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Pharmaceutically Engineered Nanoparticles For Enhancing Immune Responses To Hiv-1 Tat And Gag P24 Proteins, Jigna D. Patel Jan 2006

Pharmaceutically Engineered Nanoparticles For Enhancing Immune Responses To Hiv-1 Tat And Gag P24 Proteins, Jigna D. Patel

University of Kentucky Doctoral Dissertations

These studies were aimed at investigating the potential application of nanoparticles engineered from oil-in-water microemulsion precursors for enhancing immune responses to HIV-1 Tat and Gag p24 proteins. Both of the HIV-1 proteins have been reported to be critical in the virus life cycle and are being evaluated in clinical trials as vaccine candidates. Anionic nanoparticles were prepared using emulsifying wax as the oil phase and Brij 78 and sodium dodecyl sulfate as the surfactants. The resulting nanoparticles were coated with Tat and were demonstrated to produce superior immune responses after administration to BALB/c mice compared to Tat adjuvanted with Alum. …

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Variational Methods For Image Deblurring And Discretized Picard's Method, James H. Money Jan 2006

Variational Methods For Image Deblurring And Discretized Picard's Method, James H. Money

University of Kentucky Doctoral Dissertations

In this digital age, it is more important than ever to have good methods for processing images. We focus on the removal of blur from a captured image, which is called the image deblurring problem. In particular, we make no assumptions about the blur itself, which is called a blind deconvolution. We approach the problem by miniming an energy functional that utilizes total variation norm and a fidelity constraint. In particular, we extend the work of Chan and Wong to use a reference image in the computation. Using the shock filter as a reference image, we produce a superior result …

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Structural And Functional Studies Of Synaptic Enzymes, Eun Jeong Lim Jan 2006

Structural And Functional Studies Of Synaptic Enzymes, Eun Jeong Lim

University of Kentucky Doctoral Dissertations

Thimet oligopeptidase (TOP, EC 3.4.24.15) and neurolysin (EC 3.4.24.16) are zincdependent metallopeptidases that metabolize small bioactive peptides. The two enzymes share60 % sequence identity and their crystal structures demonstrate that they adopt nearly identicalfolds. They generally cleave at the same sites, but they recognize different positions on somepeptides, including neurotensin, a 13-residue peptide involved in modulation of dopaminergiccircuits, pain perception, and thermoregulation.On the basis of crystal structures and previous mapping studies, four residues(E469/R470, M490/R491, H495/N496, and R498/T499, TOP residues listed first) in thesubstrate-binding channel appear positioned to account for differences in specificity. TOPmutated to the neurolysin residues at all four …

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Solution And Solid State Interactions Between Ionic Π-Systems, Jing Chen Jan 2006

Solution And Solid State Interactions Between Ionic Π-Systems, Jing Chen

University of Kentucky Doctoral Dissertations

Although attractive interactions between π systems (π-π interaction) have been known for many years, understanding of its origin is still incomplete. Quantitative measuring of π-stacking is challenging due to the weak nature of the π-π interaction. This dissertation aims at elucidating a quantitative conformational analysis by NMR ring current anisotropy of an organic compound capable of intramolecular π-stacking in solution and studying charge effects on the stacking of π-systems. This dissertation offers four contributions to the area. (1) A general approach to four-state, conformational analysis based on the magnetic anisotropy of molecules undergoing fast dynamic exchange is described. (2) Study …

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Group 13 Chelates In Phosphate Dealkylation, Amitabha Mitra Jan 2006

