Digital Commons Network^™

The Effect Of Student Mobility On Student Achievement, Lisa Eddy

University of Kentucky Doctoral Dissertations

Student mobility and its relationship to academic success have been researched since World War II with varied findings (Goebel, 1978). Establishing the relationship between mobility and achievement is difficult due to the fact that mobility is related to many factors. Mobility has been found to be prevalent among students who traditionally demonstrate achievement gaps (specifically students of low-income status) (Long, 1992; Smith, Fien & Paine, 2008).

Mobility’s relationship to achievement is complex. Led by a single definition of mobility, admittance to more than one school in the given district over the period of one academic year, this research study sought …

Engineering Proteins With Unique Characteristics For Diagnostics And Biosensors, Smita Joel

University of Kentucky Doctoral Dissertations

Proteins possess a broad range of structural and functional properties and, therefore, can be employed in a variety of biomedical applications. While a good number of protein-based biosensing systems and biosensors for target analytes have been developed, the search for versatile, highly sensitive and selective sensors with long term stability able to provide fast detection of target analytes continues to be a challenge. To that end, we now report the design and development of modified proteins with tailored characteristics and their further utilization in the development of biosensing systems.

We take advantage of binding proteins that undergo a change in …

Development Of Luminescent Sensing Systems With Clinical Applications, Daniel F. Scott

University of Kentucky Doctoral Dissertations

As the move towards the miniaturization of many diagnostic and detection systems continues, the need for increasingly versatile yet sensitive labels for use in these systems also grows. Luminescent reporters provide us with a solution to many of the issues at hand through their unique and favorable characteristics. Bioluminescent proteins offer detection at extremely low concentrations and no interference from physiological fluids leading to excellent detection limits, while the vast number of fluorescent proteins and molecules available allows the opportunity to select a tailored reporter for a specific task. Both provide relatively simply instrumentation requirements and have exhibited great promise …

Atomic Force Microscopy Method Development For Surface Energy Analysis, Clare Aubrey Medendorp

University of Kentucky Doctoral Dissertations

The vast majority of pharmaceutical drug products are developed, manufactured, and delivered in the solid-state where the active pharmaceutical ingredient (API) is crystalline. With the potential to exist as polymorphs, salts, hydrates, solvates, and cocrystals, each with their own unique associated physicochemical properties, crystals and their forms directly influence bioavailability and manufacturability of the final drug product. Understanding and controlling the crystalline form of the API throughout the drug development process is absolutely critical. Interfacial properties, such as surface energy, define the interactions between two materials in contact. For crystal growth, surface energy between crystal surfaces and liquid environments not …

The Application Of Discontinuous Galkerin Finite Element Time-Domain Method In The Design, Simulation And Analysis Of Modern Radio Frequency Systems, Bo Zhao

University of Kentucky Doctoral Dissertations

The discontinuous Galerkin finite element time-domain (DGFETD) method has been successfully applied to the solution of the coupled curl Maxwell’s equations. In this dissertation, important extensions to the DGFETD method are provided, including the ability to model lumped circuit elements and the ability to model thin-wire structures within a discrete DGFETD solution. To this end, a hybrid DGFETD/SPICE formulation is proposed for high-frequency circuit simulation, and a hybrid DGFETD/Thin-wire formulation is proposed for modeling thin-wire structures within a three-dimensional problem space. To aid in the efficient modeling of open-region structures, a Complex Frequency Shifted-Perfectly Matched Layer (CFS-PML) absorbing medium is …

Modeling, Analysis, And Simulation Of Discrete-Continuum Models Of Step-Flow Epitaxy: Bunching Instabilities And Continuum Limits, Nicholas O. Kirby

University of Kentucky Doctoral Dissertations

Vicinal surfaces consist of terraces separated by atomic steps. In the step-flow regime, deposited atoms (adatoms) diffuse on terraces, eventually reaching steps where they attach to the crystal, thereby causing the steps to move. There are two main objectives of this work. First, we analyze rigorously the differences in qualitative behavior between vicinal surfaces consisting of infinitely many steps and nanowires whose top surface consists of a small number of steps bounded by a reflecting wall. Second, we derive the continuum model that describes the macroscopic behavior of vicinal surfaces from detailed microscopic models of step dynamics.

