Digital Commons Network^™

A Study On Motivators And Satisfaction In Arts And Culture Public Programs: Implications For Policy Implementation, Eunyoung Yi

MPA/MPP/MPFM Capstone Projects

This study examines individuals’ motivations related to their participation in arts and culture activity programs and their support for the active roles of the government in cultivating such programs in South Korea. In doing so, this study suggests policy implications that help policymakers and stakeholders develop effective arts and culture programs in the public sector.

This study claims that redesigning the program contents reflecting sociopsychological motivations, expanding the policy target to the general public, and embracing the concept of lifelong arts and culture education will ensure inclusive accessibility and promote lifelong learning opportunities for all citizens.

Guided by intrinsic and …

Towards Smart Cities As Innovation Systems: The Case Of Macau Sar, Yujia He

Patterson School of Diplomacy and International Commerce Faculty Publications

Smart cities are emerging as major engines for deploying intelligent systems to enhance urban development and contribute to the UN 2030 Sustainable Development Goals. The rise of smart city initiatives is not only seen in North America and Europe but also increasingly in Asia and across the developing world which faces rapid urbanization and technological change. Home to the UNU Institute in Macau, the city of Macau is a special administrative region (SAR) of China where “the East meets the West” in local governance, economy, and society. Our research article, recently published in the Journal of Urban Affairs, …

And The Survey Says ... A Qualitative Exploration Of Structurational Divergence From The Perspectives Of Nurse Managers Who Are Accountable For Patient Experience Measures, Lisa Carpenter Huddleston

Theses and Dissertations--Communication

For more than a decade, hospital leaders have focused on boosting patient experience scores as part of the federal government’s value-based purchasing (VBP) program. Hospitals that receive federal financial assistance (such as Medicare) are mandated to participate in the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS), a standardized survey that measures patients’ perceptions of their care. Results are publicly reported, and hospitals may be penalized on their reimbursements if they do not reach established benchmarks for patient experience. However, much debate has occurred about whether VBP has increased the quality of healthcare and whether the HCAHPS is an …

Multi-Omic Analysis Of Vegetative Propagation Induced Plant Rejuvenation In Grapevines: Implications For The Generation Of Locally Adapted Cultivars Using Epigenetics, Tajbir Raihan

Theses and Dissertations--Plant and Soil Sciences

Epigenetic memory of the growing environment is a process capable of increasing plants’ resilience to abiotic stimuli. The cultivated grapevine is a long-living perennial species with a large corpus of research suggesting that plant adaptation to the environment has implications for the selection of genetic material in a changing climate. Moreover, vine age has been traditionally correlated with enhanced fruit quality. Recent studies have shown that environment/age-acquired traits in grapevine (e.g., adaptation to the growing environment and fruit/wine quality, respectively) are associated with epigenetic mechanisms. These studies also indicate that of propagation type affects the maintenance/erasure of the acquired traits …

Mapping Landslide Susceptibility Over Large Regions With Limited Data, J. B. Woodard, Benjamin B. Mirus, Matthew M. Crawford, D. Or, B. A. Leshchinsky, K. E. Allstadt, N. J. Wood

Faculty, Staff, and Affiliated Publications--KGS

Landslide susceptibility maps indicate the spatial distribution of landslide likelihood. Modeling susceptibility over large or diverse terrains remains a challenge due to the sparsity of landslide data (mapped extent of known landslides) and the variability in triggering conditions. Several different data sampling strategies of landslide locations used to train a susceptibility model are used to mitigate this challenge. However, to our knowledge, no study has systematically evaluated how different sampling strategies alter a model's predictor effects (i.e., how a predictor value influences the susceptibility output) critical to explaining differences in model outputs. Here, we introduce a statistical framework that examines …

Can Testing The Environment For Severe Acute Respiratory Coronavirus Virus 2 (Sars-Cov-2) Be A Signal For Coronavirus Disease 2019 (Covid-19) Cases Among Nursing Home Staff?, Gabrielle M. Gussin, Raveena D. Singh, Izabela Coimbra Ibraim, Raheeb Saavedra, Thomas T. Tjoa, Micaila Curtis, Kristine P. Nguyen, Ilhem Messaoudi, Susan S. Huang