Group 13 Chelates In Phosphate Dealkylation, Amitabha Mitra

University of Kentucky Doctoral Dissertations

A series of mononuclear boron halides of the type LBX2 (LH = N-phenyl-3,5-di-tbutylsalicylaldimine,X = Cl (2), Br (3)) and LBX ( LH2 = N-(2-hydroxyphenyl)-3,5-di-tbutylsalicylaldimine,X = Cl (7), Br (8); LH2 = N-(2-hydroxyethyl)-3,5-di-tbutylsalicylaldimine,X = Cl (9), Br (10); LH2= N-(3-hydroxypropyl)-3,5-di-tbutylsalicylaldimine,X = Cl (11), Br (12)) were synthesized from their borate precursorsLB(OMe)2 (1) (LH = N-phenyl-3,5-di-t-butylsalicylaldimine ) and LB(OMe) (LH2 = N-(2-hydroxyphenyl)-3,5-di-t-butylsalicylaldimine (4), N-(2-hydroxyethyl)-3,5-di-tbutylsalicylaldimine(5), N-(3-hydroxypropyl)-3,5-di-t-butylsalicylaldimine (6)). Theborate precursors, 1, 4 - 6, in turn, were prepared by refluxing the corresponding ligandsLH or LH2 with excess B(OMe)3. The boron halide compounds were air- and moisturesensitiveand compound 7 on hydrolysis gave the oxo-bridged compound …

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Multifunctional Potential Therapeutics Towards Oxidative Stress Mediated Neurodegenerative Disorders And Models Thereof, Gururaj Joshi Jan 2006

Multifunctional Potential Therapeutics Towards Oxidative Stress Mediated Neurodegenerative Disorders And Models Thereof, Gururaj Joshi

University of Kentucky Doctoral Dissertations

The studies described in this dissertation were performed with the goal of understandingthe function of antioxidant compounds delivered in vivo to rodents and the implication of theresults towards oxidative stress (OS)-related neurodegenerative disorders with particularemphasis on Alzheimer's disease (AD). OS has been implicated in AD and is characterized byextensive oxidative damage to protein, lipids and DNA. A major thrust of this dissertation workwas to gain insight into antioxidant properties of compounds used in the following studies andtheir efficacy as potential therapeutics for treatment of OS-related disorders.D609, a glutathione (GSH) mimetic is known to trap OH. Radicals, scavenge H2O2 andreduce the …

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Reconciling Biophysical And Psychosocial Models Of Stress In Relocation Among Older Women, Heidi Harriman Ewen Jan 2006

Reconciling Biophysical And Psychosocial Models Of Stress In Relocation Among Older Women, Heidi Harriman Ewen

University of Kentucky Doctoral Dissertations

The decision to relocate or to age in place can be a difficult one, mitigated by a variety of influencing factors such as finances, physical abilities, as well as social and instrumental support from family and others. This study focuses on the stresses of residential relocation to independent and assisted living facilities among older women living in Lexington, Kentucky. Participation entailed three semi-structured interviews as well as saliva and blood sampling over a period of 6 months, beginning within one month of the move. Measures of cortisol were used as indicators of stress reactivity. Distinct patterns of cortisol response have …

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Synthesis And Evaluation Of Pyridinium Derivatives As Central Nervous System Nicotinic Acetylcholine Receptor Ligands, Joshua Thomas Longen Ayers Jan 2006

Synthesis And Evaluation Of Pyridinium Derivatives As Central Nervous System Nicotinic Acetylcholine Receptor Ligands, Joshua Thomas Longen Ayers

University of Kentucky Doctoral Dissertations

This project utilized synthesis and in vitro assays to generate antagonist SARs at various nAChR subtypes. Alkylation of the pyridino nitrogen of the nicotine molecule afforded subtype specific antagonists at a42* nAChR subtypes and nAChR subtypes that mediate nicotine-evoked dopamine release. Using this data, a series of mono-azaaromatic quaternary salts were produced and evaluated in binding and functional assays for a42* and a7* nAChR subtypes and nAChR subtypes that mediate nicotine-evoked dopamine release. Additionally, bis-azaaromatic quaternary salts were synthesized and evaluated in the same assays. Two potent lead compounds were identified. N-n-dodecylnicotinium iodide (NDDNI) was found to be very potent …

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Cd(Ii)-, Pb(Ii)- And Hg(Ii)-2-Aminoethanethiolates, Mohan Singh Bharara Jan 2006

