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The Impact Of A Geriatric Trauma Unit On Patient Outcomes, Shannon E. Johnson Jan 2025

The Impact Of A Geriatric Trauma Unit On Patient Outcomes, Shannon E. Johnson

DNP Projects

Abstract

Background: Traumatic injuries in the geriatric (> 65) patient population can have devastating effects. Only a small percentage of these patients return to independent ambulation and living. As the population continues to age and life expectancy continues to increase, the incidence of traumatic injuries in geriatric patients will continue to increase. Geriatric friendly hospital wards in several disciplines have been shown to reduce length of stay and improve patient outcomes. However, there has been no research surrounding geriatric trauma wards specifically.

Purpose: The purpose of this quality improvement project was to evaluate the impact of admitting geriatric trauma patients …


Complete High Thoracic Spinal Cord Injury Causes Bowel Dysfunction In Mice, Olivia Wireman, Ellie L. Sams, Lynnet E. Richey, Gabrielle V. Hammers, Andrew N. Stewart, William M. Bailey, Samir P. Patel, John C. Gensel Jan 2025

Complete High Thoracic Spinal Cord Injury Causes Bowel Dysfunction In Mice, Olivia Wireman, Ellie L. Sams, Lynnet E. Richey, Gabrielle V. Hammers, Andrew N. Stewart, William M. Bailey, Samir P. Patel, John C. Gensel

Spinal Cord and Brain Injury Research Center Faculty Publications

Bowel dysfunction, is a prevalent and life-impacting comorbidity of spinal cord injury (SCI) with no long-term treatment available. SCI-induced colon changes including motility and fibrosis are understudied as are strategies to address SCI bowel dysfunction. This need remains partly due to the lack of a mouse model that recapitulates the human condition. We hypothesized that a high thoracic spinal transection in mice would trigger bowel dysfunction with coincident colon pathology similar to humans and rats after SCI. We observed bowel dysfunction as increased fecal pellet numbers within the colon, smaller pellet size, and decreased motility. Fecal pellets numbers in the …


Geographic Patterns Of Human Immunodeficiency Virus (Hiv) Risk Behaviors Among Older Adults: A Strategy For Identifying Space As A Risk Exposure, Laneshia R. Conner, Reuben Adatorwovor, Sarah Jane Robbins, Rujeko O. Machinga-Asaolu, Kathryn Showalter, Carrie B. Oser Jan 2025

Geographic Patterns Of Human Immunodeficiency Virus (Hiv) Risk Behaviors Among Older Adults: A Strategy For Identifying Space As A Risk Exposure, Laneshia R. Conner, Reuben Adatorwovor, Sarah Jane Robbins, Rujeko O. Machinga-Asaolu, Kathryn Showalter, Carrie B. Oser

Social Work Faculty Publications

Objectives: This study examined geographical patterns of HIV risk among adults aged 60 and older.

Methods: The 2019 Behavioral Risk Factor Surveillance System (BRFSS) weighted data was used to analyze self-reported participation in HIV risk behaviors among older adults (n = 62,852). Logistic regression models were used on a dichotomous HIV risk variable to map the distribution of HIV risk behaviors across both census regions and divisions.

Results: The weighted model revealed significance across regions. Across all regions, identifying as female, identifying as Hispanic, and reporting not having depression were protective from participating in HIV risk behaviors.

Discussion: The …


Third Party Negotiated Hospital Pricing In Rural And Urban Hospitals Within 12 U.S. States, Lindsey R. Hammerslag, Aaron P. Smith, Jeffrey C. Talbert Jan 2025

Third Party Negotiated Hospital Pricing In Rural And Urban Hospitals Within 12 U.S. States, Lindsey R. Hammerslag, Aaron P. Smith, Jeffrey C. Talbert

Rural & Underserved Health Research Center Publications

No abstract provided.