We use the …

Circadian And Homeostatic Regulation Of Sleep In Cast/Eij And C57bl/6j Mice, Peng Jiang

University of Kentucky Doctoral Dissertations

Sleep is essential for mammals and possibly for all animals. Advancing our knowledge of sleep regulation is crucial for the development of interventions in sleep-related health and social problems. With this aim, this study utilizes laboratory mice to explore sleep regulatory mechanisms at behavioral, molecular, and genetic levels.

Sleep is regulated by the interaction of circadian and homeostatic processes. The circadian clock facilitates sleep to occur at a favorable time of the day. Normal mice, such as the C57BL/6J (B6) strain, sleep mostly during the day and initiate activities at dark onset. Here, I show mice of the CAST/EiJ (CAST) …

Structural Evolution Of An Intracratonic Rift System; Mississippi Valley Graben, Rough Creek Graben, And Rome Trough Of Kentucky, Usa, John Bibb Hickman Jr.

University of Kentucky Doctoral Dissertations

As indicated by drilling and geophysical data, the Mississippi Valley Graben, the Rough Creek Graben, together with the Rome Trough of eastern Kentucky and West Virginia, are fault-bounded graben structures filled with as much as 27,000 feet of Early to Middle Cambrian sediments. Detailed regional mapping of Cambrian and younger strata within and surrounding these structures indicates that they formed contemporaneously. The proximity of these structures suggests they developed within the same regional stress fields and tectonic environments. These three structures are mechanically and kinematically connected, and formed part of a single continent-scale rift system produced during the breakup of …

Studies On Silicon Nmr Characterization And Kinetic Modeling Of The Structural Evolution Of Siloxane-Based Materials And Their Applications In Drug Delivery And Adsorption, Jyotrhirmai Ambati

University of Kentucky Doctoral Dissertations

This dissertation presents studies of the synthetic processes and applications of siloxane-based materials. Kinetic investigations of bridged organoalkoxysilanes that are precursors to organic-inorganic hybrid polysilsesquioxanes are a primary focus. Quick gelation despite extensive cyclization is found during the polymerization of bridged silane precursors except for silanes with certain short bridges. This work is an attempt to characterize and understand some of the distinct features of bridged silanes using experimental characterization, kinetic modeling and simulation. In addition to this, the dissertation shows how the properties of siloxane- materials can be engineered for drug delivery and adsorption.

The phase behavior of polymerizing …

Synthesis And Energy Applications Of Oriented Metal Oxide Nanoporous Films, Qingliu Wu

University of Kentucky Doctoral Dissertations

This dissertation mainly addresses the synthesis of well-ordered mesoporous titania thin films by dip coating with PEO-PPO-PEO triblock copolymer surfactant template P123. Because P123 is composed of poly(ethylene oxide) [PEO] and poly(propylene oxide) [PPO] blocks, concentrations of ingredients are adjusted to tune the films’ wall thickness, pore size and mesophase. Structural changes are consistent with partitioning of species among PEO blocks, PPO blocks, and the PEO/PPO interface. Titanates localize near PEO and increase wall thickness (by 5 nm to 7 nm). Depending on aging temperature, PPG either swells the PPO cores (when it is hydrophobic) or introduces large (>200 …

Enhancements To The Modified Composite Pattern Method Of Structured Light 3d Capture, Charles Joseph Casey

University of Kentucky Doctoral Dissertations

The use of structured light illumination techniques for three-dimensional data acquisition is, in many cases, limited to stationary subjects due to the multiple pattern projections needed for depth analysis. Traditional Composite Pattern (CP) multiplexing utilizes sinusoidal modulation of individual projection patterns to allow numerous patterns to be combined into a single image. However, due to demodulation artifacts, it is often difficult to accurately recover the subject surface contour information. On the other hand, if one were to project an image consisting of many thin, identical stripes onto the surface, one could, by isolating each stripe center, recreate a very accurate …

Magnetic Shielding Studies For The Neutron Electric Dipole Moment Experiment At The Spallation Neutron Source, Susan Kate Malkowski

