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Essays On Fresh Vegetable Production And Marketing Practices, Michael Vassalos Jan 2013

Essays On Fresh Vegetable Production And Marketing Practices, Michael Vassalos

Theses and Dissertations--Agricultural Economics

Commercial fresh vegetable production is one of the most rewarding and risky farming activities. The price and yield variations throughout the production year, the special characteristics of fresh vegetable produce (i.e. perishability), and the changing consumer demands are some of the factors contributing to the increased uncertainty faced by vegetable producers. This dissertation combined mathematical programming and econometric techniques to: 1) investigate the optimal production and marketing practices under different price distribution information scenarios, risk aversion levels and marketing outlets and 2) examine growers’ preferences as well the effect of risk aversion levels and growers’ risk perception on the choice …


A New Way Of Living: Bioeconomic Models In Post-Apocalyptic Dystopias, Margaret A. Wells Jan 2013

A New Way Of Living: Bioeconomic Models In Post-Apocalyptic Dystopias, Margaret A. Wells

Theses and Dissertations--English

The objective of this thesis is to explore the relationship between moralities and bioeconomies in post-apocalyptic dystopias from the Victorian era to contemporary Young Adult Fiction. In defining the terms bioeconomy and biopolitics, this works examines the ways in which literature uses food and energy systems to explore morality and immorality in social orders and systems, including capitalism and our modern techno-industrial landscapes. This work examines science fiction portrayals of apocalypses and dystopias, including After London: Or, Wild England and The Hunger Games, as well as their medieval and contextual influences. These works are analyzed in light of genre …


Randomness, Uncertainty, And Economic Behavior: The Life Of Money In Eighteenth-Century Fiction, Devjani Roy Jan 2013

Randomness, Uncertainty, And Economic Behavior: The Life Of Money In Eighteenth-Century Fiction, Devjani Roy

Theses and Dissertations--English

My dissertation argues that fiction produced in England during the frequent financial crises and political volatility experienced between 1770 and 1820 both reflected and shaped the cultural anxiety occasioned by a seemingly random and increasingly uncertain world. The project begins within the historical framework of the multiple financial crises that occurred in the late eighteenth century: seven crises took place between 1760 and 1797 alone, appearing seemingly out of nowhere and creating a climate of financial meltdown. But how did the awareness of economic turbulence filter into the creative consciousness? Through an interdisciplinary focus on cultural studies and behavioral economics, …


Counting On The Environment: Measuring And Marketing Ecosystem Services In Oregon, Eric Nost Jan 2013

Counting On The Environment: Measuring And Marketing Ecosystem Services In Oregon, Eric Nost

Theses and Dissertations--Geography

New markets for the conservation of so-called ecosystem services, like the ability of a wetland to mitigate floods, are emerging worldwide. According to environmental economists, these markets require some metric - ecological or otherwise - that names the relevant characteristics of the service to be traded as a commodity. But while this is often assumed to be a simple task of science, I argue that the environmental regulators, eco-entrepreneurs, and conservationists who actually design and implement metrics are not so easily brought into agreement. In “rolling-out” revamped metrics and protocols, regulators and their conservationist allies in one market in Oregon …


The Effect Of Augmented Reality Treatment On Learning, Cognitive Load, And Spatial Visualization Abilities, Nedim Slijepcevic Jan 2013

The Effect Of Augmented Reality Treatment On Learning, Cognitive Load, And Spatial Visualization Abilities, Nedim Slijepcevic

Theses and Dissertations--Curriculum and Instruction

This study investigated the effects of Augmented Reality (AR) on learning, cognitive load and spatial abilities. More specifically, it measured learning gains, perceived cognitive load, and the role spatial abilities play with students engaged in an astronomy lesson about lunar phases. Research participants were 182 students from a public university in southeastern United States, and were recruited from psychology research pool. Participants were randomly assigned to two groups: (a) Augmented Reality and Text Astronomy Treatment (ARTAT); and (b) Images and Text Astronomy Treatment (ITAT). Upon entering the experimental classroom, participants were given (a) Paper Folding Test to measure their spatial …


Examining The Influence Of Parents, Teachers, And Neighborhood Safety On African American Adolescents’ Motivation And Achievement, Clarissa R. Roan-Belle Jan 2013

Examining The Influence Of Parents, Teachers, And Neighborhood Safety On African American Adolescents’ Motivation And Achievement, Clarissa R. Roan-Belle