Cd(Ii)-, Pb(Ii)- And Hg(Ii)-2-Aminoethanethiolates, Mohan Singh Bharara

University of Kentucky Doctoral Dissertations

This theses presents the synthesis and characterization of Cd(II)-, Pb(II)- and Hg(II)-aminoethanethiolates in aqueous media. 2-Aminoethanethiolate, a versatile sulfur andnitrogen (S/N) based ligand was used due to its resemblance to the naturally occurringamino acid, cysteine. The work is presented in four major parts: first, backgroundinformation on the versatile structural chemistry of Cd, Pb and Hg-thiolates with S/Ncontaining ligands; second, synthesis and characterization of Cd(II) with 2-aminoethanethiolates; third, synthesis and characterization and structural chemistry ofPb(II) with 2-aminoethanethiolates; and fourth, synthesis and characterization of Hg(II)-2-aminoethanethiolates in solution- and solid-state with emphasis on the mechanisticpathways for the formation of clusters.The compounds reported here …

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The Genetic Regulation Of The Response Of Hematopoietic Stem/Progenitor Cells To The Cytostatic Agent Hydroxyurea, Jeffrey Lynn Yates Jan 2006

The Genetic Regulation Of The Response Of Hematopoietic Stem/Progenitor Cells To The Cytostatic Agent Hydroxyurea, Jeffrey Lynn Yates

University of Kentucky Doctoral Dissertations

Cellular proliferation is a key characteristic of hematopoietic stem and progenitor cells (HSC/HPCs) that allows for the production of all blood cell lineages during an individuals lifetime. While this feature of stem cells is strictly regulated during steadystate and stress hematopoiesis, it also contributes to the development of myeloproliferative disorders, such as chronic myelogenous leukemia, essential thrombocythemia, and polycythemia vera. It should come as no surprise then, that common treatments for these diseases often target the proliferative nature of the dysfunctional HSC/HPCs. Thus, the identification of molecular determinants of cell cycle regulation associated with these disorders could serve as targets …

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The Development Of Colletotrichum Graminicola Inside Maize Stalk Tissues, Claire Marie-Pierre Venard Jan 2006

The Development Of Colletotrichum Graminicola Inside Maize Stalk Tissues, Claire Marie-Pierre Venard

University of Kentucky Doctoral Dissertations

Colleotrichum graminicola is the causal agent of anthracnose stalk rot, and is one of the most common and aggressive pathogens of maize. The goal of my Ph.D. project was to contribute to a better understanding of the biology of the interaction between C. graminicola and its host. C. graminicola produces two type of asexual spores: one is produced on the surface of infected tissues and is thought to be involved in the spread of the disease in the field. The second type of spore, oval in shape, is produced inside the infected plant tissues, and was believed to be involved …

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Intergenerational Communication About African American Women's Health: The Sharing Of Health Messages Between Diabetic Mothers And Their Non-Diabetic Adult Daughters, Angela F. Cooke-Jackson Jan 2006

Intergenerational Communication About African American Women's Health: The Sharing Of Health Messages Between Diabetic Mothers And Their Non-Diabetic Adult Daughters, Angela F. Cooke-Jackson

University of Kentucky Doctoral Dissertations

The prevalence of type II diabetes is high among African-American women but research that emphasizes black mothers and their adult daughters is rarely studied in social sciences or communication research. Though existing research addresses various domains of the mother-daughter relationship scant information addresses the significance of talk or the transmission of health information between African-American diabetic mothers and their non-diabetic adult daughters. For that reason, this dissertation investigates information sharing among a sample of African-American mothers with type II diabetes and their non-diabetic adult daughters.This study's two primary research objectives were to: 1. describe whether and how African-American type II …

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Soybean Qtl For Yield And Yield Components Associated With Glycine Soja Alleles, Dandan Li Jan 2006

Soybean Qtl For Yield And Yield Components Associated With Glycine Soja Alleles, Dandan Li

University of Kentucky Doctoral Dissertations

USA soybean germplasm has a narrow genetic base that could be augmented by alleles from the wild species Glycine soja which positively influence agronomic traits. The objective of this study was to identify such alleles for yield and yield component QTL (quantitative trait loci). Two populations of 150 BC2F4 lines were generated from a mating between recurrent parent Glycine max 7499 and donor parent Glycine soja PI 245331 with one line in each population tracing back to the same BC2 plant. Population A was used for the QTL identification analysis and population B was used for the QTL verification test. …

