Digital Commons Network^™

Changes In Midwestern Fly Ash Ii. Air Classification, Magnetic Separation And The Pozzolanic Characteristics Of The Ash, Anne Oberlink, Sydney Dendekker, Haley Johnson, Thomas Robl

World of Coal Ash Proceedings

Changes in Midwestern Fly Ash II. Air Classification, Magnetic Separation and the Pozzolanic Characteristics of the Ash Authors Ms. Anne Oberlink - United States - University of Kentucky Center for Applied Energy Research Ms. Sydney Dendekker - United States - University of Kentucky Center for Applied Energy Research Ms. Haley Johnson - United States - University of Kentucky Center for Applied Energy Research Dr. Thomas Robl - United States - University of Kentucky Center for Applied Energy Research Dr. Bob Jewell - United States - University of Kentucky Center for Applied Energy Research Abstract Six current production fly ashes from …

Successful Piloting Of Discrete Iss At A Ccr Impoundment, George Little, Paul Lear, Tim Silar, Richard Chapman

World of Coal Ash Proceedings

Successful Piloting of Discrete ISS at a CCR Impoundment Authors Mr. George Little - United States - Forgen Dr. Paul Lear - United States - Lear Environmental Consulting Mr. Tim Silar - United States - Silar Services Mr. Richard Chapman - United States - Forgen Mr. John Magee - United States - Silar Services Mr. Ambaresh Tijare - United States - Forgen Mr. David Miller - United States - Forgen Abstract Discrete ISS involves targeted stabilization treatment in a discrete treatment zone. Rather than treating overburden, the mixing auger injects water and/or air as a drilling fluid until the top …

Coal Ash Constituents And Treatment Options, Christine Harris, Rob Orlando

World of Coal Ash Proceedings

Coal Ash Constituents and Treatment Options Authors Mrs. Christine Harris - United States - Groundwater Treatment and Technology, LLC (GWTT) Mr. Rob Orlando - United States - Groundwater Treatment and Technology, LLC (GWTT) Abstract This presentation will open with a review of the information required to design a water treatment system to meet discharge requirements, including how the constituents may change as the ash is dewatered. Attendees will then be invited to spin the wheel of constituents. Based on water samples results, there are many potential constituents in coal ash. This presentation will cover the eight (8) most common constituents …

Wicking Wells - A Novel Method To Remediate Dissolved Solids In Groundwater, Shane Mcdonald

World of Coal Ash Proceedings

Wicking Wells, a new novel method to remediate dissolved solids in groundwater Authors Mr. Shane McDonald - United States - HDR Abstract A newly patented method for removing total dissolved solids (TDS) from groundwater has been developed at HDR. This method, called ‘wicking wells’, uses capillary media positioned to be just touching the water table in a purpose-designed well. The purpose-designed well taps the most contaminated groundwater, focusing on the highest TDS. The capillary media wicks the water to above the water table where heated dry air is passed across the media to evaporate the water. The produced water vapor …

Paper_Wicking Wells, A New Novel Method To Remediate Dissolved Solids In Groundwater, Shane Mcdonald

World of Coal Ash Proceedings

A newly patented method for removing total dissolved solids (TDS) from groundwater has been developed at HDR. This method, called ‘wicking wells’, uses capillary media positioned to be just touching the water table in a purpose-designed well. The well taps the most contaminated groundwater, focusing on the highest TDS. The capillary media wicks the water to above the water table where heated dry air is passed across the media to evaporate the water. The newly-moistened air is exhausted to the atmosphere and any dissolved solids will precipitate and be captured on the capillary media. In this way, the most onerous …

Impoundment Closure Using Discrete In-Situ Solidification Site Update, Tim Silar, John Magee

World of Coal Ash Proceedings

Impoundment Closure Using Discrete In-situ Solidification – Site Update Authors Mr. Tim Silar - United States - Silar Services Mr. John Magee - United States - Silar Services Abstract In accordance with USEPA guidance, the protection of groundwater and/or surface water is driving CCP impoundment closures. This presentation will describe an impoundment closure where discrete in-situ solidification is being implemented to achieve USEPA’s requirement of controlling the vertical and horizontal movement of groundwater. The technology, which has gained regulatory approval, will hydraulically isolate the ash from the groundwater by constructing a hydraulic barrier at the bottom of the impoundment using …