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Prior to widespread COVID-19 vaccination, nursing homes were required to perform comprehensive weekly testing of staff. After the vaccine became available, testing became symptom-based for vaccinated staff despite continued waves of different severe acute respiratory coronavirus virus 2 (SARS-CoV-2) variants. Nursing homes need pragmatic, affordable strategies to identify SARS-CoV-2–positive staff because financial and job-related pressures drive reluctance to disclose mild symptoms. We sought to determine whether positive environmental samples for SARS-CoV-2 could serve as trigger for comprehensive staff testing in lieu of weekly testing of all staff.

Correlates Of Sars-Cov-2 Anti-Rbd Igg Antibody Titers Among Persons Experiencing Homelessness In Los Angeles, Adeline Nyamathi, Sanghyuk S. Shin, Brianna M. Doratt, Alexandria Jones-Patten, Benissa Salem, Lillian Gelberg, Darlene Lee, Dana Garfin, Kartik Yadav, Alicia H. Chang, Kathryn White, Nicholas Arce, Ilhem Messaoudi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Objectives: People experiencing homelessness (PEH) have been especially impacted by the COVID-19 pandemic, likely due to increased vulnerabilities stemming from chronic diseases, substance use, and mental health conditions.

Design: A case–control study to assess the presence of antibodies against SARS-CoV-2 among PEH and associations with key variables.

Sample: A convenience sample of 97 PEH in Skid Row, Los Angeles.

Measurements: A structured questionnaire assessing socio-demographic, mental health, drug and alcohol use, health care access, pandemic stress, and other COVID-19-specific questions.

Results: We found high anti-receptor binding domain (RBD) IgG titers among five of 15 PEH who reported no prior COVID-19 …

Maternal Obesity Blunts Antimicrobial Responses In Fetal Monocytes, Suhas Sureshchandra, Brianna M. Doratt, Norma Mendza, Oleg Varlamov, Monica Rincon, Nicole E. Marshall, Ilhem Messaoudi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Maternal pre-pregnancy (pregravid) obesity is associated with adverse outcomes for both mother and offspring. Amongst the complications for the offspring is increased susceptibility and severity of neonatal infections necessitating admission to the intensive care unit, notably bacterial sepsis and enterocolitis. Previous studies have reported aberrant responses to LPS and polyclonal stimulation by umbilical cord blood monocytes that were mediated by alterations in the epigenome. In this study, we show that pregravid obesity dysregulates umbilical cord blood monocyte responses to bacterial and viral pathogens. Specifically, interferon-stimulated gene expression and inflammatory responses to respiratory syncytial virus (RSV) and E. coli were significantly …

Single-Dose Vsv-Based Vaccine Protects Cynomolgus Macaques From Disease After Taï Forest Virus Infection, Paige Fletcher, Kyle L. O'Donnell, Brianna M. Doratt, Delphine C. Malherbe, Chad S. Clancy, Joseph F. Rhoderick, Friederike Feldmann, Patrick W. Hanley, Thomas G. Ksiazek, Thomas W. Geisbert, Ilhem Messaoudi, Andrea Marzi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Taï Forest virus (TAFV) is a lesser-known ebolavirus that causes lethal infections in chimpanzees and is responsible for a single human case. Limited research has been done on this human pathogen; however, with the recent emergence of filoviruses in West Africa, further investigation and countermeasure development against this virus is warranted. We developed a vesicular stomatitis virus (VSV)-based vaccine expressing the TAFV glycoprotein as the viral antigen and assessed it for protective efficacy in nonhuman primates (NHPs). Following a single high-dose vaccination, NHPs developed antigen-specific binding and neutralizing antibodies as well as modest T cell responses. Importantly, all vaccinated NHPs …

Platelet Glycogenolysis Is Important For Energy Production And Function, Kanakanagavalli Shravani Prakhya, Hemendra J. Vekaria, Daniёlle M. Coenen, Linda Omali, Joshua Lykins, Smita Joshi, Hammodah Rawhi Hammodah Alfar, Qing Jun Wang, Patrick G. Sullivan, Sidney W. Whiteheart

