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The Transition To Resilience: A Comparative Case Study Of Two Communities, John D. Johnson

Theses and Dissertations--Sociology

This dissertation examines the question of how communities understand their risk related to global economic and environmental problems and how communities respond to those risks. Specifically, using comparative case study, this dissertation examines the sustainability efforts of two communities, Oberlin, Ohio and Berea, Kentucky. Both communities have created advanced sustainability efforts over more than a decade of work and both communities have well-developed partnerships with the colleges in their communities. It finds that communities are responding to both global risks related to climate change and energy price volatility, but also are making efforts to resolve more localized social problems and …

Adp-Ribosylation Factor 6 (Arf6) Regulates Integrin Αiibβ3 Trafficking, Platelet Spreading, And Clot Retraction, Yunjie Huang

Theses and Dissertations--Molecular and Cellular Biochemistry

Endocytic trafficking of platelet surface receptors plays a role in the accumulation of granule cargo (i.e. fibrinogen and VEGF) and thus could contribute to hemostasis, angiogenesis, or inflammation. However, the mechanisms of platelet endocytosis are poorly understood. The small GTP-binding protein, ADP-ribosylation factor 6 (Arf6), regulates integrin trafficking in nucleated cells; therefore, we posited that Arf6 functions similarly in platelets. To address this, we generated platelet-specific, Arf6 knockout mice. Arf6^-/- platelets had a storage defect for fibrinogen but not other cargo, implying Arf6’s role in integrin αIIbβ3 trafficking. Additionally, platelets from Arf6^-/- mice injected with biotinylated-fibrinogen, showed …

Mechanisms Of Therapeutic Resistance In Castration Resistant Prostate Cancer, Sarah Katherine Martin

Theses and Dissertations--Molecular and Cellular Biochemistry

Taxane based chemotherapy is an effective treatment for castration-resistant prostate cancer (CRPC) via stabilization of microtubules. Progression to castration-resistant prostate cancer is characterized by increased androgen receptor (AR), elevated intra-prostatic androgens and activated AR signaling despite castrate levels of androgens.

Previous studies identified that the inhibitory effect of microtubule targeting chemotherapy on AR activity was conferred by interfering with AR intracellular trafficking. The N-terminal domain (NTD) of AR was identified as a tubulin interacting domain that can be effectively targeted by the novel small molecular inhibitor, EPI. Taken together, this evidence provided the rationale that targeting AR nuclear translocation and …

The Role Of Phlpp In Pancreatic Cancer, Alena J. Smith

Theses and Dissertations--Molecular and Cellular Biochemistry

Medicine has come a long way in recent years with reliable treatments for many cancers. Pancreatic ductal adenocarcinoma (PDAC) has very few treatment options available. PDAC has a dismal 5 year survival rate of 4% and a median survival span of 6 months from point of diagnosis; with a high rate of chemotherapy and radiation resistance. A better understanding of the molecular events leading to cancer progression is needed in order to improve the treatment and prognosis of PDAC patients. We begin to elucidate the functional importance of PHLPP on suppressing progression and metastasis of PDAC. PHLPP belongs to a …

Production, Persistence And Diversity Of Species In Temperate Grasslands, Meredith L. Mitchell, Brendan P. Christy

IGC Proceedings (1977-2023)

Temperate grassland areas are considered to be semi-arid, with rainfall typically between 250 and 500 mm, much of it occurring in the late spring and early summer. Grazing plays an important role in all these grasslands with impacts on diversity and persistence. Against this assumption that seasonal productivity would be more uniform within a pasture that was diverse, the research suggested that species rich pastures were less stable, because this species richness was composed of non-perennial, volunteer and weed species. This paper explores the concept that systems diversity of temperate grassland does not always equate to production. In these systems …

Using Various Lactic Acid Bacteria Strains During Forage Conservation Towards Fermentation, Storage, Nutritive Value And Safety Improvement, Jonas Jatkauskas, Vilma Vrotniakiene

IGC Proceedings (1977-2023)

Many research efforts have been devoted to find ways how to produce silages with maximum nutritive value, good fermentation and low mould and yeast counts. While there are different objectives in using silage additives, the main objectives are to improve fermentation and reduce dry matter loss, and to prevent secondary fermentation at feed out time. This paper presents our most significant and recent investigations on forage inoculation before ensiling that have a potential for beneficial application on grassland and ruminant nutrition.

