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Report On The First Year Of Operation Of Kentucky’S First Utility Wind Turbine, Lawrence E. Holloway, Sophia A. Hahn, Aron Patrick Aug 2025

Report On The First Year Of Operation Of Kentucky’S First Utility Wind Turbine, Lawrence E. Holloway, Sophia A. Hahn, Aron Patrick

Electrical and Computer Engineering Faculty Publications

This report examines the first year’s operational data from Kentucky’s first utility wind turbine, the 37 m hub-height 90-kilowatt NPS100C-27, operated by the PPL Corporation Research and Development at their Renewable Integration Research Facility in Mercer County, Kentucky. During that year, the turbine was available 95% of the time, spinning 85% of the time, and generating power 78% of the time, and had a net capacity factor of 11%. This report analyzes the turbine performance and uses the collected wind data to project the performance of an example turbine more typical of larger commercial turbines recently installed elsewhere in the …


Data For Services For Children Of All Abilities In Libraries (Scale) Project, Maria Cahill, Denice Adkins, Bobbie Sartin Long, Derek Thomas Myles Daskalakes, Caroline Gooden, Melissa Stormont, Alicia K. Long, Carol Russell Aug 2025

Data For Services For Children Of All Abilities In Libraries (Scale) Project, Maria Cahill, Denice Adkins, Bobbie Sartin Long, Derek Thomas Myles Daskalakes, Caroline Gooden, Melissa Stormont, Alicia K. Long, Carol Russell

Information Science Faculty Data

The University of Kentucky, in collaboration with the University of Missouri and Emporia State University, and in partnership with the Kentucky Department of Libraries and Archives, the State Library of Kansas, the State Library of Missouri, the Kansas State Department of Education, the Kentucky Department of Education, and the Kentucky Governor’s Office of Early Childhood, engaged in a four-year exploratory stage, multi-state, Research in Service to Practice project investigating the effectiveness of library services, practices, and behaviors effective for serving children with disabilities and/or developmental delays who span ages birth to 5-years. Aligned with the IMLS agency-level Promote Lifelong Learning …


Evaluation Of Real-World Evidence To Assess Health Outcomes Related To Deprescribing Medications In Older Adults, Kaleen N. Hayes, Joshua David Niznik, Danijela Gnjidic, Frank Moriarty, Nha Tran, Antoinette B. Coe, Andrew R. Zullo, Sirui Zhang, Matthew Alcusky, Dimitri Bennett, Sirpa Hartikainen, Marie Laure Laroche, Xiaojuan Li, Joshua K. Lin, Jennifer L. Lund, Maurizio Sessa, Shahar Shmuel, Caroline Sirois, Denis Talbot, Miia Tiihonen, Xuerong Wen, Mouna J. Sawan, Daniela C. Moga Aug 2025

Evaluation Of Real-World Evidence To Assess Health Outcomes Related To Deprescribing Medications In Older Adults, Kaleen N. Hayes, Joshua David Niznik, Danijela Gnjidic, Frank Moriarty, Nha Tran, Antoinette B. Coe, Andrew R. Zullo, Sirui Zhang, Matthew Alcusky, Dimitri Bennett, Sirpa Hartikainen, Marie Laure Laroche, Xiaojuan Li, Joshua K. Lin, Jennifer L. Lund, Maurizio Sessa, Shahar Shmuel, Caroline Sirois, Denis Talbot, Miia Tiihonen, Xuerong Wen, Mouna J. Sawan, Daniela C. Moga

Epidemiology and Environmental Health Faculty Publications

Observational studies using real-world data (RWD) can address gaps in knowledge on deprescribing medications but are subject to methodological issues. Limited data exist on the methods employed to use RWD to measure the effects of deprescribing. To describe methodological approaches used in observational studies of deprescribing medications in older adults, we conducted a systematic review in Medline for observational studies published in English (January 1, 2000, to September 14, 2023) that examined the health effects of medication deprescribing in older adults. We described study characteristics and methods, focusing on the operationalization of deprescribing as an exposure and potential time-related biases. …


Impact Of Manganese And Metal Mixtures In Blood, Hair, And Soil On Child Adaptive Behaviors In Southeast Side Chicago, Christine Kim, Timothy J. Hilbert, Kelly J. Brunst, Anthony A. Mangino, W. Jay Christian, Patrick J. Parsons, Christopher D. Palmer, Julio Landero, Susan Westneat, Ian Papautsky, Kim N. Dietrich, Erin N. Haynes Aug 2025

Impact Of Manganese And Metal Mixtures In Blood, Hair, And Soil On Child Adaptive Behaviors In Southeast Side Chicago, Christine Kim, Timothy J. Hilbert, Kelly J. Brunst, Anthony A. Mangino, W. Jay Christian, Patrick J. Parsons, Christopher D. Palmer, Julio Landero, Susan Westneat, Ian Papautsky, Kim N. Dietrich, Erin N. Haynes

