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Peripheral T-Cell Lymphoma With Aberrant Expression Of Cd19, Cd20, And Cd79a: Case Report And Literature Review, Rahul G. Matnani, Rachel L. Stewart, Joseph Pulliam, Chester D. Jennings, Melissa Kesler

Pathology and Laboratory Medicine Faculty Publications

A case of lymphoma of T-cell derivation with aberrant expression of three B-cell lineage markers (CD19, CD20, and CD79a), which was diagnosed on a left axillary excision, is described. Immunohistochemical studies and flow cytometry analysis demonstrated neoplastic cells expressing CD3, CD19, CD20, and CD79a with absence of CD4, CD8, CD10, CD30, CD34, CD56, CD68, TDT, MPO, PAX-5, and surface immunoglobulin. Gene rearrangement studies performed on paraffin blocks demonstrated monoclonal T-cell receptor gamma chain rearrangement with no evidence of clonal heavy chain rearrangement. The neoplastic cells were negative for Epstein-Barr virus (EBV) or Human Herpes Virus 8 (HHV-8). At the time …

Limetstone And Dolomite Resources Of Kentucky, Garland R. Dever Jr., Gerald A. Weisenfluh

Map and Chart--KGS

Large quantities of limestone and dolomite suitable for construction, agriculture, and industrial uses are available in Kentucky. Deposits of hard and durable stone are quarried and mined for construction. The stone is crushed to produce aggregate for concrete and asphalt used in the construction of highways, streets, and buildings. Much of the state’s stone being produced for construction also meets the chemical and physical specifications for aglime, which is used to adjust the pH of soils for agricultural crops and pastures. Deposits of chemically pure stone are used for the manufacture of lime and cement, and for industrial applications such …

Comparative Study Of Environmental Factors Influencing Motor Task Learning And Memory Retention In Sighted And Blind Crayfish, Sonya M. Bierbower, Zhanna P. Shuranova, Kert Viele, Robin L. Cooper

Biology Faculty Publications

In classical conditioning, an alteration in response occurs when two stimuli are regularly paired in close succession. An area of particular research interest is classical conditioning with a chemical signal and visual and/or tactile stimuli as the unconditional stimuli, to test manipulative and motor behaviors in a learning paradigm. A classical learning task chamber was developed to examine learning trends in a sighted surface-dwelling crayfish, Procambarus clarkii, and in a blind cave-dwelling crayfish, Orconectes australis packardi. We examined whether learning is influenced by environmental factors and/or reliance on different primary sensory modalities. Crayfish were trained to manipulate a large, cumbersome …

Bioavailability Of Manufactured Nanomaterials In Terrestrial Ecosystems, Jonathan D. Judy

Theses and Dissertations--Plant and Soil Sciences

Manufactured nanomaterials (MNMs) from the rapidly increasing number of consumer products that contain MNMs are being discharged into waste streams. Increasing evidence suggests that several classes of MNMs may accumulate in sludge derived from wastewater treatment and ultimately in soil following land application as biosolids. Little research has been conducted to evaluate the impact of MNMs on terrestrial ecosystems, despite the fact that land application of biosolids from wastewater treatment will be a major pathway for the introduction of MNMs to the environment. To begin addressing this knowledge gap, we have conducted a series of experiments designed to test how …

Evaluating The Sustainability Of Four Organic Vegetable Production Systems, Delia W. Scott

Theses and Dissertations--Plant and Soil Sciences

A field study evaluating the sustainability of four organic vegetable production systems was conducted in Lexington, Kentucky in 2006 and 2007. The four systems included no-till, raised beds covered with biodegradable black mulch, bare ground with shallow cultivation, and bare ground with shallow cultivation and wood chip mulch. The two-year study compared yield, weed control, labor, and costs associated with each system, as well as physical, chemical, and microbiological soil characteristics. In 2006, tomatoes (Lycopersicon esculentum Mill.) were grown in the four systems, with no significant difference in yield. Summer squash (Cucurbita pepo L.) was grown in the …

Oxidative Modification Of Lipoic Acid By Hne In Alzheimer Disease Brain, Sarita S. Hardas, Rukhsana Sultana, Amy M. Clark, Tina L. Beckett, Luke I. Szweda, M. Paul Murphy, D. Allan Butterfield