Traditional Livestock Production And Growth Opportunities In India, S. M. Deb

IGC Proceedings (1977-2023)

Livestock and animal health development projects need to be based on an understanding of livestock production systems because different systems need different approaches particularly in view of degradation of environment combined with population pressure. In India, the livestock production system is primarily traditional, consisting of mixed-farming and pastoral systems, therefore, development of marginal and smallholder mixed farms must aim at intensification of the total production system. Resource-poor farming systems may aim at the improved management of the various livestock species in backyards. Pastoral systems must focus on effective management of grazing pressure. Community pasture management involves application of technologies, land …

Nutrient Movements Through Ruminant Livestock Production Systems, Adegbola T. Adesogan, Jose C. B. Dubeux, Lynn E. Sollenberger

IGC Proceedings (1977-2023)

Considerable attention has been paid to reducing nutrient emissions from ruminant livestock in the last few decades. This area will continue to attract considerable research in the future due to increasing farm sizes in some developed countries as well as the increasing demand for meat and dairy products, particularly in developing countries. This paper discusses the deposition and losses of carbon and nitrogen in soils and plants in grazed and harvested forage systems as well as utilization and losses of both nutrients by ruminants in both systems. The paper also outlines several soil, plant, and animal-focused strategies that can be …

Rainwater Harvesting And Its Impact On Farming Systems, J. S. Samra

IGC Proceedings (1977-2023)

Landless, small holders and other poors supplement their livelihood and adapt to climate change by grazing, stall feeding with crop residues and fodder cultivated under rainfed and irrigated conditions. Improving productivity by conserving rainfall, ground water recharging, harvesting and recycling of rainwater especially in degraded open access or shared land with community participation was quite successful over a wide range of precipitation and ecological situations. Various types of trenches, bunding, vegetative barriers, gully plugs, ponds, check dams, land slides and mine spoils stabilization etc. retained more soil moisture, seeds, vegetative propagules etc. in situ and prevented soil erosion. It regenerated …

Strengthening Livelihood Of Rural Farmer Populations Through Improved Grasslands, Sujatha Premaratne, S. C. Somasiri

IGC Proceedings (1977-2023)

This paper reviews the current background of the grassland resource with a purpose of livestock perspective to improve the livelihood of rural farmers. The use of grasslands for livestock rearing by rural farmers has been a long tradition. In climate and vegetation contrast, these grasslands are much more diverse. They are likely to play an economical role in increasing the milk production in many Asian countries. With an increase of human population, the traditional feeding, breeding and surviving habitats for livestock have been acutely restricted in many countries. Therefore, a continued effort is needed to maintain production for sustainable management …

Problems And Prospects Of Grassland Development: Policy Issues, S. Ray Smith

IGC Proceedings (1977-2023)

There are a range of government and non-government policies that affect grassland development around the world. The objective of this paper is to provide examples of successful policies which have been instrumental in the preservation and maintenance of grasslands and to highlight policies which have resulted in negative consequences. This paper will not attempt to provide a complete overview of policies, but instead will provide examples from representative countries. Policies which affect grasslands can be classified into two broad categories: government policies that cover comprehensive landscape issues like the Grassland Household Contract System (GHCS) in China or the Federal Land …

Management Of Grazing Lands Through Educating Communities, D. Ariungerel, Graeme Hand, Annabel Walsh

IGC Proceedings (1977-2023)

The Mongolian steppe is one of the world’s largest grassland and it is an arid to semiarid land with a strong climate gradient. Biodiversity loss leading to desertification and land degradation is estimated to be impacting around 65% of the total area of Mongolia. The preliminary objective of this project was to trial the Positive Deviance Methodology to determine if this method assists herders to design behaviors to reverse this biodiversity loss. This project is a partnership between Mongolian Herders, Mongolian rangeland scientists and Australian based Stipa Native Grasses Association. The Positive Deviance Methodology has five basic steps based around …

Livestock And Local Development: Going To A New Humananimal Relationship, Jean François Tourrand, Laurent Dobremez, Benoit Dedieu, Guillaume Duteurtre, M. G. Piketty, P. Lescoat, B. Hubert