Epidemiology and Environmental Health Faculty Publications

Background: Manganese (Mn) is essential in growth and development, yet higher levels of Mn are associated with deficits in neurodevelopment. Elevated air Mn was identified near Mn alloy processing facilities in Southeast Side Chicago resulting in community concern about child exposure and health. Methods: Blood, hair, and soil samples were collected and analyzed for multiple metals for children ages 7–17 years and a parent/primary caregiver completed surveys. We used generalized estimating equations to assess associations between metals and the Adaptive Behavior Assessment System 3rd Edition (ABAS-3) scores. Sensitivity analyses were conducted to determine effect modification by child sex on associations …


Guidance On Minimum Information Requirements (Mir) From Designing To Reporting Human Biomonitoring (Hbm), Maryam Zare Jeddi, Karen S. Galea, Jillian Ashley-Martin, Julianne Nassif, Tyler Pollock, Devika Poddalgoda, Konstantinos M. Kasiotis, Kyriaki Machera, Holger M. Koch, Marta Esteban López, Ming Kei Chung, Jihyon Kil, Kate Jones, Adrian Covaci, Yu Ait Bamai, Mariana F. Fernandez, Robert Pasanen Kase, Henriqueta Louro, Maria J. Silva, Tiina Santonen, Andromachi Katsonouri, Argelia Castaño, Lesliam Quirós-Alcalá, Elizabeth Ziying Lin, Krystal Pollitt, Ana Virgolino, Paul T.J. Scheepers, Lisa Jo Melnyk Aug 2025

Guidance On Minimum Information Requirements (Mir) From Designing To Reporting Human Biomonitoring (Hbm), Maryam Zare Jeddi, Karen S. Galea, Jillian Ashley-Martin, Julianne Nassif, Tyler Pollock, Devika Poddalgoda, Konstantinos M. Kasiotis, Kyriaki Machera, Holger M. Koch, Marta Esteban López, Ming Kei Chung, Jihyon Kil, Kate Jones, Adrian Covaci, Yu Ait Bamai, Mariana F. Fernandez, Robert Pasanen Kase, Henriqueta Louro, Maria J. Silva, Tiina Santonen, Andromachi Katsonouri, Argelia Castaño, Lesliam Quirós-Alcalá, Elizabeth Ziying Lin, Krystal Pollitt, Ana Virgolino, Paul T.J. Scheepers, Lisa Jo Melnyk

Epidemiology and Environmental Health Faculty Publications

Human biomonitoring (HBM) provides an integrated chemical exposures assessment considering all routes and sources of exposure. The accurate interpretation and comparability of biomarkers of exposure and effect depend on harmonized, quality-assured sampling, processing, and analysis. Currently, the lack of broadly accepted guidance on minimum information required for collecting and reporting HBM data, hinders comparability between studies. Furthermore, it prevents HBM from reaching its full potential as a reliable approach for assessing and managing the risks of human exposure to chemicals. The European Chapter of the International Society of Exposure Science HBM Working Group (ISES Europe HBM working group) has established …


Bike/Ped Data Collection And Model Calibration, Eirini Stavropoulou, Dionysios Tzamakos, Nikiforos Stamatiadis, Reginald Souleyrette, Teng Wang Aug 2025

Bike/Ped Data Collection And Model Calibration, Eirini Stavropoulou, Dionysios Tzamakos, Nikiforos Stamatiadis, Reginald Souleyrette, Teng Wang

Kentucky Transportation Center Research Report

Motivated by an uptick in pedestrian and bicycle traffic, as well as the inclusion of pedestrian and bicyclist weights in the Strategic Highway Investment Formula For Tomorrow, the Kentucky Transportation Cabinet (KYTC) has made significant investments in transportation facilities for nonmotorized users. Despite an intensified focus on the needs of nonmotorized users, KYTC has not yet established a formal program to track the number of people walking, biking, skateboarding, and using micromobility devices statewide. Based on a review of methods and technologies for counting nonmotorized users; analysis of counting programs established by local, state, and regional transportation agencies; and a …


Proto-Oncogene Hras Transcript Level And Overall Survival In Stages Ii And Iii Colorectal Cancer, Donghyun Kim, Saima Sharif, Juan Antonio Raygoza Garay, Avanish S. Bhakta, Patrick M. Boland, Michael J. Cavnar, Michelle L. Churchman, Hassan Hatoum, Lyen C. Huang, Joseph Kim, Richard Kim, Robert W. Lentz, Sarbajit Mukherjee, Mary T. O'Donnell, Benjamin Quartey, Matthew J. Reilley, Robert J. Rounbehler, Bodour Salhia, Bryan P. Schneider, Carlos H. Chan Aug 2025

