Digital Commons Network^™

Learning To Write In An Academic Genre: Adult English Learners’ Use Of Sociocultural Resources, Lyudmyla Ivanyuk

Theses and Dissertations--Curriculum and Instruction

In this multiple case study, I examined what types of sociocultural resources adult English learners brought with them from their previous contexts and what new resources they drew upon in the U.S. while learning to write in the essay genre. The study also identified how the participants chose to use previous and new sociocultural resources as mediated by the essay genre in the U.S. The following research foci shaped this study: (1) What types of sociocultural resources do adult English learners use while learning to write in the essay genre prior to and after their arrival in the U.S.? (2) …

Residual Next-Day Effects Of Alprazolam On Psychomotor Performance And Simulated Driving In Healthy Normal Volunteers, Marion A. Coe

Theses and Dissertations--Pharmacology and Nutritional Sciences

The prevalence of drugged driving has increased in the United States, and some prescription medications (e.g., zolpidem) cause impairment after the predicted duration of therapeutic action has elapsed. The aim of this study is to determine if bedtime administration of alprazolam similarly impacts driving performance the following day.

Volunteers were 14 healthy adults (6 males) who completed a double-blind, double-dummy within-subjects design study examining the effects of alprazolam (0.5, 1, & 2mg), zolpidem (10mg), and placebo administered at bedtime on driving performance the following day. The positive control condition was alprazolam (1mg) administered on the test morning. Driving simulator measures, …

Evaluating The Efficacy Of Systematic Patient Feedback In An Integrated Mental Health And Primary Care Setting, Alex Lengerich

Theses and Dissertations--Educational, School, and Counseling Psychology

The implementation of the Affordable Care Act (ACA, 2010) has resulted in efforts to make healthcare more affordable and effective. One strategy for making healthcare more affordable and effective is the integration of behavioral health and primary care. In today’s healthcare system, it is estimated that approximately one in three patients seen in a primary care setting meet the criteria for a mental health disorder and another third – while not meeting those criteria – are experiencing psychological symptoms that impair their functioning (Kessler, 2005). Despite the evidence supporting behavioral health services in a primary care setting, treatments tend to …

Evaluation Of Plan Quality And Treatment Efficiency For Single-Isocenter/Two-Lesion Lung Stereotactic Body Radiation Therapy, Lana Sanford, Janelle A. Molloy, Sameera S. Kumar, Marcus Randall, Ronald C. Mcgarry, Damodar Pokhrel

Radiation Medicine Faculty Publications

Purpose/objectives: To evaluate the plan quality and treatment delivery efficiency of single‐isocenter/two‐lesions volumetric modulated arc therapy (VMAT) lung stereotactic body radiation therapy (SBRT).

Materials/methods: Eight consecutive patients with two peripherally located early stage nonsmall‐cell‐lung cancer (NSCLC) lung lesions underwent single‐isocenter highly conformal noncoplanar VMAT SBRT treatment in our institution. A single‐isocenter was placed between the two lesions. Doses were 54 or 50 Gy in 3 and 5 fractions respectively. Patients were treated every other day. Plans were calculated in Eclipse with AcurosXB algorithm and normalized to at least 95% of the planning target volume (PTV) receiving 100% of the prescribed …

Forms Of Supplemental Selenium In Vitamin-Mineral Mixes Differentially Affect Serological And Hepatic Parameters Of Growing Beef Steers Grazing Endophyte-Infected Tall Fescue, Yang Jia

Theses and Dissertations--Animal and Food Sciences

Consumption of endophyte-infected tall fescue results in a syndrome of negatively altered physiological systems, collectively known as fescue toxicosis. Another challenge to endophyte-infected tall fescue -based beef cattle operations is that the soils often are selenium (Se) poor, necessitating the need to provide supplemental Se. To test the general hypothesis that different forms of supplemental Se would ameliorate the negative effects of fescue toxicosis, predominately-Angus steers (BW = 183 ± 34 kg) were randomly selected from herds of fall-calving cows grazing an endophyte-infected tall fescue pasture and consuming vitamin-mineral mixes that contained 35 ppm Se as sodium selenite (ISe), SELPLEX …

Evolution Of The Zhx Transcription Factor Family And Analysis Of Zhx2 Target Genes Cyp2a4 And Cyp2a5 In Mouse Liver, Alexandra Nichole Nail

Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics

The liver is the largest internal organ and performs a wide variety of functions to maintain organismal homeostasis. While some liver functions are carried out by all hepatocytes, other functions are restricted to certain populations of hepatocytes within the liver. This phenomenon, called zonal gene regulation or liver zonation, controls may metabolic processes within the liver including ammonia detoxification; glucose homeostasis; bile acid and glutamine synthesis; and metabolism of xenobiotics, lipids, and amino acids. The liver also expresses many genes in a developmental or sex-biased manner. Some genes are expressed at higher levels early or late in development, or alternatively, …

