Digital Commons Network^™

Quantum Hall Phases In Monolayer Graphene, Jincheng An

Theses and Dissertations--Physics and Astronomy

In the presence of a perpendicular magnetic field, monolayer graphene at and near charge neutrality forms a quantum Hall ferromagnet—a correlated electronic state where the interplay of interactions, spin, and valley degrees of freedom leads to spontaneous symmetry breaking. While the dominant Coulomb interaction has $SU(4)$ symmetry, the ground state is ultimately determined by subdominant terms: residual lattice-scale anisotropic interactions, Zeeman, and sublattice couplings. Relaxing the ultra-short-range limit of anisotropic interactions unveils diverse symmetry-breaking phases in both integer and fractional quantum Hall regimes. Haldane pseudopotentials, which quantify interactions between particle pairs with fixed relative angular momentum, provide a readily parameterizable …

Diet And Migration In The Prehistoric Populations In The Greater Nicoya Region Of Nicaragua, Ashley Nichols Whitten

Theses and Dissertations--Anthropology

The goal of this three-paper dissertation was to engage with the archaeological hypotheses of prehistoric migration from Mesoamerica into the Greater Nicoya Region of Nicaragua. To that aim, this dissertation contains a discussion on the current information supporting and refuting the migratory hypotheses. New data is also presented in the form of stable isotope analysis and bioarcheological analysis of dentition from prehistoric archaeological sites in Pacific Nicaragua.

The first paper titled “Prehistoric Foodways and Migration Hypotheses in the Greater Nicoya Region of Nicaragua” outlines the current available research concerning migration out of Mesoamerica into Pacific Nicaragua. The potential migration is …

Free Food And The Fabric Of Need: Moralized And Institutionalized Care Within Kentucky Charitable Food Programs, Alisha D. Mays

Theses and Dissertations--Anthropology

This dissertation offers a critical ethnographic examination of hunger and charitable food programs (CFPs) in rural Eastern Kentucky, situated within the broader political economy of welfare retrenchment and neoliberal governance in the United States. Through multi-sited fieldwork spanning food pantries, mutual aid networks, state and federal partner agencies, and the regional food bank system, I analyze how hunger is experienced, managed, and framed by clients, volunteers, and organizational staff.

This work uses qualitative methods to weave the lived experiences across intersecting charitable food systems; this dissertation contributes to economic anthropology by illuminating the relational and political dimensions of hunger in …

Precision Measurement Of The Muon’ S Anomalous Precession Frequency Using Energy Integrated Analysis In The Fermilab Muon G- 2 Experiment, Joseph Peck

Theses and Dissertations--Physics and Astronomy

This dissertation investigates the anomalous magnetic moment of the muon, aµ, through the Fermilab Muon g -2 Experiment, which aims to measure aµ to a precision of about 140 parts-per-billion.

Muons were injected into a magnetic storage ring where their decay positrons were detected by calorimeters. The changing spin and momentum orientation leads to an oscillation in decay positron counts, known as the anomalous precession frequency ! a. Using the magnetic field and !a measurements, we can determine the value of a µ. This study focuses on the Q-Method determination of !a, which utilizes an energyintegrated reconstruction rather than high-energy …

A Multidisciplinary Approach To The Thermal And Non-Thermal Mechanisms In Galaxy Clusters, Sheng-Chieh Lin

Theses and Dissertations--Physics and Astronomy

Galaxy clusters form at the intersections of the cosmic web and carry imprints of the structure formation history of the universe. As massive, multi-component systems, they offer unique insights into the astrophysical processes that govern both structure formation and galaxy evolution. Observable across the full electromagnetic spectrum, clusters emit photons through a variety of mechanisms, each tracing different physical processes. This dissertation investigates both the thermodynamic and non-thermal properties of the intracluster medium (ICM) to better understand the physical processes shaping observed phenomena. It comprises three main studies, each targeting a different aspect of galaxy cluster physics. In the second …

Community Health Worker-Delivered Tobacco Cessation In A Small Rural County, Ellen J. Hahn, Amanda Bucher, Amanda T. Wiggins, Kathy Rademacher, Whitney Beckett, Leeann Taylor, Audrey Darville, Jean Edward

BREATHE Faculty Publications

Purpose: We evaluated a Community Health Worker (CHW)-Tobacco Treatment Specialist (TTS) model for delivering tailored tobacco treatment counseling and support in a rural, low-resourced county.