Proto-Oncogene Hras Transcript Level And Overall Survival In Stages Ii And Iii Colorectal Cancer, Donghyun Kim, Saima Sharif, Juan Antonio Raygoza Garay, Avanish S. Bhakta, Patrick M. Boland, Michael J. Cavnar, Michelle L. Churchman, Hassan Hatoum, Lyen C. Huang, Joseph Kim, Richard Kim, Robert W. Lentz, Sarbajit Mukherjee, Mary T. O'Donnell, Benjamin Quartey, Matthew J. Reilley, Robert J. Rounbehler, Bodour Salhia, Bryan P. Schneider, Carlos H. Chan

Surgery Faculty Publications

Background: Mutational landscape is prognostic in colorectal cancer (CRC). Rat sarcoma (RAS) oncogenes, such as KRAS and NRAS, with driver mutations, portend poor survival outcomes, whereas pathologic mutations in HRAS are extremely rare, and their prognostic value remains uncertain. Methods: This retrospective study analyzed the Oncology Research Information Exchange Network (ORIEN) alliance tumor RNA-Seq data in Stages II and III CRC to investigate the association between RAS gene expression and survival outcomes. Results: High transcript levels of HRAS were associated with superior overall survival (OS). The high HRAS-associated OS benefit was most pronounced in patients with right-sided primary expressing low …


New Synthetic Resorbable Mesh For Open Ventral Hernia Repair, J. Scott Scott Roth, Bruce Ramshaw, Yohann Renard, G. Passot, Frederik Berrevoet, Katie Bayliss, Marion Blanc, Charles Cain, Matthew Goldblatt Jul 2025

New Synthetic Resorbable Mesh For Open Ventral Hernia Repair, J. Scott Scott Roth, Bruce Ramshaw, Yohann Renard, G. Passot, Frederik Berrevoet, Katie Bayliss, Marion Blanc, Charles Cain, Matthew Goldblatt

Surgery Faculty Publications

Introduction Ventral hernia repair is among the most commonly performed general surgical procedures, during which meshes are often used to provide further support to weakened or damaged tissue surrounding the hernia repair site. Slowly resorbable synthetic meshes have recently emerged as a valid choice, as confirmed by published clinical evidence on launched meshes in the repair of ventral hernias showing satisfactory results. This study was designed to assess the performance and safety of a newly developed slowly fully resorbable self-gripping synthetic mesh in patients undergoing ventral hernia repair through open surgery in clean and clean-contaminated fields. Methods and analysis This …


The International Soft Tissue Sarcoma Consortium, Gianni Bisogno, Monika Sparber-Sauer, David Rodeberg, Johannes H.M. Merks, Ewa Koscielniak, Suzanne L. Wolden, Gian Luca De Salvo, Paola Del Bianco, Wei Xue, Martin Ebinger, Christian Vokuhl, Rajkumar Venkatramani, Samuel L. Volchenboum, Brian Furner, Veronique Minard Colin, Douglas S. Hawkins Jul 2025

The International Soft Tissue Sarcoma Consortium, Gianni Bisogno, Monika Sparber-Sauer, David Rodeberg, Johannes H.M. Merks, Ewa Koscielniak, Suzanne L. Wolden, Gian Luca De Salvo, Paola Del Bianco, Wei Xue, Martin Ebinger, Christian Vokuhl, Rajkumar Venkatramani, Samuel L. Volchenboum, Brian Furner, Veronique Minard Colin, Douglas S. Hawkins

Surgery Faculty Publications

Background: The International Soft Tissue Sarcoma Consortium (INSTRuCT) was established in 2017 to enhance international collaboration. This study describes the characteristics of rhabdomyosarcoma (RMS) patients in the INSTRuCT database and examines differences across contributing groups. Methods: INSTRuCT includes data Children’s Oncology Group (COG), Cooperative Weichteilsarkom Studiengruppe (CWS), and European Paediatric Soft Tissue Sarcoma Study Group (EpSSG) along with prior studies from Malignant Mesenchymal Tumour Committee (MMT) and Italian Soft Tissue Sarcoma Committee (STSC). Data standardization was supported by the University of Chicago’s Pediatric Cancer Data Commons. Pseudonymized patient-level data from clinical trials were harmonized. Differences across groups were assessed using …


The Kentucky Microbiome Dataset, Rachel L. Washburn, Douglas C. Curl Jul 2025

The Kentucky Microbiome Dataset, Rachel L. Washburn, Douglas C. Curl

Research Data--KGS

The Kentucky Microbiome Dataset is a continuously updated geolocated dataset which describes the distribution and diversity of microorganisms across the Commonwealth of Kentucky. Each geolocated point represents a location reported in the peer-reviewed literature where microorganisms were sampled from soil, water, geologic substrates, or clinical settings. Environmental studies include only non-host-associated, non-clinical microorganisms sampled from natural environments. Clinical studies are mapped separately to highlight locations where investigations into host-associated or human health-related microbes have occurred.