The Role Of Nrf2 Signalling In Cell Proliferation And Tumorigenesis Of Chromium Transformed Human Bronchial Epithelial Cells, Marco Antonio De Freitas Clementino

Theses and Dissertations--Toxicology and Cancer Biology

Hexavalent Chromium (Cr(VI) induces malignant cell transformation in normal bronchial epithelial (BEAS-2B) cells. Cr(VI)-transformed cells exhibit increased level of antioxidants, are resistant to apoptosis, and are tumorigenic. RNAseq analysis in Cr(VI)-transformed cells showed that expression of transcripts associated with mitochondrial oxidative phosphorylation is reduced, and the expression of transcripts associated with pentose phosphate pathway, glycolysis, and glutaminolysis are increased. Sirtuin-3 (SIRT3) regulates mitochondrial adaptive response to stress, such as metabolic reprogramming and antioxidant defense mechanisms. SIRT3 was upregulated and it positively regulated mitochondrial oxidative phosphorylation in Cr(VI)-transformed cells. Our results suggests that SIRT3 plays an important role in mitophagy deficiency …

A Compromised Liver Alters Pcb Toxicity And Nutrient Metabolism, Jazmyne D. L. Barney

Theses and Dissertations--Toxicology and Cancer Biology

Environmental contamination is a public health concern. In particular persistent organic pollutants like Polychlorinated Biphenyls (PCBs) have been associated with multiple chronic inflammatory diseases, including non-alcoholic fatty liver disease (NAFLD). NAFLD prevalence has steadily increased and is expected to continue to rise with an estimated 25% of the world’s population and 80-100 million people affected in the United States alone. Importantly, the liver is the primary site for endobiotic and xenobiotic metabolism, hence its proper function is critical for the body’s response to innate and extrinsic molecules. One way to combat the deleterious effects of PCB toxicity and fatty liver …

Social Networks, Identity, Health, And Quality Of Life Among Older Gay And Lesbian Individuals In Rural Environments, Marc Aaron Guest

Theses and Dissertations--Gerontology

The goal of this dissertation was to explore aging lesbian and gay individuals living in rural communities, in terms of their social networks and the relationships between these networks, identity, health, and quality of life. Guiding the study were three overarching questions. Using a multi-method design, the research was grounded within a socio-ecological context and focused on how structural systems create pathways for health and are affected by social position (intersectionality). Participants (n=25) were recruited from Kentucky (n=20), West Virginia (n=3), and Tennessee (n=2). Thirteen participants self-identified as gay and twelve as lesbian. Findings highlight the complexity of the aging …

Trade-Offs Shape Carotenoid-Based Color Variation In Redheaded Pine Sawfly (Neodiprion Lecontei) Larvae, Maranda Gaines

Lewis Honors College Capstone Collection

Carotenoids serve various ecological roles in animals including coloration, immune responses, and vision. Carotenoid-derived coloration is greatly emphasized in the literature, particularly relating to mate choice and aposematic warning. However, the trade-offs between the color and non-color functions of carotenoids are not thoroughly explored. In the redheaded pine sawfly (Neodiprion lecontei), some larval populations have yellow pigmentation, using carotenoids derived from their diets for aposematic warning coloration. Other larval populations are white in color, having genetically lost the ability to produce the yellow pigment. Because carotenoids are essential to life functions in both the yellow and white populations, we aim …

The First Step Toward The Future Of Wearables In Rehabilitation, Morgan L. Andrews

Lewis Honors College Capstone Collection

Tibial stress fractures are a major problem for runners and military athletes due to the high-intensity nature of their training. This injury is commonly treated through subjective measures including rest and management of symptoms that are evaluated by a therapist or trainer. With the advancement of technology such as inertial measurement units with accelerometers, clinicians may have the potential to provide an objective way to rehabilitate tibial stress fractures. Wearable technology is becoming more popular to be used in training but has not made it to rehabilitation yet. This study examines the validity of derived measures from the IMeasureU IMU …

Host Restriction Factors In The Replication Of Tombusviruses: From Rna Helicases To Nucleocytoplasmic Shuttling, Cheng-Yu Wu

Theses and Dissertations--Plant Pathology

Positive-stranded (+)RNA viruses replicate inside cells and depend on many cellular factors to complete their infection cycle. In the meanwhile, (+)RNA viruses face the host innate immunity, such as cell-intrinsic restriction factors that could block virus replication.

