Digital Commons Network^™

Quantifying The Effects Of Biomass Market Conditions And Policy Incentives On Economically Feasible Sites To Establish Dedicated Energy Crops, Sandhya Nepal, Marco A. Contreras, George A. Stainback, John M. Lhotka

Forestry and Natural Resources Faculty Publications

This study used a spatially-explicit model to identify the amount and spatial distribution of economically feasible sites for establishing dedicated energy crops under various market and policy scenarios. A sensitivity analysis was performed for a biomass market with different discount rates and biomass prices as well as policy scenarios including propriety tax exemption, carbon offset payments, and the inclusion of farmland for biomass production. The model was applied to a four-county study area in Kentucky representing conditions commonly found in the Ohio River Valley. Results showed that both biomass price and discount rate have a can strongly influence the amount …

A Prospective Analysis Of Factors Associated With Decreased Physical Activity In Patients With Cirrhosis Undergoing Transplant Evaluation, Anna Christina Dela Cruz, Valery Vilchez, Sooyeon Kim, Benjamin Barnes, Abhishek Ravinuthala, Anthony Zanni, Roberto Galuppo, Achuthan Sourianarayanane, Trushar Patel, Erin Colleen Maynard, Malay B. Shah, Michael F. Daily, Timothy L. Uhl, Karyn A. Esser, Roberto Gedaly

Internal Medicine Faculty Publications

BACKGROUND: Physical activity has been associated with improved recovery time after transplantation. Handgrip strength has been related to post-transplant outcomes.

AIM: To evaluate predictors of physical activity and grip strength in cirrhotic patients undergoing liver transplant evaluation.

METHODS: Single center, prospective analysis.

RESULTS: A hundred patients were evaluated (54% male, mean age 53 ± 9). Common etiologies of liver disease were non-alcoholic hepatitis (27%), hepatitis C (22%), and alcoholic liver disease (21%). Mean MELD score was 13.5. Forty one percent had a history of smoking. Ninety-three patients completed the International Physical Activity Questionnaire. The median total physical activity score of …

Residual Impact Of Previous Injury On Musculoskeletal Characteristics In Special Forces Operators, Jeffrey J. Parr, Nicholas C. Clark, John P. Abt, Julie Y. Kresta, Karen A. Keenan, Shawn F Kane, Scott M. Lephart

Physical Therapy Faculty Publications

Background: Musculoskeletal injuries are a significant burden to United States Army Special Operations Forces. The advanced tactical skill level and physical training required of Army Special Operators highlights the need to optimize musculoskeletal characteristics to reduce the likelihood of suffering a recurrent injury.

Purpose: To identify the residual impact of previous injury on musculoskeletal characteristics.

Study Design: Cross-sectional study; Level of evidence, 3.

Methods: Isokinetic strength of the knee, shoulder, and back and flexibility of the shoulder and hamstrings were assessed as part of a comprehensive human performance protocol, and self-reported musculoskeletal injury history was obtained. Subjects were stratified based …

Interaction Of Isoflavones And Endophyte-Infected Tall Fescue Seed Extract On Vasoactivity Of Bovine Mesenteric Vasculature, Yang Jia, David L. Harmon, Michael D. Flythe, James L. Klotz

Animal and Food Sciences Faculty Publications

It was hypothesized that isoflavones may attenuate ergot alkaloid-induced vasoconstriction and possibly alleviate diminished contractility of vasculature after exposure to ergot alkaloids. The objective of this study was to determine if prior incubation of bovine mesenteric vasculature with the isoflavones formononetin (F), biochanin A (B), or an ergovaline-containing tall fescue seed extract (EXT) and their combinations affect ergotamine (ERT)-induced contractility. Multiple segments of mesenteric artery and vein supporting the ileal flange of the small intestine were collected from Angus heifers at slaughter (n = 5, bodyweight = 639 ± 39 kg). Duplicates of each vessel …

Cd151-Α3Β1 Integrin Complexes Are Prognostic Markers Of Glioblastoma And Cooperate With Egfr To Drive Tumor Cell Motility And Invasion, Pengcheng Zhou, Sonia Erfani, Zeyi Liu, Changhe Jia, Yecang Chen, Bingwei Xu, Xinyu Deng, Jose E. Alfáro, Li Chen, Dana L. Napier, Michael Lu, Jian-An Huang, Chunming Liu, Olivier Thibault, Rosalind Segal, Binhua P. Zhou, Natasha Kyprianou, Craig Horbinski, Xiuwei H. Yang

Pharmacology and Nutritional Sciences Faculty Publications

Glioblastoma, one of the most aggressive forms of brain cancer, is featured by high tumor cell motility and invasiveness, which not only fuel tumor infiltration, but also enable escape from surgical or other clinical interventions. Thus, better understanding of how these malignant traits are controlled will be key to the discovery of novel biomarkers and therapies against this deadly disease. Tetraspanin CD151 and its associated α3β1 integrin have been implicated in facilitating tumor progression across multiple cancer types. How these adhesion molecules are involved in the progression of glioblastoma, however, remains largely unclear. Here, we examined an in-house tissue microarray-based …

Thoughts On Why I Love School, Anna Rothert

Kaleidoscope

No abstract provided.