Chemistry Faculty Publications

Alzheimer disease (AD) is an age-related neurodegenerative disease characterized by the presence of three pathological hallmarks: synapse loss, extracellular senile plaques (SP) and intracellular neurofibrillary tangles (NFTs). The major component of SP is amyloid β-peptide (Aβ), which has been shown to induce oxidative stress. The AD brain shows increased levels of lipid peroxidation products, including 4-hydroxy-2-nonenal (HNE). HNE can react covalently with Cys, His, or Lys residues on proteins, altering structure and function of the latter. In the present study we measured the levels of the HNE-modified lipoic acid in brain of subjects with AD and age-matched controls. Lipoic acid …

Acoustic Emission Signal Of Lactococcus Lactis Before And After Inhibition With Nan3 And Infection With Bacteriophage C2, Debasish Ghosh, John M. Stencel, Clair D. Hicks, Frederick Payne, Didem Ozevin

Animal and Food Sciences Faculty Publications

The detection of acoustic emission (AE) from Lactococcus lactis, ssp lactis is reported in which emission intensities are used to follow and define metabolic activity during growth in nutrient broths. Optical density (OD) data were also acquired during L. lactis growth at 32°C and provided insight into the timing of the AE signals relative to the lag, logarithmic, and stationary growth phases of the bacteria. The inclusion of a metabolic inhibitor, NaN₃, into the nutrient broth eliminated bacteria metabolic activity according to the OD data, the absence of which was confirmed using AE data acquisition. The OD …

Economic Optimization And Precision Agriculture: A Carbon Footprint Story, Rachael M. Brown

Theses and Dissertations--Agricultural Economics

This thesis examines the economic and environmental impacts that precision agriculture technologies (PATs) can have on the carbon footprint of a grain farm. An analysis is offered using two manuscripts. The first examines the impacts of three PATs and compares the findings to a conventional farming method. It was found that all three PATs investigated showed a potential Pareto improvement over conventional farming. The second manuscript expanded the model used previously to in order to develop a process to construct a carbon efficient frontier (CEF). The model employed examined uniform and variable rate technologies. In addition to the CEF, a …

Modeling Of Co2-Water-Rock Interactions In A Mississippian Sandstone Reservoir Of Kentucky, Anne M. Schumacher

Theses and Dissertations--Earth and Environmental Sciences

This study examined CO₂-water-rock interactions occurring during a carbon sequestration pilot test into a Mississippian oil reservoir in western Kentucky. New samples (n=62) and archived data, both collected from oil wells, were used to characterize the chemistry of formation waters from the Sugar Creek field in Hopkins County. In addition, core and cuttings samples (n=17) from the reservoir and overlying cap-rocks in, or near, the field were analyzed for bulk and clay mineralogy using X-ray diffraction. Electric logs were used to select sample intervals within the overlying cap-rocks and the center of the producing zones in the Jackson …

Modeling Of An Air-Based Density Separator, Tathagata Ghosh

Theses and Dissertations--Mining Engineering

There is a lack of fundamental studies by means of state of the art numerical and scale modeling techniques scrutinizing the theoretical and technical aspect of air table separators as well as means to comprehend and improve the efficiency of the process. The dissertation details the development of a workable empirical model, a numerical model and a scale model to demonstrate the use of a laboratory air table unit.

The modern air-based density separator achieves effective density-based separation for particle sizes greater than 6 mm. Parametric studies with the laboratory scale unit using low rank coal have demonstrated the applicability …

Estimating The Economic Losses From Diseases And Extended Days Open With A Farm-Level Stochastic Model, Di Liang

Theses and Dissertations--Animal and Food Sciences

This thesis improved a farm-level stochastic model with Monte Carlo simulation to estimate the impact of health performance and market conditions on dairy farm economics. The main objective of this model was to estimate the costs of seven common clinical dairy diseases (mastitis, lameness, metritis, retained placenta, left displaced abomasum, ketosis, and milk fever) in the U.S. An online survey was conducted to estimate veterinary fees, treatment costs, and producer labor data. The total disease costs were higher in multiparous cows than in primiparous cows. Left displaced abomasum had the greatest costs in all parities ($404.74 in primiparous cows and …

The Modeling, Analysis And Control Of Resilient Manufacturing Enterprises, Yao Hu

Theses and Dissertations--Electrical and Computer Engineering

The resilience of manufacturing enterprises is an important research topic, since disruptions have severe effects on the normal operation of manufacturing enterprises, especially as manufacturing supply chains become global. Although many case studies have been carried out to address resilience in organizations, a systematic method to model and analyze the resilience dynamics in manufacturing enterprises is not well developed. This study is intended to conduct research on quantitative analysis and control for resilience.

