Wang, Ramesh Kumar, Joe Yeong Poh Sheng, Ellen Karasik, Barbara A. Foster, Han Yu, Xiang Ling, Wenjie Wu, Fengzhi Li, Zoë Weaver Ohler, Christine Fillmore Brainson, David W. Goodrich, Wanjin Hong, Sayan Chakraborty
Markey Cancer Center Faculty Publications
Despite epidermal growth factor receptor (EGFR) is a pivotal oncogene for several cancers, including lung adenocarcinoma (LUAD), how it senses extracellular matrix (ECM) rigidity remain elusive in the context of the increasing role of tissue rigidity on various hallmarks of cancer development. Here it is shown that EGFR dictates tumorigenic agrin expression in lung cancer cell lines, genetically engineered EGFR-driven mouse models, and human specimens. Agrin expression confers substrate stiffness-dependent oncogenic attributes to EGFR-reliant cancer cells. Mechanistically, agrin mechanoactivates EGFR through epidermal growth factor (EGF)-dependent and independent modes, thereby sensitizing its activity toward localized cancer cell-ECM adherence and bulk rigidity …
Temporal Immune Profiling In The Cerebrospinal Fluid And Blood Of Patients With Aneurysmal Subarachnoid Hemorrhage, Thomas A. Ujas, Katie L. Anderson, Jenny Lutshumba, Samantha N. Hart, Jadwiga Turchan-Cholewo, Kevin W. Hatton, Adam D. Bachstetter, Barbara S. Nikolajczyk, Ann M. Stowe
Temporal Immune Profiling In The Cerebrospinal Fluid And Blood Of Patients With Aneurysmal Subarachnoid Hemorrhage, Thomas A. Ujas, Katie L. Anderson, Jenny Lutshumba, Samantha N. Hart, Jadwiga Turchan-Cholewo, Kevin W. Hatton, Adam D. Bachstetter, Barbara S. Nikolajczyk, Ann M. Stowe
Surgery Faculty Publications
Delayed cerebral ischemia (DCI) is a significant complication of aneurysmal subarachnoid hemorrhage (aSAH). This study profiled immune responses after aSAH and evaluated their association with DCI onset. Twelve aSAH patients were enrolled. Leukocyte populations and cytokine levels were analyzed in cerebrospinal fluid (CSF) and peripheral blood (PB) on days 3, 5, 7, 10, and 14 post-aSAH. PB mononuclear cells (PBMCs) were collected, and their cytokine production quantified following stimulation. Mixed-effects models reveal distinct immune cell dynamics in CSF compared with blood. Monocyte/macrophage numbers continue to increase in both CSF and PBMCs for days post-aSAH. CD4+ human leukocyte antigen II+ …
Shared Roles Of Immune And Stromal Cells In The Pathogenesis Of Human Bronchiolitis Obliterans Syndrome, Patrick W. Mellors, Ana N. Lange, Bruno Casino Remondo, Maksim Shestov, Joseph D. Planer, Andrew R. Peterson, Yun Ying, Su Zhou, Jason D. Christie, Joshua M. Diamond, Edward Cantu, Maria C. Basil, Saar Gill
Shared Roles Of Immune And Stromal Cells In The Pathogenesis Of Human Bronchiolitis Obliterans Syndrome, Patrick W. Mellors, Ana N. Lange, Bruno Casino Remondo, Maksim Shestov, Joseph D. Planer, Andrew R. Peterson, Yun Ying, Su Zhou, Jason D. Christie, Joshua M. Diamond, Edward Cantu, Maria C. Basil, Saar Gill
Surgery Faculty Publications
Bronchiolitis obliterans syndrome (BOS) is a progressive, fatal obstructive lung disease that occurs following lung transplant, where it is termed chronic lung allograft dysfunction BOS (CLAD-BOS), or as the primary manifestation of pulmonary chronic graft versus host disease (cGVHD-BOS) following allogeneic hematopoietic stem cell transplant. Disease pathogenesis is poorly understood; however, chronic alloreactivity is common to both conditions, suggesting a shared pathophysiology. We performed single-cell RNA-Seq (scRNA-Seq) on explanted human lungs from 4 patients with CLAD-BOS, 3 patients with cGVHD-BOS, and 3 deceased controls to identify cell types, genes, and pathways enriched in BOS to better understand disease mechanisms. In …
