Digital Commons Network^™

Association Between Opioid-Benzodiazepine Trajectories And Injurious Fall Risk Among Us Medicare Beneficiaries., Grace Hsin-Min Wang, Juan M. Hincapie-Castillo, Walid F. Gellad, Bobby L. Jones, Ronald I. Shorr, Seonkyeong Yang, Debbie L. Wilson, Jeannie K. Lee, Gary M. Reisfield, Chian K. Kwoh, Chris Delcher, Khoa A. Nguyen, Christopher A. Harle, Zachary A. Marcum, Wei-Hsuan Lo-Ciganic

Pharmacy Practice and Science Faculty Publications

Background/Objectives: Concurrent opioid (OPI) and benzodiazepine (BZD) use may exacerbate injurious fall risk (e.g., falls and fractures) compared to no use or use alone. Yet, patients may need concurrent OPI-BZD use for co-occurring conditions (e.g., pain and anxiety). Therefore, we examined the association between longitudinal OPI-BZD dosing patterns and subsequent injurious fall risk. Methods: We conducted a retrospective cohort study including non-cancer fee-for-service Medicare beneficiaries initiating OPI and/or BZD in 2016-2018. We identified OPI-BZD use patterns during the 3 months following OPI and/or BZD initiation (i.e., trajectory period) using group-based multi-trajectory models. We estimated the time to first injurious falls …

Assessing The Feasibility Of A Multimodal Liquid Biopsy For The Diagnosis Of Hpv-Associated Oropharyngeal Squamous Cell Carcinoma., James S. Lewis, Saskia Naegele, Vasileios Efthymiou, Mitra Mehrad, Kim A. Ely, Tim Waterboer, Krystle A. Lang Kuhs, Seth J. Davis, Kelsey Richard, Dipon Das, Daniel L. Faden

Markey Cancer Center Faculty Publications

OBJECTIVES: In this feasibility study, we explored the combined use of circulating tumor human papillomavirus (HPV) DNA (ctHPVDNA) and HPV serology as diagnostic tests for HPV-associated oropharyngeal squamous cell carcinoma (OPSCC).

METHODS: Among patients with research-banked serum or plasma at diagnosis, IgG antibodies to oncoproteins from HPV types 16, 18, 31, 33, 35, 45, 52, and 58 were detected with multiplex serology. Positivity for HPV 16 was defined based on detection of combinations of anti-E6, E1, E2, and E7 and for other high-risk types on detection of anti-E6 and anti-E7. Circulating tumor HPV DNA was detected by custom digital droplet …

Insights Into The Influence Of Income Variability On Cardiovascular Risk In Non-Elderly Adults With Type 2 Diabetes, Ketrell Mcwhorter

UK CARES Faculty Publications

No abstract provided.

Small Island Risks: Research Reflections For Disaster Anthropologists And Climate Ethnographers, Crystal A. Felima

UK CARES Faculty Publications

Disasters and climate-related events, including tropical storms, droughts, coastal erosion, and ocean acidification, threaten small island nations. Given the urgency of reducing disaster risks and the effects of climate change on vulnerable populations, this reflection essay pursues three objectives. First, it highlights the role of anthropology, ethnography, and multi-sited research in exploring disaster impacts, climate crises, and public policy in island communities. It then highlights national planning and inter-regional activities to build awareness of various risk reduction efforts by island nations and multi-governmental organizations. This article concludes with discussion prompts to engage researchers, scholars, students, and practitioners studying and working …

Wastewater Surveillance For Xylazine In Kentucky, Chris Delcher, Dana Quesinberry, Soroosh Torabi, Scott Berry, James W. Keck, Abhya Rani, Bikram Subedi

UK CARES Faculty Publications

Introduction: In the U.S., xylazine, the veterinary non-opioid sedative, has emerged as a major threat to people who use illicitly manufactured fentanyl and other drugs. The aim of this study was to compare wastewater detection of xylazine with other public health and safety surveillance data from 2019 to 2023 in Kentucky.