Methods: This was an exploratory, prospective study of people 18 years or older who used any tobacco product including e-cigarettes or vapes in the past 30 days. The CHW assessed tobacco use, secondhand smoke exposure, and quit history; and collected an expired breath carbon monoxide sample and a brief health history before providing 4–6 in-person or phone-based sessions involving tailored tobacco treatment counseling and support. The CHW connected participants to a prescriber at a federally …

Implementing And Evaluating A Pilot Interprofessional Training Program To Engage Health Care Teams In Cost Of Care Conversations, Jean Edward, Kimberly D. Northrip, Mary Kay Rayens, Julia Costich, Andrea Welker, Rachel O’Farrell, John A. D'Orazio

Nursing Faculty Publications

Introduction: This study evaluated the impact of Financial and Insurance Navigation Assistance-Training – a pilot interprofessional training program to facilitate cost of care (CoC) conversations and address health-harming social determinants of health in a pediatric hematology–oncology clinic.

Methods: A pre–post study design was used to evaluate the impact of Financial and Insurance Navigation Assistance-Training on an interprofessional health care team's (clinicians, social workers, financial navigator, and legal advocates) knowledge, attitudes, and behaviors related to CoC conversations and screening, referring, and collaborating with interprofessional team members. Data were collected …

Diet Quality Mediates The Relationship Between Chronic Stress And Inflammation In Patients With Metabolic Syndrome, Junghee Kang, Debra K. Moser, Terry A. Lennie, Misook L. Chung, D. Travis Thomas, Martha J. Biddle

Nursing Faculty Publications

Background 

Chronic stress is associated with promotion of inflammation and development of metabolic syndrome, as well as deterioration of diet quality. Inflammation can be modified by changes in dietary intake.

Objective 

The aim of this study was to test the hypothesis that diet quality mediates the relationship of chronic stress with inflammation in patients with metabolic syndrome.

Methods 

Participants with metabolic syndrome (n = 73, 62 ± 12 years old, 71% female) completed questionnaires on chronic stress (Perceived Stress Scale-10) and diet quality (Healthy Eating Index-2020). The Perceived Stress Scale-10 was dichotomized. The Healthy Eating Index-2020 score was used as …

Championing Reproductive And Perinatal Health With The Recovery Community: Improving Access To Healthcare And Health Promotion Resources To Support Recovery, Hartley C. Feld, Alex Elswick, Jeremy Byard, Whitney Beckett, Amanda Fallin-Bennett

Nursing Faculty Publications

Peer recovery support services are instrumental in the promotion of long-term recovery primarily by focusing on building the recovery capital of people with substance use disorders. Women may have specific health-related needs that are not generally part of recovery support staff training. Our team co-created a model by training people with lived experience as coaches to promote the health of women with SUD during the critical period of their reproductive years when mortality from overdose risk is high and can be compounded by issues surrounding pregnancy. We explored the outcomes of a small pilot test of this model to promote …

Degree Of Rurality Moderates The Association Of Sedentary Time With Cognitive Function In Rural Patients With Cardiac Diseases And Depressive Symptoms, Chin-Yen Lin, Jia-Rong Wu, Geunyeong Cha, Junghee Kang, Martha J. Biddle, Misook L. Chung, Ashmita Thapa, Mary Kay Rayens, Linda Gibson-Young, Debra K. Moser

Nursing Faculty Publications

Background: Prolonged sedentary time has been linked to impaired cognitive outcomes. However, the impact of sedentary time on cognitive function at different degrees of rurality is not yet well understood in patients with cardiac diseases and depressive symptoms.

Purpose: To determine whether degree of rurality moderates the relationship between sedentary time and cognitive function.