Paper_Coal Combustion Residuals – Productive, Reliable, And Sustainable Approaches To Remediation, Dave Donahue, Faizan Chowdhury, Max Swoboda

World of Coal Ash Proceedings

Coal combustion residuals (CCRs) are the second-largest waste material in the U.S., behind household garbage. As such, it is vital that CCRs are correctly managed to prevent environmental damage and safeguard human and animal health. With almost 5 billion tons of coal ash stored by utilities at more than 1,000 sites across the U.S. – whether in ponds as a wet slurry or in landfills as dry powder – preventing leaks into waterways or the air is an industry priority. Every day, Xylem’s experts help power plant operators safely manage CCRs by combining decades of on-the-ground expertise with cutting-edge technology …

Removal Of Selenium From Difficult-To-Treat Wastewaters Using An Innovative Reductive-Adsorptive Media, Patrick Mckeown, Madan Tandukar, Steve Woodard, Mike Nickelsen

World of Coal Ash Proceedings

Removal of Selenium from Difficult-to-treat Wastewaters Using an Innovative Reductive-adsorptive Media Authors Mr. Patrick McKeown - United States - ECT2 Dr. Madan Tandukar - United States - ECT2 Dr. Steve Woodard - United States - ECT2 Mr. Mike Nickelsen - United States - ECT2 Abstract Selenium is one of the more difficult-to-treat emerged contaminants, and is mostly prevalent in mining and power wastewater. In water and wastewater, selenium generally exists as soluble oxyanions, selenite (SeO32−) and selenate (SeO42−). Out of these, selenate is the more mobile and prevalent species, which also is more difficult to remove. With increasing focus on …

Best Practices In Implementing, Mark Rokoff

World of Coal Ash Proceedings

CASE STUDY: BEST PRACTICES IN IMPLEMENTING THE FACILITY EVALUATION REPORT (PER THE LEGACY CCR SI RULE) Authors Mr. Mark Rokoff - United States - Burns & McDonnell Abstract Corresponding to the proposed Legacy CCR Surface Impoundment Rules (Legacy Rule) published on May 18, 2023, Owner/Operators must initiate the efforts for compliance by first understanding the areas where CCR has accumulated within a plant’s facility outside of a regulated CCR unit. More specifically, one of the first, new tasks to comply with the proposed rule is to develop a Facility Evaluation Report (FER) in which the presence/absence of a CCR management …

Changes In The Nature Of Midwestern Fly Ash Over The Past Two Decades- I. Chemistry, Mineralogy And Beneficiation Potential, Bob Jewell, Anne Oberlink, Thomas Robl

World of Coal Ash Proceedings

Changes in the Nature of Midwestern Fly Ash Over the Past Two Decades: I. Chemistry, Mineralogy, and Beneficial Potential Authors Dr. Bob Jewell - United States - University of Kentucky Center for Applied Energy Research Ms. Anne Oberlink - United States - University of Kentucky Center for Applied Energy Research Dr. Thomas Robl - United States - University of Kentucky Center for Applied Energy Research Abstract Environmental regulations regarding coal combustion have become more stringent over time. The percentage of plants equipped with scrubbers in Kentucky increased from ~4% in 1978 to ~48% in 1997 to the point where flu …

Novel Mining Materials Based On Coal Solid Waste, Dong Zhang, Yang Dong, Jinder Jow, Si-Yu Gong

World of Coal Ash Proceedings

A series of fly ash-based mining materials have been developed, such as consolidation material, spraying material, back-filling material, sealing material, waterproof material. These mining materials have been applied and promoted in coal mines. The solid waste content of back-filling material exceed 90%, providing low-cost and high efficient filling solution for backfill mining. This high barrier technical solution creates great economic and social benefits. Consolidation material have outstanding properties of inherent non-combustibility, water resistance, chemical stability and low cost. This new technology thoroughly solved the major safety hazards of high reaction temperature and easy combustion in mainstream products. The technology of …