Longitudinal Relationship Between Problematic Social Networking Use And Internalizing Problems, Lindsay Roesel Jan 2025

Longitudinal Relationship Between Problematic Social Networking Use And Internalizing Problems, Lindsay Roesel

Theses and Dissertations--Family Sciences

The purpose of this study is to examine the longitudinal and bidirectional relationships between problematic social networking use (PSNU) and internalizing problems (depressive symptoms and self-esteem) in adolescents. Data were collected from N = 360 adolescents from two public high schools in Turkey, 14.58 years old in 9th grade at Time 1 (54.3% females). Participants completed four assessments regarding problematic social media use, depression and self-esteem, over the course of two school years, once per semester in 9th and 10th grades. The study tested a series of hypotheses which tested the bidirectional relationships between PSNU on depressive …


Trace Level Identifications Of N-Ethylnicotinamide In Racing Horses Associated With A Vitamin B3 Supplement: Case Reports And Analysis, Clara Fenger, Kimberly Brewer, Abelardo Morales-Briceño, Andreas F. Lehner, George A. Maylin, Robert Holland, Levent Dirikolu, Thomas Tobin Jan 2025

Trace Level Identifications Of N-Ethylnicotinamide In Racing Horses Associated With A Vitamin B3 Supplement: Case Reports And Analysis, Clara Fenger, Kimberly Brewer, Abelardo Morales-Briceño, Andreas F. Lehner, George A. Maylin, Robert Holland, Levent Dirikolu, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Nikethamide, N,N-diethyl-3-pyridinecarboxamide (Coramine®) is a central nervous system stimulant at one time used therapeutically in human medicine but no longer marketed in the US. Nikethamide is classified a Drug Class 1, Penalty Class A substance by the Association of Racing Commissioners International (ARCI) and as a Horseracing Integrity and Safety Authority (HISA) SO or banned Stimulant that lacks FDA approval. Identifications of Nikethamide or its metabolite N-Ethylnicotinamide in racing samples can result in significant penalties in horse racing. Nikethamide is rapidly metabolized to N-Ethylnicotinamide, which remains detectable in plasma and urine leading to its use as a regulatory “marker” of …


Linkage To Treatment And Recovery Support Services For Patients With A Substance Use Disorder, Seif Atyia, Terry Bunn, Dana Quesinberry, Timothy Prince Jan 2025

Linkage To Treatment And Recovery Support Services For Patients With A Substance Use Disorder, Seif Atyia, Terry Bunn, Dana Quesinberry, Timothy Prince

Epidemiology and Environmental Health Faculty Publications

Objective The purpose of this study was to survey current physicians in Kentucky to evaluate their management of patients with substance use disorder (SUD), with a focus on the identification of their referral methods for linkage to SUD treatment and recovery support services. Methods A cross-sectional study was performed through a developed survey that was administered by e-mail to all 12,152 in-state physicians licensed in Kentucky; 524 responded. Addiction specialists, emergency physicians, and psychiatrists were categorized separately; family medicine and internal medicine (FM/IM) physicians were combined into one category; all of the other specialties were grouped into an "Other"category. The …


Serious Bacterial Infections And Hepatitis C Virus Among People Who Inject Drugs, Thomas J. Stopka, Robin M. Nance, L. Sarah Mixson, Hunter Spencer, Judith I. Tsui, Judith M. Leahy, Mai T. Pho, Jean Dejace, Judith Feinberg, April M. Young, Wei Teng Yang, Amelia Baltes, Eric Romo, Randall T. Brown, Kerry Nolte, William C. Miller, William A. Zule, Wiley D. Jenkins, Joseph A. Delaney, Peter D. Friedmann Jan 2025

Serious Bacterial Infections And Hepatitis C Virus Among People Who Inject Drugs, Thomas J. Stopka, Robin M. Nance, L. Sarah Mixson, Hunter Spencer, Judith I. Tsui, Judith M. Leahy, Mai T. Pho, Jean Dejace, Judith Feinberg, April M. Young, Wei Teng Yang, Amelia Baltes, Eric Romo, Randall T. Brown, Kerry Nolte, William C. Miller, William A. Zule, Wiley D. Jenkins, Joseph A. Delaney, Peter D. Friedmann

Epidemiology and Environmental Health Faculty Publications

Limited research has examined the possible synergistic interrelationships between serious bacterial infections (SBIs) of the heart (i.e., endocarditis), bone, spine, brain, or joints (e.g., osteomylelitis) and hepatitis C virus (HCV) infections. We examined whether syndemic interactions existed between SBI, HCV, and substance-use-related factors in rural communities, hypothesizing that injection-mediated risks elevated the likelihood for both SBIs and HCV infections, which could be exacerbated by synergistic biological–biological or biological and social interactions. We calculated the prevalence ratios (PRs) of past-year SBI associated with each risk factor in separate models. Effect modification among significant risk factors was assessed using multiplicative interaction. Among …