Methods: Wastewater samples from 5 rest areas, 2 truck weigh stations, and 4 wastewater treat- ment plants were tested for xylazine. Wastewater xylazine positivity rates were compared with xyla- zine-positive submission rates from the National Forensic Laboratory Information System and Kentucky’s fatal overdoses in 6-month periods (Period 1=January−June; Period …

A Guide To Successful Management Of Collaborative Partnerships In Quantitative Research: An Illustration Of The Science Of Team Science., Alyssa Platt, Tracy Truong, Mary Boulos, Nichole E Carlson, Manisha Desai, Monica M Elam, Emily Slade, Alexandra L Hanlon, Jillian H Hurst, Maren K Olsen, Laila M Poisson, Lacey Rende, Gina-Maria Pomann

Biostatistics Faculty Publications

Data-intensive research continues to expand with the goal of improving healthcare delivery, clinical decision-making, and patient outcomes. Quantitative scientists, such as biostatisticians, epidemiologists, and informaticists, are tasked with turning data into health knowledge. In academic health centres, quantitative scientists are critical to the missions of biomedical discovery and improvement of health. Many academic health centres have developed centralized Quantitative Science Units which foster dual goals of professional development of quantitative scientists and producing high quality, reproducible domain research. Such units then develop teams of quantitative scientists who can collaborate with researchers. However, existing literature does not provide guidance on how …

Active And Retroactive Digital Newspaper Preservation, Andrew Mcdonnell

Library Faculty and Staff Publications

The University of Kentucky Libraries’ (UKL) long-running efforts to document and provide access to the state’s history via newspaper preservation have necessarily evolved over the last 80 years. As news formats and preservation technologies have changed, particularly in relation to born-digital media, the libraries’ efforts have had to keep pace. The race to preserve these materials before they disappear or are locked away on media inaccessible to modern computers is not always chronologically linear, though. Digital archivists and librarians must sometimes straddle multiple generations of technology to successfully migrate, capture, and otherwise preserve digital publications, and there is no single …

Best Practices For Maintenance Of Traffic On Interstate Pavement Rehabilitation Projects, Catherine Keathley, Ryan Griffith, Rachel Catchings

Kentucky Transportation Center Research Report

Across the United States, aging roadway infrastructure has led state departments of transportation (DOTs) to increase their focus on pavement rehabilitation projects. These projects upgrade existing infrastructure to meet the needs of current levels of vehicle use. On interstate rehabilitation projects, maintenance of traffic (MOT) is an especially important consideration. Having a good MOT plan for completing construction work is critical for maintaining facility capacity while ensuring the safety of the traveling public and roadway construction staff. This study explores on behalf of the Kentucky Transportation Cabinet (KYTC) best practices for MOT on interstate pavement rehabilitation projects. Based on a …

Accommodating Innovative Uses Of Public Right Of Way, Travis Thompson, David Moses, Candice Wallace, Pam Clay-Young, Arlen Sandlin

Kentucky Transportation Center Research Report

State departments of transportation (DOTs) are embracing the use of clean energy and connectivity (CEC) applications along publicly owned right of way (ROW). Applications such as wind and solar power installations, broadband lines, small cell wireless equipment, electric vehicle charging stations, and technologies related to connected and automated vehicles (CAVs) hold considerable promise for conferring environmental benefits, energy savings, and generating much-needed revenue for DOTs. This report explores innovative uses of state-owned ROW that the Kentucky Transportation Cabinet (KYTC) could implement. Although Kentucky may not be currently situated for all clean energy applications, opportunities in solar do currently exist and …

Limbic-Predominant Age-Related Tdp-43 Encephalopathy (Late-Nc): Co-Pathologies And Genetic Risk Factors Provide Clues About Pathogenesis, Peter T. Nelson, David Fardo, Xian Wu, Khine Zin Aung, Matthew D. Cykowski, Yuriko Katsumata