Saha Cardiovascular Research Center Faculty Publications

Although the presence of glycogen in platelets was established in the 1960s, its importance to specific functions (i.e., activation, secretion, aggregation, and clot contraction) remains unclear. Patients with glycogen storage disease often present with increased bleeding and glycogen phosphorylase (GP) inhibitors, when used as treatments for diabetes, induce bleeding in preclinical studies suggesting some role for this form of glucose in hemostasis. In the present work, we examined how glycogen mobilization affects platelet function using GP inhibitors (CP316819 and CP91149) and a battery of ex vivo assays. Blocking GP activity increased glycogen levels in resting and thrombin-activated platelets and inhibited …

Lrp1 Protects Against Excessive Superior Mesenteric Artery Remodeling By Modulating Angiotensin Ii–Mediated Signaling, Jackie M. Zhang, Dianaly T. Au, Hisashi Sawada, Michael K. Franklin, Jessica J. Moorleghen, Deborah A. Howatt, Pengjun Wang, Brittany O. Aicher, Brian Hampton, Mary Migliorini, Fenge Ni, Adam E. Mullick, Mashhood M. Wani, Areck A. Ucuzian, Hong S. Lu, Selen C. Muratoglu, Alan Daugherty, Dudley K. Strickland

Saha Cardiovascular Research Center Faculty Publications

Vascular smooth muscle cells (vSMCs) exert a critical role in sensing and maintaining vascular integrity. These cells abundantly express the low-density lipoprotein receptor–related protein 1 (LRP1), a large endocytic signaling receptor that recognizes numerous ligands, including apolipoprotein E–rich lipoproteins, proteases, and protease-inhibitor complexes. We observed the spontaneous formation of aneurysms in the superior mesenteric artery (SMA) of both male and female mice in which LRP1 was genetically deleted in vSMCs (smLRP1–/– mice). Quantitative proteomics revealed elevated abundance of several proteins in smLRP1–/– mice that are known to be induced by angiotensin II–mediated (AngII-mediated) signaling, suggesting that this pathway was dysregulated. …

Macrophage Angiotensin-Converting Enzyme Reduces Atherosclerosis By Increasing Peroxisome Proliferator-Activated Receptor Α And Fundamentally Changing Lipid Metabolism, Duoyao Cao, Zakir Khan, Xiaomo Li, Suguru Saito, Ellen A. Bernstein, Aaron R. Victor, Faizan Ahmed, Aoi O. Hoshi, Luciana C. Veiras, Tomohiro Shibata, Mingtian Che, Lei Cai, Michifumi Yamashita, Ryan E. Temel, Jorge F. Giani, Daniel J. Luthringer, Ajit S. Divakaruni, Derick Okwan-Duodu, Kenneth E. Bernstein

Saha Cardiovascular Research Center Faculty Publications

Aims The metabolic failure of macrophages to adequately process lipid is central to the aetiology of atherosclerosis. Here, we examine the role of macrophage angiotensin-converting enzyme (ACE) in a mouse model of PCSK9-induced atherosclerosis.

Methods and results Atherosclerosis in mice was induced with AAV-PCSK9 and a high-fat diet. Animals with increased macrophage ACE (ACE 10/10 mice) have a marked reduction in atherosclerosis vs. WT mice. Macrophages from both the aorta and peritoneum of ACE 10/10 express increased PPARα and have a profoundly altered phenotype to process lipids characterized by higher levels of the surface scavenger receptor CD36, increased uptake of …

Investigating Visinin-Like Protein 1 And Ubiquitinated Visinin-Like Protein 1 As Mild Traumatic Brain Injury Biomarkers, Yueming Wu

Theses and Dissertations--Chemistry

Traumatic brain injury (TBI) continues to be a significant cause of morbidity and mortality worldwide. Despite significant progress in understanding the complex pathophysiology of TBI, the underlying mechanisms remain poorly understood. The primary brain damage is acute and irreversible. However, secondary brain injuries often develop gradually over months to years, creating an opportunity for critical therapeutic interventions. In the past decade, research on TBI biomarkers has seen significant progress. This progress has been driven by the diverse nature of TBI pathologies and the challenges they present for evaluation, management, and prognosis. TBI biomarker proteins resulting from axonal, neuronal, or glial …