Reproductive Performance And Milk Composition Of Sows Fed Diets Supplemented With An Immunomodulator, Mark J. Estienne, Jung W. Lee, R. Tyler Niblett, Brooke D. Humphrey, H. James Monegue, Merlin D. Lindemann
Reproductive Performance And Milk Composition Of Sows Fed Diets Supplemented With An Immunomodulator, Mark J. Estienne, Jung W. Lee, R. Tyler Niblett, Brooke D. Humphrey, H. James Monegue, Merlin D. Lindemann
Animal and Food Sciences Faculty Publications
A cooperative study involving 189 litters from 114 sows (initial BW of 200.8 ± 37.1 kg) at two experiment stations was conducted to investigate the effects of dietary supplementation with OmniGen-AF (OG) (Phibro Animal Health Co., Teaneck, NJ, USA), a nutritional product formulated to improve immune function of animals, on sow reproductive performance and milk composition. Dietary treatments were (1) corn–soybean meal-based control diets or (2) control diets supplemented with OG at 0.75% (~9 g of OG/100 kg BW/d). Supplementation of diets with OG resulted in lesser (p < 0.05) BW changes of sows during lactation (−12.1 vs. −8.2 kg). Litter sizes for control and OG-fed sows were similar, but sows fed OG-based diets had greater (p < 0.05) litter weight for total born (18.3 vs. 19.3 kg) and weaned (63.2 vs. 67.0 kg) and lactation litter gain (47.8 vs. 50.7 kg). Lactation feed intake for the controls and OG-fed sows (5.32 vs. 5.52 kg/d, respectively) did not differ. Supplementing diets with OG increased lactose content (5.78 vs. 5.84%; p = 0.05) and reduced protein content (4.77 vs. 4.68%; p = 0.04) in sow milk. In conclusion, dietary supplementation with OG at 0.75% reduced weight loss during lactation and improved litter weights with marginal effects on the milk composition of sows.
Glycosylation Of Serine/Threonine-Rich Intrinsically Disordered Regions Of Membrane-Associated Proteins In Streptococci., Mohammad M Rahman, Svetlana Zamakhaeva, Jeffrey S. Rush, Catherine T Chaton, Cameron W Kenner, Yin Mon Hla, Ho-Ching Tiffany Tsui, Vladimir N Uversky, Malcolm E Winkler, Konstantin V Korotkov, Natalia Korotkova
Glycosylation Of Serine/Threonine-Rich Intrinsically Disordered Regions Of Membrane-Associated Proteins In Streptococci., Mohammad M Rahman, Svetlana Zamakhaeva, Jeffrey S. Rush, Catherine T Chaton, Cameron W Kenner, Yin Mon Hla, Ho-Ching Tiffany Tsui, Vladimir N Uversky, Malcolm E Winkler, Konstantin V Korotkov, Natalia Korotkova
Molecular and Cellular Biochemistry Faculty Publications
Proteins harboring intrinsically disordered regions (IDRs) lacking stable secondary or tertiary structures are abundant across the three domains of life. These regions have not been systematically studied in prokaryotes. Here, our genome-wide analysis identifies extracytoplasmic serine/threonine-rich IDRs in several biologically important membrane-associated proteins in streptococci. We demonstrate that these IDRs are glycosylated with glucose by glycosyltransferases GtrB and PgtC2 in Streptococcus pyogenes and Streptococcus pneumoniae, and with N-acetylgalactosamine by a Pgf-dependent mechanism in Streptococcus mutans. The absence of glycosylation leads to a defect in biofilm formation under ethanol-stressed conditions in S. mutans. We link this phenotype to the C-terminal IDR …
Pparα Regulates Er–Lipid Droplet Protein Calsyntenin-3Β To Promote Ketogenesis In Hepatocytes, Lauren F. Uchiyama, Alexander Nguyen, Kevin Qian, Liujuan Cui, Khoi T. Pham, Xu Xiao, Yajing Gao, Yuta Shimanaka, Marcus J. Tol, Laurent Vergnes, Karen Reue, Peter Tontonoz
Pparα Regulates Er–Lipid Droplet Protein Calsyntenin-3Β To Promote Ketogenesis In Hepatocytes, Lauren F. Uchiyama, Alexander Nguyen, Kevin Qian, Liujuan Cui, Khoi T. Pham, Xu Xiao, Yajing Gao, Yuta Shimanaka, Marcus J. Tol, Laurent Vergnes, Karen Reue, Peter Tontonoz
Physiology Faculty Publications