Neurology Faculty Publications

Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is detectable at autopsy in more than one- third of people beyond age 85 years and is robustly associated with dementia independent of other pathologies. Although LATE-NC has a large impact on public health, there remain uncertainties about the underlying biologic mechanisms. Here, we review the literature from human studies that may shed light on pathogenetic mechanisms. It is increasingly clear that certain combinations of pathologic changes tend to coexist in aging brains. Although “pure” LATE-NC is not rare, LATE-NC often coexists in the same brains with Alzheimer disease neuropathologic change, brain arteriolosclerosis, …

Using Knowledge Of Human Factors To Strengthen Highway Design, Chris Van Dyke, Jeff Jasper, Jill Asher, Steve Waddle

Kentucky Transportation Center Research Report

Transportation practitioners recognize that leveraging knowledge of human factors in road design is critical for delivering safe mobility to the full spectrum of multimodal road users (motorists, pedestrians, micromobility users, transit users). Understanding how psychology, cognition, and behavioral tendencies shape the ways in which different road users interact with one another and the road environment itself is critical for creating design solutions that promote safe and efficient movement. NCHRP Report 600 (Human Factors Guidelines for Road Systems) provides guidance on integrating knowledge of human factors into design practice. While the report is a valuable resource, it appears to …

Coordinated Controls Of Residential Ev Chargers Considering High Power Appliances, Steven B. Poore, Rosemary E. Alden, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

In addition to electric vehicle (EV) adoption, the electricity demand of the modern grid is also under change from the replacement of resistive electric water heaters (EWHs) with high-efficiency heat pump electric water heaters (HPWH). Typical load of a HPWH has two parts: a low power compressor and a backup high power resistive boosting element. Within this paper, residential load from a large field demonstration for over one thousand homes is simulated in virtual power plant (VPP) operation with realistic HPWH and EV synthetic modules based on big data from the latest CBECC-Res and National Household Travel Survey (NHTS). Simultaneous …

Comparative Analysis Of Motors With Inner And Outer Reluctance Rotors And Pm Stators, Oluwaseun A. Badewa, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

This paper presents a comparison of special outer and inner reluctance rotor motor topologies with permanent magnet (PM) stators having toroidal AC windings. A systematic approach is taken to study and discuss the design geometries, the respective impact on performance, and adoption of technological advancements such as stator-only cooling and hair-pin winding for high slot fill factor. Parametric FEA models are developed for both topologies, and design of experiments (DoE)-based sensitivity analysis is used to study the effect of independent variables on specific performance metrics such as torque, motor loss, torque ripple, and power factor. Inner and outer rotor topologies …

Sensorless Control Of Low Inductance Coreless Afpm Machines For Fault-Tolerant Operation Of Propulsion Systems, Yaser Chulaee, Ali Mohammadi, Aaron M. Cramer, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

In motor-drive systems utilized in safety-critical applications and demanding conditions like electric aircraft propulsion systems, the reliability of the system is greatly affected by position sensors, given their susceptibility within the motor drive system. Consequently, there is a need to eliminate sensors in vector-controlled motor drives to decrease overall hardware complexity and expenses, bolster the mechanical durability and dependability of the drive system. In this paper, a fault-tolerant sensorless control system for low inductance coreless axial flux PM (AFPM) machines, integrated into electric aircraft propulsion systems, is introduced. The proposed control system spans a wide operating range, from zero to …

Fault-Tolerant Axial Flux Coreless Pm Machines With Independent Phase Modules, Yaser Chulaee, Ali Mohammadi, Dan M. Ionel, Matin Vatani

Electrical and Computer Engineering Graduate Research

In this paper, a fault-tolerant two-phase high power coreless axial flux PM (AFPM) machine with a modular structure is introduced. The performance of this machine, in terms of torque, power density, and efficiency, is compared with its three-phase counterpart configuration based on finite element analysis (FEA) and experimental results. The fault tolerance of these two configurations, considering the control systems, is also compared. A detailed power loss breakdown for the prototype two-phase and three-phase printed circuit board (PCB) stator coreless AFPM machines derived from experiments is presented, showcasing that the introduced fault-tolerant two-phase machine has comparable performance and efficiency, while …

High-Power Polyphase Pcb-Type Inductive Coupler For Wireless Electric Vehicle Charging, Donovin D. Lewis, Omer Onar, Lucas Gastineau, John F. Eastham, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