“Thinking Across Bodies”: Percepción Woolfiana Y Giro Material En La Cuentística De Rodoreda, Roig, Alós Y Riera, Ana Álvarez Guillén

Theses and Dissertations--Hispanic Studies

Conventional understandings of perception have long undergirded traditional readings of Modernist texts in adopting a predominantly subject-centered perspective that separates subject from object in a vertical and hierarchical relationship. I argue that a consideration of Virginia Woolf’s short stories in dialogue with four generations of twentieth-century Catalan women writers who followed her work closely suggests an entirely different epistemological framework of perception in which subject and object are fluidly and horizontally organized. Mercè Rodoreda, Concha Alós, Montserrat Roig and Carme Riera establish a horizontal fictional dialogue that constitutes a return to matter that decenters the subject, resulting in an alternative …

Navigating The Maze Of Student Loan Debt: Exploring Long-Term Economic Implications And Strategies For Alleviating The Burden, Kimberly Faulk

MPA/MPP/MPFM Capstone Projects

This capstone paper explores the long-term economic implications of student loan debt on individuals and society and identifies potential strategies that can be implemented to alleviate the burden. Student loan debt has become a significant issue globally, affecting individuals of all backgrounds and having far-reaching consequences for both individuals and the broader economy. The analysis reveals that the long-term economic implications of student loan debt on individuals are multifaceted. High levels of debt can hinder financial stability and economic mobility, as borrowers struggle to save, invest, and participate in the broader economy. The burden of student loan debt can delay …

Bourbon Barrel Tax, William Twigg

MPA/MPP/MPFM Capstone Projects

This paper will look at the impacts of barrel tax reform within the state of Kentucky and the impact of the sunsetting of such an important revenue generator for the Commonwealth given the recent passing of Kentucky House Bill 5 (HB5) on March 31, 2023. It will provide a brief history of the bourbon industry, how Kentucky became known as the homeland of bourbon, some background as to what the barrel tax is and why the tax was needed in the first place, and provide some context as to how the tax was assessed, how much it amounted to, and …

Musical Portraiture In Acht Korte Karakterschetsen Voor Piano Vierhandig By Hans Osieck, Yuri Kim

Theses and Dissertations--Music

Hans Osieck (1910-2000) was a Dutch composer, pianist, and teacher. His musical portraits, Acht Korte Karakterschetsen voor piano vierhandig (Eight Short Character Sketches for Four Hands), are a valuable addition to the piano duo repertoires for intermediate and advanced students. In Eight Sketches, Osieck musically portrays eight of his students using simple compositional techniques, much like the brushstrokes and color palette of an artistic portrait. As a result of their programmatic nature and relatable subjects, Osieck’s Eight Sketches can be particularly useful for students developing their imaginations and learning to perform expressively. As a piano duo, Eight Sketches also serves …

Opportunities For Cantabile Performance In Seung Ki Hong’S Arirang Variations, Hye Jin Yeom

Theses and Dissertations--Music

The purpose of this project is introducing South Korean composer Seung Ki Hong’s Arirang Variations (2015). Hong’s post-2013 work has focused on incorporating traditional Korean melodies into Western instrumental music; Arirang Variations exemplifies this process. The theme is “Arirang,” a folksong that Koreans have sung to express their joys and sorrows for centuries. Hong transforms this iconic melody through a series of variations in various dance styles such as a tango and a Viennese waltz.

This paper includes two main sections. The first provides background information that, although important for understanding Arirang Variations, is inaccessible to many performers. This section …

Julie Giroux’S Symphony No. 6: The Blue Marble Background, Analysis, And Conductor’S Guide, Josh Gillen

Theses and Dissertations--Music

Julie Giroux’s Symphony No. 6: The Blue Marble (2022) is an original work for wind band that is quickly rising in popularity among instrumental conductors and ensembles throughout the world. The purposes of this document are to

1) provide biographical details regarding Julie Giroux and her musical career;

2) provide a background of the work’s conception from a musical and multi-media perspective through interviews with Giroux and the first conductors of the work;

3) provide a multi-parametric structural analysis of the work and its companion film;

4) provide conductors with useful information for programming and rehearsing the work.