Dewatering Optimization Strategies In Support Of Closure By Removal (Cbr) To Accelerate Groundwater Cleanup At Coal Combustion Residual Sites (Ccr) With Case Study, Sean Larkin, Jacob Chu

World of Coal Ash Proceedings

Dewatering Optimization Strategies in Support of Closure by Removal (CBR) to Accelerate Groundwater Cleanup at CCR Sites with Case Study Authors Mr. Sean Larkin - United States - Haley & Aldrich Inc. Dr. Jacob Chu - United States - Haley & Aldrich Inc. Abstract This presentation is focused on coal combustion residual (CCR) sites in corrective action that are performing closure-by-removal (CBR) in support of an overall groundwater remedy. CBR is often coupled with a variety of groundwater treatment options, including (but not limited to), monitored natural attenuation and/or contingent active or passive treatment of areas within the plume where …

Integrated Approach Of Plant D&D And Ccr Closure, Cassie Dumoulin, Mark Rokoff

World of Coal Ash Proceedings

With the impending finalization of the proposed legacy CCR SI Rule, several changes are expected to the definition and requirements for legacy CCR sites including CCRMUs. As utilities prepare to conduct the CCRMU Facility Evaluation Reports for legacy CCR sites, the challenge is now knowing where to look and anticipate where CCR may be. This presentation provides a description of the CCR that has been located/discovered as part of the demolition and decommissioning (D&D) of former coal-fired power plants and based on these historical locations the anticipated challenges as utilities address requirements within the proposed legacy CCR SI Rule. Case …

Fasting And Glucose Metabolism Differentially Impact Peripheral Inflammation In Human Type 2 Diabetes, Gabriella H. Kalantar, Shubh Saraswat, Sara Santacruz-Calvo, Fatemeh Gholamrezaeinejad, Aida Javidan, Madhur Agrawal, Rui Liu, Philip A. Kern, Xiaohua Douglas Zhang, Barbara S. Nikolajczyk

Biostatistics Faculty Publications

Cytokines produced by peripheral T-helper 1/17 cells disproportionately contribute to the inflammation (i.e., metaflammation) that fuels type 2 diabetes (T2D) pathogenesis. Shifts in the nutrient milieu could influence inflammation through changes in T-cell metabolism. We aimed to determine whether changes in glucose utilization alter cytokine profiles in T2D. Peripheral blood mononuclear cells (PBMCs), CD4+ T-cells, and CD4+CD25- T-effector (Teff) cells were isolated from age-matched humans classified by glycemic control and BMI. Cytokines secreted by CD3/CD28-stimulated PBMCs and Teff were measured in supernatants with multiplex cytokine assays and a FLEXMAP-3D. Metabolic activity of stimulated CD4+ T-cells was measured by a Seahorse …

Design Optimization Of A Direct-Drive Wind Generator With A Reluctance Rotor And A Flux Intensifying Stator Using Different Pm Types, Ali Mohammadi, Oluwaseun A. Badewa, Yaser Chulaee, Donovin D. Lewis, Somasundaram Essakiappan, Madhav Manjrekar, Dan M. Ionel

Power and Energy Institute of Kentucky Faculty Publications

This paper presents a large-scale multi-objective design optimization for a direct-drive wind turbine generator concept that is based upon an experimentally validated computational model for a small-scale prototype motor of the same type. By integrating an outer reluctance-type rotor and a segmented stator with toroidally wound single-coil modules containing spoke-type PMs, the design optimization aims to minimize losses, active mass, and torque ripple while adhering to a power factor constraint. The AC windings and PMs are positioned in the stator and this concept enhances flux concentration, enabling the use of more affordable high energy non-rare-earth (special type) magnets. The exterior …