Theses and Dissertations--Physics and Astronomy

The neutron Electric Dipole Moment Experiment at the Spallation Neutron Source requires an overall magnetic shielding factor of order 10⁵ to attenuate external background magnetic fields. At present, the shielding design includes an external (room-temperature) multi-layer μ-metal magnetic shield, a cryogenic (4 Kelvin) Pb superconducting shield, and a cryogenic (4 Kelvin) ferromagnetic shield composed of Metglas ribbon. This research determined how to construct a Metglas shield using minimal material that produced axial and transverse shielding factors of ~267 and ~1500. In addition, the μ-metal and Metglas shields were modeled using finite element analysis. The FEA model includes external coils …

Artificial Neural Network Based Fault Location For Transmission Lines, Suhaas Bhargava Ayyagari

University of Kentucky Master's Theses

This thesis focuses on detecting, classifying and locating faults on electric power transmission lines. Fault detection, fault classification and fault location have been achieved by using artificial neural networks. Feedforward networks have been employed along with backpropagation algorithm for each of the three phases in the Fault location process. Analysis on neural networks with varying number of hidden layers and neurons per hidden layer has been provided to validate the choice of the neural networks in each step. Simulation results have been provided to demonstrate that artificial neural network based methods are efficient in locating faults on transmission lines and …

Effect Of A Silicon Tip On Absorption Cross Section, Field Enhancement, And Localized Surface Plasmon Resonance Of Different Sized Gold Nanoparticles Under Evanescent Wave Illumination, Gazi Mostafa Huda

University of Kentucky Master's Theses

We have numerically investigated the influence of a nanoscale silicon tip in proximity to an illuminated gold nanoparticle. We describe how the position of the high-permittivity tip and the size of a nanoparticle impact the absorption, peak electric field and surface plasmon resonance wavelength under different illumination conditions. We detail the finite element method (FEM) approach we have used for this, whereby we specify a volume excitation field analytically and calculate the difference between this source field and the total field (i.e., scattered-field formulation). We show that a nanoscale tip can locally enhance the absorption of the particle as well …

Modeling And Optimization To Evaluate Sustainability Performance Of Customizable Product Service Systems, Ken Harsha Tilakaratne Wijekoon

University of Kentucky Master's Theses

The aim of this thesis is to present a new methodology to evaluate and optimize sustainability of customizable product-service systems while ensuring economic, environmental and societal constraints are also satisfied. Activities across the total product lifecycle are considered to develop a model that evaluates closed-loop flow, while being monitored through the growth, maturity and decline stages of the product to provide a comprehensive analysis. A novel method to evaluate the customer satisfaction is also presented. The research considers a modular product where customization can be achieved by selecting from alternatives while ensuring the compatibility between these alternatives. A manufacturer will …

Cluster-Based Term Weighting And Document Ranking Models, Keerthiram Murugesan

University of Kentucky Master's Theses

A term weighting scheme measures the importance of a term in a collection. A document ranking model uses these term weights to find the rank or score of a document in a collection. We present a series of cluster-based term weighting and document ranking models based on the TF-IDF and Okapi BM25 models. These term weighting and document ranking models update the inter-cluster and intra-cluster frequency components based on the generated clusters. These inter-cluster and intra-cluster frequency components are used for weighting the importance of a term in addition to the term and document frequency components. In this thesis, we …

Evaluation Of The Physicochemical Properties And Stability Of Solid Lipid Nanoparticles Designed For The Delivery Of Dexamethasone To Tumors, Melissa Howard

University of Kentucky Doctoral Dissertations

Pre-clinical and clinical trials suggest that pre-treatment with dexamethasone (Dex) may facilitate enhanced uptake of subsequently administered chemotherapeutic agents. To reduce the side effects associated with systemic administration of Dex, solid lipid nanoparticles (SLNs) containing dexamethasone palmitate (Dex-P) were prepared as a means of achieving tumor-targeted drug delivery. These studies were aimed at evaluating the physicochemical properties and both the physiological and storage stability of the SLNs.

SLNs were prepared using nanotemplate engineering technology. Stearyl alcohol (SA) was used as the lipid phase with Brij^® 78 and Polysorbate 60 as surfactants and PEG6000 monostearate as a long-chain PEGylating agent. …

New Accurate Fault Location Algorithm For Parallel Transmission Lines, Pramote Chaiwan

University of Kentucky Doctoral Dissertations

Electric power systems have been in existence for over a century. Electric power transmission line systems play an important role in carrying electrical power to customers everywhere. The number of transmission lines in power systems is increasing as global demand for power has increased. Parallel transmission lines are widely used in the modern transmission system for higher reliability. The parallel lines method has economic and environmental advantages over single circuit. A fault that occurs on a power transmission line will cause long outage time if the fault location is not located as quickly as possible. The faster the fault location …

Computer Simulation Of A Hollow-Fiber Bioreactor: Heparan Regulated Growth Factors-Receptors Binding And Dissociation Analysis, Changjiang Zhang

University of Kentucky Doctoral Dissertations

This thesis demonstrates the use of numerical simulation in predicting the behavior of proteins in a flow environment.