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Spectral Reflectance Of Canopies Of Rainfed And Subsurface Irrigated Alfalfa, Dennis Wayne Hancock Jan 2006

Spectral Reflectance Of Canopies Of Rainfed And Subsurface Irrigated Alfalfa, Dennis Wayne Hancock

University of Kentucky Doctoral Dissertations

The site-specific management of alfalfa has not been well-evaluated, despite the economic importance of this crop. The objectives of this work were to i) characterize the effects of soil moisture deficits on alfalfa and alfalfa yield components and ii) evaluate the use of canopy reflectance patterns in measuring treatment-induced differences in alfalfa yield. A randomized complete block design with five replicates of subsurface drip irrigation (SDI) and rainfed treatments of alfalfa was established at the University of Kentucky Animal Research Center in 2003. Potassium, as KCl, was broadcast on split-plots on 1 October 2004 at 0, 112, 336, and 448 …

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Differentiating Acculturation And Ethnic Identity In Predicting African American Psychosocial Functioning, Andrea Michelle Smith Jan 2006

Differentiating Acculturation And Ethnic Identity In Predicting African American Psychosocial Functioning, Andrea Michelle Smith

University of Kentucky Master's Theses

Ethnic identity is a significant psychological variable for the study of African Americans in the United States and often associated with psychological health. However, the nature of this relationship is sometimes unclear. One reason for the confusion may be that ethnic identity is often confounded with acculturation as they are sometimes used interchangeably in research. Because of this confounding problem, it is not clear whether the relationship between ethnic identity and psychological health is really a reflection of ethnic identity or of ethnic identity confounded with acculturation. Thus, the aim of this study was to use factor analysis to separate …

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Destruction Study Of Toxic Chlorinated Organics Using Bimetallic Nanoparticles And Membrane Reactor: Synthesis, Characterization, And Modeling, Yit-Hong Tee Jan 2006

Destruction Study Of Toxic Chlorinated Organics Using Bimetallic Nanoparticles And Membrane Reactor: Synthesis, Characterization, And Modeling, Yit-Hong Tee

University of Kentucky Master's Theses

Zero-valent metals such as bulk iron and zinc are known to dechlorinate toxicorganic compounds. Enhancement in reaction rates has been achieved through bimetallicnanosized particles such as nickel/iron (Ni/Fe) and palladium/iron (Pd/Fe). Batchdegradation of model compounds, trichlroethylene (TCE) and 2,2'-dichlorobiphenyls(DCB), were conducted using bimetallic Ni/Fe and Pd/Fe nanoparticles. Completedegradation of TCE and DCB is achieved at room temperature. Zero-valent iron, as themajor element, undergoes corrosion to provide hydrogen and electrons for the reductivecatalytic hydrodechlorination reaction. The second dopant metals of nickel and palladium(in nanoscale) act as catalyst for hydrogenation through metal hydride formation thatproduces completely dechlorinated final product. Different compositions of …

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Isoprenoid Analogs As Chemical Genetic Tools To Provide Insights Into Farnesyl Transferase Target Selection And Cellular Activity, Jerry Troutman Jan 2006

Isoprenoid Analogs As Chemical Genetic Tools To Provide Insights Into Farnesyl Transferase Target Selection And Cellular Activity, Jerry Troutman

University of Kentucky Doctoral Dissertations

Protein farnesylation is an essential post-translational modification required for the function of numerous cellular proteins including the oncoprotein Ras. The farnesyl transferase (FTase) catalyzed reaction is unique because farnesyl diphosphate (FPP), the farnesyl group donor for the reaction, forms a significant portion of a target protein binding site. The major goal of this research was to exploit this unique property of the FTase reaction and determine if changing the structure of the farnesyl donor group would affect FTase protein targeting. A small library of structural analogues of FPP was synthesized. Michelis-Menten steady-state kinetic analyses and competition reactions were used to …

