Digital Commons Network^™

Issues Related To The Numerical Implementation Of A Sparse Method For The Solution Of Volume Integral Equations At Low Frequencies, Kiran Arcot

University of Kentucky Master's Theses

Computational electromagnetic modeling involves generating system matrices by discretizing integral equations and solving the resulting system of linear equations. Many methods of solving the system of linear equations exist and one such method is the factorization of the matrix using the so called local-global solution (LOGOS) modes. Computer codes to perform the discretization of the integral equations, filling of the matrix, and the subsequent LOGOS factorization have previously been developed by others. However, these codes are limited to complex double precision arithmetic only.

This thesis extends and expands the existing computer by creating a more general implementation that is able …

A Novel Message Routing Layer For The Communication Management Of Distributed Embedded Systems, Darren Jacob Brown

University of Kentucky Master's Theses

Fault tolerant and distributed embedded systems are research areas that have the interest of such entities as NASA, the Department of Defense, and various other government agencies, corporations, and universities. Taking a system and designing it to work in the presence of faults is appealing to these entities as it inherently increases the reliability of the deployed system. There are a few different fault tolerant techniques that can be implemented in a system design to handle faults as they occur. One such technique is the reconfiguration of a portion of the system to a redundant resource. This is a difficult …

Inhibition Of Cholesterol Synthesis By Policosanol, Subhashis Banerjee

University of Kentucky Doctoral Dissertations

Cholesterol is an essential component of the cell, but excessive blood levels are a major risk factor for the development of atherosclerotic plaques that can lead to heart disease and stroke, the foremost cause of premature death in Western societies. Policosanol, a mixture of very long chain alcohols derived from sugarcane, has gained considerable attention among the public as safe and effective means to reduce blood cholesterol levels, a belief based on some early clinical studies. My research investigates one possible mechanism by which policosanol might decrease blood cholesterol levels: the inhibition of cholesterol synthesis in the liver. Previous studies …

Distraction Osteogenesis In An Organ Culture Model, Bradley R. Heil

University of Kentucky Master's Theses

Distraction osteogenesis (DO) is a surgical procedure in which applied strain stimulates new bone growth; however, the underlying mechanisms by which bone cells respond to load are still uncertain. An organ culture model of DO was developed and validated by using linear distraction on the femoral shafts of 5 day old Wistar rats. Two loading regimes were utilized: distracting the bones for 2 hrs on day 1 (GRP I); distracting the bones for 2 hrs on days 1, 3, and 5 (GRP II). After 1 week in culture, the bones were compared to unloaded contralateral controls and assessed for changes. …

Building Sustainable Societies: Exploring Sustainability Policy And Practice In The Age Of High Consumption, Cindy Isenhour

University of Kentucky Doctoral Dissertations

This dissertation is an attempt to examine how humans in wealthy, post-industrial urban contexts understand sustainability and respond to their concerns given their sphere of influence. I focus specifically on sustainable consumption policy and practice in Sweden, where concerns for sustainability and consumer-based responses are strong. This case raises interesting questions about the relative strength of sustainability movements in different cultural and geo-political contexts as well as the specific factors that have motivated the movement toward sustainable living in Sweden.

The data presented here supports the need for multigenic theories of sustainable consumerism. Rather than relying on dominant theories of …

The Social Relations Of Tourism On The Perhentian Islands., Jacqueline L. Salmond

University of Kentucky Doctoral Dissertations

In recent years there has been an increase in the adoption of tourism as an economic strategy in many developing nations and a growing interest in how communities and individuals engage with tourism. This parallels research which aims to uncover alternative readings of community participation in forms of economic and social development. This research uses tourism as a lens to understand the economic subjectivity of communities engaged in tourism. Focusing on how the local populations understand, experience and participate in tourism, it paints a picture of the Perhentian Islands which challenges existing understandings of individual and community participation in tourism. …

An Empirical Analysis Of Reputation Effects And Network Centrality In A Multi-Agency Context, Emily Jane Plant