IGC Proceedings (1977-2023)

Along the past ten years, the French National Agency for Research (ANR) has financed projects regarding livestock. Results of five projects were gathered to understand the long-term livestock trends. At the end of the 19th century, animal breeding was oriented towards the production of goods to meet the local, regional, national and global demand, according to the zone. The market gradually became the key-factor to norm both production and consumption. It is now integrating environmental norms and is starting to invest in the social domain. However, this economical vision of animal production does not take into account the other functions …

Genomic Approaches For Dissecting Complex Traits Related To Quality Production Of Range Grasses, Masumi Ebina

IGC Proceedings (1977-2023)

Tropical grasses have been widely used as warm-season forage grasses in the warm temperate zone since the early 20th century because of their high yields; they have also been used as perennial forages in their native tropical areas. Increasing demand for animal production sparked by economic development in tropical countries is requiring breeders to improve native forage grasses in these countries. Considerable efforts have been made to breed accessions with improved characteristics and to develop new cultivars. However, cross-breeding is not common, owing to a lack of genetic information and to complexities related to polyploidy, high sterility rates, outcrossing, and …

Emission Of Green House Gases From Grasslands And Their Mitigation, Prem N. Sharma, Shyam Khadka

IGC Proceedings (1977-2023)

The concentrations of green house gases (GHG) in the atmosphere began in pre-industrial times and it continues to increase. This could result into an alarming increase in temperature of up to 5.4 ^oC by year 2100 due to a net global annual GHG emission of H 4.5-6.5 Gt C equivalent. About 18% of the world’s GHG are contributed by livestock and related activities on grasslands that are spread over almost 35 million Km².These grasslands give livelihood to over a billion people most of who are poor. Twenty to 70% of the land surface area is degrading often …

High-Altitude Grassland Management And Improvement Of Pastoral Livelihoods In The Hindu Kush Himalayan Region, Eklabya Sharma

IGC Proceedings (1977-2023)

The Hindu Kush Himalayan (HKH) region is the largest mountain systems in the world, spanning over 4.3 million km2 and covering 3500 km long fragile environment. Grasslands in the HKH region are the source of livelihoods for approximately 25 to 30 million pastoralists and agro-pastoralists. High altitude grasslands play a significant role in storage and regulation of water; storage of carbon in soil and peat lands; permafrost storage; and stabilization of climate, soil, and nutrients. They foster a rich biodiversity with endemic species of fauna and flora; provide clean air and open spaces for recreational purposes, and bolster a rich …

Physiological Function Of Fus: An Rna Binding Protein In Motor Neuron Disease, Liuqing Yang

Theses and Dissertations--Molecular and Cellular Biochemistry

FUS is an RNA binding protein implicated in the motor neuron disease— amyotrophic lateral sclerosis (ALS, also called Lou Gehrig’s disease). ALS is a fatal neurodegenerative disease characterized by progressive motor neuron death. Mutations in the FUS gene cause about 4% of familial ALS (FUS ALS). Mutated FUS protein mislocalizes from the motor neuron nucleus to the cytoplasm and forms inclusions in the cytoplasm. It is unclear how FUS mislocalization induces motor neuron dysfunction and degeneration. This dissertation research was designed to investigate the physiological functions of FUS in the nucleus, with a purpose to shed light on the pathogenesis …

Physical Interactions Between Neuropilin And Vegfrs, Integrins In Regulating Endothelial Cell Functions, Xiaobo Li

Theses and Dissertations--Molecular and Cellular Biochemistry

The neuropilin (Nrp) family consists of multifunctional cell surface receptors with critical roles in a number of different cell and tissue types. A core aspect of Nrp function is ligand-dependent cellular adhesion and migration, where it controls the multistep process of cellular motility through integration of ligand binding, receptor coupling and signaling via the coordinated action of its extracellular and intracellular domains. While Nrp regulates cellular adhesion and motility in the cardiovascular and nervous systems under physiological conditions, the emerging pathological role of Nrp in tumor cell migration and metastasis has been identified and provides motivation for continued efforts toward …