Ketogenesis requires fatty acid flux from intracellular (lipid droplets) and extrahepatic (adipose tissue) lipid stores to hepatocyte mitochondria. However, whether interorganelle contact sites regulate this process is unknown. Recent studies have revealed a role for Calsyntenin-3β (CLSTN3β), an endoplasmic reticulum–lipid droplet contact site protein, in the control of lipid utilization in adipose tissue. Here, we show that Clstn3b expression is induced in the liver by the nuclear receptor PPARα in settings of high lipid utilization, including fasting and ketogenic diet feeding. Hepatocyte-specific loss of CLSTN3β in mice impairs ketogenesis independent of changes in PPARα activation. Conversely, hepatic overexpression of CLSTN3β …
Pyroptosis Of Pulmonary Fibroblasts And Macrophages Through Nlrc4 Inflammasome Leads To Acute Respiratory Failure, Yan Zhang, Guoying Zhang, Brittany Dong, Ankit Pandeya, Jian Cui, Samuel Dos Santos Valenca, Ling Yang, Jiaqian Qi, Zhuodong Chai, Congqing Wu, Daniel Kirchhofer, Toshihiko Shiroishi, Fadi Khasawneh, Min Tao, Feng Shao, Christopher M. Waters, Yinan Wei, Zhenyu Li
Pyroptosis Of Pulmonary Fibroblasts And Macrophages Through Nlrc4 Inflammasome Leads To Acute Respiratory Failure, Yan Zhang, Guoying Zhang, Brittany Dong, Ankit Pandeya, Jian Cui, Samuel Dos Santos Valenca, Ling Yang, Jiaqian Qi, Zhuodong Chai, Congqing Wu, Daniel Kirchhofer, Toshihiko Shiroishi, Fadi Khasawneh, Min Tao, Feng Shao, Christopher M. Waters, Yinan Wei, Zhenyu Li
Chemistry Faculty Publications
The NAIP/NLRC4 inflammasome plays a pivotal role in the defense against bacterial infections, with its in vivo physiological function primarily recognized as driving inflammation in immune cells. Acute lung injury (ALI) is a leading cause of mortality in sepsis. In this study, we identify that the NAIP/NLRC4 inflammasome is highly expressed in both macrophages and pulmonary fibroblasts and that pyroptosis of these cells plays a critical role in lung injury. Mice challenged with gram-negative bacteria or flagellin developed lethal lung injury, characterized by reduced blood oxygen saturation, disrupted lung barrier function, and escalated inflammation. Flagellin-induced lung injury was protected in …
Targeting Mtor In Myeloid Cells Prevents Infection-Associated Inflammation, Yohana C. Toner, Jazz Munitz, Geoffrey Prevot, Judit Morla-Folch, William Wang, Yuri Van Elsas, Bram Priem, Jeroen Deckers, Tom Anbergen, Thijs J. Beldman, Eliane E.S. Brechbühl, Muhammed D. Aksu, Athanasios Ziogas, Sebastian A. Sarlea, Mumin Ozturk, Zhenhua Zhang, Wenchao Li, Yang Li, Alexander Maier, Jessica C. Fernandes, Glenn A.O. Cremers, Bas Van Genabeek, Joost H.C.M. Kreijtz, Esther Lutgens, Niels P. Riksen, Henk M. Janssen, Serge H.M. Söntjens, Freek J.M. Hoeben
Targeting Mtor In Myeloid Cells Prevents Infection-Associated Inflammation, Yohana C. Toner, Jazz Munitz, Geoffrey Prevot, Judit Morla-Folch, William Wang, Yuri Van Elsas, Bram Priem, Jeroen Deckers, Tom Anbergen, Thijs J. Beldman, Eliane E.S. Brechbühl, Muhammed D. Aksu, Athanasios Ziogas, Sebastian A. Sarlea, Mumin Ozturk, Zhenhua Zhang, Wenchao Li, Yang Li, Alexander Maier, Jessica C. Fernandes, Glenn A.O. Cremers, Bas Van Genabeek, Joost H.C.M. Kreijtz, Esther Lutgens, Niels P. Riksen, Henk M. Janssen, Serge H.M. Söntjens, Freek J.M. Hoeben
Physiology Faculty Publications
Infections, cancer, and trauma can cause life-threatening hyperinflammation. In the present study, using single-cell RNA sequencing of circulating immune cells, we found that the mammalian target of rapamycin (mTOR) pathway plays a critical role in myeloid cell regulation in COVID-19 patients. Previously, we developed an mTOR-inhibiting nanobiologic (mTORi-nanobiologic) that efficiently targets myeloid cells and their progenitors in the bone marrow. In vitro, we demonstrated that mTORi-nanobiologics potently inhibit infection-associated inflammation in human primary immune cells. Next, we investigated the in vivo effect of mTORi-nanobiologics in mouse models of hyperinflammation and acute respiratory distress syndrome. Using 18F-FDG uptake and flow …