University of Kentucky Doctoral Dissertations

Signals convey information to marketplace participants regarding the unobservable quality of a product. Whenever product quality if unobservable prior to purchase, there is the risk of adverse selection. Problems of hidden information also occur in the consumer marketplace when the consumer is unable to verify the quality of a good prior to purchase. The sending, receiving, and interpretation or signals are potential ways to overcome the problem of adverse selection. In general, there is a lack of empirical evidence for signaling hypothesis, particularly that which links signaling to business performance outcomes. This research proposes that reputation serves as a marketplace …

The Role Of The L-Type Calcium Channel And Its Carboxyl-Terminus, Miranda Jean Byse

University of Kentucky Doctoral Dissertations

In the heart, the primary role of the L-type calcium channel (LTCC) Ca_V1.2 is to conduct calcium into cardiomyocytes and initiate contraction. However, part of the Ca_V1.2 channel itself, the cleaved carboxyl-terminus (CCt) can also localize to the nucleus and regulate gene transcription. Therefore, the goal of this dissertation project was to determine the role and regulation of CCt in the embryonic and adult heart. The global hypothesis of my dissertation project is that CCt localizes to the nucleus in embryonic and adult cardiomyocytes via a calcium-mediated mechanism and regulates transcription. A model of pharmacological LTCC …

Protection Against Endothelial Inflammation By Green Tea Flavonoids, Yuanyuan Zheng

University of Kentucky Doctoral Dissertations

Endothelial inflammation is a pivotal early event in the development of atherosclerosis. Long term exposure to cardiovascular risk factors will ultimately exhaust those protective anti-inflammatory factors such as the heme oxygenase (HO) system. The HO system plays a critical role in cellular and tissue self-defense against oxidative stress and inflammation. Caveolae are membrane domains and are particularly abundant in endothelial cells, where they are believed to play a major role in the regulation of endothelial vesicular trafficking as well as the uptake of lipids and related lipophilic compounds, possibly including bioactive food components such as flavonoids. Research in this dissertation …

Laminar-Turbulent Transition For Attached And Separated Flow, Qian Zhang

University of Kentucky Doctoral Dissertations

A major challenge in the design of turbomachinery components for aircraft gas turbine engines is high cycle fatigue failures due to flutter. Of particular concern is the subsonic/transonic stall flutter boundary which occurs at part speed near the stall line. At these operating conditions the incidence angle is large and the relative Mach number is high subsonic or transonic. Viscous effects dominate for high incidence angles.

In order to predict the flutter phenomena, accurate calculation of the steady and unsteady aerodynamic loading on the turbomachinery airfoils is necessary. The development of unsteady aerodynamic models to predict the unsteady forces and …

Moroccan Women And Immigration In Spanish Narrative And Film (1995-2008), Sandra Stickle Martín

University of Kentucky Doctoral Dissertations

Spanish migration narratives and films present a series of conflicting forces: the assumptions of entitlement of both Western and Oriental patriarchal authority, the claims to autonomy and self determination by guardians of women’s rights, the confrontations between advocates of exclusion and hospitality in the host society, and the endeavor of immigrant communities to maintain traditions while they integrate into Spanish society. Taking into consideration current theories of space, mobility, feminism, and assimilation, I center my analysis on four significant moments of migration: the inundation of Western media in other countries that inspires individuals to find alternatives to poverty and oppression; …

Immobilization Of Mercury And Arsenic Through Covalent Thiolate Bonding For The Purpose Of Environmental Remediation, Lisa Y. Blue

University of Kentucky Doctoral Dissertations

Mercury and arsenic are widespread contaminants in aqueous environments throughout the world. The elements arise from multiple sources including mercury from coal-fired power plants and wells placed in natural geological deposits of arseniccontaining minerals. Both elements have significant negative health impacts on humans as they are cumulative toxins that bind to the sulfhydryl groups in proteins, disrupting many biological functions. There are currently no effective, economical techniques for removing either mercury or arsenic from aqueous sources. This thesis will demonstrate a superior removal method for both elements by formation of covalent bonds with the sulfur atoms in N,N’-Bis(2-mercaptoethyl)isophthalamide (commonly called …

Effect Of Fluorination On Partitioning Behavior And Bilayer Self Assembly, Vivian Aramide Ojogun

University of Kentucky Doctoral Dissertations

Fluorinated systems are defined by unique properties that offer advantages in drug delivery, material synthesis and industrial applications. In comparison to their hydrocarbon counterparts, the design of fluorinated solutes for tailored applications is limited by the inability to predict the effect of fluorination on phase behavior. This work examines and interprets the influence of fluorination on the phase behavior of fluorinated solutes and surfactants, with emphasis on their impact on vesicle bilayers.