Beryllium Nitrate Supports Fibroblast Migration As An Essential Component Of Skin And Limb Regeneration In Axolotls, Adam Boyd Cook

Theses and Dissertations--Biology

Tissue regeneration in salamanders is a robust process that is not easily interrupted or altered. Therefore, inhibiting regeneration provides a means to interrogate the underlying cellular and molecular mechanisms regulating this complex event. Here we show that application of a relatively low concentration of beryllium nitrate solution (100mM) causes a delay in skin regeneration and severely alters normal limb regeneration. We provide evidence showing a beryllium-induced reduction in dermal fibroblast migration in vivo and in vitro. We link this phenomenon to delayed regeneration of the skin and abnormal blastema formation resulting in limb patterning defects during regeneration. Though our …

Role Of Sox11 During Vertebrate Ocular Morphogenesis And Retinal Neurogenesis, Lakshmi Shashidharan Pillai

Theses and Dissertations--Biology

Microphthalmia, anophthalmia, and coloboma (MAC) are distinct abnormalities demonstrating a continuum of developmental eye defects that contribute to 15-20% of blindness and severe vision deficiencies in children worldwide. The genetic etiology of MAC is large, complex and encompasses the whole developmental biology of the eye. Understanding how the eye develops will aid in identifying genes and developmental pathways involved in MAC. Although investigation of the genetic architecture of congenital anomalies is growing exponentially, much work remains to be accomplished to understand the complex, genetically heterogeneous congenital anomalies, which significantly impact childhood vision.

With an interest in elucidating the mechanisms that …

Context-Dependent Individual Variation In Foraging Behaviour And Parental Care In House Sparrows, David Moldoff

Theses and Dissertations--Biology

Behaviors can exhibit a wide degree of plasticity depending on the environmental context in which they are expressed. Despite this, repeatable differences have been found among and within individuals across a wide range of taxa. For my thesis, I investigated individual differences in foraging and parental care. In the first experiment, I assessed house sparrows (Passer domesticus) for domain-generality among neophobia, habituation and associative learning as they are all responses to novelty. While the results of the study find individual differences in each of these contexts the conclusion supported separate mechanisms for each response (domain-specificity). In the second experiment, I …

Dual Functions For Insulinoma-Associated 1 In Retinal Development, Marie A. Forbes-Osborne

Theses and Dissertations--Biology

Proper visual system function requires tightly controlled proliferation of a pool of relatively homogeneous retinal progenitor cells, followed by the stepwise specification and differentiation of multiple distinct cell types. These retinal cells, both neuronal and glial, must be generated in the correct numbers, and the correct laminar location to permit the formation of synaptic connections between individual cell types. After synapses are made, constant signaling is required as part of normal retinal function, and to maintain cellular identity and connectivity. These processes rely on both extrinsic and intrinsic signaling, with regulation of gene expression by cascades of transcription factors having …

Animal And Pasture Responses To Grazing Management Of Chemically Suppressed Tall Fescue In Mixed Pastures, Jessica A. Williamson

Theses and Dissertations--Plant and Soil Sciences

Treatment of endophyte-infected tall fescue [Lolium arundinaceum (Schreb.) Darbysh] with the broad leaf herbicide Chaparral® can mitigate fescue toxicosis and enhance forage quality by suppressing seedhead emergence. Applying the herbicide to fescue pastures also reduces forage mass and promotes severe spot grazing when pastures are continuously grazed. A grazing experiment was conducted with steers (2013) and heifers (2014) to evaluate animal and plant responses in fescue-bluegrass (Poa pratensis L.) mixtures treated with Chaparral to determine the effects of grazing management on pasture carrying capacity, nutritive values, botanical composition, and animal performance. Continuous and rotational (i.e., four subdivisions to …

Investigations Into The Home Lawn Carbon Balance And Improving The Efficacy Of T-Phylloplanins For Combating Turfgrass Diseases, Kenneth L. Cropper

Theses and Dissertations--Plant and Soil Sciences

Over the past couple of decades, there has been an increased interest in evaluating the environmental impacts of some turfgrass management practices. Two independent studies were conducted to examine different questions of turfgrass management impacts and sustainability. The first study examined the inputs and outputs of four different turfgrass home lawn systems. Two of these systems were designated as high maintenance and were composed of either a pure stand of Kentucky bluegrass (Poa pratensis L.) or tall fescue (Festuca arundinacea Schreb.). The other two systems were designated as low maintenance and were composed of either a pure stand …

