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Risky Business: Liability Of Product Sellers Who Offer Safety Devices As Optional Equipment, Richard C. Ausness

Law Faculty Scholarly Articles

This Article examines the question of whether (or when) product sellers should be allowed to offer optional safety equipment without fear of being held strictly liable for selling a defectively designed product. Part II of this Article examines several approaches to risk-bearing. At one end of the spectrum, the principle of personal autonomy dictates that consumers should decide how much risk they wish to accept. On the other hand, products liability law assumes that if consumers are allowed to subject themselves to greater risk, producers will be quick to take advantage of their inability to make rational decisions about what …

Berry Preparations And Extracts, Russell J. Mumper, Jin Dai, Vincent S. Gallicchio

Pharmaceutical Sciences Faculty Patents

A method for deriving compositions having antioxidant and anti-inflammatory activity from berries is provided. The method results in a berry extract compositions having stable anthocyanin content. In one aspect, the method comprises exposing a berry to a solvent composition having a pH of from about 1 to about 4.5, and recovering a berry extract having a stabilized anthocyanin content. The berry may be a blackberry. A cryoprotectant may be added, to further stabilize the anthocyanin content. Compositions comprising the berry extract of the present invention, formulated for oral and/or topical administration, are provided also, including nutritional supplements, capsules, enteric-coated capsules, …

Forage News [2011-06], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• American Forage and Grassland Council Annual Meeting
• UK All Commodity Field Day
• Equine Exhibit Expanded for UK All Commodity Field Day
• Clover PowerPoint Released
• Kentucky Grazing School
• Alfalfa Intensive Training Seminar
• New Page added to Forage Website
• New Native Warm-Season Grasses Publications Available
• Filming Completed on Forage DVD
• Harvesting and Managing Flooded Forage
• Spraying Roundup Ready Alfalfa
• Net Wrap Cuts Losses, Saves Time
• Keys to a Profitable Forage Program

Novel Model For Multispecies Biofilms That Uses Rigid Gas-Permeable Lenses, Rebecca Peyyala, Sreenatha S. Kirakodu, Jeffrey L. Ebersole, Karen F. Novak

Center for Oral Health Research Faculty Publications

Oral biofilms comprise complex multispecies consortia aided by specific inter- and intraspecies interactions occurring among commensals and pathogenic bacterial species. Oral biofilms are primary initiating factors of periodontal disease, although complex multifactorial biological influences, including host cell responses, contribute to the individual outcome of the disease. To provide a system to study initial stages of interaction between oral biofilms and the host cells that contribute to the disease process, we developed a novel in vitro model system to grow biofilms on rigid gas-permeable contact lenses (RGPLs), which enable oxygen to permeate through the lens material. Bacterial species belonging to early- …

Chelating Compounds And Immobilized Tethered Chelators, Robert A. Yokel, Wesley R. Harris, Christopher D. Spilling, Chang-Guo Zhan

Pharmaceutical Sciences Faculty Patents

Novel di- and tripodal compounds useful as chelators, intermediates for their production and a method for treating an aqueous solution to remove trivalent metal ions are presented.

Oxidative Stress Accumulates In Adipose Tissue During Aging And Inhibits Adipogenesis, Hannes M. Findeisen, Kevin J. Pearson, Florence Gizard, Yue Zhao, Hua Qing, Karrie L Jones, Dianne Cohn, Elizabeth B. Heywood, Rafael De Cabo, Dennis Bruemmer

Saha Cardiovascular Research Center Faculty Publications

Aging constitutes a major independent risk factor for the development of type 2 diabetes and is accompanied by insulin resistance and adipose tissue dysfunction. One of the most important factors implicitly linked to aging and age-related chronic diseases is the accumulation of oxidative stress. However, the effect of increased oxidative stress on adipose tissue biology remains elusive. In this study, we demonstrate that aging in mice results in a loss of fat mass and the accumulation of oxidative stress in adipose tissue. In vitro, increased oxidative stress through glutathione depletion inhibits preadipocyte differentiation. This inhibition of adipogenesis is at …

Safety And Tolerability Of An Ovine-Derived Polyclonal Anti-Tnfα Fab Fragment (Azd9773) In Patients With Severe Sepsis, Peter E. Morris, Brian Zeno, Andrew C. Bernard, Xiangning Huang, Steven G. Simonson, Gordon R. Bernard

Surgery Presentations

Sepsis remains a significant medical problem. TNFα is a central cytokine in sepsis pathophysiology. We conducted a phase IIa trial in patients with severe sepsis to assess the safety and tolerability of an intravenously infused ovine-derived polyclonal anti-TNFα Fab fragment (AZD9773).