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Investigations Into The Cognitive Abilities Of Alternate Learning Classifier System Architectures, David Alexander Gaines Jan 2006

Investigations Into The Cognitive Abilities Of Alternate Learning Classifier System Architectures, David Alexander Gaines

University of Kentucky Doctoral Dissertations

The Learning Classifier System (LCS) and its descendant, XCS, are promising paradigms for machine learning design and implementation. Whereas LCS allows classifier payoff predictions to guide system performance, XCS focuses on payoff-prediction accuracy instead, allowing it to evolve "optimal" classifier sets in particular applications requiring rational thought. This research examines LCS and XCS performance in artificial situations with broad social/commercial parallels, created using the non-Markov Iterated Prisoner's Dilemma (IPD) game-playing scenario, where the setting is sometimes asymmetric and where irrationality sometimes pays. This research systematically perturbs a "conventional" IPD-playing LCS-based agent until it results in a full-fledged XCS-based agent, contrasting …

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Cloning And Expression Of Key Endocrine Genes In A Study On Estrogen Stimulated Sexual Size Dimorphism (Ssd) In Yellow Perch, Scott George Lynn Jan 2006

Cloning And Expression Of Key Endocrine Genes In A Study On Estrogen Stimulated Sexual Size Dimorphism (Ssd) In Yellow Perch, Scott George Lynn

University of Kentucky Doctoral Dissertations

Yellow perch (Perca flavescens) exhibit an estrogen stimulated sexual sizedimorphism (SSD) wherein females grow faster and larger than males. In an effort togain better understanding of this phenomenon, several genes associated with sexualdevelopment, reproduction and growth were cloned, including prolactin (PRL),somatolactin (SL), insulin-like growth factor-I (IGF-Ib), the estrogen receptors (ER?? andER??a) and ovarian aromatase (CYP19A1). Real-time quantitative PCR (qPCR) assaysfor all the genes listed above, plus growth hormone (GH), were developed to measuremRNA levels in pituitary, liver and ovary.Adult fish were collected from Lake Erie in the spring (May) and autumn(October) over two years and tissue mRNA levels, body weight, …

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Oxidative Stress And Redox Proteomics Studies In Models Of Neurodegenerative Disorders: I. The Canine Model Of Human Aging; Ii. Insights Into Successful Aging; And Iii. Traumatic Brain Injury, Wycliffe Omondi Opii Jan 2006

Oxidative Stress And Redox Proteomics Studies In Models Of Neurodegenerative Disorders: I. The Canine Model Of Human Aging; Ii. Insights Into Successful Aging; And Iii. Traumatic Brain Injury, Wycliffe Omondi Opii

University of Kentucky Doctoral Dissertations

The studies presented in this dissertation were conducted with the objective ofgaining greater understanding into the mechanisms of successful aging, the role ofmitochondria dysfunction in traumatic brain injury, and also on the mechanisms ofimproved learning and cognitive function in the aging.Aging is usually characterized by impairments in physiological functionsincreasing its susceptibility to dementia and neurodegenerative disorders. In thisdissertation, the mechanisms of dementia-free aging were investigated. The use of anantioxidant fortified diet and a program of behavioral enrichment in the canine model ofhuman aging was shown to result in a significant decrease in the levels of oxidativestress. A proteomic analysis of …

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Increased Oxidative Damage To Dna And The Effects On Mitochondrial Protein In Alzheimer's Disease, Jianquan Wang Jan 2006

Increased Oxidative Damage To Dna And The Effects On Mitochondrial Protein In Alzheimer's Disease, Jianquan Wang

University of Kentucky Doctoral Dissertations

Alzheimer's disease (AD) is a progressive, irreversible, neurodegenerative disease. The key to understanding AD is to elucidate the pathogenesis of neuron degeneration in specific brain regions.We hypothesize that there is increased DNA oxidation in AD brain compared to age-matched control subjects, especially in mitochondrial DNA (mtDNA), and that the changes in DNA bases will affect protein expression in mitochondria and contribute to neurodegeneration in AD. To test this hypothesis:1) We quantified multiple oxidized bases in nuclear DNA (nDNA) and mtDNA of frontal, parietal, and temporal lobes and cerebellum from late-stage AD (LAD), mild cognitive impairment (MCI), and age-matched control subjects …