Theses and Dissertations--Educational, School, and Counseling Psychology

Guided by the theoretical frameworks of Baumrind’s parenting style theory, interpersonal expectations, Self Determination Theory, and self-efficacy, this study examines factors that influence African American students’ GPA and motivation, specifically associations between parents’ and teachers’ control, warmth, and educational expectations and African American adolescents’ GPA, self-efficacy, and intrinsic motivation were examined. The moderating effects of neighborhood safety on the aforementioned associations were also assessed. Using data from the Educational Longitudinal Study of 2002, this study found that parents’ warmth and expectations were positive predictors of all educational variables, while parents control was a negative predictor of GPA and intrinsic motivation. …


Support Services And Programmatic Interventions Four-Year Institutions Have In Place To Assist And Graduate Students With Low Academic Credentials: A Mixed Methods Study, Nada El Majzoub Jan 2013

Support Services And Programmatic Interventions Four-Year Institutions Have In Place To Assist And Graduate Students With Low Academic Credentials: A Mixed Methods Study, Nada El Majzoub

Theses and Dissertations--Educational Leadership Studies

This mixed methods study investigates the influence of student characteristics and institutional support services and interventions on graduation rates. Regression analysis was conducted using a dataset constructed from multiple publically available resources to estimate graduation rates. Regression results showed High School Grade Point Average to be the highest estimator of graduation rates, among other student and institutional characteristics. The results confirmed existing findings on the influence of student pre-college and demographic characteristics on graduation rates for students with academic needs. Content analysis of survey data from office of support service personnel at public four-year institutions shows institutions implement a wide …


Behavioral Intentions And Nonmedical Anabolic Steroid Use Among Non Intercollegiate Athlete Males Ages 18-30, Vitesh Enaker Jan 2013

Behavioral Intentions And Nonmedical Anabolic Steroid Use Among Non Intercollegiate Athlete Males Ages 18-30, Vitesh Enaker

Theses and Dissertations--Kinesiology and Health Promotion

The purpose of this study was to increase understanding of factors associated with nonmedical anabolic steroid use among males ages 18-30 who do not participate in intercollegiate athletics. The Behavioral Intentions and Ergogenic Aid/Performance Enhancer use among non-intercollegiate athlete males survey instrument was developed, reviewed for content validity by a jury of experts, and pilot tested. The pilot testing results (n=25) demonstrated acceptable reliability (Cronbach’s alpha= 0.74). The final version of the Behavioral Intentions and Ergogenic Aid/Performance Enhancer use among non-intercollegiate athlete males survey instrument was administered at two distribution sites which included Ford’s Fitness Center in Lexington, Kentucky and …


Biological Control Of Manganese In Water Supplies In The Presence Of Humic Acids, Michael S. Snyder Jan 2013

Biological Control Of Manganese In Water Supplies In The Presence Of Humic Acids, Michael S. Snyder

Theses and Dissertations--Civil Engineering

The main objective of this study was to improve our understanding of biological filtration (biofilm type) treatment for manganese (Mn) removal in drinking water. Biological filtration treatment involves biofilms of Mn(II)-oxidizing microorganisms attached to solid filter material that remove and immobilize dissolved Mn(II) in raw water by conversion to black MnO2(s) precipitates. Mn-biological filtration is an emerging green technology that can serve as an alternative to conventional physicochemical treatments but its full potential is hindered by various factors. These include lack of understanding the: (1) optimal removal conditions for Mn, (2) mechanisms for Mn releases of the accumulated Mn …


Noninvasive Near-Infrared Diffuse Optical Monitoring Of Cerebral Hemodynamics And Autoregulation, Ran Cheng Jan 2013

Noninvasive Near-Infrared Diffuse Optical Monitoring Of Cerebral Hemodynamics And Autoregulation, Ran Cheng

Theses and Dissertations--Biomedical Engineering

Many cerebral diseases are associated with abnormal cerebral hemodynamics and impaired cerebral autoregulation (CA). CA is a mechanism to maintain cerebral blood flow (CBF) stable when mean arterial pressure (MAP) fluctuates. Evaluating these abnormalities requires direct measurements of cerebral hemodynamics and MAP. Several near-infrared diffuse optical instruments have been developed in our laboratory for hemodynamic measurements including near-infrared spectroscopy (NIRS), diffuse correlation spectroscopy (DCS), hybrid NIRS/DCS, and dual-wavelength DCS flow-oximeter. We utilized these noninvasive technologies to quantify CBF and cerebral oxygenation in different populations under different physiological conditions/manipulations. A commercial finger plethysmograph was used to continuously monitor MAP. For investigating …