A novel convection-diffusion-reaction computational model is first introduced to simulate fibroblast growth factor (FGF-2) binding to its receptor (FGFR) on cell surfaces and regulated by heparan sulfate proteoglycan (HSPG) under flow in a bioreactor. The model includes three parts: (1) the flow of medium using incompressible Navier-Stokes equations; (2) the mass transport of FGF-2 using convection-diffusion equations; and (3) the cell surface binding using chemical kinetics. The model consists of a set of coupled nonlinear partial differential equations (PDEs) for flow and …

Petrologic, Geochemical, And Geochronologic Constraints On The Tectonic Evolution Of The Southern Appalachian Orogen, Blue Ridge Province Of Western North Carolina, Eric Douglas Anderson

University of Kentucky Doctoral Dissertations

The Blue Ridge Province of western North Carolina contains a wide variety of metamorphosed igneous and sedimentary rocks that record the tectonic effects of Precambrian and Paleozoic orogenic cycles. Tectonic interpretations of the events that led to the present configuration are varied and often conflicting. This investigation examines metamorphosed mafic rocks that are widely interpreted to have formed during the closure of ocean basins. Metabasites, and specifically eclogites, have a tendency to mark tectonic sutures and frequently preserve pressure (P), temperature (T), and age data (t) that can be gleaned from mineral equilibria and U-Pb isotopic compositions. As such, the …

Fabrication And Characterization Of Mesoscale Protein Patterns Using Atomic Force Microscopy (Afm), Pei Gao

University of Kentucky Doctoral Dissertations

A versatile AFM local oxidation lithography was developed for fabricating clean protein patterns ranging from nanometer to sub-millimeter scale on octadecyltrichlorosilane (OTS) layer of Si (100) wafer. This protein patterning method can generate bio-active protein pattern with a clean background without the need of the anti-fouling the surface or repetitive rinsing.

As a model system, lysozyme protein patterns were investigated through their binding reactions with antibodies and aptamers by AFM. Polyclonal anti-lysozyme antibodies and anti-lysozyme aptamer are found to preferentially bind to the lysozyme molecules on the edge of a protein pattern before their binding to the interior ones. It …

Distal Radioulnar Joint Biomechanics And Forearm Muscle Activity, Joseph Scott Bader

University of Kentucky Doctoral Dissertations

Optimal management of fractures, post-traumatic arthritis and instability of the distal radioulnar joint (DRUJ) requires an understanding of the forces existing across this joint as a function of the activities of daily living. However, such knowledge is currently incomplete. The goal of this research was to quantify the loads that occur at the DRUJ during forearm rotation and to determine the effect that individual muscles have on those loads.

Human and cadaver studies were used to analyze the shear (A-P), transverse (M-L) and resultant forces at the DRUJ and to determine the role that 15 individual muscles had on those …

Interactions And Effects Of Biomolecules On Au Nanomaterial Surfaces, Manish Sethi

University of Kentucky Doctoral Dissertations

Au nanoparticles are increasingly being used in biological applications. Their use is of interest based upon their unique properties that are achieved at the nanoscale, which includes strong optical absorbances that are size and aggregation state dependent. Such absorbances can be used in sensitive chemical/biological detection schemes where bioligands can be directly attached to the nanoparticle surface using facile methods. Unfortunately, a number of complications persist that prevent their wide-scale use. These limitations include minimal nanoparticle stability in biological-based media of high ionic strength, unknown surface functionalization effects using simple biomolecules, and determining the binding motifs of the ligands to …

Resource Allocation And Efficient Routing In Wireless Networks, Jianjun Yang

University of Kentucky Doctoral Dissertations

In wireless networks, devices (nodes) are connected by wireless links. An important issue is to set up high quality (high bandwidth) and efficient routing paths when one node wants to send packets to other nodes. Resource allocation is the foundation to guarantee high quality connections. In addition, it is critical to handle void areas in order to set up detour-free paths. Moreover, fast message broadcasting is essential in mobile wireless networks. Thus, my research includes dynamic channel allocation in wireless mesh networks, geographic routing in Ad Hoc networks, and message broadcasting in vehicular networks.