Forage News [2011-03], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Kentucky Alfalfa Awards
• KFGC Update
• Grazing School Offers Classroom and Field (Hands-on) Activities
• Roundup Ready® Alfalfa
• Ash Content in Hay
• Caution Advised with Grazing & Cutting Heights of Orchardgrass
• Heart of America Grazing Conference Proceedings and Photos
• Agriculture Returns as a Bright Spot in the Economic Recovery

Systematic Two-Hybrid And Comparative Proteomic Analyses Reveal Novel Yeast Pre-Mrna Splicing Factors Connected To Prp19, Liping Ren, Janel R. Mclean, Tony R. Hazbun, Stanley Fields, Craig Vander Kooi, Melanie D. Ohi, Kathleen L. Gould

Molecular and Cellular Biochemistry Faculty Publications

Prp19 is the founding member of the NineTeen Complex, or NTC, which is a spliceosomal subcomplex essential for spliceosome activation. To define Prp19 connectivity and dynamic protein interactions within the spliceosome, we systematically queried the Saccharomyces cerevisiae proteome for Prp19 WD40 domain interaction partners by two-hybrid analysis. We report that in addition to S. cerevisiae Cwc2, the splicing factor Prp17 binds directly to the Prp19 WD40 domain in a 1:1 ratio. Prp17 binds simultaneously with Cwc2 indicating that it is part of the core NTC complex. We also find that the previously uncharacterized protein Urn1 (Dre4 in Schizosaccharomyces pombe) directly …

Alfalfa Hay For Horses: Myths Vs. Reality, Laurie Lawrence

Kentucky Alfalfa and Stored Forage Conference

Does it really matter if hay has some mold in it?

Hay that is high in dust or mold can irritate the horse’s respiratory tract. Optimum athletic performance depends on a healthy respiratory tract, therefore dusty/moldy hay should never be fed to horses used (or intended for) athletic events. A chronic respiratory disease commonly called “heaves” can be aggravated by moldy and dusty hay. Horses with heaves can have so much difficulty breathing that even mild exercise is impossible. In addition, moldy hay may contain toxins that could affect the horse if they are ingested.

Horse owners should not rely …

Method Of Improving Cheese Quality, Colm D. Everard, Donal J. O'Callaghan, Colm P. O'Donnell, Colleen C. Fagan, Manuel Castillo, Frederick Alan Payne

Biosystems and Agricultural Engineering Faculty Patents

A method is provided for improving the quality of cheese produced from a curd and whey mixture. The method comprises the steps of monitoring the curd and whey mixture during syneresis processing to collect color data, comparing the color data to a predetermined standard and terminating syneresis when the color meets the predetermined standard or, alternatively, analyzing the color data obtained to generate kinetic parameters that can be used to predict the end point of syneresis to improve control of curd moisture content.

Extended Grazing And Reduced Stored Feed, Edward N. Ballard

Kentucky Grazing Conference

Feed costs represent the major cost in most livestock production systems. A recently completed analysis of 225 Standardized Performance Analysis (SPA) Beef Cow Records on herds in Illinois and Iowa showed that feed cost was the overriding factor determining profitability, explaining over 57 percent of the herd-to-herd variation. Typically the cost of supplying nutrients to ruminant livestock is much greater using harvested feedstuffs as opposed to grazing pastures or crop residues. The primary function of a grassland farm is to convert solar energy to marketable livestock products in the most efficient manner. The fewer steps between the animal product and …

Grazing Non-Traditional Forages, Jeff Mccutcheon

Kentucky Grazing Conference

In the Heart of America region we are blessed with perennial cool-season grasses and legumes as the bulk of our forage production. Efficiently taking advantage of that perennial production is the focus of most grazing operations. Occasionally there are times when the production from our cool- season grass and legume pasture is not sufficient. In Ohio, that is late summer and late fall through winter till early spring. Nontraditional forages could be used when cool season forages are not producing. Non-traditional forages can provide a large volume, of high-quality feed during specific times of the year.