Chapter one …

The Yi Cycle: Finding The ‘Existing’ And ‘Potential’ In Tan Dun’S Intercourse Of Fire And Water For Cello Solo, Kevin He

Theses and Dissertations--Music

The Chinese American composer Tan Dun was born in 1957 in the Hunan province of China. His early life reflected the difficulties of being a student during the Cultural Revolution. Tan Dun’s Intercourse of Fire and Water for Cello Solo reflects the composer’s journey from China to the USA in the aftermath of the Cultural Revolution. The piece is the first solo concerto originating from Dun’s Yi0: Concerto for Orchestra, which was written in 2002 and is based on the ancient Chinese book I Ching (Book of Changes). The Yi Cycle includes four works: Yi0: Concerto for …

The Exploration Of Clinical Wisdom Of Music Therapists Working With Adults With Severe And Profound Intellectual Disability: A Multiple Case Study, Courtney Catron

Theses and Dissertations--Music

Research on the severe and profound intellectually disabled adult population is sparse due to several factors including difficulty in acquiring consent for research, lack of funding, and difficulty in interpreting behavioral responses. Music therapists providing services to this population are faced with sparse resources to guide evidence-based practice with severe and profound intellectually disabled (ID) adults. It is vital to document how seasoned professionals work with this population effectively to improve the evidence base for music therapists. This project used a multiple case study approach. Four music therapists provided an in-depth exploration of their clinical wisdom from years of working …

Gesture And The Auditory Impact On The Perception Of Sound: A Performance Guide For Understanding Gestural Function On Percussion Pedagogy And Performance, Emily Lane Durocher

Theses and Dissertations--Music

I will address the concept of physical gestures and discuss how they are applicable to the way percussionists visually and audibly perceive music. Through my research, I will focus on performance and pedagogy, seeking new possibilities for introducing percussionists at all ability levels to different articulations. Percussionists have traditionally been led to believe that they do not have the versatility over the initial musical attack and sustain that wind and string players do. This document has been developed to provide a more in-depth approach to how physical and musical gestures can function to create a more versatile and musical percussionist. …

“Songs Of The Underground” – Crafting A Unique Gaming Experience Through Music, Megan Franklin

Theses and Dissertations--Music

The academic study of video game music, known as Ludomusicology, is a younger research area in the world of musicology, with the earliest works having been published in the late 80’s and early 90’s. Despite its young age, Ludomusicology is becoming a staple in the academic world, with scholars such as Melanie Fritsch, Andra Ivănescu, Michiel Kamp, Tim Summers, and Mark Sweeney dedicating their time to the subject. This thesis uses musical analysis as the basis of exploring the relationship between music and aspects of video game creation and player interaction. The case study for this project is the 2015 …

Sugar And Spice: Sex, Money, And Social Media, Rachel Elizabeth Davis

Theses and Dissertations--Sociology

Interest in transactional sex, or the provision of a sexual relationship in exchange for gifts and/or money, has increased in recent years among researchers, nongovernmental organizations, and law enforcement officials as increasing numbers of women self-identify as hypergamous, indicating their interest in forming heterosexual partnerships with men of higher status. Hypergamous women may identify as sugar babies, spoiled girlfriends, or high-value women. A sugar baby is a woman providing romantic companionship to an older man, known as a sugar daddy, in exchange for money and/or gifts. A spoiled girlfriend is a woman whose partner provides her with money and/or gifts …

Let's Not Do Anything Drastic: Processes Of Reproducing Rural Marginalization In Education Policy Decision-Making, Julia M. Miller

Theses and Dissertations--Sociology

At a school board meeting in micropolitan Athens County, parents of children attending the district’s smallest elementary school, Chauncey Elementary, packed in to defend the school against consolidation. They made calls for a levy to cover the impending budget shortfall and offered to reduce their classrooms by half if other schools would also bear some of the costs. They spent their holiday season defending their school, a source of vibrancy in the small town, from being closed. In the meeting, someone advocating for alternatives to closure suggested cutting administrator positions. The board response, according to one parent-leader? “Let’s not do …