The quality of connections in a …

Becoming Bodies: How Preadolescent Girls Consume And Produce Media In 21St Century America, Margaret Louise Mcgladrey

University of Kentucky Master's Theses

This study investigates preadolescent girls’ interpretations of images of and messages about women’s bodies presented in both traditional and online media in the American cultural context. Using qualitative methods including in-depth interviews, email diaries, and digital photo collages, this study gives voice to girls aged nine to eleven from diverse racial and socioeconomic backgrounds so that they might tell their stories about interacting with media that is relevant to their relationships with their bodies. Employing objectification theory as well as concepts from the cultural studies tradition, the findings suggest that the process of becoming a female body in the 21 …

Ethnic Identity And Perceived Discrimination As Predictors Of Academic Attitudes: The Mediating And Moderating Roles Of Psychological Distress And Self-Regulation, Hui Chu

University of Kentucky Master's Theses

The current study addressed the deficiency in research by examining risk factors for immigrant children that may lead to academic disengagement (such as ethnic discrimination by peers and teachers, and psychological distress) and resilience factors that promote academic engagement (such as the development of a positive ethnic identity). Children who had stronger, more positive ethnic identities had more positive academic attitudes. Furthermore, the more the children were teased by their peers and graded unfairly by their teachers because of their ethnicity, the more they thought school was less important, less useful and felt less efficacious about school and valued school …

Conceptualizing And Improving Red Wine Grape Cultivars Grown In Kentucky, Matthew Simson

University of Kentucky Master's Theses

Wine sensory attributes are associated with quality of wines. Cabernet Franc did not possess good coloration of its wine. Therefore, in the 2009 and 2010 growing seasons, studies including the sampling of four red wine grape cultivars from the end of flowering throughout the rest of the season and applying treatments to Cabernet Franc grapevines at veraison were commenced to address suitability and color enhancement, respectively. The study examining Cabernet Franc, Cabernet Sauvignon, Chambourcin, and Norton looked at sampling their grapes at two-week intervals from times post-flowering to understand the demands of each cultivar during key stages of berry development, …

“Obtuse Women”: Venereal Disease Control Policies And Maintaining A “Fit” Nation, 1920-1945, Evelyn Ashley Sorrell

University of Kentucky Master's Theses

Public health officials and social reformers grew concerned over the prevalence of gonorrhea and syphilis following World War I. The initiatives put in place by authorities to control the spread of venereal disease lacked any concern for women’s health and sought to control their newly found independence and mobility. This thesis examines public health policies related to venereal disease control from 1920-1945 and how these regulations affected women in the United States. Laws and social reform measures such as pre-marital blood tests, the Sheppard-Towner Maternity and Infancy Act, and the use of quarantining prostitutes during World War I and World …

Examining Gender Differences In Persistence In Higher Education Among African American Students, Yvonne Townsend

University of Kentucky Master's Theses

This Study examined issues related to persistence in higher education among African American students, using the prominent model proposed by Vincent Tinto. The intentions were to examine the growing gender gap among African American students. The study examines factors from the Tinto model such as high school GPA, College GPA, college social integration and academic integration to try and explain the effects of gender among African American students. This research also attempts to elaborate the Tinto model by considering high school extracurricular activities as a pre-entry attribute that has an effect on persistence in higher education. Use of the Tinto …

Analyzing Educational Attainments And Occupational Outcomes Of Tibetan Refugees Living In India, Tenzin Palkyi

University of Kentucky Master's Theses

Opportunities of mass education are a relatively new phenomenon in the Tibetan community. Following the incidents of 1959, the Dalai Lama and thousands of Tibetans fled into India. Mass education was implemented and sustained within the Tibetan community for the first time. The goal of this exploratory research is to study the impact of mass education on the first generations of Tibetans who experienced it in exile. This study analyzes the gendered pattern in subjects students choose to pursue, their educational attainment and the kinds of jobs they assume after graduation. The study presents a quantitative analysis of data spanning …