Grassland For Our World, F Riveros
Grassland For Our World, F Riveros
IGC Proceedings (1977-2023)
The present-day role of grasslands and fodder is reviewed with respect agriculture, animal production and environmental concerns. The world 's grazing lands are a finite resource nnd, overall, are being badly mnnaEed; in most developing countries action is required now, before it is too lnte. They will continue to be a major source of animal feed for the foreseeable future; encroachment from cropping will con
Human Impact On Terrestrial Ecosytems- What We Know And What We Are Doing About It, H A. Mooney
Human Impact On Terrestrial Ecosytems- What We Know And What We Are Doing About It, H A. Mooney
IGC Proceedings (1977-2023)
At present the impact of humankind on the Barth System is substantial mul will become greater as we continue to add over 80 million people to the global population each year. Collectively the human species utilises over a third of the total fresh water that is available, as well as an equivalent amount of tho total terrestrial productivity. Possil energy is being consumed at a prodigious rnte and fuels, among other things, over a half a billion vehicles. To support the large human population the Earth has been greatly reconfigured with much of the land utilised for grazing and agriculture. …
Grasslands For Sustainable Ecosystems, Malcolm Hadley
Grasslands For Sustainable Ecosystems, Malcolm Hadley
IGC Proceedings (1977-2023)
Grasslnnds present many advantages for examining issues related to sustainability. Grasslands include planted pastures as well as a variety of natural rangelands in situations ranging from semi-arid to subhumid. Diversity is also reflected in the spectrum of grassland users and uses, for example, nomadic pastoralism, extensive ranches, intensive pastures, wildlife tourism, game hunting. And in terms of sustainability of resource management, grasslands encompass a wide range of contrasting situations and conflicts in resource use. Heavy grazing pressure associated with increasing human populations in certain tropical savannas, the implications of rural depopulation to traditional pasture management in alpine regions, and the …
Red Clover Hybrid Ryegrass Associations Results Obtained From 1984 To 1987 In Four French Regions, C Pfitzenmeyer, C Longueval
Red Clover Hybrid Ryegrass Associations Results Obtained From 1984 To 1987 In Four French Regions, C Pfitzenmeyer, C Longueval
IGC Proceedings (1977-2023)
In France, red clover is often grown in association with a grass in order, if not to increase the yield of forage, at least to improve its quality by having a larger protein content in the harvested product. Among the grass species associated to red clover, Italian ryegrass, too aggressive a competitor, is replaced more and more by hybrid ryegrass. The aims of the present work were the following
1% to obtain quantitative references on the behaviour o[ hybrid ryegrass/red clover associations in four contrasting regions of France ;
2% to check that the presence of clover, through the transfer …
Potentials Of Summer Fodders Under Intensive Cropping System In India, M S. Tiwana, Thakur Singh
Potentials Of Summer Fodders Under Intensive Cropping System In India, M S. Tiwana, Thakur Singh
IGC Proceedings (1977-2023)