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Selective Growth Of Carbon Nanotubes And Oxide Nanowires: Applications In Shadow Lithography And Fabrication Of Aligned Carbon Nanotube Membranes, Nitin Chopra Jan 2006

Selective Growth Of Carbon Nanotubes And Oxide Nanowires: Applications In Shadow Lithography And Fabrication Of Aligned Carbon Nanotube Membranes, Nitin Chopra

University of Kentucky Doctoral Dissertations

A promising approach investigated here is to utilize thin film multilayer structures where the thickness of a catalyst layer at an exposed edge of photolithographically defined pattern determines the diameter of the nanotubes/nanowires grown from it. This can in turn be incorporated into photolithographically defined post structures resulting in an array of suspended nanowires for line-of-site shadow lithography. Success of the diameter control approach has been shown by selectively growing carbon nanotubes (CNTs) from narrow lines (12-60 nm) of SiO2, Fe, Ni, Co on micron-scale patterned substrates in a ferrocene or nonferrocene catalyzed CVD process. In addition, the …

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Hepatic Cytochrome P450 Reductase-Null Mice As An Animal Model To Study Electron Transfer Pathways In Cholesterol Synthesis And Cyp2e1-Mediated Drug Metabolism, Li Li Jan 2006

Hepatic Cytochrome P450 Reductase-Null Mice As An Animal Model To Study Electron Transfer Pathways In Cholesterol Synthesis And Cyp2e1-Mediated Drug Metabolism, Li Li

University of Kentucky Doctoral Dissertations

NADPH-cytochrome P450 reductase (CPR) is a flavoprotein containing both FAD and FMN and functions as the electron donor protein for several oxygenase enzymes found on the endoplasmic reticulum of eukaryotic cells, including cytochrome P450s involved in drug metabolism and cholesterol biosynthesis. As many as three enzymes in the cholesterol biosynthetic pathway have been demonstrated, or proposed, to use CPR as a redox partner: squalene monooxygenase, which converts squalene to 2,3-oxidosqualene; lanosterol demethylase, a cytochrome P450 (CYP51); and 7-dehydrocholesterol reductase, the final step in cholesterol synthesis. In yeast CPR can be replaced by the NADH-cytochrome b5 pathway, but this has not …

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Asymptotic Properties Of Partial Areas Under The Receiver Operating Characteristic Curve With Applications In Microarray Experiments, Hua Liu Jan 2006

Asymptotic Properties Of Partial Areas Under The Receiver Operating Characteristic Curve With Applications In Microarray Experiments, Hua Liu

University of Kentucky Doctoral Dissertations

Receiver operating characteristic (ROC) curves are widely used in medical decision making. It was recognized in the last decade that only a specific region of the ROC curve is of clinical interest, which can be summarized by the partial area under the ROC curve (partial AUC). Early statistical methods for evaluating partial AUC assume that the data are from a specified underlying distribution. Nonparametric estimators of the partial AUC emerged recently, but there are theoretical issues to be addressed. In this dissertation, we propose two new nonparametric statistics, partially integrated ROC and partially integrated weighted ROC, for estimating partial AUC. …

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Identification Of Cis-Acting Elements Controlling Gene Expression In S. Neurona, Rajshekhar Y. Gaji Jan 2006

Identification Of Cis-Acting Elements Controlling Gene Expression In S. Neurona, Rajshekhar Y. Gaji

University of Kentucky Doctoral Dissertations

Sarcocystis neurona is an apicomplexan parasite that is a major cause of equine protozoal myeloencephalitis (EPM). During intracellular development of S. neurona, many genes are temporally regulated. To better understand gene regulation, it is important to identify and characterize regulatory elements controlling gene expression in S. neurona. To perform this study, it was essential to establish transfection system for this parasite. Hence, the 5 flanking region of the SnSAG1 gene was isolated from a genomic library and used to construct expression plasmids. In transient assays, the reporter molecules -galactosidase (-gal) and yellow fluorescent protein (YFP) were expressed by electroporated S. …