Water Quality Sensor Placement Guidance For Small Water Distribution Systems, Stacey L. Schal Jan 2013

Water Quality Sensor Placement Guidance For Small Water Distribution Systems, Stacey L. Schal

Theses and Dissertations--Civil Engineering

Water distribution systems are vulnerable to intentional, along with accidental, contamination of the water supply. Contamination warning systems (CWS) are strategies to lessen the effects of contamination by delivering early indication of an event. Online quality monitoring, a network of sensors that can assess water quality and alert an operator of contamination, is a critical component of CWS, but utilities are faced with the decision of what locations are optimal for deployment of sensors. A sensor placement algorithm was developed and implemented in a commercial network distribution model (i.e. KYPIPE) to aid small utilities in sensor placement. The developed sensor …


Indiana's Southern Senator: Jesse Bright And The Hoosier Democracy, John J. Wickre Jan 2013

Indiana's Southern Senator: Jesse Bright And The Hoosier Democracy, John J. Wickre

Theses and Dissertations--History

Without northern doughface Democrats, and northern states like Indiana, the South could not have held dominance in American politics during the sectional crisis. Anchoring the extreme end of the doughface North was Indiana’s slaveholding senator Jesse Bright (his holdings were in Kentucky). Yet, he was no flailing radical pushed to the margins of northern politics. Bright was the chief party boss who by the mid to late 1850s controlled the state of Indiana. He was one of the most influential leaders getting James Buchanan into the presidency. He did this, in part, because Indiana was a conservative state that disliked …


More Than An "Immoderate Superstition": Christian Identity In The First Three Centuries, Edward Mason Jan 2013

More Than An "Immoderate Superstition": Christian Identity In The First Three Centuries, Edward Mason

Theses and Dissertations--History

Only recently have scholars given particular attention to the development of the racial discourse present in early Christian apologetics. This study is aimed at understanding the Latin and Greek literary antecedents to the development of a Christian discourse on race and identity and examining in detail the apex of this discourse in the work of third century apologist Origen of Alexandria. Origen’s work represented the apex of an evolving discourse that, while continuing to use traditional vocabulary, became increasingly universalizing with the growth of the Roman Empire. By understanding how Christians in the first three centuries shaped their attitudes on …


The Causes And Consequences Of Individual Variation In Parental Care Behavior, Daniel P. Wetzel Jan 2013

The Causes And Consequences Of Individual Variation In Parental Care Behavior, Daniel P. Wetzel

Theses and Dissertations--Biology

Behavioral traits can be remarkably flexible depending on the conditions in which they are expressed, yet, in spite of this flexibility, persistent differences between individuals appear to limit the potential expression of behaviors. For example, despite evidence that parents provide variable amounts of parental care in response to changing environmental conditions, they also differ in the overall level of care they provide. I used a behavioral reaction norm approach to study individual variation in parental care behavior in free-living house sparrows (Passer domesticus). I investigated the nature of this variation by studying the relationship between different forms of …


Axolotl Paedomorphosis: A Comparison Of Juvenile, Metamorphic, And Paedomorphic Ambystoma Mexicanum Brain Gene Transcription, Carlena Johnson Jan 2013

Axolotl Paedomorphosis: A Comparison Of Juvenile, Metamorphic, And Paedomorphic Ambystoma Mexicanum Brain Gene Transcription, Carlena Johnson

Theses and Dissertations--Biology

Unlike many amphibians, the paedomorphic axolotl (Ambystoma mexicanum) rarely undergoes external morphological changes indicative of metamorphosis. However, internally, some axolotl tissues undergo cryptic metamorphic changes. A previous study examined interspecific patterns of larval brain gene expression and found that these species exhibited unique temporal expression patterns that were hypothesized to be morph specific. This thesis tested this hypothesis by examining differences in brain gene expression between juvenile (JUV), paedomorphic (PAED), and metamorphic (MET) axolotls. I identified 828 genes that were expressed differently between JUV, PAED, and MET. Expression estimates from JUV were compared to estimates from PAED and …


The Contribution Of Two Related Bbp-Binding Gyf Proteins, Smy2 And Syh1, To Cellular Rna Abundance And Genome Stability, Min Chen Jan 2013

