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Objective And Subjective Residential Context And Urban Children’S Weight Status And Physical And Sedentary Activities, Rachel Tolbert Kimbro, Jeanne Brooks-Gunn, Sara Mclanahan

University of Kentucky Center for Poverty Research Discussion Paper Series

This paper fills this gap by addressing two research questions: first, we ask, are the activity patterns (outdoor play and television watching) of five-year-old children living in large cities associated with children’s weight status? Second, we ask, is residential context, and neighborhood safety in particular, associated with children’s activity patterns? Consistent with past research, we find that outdoor play is negatively associated with weight status, while television watching is positively associated with weight status. We also find, unexpectedly, that the poorest children are playing outdoors the most and watching the most television. Finally, we find that three measures of residential …

Race Disparities In Birth Outcomes In The U.S. South And The Rest Of The Nation, Lenna Nepomnyaschy

University of Kentucky Center for Poverty Research Discussion Paper Series

There are well-documented and as yet unexplained disparities in birth outcomes by race in the United States, even after controlling for socioeconomic status. This paper examines the sources of disparities in low birth weight between blacks and whites in the U.S., by focusing on differences in disparities between two very distinct geographic areas, the Deep South and the rest of the country. Two findings from prior research drive the analyses: First, health overall is worse in the Deep South states; Second, race disparities are smaller in the Deep South than in the rest of the nation. A number of potential …

Use Of Co2 Concentration Difference Or Co2 Balance To Assess Ventilation Rate Of Broiler Houses, Hongwei Xin, Hong Li, Robert T. Burns, Richard S. Gates, Douglas G. Overhults, John W. Earnest

Biosystems and Agricultural Engineering Faculty Publications

Ventilation rate (VR) is one of the two key elements for quantifying aerial emissions from animal production facilities. Direct, continuous measurement of building VR can be challenging and impractical under certain circumstances,e.g., naturally ventilated animal housing or a large number of ventilation fans in the building. This study examined the suitability of estimating VR of broiler houses with built‐up litter (mixture of manure and bedding), when supplemental heating was not in use, through either carbon dioxide (CO₂) balance or the relationship of VR to CO₂ concentration difference between exhaust and inlet air. The reference VR was based …

Estimating Water Application Efficiency For Drip Irrigation Emitter Patterns On Banana, Alisson Jadavi Pereira Da Silva, Eugênio Ferreira Coelho, Jarbas Honorio De Miranda, Stephen Ray Workman

Biosystems and Agricultural Engineering Faculty Publications

The objective of this work was to evaluate root and water distribution in irrigated banana (Musa sp.), in order to determine the water application efficiency for different drip irrigation emitter patterns. Three drip emitter patterns were studied: two 4-L h^-1 emitters per plant (T1), four 4-L h^-1 emitters per plant (T2), and five 4-L h^-1 emitters per plant (T3). The emitters were placed in a lateral line. In the treatment T3, the emitters formed a continuous strip. The cultivated area used was planted with banana cultivar BRS Tropical, with a 3-m spacing between rows and a …

Violence And Women's Mental Health: The Pain Unequalled, Part One, Carol E. Jordan

Office for Policy Studies on Violence Against Women Publications

No abstract provided.

Georges-Louis Leclerc, Compte De Buffon (1701-1788): The French Rival Of Linnaeus, Charles T. Ambrose

Microbiology, Immunology, and Molecular Genetics Faculty Publications

No abstract provided.

A Place At The Blackboard: Including Lesbian, Gay, Bisexual, Transgender, Intersex, & Queer/Questioning Issues In The Education Process, Todd A. Savage, Debra A. Harley

Early Childhood, Special Education, and Counselor Education Faculty Publications

We know from history that lesbian, gay, bisexual, and transgender people have always existed in society (Campos, 2003; Sullivan, 2003). Lesbian, gay, bisexual, transgender, intersexed, and queer/questioning (LGBTIQ) individuals, collectively known as sexual minorities, represent approximately 10% of the population. As many as nine students in every classroom of 30 are in some measure affected by sexual minority issues (e.g., having a gay or lesbian relative or being gay oneself) (AFSC Gay/Lesbian Youth Program, 1991). “Yet even with this substantial number, the code of silence in our nation’s school systems concerning homosexuality remains” (Fontaine, 1997, pp. 101-102).