The cost and manufacturing difficulty of traditionally wound coils for wireless charging of electric vehicles has led to the exploration of alternative manufacturing for scalable deployment at a range of rated powers. A rotating-field polyphase wireless coupler is developed with balanced fully pitched coils which are not possible with conventional Litz wire. The usage of printed circuit board (PCB) technology is proposed for the innovative construction at large dimensions due to reduced cost, increased ease of manufacturability, and potential geometric customization compared to would coils. Design considerations specific to PCBs are detailed for wireless power transfer coils including advantages such …

Comparative Analysis Of Vernier Machines With Spoke, Surface Mounted, And Halbach Pm Rotors For In-Wheel Traction, Ali Mohammadi, Aaron M. Cramer, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

Axial-flux Permanent Magnet (AFPM) machines are well-suited for in-wheel traction in electric vehicles due to their compact structure and higher torque density. This paper presents a large-scale design optimization of an axial-flux permanent magnet vernier machine (PMVM) of the MAGNUS type with a double stator configuration. The active stator features double layer wound coils, while the passive stator is unwound but has a similar profile. The reference design employs a rotor with permanent magnets (PMs) arranged in a spoke-type field intensifying pattern, providing high flux concentration. Design optimization was performed using 3-D electromagnetic Finite Element Analysis (FEA) and the Differential …

On The Optimal Design Of Coreless Afpm Machines With Halbach Array Rotors For Electric Aircraft Propulsion, Matin Vatani, Yaser Chulaee, Ali Mohammadi, David R. Stewart, John F. Eastham, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

This paper presents and evaluates the optimal design of a coreless axial flux permanent magnet (AFPM) motor for electric aircraft propulsion. Ferromagnetic cores are entirely removed from the machine’s structure to improve the specific power density and efficiency. An approach for envelope design optimization of the proposed motor is introduced, considering the polarity as an independent variable and employing an evolutionary algorithm and 3D Finite Element Analysis (FEA). In addition to the proposed electric motor’s electromagnetic performance, fault-tolerant capability and thermal management are considered in the optimization procedure. The optimization results and similar studies from power electronic and thermal management …

Association Of Circulating Markers Of Microbial Translocation And Hepatic Inflammation With Liver Injury In Patients With Type 2 Diabetes, Leila Gobejishvili, Vatsalya Vatsalya, Diana V. Avila, Yana B. Feygin, Craig J. Mcclain, Sriprakash Mokshagundam, Shirish Barve

Biostatistics Faculty Publications

Background: Virtually the entire spectrum of liver disease is observed in association with type 2 diabetes mellitus (T2DM); indeed, T2DM is now the most common cause of liver disease in the U.S. We conducted a pilot study to investigate the relevance of increased microbial translocation and systemic inflammation in the development of liver injury in patients with T2DM. Methods: Patients with T2DM (n = 17) and non-diabetic controls (NDC; n = 11) aged 25–80 yrs. participated in this study. Serum levels of endotoxin, calprotectin, soluble CD14 and CD163, and several inflammatory cytokines were measured. In addition to standard liver injury …

The Value Of Flexible Funding For Collaborative Biostatistics Units In Universities And Academic Medical Centres, Emily Slade, Sarah Jane K. Robbins, Kristen J. Mcquerry, Anthony A. Mangino

Biostatistics Faculty Publications

Collaborative biostatistics units within universities and academic medical centres operate under a wide range of different funding models; common to many of these models is the challenge of allocating time to activities that are not linked to a specific research project, such as professional development, mentorship and administrative tasks. The purpose of this paper is to describe a proposed model for ‘flexible funding’, that is, funding that is not linked to a specific research project, within a collaborative biostatistics unit and to detail the benefits and challenges associated with the proposed model. We present results from a qualitative study representing …

Working Well With Statisticians, Ryan A. Peterson, Emily Slade, Gina Maria Pomann, Walter T. Ambrosius