Viral Transcript And Tumor Immune Microenvironment-Based Transcriptomic Profiling Of Hpv-Associated Head And Neck Squamous Cell Carcinoma Identifies Subtypes Associated With Prognosis, Anastasiia Nikitina, Daria Kiriy, Andrey Tyshevich, Dmitry Tychinin, Zoya Antysheva, Anastasya Sobol, Vladimir Kushnarev, Nara Shin, Jessica H. Brown, James Lewis, Krystle A. Lang Kuhs, Robert Ferris, Lori Wirth, Nikita Kotlov, Daniel L. Faden Jan 2025

Viral Transcript And Tumor Immune Microenvironment-Based Transcriptomic Profiling Of Hpv-Associated Head And Neck Squamous Cell Carcinoma Identifies Subtypes Associated With Prognosis, Anastasiia Nikitina, Daria Kiriy, Andrey Tyshevich, Dmitry Tychinin, Zoya Antysheva, Anastasya Sobol, Vladimir Kushnarev, Nara Shin, Jessica H. Brown, James Lewis, Krystle A. Lang Kuhs, Robert Ferris, Lori Wirth, Nikita Kotlov, Daniel L. Faden

Epidemiology and Environmental Health Faculty Publications

Human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HPV-positive HNSCC) has distinct biological characteristics from HPV-negative HNSCC. Using an AI-based analytical platform on meta cohorts, we profiled expression patterns of viral transcripts and HPV viral genome integration, and classified the tumor microenvironment (TME). Unsupervised clustering analysis revealed five distinct and novel TME subtypes across patients (immune-enriched, highly immune and B-cell enriched, fibrotic, immune-desert, and immune-enriched luminal). These TME subtypes were highly correlated with patient prognosis. In order to understand specific factors associated with prognosis, we used the unsupervised clustering of an HPV-positive HNSCC cohort from The Cancer Genome Atlas …


Fairehr, Karen S. Galea, Finlay Brooker, Shahzad Rashid, Michael Bader, Yu Ait Bamai, Jos Bessems, Embialle Mengistie Beyene, Alison Connolly, Carla Costa, Pravina Deligannu, Radu Corneliu Duca, Kaoutar Chbihi, Kasahun Eba, Manosij Ghosh, Melissa Gonzales, Stuart Harrad, Erin N. Haynes, Nancy B. Hopf, Po Chin Huang, Kate Jones, Konstantinos M. Kasiotis, Ming Kei Chung, Jihyon Kil, Holger Koch, Jung Hwan Kwon, Elizabeth Ziying Lin, Henriqueta Louro, Kyriaki Machera Jan 2025

Fairehr, Karen S. Galea, Finlay Brooker, Shahzad Rashid, Michael Bader, Yu Ait Bamai, Jos Bessems, Embialle Mengistie Beyene, Alison Connolly, Carla Costa, Pravina Deligannu, Radu Corneliu Duca, Kaoutar Chbihi, Kasahun Eba, Manosij Ghosh, Melissa Gonzales, Stuart Harrad, Erin N. Haynes, Nancy B. Hopf, Po Chin Huang, Kate Jones, Konstantinos M. Kasiotis, Ming Kei Chung, Jihyon Kil, Holger Koch, Jung Hwan Kwon, Elizabeth Ziying Lin, Henriqueta Louro, Kyriaki Machera

Epidemiology and Environmental Health Faculty Publications

The FAIREHR (Findable, Accessible, Interoperable, Reusable Environmental and Health Registry) platform is a state-of-the-art online registry for prospective harmonization of human biomonitoring (HBM). It was developed by the HBM working group of the Europe Regional Chapter of the International Society of Exposure Science (ISES Europe) and is supported by the HBM Global Network. FAIREHR is designed to harmonize HBM metadata and support the implementation of the FAIR (Findable, Accessible, Interoperable and Reusable) Guiding Principles throughout HBM studies or programs. The registry enables preregistration of HBM by capturing key metadata on study design, metadata management, and planned methods before participant recruitment. …


Implementing And Documenting Cultural Adaption Of Evidence-Based Practice Strategies To Reduce Opioid Overdose Deaths, Erin B Gibson, Lashawn Glasgow, Monica Nouvong, Margaret Mcgladrey, Darcy Freedman, Deborah Chassler, Rachel Vickers-Smith, Madeline D'Onfro, Dawn A Goddard-Eckrich, Timothy Hunt, Avik Chatterjee, Janae Holloway, Katie Fain, Rachel Sword Cruz, Linda Sprague Martinez Jan 2025