After reviewing the literature addressing resilience, a modeling framework is presented to characterize the resilience of a manufacturing enterprise responding to disruptive events, which includes inventory ow …

Nanotechnology In The Food System: Consumer Acceptance And Willingness To Pay, Guzhen Zhou

Theses and Dissertations--Agricultural Economics

Nanotechnology is one of the key innovative technologies in the present century. The food industry has applied this technology in each of its sectors. Nanotechnology has tremendous potential in food and agriculture, including advancing agricultural cultivation and food production, enhancing food nutrition and flavor, and improving food packaging and preservation. However, the novel properties of nanoscale materials that allow beneficial applications are also accompanied with uncertainties, even unknown risks. A number of studies have examined public understanding as well as acceptance of nanotechnology via surveys in both the US and Europe. However, most of these studies concentrated on public attitudes …

Modeling Bedrock Mining Hotspots Within The Ouachita National Forest, Arkansas, Stephanie H. Mehlhope

Theses and Dissertations--Geography

This study, concentrating on the Ouachita Mountain Range in western-central Arkansas, extends prior work on treethrows and their influence on soil development in the region by supplying a method of determining hotspots of bedrock mining by treethrow. Binary logistic regression analysis was employed to determine the abiotic and biotic factors that are highly correlated with the rate of bedrock detachment found in uprooted rootwads from three study sites within the Ouachita National Forest. The produced logistic regression models suggest topographic factors, tree specific characteristics, as well as the local geology and soil characteristics all have a significant effect upon the …

Data Mining And Pattern Discovery Using Exploratory And Visualization Methods For Large Multidimensional Datasets, Hsin-Fang Li

Theses and Dissertations--Epidemiology and Biostatistics

Oral health problems have been a major public health concern profoundly affecting people’s general health and quality of life. Given that oral health data is composed of several measurable dimensions including clinical measurements, socio-behavioral factors, genetic predispositions, self-reported assessments, and quality of life measures, strategies for analyzing multidimensional data are neither computationally straightforward nor efficient. Researchers face major challenges to identify tools that circumvent the processes of manually probing the data.

The purpose of this dissertation is to provide applications of the proposed methodology on oral health-related data that go beyond identifying risk factors from a single dimension, and to …

Class I Waste-Disposal Wells And Class Ii Brine-Injection Wells In Kentucky, Thomas N. Sparks, David C. Harris, J. Richard Bowersox

Map and Chart--KGS

This map shows locations of disposal wells permitted and regulated by the U.S. Environmental Protection Agency under parts of their Underground Injection Control program. Only UIC Class I and Class II disposal wells are illustrated and described. EPA defines Class I as industrial and municipal waste-disposal wells and Class II as oil- and gas-related injection wells (EPA, 2012a). Disposal wells are designed to protect underground sources of drinking water. The primary function of this map is to provide general information about type, name, location, geology, and depth of injection zone for these disposal wells on a statewide basis.

Kentucky Geological Survey Procedures For Groundwater Tracing Using Fluorescent Dyes, James C. Currens

Information Circular--KGS

Karst terrain often develops from an ancestral landscape of surface-flowing streams, which leaves behind a relict pattern of the surface watershed divides. If caves only developed in ancestral watersheds, then groundwater tracing, for the purpose of groundwater basin mapping, would be unnecessary. But lithologic, structural, and hydrologic factors conspire to ensure that some caves extend headward faster than their neighbors and encroach upon adjacent groundwater basins to pirate drainage under the original surface divides. In many areas, groundwater basin boundaries have been significantly reorganized, to the point that there is little relationship to the ancestral surface watershed boundaries.