A Characterization Of Key Residues In Class I Viral Fusion Proteins Important For Fusogenic Activity, Hadley E. Neal

Theses and Dissertations--Molecular and Cellular Biochemistry

Viral fusion proteins are critical for viral entry and subsequent infection. Class I fusion proteins are characterized by synthesis as an inactive precursor requiring cleavage by a host cell protease to become fusion competent. Though vaccine and antiviral therapeutic developments often target the fusion protein, questions surrounding cleavage dynamics and protein stability remain. The work presented in this dissertation investigates specific regions of three class I viral fusion proteins in an effort to identify key residues involved in proteolytic processing and membrane fusion.

The trimeric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (S) mediates receptor binding, facilitates fusion …

Polycomb Deficiency Drives A Foxp2-High Aggressive State Targetable By Epigenetic Inhibitors, Fan Chen, Aria Byrd, Jinpeng Liu, Robert M. Flight, Tanner Ducote, Kassandra J. Naughton, Xiulong Song, Abigail R Edgin, Alexsandr Lukyanchuk, Danielle T. Dixon, Christian M. Gosser, Dave-Preston Esoe, Rani Jayswal, Stuart H. Orkin, Hunter N. B. Moseley, Chi Wang, Christine Fillmore Brainson

Markey Cancer Center Faculty Publications

Inhibitors of the Polycomb Repressive Complex 2 (PRC2) histone methyltransferase EZH2 are approved for certain cancers, but realizing their wider utility relies upon understanding PRC2 biology in each cancer system. Using a genetic model to delete Ezh2 in KRAS-driven lung adenocarcinomas, we observed that Ezh2 haplo-insufficient tumors were less lethal and lower grade than Ezh2 fully-insufficient tumors, which were poorly differentiated and metastatic. Using three-dimensional cultures and in vivo experiments, we determined that EZH2-deficient tumors were vulnerable to H3K27 demethylase or BET inhibitors. PRC2 loss/inhibition led to de-repression of FOXP2, a transcription factor that promotes migration and stemness, and FOXP2 …

Nitrogen Behavior In A No-Tillage Agroecosystem Located In The Inner Bluegrass Of Kentucky, Alec William Besinger Mr.

Theses and Dissertations--Plant and Soil Sciences

Nitrogen (N) is a crucial element, often limiting productivity in ecosystems. This limitation is relieved N fertilizer additions. No-tillage (NT) agroecosystems are prone to lower N availability translating to lower crop yields. The default explanation for lower N availability in NT is microbial immobilization of added N fertilizer. Historically, N availability is often assessed using chemical extractions such as KCl to evaluate levels of inorganic N in the soil. The possibility of this abiotic clay mineral fixation as mechanism in well-drained NT soils has been overlooked. The objectives of this study are to quantify N availability using KCl, NaCl, and …

Identification And Removal Of Barriers To Va Mental Health Treatment For Black Female Veterans, Thea Jenune Williams

DSW Capstone Projects

The Department of Veteran Affairs (VA) operates the largest integrated health care system in the country. The VA dates back to 1865, when President Lincoln signed legislature establishing a network for caring for the nation’s wounded after the Civil War. Many see this system as a safety net for the nation’s military veterans. Research shows veterans have reported several factors that interfere with them receiving needed mental health treatment from the VA. The majority of veterans are males however the number of females is quickly growing. Currently, females make up 11% of the veteran population and are projected to reach …

Black Women And The Weight Of The World: When The Weight Becomes Too Much To Bear, April R. Edmonds

DSW Capstone Projects

ABSTRACT

Black women’s mental health continues to go largely underrepresented. Black women are seen as having many protective factors such as their faith communities, family and friends, and what others see as strength and resilience. A review of the literature depicts Black women as traditionally being caretakers, nurturers, and depicted as strong (Castelin & White, 2022). Because of this perception, terms such as the Strong Black Woman Schema and the Black Superwoman Phenomena are what many equate Black women with. This scholarship instead shows how associations such as these impact Black women negatively and impose additional stigma and hardship. Research …