Thermodynamic partitioning of functionalized series of fluorinated and hydrocarbon nicotinate prodrugs fashioned to promote solubility in a fluorocarbon solvent (perfluorooctyl bromide; PFOB) is measured. Predictive approaches are also …

Health Promotion And Health Education: Nursing Students’ Perspectives, Kathleen Ann Halcomb

University of Kentucky Doctoral Dissertations

The purpose of this study was to determine student nurses’ perceptions of (1) the role of the nurse in health promotion, and (2) how the concept of health promotion is presented in nursing curricula. Research questions for this study included the following: 1) Can nursing students explain the difference between health education and health promotion? 2) What have nursing students been exposed to within their curriculum regarding health promotion? 3) What health promoting behaviors are nursing faculty role modeling as perceived by nursing students? 4) What is the role of the nurse in implementing health promotion as perceived by nursing …

The Effect Of Acupressure On Constipation, Quality Of Life, And Depressive Symptoms In Cancer Patients With Constipation, Eun Jin Lee

University of Kentucky Doctoral Dissertations

Constipation is the most common gastrointestinal complaint in the United States, resulting in about 2 million annual visits to the doctor.

The purposes of this dissertation were to: 1) describe four theories of traditional Korean medicine; 2) review mechanisms of acupuncture and moxibustion and develop a conceptual model; 3) review findings from randomized controlled trials that tested the effects of acupressure used for the management of symptoms such nausea, pain, and dyspnea; 4) examine the reliability and validity of the Patient Health Questionnaire-9 (PHQ-9) in heart failure patients with constipation compared to those with gastrointestinal disease; 5) describe how Korean …

La Mujer Se Va Pa’Bajo: Women’S Health At The Intersections Of Nationality, Class, And Gender, Mary Alice Scott

University of Kentucky Doctoral Dissertations

This research utilizes an intersectionality framework to examine the complexity of social location and its effects on women's health. By examining connections among the state, processes of globalization, and the production of health inequalities for poor women in a rural community in southern Veracruz, Mexico, the research highlights the nexus of nationality, class, and gender. Four interconnected contexts are explored: (1) women's increasing paid and unpaid labor in the context of a poverty of resources brought on by sustained economic crisis; (2) the maintenance of reproductive labor as the responsibility of women; (3) the development of migrant "illegality" and its …

When Battered Persons Kill: The Impact Of Gender Stereotypes On Mock Juror Perceptions, Emily Catherine Hodell

University of Kentucky Doctoral Dissertations

The present experiment investigated the role of gender stereotypes in cases in which a battered person kills his or her abuser. Regression analysis revealed an overall gender bias such that mock jurors were more likely to convict a man defendant who had killed his abusive wife than they were when a woman defendant who had killed her husband. Mediational analyses indicated that the relationship between abuser gender and verdict was partially mediated by sympathy toward the victim, and fully mediated by sympathy toward the defendant. Regression analysis also revealed an effect of abuser height, such that conviction rates were higher …

Boundaries Of Modernity: Spanish Women Writers At The Turn Of The Twentieth Century, Carmen Arranz

University of Kentucky Doctoral Dissertations

Spanish women writers that establish their literary careers early in twentieth century find themselves at an interesting historical crossroads as the world changes from an agrarian to an industrial paradigm. On one hand, this change leads to a strong current of traditionalism, to which most male writers adhere, as it offers the attractive idea of return to a pre-modern simplicity; on the other, this change opens up possibilities for social improvement and participation for those groups traditionally excluded from power. Embracing this change poses the opportunity for female subjects to reshape fundamental structures of society and, in sum, eventually create …

Stalking Myth Acceptance: An Investigaton Of Attitudinal Constructs Associated With Gender Differences In Judgments Of Intimate Stalking, Emily Elizabeth Dunlap