The Contribution Of Two Related Bbp-Binding Gyf Proteins, Smy2 And Syh1, To Cellular Rna Abundance And Genome Stability, Min Chen

Theses and Dissertations--Biology

Nuclear precursor of mature messenger RNA (pre-mRNA) splicing is one of the most highly regulated processes in eukaryotic organisms. In addition to its role in the removal of constitutive or alternative introns present in the pre-mRNA, splicing is also highly integrated into other layers of gene expression. This study investigates the potential role of the nuclear branchpoint binding protein (BBP) outside of the pre-mRNA splicing cycle. More specifically, we were interested in the biological relevance of its association with two cytoplasmic proteins Smy2 and Syh1. Smy2 and Syh1 belong to the GYF family of poly-proline binding proteins, and their roles …


Distribution And Impacts Of Petroleum Hydrocarbons In Louisiana Tidal Marsh Sediments Following The Deepwater Horizon Oil Spill, Rachel S. Hatch Jan 2013

Distribution And Impacts Of Petroleum Hydrocarbons In Louisiana Tidal Marsh Sediments Following The Deepwater Horizon Oil Spill, Rachel S. Hatch

Theses and Dissertations--Earth and Environmental Sciences

Following the 2010 Deepwater Horizon (DWH) spill, sediment cores were analyzed from marshes at various levels of oiling to determine how deeply oil penetrated sediment in these marsh environments, and if at these sites it had quantifiably affected benthic ecosystems. Minimum mixing depths were determined from penetration of the lithogenic radionuclide 234Th, which ranged from 0.25 to 4.5 cm. Sediment accumulation rates were determined using 210Pb, with verification from 137Cs in selected cores. Lead-210 profiles revealed long-term (decadal) mixing. Bay Jimmy, Louisiana was significantly affected by the DWH oil spill, as indicated by total polycyclic aromatic hydrocarbon …


A Children’S Geography Of Occupation: Imaginary, Emotional, And Everyday Spaces Of Palestinian Childhood, David J. Marshall Jan 2013

A Children’S Geography Of Occupation: Imaginary, Emotional, And Everyday Spaces Of Palestinian Childhood, David J. Marshall

Theses and Dissertations--Geography

This research examines the political geographies of Palestinian children, and the ways in which their everyday spaces and practices are shaped by broader social and political processes. This research begins with an investigation into the role of the child in the moral geopolitics of humanitarianism and the Palestinian/Israeli conflict. From here, the research explores how the competing discourses of Palestinian nationalism and international humanitarianism, and the legacy of forced migration, have shaped the subjectivity of Palestinian children and the spaces of childhood in a West Bank refugee camp, from homes, to schools, streets, and youth centers. Finally, using participant observation, …


Ecological Restoration's Genetic Culture: Participation And Technology In The Making Of Landscapes, Jairus Rossi Jan 2013

Ecological Restoration's Genetic Culture: Participation And Technology In The Making Of Landscapes, Jairus Rossi

Theses and Dissertations--Geography

Practitioners of ecological restoration are increasingly adopting a genetic perspective when recreating historical landscapes. Genes are often endowed with the capacity to reveal specific and distinct relationships between organisms and environments. In this dissertation, I examine how genetic technologies and concepts are shaping ecological restoration practices. This research is based on two and a half years of fieldwork in Chicago. I employed participant observation and semi-structured interviews to compare how restorationists in two plant science institutions employ genetic concepts in their projects. One institution uses high-tech genetic methods to guide practice while the other uses lower-tech genetic approaches. Each group …


The Process Of Learner Centered Instruction In Adult Clientele, Shannon W. Farrell Jan 2013

The Process Of Learner Centered Instruction In Adult Clientele, Shannon W. Farrell

Theses and Dissertations--Community & Leadership Development

Using learner centered instruction (LCI), a group of beef farmers were guided to design a farm in a layout that would most effectively offer continual learning opportunities for the beef practitioners themselves. Learner centered instruction was used as the primary teaching method for the project's completion. When using LCI, coupled with the correct facilitation of programs, student empowerment, and subject interest, positive experiences are more likely to result.