Implementing And Documenting Cultural Adaption Of Evidence-Based Practice Strategies To Reduce Opioid Overdose Deaths, Erin B Gibson, Lashawn Glasgow, Monica Nouvong, Margaret Mcgladrey, Darcy Freedman, Deborah Chassler, Rachel Vickers-Smith, Madeline D'Onfro, Dawn A Goddard-Eckrich, Timothy Hunt, Avik Chatterjee, Janae Holloway, Katie Fain, Rachel Sword Cruz, Linda Sprague Martinez

Epidemiology and Environmental Health Faculty Publications

INTRODUCTION: Addressing the opioid overdose crisis requires developing contextually specific strategies promoting the adoption of evidence-based practices (EBPs) to prevent and treat opioid use disorder (OUD), including overdose education and naloxone distribution (OEND) and medications for OUD (MOUD). To effectively reach the groups most affected by the opioid crisis, EBP strategies must be adjusted to fit the culture and contexts of different communities.

METHODS: The HEALing Communities Study engaged coalitions in 67 communities across four states to select and implement EBP strategies to reduce opioid overdose mortality. Coalitions were encouraged to culturally adapt EBP strategies for "special populations," which were …


Precision Public Health Alliances As A Model And Method For Community Engagement, Margaret L. Mcgladrey, Mary Elizabeth Lacy, Kristen Mcquerry, Rachel Hogg-Graham, Svetla Slavova, Emily R. Clear, Kory Heier, Caitline Phan, Megan Hall, Ryan Parker, Mindy Keeton, Jennifer Sword, Thomas Ard, Charbel Salem Jan 2025

Precision Public Health Alliances As A Model And Method For Community Engagement, Margaret L. Mcgladrey, Mary Elizabeth Lacy, Kristen Mcquerry, Rachel Hogg-Graham, Svetla Slavova, Emily R. Clear, Kory Heier, Caitline Phan, Megan Hall, Ryan Parker, Mindy Keeton, Jennifer Sword, Thomas Ard, Charbel Salem

Epidemiology and Environmental Health Faculty Publications

Using precision analytics approaches with population health data helps identify localized patterns of social determinants and comorbidities, supporting the design of tailored interventions. The University of Kentucky College of Public Health (UKCPH) and UK King’s Daughters (UKKD) have partnered to create a Precision Public Health Alliance (PPHA) applying precision analytics to UKKD electronic health records (EHR) as well as secondary datasets to map social, demographic, and clinical comorbidity factors onto colorectal cancer (CRC) screening data in UKKD’s rural service area (the northeastern Kentucky counties of Boyd, Carter, Greenup, and Lawrence and southeast Ohio county of Lawrence). In addition to UKKD …


Defining An Irrelevant Plasma Concentration For Trichlormethiazide In Racing Horses – A Case Report And Analysis, Kimberly Brewer, Justin C. Holmes, Clara Fenger, Abelardo Morales-Briceño, Andreas F. Lehner, George A. Maylin, Robert Holland, Levent Dirikolu, Thomas Tobin Jan 2025

Defining An Irrelevant Plasma Concentration For Trichlormethiazide In Racing Horses – A Case Report And Analysis, Kimberly Brewer, Justin C. Holmes, Clara Fenger, Abelardo Morales-Briceño, Andreas F. Lehner, George A. Maylin, Robert Holland, Levent Dirikolu, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

This communication reviews the matter of the clinical, pharmacological, and regulatory significance of a 4.95 nanogram/ml identification of trichlormethiazide in urine from a horse six days after administration of a compounded trichlormethiazide/ dexamethasone preparation. This combination of dexamethasone and trichlormethiazide has historically been widely used in bovine and equine medicine to reduce local inflammation and edema. The horse was administered an oral formulation of trichlormethiazide 400 mg /dexamethasone 10 mg per packet under veterinary supervision on days 7 and 6 before the race in question. Following the race, the post-race urine sample from the horse tested “positive” for trichlormethiazide at …


Trace Level Identifications Of N-Ethylnicotinamide In Racing Horses Associated With A Vitamin B3 Supplement: Case Reports And Analysis, Clara Fenger, Kimberly Brewer, Abelardo Morales-Briceño, Andreas F. Lehner, George A. Maylin, Robert Holland, Levent Dirikolu, Thomas Tobin Jan 2025