Optimization, Characterization, And Comparison Of Two Luciferase-Expressing Mouse Glioblastoma Models, Louis Rodgers, Julia A. Schulz Pauly, Bryan J. Maloney, Anika M. S. Hartz, Bjoern Bauer

UK CARES Faculty Publications

Glioblastoma (GBM) is the most aggressive brain cancer. To model GBM in research, orthotopic brain tumor models, including syngeneic models like GL261 and genetically engineered mouse models like TRP, are used. In longitudinal studies, tumor growth and the treatment response are typically tracked with in vivo imaging, including bioluminescence imaging (BLI), which is quick, cost-effective, and easily quantifiable. However, BLI requires luciferase-tagged cells, and recent studies indicate that the luciferase gene can elicit an immune response, leading to tumor rejection and experimental variation. We sought to optimize the engraftment of two luciferase-expressing GBM models, GL261 Red-FLuc and TRP-mCherry-FLuc, showing differences …

Matching Study Design To Prescribing Intention, Bethany L. Diprete, Gyeon Oh, Daniela C. Moga, Nabarun Dasgupta, Svetla Slavova, Emily Slade, Chris Delcher, Brian W. Pence, Shabbar I. Ranapurwala

Biostatistics Faculty Publications

Purpose: In drug studies, research designs requiring no prior exposure to certain drug classes may restrict important populations. Since abuse-deterrent formulations (ADF) of opioids are routinely prescribed after other opioids, choice of study design, identification of appropriate comparators, and addressing confounding by “indication” are important considerations in ADF post-marketing studies. Methods: In a retrospective cohort study using claims data (2006–2018) from a North Carolina private insurer [NC claims] and Merative MarketScan [MarketScan], we identified patients (18–64 years old) initiating ADF or non-ADF extended-release/long-acting (ER/LA) opioids. We compared patient characteristics and described opioid treatment history between treatment groups, classifying patients as …

Quantifying Image Quality In Aoslo Images Of Photoreceptors, Brea D. Brennan, Heather Heitkotter, Joseph Carroll, Sergey Tarima, Robert F. Cooper

Biostatistics Faculty Publications

The use of “quality” to describe the usefulness of an image is ubiquitous but is often subject to domain specific constraints. Despite its continued use as an imaging modality, adaptive optics scanning light ophthalmoscopy (AOSLO) lacks a dedicated metric for quantifying the quality of an image of photoreceptors. Here, we present an approach to evaluating image quality that extracts an estimate of the signal to noise ratio. We evaluated its performance in 528 images of photoreceptors from two AOSLOs, two modalities, and healthy or diseased retinas. The algorithm was compared to expert graders’ ratings of the images and previously published …

Plant Model Of Α-Synucleinopathy: Expression Of Α-Synuclein A53t Variant In Hairy Root Cultures Leads To Proteostatic Stress And Dysregulation Of Iron Metabolism, Jasmina Kurepa, Kristen A. Bruce, Greg A. Gerhardt, Jan A. Smalle

Neurology Faculty Publications

Synucleinopathies, typified by Parkinson’s disease (PD), entail the accumulation of α- synuclein (αSyn) aggregates in nerve cells. Various αSyn mutants, including the αSyn A53T variant linked to early-onset PD, increase the propensity for αSyn aggregate formation. In addition to disrupting protein homeostasis and inducing proteostatic stress, the aggregation of αSyn in PD is associated with an imbalance in iron metabolism, which increases the generation of reactive oxygen species and causes oxidative stress. This study explored the impact of αSyn A53T expression in transgenic hairy roots of four medicinal plants (Lobelia cardinalis, Artemisia annua, Salvia miltiorrhiza, and Polygonum multiflorum). In all …

Effect Of Simulated Gastrointestinal Digestion On Antioxidant, And Anti-Inflammatory Activities Of Bioactive Peptides Generated In Sausages Fermented With Staphylococcus Simulans Qb7, Hongying Li, Hongbing Fan, Zihan Wang, Qiujin Zhu, Jianping Wu