Women With Disabilities: Reproductive Care And Women’S Health, Stephanie Stockburger, Hatim A. Omar

Pediatrics Faculty Publications

Children, adolescents, and women with disabilities experience the same sexual development, pubertal changes, concerns, and desire to reproduce as their typically developing counterparts. However, society has tended to stigmatize women with disabilities as “asexual” and ignore this aspect of their health care. These women are less likely to receive gynecological exams, contraception, and evaluation of sexual dysfunction. Unfortunately, having a disability places women at risk for sexual exploitation and abuse as well as sexually transmitted infections. Therefore, reproductive health care for these women is imperative. A number of barriers to receiving reproductive care exist. However, with proper education and knowledge …

Producer’S Guide To Pasture-Based Beef Finishing, Gregory S. Halich, Jeff Lehmkuhler, Gregg Rentfrow, Fred Martz, S. Ray Smith, Lee Meyer

Agriculture and Natural Resources Publications

Beef cattle were routinely finished locally in Kentucky and other parts of the upper south before the 1950s, primarily on pasture with some grain or by-products from distilleries and grain processing mills. Cattle were typically born, raised, and finished on the same farm then sent to a local butcher where the meat was sold in nearby communities and cities. After the Second World War grain and transportation costs decreased dramatically and supermarket chains that required a large, steady supply channel were established. The combined effect of these changes made finishing in large centralized locations more economical. Over the next couple …

Uk Ag Equine Programs 2016 Calendar: A 12-Month Planning Calendar For The Care And Use Of Your Horses, Jason R. Philips, Glenn Mackie, Don Sorrell, Nicholas L. Carter, Paula A. Jerrell, Brian Newman, Daniel O. Wilson, Christopher Jeffcoat, Karen Douglas, Katheryn Cerny, Fernanda Camargo, Robert Coleman, Essie Rodgers, Jim Smith

Agriculture and Natural Resources Publications

The information in this calendar is provided to aid owners in planning for the care and use of their horses for the whole year.

When necessary, information is discussed in the month prior to application to allow horse owners adequate time to plan for activities such as weed control, soil and feed testing, vaccinations, etc.

Contact your local veterinarian for health-related issues and your county extension ANR, 4-H, or FCS agent for further information. County office phone numbers are listed at the end of the calendar.

Moving People Off Public Assistance Programs Through Education, Christopher R. Bollinger

Issue Brief on Topics Affecting Kentucky’s Economy

Two of the largest federal transfer programs are the Supplemental Nutrition Assistance Program (SNAP) and Supplemental Security Income (SSI). Federal expenditures on SNAP exceeded $74 billion in 2014, and SSI exceeded $3 billion. While these programs provide families in distress with important support, ideally we desire that Kentucky families would not require this kind of assistance. In 2014, over 800,000 Kentuckians received SNAP assistance each month while over 190,000 received SSI. This brief examines the relationship between participation in these programs and educational attainment for Kentuckians. We find that education is highly related to participation and that those with higher …

Nhash: Randomized N-Gram Hashing For Distributed Generation Of Validatable Unique Study Identifiers In Multicenter Research, Guo-Qiang Zhang, Shiqiang Tao, Guangming Xing, Jeno Mozes, Bilal Zonjy, Samden D. Lhatoo, Licong Cui

Institute for Biomedical Informatics Faculty Publications

BACKGROUND: A unique study identifier serves as a key for linking research data about a study subject without revealing protected health information in the identifier. While sufficient for single-site and limited-scale studies, the use of common unique study identifiers has several drawbacks for large multicenter studies, where thousands of research participants may be recruited from multiple sites. An important property of study identifiers is error tolerance (or validatable), in that inadvertent editing mistakes during their transmission and use will most likely result in invalid study identifiers.

