Digital Commons Network^™

The Context-Dependent Impact Of Integrin-Associated Cd151 And Other Tetraspanins On Cancer Development And Progression: A Class Of Versatile Mediators Of Cellular Function And Signaling, Tumorigenesis And Metastasis, Sonia F. Erfani, Hui Hua, Yueyin Pan, Binhua P. Zhou, Xiuwei H. Yang

Molecular and Cellular Biochemistry Faculty Publications

As a family of integral membrane proteins, tetraspanins have been functionally linked to a wide spectrum of human cancers, ranging from breast, colon, lung, ovarian, prostate, and skin carcinomas to glioblastoma. CD151 is one such prominent member of the tetraspanin family recently suggested to mediate tumor development, growth, and progression in oncogenic context- and cell lineage-dependent manners. In the current review, we summarize recent advances in mechanistic understanding of the function and signaling of integrin-associated CD151 and other tetraspanins in multiple cancer types. We also highlight emerging genetic and epigenetic evidence on the intrinsic links between tetraspanins, the epithelial-mesenchymal transition …

Insects Provide Unique Systems To Investigate How Early-Life Experience Alters The Brain And Behavior, Rebecca R. Westwick, Clare C. Rittschof

Entomology Faculty Publications

Early-life experiences have strong and long-lasting consequences for behavior in a surprising diversity of animals. Determining which environmental inputs cause behavioral change, how this information becomes neurobiologically encoded, and the functional consequences of these changes remain fundamental puzzles relevant to diverse fields from evolutionary biology to the health sciences. Here we explore how insects provide unique opportunities for comparative study of developmental behavioral plasticity. Insects have sophisticated behavior and cognitive abilities, and they are frequently studied in their natural environments, which provides an ecological and adaptive perspective that is often more limited in lab-based vertebrate models. A range of cues, …

Dynamic Changes Of Tannin Contents In Five Varieties Of Tropical Leguminous Forages At Different Growth Stages And Their Responses To Fertilization, Y. B. Huang, Z. T. Chen, E. Chen, B. Q. Weng, J. G. Zheng

IGC Proceedings (1977-2023)

No abstract provided.

Study On The Adaptability Of Brachiaria Spp. In Subtropical Region Of Fujian, X. H. Luo, Y. S. Lin, Z. Y. Ying

IGC Proceedings (1977-2023)

No abstract provided.

Domestication Of Leymus Paboanus (Claus) Pilger, Dusu Wen, Hailian Sun, Chunli Bai, A. Lata

IGC Proceedings (1977-2023)

No abstract provided.

Antibiotic Prescription Practices And Opinions Regarding Antimicrobial Resistance Among Veterinarians In Kentucky, Usa, Agricola Odoi, Ronita Samuels, Craig N. Carter, Jackie Smith

Veterinary Diagnostic Laboratory Faculty Publications

Background
Inappropriate antimicrobial use (AMU) is a global concern. Opinions of veterinarians regarding AMU and its role in the development of antimicrobial resistance (AMR) may influence their prescription practices. It is important to understand these opinions, prescription practices and their potential impact on the development of AMR in order to guide efforts to curb the problem. Therefore, the objective of this study was to investigate the antimicrobial prescription practices and opinions of veterinarians in Kentucky regarding AMU and AMR.

Methods
This cross-sectional study used a 30-question survey questionnaire administered to veterinarians who were members of the Kentucky Veterinary Medical Association. …

Evaluation Of The Performance Of Seventeen Varieties Of Alfalfa (Medicago Sativa L), Yan Sun, Qingchuan Yang

IGC Proceedings (1977-2023)

No abstract provided.

Effects Of Sowing Methods And Seeding Rates On Chemical Composition Of Tephrosia Bracteolata, Olufemi S. Onifade, T. A. Amole, Alaba O. Jolaosho, O. M. Arigbede, Jimoh A. Olanite, U. Y. Anele, A. M. Oyeladun

IGC Proceedings (1977-2023)

No abstract provided.

Vitamin D Promotes Skeletal Muscle Regeneration And Mitochondrial Health, Christine M. Latham, Camille R. Brightwell, Alexander R. Keeble, Brooke D. Munson, Nicholas T. Thomas, Alyaa M. Zagzoog, Christopher S. Fry, Jean L. Fry

Athletic Training and Clinical Nutrition Faculty Publications

Vitamin D is an essential nutrient for the maintenance of skeletal muscle and bone health. The vitamin D receptor (VDR) is present in muscle, as is CYP27B1, the enzyme that hydroxylates 25(OH)D to its active form, 1,25(OH)D. Furthermore, mounting evidence suggests that vitamin D may play an important role during muscle damage and regeneration. Muscle damage is characterized by compromised muscle fiber architecture, disruption of contractile protein integrity, and mitochondrial dysfunction. Muscle regeneration is a complex process that involves restoration of mitochondrial function and activation of satellite cells (SC), the resident skeletal muscle stem cells. VDR expression is strongly upregulated …

Discovering And Enforcing A Human Right To Environmental Protection, Mélanne Andromecca Civic

Journal of Natural Resources & Environmental Law

No abstract provided.