Methods: This study includes 135 coronary heart disease or heart failure patients, primarily residing in rural Kentucky, including Appalachian areas, United States. Sedentary time was measured by the average daily sedentary time (in minutes) using accelerometry (ActiGraph). Cognitive function was assessed using the Montreal Cognitive Assessment-Blind. …

Challenges And Lessons Learned While Conducting A Diabetes Prevention Program Among Black Churches During The Covid-19 Pandemic, Erika R. Karle, Destiny Cozart, Bassema Abu Farsakh, Victor Afolayan, Treasure Ebikwo, Maranda Brooks, Lovoria B. Williams

Nursing Faculty Publications

We share our experiences conducting a 5-year randomized controlled diabetes prevention project among 20 Black churches in central Kentucky during the COVID-19 pandemic and offer strategies to inform future church-based interventions. Researchers have long recognized the potential to reach Black adults in church settings for health promotion interventions and have implemented trials within this socially rich setting. However, there is a dearth of literature that describes the challenges and lessons learned while conducting these trials. We describe the challenges we experienced and the strategies we used to overcome them to successfully conduct the trial. During the study, we maintained detailed …

Hpv Self-Sampling Promotion Among African American (Aa) And Sub-Saharan African (Sai) Immigrant Women: Adaptation And Usability Testing, Adebola Adegboyega, Gia Mudd-Martin, Nancy Schoenberg, Mark Dignan

Nursing Faculty Publications

Background: Cervical cancer (CC) rates have declined nationally but rates remain high in Black women with most cases occurring among unscreened and under-screened women. This paper describes the adaptation, acceptability, and useability of an education intervention, “Health is Wealth: A Cervical Health Intervention”, to promote cervical screening and reduce perceived barriers to CC screening among two subgroups of Black women: African American (AA) and sub-Saharan African immigrant (SAI) women.

Methods: In this paper, we describe the process of adapting the Health is Wealth intervention using the Barrera and Castro adaptation framework. The iterative adaptation process included formative focus groups (n …

An Ethnography Of Love Jihad: The Governance Of Interfaith Marriages In Times Of Hindutva, Snehal Sharma

Theses and Dissertations--Gender and Women's Studies

My doctoral research focuses on the violations of human and citizenship rights of women and religiously marginalized communities (based on religious differences) in the backdrop of right-wing movements in India. I assess the Hindu nationalist propaganda named “love jihad” to demonstrate the way it weaponizes religious exogamy. This propaganda legitimizes violence against Indian religious minorities and women as it claims that marriages between Hindu women and Muslim men are acts of terrorism against Hindus with the sole aim of increasing the Muslim population using Hindu women's bodies. I have used ethnographic research methods to explore the legal process of interfaith …

How To Eat Right And Why We Ask That Question, Heather N. Carpenter

Theses and Dissertations--Gender and Women's Studies

What does it mean to “eat right?” The notion is, of course, culturally, historically, nationally, politically, ethnically, and class determined. For the purposes of this project, however, I am particularly interested in changing notions of what it means to “eat right” within the post-World War II to the early new millennium American context, as such notions are represented within the prescriptions of popular culture. I turn to popular culture because this is the commons of the hegemonic call to “normalcy”—this is where we all learn to imitate, aspire, or rebel against a generic American consumer-self in conformity with the biases, …

Alternative Visions Of Swedish State Feminism, Lukas Bullock

Theses and Dissertations--Gender and Women's Studies

Sweden has been lifted as a prominent example of a successful feminist policy enactor, and has built credibility as a humanitarian actor both domestically and transnationally. Simultaneously, intersectionally marginalized groups have attested to patterns of social exclusion and feelings of political disenfranchisement in Swedish society, calling into question Sweden’s reputation for feminist exceptionalism. This dissertation project centers on unpacking this dynamic by examining how Swedish gender equality policymaking institutions design and implement feminist policy, and how those efforts are interpreted and contested by intersectionally marginalized groups of Afro-Swedish feminist activists. Drawing from a mixed-methods framework that includes feminist ethnography (interviews, …

Fatal Futures: Slow Violence, Utopia, And The Postnatural Human In Contemporary American Literature, Shelby Roberts

Theses and Dissertations--English

Fatal Futures: Slow Violence, Utopia, and the Postnatural Human in Contemporary American Literature investigates the ways in which ideas of futurity are articulated in narratives that conceptualize both the end of the world and post-calamity society through the lens of a pessimistic, queer approach to understanding the future. The purpose of this project is to not only build previous research in the configurations of the body in queer, gothic, and speculative American writing as a whole, but to enter into a developing conversation surrounding Appalachian literature through the idea of kinship (the broadening of relationships both chemical and postnatural) as …