One of the reasons for low milk production in India is the non-availability of good quality fodders in sufficient quantity. Therefore, it is necessary to bridge the gap of this acute shortage of fodder for increasing the milk production. There seems to be no possibility of increasing area under fodders and the only alternative looks to be the ulilization of vacant land (70 days) after harvesting wheat and before the sowing of main summer season crops. However, the growing of these crops may have some effect on the yield of succeeding crops by depleting or replenishing the nutrient status of …
Competitive Effects On Production Of Lolium Perenne L. And Trifolium Alexandrinum L. In Mixture And Mono-Culture, M S. Tiwana, K P. Puri, I S. Thind
Competitive Effects On Production Of Lolium Perenne L. And Trifolium Alexandrinum L. In Mixture And Mono-Culture, M S. Tiwana, K P. Puri, I S. Thind
IGC Proceedings (1977-2023)
Berscem (Trifolium alexandrinum L.) is grown as a fodder crop by every farmer of north India. Though it is a very good multi-cul legume fodder, yet its dry matter percentage is low which indirectly affects the total dry matter production over a period of 6 to 7 months. Presently no suitable multicut grass for the same period is available which may be grown separately or in mixture with berseem to produce high dry matter yield. The first successful planting of ryegrass in research trials was made in 1976 (Tiwana and Puri, 1984) in India. After that, we became interested …
Herbage Yield Of Annual Ryegrass (Lolium Multiflorium Lam.) And Common Vetch (Vicia Sativa L.) At Different Seeding Rates, M A. Jimenez, O L. Gallegos, M.J L. Castrellon
Herbage Yield Of Annual Ryegrass (Lolium Multiflorium Lam.) And Common Vetch (Vicia Sativa L.) At Different Seeding Rates, M A. Jimenez, O L. Gallegos, M.J L. Castrellon
IGC Proceedings (1977-2023)
Most of the dairy farms in the Central Valley of Mexico have alfalfa and corn silage as major forages. Winters are mild, however, yield of alfalfa is reduced and no corn can be grown. Forage crops as oats, annual ryegrass and common vetch have been grown successfully to supply winter forage (Avendano, 1978; Victoria, 1981). Annual rycgrass generally outyields oats, but a high input of nitrogen is required by annual rye grass (Ciane, 1978). The high cost of N fertilizers prevents their use and cheaper N sources should be sought. Legumes as common vetch grown with annual ryegrass can be …
Performance Of White Clover Cultivars In Mixtures With Orchardgrass In Atlantic Canada, Joanna Fraser, H T. Kunelius
Performance Of White Clover Cultivars In Mixtures With Orchardgrass In Atlantic Canada, Joanna Fraser, H T. Kunelius
IGC Proceedings (1977-2023)
The climate in the Atlantic Provinces of Canada is ideally suited to pasture production, with up to seven months of growing season in some areas. Moreover, many of the soils are too shallow to support deep-rooted and highly valued forages such as alfalfa (Medicago sativa L.) and corn (Zea mays L.). However, the main limiting factor to pasture production occurs in spring where there are frequent freeze-thaw cycles, which reduce the dependability of snow cover for insulation, and this results in winter injury (Dzikowski et al., 1984). The interest in white clover (Trifolium repens L.) as a …
Comparison Of Ryegrass-White Clover And Competitive Interactions In New Zealand And Wales, W Harris, I Rhodes
Comparison Of Ryegrass-White Clover And Competitive Interactions In New Zealand And Wales, W Harris, I Rhodes
IGC Proceedings (1977-2023)
New Zealand and Wales have temperate climates suitable for ryegrass (Lolium species) and white clover (Trifolium repens) pasture. However, pasture management in New Zealand and Wales in fundamentally different. New Zealand pastures are grazed all year, whereas in Wales pastures are mostly not grazed in winter. Moreover New Zealand pastures mostly rely on nitrogen fixed by legumes, whereas nitrogen fertiliser is commonly applied to Welsh pastures. To consider the basis of differences of pasture management in New Zealand and Wales, data from field experiments at Aberystwyth, Wales (Lat. 52°25'N) and Palmerston North, New Zealand (Lat. 40°20'S) are …