Firstly, I have established that the plant DDX17-like RH30 DEAD-box helicase conducts strong inhibitory function on tombusvirus replication when expressed in plants and yeast surrogate host. This study demonstrates that RH30 blocks the assembly of viral replicase complex, the activation of RNA-dependent RNA polymerase function of p92pol and viral RNA template recruitment.

In addition, the features rendering the abundant plant DEAD-box helicases either …

Sponge Spicule And Phytolith Evidence For Late Quaternary Environmental Changes In The Tropical Pantanal Wetlands Of Western Brazil, Giliane G. Rasbold, Michael M. Mcglue, José C. Stevaux, Mauro Parolin, Aguinaldo Silva, Ivan Bergier

Earth and Environmental Sciences Faculty Publications

The environmental history of the central Pantanal wetlands of western Brazil is inferred for the last 19 kyrs based on a multi-indicator paleolimnological analysis of a sediment core from Lake Negra. The core, dated by 14 C and OSL, shows variations in the abundance, diversity, and preservation of sponge spicules and phytoliths through time, consistent with changing aquatic environments. In the late Pleistocene, Lake Negra was influenced by a strong monsoon and fluvial depositional processes, whereas in the Holocene, there was a drier interval where the lake was more isolated on the floodplain. Hiatuses in the stratigraphy resulted from both …

Strain-Specific Protein Interaction And Localization Of Two Strains Of Potato Yellow Dwarf Virus And Functional Domains Of Their Matrix Protein, Chanyong Jang

Theses and Dissertations--Plant Pathology

Potato yellow dwarf virus (PYDV) is the type species of the genus nucleorhabdovirus which is typified by its nucleotropic characters of the members. The virus accomplishes its replication and morphogenesis in the nuclei of infected cells. Two strains, Constricta strain (CYDV) and Sanguinolenta strain (SYDV) have been described at the level of vector-specificity. CYDV is vectored by Agallia constricta and SYDV is transmitted by Aceratagllia sanguinolenta. The full-length genome of CYDV was sequenced. The 12,792 nt antisense genome encodes seven open reading frames in the order of, nucleocapsid protein (N), unknown protein (X), phosphoprotein (P), movement protein (Y), matrix …

Placing Our Wager On Equine Assisted Therapy For Kids: Utilizing Kentucky's Sb 200 Reinvestment Funds On Programs That Work, Amanda Mullins Bear

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Improved Iron Status In Weanling Pigs Leads To Improved Growth Performance In The Subsequent Nursery Period, Tyler Chevalier

Theses and Dissertations--Animal and Food Sciences

The objectives of this thesis were: 1) to assess the iron status of piglets, 2) to thoroughly evaluate the blood profile, growth performance, and tissue mineral concentration of young pigs during the pre and postweaning periods after receiving various dosages of iron (0, 50, 100, 200, and 300 mg iron) at birth, 3) as well as evaluate the effects of an additional iron injection before weaning on hematological measures, growth performance, and tissue mineral concentration postweaning. In the initial experiment, there was a 60% incidence of iron deficiency at weaning after administration of a 150 mg iron injection at birth. …

Effects Of Suv39h1 And Suv420h1/H2 On Programmed Genome Rearrangement In Petromyzon Marinus, Claire A. Scott

Oswald Research and Creativity Competition

The sea lamprey (Petromyzon marinus), diverged from the vertebrate lineage roughly 550 million years ago, prior to the evolution of several major morphological features such as jaws and paired fins/appendages. Lamprey therefore provides a comparative perspective that can be used to study the evolution of differences in genome regulation, including epigenetics and programmed genome rearrangement (PGR). Programmed genome rearrangement is a unique regulatory mechanism wherein specific genes are effectively turned off by completely eliminating their sequences from the genome. Through PGR, lamprey delete approximately 20% of their genome from all somatic cells, with these specific sequences being only …

Optimal Gateway Placement In Low-Cost Smart Cities, Oluwashina Madamori

Theses and Dissertations--Computer Science

Rapid urbanization burdens city infrastructure and creates the need for local governments to maximize the usage of resources to serve its citizens. Smart city projects aim to alleviate the urbanization problem by deploying a vast amount of Internet-of-things (IoT) devices to monitor and manage environmental conditions and infrastructure. However, smart city projects can be extremely expensive to deploy and manage partly due to the cost of providing Internet connectivity via 5G or WiFi to IoT devices. This thesis proposes the use of delay tolerant networks (DTNs) as a backbone for smart city communication; enabling developing communities to become smart cities …