For each location, associated metadata include study information, taxonomic classifications, sample type, sampling method, latitude and longitude, sampling date, publication reference, and a direct link …


Receptor-Mediated Spion Labeling Of Cd4+ T Cells For Longitudinal Mri Tracking Of Distribution Following Systemic Injection In Mouse, Yu Ping, Songyue Han, Brock Howerton, Francesc Marti, Jake Weeks, Roberto Gedaly, Reuben Adatorwovor, Fanny Chapelin Jul 2025

Receptor-Mediated Spion Labeling Of Cd4+ T Cells For Longitudinal Mri Tracking Of Distribution Following Systemic Injection In Mouse, Yu Ping, Songyue Han, Brock Howerton, Francesc Marti, Jake Weeks, Roberto Gedaly, Reuben Adatorwovor, Fanny Chapelin

Surgery Faculty Publications

Tracking T cells in vivo using MRI is a major challenge due to the difficulty of labeling these non-phagocytic cells with a sufficient contrast agent to generate a detectable signal change. In this study, we explored CD4-Superparamagnetic iron oxide nanoparticles (SPION), which is commonly used in magnetic cell sorting, as a potential receptor-mediated, specific CD4+ T cell MRI labeling agent. We optimized the labeling protocol for maximal CD4+ cell labeling and viability. Cell health was confirmed with trypan blue assay, and labeling efficacy was confirmed with Prussian blue staining, transmission electron microscopy, and MRI of labeled cell pellets. Key cell …


Effects Of The Communities That Heal Intervention On Initiation, Retention, And Linkage To Medications For Opioid Use Disorder (Moud), Jennifer L Brown, Marc R Larochelle, Laura C Fanucchi, Deirdre C Calvert, Aimee N C Campbell, Redonna K Chandler, Daniel J Feaster, Lashawn M Glasgow, Erin B Gibson, Janae Holloway, Michelle R Lofwall, Aimee Mack, Nicole Mack, Edward V Nunes, Jeffery C Talbert, Sylvia Tan, Nathan Vandergrift, Jennifer Villani, Kat Asman, Hermik Babakhanlou-Chase, Sarah M Bagley, Tracy A Battaglia, Derek Blevins, Carly Bridden, Debbie M Cheng, Mia Christopher, Lindsay W Cogan, Chinazo O Cunningham Jul 2025

Effects Of The Communities That Heal Intervention On Initiation, Retention, And Linkage To Medications For Opioid Use Disorder (Moud), Jennifer L Brown, Marc R Larochelle, Laura C Fanucchi, Deirdre C Calvert, Aimee N C Campbell, Redonna K Chandler, Daniel J Feaster, Lashawn M Glasgow, Erin B Gibson, Janae Holloway, Michelle R Lofwall, Aimee Mack, Nicole Mack, Edward V Nunes, Jeffery C Talbert, Sylvia Tan, Nathan Vandergrift, Jennifer Villani, Kat Asman, Hermik Babakhanlou-Chase, Sarah M Bagley, Tracy A Battaglia, Derek Blevins, Carly Bridden, Debbie M Cheng, Mia Christopher, Lindsay W Cogan, Chinazo O Cunningham

Biostatistics Faculty Publications

Medications for opioid use disorder (MOUD) can reduce opioid use and overdose deaths. This study examined whether the Communities That HEAL (CTH) intervention increased MOUD initiation, retention, and linkage. The HEALing Communities Study was a multi-site, 2-arm, parallel, community-level, cluster-randomized, unblinded, wait-list controlled trial conducted in 67 communities (n = 34 intervention, n = 33 control). Using Prescription Drug Monitoring Programs and Medicaid claims data, we compared mean community-level rates of MOUD outcomes during the 1-year comparison period (July 2021-June 2022) for: (a) MOUD receipt at least once; (b) continuous MOUD receipt for 180 days; and (c) MOUD linkage within …


Map Of The Thickness Of Ordovician Shales Across The Kentucky-Tennessee Mineral District (Ktmd), John B. Hickman, Alex M. Washburn, Georgina Lukoczki Jul 2025

Map Of The Thickness Of Ordovician Shales Across The Kentucky-Tennessee Mineral District (Ktmd), John B. Hickman, Alex M. Washburn, Georgina Lukoczki