Mob Grazing, High Density Grazing, Management-Intensive Grazing: What's The Difference?, Mark Kennedy

Kentucky Grazing Conference

Before we can answer that question we need to review some basic fundamentals of successful grazing management. Four goals of any sustainable grazing management strategy should be: 1) Meet the nutritional needs of livestock from standing pasture as many days as possible; 2) Optimize pasture yield, quality and persistence; 3) Maintain or enhance the natural resource base; 4) Integrate the appropriate technology and knowledge into a practical and profitable system that fits your available resources and meets your objectives. We will use these goals to compare and contrast these 2 grazing management techniques. Both techniques should be considered tools in …

How Much Pasture Do I Have And How Long Will It Feed My Cows?, S. Ray Smith

Kentucky Grazing Conference

A very common question asked by cattlemen is, “How much pasture do I have and how long will it feed my cows.” The purpose of this paper is to provide some guidelines and tools for answering this question. In pasture systems, determining the amount of pasture is much harder than in grain-based feeding systems because feed may be allocated for more than one day and feed quantity and quality is influenced by weather, fertility, stand density, and season. In addition, not all the available forage is consumed and the plants continue to grow after they are grazed. Variation in quality …

Foreword And Conference Information [2011], Garry D. Lacefield, Christi L. Forsythe

Kentucky Grazing Conference

No abstract provided.

Endophyte In Tall Fescue: Impact On Horses And Cattle, S. Ray Smith, Krista Cotton

Forage Symposium at the Kentucky Cattlemen’s Convention

Tall fescue [Lolium arundinaceum (Schreb.) Darbysh.] is an introduced cool-season perennial grass from Europe. Originally imported for regularly flooded pastures, tall fescue is now widespread across the United States due to its adaptability of a wide range of soils and climate. Kentucky 31 tall fescue is the ecotype discovered in 1931 by E.N. Fergus, which launched its popularity as a dependable, adaptable, and palatable pasture crop. In the mid-1970s, the negative effects caused by consuming tall fescue were termed fescue toxicosis. The source of fescue toxicosis was not identified until Charles Bacon first reported evidence of an endophytic fungus …

Hay For Horses: Needs And Wants, Laurie Lawrence

Forage Symposium at the Kentucky Cattlemen’s Convention

Hay producers have to satisfy two types of clients, horses and humans. Horses need clean hay that has a nutritional value that is appropriate for the requirements of the horse. Clients want hay that IS consistent, convenient and cost effective. So, in many cases the “needs” of the horse and “wants” of the human are not exactly the same.

Forages: Back To Basics, Garry D. Lacefield

Forage Symposium at the Kentucky Cattlemen’s Convention

Over the past fifteen years, we have covered many forage-related topics ranging from the species we grow through marketing our final products. Through all of these themes, we have attempted to address the “basics” in a practical way. We will continue that theme today as we deal with some very important-practical topics.

Seeds Of Compromise: A Proposal And Justification For The Partial Deregulation Of Genetically Modified Alfalfa And Sugar Beets, Whitney J. Waters

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Animal Models For Periodontal Disease, Helieh S. Oz, David A. Puleo

Center for Oral Health Research Faculty Publications

Animal models and cell cultures have contributed new knowledge in biological sciences, including periodontology. Although cultured cells can be used to study physiological processes that occur during the pathogenesis of periodontitis, the complex host response fundamentally responsible for this disease cannot be reproduced in vitro. Among the animal kingdom, rodents, rabbits, pigs, dogs, and nonhuman primates have been used to model human periodontitis, each with advantages and disadvantages. Periodontitis commonly has been induced by placing a bacterial plaque retentive ligature in the gingival sulcus around the molar teeth. In addition, alveolar bone loss has been induced by inoculation or …

Cheap Meat: How Factory Farming Is Harming Our Health, The Environment, And The Economy, R. Jason Richards, Erica L. Richards

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Summary Of Kentucky River Watershed Watch 2011 Water Sampling Results, Kentucky Water Resources Research Institute

Kentucky River Watershed Watch

No abstract provided.

Fish Oil And Barley Supplementation In Diets For Adult Dogs: Effects On Lipid And Protein Metabolism, Nutrient Digestibility, Fecal Quality, And Postprandial Glycemia, Maria Regina Cattai De Godoy

Theses and Dissertations--Animal and Food Sciences

Obesity is the most prevalent nutritional disorder encountered in small animal medicine. Problems related with obesity are the higher incidence of morbidity and mortality. Nutritional and physical activity interventions have been common strategies employed; however, they have shown low compliance rates. Because of it more attention has been given to the nutrient composition of diets. Using the canine model, three experiments were conducted to examine the effect of fish oil or barley on protein and lipid metabolism, as well as postprandial glycemia, and nutrient digestibility in mature and in young adult dogs.