Joint Orientations In The Red River Gorge Geological Area, East-Central Kentucky, Steven L. Martin

Information Circular--KGS

The Red River Gorge Geological Area and Clifty Wilderness Area of Daniel Boone National Forest and Natural Bridge State Park in east-central Kentucky provide an excellent opportunity to observe and study differential weathering and erosion, mass wasting, and jointing in the development of cliffs, rock shelters, and natural arches. Joints in the study area have varying orientations, but dominant northeast- and northwest-striking orientations are prevalent. Jointing in the study area is related to unloading of overburden and regional tectonic stresses. Unloading joints result from removal of overburden from a rock mass, and orientations of joints are controlled by either residual …

Anterior Cruciate Ligament Prevention: Effect Of Neuromuscular Training Compliance On Muscular Strength Development, Daisuke Sugimoto

Theses and Dissertations--Rehabilitation Sciences

The anterior cruciate ligament (ACL) originates from posterior part of the medial side of the lateral condyle of femur to anterior intercondylar notch between a transverse meniscal ligament and medial side of medial meniscus of tibia. Once ACL is disrupted, pain, effusion and atrophy are commonly observable and cause functional disability. Because of the functional limitations, athletic participation is severely restricted. ACL injury is more prevalent in physically active females compared to their male counterparts in the sports of basketball and soccer in high school and collegiate levels.

Several attributes of females are considered risk factors for the higher ACL …

Essays On Fresh Vegetable Production And Marketing Practices, Michael Vassalos

Theses and Dissertations--Agricultural Economics

Commercial fresh vegetable production is one of the most rewarding and risky farming activities. The price and yield variations throughout the production year, the special characteristics of fresh vegetable produce (i.e. perishability), and the changing consumer demands are some of the factors contributing to the increased uncertainty faced by vegetable producers. This dissertation combined mathematical programming and econometric techniques to: 1) investigate the optimal production and marketing practices under different price distribution information scenarios, risk aversion levels and marketing outlets and 2) examine growers’ preferences as well the effect of risk aversion levels and growers’ risk perception on the choice …

A Robust Rgb-D Slam System For 3d Environment With Planar Surfaces, Po-Chang Su

Theses and Dissertations--Electrical and Computer Engineering

Simultaneous localization and mapping is the technique to construct a 3D map of unknown environment. With the increasing popularity of RGB-depth (RGB-D) sensors such as the Microsoft Kinect, there have been much research on capturing and reconstructing 3D environments using a movable RGB-D sensor. The key process behind these kinds of simultaneous location and mapping (SLAM) systems is the iterative closest point or ICP algorithm, which is an iterative algorithm that can estimate the rigid movement of the camera based on the captured 3D point clouds. While ICP is a well-studied algorithm, it is problematic when it is used in …

The Promise Of Parentheticals: An Empirical Study Of The Use Of Parentheticals In Federal Appellate Briefs, Michael D. Murray

Law Faculty Scholarly Articles

This article on current trends in briefing reports an empirical study of the use of parentheticals in federal appellate court briefs submitted between February 1, 2011, and July 31, 2011. The study was designed to answer this question: How are parentheticals currently used for rhetorical purposes in appellate briefs to explain a synthesis of authorities? My hypothesis entering the study was that parentheticals currently are used beyond a simple informational function in citation forms for four rhetorical purposes: (1) to quote and highlight portions of authorities ("quotation" function), (2) to explain and illustrate the principles induced from a synthesis of …

To Hava, And Beyond!, Joshua A. Douglas

Law Faculty Scholarly Articles

Book review of Martha Kropf and David C. Kimball, Helping America Vote: The Limits of Election Reform. New York, NY: Routledge, 2012, 154 pp., $41.95 (paperback).

Randomness, Uncertainty, And Economic Behavior: The Life Of Money In Eighteenth-Century Fiction, Devjani Roy

Theses and Dissertations--English

My dissertation argues that fiction produced in England during the frequent financial crises and political volatility experienced between 1770 and 1820 both reflected and shaped the cultural anxiety occasioned by a seemingly random and increasingly uncertain world. The project begins within the historical framework of the multiple financial crises that occurred in the late eighteenth century: seven crises took place between 1760 and 1797 alone, appearing seemingly out of nowhere and creating a climate of financial meltdown. But how did the awareness of economic turbulence filter into the creative consciousness? Through an interdisciplinary focus on cultural studies and behavioral economics, …

Two-Dimensional Hydrodynamic Modeling Of Two-Phase Flow For Understanding Geyser Phenomena In Urban Stormwater System, Zhiyu S. Shao

Theses and Dissertations--Civil Engineering

During intense rain events a stormwater system can fill rapidly and undergo a transition from open channel flow to pressurized flow. This transition can create large discrete pockets of trapped air in the system. These pockets are pressurized in the horizontal reaches of the system and then are released through vertical vents. In extreme cases, the transition and release of air pockets can create a geyser feature.