Research Data--KGS

The deposits of critical minerals have been found in metalliferous shales. To aid in critical mineral assessments of the Ordovician Shales in the Kentucky-Tennessee Mineral District (KTMD), this research project produced a map (digital GIS dataset) of the thickness (isopach) of the combined Upper Ordovician shale interval across the region. The subsurface input data are from oil/gas well records and exploratory mineral core. Well and core records for the KTMD were acquired from the state surveys of Tennessee and Kentucky. Along with the GIS files, a summary table of the 594 well and core data points used to produce this …


Balancing Infrastructure Demands: Analysis Of Materials Pricing And Supply, Bethany Paris, Ying Li, Steve Waddle, Bryan Gibson Jul 2025

Balancing Infrastructure Demands: Analysis Of Materials Pricing And Supply, Bethany Paris, Ying Li, Steve Waddle, Bryan Gibson

Kentucky Transportation Center Research Report

The Kentucky Transportation Cabinet (KYTC) lets around 700 contracts year valued at over $1 billion. One of KYTC’s foremost goals is to deliver projects on time and on budget. However, over the past five years achieving these twin goals has grown in difficulty due to material shortages, widespread inflation, supply chain disruptions, and the tight labor market triggered by the COVID-19 pandemic. Although material shortages have abated and supply chain disruptions have eased, instability is seemingly a permanent feature of the national and global economies. As such, Cabinet decision makers need reliable tools that can be used to understand historical …


Adverse Birth Outcomes Associated With Heat Stress And Wildfire Smoke Exposure During Preconception And Pregnancy, Roxana Khalili, Yisi Liu, Yan Xu, Karl O’Sharkey, Nathan Pavlovic, Crystal Mcclure, Fred Lurmann, Tingyu Yang, Xinci Chen, Mario Vigil, Brendan Grubbs, Layla Al Marayati, Deborah Lerner, Nathana Lurvey, Carmen J. Marsit, Jill Johnston, Theresa M. Bastain, Carrie V. Breton, Shohreh F. Farzan, Rima Habre Jul 2025

Adverse Birth Outcomes Associated With Heat Stress And Wildfire Smoke Exposure During Preconception And Pregnancy, Roxana Khalili, Yisi Liu, Yan Xu, Karl O’Sharkey, Nathan Pavlovic, Crystal Mcclure, Fred Lurmann, Tingyu Yang, Xinci Chen, Mario Vigil, Brendan Grubbs, Layla Al Marayati, Deborah Lerner, Nathana Lurvey, Carmen J. Marsit, Jill Johnston, Theresa M. Bastain, Carrie V. Breton, Shohreh F. Farzan, Rima Habre

Epidemiology and Environmental Health Faculty Publications

We investigated associations between preconception and prenatal heat stress and wildfire (WF) smoke exposures on adverse birth outcomes and whether neighborhood climate vulnerability is an effect modifier in the Maternal And Developmental Risks from Environmental and Social stressors cohort (N = 713). Generalized linear models were fit to test the association between exposures and small-for-gestational-age (SGA), low birthweight (LBW), and Fenton growth z-score outcomes, adjusting for confounders. Living in a high climate vulnerability index neighborhood was tested as an effect modifier. During preconception, increases in heat stress and WF measures were associated with higher odds of SGA. Living in the …


Enhanced Pavement Project Prioritization, Bryan Gibson, Jon Wilcoxson, Gayle Marks Jul 2025

Enhanced Pavement Project Prioritization, Bryan Gibson, Jon Wilcoxson, Gayle Marks

Kentucky Transportation Center Research Report

The Kentucky Transportation Cabinet (KYTC) is responsible for inspecting, maintaining, and improving 27,000 centerline miles of pavement. Given the vastness of the state’s transportation network, KYTC needs a robust method for prioritizing pavement preservation projects. The Cabinet has relied on pavement condition ratings, data collected using Laser Crack Measurement Systems, and input from district-level staff to prioritize these types of projects. But this approach overlooks information that should be considered, such as factors related to safety, mobility, and geographic context. To resolve these shortcomings, Kentucky Transportation Center (KTC) researchers worked with KYTC subject-matter experts to develop the Enhanced Pavement Prioritization …


Thickness Of Devonian Shale, Kentucky-Tennessee Mineral District (Ktmd), John B. Hickman, Alex M. Washburn, Georgina Lukoczki Jul 2025

Thickness Of Devonian Shale, Kentucky-Tennessee Mineral District (Ktmd), John B. Hickman, Alex M. Washburn, Georgina Lukoczki