In Exp. 1, seven female dogs were randomly …

Adaptation Of Lambs To An Endophyte Infected Tall Fescue Seed Diet, Rachel Ann Rickly Zinner

Theses and Dissertations--Animal and Food Sciences

Ten wether lambs were used to determine the effects of ergovaline consumption from endophyte infected tall fescue, on nutrient utilization and metabolism. Lambs were fed a diet of 23% endophyte free tall fescue seed (E-) and 77% concentrate from d -14 to -1 (adaptation phase). On d 0, five lambs were switched to an endophyte infected seed diet (E+) where they remained through d 14. Nutrient digestibilities tended to increase from adaptation through the acute (d 1 to 4) to subacute (d 10 to 14) phases when E- was fed. E+ digestibilities were highest (P < 0.05) in the acute phase. Lambs fed E+ had higher rectal temperatures in the acute (P < 0.01) and subacute phases (P < 0.05). Fecal recovery of ergovaline increased as day of collection increased in the acute and subacute phases. Lysergic acid fecal recovery increased with day of collection in the acute phase, but no effect was found in the subacute phase. Serum enzyme analyses did not indicate tissue damage from alkaloid consumption. These results demonstrate lambs try to adapt to endophyte infected fescue seed consumption through increased nutrient digestibilities and increased ergovaline and lysergic acid excretion.

Factors Affecting Skeletal Muscle Protein Synthesis In The Horse, Ashley Leigh Wagner

Theses and Dissertations--Animal and Food Sciences

Skeletal muscle protein synthesis is regulated by the mammalian target of rapamycin (mTOR) signaling pathway. The first objective was to optimize the methodological procedures for assessing mTOR signaling in horses. The response of mTOR signaling (P-Akt Ser⁴⁷³, P-S6K1 Thr³⁸⁹, P-rpS6 Ser^{235/26 & 240/244}, and P-4EBP1 Thr^37/46 by Western blotting techniques) to meal consumption was determined at three gluteal muscle biopsy depths (6, 8, and 10 cm), and the repeatability of the contralateral side at 8 cm during 5 days of repeated biopsies. There was no effect (P > 0.05) of sampling side or biopsy …

Breast Cancer Trends Among Kentucky Women, 2004-2007, Kara Ann Hagan

Theses and Dissertations--Nutrition and Food Systems

The purpose of this study is to investigate the discrepancies of female breast cancer mortality between the Appalachian and Non-Appalachian regions of Kentucky using data from the Kentucky Cancer Registry. This study identified subtype, reproductive, and regional differences in women with breast cancer in Kentucky. Among women with breast cancer living in Kentucky from 2004 to 2007, one and three live births significantly increased a woman’s risk of breast cancer mortality by 91% and 58% respectively, compared to a woman with zero live births. Progesterone receptornegative tumor status significantly increased a woman’s risk of breast cancer mortality by 64% compared …

The Healthy Monday Campaign: Health Awareness In Elementary Schools, Sheena Pravin Patel

Theses and Dissertations--Nutrition and Food Systems

Childhood obesity is a major public health concern for Americans. Many school-based health interventions and campaigns have been in place in the elementary school setting to help lower the rates of childhood obesity and to make students aware of their health. This study focuses on the implementation of the Healthy Monday campaign to fourth and fifth grade students in two Kentucky elementary schools. Particularly the focal points of the campaign consist of nutrition and physical activity. The campaign highlights two spin-off campaigns from the Healthy Monday campaign titled the Monday Mile and Meatless Monday. This study looks at the effectiveness …

Role Of The Sexual Cycle In Development Of Genotypic And Phenotypic Diversity In Gibberella Zeae, Sladana Bec

Theses and Dissertations--Plant Pathology

Gibberella zeae (anamorph Fusarium graminearum) is a homothallic ascomycete pathogen that is responsible for causing Fusarium head blight (FHB) of wheat and small grains. In addition to causing a reduction in yield, harvested grain is frequently contaminated with trichothecene mycotoxins that are harmful for human and animal health. Use of wheat varieties with resistance to FHB is an important strategy to lower its impact. In order to produce varieties with durable resistance, we must understand the origin and degree of genetic diversity present in the pathogen population. In my research, I focused my efforts on an investigation of the …

Chronic Health Conditions Of Individuals In Public Housing, Alicia A. Arnett

Theses and Dissertations--Nutrition and Food Systems

A majority of low-income individuals living in public housing today are working or receiving some kind of assistance, but still struggle to make ends meet. Previous studies show that cost and availability are barriers to healthy eating for low-income individuals. The purpose of this study was to determine relationships among nutrition habits, health status, sources of income, and food and living resources for low-income residents in public housing. The study utilizes data collected over five years on the impact of the revitalization of the families. The sample was randomly selected from residents of the housing property in a Kentucky city. …