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Sal-Site: Integrating New And Existing Ambystomatid Salamander Research And Informational Resources, Jeramiah J. Smith, Srikrishna Putta, John A. Walker, D. Kevin Kump, Amy K. Samuels, James R. Monaghan, David W. Weisrock, Chuck Staben, S. Randal Voss Dec 2005

Sal-Site: Integrating New And Existing Ambystomatid Salamander Research And Informational Resources, Jeramiah J. Smith, Srikrishna Putta, John A. Walker, D. Kevin Kump, Amy K. Samuels, James R. Monaghan, David W. Weisrock, Chuck Staben, S. Randal Voss

Biology Faculty Publications

Salamanders of the genus Ambystoma are a unique model organism system because they enable natural history and biomedical research in the laboratory or field. We developed Sal-Site to integrate new and existing ambystomatid salamander research resources in support of this model system. Sal-Site hosts six important resources: 1) Salamander Genome Project: an information-based web-site describing progress in genome resource development, 2) Ambystoma EST Database: a database of manually edited and analyzed contigs assembled from ESTs that were collected from A. tigrinum tigrinum and A. mexicanum, 3) Ambystoma Gene Collection: a database containing full-length protein-coding sequences, 4) Ambystoma Map and Marker …

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Seventeen Amino Acid Peptide (Peptide P) For Treating Ischemia And Reperfusion Injury, Peter R. Oeltgen, Mark S. Kindy Nov 2005

Seventeen Amino Acid Peptide (Peptide P) For Treating Ischemia And Reperfusion Injury, Peter R. Oeltgen, Mark S. Kindy

Molecular and Cellular Biochemistry Faculty Patents

Peptide P, having the amino acid sequence Tyr-D-Ala-Phe-Ala-Asp-Val-Ala-Ser-Thr-Ile-Gly-Asp-Phe-His-Ser-Ile-NH2-SEQ ID NO:1, is useful to treat ischemia.

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Pumping Or Mixing System Using A Levitating Magnetic Element, Aexandre N. Terentiev Nov 2005

Pumping Or Mixing System Using A Levitating Magnetic Element, Aexandre N. Terentiev

Physics and Astronomy Faculty Patents

A system capable of pumping or mixing fluids using a rotating magnetic element or bearing levitated by a cold superconducting element is disclosed.

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Review: The Discipline Of Law Schools: The Making Of Modern Lawyers (Philip C. Kissam, Carolina Academic Press, 2003), And The Shame Of American Legal Education (Alan Watson, Ph-Dosije, 2004), James M. Donovan Nov 2005

Review: The Discipline Of Law Schools: The Making Of Modern Lawyers (Philip C. Kissam, Carolina Academic Press, 2003), And The Shame Of American Legal Education (Alan Watson, Ph-Dosije, 2004), James M. Donovan

Law Faculty Scholarly Articles

No abstract provided.

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Rate Response Assessment From Various Granular Vrt Applicators, John P. Fulton, Scott A. Shearer, Stephen F. Higgins, Matthew J. Darr, Timothy S. Stombaugh Nov 2005

Rate Response Assessment From Various Granular Vrt Applicators, John P. Fulton, Scott A. Shearer, Stephen F. Higgins, Matthew J. Darr, Timothy S. Stombaugh

Biosystems and Agricultural Engineering Faculty Publications

Variable-rate technology (VRT) adds complexity to application equipment, thereby confounding the assessment of applicator performance. The intent of this investigation was to assess the rate response of various VRT granular applicators: two spinner spreaders (A and B), and two pneumatic applicators (C and D). Variable-rate (VR) tests were conducted to quantify the rate response characteristics (delay and transition times) for the applicators. A sigmoidal function was used to model the rate response for five of the six tests. Applicator A exhibited a linear response during decreasing rate changes. Results indicated that only applicator B demonstrated consistent delay and transition times, …

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