OBJECTIVE: This paper introduces a novel method called "Randomized N-gram Hashing (NHash)," …

Evaluating The Use Of Tree Shelters For Direct Seeding Of Castanea On A Surface Mine In Appalachia, Christopher Barton, Jarrod Miller, Kenton L. Sena, Patrick Angel, Michael French

Forestry and Natural Resources Faculty Publications

American chestnut (Castanea dentata), once a primary constituent of the eastern hardwood forest ecosystem, was nearly extirpated from the forest canopy by the accidental introduction of chestnut blight (Cryphonectria parasitica). An intensive breeding program has sought to breed blight resistance from Chinese chestnut into American chestnuts, while maintaining as much of the desirable American chestnut phenotypes as possible. Previous studies suggest that these blight resistant American chestnuts, termed “restoration chestnuts”, are capable of thriving on reclaimed surface mines. We direct seeded pure Chinese, pure American, and three backcross lines into brown sandstone minesoil on a mine …

Effects Of Adipocyte Aryl Hydrocarbon Receptor Deficiency On Pcb-Induced Disruption Of Glucose Homeostasis In Lean And Obese Mice, Nicki A. Baker, Robin Shoemaker, Victoria English, Nika Larian, Manjula Sunkara, Andrew J. Morris, Mary Walker, Frederique Yiannikouris, Lisa A. Cassis

Saha Cardiovascular Research Center Faculty Publications

BACKGROUND: Coplanar polychlorinated biphenyls (PCBs) promote adipocyte inflammation and impair glucose homeostasis in lean mice. The diabetes-promoting effects of lipophilic PCBs have been observed only during weight loss in obese mice. The molecular mechanisms linking PCB exposures to impaired glucose metabolism are unclear.

OBJECTIVES: In this study we tested the hypothesis that coplanar PCBs act at adipocyte aryl hydrocarbon receptors (AhRs) to promote adipose inflammation and impair glucose homeostasis in lean mice and in obese mice during weight loss.

METHODS AND RESULTS: PCB-77 administration impaired glucose and insulin tolerance in LF (low fat diet)-fed control (AhR^fl/fl) mice …

The Niehs Superfund Research Program: 25 Years Of Translational Research For Public Health, Philip J Landrigan, Robert O. Wright, Jose F. Cordero, David L. Eaton, Bernard D. Goldstein, Bernhard Hennig, Raina M. Maier, David M. Ozonoff, Martyn T. Smith, Robert H. Tukey

Animal and Food Sciences Faculty Publications

BACKGROUND: The Superfund Research Program (SRP) is an academically based, multidisciplinary, translational research program that for 25 years has sought scientific solutions to health and environmental problems associated with hazardous waste sites. SRP is coordinated by the National Institute of Environmental Health Sciences (NIEHS). It supports multi-project grants, undergraduate and postdoctoral training programs, individual research grants, and Small Business Innovation Research (SBIR) and Technology Transfer Research (STTR) grants.

RESULTS: SRP has had many successes: discovery of arsenic's toxicity to the developing human central nervous system; documentation of benzene toxicity to hematologic progenitor cells in human bone marrow; development …

A Novel C-Terminal Cib2 (Calcium And Integrin Binding Protein 2) Mutation Associated With Non-Syndromic Hearing Loss In A Hispanic Family, Kunjan Patel, Arnaud P. Giese, J. M. Grossheim, Rashima S. Hegde, Maria Delio, Joy Samanich, Saima Riazuddin, Gregory I. Frolenkov, Jinlu Cai, Zubair M. Ahmed, Bernice E. Morrow

Physiology Faculty Publications

Hearing loss is a complex disorder caused by both genetic and environmental factors. Previously, mutations in CIB2 have been identified as a common cause of genetic hearing loss in Pakistani and Turkish populations. Here we report a novel (c.556C>T; p.(Arg186Trp)) transition mutation in the CIB2 gene identified through whole exome sequencing (WES) in a Caribbean Hispanic family with non-syndromic hearing loss. CIB2 belongs to the family of calcium-and integrin-binding (CIB) proteins. The carboxy-termini of CIB proteins are associated with calcium binding and intracellular signaling. The p.(Arg186Trp) mutation is localized within predicted type II PDZ binding ligand at the carboxy …

Patient-Specific Variations In Biomarkers Across Gingivitis And Periodontitis, Radhakrishnan Nagarajan, Craig S. Miller, Dolph Dawson, Mohanad Al-Sabbagh, J. L. Ebersole

Biostatistics Faculty Publications

This study investigates the use of saliva, as an emerging diagnostic fluid in conjunction with classification techniques to discern biological heterogeneity in clinically labelled gingivitis and periodontitis subjects (80 subjects; 40/group) A battery of classification techniques were investigated as traditional single classifier systems as well as within a novel selective voting ensemble classification approach (SVA) framework. Unlike traditional single classifiers, SVA is shown to reveal patient-specific variations within disease groups, which may be important for identifying proclivity to disease progression or disease stability. Salivary expression profiles of IL-1ß, IL-6, MMP-8, and MIP-1α from 80 patients were analyzed using four classification …

Catatonia In Older Adult Individuals With Intellectual Disabilities, Megan White, Edward Maxwell, Warren E. Milteer, Jose De Leon