Proximity And Density Of Tobacco Retail Locations To Kentucky Schools And The Relationship To Youth Perceptions Of Harm And Susceptibility To E-Cigarette Use, Hannah Cardona

Theses and Dissertations--Kinesiology and Health Promotion

Purpose: To explore the potential relationship between tobacco retailer proximity/density around Kentucky elementary, middle, and high schools, and students’ perceptions, perceived norms, susceptibility to, and use of e-cigarettes. Design: A mixed-methods analysis of youth’s self-reported survey results and geographical data. Setting: 106 Kentucky elementary, middle, and high schools which participated in #iCANendthetrend’s tobacco education program between September 2023 and May 2024. Subjects: Convenience sample of students from Ky schools (N = 7,823) Measures: Items assessing e-cigarette use, susceptibility, perceptions, and perceived norms. Analysis: ANOVA tests used to compare responses of elementary, middle, and high school students. Chi-squared tests were used …

Psychological Impacts In Exercise Riders And Professional Jockeys Following Injury, Kelley M. Renner

Theses and Dissertations--Kinesiology and Health Promotion

One of the most well-known equestrian sports, horse racing, is not only a cornerstone of Kentucky’s economy, but also a vital part of its culture, with professional jockeys playing an essential role in the local communities and traditions that define the state. Despite its popularity and financial impact, mental health challenges within the sport have continually been shrouded in silence and ignored in research (Ball et al., 2007). Equally concerning is the high injury prevalence, and psychological impact of these injuries (e.g., psychological distress, depression, anxiety, loss of identity, and self-esteem (King et al., 2022; Losty et al., 2019; McConn-Palfreyman …

Bridging Awareness And Access: Outdoor Recreation And Physical Activity In Eastern Kentucky, Timothy Mckay

Theses and Dissertations--Kinesiology and Health Promotion

Physical inactivity remains a pressing challenge in Appalachian Kentucky, where high obesity rates intersect with limited access to structured exercise facilities. This dissertation investigated the extent to which participation in outdoor recreation supports adherence to physical activity (PA) recommendations and explored community awareness of local public lands. Surveys from 52 adult participants in Knox County revealed strong engagement in outdoor activity, with participation significantly predicting compliance with national PA guidelines. Educational attainment was also associated with higher rates of PA compliance, pointing to the influence of literacy and awareness in health behaviors. Reliability testing of the Outdoor Physical Activity Attitude …

Exploring College Students’ Motivation For Physical Activity: Applications Of Self-Determination Theory And The Role Of Health And Wellness Education, Anne Russell Blevins

Theses and Dissertations--Kinesiology and Health Promotion

This dissertation includes three pieces of writing that aim to show the importance of physical activity for all ages but specifically college-aged students. The first piece of writing (Chapter 2) includes a teaching tip written for the Journal of Physical Education, Recreation, and Dance. Research has shown that dance was a subject of the past and many teachers did not feel comfortable teaching it. This practical piece was written to help show K-12 physical education teachers effective ways to involve students in physical activity specifically through teaching dance, mainly through using the “Teaching Dance for Understanding” model.

The second section …

Reevaluating The Opportunity For Wind Energy In Kentucky: Advancing Technology, Changing Economics, And Generation Complementarity, Lawrence E. Holloway, Aron Patrick, Dan M. Ionel

Electrical and Computer Engineering Faculty Publications

Recent developments in wind turbine technology, new wind resource data, and new federal tax credits for renewable energy are increasing the suitability of wind electricity generation in Kentucky. In 2022, Kentucky had 68% of its electricity from coal and in 2023 was one of eight U.S. states with no utility-scale wind generation. In the past, the state has been viewed as being generally unsuitable for wind power generation. While wind is not the most economic resource in Kentucky, all states bordering the Commonwealth have wind power. Wind power generation in Kentucky appears increasingly likely in the coming decades to play …

A Review Of The Association Between Dietary Intake And Brain Iron Levels In Older Adults: Preliminary Findings And Future Directions., Valentinos Zachariou, Christopher E. Bauer, Colleen A. Pappas, Brian T. Gold