Research Data--KGS

The deposits of critical minerals have been found in metalliferous shales. To aid in critical mineral assessments of the Devonian Shales in the Kentucky-Tennessee Mineral District (KTMD), this research project produced a map (digital GIS dataset) of the thickness (isopach) of the combined New Albany Shale/Chattanooga Shale/Ohio Shale interval across the region. The subsurface input data are from oil/gas well records and exploratory mineral core. Well and core records for the KTMD were acquired from the state surveys of Tennessee and Kentucky. Along with the GIS files, a summary table of the 6,607 well and core data points used to …


Mines Of The Illinois-Kentucky Fluorspar District, Paul Puckett, Emily Morris, Georgina Lukoczki Jul 2025

Mines Of The Illinois-Kentucky Fluorspar District, Paul Puckett, Emily Morris, Georgina Lukoczki

Map and Chart--KGS

This map presents a unified compilation of mining and mineral resource information for the Illinois-Kentucky Fluorspar District (IKFD), integrating two previously published maps: Denny et al. (2020) for the Illinois portion and Anderson and Sparks (2012) for the Kentucky portion. While the Illinois side remains unchanged, the Kentucky side has been updated using newly compiled data from the Kentucky Geological Survey’s Kentucky Mineral Resources Information map service (https://kgs.uky.edu/KYMineral/). This composite map offers an improved and more comprehensive view of the IKFD, highlighting mineral occurrences, historical mining activity, and structural features of the district.


Structure On The Top Of Knox Group, Kentucky-Tennessee Mineral District (Ktmd), John B. Hickman Jul 2025

Structure On The Top Of Knox Group, Kentucky-Tennessee Mineral District (Ktmd), John B. Hickman

Research Data--KGS

The deposits of critical minerals within the Kentucky-Tennessee Mineral District (KTMD) are hosted within the Late Cambrian to Early Ordovician carbonate rocks of the Knox Group. To aid in critical mineral assessments of the region, this research project produced a map (digital GIS dataset) of the subsurface structure of the top of the Knox Group: the Knox Unconformity surface. All the input data is from oil/gas well records and exploratory mineral core records because these rocks are not exposed within the study area. Well and core records for the KTMD were acquired from the state surveys of Tennessee and Kentucky …


Who Reconstitutes The Chemotherapy? The Educational And Practice Needs Of Oncology Pharmacists In West Africa: A Call For Multidisciplinary Team Approach In Oncology Care., Runcie C.W. Chidebe, Ramatu M. Alabelewe, Krishna Prasad Sapkota, Darlingtina K. Esiaka, Candidus C. Nwakasi, Gloria C. Okwu, Jacinta Emejulu, Adamu A. Umar, Ndifreke Okwuegbunam, Funsho David, Toyosi Adepoju, Agha A. Agha, Ejike S. Ugwu, Simeon C. Aruah, Richard Mshelia, Rob Duncombe, Noel N. Wannang, Peace C. Babalola, R. Donald Harvey, Cindy O'Bryant, Folakemi T. Odedina Jul 2025

Who Reconstitutes The Chemotherapy? The Educational And Practice Needs Of Oncology Pharmacists In West Africa: A Call For Multidisciplinary Team Approach In Oncology Care., Runcie C.W. Chidebe, Ramatu M. Alabelewe, Krishna Prasad Sapkota, Darlingtina K. Esiaka, Candidus C. Nwakasi, Gloria C. Okwu, Jacinta Emejulu, Adamu A. Umar, Ndifreke Okwuegbunam, Funsho David, Toyosi Adepoju, Agha A. Agha, Ejike S. Ugwu, Simeon C. Aruah, Richard Mshelia, Rob Duncombe, Noel N. Wannang, Peace C. Babalola, R. Donald Harvey, Cindy O'Bryant, Folakemi T. Odedina

Behavioral Science Faculty Publications

PURPOSE: Oncology pharmacists (OPs) play a crucial role in cancer care, treatment, survivorship, and multidisciplinary teams (MDTs). OPs have specialized training in designing, administering, monitoring, and modifying oncology chemotherapy; managing adverse events; and evaluating clinical trials and investigational drugs. Yet, the state of OP has remained largely unknown in the clinical oncology workforce of the West African region. Therefore, this study aimed to understand who reconstitutes chemotherapy and to explain the OP educational and practice needs, challenges, and solutions in Nigeria.