Vegf-A As An Inhibitor Of Angiogenesis And Methods Of Using Same, Jayakrishna Ambati

Ophthalmology and Visual Science Faculty Patents

The invention relates to methods and compositions for the treatment or prevention of ocular angiogenesis and neovascularization associated with neovascular disease. Administration of vascular endothelial growth factor (VEGF)-A into the eye when macrophage infiltration is reduced inhibits ocular angiogenesis.

T10b9 Monoclonal Antibody: A Short-Acting Nonstimulating Monoclonal Antibody That Spares Γδ T-Cells And Treats And Prevents Cellular Rejection, Thomas H. Waid, John S. Thompson, Maria Siemionow, Stephen A. Brown

Internal Medicine Faculty Publications

T10B9.1A-31/MEDI-500 is a nonmitogenic immunoglobulin M kappa murine monoclonal antibody (mAb) directed against the alpha-beta (αβ) heterodimer of the T-lymphocyte receptor complex. The hybridoma was first produced by fusing spleen cells from BALB/C mice immunized with human peripheral blood T-lymphocytes with SP2/O-Ag14 mutant myeloma cells. The mAb is produced and purified using multistep ion exchange and molecular sieve chromatography protocols. T10B9 has been used successfully to treat acute cellular rejection in renal transplantation and as an immunosuppression induction agent in heart and simultaneous kidney-pancreas transplantation. Because T10B9 is nonmitogenic and causes minimal cytokine release, both treatment of rejection and induction …

Conservation Of The Glucan Phosphatase Laforin Is Linked To Rates Of Molecular Evolution And The Glucan Metabolism Of The Organism, Matthew S. Gentry, Rachel M. Pace

Molecular and Cellular Biochemistry Faculty Publications

BACKGROUND: Lafora disease (LD) is a fatal autosomal recessive neurodegenerative disease. A hallmark of LD is cytoplasmic accumulation of insoluble glucans, called Lafora bodies (LBs). Mutations in the gene encoding the phosphatase laforin account for approximately 50% of LD cases, and this gene is conserved in all vertebrates. We recently demonstrated that laforin is the founding member of a unique class of phosphatases that dephosphorylate glucans.

RESULTS: Herein, we identify laforin orthologs in a protist and two invertebrate genomes, and report that laforin is absent in the vast majority of protozoan genomes and it is lacking in all other invertebrate …

Hibernation-Like State Induced By An Opioid Peptide Protects Against Experimental Stroke, Cesar V. Borlongan, Teruo Hayashi, Peter R. Oeltgen, Tsung-Ping Su, Yun Wang

Pathology and Laboratory Medicine Faculty Publications

BACKGROUND: Delta opioid peptide [D-ala2,D-leU5]enkephalin (DADLE) induces hibernation in summer ground squirrels, and enhances preservation and survival of isolated or transplanted lungs and hearts. In the present study, we investigated the protective effect of DADLE in the central nervous system.

RESULTS: Adult Sprague-Dawley rats were pretreated with DADLE (4 mg/kg every 2 h x 4 injections, i.p.) or saline prior to unilateral occlusion of the middle cerebral artery (MCA). Daily behavioral tests revealed that ischemic animals treated with DADLE did not show any significant behavioral dysfunctions compared with saline-treated ischemic animals. Opioid antagonists only transiently inhibited the protective effect of …

Reactive Oxygen Species Mediate Tnfr1 Increase After Trpv1 Activation In Mouse Drg Neurons, Fei Ma, Liping Zhang, Karin N. Westlund