Trace Level Identifications Of N-Ethylnicotinamide In Racing Horses Associated With A Vitamin B3 Supplement: Case Reports And Analysis, Clara Fenger, Kimberly Brewer, Abelardo Morales-Briceño, Andreas F. Lehner, George A. Maylin, Robert Holland, Levent Dirikolu, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Nikethamide, N,N-diethyl-3-pyridinecarboxamide (Coramine®) is a central nervous system stimulant at one time used therapeutically in human medicine but no longer marketed in the US. Nikethamide is classified a Drug Class 1, Penalty Class A substance by the Association of Racing Commissioners International (ARCI) and as a Horseracing Integrity and Safety Authority (HISA) SO or banned Stimulant that lacks FDA approval. Identifications of Nikethamide or its metabolite N-Ethylnicotinamide in racing samples can result in significant penalties in horse racing. Nikethamide is rapidly metabolized to N-Ethylnicotinamide, which remains detectable in plasma and urine leading to its use as a regulatory “marker” of …


Anabolic Properties Of The Progestin Altrenogest And Its Regulation As An Environmental Substance In Horse Racing – Review And Analysis, Andreas F. Lehner, Levent Dirikolu, Sarah Jacob, Kimberly Brewer, Abelardo Morales Briceñoe, Robert Holland, George Maylin, Clara Fenger, Thomas Tobin Jan 2025

Anabolic Properties Of The Progestin Altrenogest And Its Regulation As An Environmental Substance In Horse Racing – Review And Analysis, Andreas F. Lehner, Levent Dirikolu, Sarah Jacob, Kimberly Brewer, Abelardo Morales Briceñoe, Robert Holland, George Maylin, Clara Fenger, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Altrenogest is a progestogen substance used in equine medicine for the synchronization of ovulation during the spring breeding season and the control of estrus in mares. It accomplishes its actions by down-regulation of endometrial progesterone receptors and repression of estrogen receptor transcriptional activation. However, various groups have also measured androgen receptor binding activity for altrenogest in vitro; these findings combined with androgenic and anabolic properties roughly 1/20 in potency of testosterone and its structural similarity to the anabolic steroid trenbolone have created concerns among racing authorities of altrenogest’s potential abilities to alter the outcome of equine athletic performance, even though …


Development Of An Artificial Intelligence Powered Software For Automated Analysis Of Skeletal Muscle Ultrasonography, Zoe Calulo Rivera, Felipe González-Seguel, Arimitsu Horikawa-Strakovsky, Catherine Granger, Aarti Sarwal, Sanjay Dhar, George Ntoumenopoulos, Jin Chen, V. K. Cody Bumgardner, Selina M. Parry, Kirby P. Mayer, Yuan Wen Jan 2025

Development Of An Artificial Intelligence Powered Software For Automated Analysis Of Skeletal Muscle Ultrasonography, Zoe Calulo Rivera, Felipe González-Seguel, Arimitsu Horikawa-Strakovsky, Catherine Granger, Aarti Sarwal, Sanjay Dhar, George Ntoumenopoulos, Jin Chen, V. K. Cody Bumgardner, Selina M. Parry, Kirby P. Mayer, Yuan Wen

Center for Muscle Biology Faculty Publications

Muscle ultrasound has high utility in clinical practice and research; however, the main challenges are the training and time required for manual analysis to achieve objective quantification of muscle size and quality. We aimed to develop and validate a software tool powered by artificial intelligence (AI) by measuring its consistency and comparability of expert manual analysis quantifying lower limb muscle ultrasound images. Quadriceps complex (QC) and tibialis anterior (TA) muscle images of healthy, intensive care unit, and/or lung cancer participants were captured with portable devices. Manual analyses of muscle size and quality were performed by experienced physiotherapists taking approximately 24 …


The Effect Of Fructose Metabolism On Hepatic De Novo Lipogenesis And Adipose Tissue Insulin Resistance, Taghreed Ibrahim Fadhul Jan 2025

The Effect Of Fructose Metabolism On Hepatic De Novo Lipogenesis And Adipose Tissue Insulin Resistance, Taghreed Ibrahim Fadhul

Theses and Dissertations--Nutritional Sciences

There is a worldwide epidemic of obesity and metabolic dysfunction. The root cause of obesity is driven by a positive energy balance, which is a consequence of increased caloric intake and decreased energy expenditure. Energy intake is the more dominant force, as increasing energy expenditure is a time-consuming and labor-intensive process. The caloric surplus can be mainly accounted for by increased consumption of high-fat and high-sugar diets. While the risks associated with fat consumption are well-documented, the impact of sugar intake is less understood.

