Digital Commons Network^™

Upregulation Of Cd36, A Fatty Acid Translocase, Promotes Colorectal Cancer Metastasis By Increasing Mmp28 And Decreasing E-Cadherin Expression, James Drury, Piotr G. Rychahou, Courtney O. Kelson, Mariah E. Geisen, Yuanyuan Wu, Daheng He, Chi Wang, Eun Y. Lee, B. Mark Evers, Yekaterina Y. Zaytseva

Surgery Faculty Publications

Altered fatty acid metabolism continues to be an attractive target for therapeutic intervention in cancer. We previously found that colorectal cancer (CRC) cells with a higher metastatic potential express a higher level of fatty acid translocase (CD36). However, the role of CD36 in CRC metastasis has not been studied. Here, we demonstrate that high expression of CD36 promotes invasion of CRC cells. Consistently, CD36 promoted lung metastasis in the tail vein model and GI metastasis in the cecum injection model. RNA-Seq analysis of CRC cells with altered expression of CD36 revealed an association between high expression of CD36 and upregulation …

Southeastern Law Librarian Winter 2022, Seaall

Newsletters

No abstract provided.

The Federally Regulated Decline, Rebirth, And Decline Of The United States Hemp Industry, Henry Webb, Patrick R. Baker, Paula H. Moore, Karen Scanlon

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Demand Analysis Of Vietnamese Coffee In The U.S., Leo Kyaw Zin

Theses and Dissertations--Agricultural Economics

Coffee production in Vietnam has increased almost 100-fold within the past three decades, positioning it to become the second-largest coffee exporter in the world after Brazil. The U.S. is a top market for Vietnamese coffee. In this study, we estimate a conditional demand system of expenditure share equations for coffee from Vietnam, Brazil, Colombia, and an aggregate of seven other countries in the U.S. coffee market using the Linear Approximation Almost Ideal Demand System (LA/AIDS) and based on monthly time-series data from 2000 to 2020 with a total of 252 observations. Compensated and uncompensated own-price, cross-price, and expenditure elasticities were …

A Study Of Underrepresented Minorities In An Informal Stem Experience, Rachel Rogers

Theses and Dissertations--Education Sciences

According to labor market data, there is core cognitive knowledge, skills, and abilities associated with STEM education that are in demand in not just STEM fields, but all areas of the workforce (Carnevale, Smith, & Melton, 2011; Rothwell, 2013). During the period from 2005 until 2015, STEM professions grew by 24.4% (Noonan, 2017). During this time, populations such as minorities continued to show a gap in their representation in STEM (Noonan, 2017). To effectively examine how to increase the rate of URM student success in STEM, more research is needed on the factors that might contribute to minority STEM interest, …

Ready Lawyer One: Lawyering In The Metaverse, Michael D. Murray

Law Faculty Popular Media

No abstract provided.

Learner Outcomes From An Echo In Augmentative And Alternative Communication, Lillie Reinhart

Theses and Dissertations--Communication Sciences and Disorders

Background: Students with complex communication needs (CCN) rely on the use of augmentative and alternative communication (AAC) to support their communication; however, many students are leaving high school without an effective form of communication. To build capacity and increase school professionals’ knowledge and self-efficacy in AAC, this thesis used an adaptation of Project ECHO (Extension for Community Healthcare Outcomes) for use with AAC.

Methods: Using a post then pre-retrospective survey, participants self-reported changes in knowledge, confidence, and overall satisfaction with ECHO sessions. Paired sample t-tests assessed participant-reported change in knowledge. Frequency counts were used to analyze responses about confidence and …

Voluntary Control Of Breathing According To The Breathing Pattern During Listening To Music And Non-Contact Measurement Of Heart Rate And Respiration, Dibyajyoti Biswal

Theses and Dissertations--Biomedical Engineering

We investigated if listening to songs changes breathing pattern which changes autonomic responses such as heart rate (HR) and heart rate variability (HRV) or change in breathing pattern is a byproduct of listening to songs or change in breathing pattern as well as listening to songs causes changes in autonomic responses. Seven subjects (4 males and 3 females) participated in a pilot study where they listened to two types of songs and used a custom developed biofeedback program to control their breathing pattern to match the one recorded during listening to the songs.

Coherencies between EEG, breathing pattern and RR …

Increasing Hpv Vaccination In Elliott And Lawrence Counties, Keeghan Francis

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Appalachian counties within Kentucky have higher rates of HPV-related cancers, including cervical cancer. HPV vaccines are effective at reducing the risk of cervical cancer, but vaccination coverage in Appalachia remains low. The proposed program relies on recommended strategies to improve vaccine uptake by increasing access and demand for HPV vaccines. This will be done through school vaccine clinics and parent education on HPV, cervical cancer, and HPV vaccines.