MATERIALS AND METHODS: Using a concurrent embedded mixed method design, 35 OPs completed a questionnaire, and 12 others responded …


Genetically Proxied Blood Pressure, Vascular Brain Injury, And Alzheimer's Disease Pathology, Iyas Daghlas, Michelle R. Caunca, Lincoln M.P. Shade, Malik Nassan, Kristine Yaffe, David W. Fardo, Dipender Gill Jul 2025

Genetically Proxied Blood Pressure, Vascular Brain Injury, And Alzheimer's Disease Pathology, Iyas Daghlas, Michelle R. Caunca, Lincoln M.P. Shade, Malik Nassan, Kristine Yaffe, David W. Fardo, Dipender Gill

Biostatistics Faculty Publications

INTRODUCTION: Lower blood pressure (BP) is linked to reduced dementia risk, though it is uncertain whether this benefit stems solely from mitigating vascular brain injury (VBI) or also extends to directly influencing Alzheimer's disease (AD) pathology. We leveraged Mendelian randomization (MR) to assess whether lifelong lower BP is causally associated with neuropathological correlates of VBI and AD. METHODS: We identified genetic proxies for systolic and diastolic BP (n = 1,028,980) and applied them in MR analyses of post mortem neuropathological measures of VBI and AD (n = 6363–7786). RESULTS: Genetically proxied lower systolic BP associated with reduced risk of all …


Step By Step, Patrick M. Filanowski, Jeremy A. Steeves, Emily Slade Jul 2025

Step By Step, Patrick M. Filanowski, Jeremy A. Steeves, Emily Slade

Biostatistics Faculty Publications

Background/Objectives: Although public health organizations encourage family walking, no studies have examined children’s physical activity and enjoyment during outdoor parent–child walks. This study addresses those gaps by examining children’s moderate-to-vigorous physical activity (MVPA) and enjoyment during outdoor walks with their parents, along with parental barriers and their relationship with parent’s self-efficacy and co-activity minutes. Methods: Fifty parent–child dyads (children aged 6–12 years) completed 10 min, self-paced outdoor walks while wearing waist-worn ActiGraph monitors. Parents reported perceived barriers to walking outdoors with their child and self-efficacy for supporting their child’s daily physical activity. Results: Children reported high enjoyment (mean = 5.1 …


At The Nexus Between Epigenetics And Senescence, Toby L. Chambers, Jaden Wells, Pieter Jan Koopmans, Francielly Morena, Zain B. Malik, Nicholas P. Greene, Antonio Filareto, Michael Franti, Patrizia Sini, Harald Weinstabl, Robert T. Brooke, Milda Milčiūtė, Juozas Gordevičius, Steve Horvath, Yuan Wen, Cory M. Dungan, Kevin A. Murach Jul 2025

At The Nexus Between Epigenetics And Senescence, Toby L. Chambers, Jaden Wells, Pieter Jan Koopmans, Francielly Morena, Zain B. Malik, Nicholas P. Greene, Antonio Filareto, Michael Franti, Patrizia Sini, Harald Weinstabl, Robert T. Brooke, Milda Milčiūtė, Juozas Gordevičius, Steve Horvath, Yuan Wen, Cory M. Dungan, Kevin A. Murach

Physiology Faculty Publications

Senescent cells emerge with aging and injury. The contribution of senescent cells to DNA methylation age (DNAmAGE) in vivo is uncertain. Furthermore, stem cell therapy can mediate “rejuvenation”, but how tissue regeneration controlled by resident stem cells affects whole tissue DNAmAGE is unclear. We assessed DNAmAGE with or without senolytics (BI01) in aged male mice (24–25 months) 35 days following muscle healing (BaCl2-induced regeneration versus non-injured). Young injured mice (5–6 months) without senolytics were comparators. DNAmAGE was decelerated by up to 68% after injury in aged muscle. DNAmAGE was modestly but further significantly decelerated by injury recovery with …


Increasing Flora Diversity In Grassland Swards, R J. Haggar, D Jones Jun 2025

Increasing Flora Diversity In Grassland Swards, R J. Haggar, D Jones

IGC Proceedings (1977-2023)

Europe's farmers are being encouraged to take land out of agriculture in order to reduce surplus cereal production. There is therefore, increasing scope for creating new species-rich swards, although guidelines for this purpose are lacking. Several reasons are advanced for encouraging species diver­sity and conservation, including recreational, ethical, education and resource utilisation. As leisure time increases, so public interest in conservation matters increases. Scientifically, there is a need to preserve genetic diversity and to understand the com­plex plant and animal relationship leading to a rich and varied community. This paper describes two experiments aimed at achieving a . highly diverse …


Multiple Of The Intermountain Region, Forest Service, United States Department Of Agriculture, J S. Tixier, A H. Winward Jun 2025

Multiple Of The Intermountain Region, Forest Service, United States Department Of Agriculture, J S. Tixier, A H. Winward

IGC Proceedings (1977-2023)

Initial custodians of the National Forests of the United States were primarily concerned about protecting what were perceived as deteriorating timber stands and watersheds. Con­siderable progress was made in correcting these problems in the first half of this Century. As the population of the United States grew, more people became interested in management of all resources on these public lands. Forest Officers gradually became stewards managing a broad array of lands and resources for which there were often conflicting interests and uses. A primary use of National Forests in the Western United States has been livestock grazing. Here, animals are …