Identifying Risk And Protective Factors Of Preparatory And Non-Preparatory Students In Agricultural Education Programs Of A Rural Kentucky High School, Randy J. Adams Jan 2013

Identifying Risk And Protective Factors Of Preparatory And Non-Preparatory Students In Agricultural Education Programs Of A Rural Kentucky High School, Randy J. Adams

Theses and Dissertations--Community & Leadership Development

Today there is an increased demand for secondary agriculture education programs to prepare students to be college and career ready through a program of study. The purpose of this study was to identify risk and protective factors of preparatory and non-preparatory students within an agriculture education program at Anderson County High School in Lawrenceburg, Kentucky. The results of this study did not determine that there was a difference in risk and protective factors between preparatory and non-preparatory students within agriculture education courses. The study concluded that students among both categories were equally exposed to risks such as family conflict and …


Analyzing Healthy, Local Food Systems: A Case Study Of Owensboro, Kentucky, Callie Hayden Jan 2013

Analyzing Healthy, Local Food Systems: A Case Study Of Owensboro, Kentucky, Callie Hayden

Theses and Dissertations--Community & Leadership Development

Across the US, support is ever-growing for the local food movement. This growing trend promotes food security, supports farming families, ensures universal access to safe and healthy food products, enhances local economies, and encourages environmental and social well-being. People around the US are implementing sustainable local food systems as a means of meeting their individual community’s needs. While this movement is being popularized dramatically around the world, many cities and regions have yet to address it. This study reviews the existing literature on local food system models in an effort to answer the research question: What are the “ingredients” of …


Investigation Of Media Ingredients And Water Sources For Algae Co2 Capture At Different Scales To Demonstrate The Correlations Between Lab-Scale And Large-Scale Growth, Tabitha Graham Jan 2013

Investigation Of Media Ingredients And Water Sources For Algae Co2 Capture At Different Scales To Demonstrate The Correlations Between Lab-Scale And Large-Scale Growth, Tabitha Graham

Theses and Dissertations--Biosystems and Agricultural Engineering

As energy use increases globally the environmental burdens increase alike. Many accusations have been made that carbon dioxide is a culprit of climate change. The University of Kentucky and Duke Energy Power have partnered to test carbon capture technology in a large scale project. To this end, the objective of this thesis is to investigate potential water media sources and nutrient sources at different volume scales for algae cultivation to help create a more environmentally viable and economically feasible solution. This work will conduct a life cycle assessment of water media sources and the effects of the inputs and outputs …


Alkaline Hydrogen Peroxide Pretreatment For Its Use In An On-Farm Bioprocessing Facility, Mary Kathryn Gray Jan 2013

Alkaline Hydrogen Peroxide Pretreatment For Its Use In An On-Farm Bioprocessing Facility, Mary Kathryn Gray

Theses and Dissertations--Biosystems and Agricultural Engineering

Pretreatment is an essential step in biofuel production from lignocellulose. Disruption of the lignin structure gives enzymes and fermentation organisms access to long chains of cellulose and hemicellulose. For this project’s purposes, the pretreatment must work within the framework of an on-farm butanol bioprocessing facility. Alkaline hydrogen peroxide (AHP) is a delignification method that potentially provides several advantages. At the alkaline pH, powerful hydroxyl radicals are formed; which attack lignin. The objectives of this study were to determine if AHP removes substantial lignin for the feedstocks, corn stover, wheat straw, switchgrass and miscanthus, and to determine if AHP acts as …


Sodium Hydroxide Pretreatment Of Corn Stover And Subsequent Enzymatic Hydrolysis: An Investigation Of Yields, Kinetic Modeling And Glucose Recovery, Alicia Modenbach Jan 2013

Sodium Hydroxide Pretreatment Of Corn Stover And Subsequent Enzymatic Hydrolysis: An Investigation Of Yields, Kinetic Modeling And Glucose Recovery, Alicia Modenbach

Theses and Dissertations--Biosystems and Agricultural Engineering

Many aspects associated with conversion of lignocellulose to biofuels and other valuable products have been investigated to develop the most effective processes for biorefineries. The goal of this research was to improve the efficiency and effectiveness of the lignocellulose conversion process by achieving a more basic understanding of pretreatment and enzymatic hydrolysis at high solids, including kinetic modeling and separation and recovery of glucose.