Behavioral Science Faculty Publications

Background/Objectives: Non-heme iron is essential for critical neuronal functions such as ATP generation, synaptogenesis, neurotransmitter synthesis, and myelin formation. However, as non-heme iron accumulates with age, excessive levels can contribute to oxidative stress, potentially disrupting neuronal integrity and contributing to cognitive decline. Despite growing evidence linking high brain iron with poorer cognitive performance, there are currently no proven methods to reduce brain iron accumulation in aging or to protect cognitive function from iron’s negative effects. Recent studies suggest that nutrition may influence brain iron levels, though the evidence remains limited and mixed. Methods: In this review, we explore recent findings, …

Differential Infiltration Of Key Immune T-Cell Populations Across Malignancies Varying By Immunogenic Potential And The Likelihood Of Response To Immunotherapy., Islam Eljilany, Sam Coleman, Aik Choon Tan, Martin D. Mccarter, John Carpten, Howard Colman, Abdul Rafeh Naqash, Igor Puzanov, Susanne Arnold, Michelle L. Churchman, Daniel Spakowicz, Bodour Salhia, Julian Marin, Shridar Ganesan, Aakrosh Ratan, Craig Shriver, Patrick Hwu, William S. Dalton, George J. Weiner, Jose R. Conejo-Garcia, Paulo Rodriguez, Ahmad A. Tarhini

Markey Cancer Center Faculty Publications

Background: Solid tumors vary by the immunogenic potential of the tumor microenvironment (TME) and the likelihood of response to immunotherapy. The emerging literature has identified key immune cell populations that significantly impact immune activation or suppression within the TME. This study investigated candidate T-cell populations and their differential infiltration within different tumor types as estimated from mRNA co-expression levels of the corresponding cellular markers.

Methods: We analyzed the mRNA co-expression levels of cellular biomarkers that define stem-like tumor-infiltrating lymphocytes (TILs), tissue-resident memory T-cells (TRM), early dysfunctional T-cells, late dysfunctional T-cells, activated-potentially anti-tumor (APA) T-cells and Butyrophilin 3A (BTN3A) isoforms, utilizing …

Population-Based Cross-Sectional Analysis Of Cannabis Use Among Kentucky Adults, 2020– 21, Sydney Shafer, Gunnar Kennedy, W. Jay Christian

UK CARES Faculty Publications

Purpose We conducted this study to assess cannabis use rates in the state of Kentucky relative to socioeconomic, demographic, and geographic factors, as well as reasons for use and modes of use, before the legal medical marijuana market commences in 2025.

Methods We pooled Kentucky Behavioral Risk Factor Surveillance System (BRFSS) data for 2020–2021 and used weighted responses for all analyses. We estimated current cannabis use (at least once in the past 30 days), and heavy use (at least 20 of the past 30 days) prevalence rates for Appalachian, Delta, and Central geographic regions of Ken- tucky. We tabulated descriptive …

Students Participating As Ambassadors For Research In Kentucky (Spark): A Health Equity Undergraduate Research Training Program, Ariel A. Arthur, Rebecca L. Delacerda Allen, Fidelis Y. Sesenu, Maxwell A. Groznik, Carrie B. Oser, Madeline Dunfee, Philip A. Kern, Nancy Schoenberg

UK CARES Faculty Publications

The Students Participating as Ambassadors for Research in Kentucky (SPARK) program provides novel health equity research training and targeted mentorship for undergraduates, particularly those from groups underrepresented in the biomedical and behavioral research and workforce. SPARK aims to address inadequate diversity in the medical and scientific research fields by providing comprehensive research mentorship and skill-building. Unlike most existing research training programs that are brief, focus on laboratory research, or are limited to graduate students and junior faculty, SPARK delivers a 16-month intensive behavioral and population health science training, equipping students with needed tools to conceptualize, plan, execute, and analyze their …

Microbial Community Assembly Across Agricultural Soil Mineral Mesocosms Revealed By 16s Rrna Gene Amplicon Sequencing Data, Daniel Lee, Fernanda C C Oliveira, Richard T. Conant, Minjae Kim

UK CARES Faculty Publications

Increasing atmospheric carbon dioxide (CO 2 ) concentrations are impacting the global climate, resulting in significant interest in soil carbon sequestration as a mitigation strategy. While recognized that mineral-associated organic matter (MAOM) in soils is mainly formed through microbial activity, our understanding of microbial-derived MAOM formation processes remains limited due to the complexity of the soil environment. To gain insights into this issue, we incubated fresh soil samples for 45 days with one of three mineral additions: Sand, Kaolinite+Sand, or Illite+Sand. 16S rRNA V3/V4 gene amplicon sequencing was then conducted on samples using an Illumina NextSeq 20 0 0 flow …