Key Factors Associated With Late-Stage Diagnosis Of Endometrial Cancer In Kentucky, Lexee Long

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Objectives: Cancer of the endometrium is the most common female reproductive cancer in the United States, but is understudied in relation to stage at diagnosis, which is a potential predictor of survival. The primary objective of this study is to analyze potential associations of independent variables such as age at diagnosis, race, marital status, smoking status, Appalachian status, and insurance type with late-stage diagnosis of endometrial cancer.

Methods: This population-based study used Kentucky Cancer Registry data to study endometrial cancer cases diagnosed between January 1^st,2015 and December 31^st, 2019. Chi-square statistics were used to examine bivariate …

Black Men Need Love Too, Addressing Unaddressed Mental Health In African American Men, D'Quayvion Cloud

DSW Capstone Projects

The objective of this capstone is to analyze and demonstrate the importance of studies on unaddressed mental health among African American males. The major aim is to demonstrate why research, policy, and funding are vital to knowing how to work with this specific clinical group, allowing us to build effective and inclusive programs for these African American males and eliminate the stigma associated with members of this community. Due to unaddressed mental health and a lack of treatment options for our people, research has shown that African American men aged 20 to 24 had the highest suicide rate of any …

Music As An Instrument For Healing: Exploring Music Therapy For Increasing The Quality Of Life For Geriatric Veterans With Post-Traumatic Stress Disorder (Ptsd), Travis Adams

DSW Capstone Projects

Military personnel can sometimes be put in dangerous situations that expose them to various types of traumas. Due to the nature of their work, veterans may be at a higher risk for developing post-traumatic stress disorder (PTSD). PTSD is a complex and challenging mental health disorder with symptoms that evolve with time. Geriatric veterans with PTSD are a particular population with unique needs that require attention and care. Music therapy is explored as a potential intervention to increase geriatric veterans' quality of life with PTSD.

Product One was a systematic review that examined the effectiveness of music therapy in improving …

An Integrated, Holistic Approach To Supporting The Wellbeing Of The Contemporary Social Services Workforce, Julia Moore

DSW Capstone Projects

Despite nearly 40 years of research regarding the effects of psychological distress among the social services workforce, there remains a lack of congruity among scholars and experts regarding the definition and epidemiology of the distinct constructs, including secondary traumatic stress, vicarious trauma, compassion fatigue, and burnout. Current literature on these phenomena indicates that a lack of empirical methods for scientifically studying outcomes regarding effective prevention and intervention strategies have stalled efforts to advance the field of secondary trauma and create practical approaches to protecting the workforce serving trauma-exposed clients. This capstone project is focused on understanding the current literature regarding …

Systemic Solutions To Addressing Juvenile Sexual Offending, Alyscia Mayhugh

DSW Capstone Projects

Research on and treatment of juvenile sexual offenders has surged since the 1980s. While research on this social justice issue has expanded over the past four decades, little has been done in the United States to systemically address the recidivism rates of juvenile sexual offenders. The systematic literature review explores existing literature on this topic, with a focus on thematic categories that emerged through data extraction and analysis. The conceptual paper presents a unique idea for addressing juvenile sexual offending systemically, emphasizing the value of utilizing incrementalism and trauma theory to enact changes to existing systems. The final practice application …

An Examination Of Diabetes Prevention Program Translations For Eastern Kentucky, William H. Robinson

DSW Capstone Projects

This capstone project examined translations of the National Diabetes Prevention Program (DPP) that have been adapted to improve cultural competency and analyzed the potential application of these adaptations to serve communities in Eastern Kentucky. Findings in the project were synthesized using the Ecological Validity Model (EVM) posited by Bernal et al. (1995) and the RE-AIM framework developed by Glasgow et al. (1999). EVM and RE-AIM have been used in other systematic literature reviews of the DPP and provide a framework for conceptual analysis and practice application of the findings. This project recommends changes in public health policy and social work …

What's The Play? Using Social Learning Theory To Treat Men In Mental Health, Aaron Hemlepp

DSW Capstone Projects

Men have problems when it comes to mental health. Specifically, men are more likely to have a fatality of suicide than other genders and are more likely to have substance abuse problems than other genders. Combine this with societal problems such as the shrinking physical labor market and instability of family systems that have traditionally been seen as “men’s work.” The gender is not adapting to modern social functioning in the way that other genders have been, which means that therapy is not a useful tool for men and their problems. This means that therapy systems need an approach to …