Evaluation Of Input-Intensive Soybean Management Systems And The Effect Of Lactofen Application On Soybean Physiology, John M. Orlowski

Theses and Dissertations--Plant and Soil Sciences

In an effort to maximize yields, many soybean growers have begun moving to intensive, input-based soybean management systems. However, limited reliable information exists about the effect of these inputs on soybean yield. The purpose of this study was to evaluate the effect of individual inputs and combinations of inputs as part of high-yield management systems on soybean seed yield and to determine the effect of one of these inputs, lactofen, on soybean physiology. Small plot studies were established in nine states across the Midwest. A number of commercially available soybean inputs were evaluated individually and in combination to determine their …

Examining Vegetative Growth Of Cool-Season Forage Grasses For Dairy Cattle Grazing Preference, Eric D. Billman

Theses and Dissertations--Plant and Soil Sciences

The objective of this study was to determine dairy cattle preference amongst four species of cool-season forage grasses: eight orchardgrasses (Dactylis glomerata L.), five tall fescues [Schedonorus arundinaceus (Schreb.) Dumort.], five perennial ryegrasses (Lolium perenne L.), and six festuloliums [xFestulolium braunii (K. Richt.) A. Camus.]; 24 cultivars in total. Each grazing trial utilized four Holstein-Friesian heifers over six hours. Maturity differences were eliminated by having animals graze only vegetative material. After six grazing trials (three each in 2014 and 2015), consistent results in animal preference were not found; three of the six trials did show preference …

Self-Management Education In Hispanic Women With Gestational Diabetes Mellitus (Gdm), Laura B. Hieronymus

DNP Projects

The purpose of this Practice Inquiry Project was to develop, implement, and evaluate the effectiveness of a diabetes self-management education intervention in a population of Hispanic women at risk for gestational diabetes mellitus within a CenteringPregnancy(R) model of care.

Measuring Adherence To Evidence-Based Practice Guidelines For The Management Of Hypertension In Women, Cristina M. Jorgensen

DNP Projects

Approximately 1 in 3 adults In the United States (U. S.) with approximately half being women have hypertension, a significant risk factor for cardiovascular disease (CVD) and stroke (Nwankwo, Yoon, Burt, & Gu, 2013). Nearly 70% of people who had a first heart attack, 80% of those who had a first stroke, and 75% of those who had congestive heart failure (CHF) have hypertension (Mozaffarian et al., 2013). Hypertension was the underlying or contributing cause of more than 375,000 deaths in 2011. Despite multiple publications of national hypertension guidelines, only 50% of adults with hypertension have their blood pressure under …

Prenatal Anxiety And Cesarean Delivery In A Clinic Population, Carol A. Kirby

DNP Projects

Although there is an abundance of literature on the topics of prenatal anxiety, stress, depression, etc. during pregnancy, very little research has been conducted on the impact of prenatal anxiety on cesarean delivery and the studies which have been conducted have resulted in conflicting results. This study focused on prenatal anxiety in a clinical population, the characteristics of participants with reported high anxiety, and its association with cesarean deliveries. Prenatal anxiety was defined as Spielberger’s state anxiety and measured with the STAI. Data was collected over all three trimesters of pregnancy and post-delivery. The characteristics of participants who reported high …

Assessment Of Patient Barriers To And Facilitators Of Screening Colonoscopy: Utilizing Patient Perspectives To Formulate Recommendations To Improve Colorectal Cancer Screening Rates, Heather N. Cox

DNP Projects

A pilot study was conducted that utilized focused patient interviews to determine patient barriers to and facilitators of screening colonoscopy. The interviews were transcribed and systematically analyzed to detect recurring patterns and themes related to screening colonoscopy completion or lack thereof. Descriptive statistics were used to summarize additional sample characteristics such as gender, education level, and income level. Among those who had received a screening colonoscopy (44%, 11 of 25), provider recommendation was the most influential factor for procedure completion, followed by the combination of provider plus family member recommendation. Additional findings revealed that due to medical necessity, several patients …