Forage Contribution Of Overseeded Cool-Season Clovers, G D. Mooso
Forage Contribution Of Overseeded Cool-Season Clovers, G D. Mooso
IGC Proceedings (1977-2023)
Warm-season perennial grasses are the foundation of pasture systems in the southeastern U.S. Though well adapted, these species require significant amounts of nitrogen (N) fertilizers to maintain forage production. Nitrogen fertilizers are widely used to improve the yield and quality of grass pastures because it was less expensive and easier to manage than grass-legume mixtures. Cool-season clovers overseeded into dormant perennial warm-season swards offer a practical method to extend the grazing season and improve forage quality while capitalizing on the ability of inoculated clovers to supply nitrogen to production systems thus decreasing production costs (Burton, 1976 ; Hoveland et al., …
Effect Of Irrigation On Vegetation Succession And Forage Regerneration, Fu Jing-Yan
Effect Of Irrigation On Vegetation Succession And Forage Regerneration, Fu Jing-Yan
IGC Proceedings (1977-2023)
No abstract provided.
Reponse Du Brome Cathartique A L’Irrigation Premiers Resultats, C Longueval
Reponse Du Brome Cathartique A L’Irrigation Premiers Resultats, C Longueval
IGC Proceedings (1977-2023)
L'interet de J'irrigation des graminees prairiales est unc question souvent debattue dans le sud de la France ou la secheresse estivalc ct frequemment automnale limite considerablement la production de fourrage vert durant cette deuxiemc moitie de l'annee. Dans la region toulousaine, les travaux de l'INRA a Toulouse (Marty et al., 1977) ct de la Compagnic d'Amenagemenl des Coteaux de Gascogne ont montre, pour la fetuque et le dactyle notamment, que si !'irrigation pcrrnet de doubler la production estivale et automnale. le niveau attcint sans restriction hydrique reste globalement rr{odcstc puisque inferieur a 5 t/ha M.S. a partir du debut de …
Drought Stress And Alfalfa Production In A Mediterranean Environment, T Kipnis, I Vaisman, I Granoth
Drought Stress And Alfalfa Production In A Mediterranean Environment, T Kipnis, I Vaisman, I Granoth
IGC Proceedings (1977-2023)
Many experimental results have shown a close relationship between total dry matter (DM) yield of alfalfa and annual evapotranspiration (ET). However, this relationship may differ from harvest to harvest (Metochis and Orphanos, 1981), indicating that water use efficiency (WUE) may vary during the growing season, particulary as it is adversely affected by high temperature (Sammis, 1981). Water for irrigating alfalfa is often scarce during the dry Mediterranean summer in Israel. Under such conditions, water is withheld for approximately two months, at a relatively advanced stage of maturity, and the crop is allowed to go to seed, after which irrigation is …
On The Cultivation And Utilization Of Floret Silvergrass (Miscanthus Floridulus) In The Southern Area Of China, Zhu Bangchang
On The Cultivation And Utilization Of Floret Silvergrass (Miscanthus Floridulus) In The Southern Area Of China, Zhu Bangchang
IGC Proceedings (1977-2023)
The plant genus Miscanthus (silvergrass) includes eight species and one variety in China. In the tropical and subtropical area of south China, the silvergrass distributed widely includes the following seven species : Floret silvergrass ( Miscanthus floridulus), Chinese silvergrass ( M. sinensis), Sugary silvergrass ( M. sacchariflorus), Short-hair silvergrass ( M. brevipilus j, Eulalia silver grass ( M. eulalioides), Szechuan silvcrgrass ( M. szechuanensis), Nepal silvergrass ( M. nepalen�� sis). One of them, Floret silvergrass, is the widest in distribution and the highest in economical value, and plays a most important role in …