Myosin Xva Isoforms Participate In The Mechanotransduction-Dependent Remodeling Of The Actin Cytoskeleton In Auditory Stereocilia, Ana I. López-Porras, Ava M. Kruse, Mark T. Mcclendon, A. Catalina Vélez-Ortega

Neurology Faculty Publications

Auditory hair cells form precise and sensitive staircase-like actin protrusions known as stereocilia. These specialized microvilli detect deflections induced by sound through the activation of mechano-electrical transduction (MET) channels located at their tips. At rest, a small MET channel current results in a constant calcium influx which regulates the morphology of the actin cytoskeleton in the shorter ‘transducing’ stereocilia. However, the molecular mechanisms involved in this novel type of activity-driven plasticity in the stereocilium cytoskeleton are currently unknown. Here, we tested the contribution of myosin XVA (MYO15A) isoforms, given their known roles in the regulation of stereocilia dimensions during hair …

Targeted Long-Read Sequencing To Quantify Methylation Of The C9orf72 Repeat Expansion, Evan Udine, Nicole Finch, Mariely Dejesus-Hernandez, Jazmyne L. Jackson, Matthew C. Baker, Siva Arumugam Saravanaperumal, Eric Wieben, Mark T. W. Ebbert, Jaimin Shah, Leonard Petrucelli, Rosa Rademakers, Björn Oskarsson, Marka Van Blitterswijk

Neurology Faculty Publications

Background The gene C9orf72 harbors a non-coding hexanucleotide repeat expansion known to cause amyotrophic lateral sclerosis and frontotemporal dementia. While previous studies have estimated the length of this repeat expansion in multiple tissues, technological limitations have impeded researchers from exploring additional features, such as methylation levels.

Methods We aimed to characterize C9orf72 repeat expansions using a targeted, amplification-free long-read sequencing method. Our primary goal was to determine the presence and subsequent quantification of observed methylation in the C9orf72 repeat expansion. In addition, we measured the repeat length and purity of the expansion. To do this, we sequenced DNA extracted from …

Alternatives To Dental Opioid Prescribing After Tooth Extraction (Adopt), Douglas R. Oyler, Philip M. Westgate, Sharon L. Walsh, Jennifer Dolly Prothro, Craig S. Miller, Monica F. Roberts, Patricia R. Freeman, Hannah K. Knudsen, Maggie Lang, Enif Dominguez-Fernandez, Marcia V. Rojas-Ramirez

Biostatistics Faculty Publications

Background: Dentists and oral surgeons are leading prescribers of opioids to adolescents and young adults (AYA), who are at high risk for developing problematic opioid use after an initial exposure. Most opioids are prescribed after tooth extraction, but non-opioid analgesics provide similar analgesia and are recommended by multiple professional organizations. Methods: This multi-site stepped wedge cluster-randomized trial will assess whether a multicomponent behavioral intervention can influence opioid prescribing behavior among dentists and oral surgeons compared to usual practice. Across up to 12 clinical practices (clusters), up to 33 dentists/oral surgeons (provider participants) who perform tooth extractions for individuals 12–25 years …

Independent Evolution Of Oleate Hydratase Clades In Bacillales Reflects Molecular Convergence, Robert J. Neff, Priscilla C. Lages, Shannon K. Donworth, James D. Brien, Christopher D. Radka

Markey Cancer Center Faculty Publications

Oleate hydratase (OhyA), a flavoenzyme that catalyzes the hydration of unsaturated fatty acids, has been identified in various Bacillales organisms, including those in the Listeria, Lysinibacillus, Paenibacillus, and Staphylococcus genera. In this study, we combine structural biology with molecular and phylogenetic analyses to investigate the evolutionary dynamics of the OhyA protein family within the Bacillales order. Our evolutionary analysis reveals two distinct OhyA clades (clade I and clade II) within Bacillales that, while sharing catalytic function, exhibit significant genomic and structural differences. Our findings suggest that these OhyA clades originated from independent evolutionary processes through convergent evolution rather than gene …