Psychiatry Faculty Publications

Catatonia has been described in children with intellectual disabilities (IDs). These are the first three published cases of catatonia in adults older than 50 years of age with IDs. They were followed using the KANNER scale and, in one case, creatinine phosphokinase (CPK) monitoring. Case 1 is a 67-year-old Caucasian who probably had been having intermittent episodes of undiagnosed catatonia withdrawal for many years. His episodes of agitation and withdrawal behavior responded to lorazepam up to 8 mg/day. Case 2 is a 63-year-old Caucasian male who had probably had undiagnosed catatonic episodes since age 25. An agitation episode that rated …

Workforce Fitness: Description, Contextual Issues, And Implications For Public Health, Nicolaas P. Pronk

Frontiers in Public Health Services and Systems Research

Workforce fitness matters for the prevention of premature death, chronic diseases, productivity loss, excess medical care costs, loss of income or family earnings, and other social and economic concerns. Yet fitness levels appear to be relatively low and declining. Over the past half century obesity has doubled, physical activity levels are below par, and cardiorespiratory fitness often does not meet minimally acceptable job standards. During this time, daily occupational energy expenditure has decreased by more than 100 calories. It is recommended for employers to consider best practices and design workplace wellness programs accordingly. Regulations that protect and promote worker health, …

Use Of Facebook By Local Health Departments: Usage, Public Health Themes, And Maintenance, Rakhi Trivedi, Gulzar H. Shah, Ankit Bangar

Frontiers in Public Health Services and Systems Research

Background: Recent research shows that social media offer unprecedented opportunities for communications with stakeholders in public health and other industries.

Purpose: This study examines the manner in which U.S. local health departments (LHDs) use Facebook. Public health program themes discussed on Facebook profiles of LHDs were analyzed and ranked by the frequency of mentions on Facebook.

Methods: LHDs included in the study were those indicating use of Facebook in the 2010 National Profile of Local Health Departments. Using the list from the profile study, the primary data from LHDs’ public Facebook profiles were collected over a period of 4 months. …

Trends In Health Care Delivery Systems: Implications For Cancer Prevention And Control, Glen P. Mays

Health Management and Policy Presentations

The Affordable Care Act and larger economic forces are leading both health care providers and public health agencies to renegotiate their roles and responsibilities within the U.S. health system. This session reviews major changes occurring in both health care and public health delivery systems, with a focus on the implications for cancer prevention and control. The information infrastructure created by cancer registries and other health information systems are increasingly important for enabling greater coordination, alignment and accountability within the nation's changing delivery systems.

Showcase Of Scholars, Uk Office Of Undergraduate Research

Kaleidoscope

No abstract provided.

The Dietary Habits And Nutrition Education Levels Of Parents Of Pre-School Children At A Community Head Start Program, Lisa Renee Keys

Kaleidoscope

The health of America’s youth is jeopardized as obesity, often beginning in childhood, becomes a major epidemic. Parents have exceptional influence on their children, especially nutritionally, which impacts how their children grow and develop. Parents with minimal nutrition education and who do not practice healthy eating habits may unintentionally influence their children in practices that could lead to nutrition-related disease and/or obesity. This research evaluated the dietary habits and nutrition knowledge of parents of preschoolers at a community Head Start program in Lexington, KY, which served a high percentage of Hispanic children. The parents were given a survey evaluating their …

Complete Issue Of Volume 5

Kaleidoscope

No abstract provided.

Front Matter

Kaleidoscope

No abstract provided.

From The Editor's Viewpoint, Robert S. Tannenbaum

Kaleidoscope

No abstract provided.

S.P.U.R., Uk Office Of Undergraduate Research

Kaleidoscope

No abstract provided.

Showcase Of Undergraduate Scholars, Uk Office Of Undergraduate Research

Kaleidoscope

No abstract provided.

Prehistoric Drawings In Mammoth Cave, Logan Kistler

Kaleidoscope

During a recent Earthwatch Institute survey of archaeological remains in Mammoth Cave, a project was begun to find and record prehistoric images on the cave walls. I chose to analyze petroglyphs and pictographs on three panels in Main Cave. This article offers a hypothesis for the circumstances surrounding the rock art’s production: the geometric and anthropomorphic figures in Mammoth Cave are representative of a series of visual percepts experienced cross-culturally and caused by various conditions — including sensory deprivation, fatigue, and psychoactive drug use — acting on the ocular anatomy and nervous system. That is, the glyphs might be visual …

Mir-29/Hsp47 In Ecm Network, Ren Xu

Markey Cancer Center Faculty Publications

No abstract provided.

Summer Research And Creativity Grants, Uk Office Of Undergraduate Research

Kaleidoscope

The abstracts in this section were submitted by students who received Research and Creativity Awards for the summer of 2008. Many are not final reports, because the projects were still in process when the submissions were due. Rather, they are progress reports. However, these abstracts provide a clear and wonderfully diverse picture of the broad range of scholarly activities being undertaken by undergraduates at the University of Kentucky.