Animal and Food Sciences Faculty Publications

Dry-fermented sausages are a good source of bioactive peptides, whose stability against gastrointestinal (GI) digestion determines their bioaccessibility. This study focused on evaluating the effect of peptide extracts from sausages fermented with Staphylococcus simulans QB7 during in vitro simulated GI digestion, including peptide profi les and antioxidant and anti-infl ammatory activities. Peptides present in sausages were degraded during digestion, with molecular weight reduced from > 12 kDa to < 1.5 kDa. Besides, the content of amino acids increased from 381.15 to 527.07 mg/g, especially tyrosine being found only after GI digestion. The anti-infl ammatory activities were increased after GI digestion, however, the changes in antioxidant activities were the opposite. A total number of 255, 252 and 386 peptide sequences were identified in undigested, peptic-digested and GI-digested samples, respectively. PeptideRanker, BIOPEP-UWM and admetSAR were used to further predict the functional properties and intestinal absorption of the identified peptide sequences from GI digestion. Finally, 18 peptides were discovered to possess either antioxidant or anti-infl ammatory capacities.

Trilogies: Lessons From 50 Years Facilitating Community-Based Health Assessments And Planning In Appalachia, Bruce Behringer

Journal of Appalachian Health

Involvement of community and organizational groups is fundamental to most public ventures. Most social, health, economic, and educational improvements in Appalachia have been characterized by successfully integrating community input and finding ways to encourage organizational change and collaboration.

Managing group process and related facilitation skills are fundamental competencies for public health professionals and others guiding change efforts. Groups from communities and organizations can get stalled in their deliberations; a facilitator frequently must think quickly to diagnose the situation and propose alternative approaches. Creative and flexible approaches, learned through practice experiences, can blend with theories and frameworks learned in academic preparation …

Building A Roadmap For Web Archiving: Organizational Sustainability In An American Research University Library, Ruth E. Bryan, Emily B. Collier

Library Presentations

The presenters, archivists in an academic university Library, launched a web archiving program for a public university in the United States in 2018 with a three-year Archive-it contract. In the first six years of the web archiving program, we have laid the groundwork for an ongoing web archiving program through robust documentation built in anticipation of potential loss of resources, especially personnel. In this presentation, we report on a sustainability review of the program using a practical framework and a conceptual framework. The practical framework is the University of Pittsburg's Socio-Technical Sustainability Roadmap (https://sites.haa.pitt.edu/sustainabilityroadmap/). The conceptual framework is Kristin R. …

Preserving The Uncrawlable: Serving The Server, Andrew Mcdonnell

Library Presentations

Many of the challenges inherent in archiving dynamic web content revolve around the capture and playback of ever-evolving social media sites. However, older dynamic web content that has ceased to evolve continues to elude the tools and conventions most widely available to web archivists. This presentation will share work conducted to preserve an online digital humanities project that defied preservation via Archive-It and other crawler-based web archiving tools. The presentation will, moreover, offer an exploration of alternative options for web archivists struggling to preserve sites dependent on server-side processes for their essential functionality.

Suda On Line is a collaborative digital …

Decistifying Trans And Gender Diverse Inclusion In Library Work: A Literature Review, Stephen G. Krueger, Keahi Adolpho

Library Faculty and Staff Publications

This comprehensive review illuminates the current state of scholarly literature on trans and gender diverse inclusion in libraries, with the intention to provide a foundation and identify gaps for further research. Covering 50 works published between 2002 and 2023 in the areas of general inclusion, public libraries, academic libraries, experiences of library workers, archives, information behavior, and cataloging, we found that, with the exception of works on archives and cataloging, little scholarly literature goes beyond introductory talking points on basic information about trans and gender diverse people. We conclude with a call for much more in-depth research on this essential …

Genetic Manipulation Of Sainfoin Leaf Tannins, M Y. Gruber, P Auser, G Lees, A D. Muir, M Wood

IGC Proceedings (1977-2023)

An isogenic population of sainfoin (Onobrychis viciifolia Scop.) plants was developed by two methods; regeneration after long term tissue culture and plant transformation with an antisense chalcone synthase gene. Tannin (proanthocyanidin) content could be dramatically increased in untransformed callus by long term culture, but was not significantly altered in regenerating plantlets. Some of the mature transgenic plants had dramatically reduced levels of leaf tannin. The antisense gene was eliminated from all transgenic plants later in development.