Investigation Of Atmospheric Effects On Vapor Intrusion Processes Using Modelling Approaches, Elham Shirazi

Theses and Dissertations--Civil Engineering

Most people in the United States (US) spend considerable amount of time indoors—about 90% of their time as compared to outdoors, which makes the US population vulnerable to adverse health effects of indoor air contaminants. Volatile organic compound (VOC) concentrations are well-known to be higher in indoor air than outdoor air. One source of VOC concentrations in indoor air that has gained considerable attention in public health and environmental regulatory communities is vapor intrusion. Vapor intrusion is the process by which subsurface vapors enter indoor spaces from contaminated soil and groundwater. It has been documented to cause indoor air contamination …

Efficient Identification Of Function: A Comparison Of Different Implementers During Functional Analyses, Katelyn E. Nicklow

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

Functional analyses (FAs) are a common tool used in the assessment and treatment of severe problem behaviors and often occur in the context of clinical settings with unfamiliar, trained staff. Previous research suggests that inconsistent outcomes can emerge when caregivers with an existing history of seeing their child’s challenging behavior are trained to implement the assessment in place of clinical staff. The purpose of the current study was to expand on existing literature by comparing FA implemented by clinical staff and caregivers in the context of a clinical setting. Results demonstrate that efficient identification of function and differentiated rates of …

Johnny Appleseed: Citizenship Transmission Laws And A White Heteropatriarchal Property Right In Philandering, Sexual Exploitation, And Rape (The Whp) Or Johnny And The Whp, Blanche Cook

Law Faculty Scholarly Articles

Title 8, United States Code, Section 1409-one of this country's

citizenship transmission laws-creates a white heteropatriarchal property right

in philandering, sexual exploitation, and rape (the "WHP"). Section 1409

governs the transmission of citizenship from United States citizens to their

children, where the child is born abroad, outside of marriage, and one parent is a

citizen and the other is not. Section 1409, however, draws a distinct gender

distinction between women and men: An unwed female American citizen who

births a child outside the United States, fathered by a foreign man, automatically

transmits citizenship to her child. An unwed male American …

Speaking Their Truth: Black Women's Perspectives On Executive-Level Administration In Higher Education, Tanja N. Bibbs

Theses and Dissertations--Education Sciences

While Black women have etched a place for themselves as leaders within colleges and universities, few have advanced to the most senior levels of postsecondary administration and they remain underrepresented in those type of roles (Gamble & Turner, 2015; Jackson & Harris, 2007; West, 2015). Scholarly research has explored Black women’s experiences as institutional leaders (Davis & Maldonado, 2015; Smith & Crawford, 2007; Waring, 2003); yet the phenomenon of executive-level higher education administration, specifically as it relates to Black women’s perspectives, is not well known (Enke, 2014; Jean-Marie, Williams, & Sherman, 2009). Moreover, research that directs attention to Black women’s …

Development And Preliminary Evaluation Of An Integrated Individual Nozzle Direct Injection And Carrier Flow Rate Control System For Pesticide Applications, Joe D. Luck, Scott A. Shearer, Michael P. Sama

Biosystems and Agricultural Engineering Faculty Publications

Direct injection systems for agricultural spray applications continue to present challenges in terms of commercialization and adoption by end users. Such systems have typically suffered from lag time and mixing uniformity issues, which have outweighed the potential benefits of keeping chemical and carrier separate or reducing improper tank-mixed concentration by eliminating operator measurements. The proposed system sought to combine high-pressure direct nozzle injection with an automated variable-flow nozzle to improve chemical mixing and response times. The specific objectives were to: (1) integrate a high-pressure direct nozzle injection system with variable-flow carrier control into a prototype for testing, (2) assess the …

Conceptual Groundwater Remedial Alternatives At Coal Combustion Residuals Sites†, Herwig Goldemund, Jeffrey M. Ahrens

Coal Combustion and Gasification Products Journal Archive

Groundwater below many basins that have been used to store coal combustion residuals (CCRs) may have concentrations of certain inorganic constituents in excess of applicable regulatory standards. Given that many inorganic CCR constituents are also naturally occurring in the aquifer matrix, their detection may not always be indicative of a release from the CCR unit. Inorganics may be present at elevated levels in groundwater due to natural or background conditions, or due to changes to the aquifer geochemistry resulting from the presence of the CCR basin, which then mobilizes these naturally occurring constituents beneath the CCR unit. Care must be …

Phaselous Vulgaris Growth Under The Influence Of Manufactured Coal Ash Aggregates, Sangchul Hwang, Imiraily Hernandez, Isomar Latorre, Sahid Rosado