Glacial Erosion And History Of Inglefield Land, Northwestern Greenland, Caleb K. Walcott-George, Allie Balter-Kennedy, Jason P. Briner, Joerg M. Schaefer, Nicolás E. Young Jun 2025

Glacial Erosion And History Of Inglefield Land, Northwestern Greenland, Caleb K. Walcott-George, Allie Balter-Kennedy, Jason P. Briner, Joerg M. Schaefer, Nicolás E. Young

Earth and Environmental Sciences Faculty Publications

We used mapping of bedrock lithology, bedrock fractures, and lake density in Inglefield Land, northwestern Greenland, combined with cosmogenic nuclide (10Be and 26Al) measurements in bedrock surfaces, to investigate glacial erosion and the ice sheet history of the northwestern Greenland Ice Sheet. The pattern of eroded versus weathered bedrock surfaces and other glacial erosion indicators reveal temporally and spatially varying erosion under cold- and warm-based ice. All of the bedrock surfaces that we measured in Inglefield Land contain cosmogenic nuclide inheritance with apparent 10Be ages ranging from 24.9 ± 0.5 to 215.8 ± 7.4 ka. The …


Sisyphus And The Digital Library: Keep Rolling That Boulder Up The Hill (Careful, It's Heavy), Ruth E. Bryan, Sarah Dorpinghaus, Megan M. Mummey Jun 2025

Sisyphus And The Digital Library: Keep Rolling That Boulder Up The Hill (Careful, It's Heavy), Ruth E. Bryan, Sarah Dorpinghaus, Megan M. Mummey

Library Presentations

Oftentimes, archivists and programmers feel like Sisyphus of Greek myth, continually rolling our boulder, the digital library, up the hill of stakeholder expectations. Since 1998, the University of Kentucky Libraries has provided online access to digital and digitized archival content through ExploreUK.uky.edu and other sites. Like many other institutions, UK Libraries has faced technological, organizational, and communication challenges in this endeavor. This presentation explores how UK Libraries responded to these challenges by expanding the decision-making team, after years of unclear responsibility and ownership, to reinvigorate internal interest and investment in the local digital library system and workflows.


The Rhetoric Of Responsibilization: A Rhetorical Analysis Of Pre-Exposure Prophylaxis Campaigns For Hiv Prevention, Catherine M. Pabalate Jun 2025

The Rhetoric Of Responsibilization: A Rhetorical Analysis Of Pre-Exposure Prophylaxis Campaigns For Hiv Prevention, Catherine M. Pabalate

Kentucky Undergraduate Journal for the Health Humanities

Responsibilization refers to the process by which patients are made accountable for their health and wellbeing, which is determined by their habits and behaviors. Though responsibilization affords greater agency to patients, it can also result in anxiety and guilt when the patient appears "deviant" or "noncompliant." Because sexual behavior is attributed to the causality of HIV/AIDS, patients’ sexual patterns and choices are included within their medical decision-making. This rhetorical analysis focuses on pharmaceutical campaigns and commercials for pre-exposure prophylaxis (PrEP), which were released between 2012 and 2024 and are targeted towards patients at-risk for HIV/AIDS. Findings suggest that specific rhetorical …


How To Gender Include, Stephen Krueger Jun 2025

How To Gender Include, Stephen Krueger

Library Faculty and Staff Publications

Gender inclusion is not an optional part of library work—at least, it isn’t if we want all those “Libraries Are For Everyone” signs to be true. And yet, the reality is that many libraries fail the most basic aspects of gender inclusion for patrons, employees, or both. Even in libraries where Trans 101 trainings do occur and are well received, or where the baseline of knowledge among employees is relatively high, the question remains: What now?

This article intends to answer that question. Very broadly speaking, gender inclusion work in libraries means sustained action to ensure that some patrons and …


From Disruption To Recovery: Charter School Performance During And After The Covid-19 Pandemic, Adam Kho, Shelby Smith, Ron Zimmer Jun 2025

From Disruption To Recovery: Charter School Performance During And After The Covid-19 Pandemic, Adam Kho, Shelby Smith, Ron Zimmer

Public Policy and Administration Faculty Publications

In recent decades, an increasing number of students have pursued alternative educational options, including charter schools, as school choice has continued to expand. This trend was accelerated by the COVID-19 pandemic. While it is well established that students experienced widespread learning loss during the pandemic, it remains unclear whether the extent of that loss or the pace of recovery has differed between charter and traditional public schools (TPS). In the current study, we examine the effects of Tennessee charter schools on student achievement during and after the pandemic. Using student-level data from 2017-18 to 2022-23, we estimate the charter school …