Appalachians’ Intentions To Use Online And In-Person Counseling, Jade Hollan

Theses and Dissertations--Educational, School, and Counseling Psychology

Appalachians face higher rates of mental health concerns, yet they are less likely to have access to quality treatment. Online counseling, counseling using videoconferencing technology, may provide a viable solution to narrow this gap. However, little is known about Appalachians’ intention to use in-person or online counseling. This study examined Appalachians’ (N = 490) intentions to use online and in-person counseling using the theoretical framework of Theory of Planned Behavior (TPB; Ajzen, 1991). Results from structural equation modeling supported the indirect model for online and in-person counseling, where the associations between distal help-seeking factors (i.e., self-stigma, perceived stigma of …

News Treatment Of The Supreme Court: Language Selection, Ideological Directions, And Public Support, Alexander Denison

Theses and Dissertations--Political Science

In an increasingly diverse media landscape, how much of the ideological trends seen in current news reporting affect coverage of the U.S. Supreme Court? This work examines two different aspects of the Court's activities, their decisions and the confirmation hearings of Court nominees, analyzing what factors, if any, lead to differences in coverage language. Finally, through the use of a survey experiment, I analyze whether these differences in language, in combination with positive symbolic imagery, affect attitudes toward the institution. This work provides a novel consideration of whether the Court is subject to the same ideological slant found in coverage …

The Influence Of The Federalist Society On Judical Politics And Law In The United States, Peter S. K. Lynch

Theses and Dissertations--Political Science

This dissertation examines the Federalist Society, which is a network of conservative and libertarian attorneys, judges, law professors, and law students. The organization was founded by law students at Harvard Law School, Yale Law School, and the University of Chicago Law School in 1982, and has, over the last four decades, come to play a central role in law and politics in the United States. Individuals affiliated with the Federalist Society influence the law through a variety of avenues.

Federalist Society-members advance the goals of the conservative legal movement in a variety of capacities—by writing amicus curiae briefs providing the …

Elucidating The Role Of Polycomb Repressive Complex 2 In Lung Stem Cell Fate And Lung Disease, Aria Byrd

Theses and Dissertations--Toxicology and Cancer Biology

The average human lungs take ~22,000 breaths and inhale ~2,000 gallons of air each day. This organ is the primary conduit for the transfer of oxygen to the internal organs, making it crucial for the sustainment of life. Consequently, mechanical malfunction of the lungs and/or pollution of inhaled air negatively impact internal organ function and ultimately put survival in jeopardy. Epigenetics, by nature, is a plastic phenomenon in which environmental stimuli influence short term, long term, and generational gene expression patterns. Chronic exposure of harmful stimuli to the lung epithelium has also been shown to alter epigenetic pathways, engender aberrant …

Extracellular Vesicles And Cancer Therapy: An Insight Into The Role Of Oxidative Stress, Jenni Ho

Theses and Dissertations--Toxicology and Cancer Biology

As a result of improvements in cancer detection and treatment methods, a growing population of cancer survivors are living with side effects associated with their cancer therapy. Oxidative stress plays a significant role in the development of cancer and as a mechanism for cancer therapy to exert its therapeutic effects, resulting in off-target tissue damage. Radiation has been long established as a means to utilize the generation of reactive oxygen species to kill cancer cells, and 50% of chemotherapy agents currently used are associated with inducing oxidative stress. One major side effect observed in cancer survivors is a decline in …

Mujer Y Discurso Empresarial: El Caso De Las Publicaciones Para Las Mujeres Empresarias/Emprendedoras, Yanira B. Paz

Hispanic Studies Faculty Publications

Michelle Lazar (2006) acuña bajo el término “power femininity” una suerte de postfeminismo light orientado hacia el consumo y los medios. El mismo supone una forma de discurso popular global que incorpora contenidos de emancipación y empoderamiento de la mujer, aunque –en realidad—resulta en un tipo de feminismo vaciado de su contenido político. Este artículo se propone analizar la representación de la mujer empresaria/emprendedora mediante el estudio de las características del discurso (multimodal) en cuatro revistas impresas y digitales dirigidas a este tipo de mujeres y decidir si responde a la expresión de un feminismo que asume el empoderamiento de …

Exploring The Relationship Between Place Attachment And Attitudes Toward Tourism Development In Powell County, Lindsay Vance

Theses and Dissertations--Community & Leadership Development

This study explores the relationship between Powell County, Kentucky residents’ place attachment, and the perceived sociocultural, environmental, and financial benefits of the future Warrior’s Path development. A survey consisting primarily of five-point Likert scale questions was shared with several local organizations to distribute to their members. The Pearson’s correlation coefficient and Chi-square test of independence tests were used to discover any correlation between place attachment and perceived sociocultural, environmental, and financial benefits of tourism development. The Pearson’s correlation coefficient (r=.465) determined a moderate positive correlation between place attachment and perceived sociocultural benefits of the Warrior’s Path and tourism development. Of …