University of Kentucky Doctoral Dissertations

Emerging research has shown that women and men perceive criminal stalking differently, yet there is little research addressing why these differences exist. For example, mock juror research on intimate stalking has found that men are more likely than women to render lenient judgments (e.g., not-guilty verdicts). Understanding the underlying attitudes associated with differences in how men and women interpret whether certain behaviors would cause reasonable fear is crucial to an evaluation of current anti-stalking legislation. The primary goals of this research were: (1) to examine the extent to which beliefs that support stalking (i.e., stalking myth acceptance – SMA victim …

Representación De La Violencia En La Novela Del Narcotráfico Y El Cine Colombiano Contemporáneo, Claudia Ospina

University of Kentucky Doctoral Dissertations

This dissertation analyzes the representation of violence in Colombian novels and films from the last two decades of the XX century. Aided by current theories of violence and representation on the one hand, and an interdisciplinary methodology that analyses the phenomenon of the violence of drug trafficking from different perspectives on the other, my analysis examines the challenges and limits of literary and cinematic representation as it grapples with the extreme realities of life in Colombia’s major cities. The central body of my thesis focuses on three novels and two films, selected for the marked differences that inform their generic …

Role Of Group X Secretory Phospholipase A2 In Murine Adipocytes, Xia Li

University of Kentucky Doctoral Dissertations

The secretory phospholipase A₂ (sPLA₂) family is a group of enzymes that catalyze the hydrolysis of glycerophospholipids at the sn-2 position, generating free fatty acids and lysophospholipids. The sPLA₂ family has been implicated in various physiological and pathological activities. Eleven sPLA₂’s have been identified in mammals, and the function of each isoform likely reflects its tissue distribution and substrate specificity. Studies in vitro indicate that Group X (GX) sPLA₂ potently releases arachidonic acid (AA) and lysophosphatidylcholine from mammalian cell membranes. Interestingly, some of the biological effects mediated by GX sPLA₂ in vitro …

Queer Appalachia: Toward Geographies Of Possibility, Mathias J. Detamore

University of Kentucky Doctoral Dissertations

Stereotypes about Appalachia abound through dubious and reductive representations of the ‘hillbilly’ icon. Sexuality and how it functions in Appalachia is usually cast from the outside as wild, violent, bestial, incestuous and generally base. Movies such as Deliverance and television shows such as The Beverly Hillbillies and The Dukes of Hazard render images of Appalachian sexuality as hyper-sexual, both naive and violent. These images of Appalachian sexual ignorance and violence that permeate popular culture have had problematic and reductive implications for rural gay/trans Appalachian folk. Mainstream gay culture has often used the perceived meanings of these images to circumscribe and …

The Role Of Abcg2 In Drug Active Transport In Milk, Lipeng Wang

University of Kentucky Doctoral Dissertations

Drug active transport into milk is a major concern for breastfeeding mothers and healthcare providers. Studies from the literature indicated that breast cancer resistance protein (ABCG2) plays an important role in drug transfer into milk. There has been limited study on stereoselective interactions with ABCG2. A mechanistic analysis of flux across cell monolayer model is a critical first step toward extrapolating in vitro results for predicting in vivo disposition (including distribution into milk), drug disposition or drug-drug interactions.

The objectives of this thesis were (1) to establish a “Chemical knockout model” in rat for studying drug accumulation into milk, (2) …

Near-Field Radiative Transfer: Thermal Radiation, Thermophotovoltaic Power Generation And Optical Characterization, Mathieu Francoeur

University of Kentucky Doctoral Dissertations

This dissertation focuses on near-field radiative transfer, which can be defined as the discipline concerned with energy transfer via electromagnetic waves at sub-wavelength distances. Three specific subjects related to this discipline are investigated, namely nearfield thermal radiation, nanoscale-gap thermophotovoltaic (nano-TPV) power generation and optical characterization. An algorithm for the solution of near-field thermal radiation problems in one-dimensional layered media is developed, and several tests are performed showing the accuracy, consistency and versatility of the procedure. The possibility of tuning near-field radiative heat transfer via thin films supporting surface phononpolaritons (SPhPs) in the infrared is afterwards investigated via the computation of …

Nanoscale Functionalization And Characterization Of Surfaces With Hydrogel Patterns And Biomolecules, Hariharasudhan Chirra Dinakar

University of Kentucky Doctoral Dissertations

The advent of numerous tools, ease of techniques, and concepts related to nanotechnology, in combination with functionalization via simple chemistry has made gold important for various biomedical applications. In this dissertation, the development and characterization of planar gold surfaces with responsive hydrogel patterns for rapid point of care sensing and the functionalization of gold nanoparticles for drug delivery are highlighted.