Physiology Faculty Publications

Background: Transient receptor potential vanilloid subtype 1 (TRPV1) is activated by low pH/protons and is well known to be involved in hyperalgesia during inflammation. Tumor necrosis factor α (TNF-α), a proinflammatory cytokine, is involved in nociceptive responses causing hyperalgesia through TNF receptor type 1 (TNFR1) activation. Reactive oxygen species (ROS) production is also prominently increased in inflamed tissue. The present study investigated TNFR1 receptors in primary cultured mouse dorsal root ganglion (DRG) neurons after TRPV1 activation and the involvement of ROS. C57BL/6 mice, both TRPV1 knockout and wild type, were used for immunofluorescent and live cell imaging. The L4 and …

Methods To Identify Plant Metabolites, Deane L. Falcone, John M. Littleton

Plant and Soil Sciences Faculty Patents

This invention provides materials and methods to manipulate the plant genome at the level of single plant cells in culture resulting in the ability to assign metabolic functionality to plant genes involved in the production of biologically active molecules and to create a means of product discovery based on the biosynthetic capacity of plants. The materials to create an activation mutagenesis include incorporation of enhancer sequences from a plant viral promoter at random places in the plant genome via Agrobacterium mediated DNA transfer (T-DNA). The usefulness is that genes in the immediate vicinity of the incorporation were activated which allows …

Phylogenetic Analyses Reveal Monophyletic Origin Of The Ergot Alkaloid Gene Dmaw In Fungi, Miao Liu, Daniel G. Panaccione, Christopher L. Schardl

Plant Pathology Faculty Publications

Ergot alkaloids are indole-derived mycotoxins that are important in agriculture and medicine. Ergot alkaloids are produced by a few representatives of two distantly related fungal lineages, the Clavicipitaceae and the Trichocomaceae. Comparison of the ergot alkaloid gene clusters from these two lineages revealed differences in the relative positions and orientations of several genes. The question arose: is ergot alkaloid biosynthetic capability from a common origin? We used a molecular phylogenetic approach to gain insights into the evolution of ergot alkaloid biosynthesis. The 4-γ,γ-dimethylallyltryptophan synthase gene, dmaW, encodes the first step in the pathway. Amino acid sequences deduced …

A Gene Expression Predictor Of Response To Egfr-Targeted Therapy Stratifies Progression-Free Survival To Cetuximab In Kras Wild-Type Metastatic Colorectal Cancer, Justin M. Balko, Esther P. Black

Pharmaceutical Sciences Faculty Publications

BACKGROUND: The anti-EGFR monoclonal antibody cetuximab is used in metastatic colorectal cancer (CRC), and predicting responsive patients garners great interest, due to the high cost of therapy. Mutations in the KRAS gene occur in ~40% of CRC and are a negative predictor of response to cetuximab. However, many KRAS-wildtype patients do not benefit from cetuximab. We previously published a gene expression predictor of sensitivity to erlotinib, an EGFR inhibitor. The purpose of this study was to determine if this predictor could identify KRAS-wildtype CRC patients who will benefit from cetuximab therapy.

METHODS: Microarray data from 80 metastatic CRC patients subsequently …

Biochemical Response Of Landfill With Manufactured Aggregates As A Daily Cover, Zalleris Escobar, Yahaira Lugo, Sangchul Hwang

World of Coal Ash Proceedings

No abstract provided.

Hydraulic And Transport Properties Of Ash Dumps, Adolf October, Jacobus M. Nel, Kelley Reynolds, Candice Lasher

World of Coal Ash Proceedings

No abstract provided.

Environmental And Health Aspects Of Ashes Produced At Co-Combustion Of Biomass, Henk Te Winkel

World of Coal Ash Proceedings

No abstract provided.

Variations In Element Mobility From Fly Ashes Stored In Different Environments, Colin R. Ward, David French, Ken Riley, Zhongsheng Li

World of Coal Ash Proceedings

No abstract provided.