Effects of NaOH pretreatment conditions on saccharide yields from enzymatic hydrolysis were characterized in low- and high-solids systems. Factors associated with pretreatment and hydrolysis were investigated, including duration of pretreatment at different temperatures and NaOH loadings, …


Hydrologic Characterization Of A Rain Garden Mitigating Stormwater Runoff From A Commercial Area, John T. Mcmaine Jan 2013

Hydrologic Characterization Of A Rain Garden Mitigating Stormwater Runoff From A Commercial Area, John T. Mcmaine

Theses and Dissertations--Biosystems and Agricultural Engineering

Impervious surfaces such as roads, sidewalks, and roofs increase the volume of runoff generated in a watershed. Traditional stormwater management techniques emphasize conveyance of runoff away from impervious surfaces in order to reduce flooding. Rain gardens are becoming popular as a different means to manage stormwater in such a way that runoff is captured and infiltrated onsite rather than conveyed offsite. A stormwater management system consisting of a rainwater harvest system, rain garden, and infiltration chamber was built at the Coca-Cola Refreshments USA, Inc. distribution center in Lexington, Kentucky during the fall of 2011. Precipitation, inflow, and water level were …


Nutrients Recycling Strategy For Microalgae-Based Co2 Mitigation System, Xinyi E Jan 2013

Nutrients Recycling Strategy For Microalgae-Based Co2 Mitigation System, Xinyi E

Theses and Dissertations--Biosystems and Agricultural Engineering

Coal-fired electricity production is the major emitter of CO2 and other greenhouse gases including NOx and SOx. Microalgae-based CO2 mitigation systems have been proposed to reduce the net CO2 emission from coal-fired power plants. This study focused on developing an optimum culture media and exploring the possibilities for recycling nutrients, which were added as commercial mineralized chemicals at the beginning of cultivation.

In order to release the nutrients embedded in the cells so that they can be used as a nutrient source for new cells, Scenedesmus biomass was digested by anaerobic bacteria. Results showed …


On T Cell Fate Decisions: Retinol, Metabolism And Itreg Differentiation, Gavin I. Ellis Jan 2013

On T Cell Fate Decisions: Retinol, Metabolism And Itreg Differentiation, Gavin I. Ellis

Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics

The mammalian immune system is equipped to both eliminate pathogenic microorganisms and tumors, while remaining in homeostasis with commensal species at mucosal surfaces and tolerant towards self. Suppressor regulatory T cells (Tregs) are a major sentinel of this immunological tolerance. Induced Tregs (iTregs) arise in the periphery following the integration of cues from the metabolites, cytokines, etc. which make up its milieu. Dysregulation of iTreg development, function or homing underlies the etiology of many autoimmune diseases and immunopathologies. The amelioration or prevention of multiple murine disease models by boosting Treg cell numbers foreshadows clinical efficacy of iTreg therapy, but an …


Effects Of Intranasally Administered Dnsp-11 On The Central Dopamine System Of Normal And Parkinsonian Fischer 344 Rats, James H. Sonne Jan 2013

Effects Of Intranasally Administered Dnsp-11 On The Central Dopamine System Of Normal And Parkinsonian Fischer 344 Rats, James H. Sonne

Theses and Dissertations--Neuroscience

Due to the blood-brain barrier, delivery of many drugs to the brain has required intracranial surgery which is prone to complication. Here we show that Dopamine Neuron Stimulating Peptide 11 (DNSP-11), following non-invasive intranasal administration, protects dopaminergic neurons from a lesion model of Parkinson’s disease in the rat. A significant and dose-dependent increase in an index of dopamine turnover (the ratio of DOPAC to dopamine) was observed in the striatum of normal young adult Fischer 344 rats by whole-tissue neurochemistry compared to vehicle administered controls.

Among animals challenged with a moderate, unilateral 6-hydroxy-dopamine (6-OHDA) lesion of the substantia nigra, those …


Molecular And Cellular Characterization Of Dopamine Neuron Stimulating Peptides, Kristen Kelps Jan 2013

Molecular And Cellular Characterization Of Dopamine Neuron Stimulating Peptides, Kristen Kelps

Theses and Dissertations--Neuroscience

Parkinson’s disease, the second most common neurodegenerative disease, is characterized by the loss of dopaminergic neurons within the substantia nigra. Currently, the treatments available for PD are symptomatic treatments that do not stop the progression of the disease. Trophic molecules, such as glial cell-line derived neurotrophic factor (GDNF), have been evaluated as potential therapeutic molecules that could stop the loss of neurons and potentially restore some of the neurons that have already been lost. However, these trophic molecules are large making them difficult to produce and delivery. Here we characterize three peptides (DNSP-5, DNSP-11, and DNSP-17) to determine it they …