Biostatistics Faculty Publications

Statistical collaboration requires statisticians to work and communicate effectively with nonstatisticians, which can be challenging for many reasons. To identify common themes and lessons for working smoothly with nonstatistician collaborators, two focus groups of primarily academic collaborative statisticians were held. We identified qualities of collaborations that tend to yield fruitful relationships and those that tend to yield nothing (or worse, with one or both parties being dissatisfied). The initial goal was to share helpful knowledge and individual experiences that can facilitate more successful collaborative relationships for statisticians who work within academic statistical collaboration units. These findings were used to design …

Evaluation Of Ten Alternative Treatments For The Management Of Harlequin Bug (Murgantia Histrionica) On Brassica Crops, Sarah Clark, Ricardo Bessin, David J. Gonthier, Jonathan L. Larson

Entomology Faculty Publications

Harlequin bug (Murgantia histrionica) poses a significant threat to cruciferous vegetable crops, leading to economic losses and challenges in sustainable agriculture. This 2-year field study evaluated the efficacy of exclusion netting and selected biopesticides in controlling harlequin bug populations in a field-grown broccoli crop. Treatments included an untreated control, industry standards Azera and Entrust, and ProtekNet mesh netting. Additionally, three commercial essential oil treatments including Essentria IC-3, Nature-Cide, and Zero Tolerance were tested along with two bokashi fermented composting products BrewKashi and Oriental Herbal Nutrient (OHN). During both the first and second year of the study, none of the commercially …

Row Covers Limit Pests And Disease And Increase Profit In Organic Acorn Squash, Kathleen Fiske, Nieyan Cheng, Ryan Kuesel, Wendong Zhang, Ricardo Bessin, Mark A. Williams, David J. Gonthier

Entomology Faculty Publications

Organic cucurbit growers face many challenges to production including insect pests, insect-vectored diseases, and non-vectored diseases. While Organic Material Review Institute (OMRI) -listed pesticides underperform at suppressing pests and diseases, some alternative pest management strategies hold promise, but little research exists on their cost-effectiveness. We compared the efficacy of mesotunnel systems (nylon-mesh netting row covers deployed over bent metal hoops) and OMRI-listed pesticides (fungicides and insecticides) on acorn squash across 2 years. During the early part of the season, before row covers were removed for pollination, we found 1.7 (2020) and 0.3 (2021) times more cucumber beetles in the uncovered …

Snpaimer: R Package For Evaluating Ancestry Informative Marker Contributions In Non-Model Population Diagnostics, Kim L. Vertacnik, Oksana V. Vernygora, Julian R. Dupuis

Entomology Faculty Publications

Motivation: Single nucleotide polymorphism (SNP) markers are increasingly popular for population genomics and inferring ancestry for individuals of unknown origin. Because large SNP datasets are impractical for rapid and routine analysis, diagnostics rely on panels of highly informative markers. Strategies exist for selecting these markers, however, resources for efficiently evaluating their performance are limited for non-model systems.

Results: snpAIMeR is a user-friendly R package that evaluates the efficacy of genomic markers for the cluster assignment of unknown individuals. It is intended to help minimize panel size and genotyping effort by determining the informativeness of candidate diagnostic markers. Provided genotype data …

Staufenc Facilitates Utilization Of The Erad Pathway To Transport Dsrna Through The Endoplasmic Reticulum To The Cytosol, Jinmo Koo, Subba R. Palli

Entomology Faculty Publications

RNA interference (RNAi) is more efficient in coleopteran insects than other insects. StaufenC (StauC), a coleopteran-specific double-stranded RNA (dsRNA)-binding protein, is required for efficient RNAi in coleopterans. We investigated the function of StauC in the intracellular transport of dsRNA into the cytosol, where dsRNA is digested by Dicer enzymes and recruited by Argonauts to RNA-induced silencing complexes. Confocal microscopy and cellular organelle fractionation studies have shown that dsRNA is trafficked through the endoplasmic reticulum (ER) in coleopteran Colorado potato beetle (CPB) cells. StauC is localized to the ER in CPB cells, and StauC-knockdown caused the accumulation of dsRNA in the …