Use Of Heterothallic Mat Deletion Strains Of Fusarium Graminearum As Test Mates In Crosses To Evaluate The Genetics Of Pathogenicity And Fitness, Gabdiel Emmanuel Yulfo-Soto

Theses and Dissertations--Plant Pathology

Fusarium Head Blight (FHB), caused by Fusarium graminearum sensu stricto and other members of the F. graminearum species complex (FGSC), is a plant disease that occurs on cereal crops worldwide. FHB causes yield losses not only by reducing grain weight, but also by contaminating the kernels with dangerous trichothecene mycotoxins, especially deoxynivalenol (DON). There is a high degree of genotypic and phenotypic variation among pathogen species and strains, but current FHB risk assessment models and treatments do not account for pathogen diversity. Therefore, it is difficult to predict what will happen if a new, potentially more aggressive variant is introduced, …

Large-Scale Modeling And Dr Control Of Electric Water Heaters With Energy Star And Cta-2045 Control Types In Distribution Power Systems, Huangjie Gong, Evan S. Jones, A. H. M. Jakaria, Aminul Huque, Ajit Renjit, Dan Ionel

Power and Energy Institute of Kentucky Faculty Publications

The paper proposes a generalized energy storage (GES) model for battery energy storage systems (BESS), electric water heaters (EWH) and heating, ventilation, and air-conditioning (HVAC) systems to enable demand response control complying to Energy Star and CTA-2045 standards. The demand response control has been implemented in the DER integration testbed, which was originally developed by EPRI, to demonstrate that the “energy content” and “energy take” for BESS and EWH with mixing valve technology are comparable for typical residential ratings. A distribution power system was modeled using the modified IEEE 123-bus feeder system, measured residential loads, and EWH power simulated based …

Multi-Physics And Artificial Intelligence Models For Digital Twin Implementations Of Residential Electric Loads, Steven Poore, Rosemary E. Alden, Huangjie Gong, Dan M. Ionel

Power and Energy Institute of Kentucky Faculty Publications

Heating, ventilation, and air-conditioning (HVAC) and electric water heating (EWH) represent residential loads. Simulating these appliances for electric load forecasting, demand response (DR) studies, and human behavior analysis using physics-based models and artificial intelligence (AI) can further advance smart home technology. This paper explains the background of residential load modeling, starting with the concept of digital twin (DT) as well as the different types of methods. Two major types of appliance load monitoring (ALM) and their advantages/disadvantages are then discussed. This is followed by a review of multiple studies on residential load modeling, particularly for HVAC, EWH, and human behavior. …

The Clean Water Act And The Ocean: An Unfulfilled Promise, Robin Kundis Craig

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

“Don’T Feel Like You Have To Do This All On Your Own”: Exploring Perceived Partner Support Of Breastfeeding Among Black Women In Kentucky, Jardin Dogan

Theses and Dissertations--Educational, School, and Counseling Psychology

Background: Partner support improves breastfeeding initiation and continuation among mothers. However, few studies have explored partner support for breastfeeding among Black women living in the southeastern U.S., who report the lowest rates nationally of breastfeeding compared to women of other racial groups. Ways to increase support of Black women’s breastfeeding may be best understood from an Afrocentric perspective.

Research Aim: This qualitative study aimed to explore perceptions of partner support among Black mothers to abductively develop a culturally relevant framework of partner support to improve their rates of breastfeeding. Our research question was, “What partner support behaviors do Black …

Countercode: Bodies Un-Becoming, Aaron Reynolds

Graduate Thesis Exhibition Catalogue Gallery, 2022

In COUNTERCODE: BODIES UN-BECOMING, my intent is not to present a cohesive map or identify a single, primary mode of resistance. Rather, the five artists I have selected —Shana Moulton, Cooper Gibson, Amy Yeager, Jazmine Morris, and Clara Wouters—explore the socio-cultural implications of identity expression and persona play, particularly as it relates to the encoding of subjectivity in contemporary forms of digital media and pop culture. Their works glitch codes, find slippages, and create opacities in the fabric of capitalist realism, a term used by theorist Mark Fisher to describe the widespread acceptance of capitalism as the only viable economic …

Tangled Roots: Exploring Appalachian Feminisms, Magenta Palo

Graduate Thesis Exhibition Catalogue Gallery, 2022

Women have long been overlooked as key figures in the cultural history of Appalachia. The exhibition Tangled Roots: Exploring Appalachian Feminisms seeks to examine the ways in which women artists across the region have kept traditions alive while redefining creative practices that were once seen strictly as “women’s work.” In particular, the exhibition aims to explore how women have reimagined “craft” through skillful attention to materials, manual dexterity, and application of critical and conceptual rigor. The concept of craft is defined in this context to include all hand-made work that requires developed skills, whether they belong to traditional craft-based practices …