Chromosome Xq23 Is Associated With Lower Atherogenic Lipid Concentrations And Favorable Cardiometabolic Indices, Pradeep Natarajan, Akhil Pampana, Sarah E. Graham, Sanni E. Ruotsalainen, James A. Perry, Paul S. De Vries, Jai G. Broome, James P. Pirruccello, Michael C. Honigberg, Krishna Aragam, Brooke Wolford, Jennifer A. Brody, Lucinda Antonacci-Fulton, Moscati Arden, Stella Aslibekyan, Themistocles L. Assimes, Christie M. Ballantyne, Lawrence F. Bielak, Joshua C. Bis, Brian E. Cade, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in large sample sizes. We now analyze genetic and blood lipid data in a high-coverage whole X chromosome sequencing study of 65,322 multi-ancestry participants and perform replication among 456,893 European participants. Common alleles on chromosome Xq23 are strongly associated with reduced total cholesterol, LDL cholesterol, and triglycerides (min P = 8.5 × 10⁻⁷²), with similar effects for males and females. Chromosome Xq23 lipid-lowering alleles are associated with reduced odds for CHD among 42,545 …

Effects Of Selection For Seed Size On Grazing‐Type Population Of An Inter‐Specific Hybrid (Pennisetum Purpureum × P. Glaucum), R. Usberti, J. A. Usberti Jr., P. B. Alcantara, A. T. Tsuhako

IGC Proceedings (1977-2023)

No abstract provided.

Brachiaria Hybrids: Their Origin And Potential Forage Use, Esteban A. Pizarro, Michael D. Hare, John W. Miles

IGC Proceedings (1977-2023)

No abstract provided.

Fat And Carbohydrate Interact To Potentiate Food Reward In Healthy Weight But Not In Overweight Or Obesity, Emily E. Perszyk, Zach Hutelin, Jessica Trinh, Arsene Kanyamibwa, Sophie Fromm, Xue S. Davis, Kathryn M. Wall, Kyle D. Flack, Alexandra G. Difeliceantonio, Dana M. Small

Dietetics and Human Nutrition Faculty Publications

Prior work suggests that actual, but not estimated, energy density drives the reinforcing value of food and that energy from fat and carbohydrate can interact to potentiate reward. Here we sought to replicate these findings in an American sample and to determine if the effects are influenced by body mass index (BMI). Thirty participants with healthy weight (HW; BMI 21.92 ± 1.77; M ± SD) and 30 participants with overweight/obesity (OW/OB; BMI 29.42 ± 4.44) rated pictures of common American snacks in 120-kcal portions for liking, familiarity, frequency of consumption, expected satiety, healthiness, energy content, energy density, and price. Participants …

Seed Production And Seed Quality Of Brachiaria Hybrids (Mulato And Mulato Ii) At Different Sites Of Thailand, Chaisang Phaikaew, Pimpaporn Pholsen, Ganda Nakamanee, Weerapon Poonpipat

IGC Proceedings (1977-2023)

No abstract provided.

Tolerance To Copper Stress In Elephantgrass (Pennisetum Purpureum) Under Soil Culture, Xinghua Liu, Yixing Shen, Yujiao He, Chenglong Ding, Qingsheng Cai

IGC Proceedings (1977-2023)

No abstract provided.

Genetic Diversity Of Medicago Ruthenica In Inner Mongolia On Using Ssr Markers, Hongyan Li, Zhiyong Li, Fugui Mi, Xinxiong Lu, Hongmei Ning, Wengui Shi, Xingyou Li

IGC Proceedings (1977-2023)

No abstract provided.

Factors Influencing Adoption Of Cattle Excreta Management Practices For Improved Elephant Grass (Pennisetum Purpureum) Production By Smallholder Dairy Farmers, Fred Kabi, F. B. Bareeba

IGC Proceedings (1977-2023)

No abstract provided.

Vigna Luteola And Vigna Longifolia: The Potential Of Local Ecotypes From Humid Rangelands Of Southern Brazil, Hermes Benedete, Abdon Schmitt, Fabio Martins, Alden Nacimanto

IGC Proceedings (1977-2023)

No abstract provided.

Comparison Of Productivity Among Alfalfa Varieties With Different Fall Dormancy, Chengzhang Wang, Xuebing Yan, Yuxia Guo, Yongge Gao, Yanhua Wang

IGC Proceedings (1977-2023)

No abstract provided.

Adaptability Of Cleistogenes Songorica To Drought Stress, Tao Qu, Zhibiao Nan

IGC Proceedings (1977-2023)

No abstract provided.