Effects Of The “High Impact Leadership For School Renewal” Project On Principal Leadership, School Leadership, And Student Achievement, Xin Ma, Jianping Shen, Patricia L. Reeves, Huang Wu, La Sonja Roberts, Yunzheng Zheng, Qianqian Chen

Educational, School, and Counseling Psychology Faculty Publications

In this study, we designed an educational experiment to evaluate the High Impact Leadership for School Renewal project’s impact on principal leadership, school leadership, and student achievement. Principals in the experimental group reported statistically significantly greater improvement in principal leadership than their counterparts in the control group (Hedge’s g of 0.73), but teachers in the experimental and control groups showed no difference in their ratings of principal leadership. Teachers in the experimental group reported statistically significantly more improvement in school leadership than their counterparts in the control group (Hedge’s g of 0.53 on the scale of Orientation to School Renewal …

Single-Cell Analysis Identifies Plk1 As A Driver Of Immunosuppressive Tumor Microenvironment In Luad, Yifan Kong, Chaohao Li, Jinpeng Liu, Sai Wu

Markey Cancer Center Faculty Publications

PLK1 (Polo-like kinase 1) plays a critical role in the progression of lung adenocarcinoma (LUAD). Recent studies have unveiled that targeting PLK1 improves the efficacy of immuno- therapy, highlighting its important role in the regulation of tumor immunity. Nevertheless, our understanding of the intricate interplay between PLK1 and the tumor microenvironment (TME) remains incomplete. Here, using genetically engineered mouse model and single- cell RNA-seq analysis, we report that PLK1 promotes an immunosuppressive TME in LUAD, characterized with enhanced M2 polarization of tumor associated macrophages (TAM) and dampened antigen presentation process. Mechanistically, elevated PLK1 coin- cides with increased secretion of CXCL2 …

Smoking Cessation By Cancer Treatment Status Among Cervical Cancer Survivors, Cherell Cottrell-Daniels, Charles E. Hoogland, Bethany Shorey Fennell, Vani N. Simmons, Damon J. Vidrine, Jennifer I. Vidrine

Markey Cancer Center Faculty Publications

Introduction: Continued smoking following a cancer diagnosis is associated with poorer cancer treatment outcomes and survival times. Little is known about how cancer treatment status at the time of tobacco treatment enrollment impacts long-term smoking cessation outcomes. Using data from a smoking cessation RCT, this study compared long-term cessation outcomes of women undergoing active treatment for cervical cancer at trial enrollment (n=40) to outcomes of women with a history of cervical cancer or cervical intraepithelial neoplasia (CIN) who were not undergo- ing active cancer treatment at enrollment (n=154)

Methods: Participants (n=194) were randomized to Standard Treatment (ST) or ST plus …

Heart Failure In Nursing Homes: A Scoping Review Of Educational Interventions For Optimising Care Provision, James Mcmahon, David R. Thompson, Jan Cameron, Christine Brown Wilson, Loreena Hill, Paul Tierney, Doris Yu, Debra K. Moser, Karen Spilsbury, Nittaya Srisuk, Jos M. G. A. Schols, Mariëlle Van Der Velden, Gary Mitchell

UK CARES Faculty Publications

Background: Heart failure has an estimated global prevalence of 64.3 million cases, with an average age of a person living with heart failure at 75.2 years. Approximately 20% of residents living in nursing homes (a long-term residential care environment for some individuals) report living with heart failure. Residents living with heart failure in nursing home environments are often frail, have reduced quality of life, higher rates of rehospitalisation and mortality, and greater complications in heart failure management. Further, nursing home staff often lack the knowledge and skills required to provide the necessary care for those living with heart failure. Interventions …

Active And Retroactive Digital Newspaper Preservation, Andrew Mcdonnell

Library Presentations

This presentation was given at the 2024 International Federation of Library Associations and Institutions News Media Conference in Aarhus, Denmark on May 31, 2024. It illustrates a brief glimpse of the University of Kentucky's Digital Newspaper Preservation program, highlighting challenges presented by two new born-digital additions to the collection.