The current models are inadequate for simulating mixed flows with complicated air-water interactions, such as geysers. Additionally, the simulation of air escaping in the vertical dropshaft is greatly simplified, or completely ignored, in …

Moisture And Unit Weight Readings From A Complex Impedance Measuring Instrument, Kirk Andrew Jenkins

Theses and Dissertations--Civil Engineering

Complex Impedance Measuring Instruments (CIMI’s) are non-nuclear devices that calculate the dry unit weight and moisture content of soil by means of electromagnetic wave propagation theory. Unlike nuclear based test devices, these devices do not require certification or elaborate maintenance to own and operate. CIMI operation requires a soil specific calibration process where soil moisture and unit weight are correlated to electrical parameters. A new, smaller acrylic mold was developed as an alternative calibration tool to the manufacturer’s recommended mold. Calibrated soil models were generated using manufacturer recommended procedures as well as new procedures involving an acrylic mold. Models were …

Development Of A Multilayered Association Polymer System For Sequential Drug Delivery, Sharath Kumar Chinnakavanam Sundararaj

Theses and Dissertations--Biomedical Engineering

As all the physiological processes in our body are controlled by multiple biomolecules, comprehensive treatment of certain disease conditions may be more effectively achieved by administration of more than one type of drug. Thus, the primary objective of this research was to develop a multilayered, polymer-based system for sequential delivery of multiple drugs. This particular device was designed aimed at the treatment of periodontitis, a highly prevalent oral inflammatory disease that affects 90% of the world population. This condition is caused by bacterial biofilm on the teeth, resulting in a chronic inflammatory response that leads to loss of alveolar bone …

Kentrack 4.0: A Railway Trackbed Structural Design Program, Shushu Liu

Theses and Dissertations--Civil Engineering

The KENTRACK program is a finite element based railway trackbed structural design program that can be utilized to analyze trackbeds having various combinations of all-granular and asphalt-bound layered support. It is applicable for calculating compressive stresses at the top of subgrade, indicative of potential long-term trackbed settlement failure. Furthermore, for trackbeds containing asphalt layer, it is applicable for calculating tensile strains at the bottom of the asphalt layer, indicative of potential fatigue cracking. The program was recently expanded to include both English and international units. A procedure has been incorporated to provide a path to save results in a text …

Pressure Measurement At The Ballast-Tie Interface Of Railroad Track Using Matrix Based Tactile Surface Sensors, Michael T. Mchenry

Theses and Dissertations--Civil Engineering

The pressure distribution at the ballast-tie interface of railroad track plays a key role in overall track support. Failure of the ballast or tie can result from excessive loads that were not designed for, requiring increased maintenance and reducing railroad operating efficiency. Understanding the forces acting on the ballast and tie are required to design higher performance and longer lasting track. To further this understanding, the use of Matrix Based Tactile Surface Sensors (MBTSS) is employed to measure the actual pressure distribution at the ballast-tie interface, characterized by individual ballast particle contact points and non-uniform pressures. The research explores this …

Development Of A Constitutive Model Of Compacted Shales And Determination Of The Effect Of Weathering On Its Parameters, Isabel Cristina Gomez-Gutierrez

Theses and Dissertations--Civil Engineering

Compacted shales cause problems because they tend to degrade with time due to weathering. Degradation results in the shale deteriorating from a hard rock-like material to a soft fine-grained soil mass with lower shear strength and high deformability. Consequently, common problems that occur in embankments constructed with compacted shales include settlement and instabilities. Therefore, accelerating weathering prior to compaction by wetting and breaking down the shales before placement can reduce the deterioration during the service life of the construction. Extensive laboratory testing was performed in order to characterize the mechanical behavior of compacted shales.

Critical State theory is a clever …