Study On Determinate And Indeterminate Growth Habit Of Alfalfa, Jinhua Li, Xinshi Lu, Jishan Chen

IGC Proceedings (1977-2023)

No abstract provided.

Growth Response Of Alfalfa Cultivars And Change In Soil Nutrient Availability By Lime Application In Acid Soils, Yanjun Guo, Jianguo Huang, Jianguo Han

IGC Proceedings (1977-2023)

No abstract provided.

Alternative Community Nutrition Experiential Learning Opportunities For Dietetic Interns During Covid-19, Courtney T. Luecking, Elizabeth Combs, Heather Norman-Burgdolf

Dietetics and Human Nutrition Faculty Publications

In response to the COVID-19 pandemic, collaboration among faculty in the Department of Dietetics and Human Nutrition at the University of Kentucky yielded two, four-week virtual experiential learning opportunities with Cooperative Extension for 19 dietetic interns. Remote experiences focused on development of new programming regarding the role of nutrition in the prevention/management of the most prevalent chronic diseases affecting Kentuckians and translating an existing social marketing program that promotes quality family time through preparation of nutritious, affordable home-cooked meals. Weekly assignments took ~10 hours, included individual and groupwork, and came together to create program packages encompassing commonly used products (e.g., …

Line Hops And Side Hold Rotation Tests Load Both Anterior And Posterior Shoulder: A Biomechanical Study, Margie K. Olds, Nicole Lemaster, Kelsey Picha, Cody Walker, Nicholas R. Heebner, Timothy L. Uhl

Sports Medicine Research Institute Faculty Publications

Background: Clinical tests should replicate the stressful positions encountered during sport participation. Evaluating the kinetic and electromyographical demands of clinical tests enables clinicians to choose appropriate tests for specific sports.

Purpose: To describe the shoulder forces and muscle activation levels during closed chain functional tests of Line Hops (LH) and Side Hold Rotation (SHR).

Study Design: Descriptive biomechanical study.

Methods: Ten asymptomatic participants were examined in a university laboratory. Two functional tests were evaluated using three-dimensional video analysis and electromyography to measure shoulder forces, moments, and muscular activity levels.

Results: SHR produced a peak average posterior translation force of 4.84 …

Coconut Inflorescence Sap Enhances Exercise Performance And Plasma Antioxidant Status In Young Active Men, Ashish Joseph, Svenia P. Jose, Bintu T. Kalyan, Renny R. Mammen, I. M. Krishnakumar, Bradley S. Fleenor, Ratheesh Mohan

Kinesiology and Health Promotion Faculty Publications

Purpose
Nutrition has been increasingly recognized as a key component to optimal sports performance. Though several botanical agents have been reported to possess ergogenic potential, there exists a great interest for tasty and safe natural substances as performance boosters. In the present contribution, the ergogenic potential of a novel powder form of coconut inflorescence sap (CSP) was investigated for the first time.

Method
Out of the fourteen participants recruited, twelve recreationally active men completed the single-blinded, placebo-controlled, crossover study for 8 weeks. Running based anaerobic sprint test (RAST) and 2.4 km running test were performed as anaerobic and aerobic tests, …

The Study On The Mathematics Model Of Forage Type Mulberry High‐Output Cultivation And Optimizing Plan, Shuangyin Sun

IGC Proceedings (1977-2023)

No abstract provided.

Dendrolobium Spp. — A Source Of Tropical Multipurpose Legumes, R. Schultze‐Kraft, M. Peters, L. H. Franco, B. Hincapié

IGC Proceedings (1977-2023)

No abstract provided.

An Inactivated Bacterium (Paraprobiotic) Expressing Bacillus Thuringiensis Cry5b As A Therapeutic For Ascaris And Parascaris Spp. Infections In Large Animals, Joseph F. Urban, Martin K. Nielsen, David Gazzola, Yue Xie, Ethiopia Beshah, Yan Hu, Hanchen Li, Florentina Rus, Kelly Flanagan, Austin Draper, Sridhar Vakalapudi, Robert W. Li, Gary R. Ostroff, Raffi V. Aroian

Maxwell H. Gluck Equine Research Center Faculty Publications

Ascaris and Parascaris are important parasites in the family Ascarididae, large, ubiquitous intestinal-dwelling nematodes infecting all classes of vertebrates. Parasitic nematode drug resistance in veterinary medicine and drug recalcitrance in human medicine are increasing worldwide, with few if any new therapeutic classes on the horizon. Some of these parasites are zoonotic, e.g., Ascaris is passed from humans to pigs and vice versa. The development of new therapies against this family of parasites would have major implications for both human and livestock health. Here we tested the therapeutic ability of a paraprobiotic or dead probiotic that expresses the Bacillus …

Association Of Trees And Crops To Increase Seasonal Food Availability In The Republic Of Haity, F. Massolino, Andrea Pardini

IGC Proceedings (1977-2023)

No abstract provided.