Fructose is a simple sugar widely consumed in modern diets. Its intake has been associated with …


Spermidine And Polyamine Blockade As Key Mediators Of Intestinal Epithelial Cell Functions, Madison Lynn Flory Jan 2025

Spermidine And Polyamine Blockade As Key Mediators Of Intestinal Epithelial Cell Functions, Madison Lynn Flory

Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics

Frequently, alterations in the composition of the gut microbiota and its metabolites are linked with intestinal diseases, including inflammatory bowel disease and colorectal cancer. However, the direct connections between alterations in the microbiome and disease states often remain elusive. Prior research has identified increases in both polyamines, which are a class of microbial metabolite, and in the abundance of bacteria that can produce polyamines, in a murine colorectal cancer model. Understanding the significance of the interaction between these microbial metabolites and intestinal epithelial cells (IECs) will provide new and expanded evidence of the importance of the gut microbiome in colorectal …


West Virginia V. Epa: Considerations For The Future Of Epa Greenhouse Gas Regulation, Shavonnie R. Carthens Jan 2025

West Virginia V. Epa: Considerations For The Future Of Epa Greenhouse Gas Regulation, Shavonnie R. Carthens

Law Faculty Scholarly Articles

When compared to historical levels, the air quality in the United States has improved. However, exposure to air pollution still rises to the top of environmental health risks experienced by Americans. It is estimated that one hundred thousand to two hundred thousand deaths annually are associated with this exposure, which exceeds the deaths from murders and car crashes combined. Further, evidence establishes that “rising concentrations of carbon dioxide, methane, and other greenhouse gases pose serious threats to public health.” Looking to the sources of greenhouse gas emissions, fossil fuel-fired power plants are the largest source of greenhouse gas emissions in …


Open Access And Citation Impact: Modality, Funding, Publisher, And Disciplinary Trends At The University Of Kentucky, Ben Rawlins, Mitchell Scott Jan 2025

Open Access And Citation Impact: Modality, Funding, Publisher, And Disciplinary Trends At The University Of Kentucky, Ben Rawlins, Mitchell Scott

Library Faculty and Staff Publications

As publishers and libraries attempt to align business models and collection strategies to an ever-increasing open access (OA) publishing landscape, both have found that the message of open access citation advantage (OACA) resonates with current and prospective authors. Despite its widespread promotion and acceptance, however, OACA is not universal and is subject to ongoing debate. This quantitative study contributes to the OACA debate and research with a longitudinal focus on citation data from journal articles published 2018-2021 by University of Kentucky affiliated authors. The article and citation data for University of Kentucky affiliated authors are supplemented with University of Kentucky …


West Virginia V. Epa: Consideration For The Future Of Epa Greenhouse Gas Regulation, Shavonnie R. Carthens Jan 2025

West Virginia V. Epa: Consideration For The Future Of Epa Greenhouse Gas Regulation, Shavonnie R. Carthens

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

In this article, Shavonnie Carthens examines the implications of West Virginia v. EPA, emphasizing how the Supreme Court’s use of the major questions doctrine creates uncertainty around the Environmental Protection Agency’s (“EPA”) authority to regulate greenhouse gas emissions. It argues that, in light of the doctrine’s growing influence and the end of Chevron deference, Congress should revise the Clean Air Act to explicitly authorize the EPA to regulate greenhouse emissions through system-based transitions to cleaner power-generating sources, public health-conscious considerations, and multi-agency regulatory approaches to ensure durable and effective climate policy.


Quieting The Cacophony: How To Reduce Greenwashing And Environmental Damage From The Food Industry, Alex Woodward Jan 2025

Quieting The Cacophony: How To Reduce Greenwashing And Environmental Damage From The Food Industry, Alex Woodward

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

In this article, Alex G. Woodward addresses the problem of greenwashing and environmental harm caused by industrial agriculture and misleading food labeling. Woodward explains that while agriculture is essential to feeding a growing global population, its large-scale, profit-driven practices cause significant environmental damage. Woodward argues for a strategy that compels transparency through warning labels and expanding credible certification frameworks. Woodward proposes that the USDA implement a tiered labeling system under its Organic Program and require factual, noncontroversial disclosures about environmental harms on food packaging, with the goal of informing consumers, restoring trust, and incentivizing environmentally responsible agricultural practices.