Chromosomal 3q Amplicon Encodes Essential Regulators Of Secretory Vesicles That Drive Secretory Addiction In Cancer, Xiaochao Tan, Shike Wang, Guan-Yu Xiao, Chao Wu, Xin Liu, Biyao Zhou, Yu Jiang, Dzifa Y. Duose, Yuanxin Xi, Jing Wang, Kunika Gupta, Apar Pataer, Jack A. Roth, Michael P. Kim, Fengju Chen, Chad J. Creighton, William K. Russell, Jonathan M. Kurie

Markey Cancer Center Faculty Publications

Cancer cells exhibit heightened secretory states that drive tumor progression. Here, we identified a chromosome 3q amplicon that serves as a platform for secretory regulation in cancer. The 3q amplicon encodes multiple Golgi-resident proteins, including the scaffold Golgi integral membrane protein 4 (GOLIM4) and the ion channel ATPase secretory pathway Ca2+ transporting 1 (ATP2C1). We show that GOLIM4 recruited ATP2C1 and Golgi phosphoprotein 3 (GOLPH3) to coordinate Ca2+ -dependent cargo loading, Golgi membrane bending, and vesicle scission. GOLIM4 depletion disrupted the protein complex, resulting in a secretory blockade that inhibited the progression of 3q-amplified malignancies. In addition to its role …

Will Our Future Selves Thank Us? An Examination Of Born-Digital Curation Practices At The University Of Kentucky Libraries, Megan M. Mummey, Andrew Mcdonnell, Emily B. Collier, Sarah Dorpinghaus, Ruth E. Bryan

Library Presentations

Cultural heritage resources are increasingly being produced and distributed digitally yet the world of physical materials has not declined. Can you realign current resources to meet future collection needs while at the same time continuing with existing collection needs? Analog-based archival theory and practice is still relevant, but born-digital formats make acquisition, appraisal, resource allocation, collection management, and external relationships much more challenging. These challenges range from monetary and environmental costs to resource allocation to social media technology woes to campus-wide IT relationships.

In this presentation, University of Kentucky archivists share practical tips, tools, and mental frameworks to identify gaps, …

Neurotensin Modulates Ovarian Vascular Permeability Via Adherens Junctions, Andrew Pearson, Ketan Shrestha, Thomas E. Curry, Diane M. Duffy

UK CARES Faculty Publications

Neurotensin (NTS) is a 13-amino acid peptide which is highly expressed in the mammalian ovary in response to the luteinizing hormone surge. Antibody neutralization of NTS in the ovulatory follicle of the cynomolgus macaque impairs ovulation and induces follicular vascular dysregulation, with excessive pooling of red blood cells in the follicle antrum. We hypothesize that NTS is an essential intrafollicular regulator of vascular permeability. In the present study, follicle injection of the NTS receptor antagonist SR142948 also resulted in vascular dysregulation. To measure vascular permeability changes in vitro, primary macaque ovarian microvascular endothelial cells (mOMECs) were enriched from follicle aspirates …

Southeastern Law Librarian Spring 2024, Seaall

Newsletters

No abstract provided.

Open Educational Resources In Kentucky, Stephen G. Krueger, Todd Seguin, Colleen Deel, Aj Boston, Lidiya Grote, Bailey Lake, Katrina Salley, Stacy Scott, Kelly Smith, Maria Taylor, Kathleen Richardson

Library Faculty and Staff Publications

Open educational resources (OER) play an increasingly important role in the education landscape, with increased awareness and use year over year (Coffey). Often, academic libraries play a supporting role for instructors as they locate, adopt, and create OER for their courses. In this article, we will provide an introduction to OER, outline some current trends in open education, and describe a few of the OER initiatives currently underway in Kentucky’s college and university libraries.