Comparison Of Waste From Pf Utilities And Transitional Technologies Using Australian Coal, David French, Ken Riley, Colin R. Ward, Leanne Stephenson

World of Coal Ash Proceedings

No abstract provided.

Evaluating The Interaction Of Coal Ash Leachates With Rock Materials For Mine Backfill Studies, Colin R. Ward, David French, Leanne Stephenson, Ken Riley

World of Coal Ash Proceedings

No abstract provided.

Coal Combustion By-Product Tools And Mine Pools: Environmental And Geotechnical Engineering Comments From Maryland, Paul A. Petzrick

World of Coal Ash Proceedings

No abstract provided.

Ash Microbiology: A Molecular Study, Kelley A. Reynolds, A. Karen, J. Surridge

World of Coal Ash Proceedings

No abstract provided.

Influence Of Industrial Solid Wastes On Soil-Plant Interactions In Rice Under Acid Lateritic Soil, S. Karmakar, B. N. Mittra, B. C. Ghosh

World of Coal Ash Proceedings

No abstract provided.

Preliminary Microbial Studies On The Impact Of Plants And South African Fly Ash On Amelioration Of Crude Oil Polluted Acid Soils, Akj Surridge, A Van Der Merwe, R Kruger

World of Coal Ash Proceedings

No abstract provided.

Predicting The Efficacy Of Fly Ash As A Soil Ameliorant, Richard A. Kruger, A Karen, J Surridge

World of Coal Ash Proceedings

No abstract provided.

Potential Use Of Surfactant-Modified Zeolite For Attenuation Of Trace Elements In Fly Ash Leachate, Ghanashyam Neupane, Rona J. Donahoe

World of Coal Ash Proceedings

No abstract provided.

Utility Of Phylloplanins As Antibiotics, Selective Fungicides And For Enhancing Microbial Resistance In Crop Plants, George J. Wagner, Ryan W. Shepard

Plant and Soil Sciences Faculty Patents

The invention is directed to methods and compositions that inhibit pathogen proliferation. More particularly, these methods and compositions involve the use of phylloplane proteins as antibiotics against human and animal pathogens.

Local Head Loss Of Non-Coaxial Emitters Inserted In Polyethylene Pipe, Osvaldo Rettore Neto, Jarbas Honorio De Miranda, José Antonio Frizzone, Stephen R. Workman

Biosystems and Agricultural Engineering Faculty Publications

The design of a lateral line for drip irrigation requires accurate evaluation of head losses in not only the pipe but in the emitters as well. A procedure was developed to determine localized head losses within the emitters by the formulation of a mathematical model that accounts for the obstruction caused by the insertion point. These localized losses can be significant when compared with the total head losses within the system due to the large number of emitters typically installed along the lateral line. An experiment was carried out by altering flow characteristics to create Reynolds numbers (R) from 7,480 …

Human Cerebral Neuropathology Of Type 2 Diabetes Mellitus, Peter T. Nelson, Charles D. Smith, Erin L. Abner, Frederick A. Schmitt, Stephen W. Scheff, Gregory J. Davis, Jeffrey N. Keller, Gregory A. Jicha, Daron Davis, Wang-Xia Wang, Adria Hartman, Douglas G. Katz, William R. Markesbery

Pathology and Laboratory Medicine Faculty Publications

The cerebral neuropathology of Type 2 diabetes (CNDM2) has not been positively defined. This review includes a description of CNDM2 research from before the ‘Pubmed Era’. Recent neuroimaging studies have focused on cerebrovascular and white matter pathology. These and prior studies about cerebrovascular histopathology in diabetes are reviewed. Evidence is also described for and against the link between CNDM2 and Alzheimer's disease pathogenesis. To study this matter directly, we evaluated data from University of Kentucky Alzheimer's Disease Center (UK ADC) patients recruited while non-demented and followed longitudinally. Of patients who had come to autopsy (N = 234), 139 met …