The Impact Of Veterinary Stewardship Program Implementations On Backyard Chicken Farming In Rural Georgia, Lauren Ashley Herrin Jan 2025

The Impact Of Veterinary Stewardship Program Implementations On Backyard Chicken Farming In Rural Georgia, Lauren Ashley Herrin

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

In this article, Lauren Ashley Herrin examines the impacts of new FDA veterinary stewardship regulations on backyard chicken farming in rural Georgia. She explains that requiring prescriptions for previously over-the-counter antibiotics disproportionately harms low-income and rural communities by limiting access to affordable veterinary care, worsening risks of disease spread and public health threats. Herrin argues for policy approaches that balance antimicrobial resistance concerns with the realities of rural accessibility. She proposes solutions such as telehealth veterinary consultations, scholarship programs to encourage rural veterinary practice, and expanding prescriptive authority for veterinary technicians to ensure sustainable animal health care in underserved areas


When Breathing Becomes Wheezing: Why Kentucky Should Require Schools To Conduct Radon Testing, Abbey Norvell Jan 2025

When Breathing Becomes Wheezing: Why Kentucky Should Require Schools To Conduct Radon Testing, Abbey Norvell

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

In this note, Abbey Norvell analyzes the dangers of radon exposure in Kentucky schools, highlighting the state’s nation-leading lung cancer rates and the heightened risks for children. She explains that Kentucky has no law requiring schools to test for or mitigate radon levels, leaving students vulnerable. Norvell argues for mandatory radon testing and remediation in Kentucky schools. She proposes legislation modeled on other states requiring testing in both public and private schools within five years, and remediation within two years if levels exceed EPA standards.


Pesticide Lies! A Call For Epa Action As Recent Judicial Decisions Reveal The Harmful Truth Resulting From Exposure, Stevi Whitman Jan 2025

Pesticide Lies! A Call For Epa Action As Recent Judicial Decisions Reveal The Harmful Truth Resulting From Exposure, Stevi Whitman

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

In this note, Stevi Whitman analyzes the dangers of weak pesticide regulation in the United States. Whitman explains that the EPA’s reliance on the vague “unreasonable adverse effects” standard under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) allows harmful products like Roundup to remain on the market despite strong evidence of health risks. Whitman argues for strengthening U.S. pesticide laws to match the European Union’s stricter safety threshold. She proposes amending FIFRA to require proactive bans on hazardous pesticides and greater accountability from manufacturers to better protect public health and the environment.


Chronic Sleep Fragmentation Differentially Affects Alzheimer’S Disease Pathology In Male And Female AppSaa Knock-In Mice, Margaret R. Hawkins, Haleigh R. Whitlock, Carrie E. Johnson, Teresa Macheda, Ma Kayla F. Cox, Madison G. Lapid, Kelly N. Roberts, Heather M. Hash, Esther G. Drinkard, Sridhar Sunderam, Bruce F. O’Hara, Michael P. Murphy, Marilyn J. Duncan, Adam D. Bachstetter Jan 2025

Chronic Sleep Fragmentation Differentially Affects Alzheimer’S Disease Pathology In Male And Female AppSaa Knock-In Mice, Margaret R. Hawkins, Haleigh R. Whitlock, Carrie E. Johnson, Teresa Macheda, Ma Kayla F. Cox, Madison G. Lapid, Kelly N. Roberts, Heather M. Hash, Esther G. Drinkard, Sridhar Sunderam, Bruce F. O’Hara, Michael P. Murphy, Marilyn J. Duncan, Adam D. Bachstetter

Biology Faculty Publications

Introduction: Sleep fragmentation often precedes Alzheimer’s disease (AD) diagnosis and represents a potential modifiable risk factor, especially among women who have higher prevalence of both sleep disorders and AD. Methods: This study investigated how chronic sleep fragmentation affects neuroinflammation and amyloid-beta (Aβ) accumulation in male and female APPSAA knock-in mice, a physiologically relevant AD model expressing APP at normal levels. APPSAA mice of both sexes (N=8/sex/strain, 8 months old) underwent either 5 weeks of chronic sleep fragmentation administered during the light phase using an automated sweeper system or undisturbed sleep. Sleep-wake patterns and circadian rhythms were monitored using …