Biomedical micro- and nanoscale devices that are spatially functionalized with intelligent hydrogels are typically fabricated using conventional UV-lithography. Herein, precise 3-D hydrogel patterns made up of temperature responsive crosslinked poly(N-isopropylacrylamide) over gold were synthesized. The XY control of the hydrogel …

What Nurses Say: Communication Behaviors Associated With The Competent Nursing Handoff, Anne Claiborne Ray Streeter

University of Kentucky Doctoral Dissertations

Communication competence and medical communication competence served as the theoretical framework for this research that seeks to identify specific communication behaviors associated with what nurses say constitute a communicatively competent patient handoff at the nursing change of shift. Data collected from 286 nurses responding to an online modified Medical Communication Competence Scale posted at www.allnurses.com supported the hypotheses that information exchange (information giving, seeking and verifying) and socioemotional communication behaviors are rated more highly in the best patient handoffs than in the worst ones. Research questions found that the incoming nursing role rated behaviors associated with information verifying and socioemotional …

Health Literacy: A Bibliometric And Citation Analysis, Robert M. Shapiro Ii

University of Kentucky Master's Theses

The concept of health literacy finds its origins in the field of education. In its brief history the definition, structure, and direction of the field has changed dramatically and has emerged as a multidisciplinary endeavor full of discipline specific manifestations, most recently, public health literacy. Using bibliometric and citation analyses, this study investigated the field of health literacy from the first use of the term in 1974 to the present year, 2010. A range of databases from the various fields that have contributed to the field were searched using the keyword string, “health literacy.” Data was organized, cleaned and parsed …

Arsenite Oxidation By Pure Cultures Of Thiomonas Arsenivorans Strain B6 In Bioreactor Systems, Aniruddha Dastidar

University of Kentucky Doctoral Dissertations

The removal of arsenic toxicity from water is accomplished by a preliminary preoxidative step transforming the most toxic form, arsenite (As (III)), to the least toxic form, arsenate (As (V)). The potential of As (III) oxidation to As (V) was initially investigated in batch reactors using the chemoautotrophic Thiomonas arsenivorans strain b6 under varying initial As (III) and cell concentrations and at optimal pH and temperature conditions (pH 6.0 and temperature 30°C). The strain b6 completely oxidized As (III) to As (V) during exponential growth phase for lower levels of As (III) concentrations (≤ 100 mg/L) but continued into stationary …

Why Do They Go? Community College Students And Post-Secondary Pursuits In Central Appalachia, Christina Jo Wright

University of Kentucky Doctoral Dissertations

This dissertation focuses on how rural community college students make decisions regarding their post-secondary plans. To understand these decision processes, I interviewed students, faculty and administrators at Southeast Community and Technical College in Harlan County, Kentucky. The literature informing my research reflects on rural college going patterns. Most studies connect place and post-secondary plans. Central Appalachia has among the lowest population percentages with Bachelor degrees in the country. Studies argue this is because of limited application for such degrees in the region. Matching their education and training to local job market requirements, people hesitate to complete advanced degrees when little …

Nm23-H1 Blocks Cell Motility Independently Of Its Known Enzymatic Activities In A Cohort Of Human Melanoma Cells, Joseph Robert Mccorkle

University of Kentucky Doctoral Dissertations

The metastasis suppressor gene NM23-H1 has been shown to possess three enzymatic activities including nucleoside diphosphate kinase, histidine-dependent protein kinase and 3’-5’ exonuclease activity. While these properties have been demonstrated in vitro using recombinant proteins, the contribution of these activities to suppression of metastatic dissemination is unknown. Site-directed mutagenesis studies were used to identify amino acid residues which are required for proper function of each enzymatic activity associated with H1, providing a platform for studying the importance of each function on an individual basis. To assess the relevance of these activities to melanoma progression, a panel of mutants harboring selective …