Coal Combustion and Gasification Products Journal Archive

Manufactured coal ash aggregates (MAs) are a 2:1 (w/w) solidified composite of fly and bottom ash. The current study assessed the feasibility of beneficial utilization of MAs as a subsoil substitute for open-pit restoration to phyto-viable land. A series of indoor and outdoor experiments examined Phaselous vulgaris growth under the influence of MAs in the soil environment. With the MAs layer below the topsoil, P. vulgaris showed enhanced growth with respect to shoot height, leaf number, and leaf chlorophyll intensity. Similar growth enhancement was observed when the MAs were mixed with topsoil or applied as a micronutrient source over the …

Effects Of Naltrexone On Alcohol And Nicotine Use In Female P Rats, Usman Z. Hamid, Sarah E. Maggio, Meredith A. Saunders, Kimberly Nixon, Mark A. Prendergast, Richard L. Bell, Michael T. Bardo

Posters-at-the-Capitol Presentations

The objective of the present study was to determine the effectiveness of the opioid antagonist naltrexone at reducing the consumption of EtOH and nicotine in female alcohol-preferring (P) rats. P rats have been selectively bred to have a genetic predisposition for alcohol abuse, which allows them to be used as an animal model of alcoholism. P rats readily self-administer i.v nicotine (Le et al., 2016), have EtOH consumption during adolescence that is similar to that seen in adulthood, and operantly respond for EtOH until they are impaired/intoxicated (Bell et al., 2006). Thus, P rats are a useful model for studying …

Berrycare: A Sustainable Community-Academia Nutrition Based Collaborative Program To Promote Well-Being In Older Adults, Abbey L. Moellering

Theses and Dissertations--Nutrition and Food Systems

With medical advancement and technology, generations are living longer. The process of aging is accompanied by development of chronic disease, reduced physical function, and increased risk of mortality. Older adults do not meet dietary requirements for fruits and vegetables due to lack of access, early satiety, socioeconomic factors, etc. Without proper attainment of fruit and vegetable recommendations, older adults are placed at risk of chronic disease. Interventions exist to help bridge the gap between older adult nutrition and currently established dietary guidelines. Built environments, such as community gardens, have received attentions in the public health arena as a successful way …

Exploring Mechanisms Of Persistent Cognitive Deficits In Mice With Transient Hyperhomocysteinemia, Reeya Khanal

Neuroscience Scholars Theses

Hyperhomocysteinemia (Hhcy) has been found in the elderly and is considered a risk factor for several neurological diseases, especially Alzheimer’s and Vascular Dementia. Previous studies have found an increase in Blood-Brain Barrier (BBB) leakage, glial activation, neuronal damage, and cognitive deficit with elevated levels of plasma homocysteine. Lowering homocysteine could be an easy and inexpensive way to reduce the risk of dementia. But it is still not known for sure if reducing plasma homocysteine levels can recover cognitive function. In our transient Hhcy model, 28 mice were given Hhcy inducing or nutritionally matched control diet for 8 weeks and then …

Fraud Detection Protocol For Web-Based Research Among Men Who Have Sex With Men: Development And Descriptive Evaluation, April M. Ballard, Trey Cardwell, April M. Young

Epidemiology and Environmental Health Faculty Publications

Background: Internet is becoming an increasingly common tool for survey research, particularly among “hidden” or vulnerable populations, such as men who have sex with men (MSM). Web-based research has many advantages for participants and researchers, but fraud can present a significant threat to data integrity.

Objective: The purpose of this analysis was to evaluate fraud detection strategies in a Web-based survey of young MSM and describe new protocols to improve fraud detection in Web-based survey research.

Methods: This study involved a cross-sectional Web-based survey that examined individual- and network-level risk factors for HIV transmission and substance use among young MSM …

Kentucky Water Resources Research Institute, University Of Kentucky: Annual Technical Report 2018, Kentucky Water Resources Research Institute, University Of Kentucky

KWRRI Annual Technical Reports (USGS’s 104b Grant Program)

In 2018, KWRRI launched a new website, https://www.research.uky.edu/kentucky-water-resources-research-institute, to better meet the needs of its stakeholders. KWRRI also established a repository for KWRRI’s reports, https://uknowledge.uky.edu/kwrri/. The repository includes historical KWRRI reports, annual symposium proceedings, technical reports, and the Water Distribution System Research Database. During the reporting period, KWRRI produced two editions of its semi-annual newsletter (Spring 2018 and Winter 2019). The newsletter provides updates, facilitates information sharing, and increases communication among those in the Kentucky water community. The 2019 Kentucky Water Resources Annual Symposium was held on March 25, 2019, in Lexington, Kentucky. The day-long symposium, attended by …