“I Just Don’T Find It Interesting”, Jennifer L. Osterhage, Utku Caybas, Jaeyun Han, Ellen L. Usher Jan 2025

“I Just Don’T Find It Interesting”, Jennifer L. Osterhage, Utku Caybas, Jaeyun Han, Ellen L. Usher

Biology Faculty Publications

Situated expectancy-value theory (SEVT) posits that students’ expectancies for success, task values, and perceived costs affect their performance in STEM courses. Less is known about how students’ majors and timing of course completion affect motivational processes. Using the SEVT framework, this study utilised a convergent mixed methods approach to investigate academic motivation among students (N = 646) who enrolled in introductory biology at a large public university. Survey data revealed that students majoring in Biology were more motivated than students from other majors, although academic major was not directly associated with final grade. Upper-level students reported significantly lower competence-related beliefs …


Effect Of The Communities That Heal Intervention On Overdose Education And Naloxone Distribution, Patricia R. Freeman, Alexander Y. Walley, T. John Winhusen, Emmanuel A. Oga, Jennifer Villani, Timothy Hunt, Redonna K. Chandler, Douglas R. Oyler, Brittni Reilly, Kitty Gelberg, Christian Douglas, Michael S. Lyons, Ja Nae Holloway, Nathan A. Vandergrift, Joella W. Adams, Katherine Asman, Trevor J. Baker, Candace J. Brancato, Debbie M. Cheng, Janet E. Childerhose, James L. David, Daniel J. Feaster, Louisa Gilbert, La Shawn M. Glasgow, Dawn A. Goddard-Eckrich, Charles Knott, Hannah K. Knudsen, Michelle R. Lofwall Jan 2025

Effect Of The Communities That Heal Intervention On Overdose Education And Naloxone Distribution, Patricia R. Freeman, Alexander Y. Walley, T. John Winhusen, Emmanuel A. Oga, Jennifer Villani, Timothy Hunt, Redonna K. Chandler, Douglas R. Oyler, Brittni Reilly, Kitty Gelberg, Christian Douglas, Michael S. Lyons, Ja Nae Holloway, Nathan A. Vandergrift, Joella W. Adams, Katherine Asman, Trevor J. Baker, Candace J. Brancato, Debbie M. Cheng, Janet E. Childerhose, James L. David, Daniel J. Feaster, Louisa Gilbert, La Shawn M. Glasgow, Dawn A. Goddard-Eckrich, Charles Knott, Hannah K. Knudsen, Michelle R. Lofwall

Sociology Faculty Publications

Objectives. To determine whether the Communities That HEAL (CTH) intervention is effective in increasing naloxone distribution compared with usual care. Methods. The HEALing (Helping to End Addiction Long-Term) Communities Study (HCS) is a clusterrandomized, parallel-arm, wait-list controlled implementation science trial testing the impact of the CTH intervention on increasing the use of evidence-based practices to lower opioid-related overdose deaths. Communities (n567) highly impacted by opioid overdose in Kentucky, Massachusetts, New York, and Ohio were allocated to CTH intervention (n534) or wait-list comparison (usual care; n533) arms. The primary outcome for this study was the number of naloxone units distributed in …


Cause Or Consequence? Evaluating The Evidence For Housing Instability As A Predictor Of Adult Well-Being, Hope Harvey, Brielle Bryan Jan 2025

Cause Or Consequence? Evaluating The Evidence For Housing Instability As A Predictor Of Adult Well-Being, Hope Harvey, Brielle Bryan

Sociology Faculty Publications

No abstract provided.


Structural Ableism, Health, And Functioning Among People With Disabilities, Robyn Lewis Brown Jan 2025

Structural Ableism, Health, And Functioning Among People With Disabilities, Robyn Lewis Brown

Sociology Faculty Publications

This study examined how structural ableism, conceptualized through the social determinants of health framework, impacts health outcomes among people with disabilities. Using multilevel regression analysis with data from the 2020 National Survey on Health and Disability (N = 2,175) paired with state-level indicators from the 2019 American Community Survey, it investigated associations between state-level disparities (in educational attainment, income, health insurance coverage, housing accessibility, and public transportation access) and self-rated health and functional limitation. Results demonstrated that structural ableism operates through distinct pathways for each health outcome. Income, health insurance, and transportation gaps by disability status at the state level …