Digital Commons Network^™

Professional Quality Of Life Of Air Force First Sergeants: An Exploratory Study, Ryan K. Barney

Theses and Dissertations--Social Work

This exploratory study was designed to measure the prevalence and correlates of professional quality of life constructs in a novel population: active-duty Air Force First Sergeants. Given the similarities in duties and stressors that First Sergeants encounter with those of other helping professionals, this study aimed to expand the scope of existing professional quality of life research by applying Stamm’s (2010) professional quality of life framework to cross-sectional survey research with a sample of First Sergeants. Four primary research questions guided this study: first, what is the prevalence of secondary traumatic stress (STS), burnout, and compassion satisfaction in a sample …

An Exploration Of Desired Abstinent And Non- Abstinent Recovery Outcomes Among People Who Use Methamphetamine, Alex Elswick, Amanda Fallin-Bennett, Karen L. Roper, Evan Batty, Christopher J. Mclouth, William W. Stoops, Hilary L. Surratt, Carrie B. Oser

UK CARES Faculty Publications

Background In the United States, complete abstinence persists as the standard for demonstrating recovery success from substance use disorders (SUDs), apart from alcohol use disorder (AUD). Although the FDA has recently indicated openness for non-abstinence outcomes as treatment targets, the traditional benchmark of complete abstinence for new medications to treat SUDs remains a hurdle and overshadows other non-abstinent outcomes desired by people with SUDs (e.g., improved sleep, employment, family reunification). This study sought to expand the definition of recovery to include non-abstinent pathways by exploring non-abstinence-based outcomes desired by people who use methamphetamine (PWUM).

Methods Participants (n = 100) were …

Covid-19 Risk And Crisis Communication Challenges And Opportunities: Qualitative Insights From Rural Wastewater Surveillance Partners, Savannah Tucker, Beverly May, Matthew Liversedge, Scott M. Berry, James W. Keck, Anna G. Hoover

UK CARES Faculty Publications

Objectives: Understand perceptions of COVID-19 messages and information sources among rural wastewater treatment plant operators to inform context-specific communication strategies for implementing wastewater surveillance methodologies locally.

Methods: Eight employees from 7 Eastern Kentucky facilities involved in SARS-CoV-2 wastewater surveillance participated in semi-structured interviews. Respondents shared perceptions of traditional and social media COVID-19 information channels in their communities, as well as factors influencing trustworthiness of sources. Using the U.S. Centers for Disease Control and Prevention’s Crisis and Emergency Risk Communication (CERC) framework, 3 investigators conducted iterative, thematic coding of interview transcripts.

Results: Respondents’ statements most frequently related to “Be Credible,” “Be …

Floral Encounters: Examining The Role Of Experience Goods And Promoters In Specialty Cut Flower Workshops, Savannah L. Columbia

Theses and Dissertations--Agricultural Economics

This thesis provides insight for any farmer interested in agritourism, specifically, specialty cut flower workshops, by investigating consumer behavior related to specialty cut flower workshops as an experience good. It investigates which experience good cues may be important for a consumer’s decision-making process. It introduces a Specialty Cut Flower Workshop Experience Map, which explains how potential participants move from first learning about a specialty cut flower workshop to their long-term behaviors as consumers. These findings help to provide marketing support for smaller-scale specialty crop farmers, specifically, specialty cut flower farmers.

Feasibility Of An Lgbtq+ Public Health Surveillance Platform In Kentucky: A Brief Report On Mental Health Signals, Keith J. Watts, Sydney Howard, Missy Spears, Carolyn Lauckner, Rachel H. Farr, Glenn Means, Justin X. Moore

Social Work Faculty Publications

Background/Objectives: Robust, state-level LGBTQ+ health surveillance is scarce in Kentucky, limiting evidence-based healthcare planning and policy. We aimed to evaluate the feasibility and early public-health utility of a community-partnered annual survey and compare selected mental health stressors between Kentucky and non-Kentucky respondents.

Methods: We conducted a cross-sectional online survey (13 April–15 July 2024) developed with a statewide LGBTQ+ nonprofit. Recruitment occurred via organizational channels and community events. A content warning preceded the survey, which was administered via Qualtrics. Data quality was screened using reCAPTCHA. We assessed feasibility metrics including recruitment and completion rates. Mental health stressors were captured …

Examining The Role Of Peer And Family Belongingness In The Mental Health Of Black Lgbtq+ Youth, Keith J. Watts, M. Alex Wagaman, Andrew D. Eaton, Vivian W. Y. Leung, Shelley L. Craig

Social Work Faculty Publications

A sense of belonging to familial and peer networks is crucial for the mental health of LGBTQ + youth. Black LGBTQ + youth report feeling rejected and isolated due to their sexual and/or gender identities. Utilizing linear regression analyses, this study explored the relationship between peer and family belongingness and levels of depression, anxiety, and self-rated mental health among 181 Black LGBTQ + youth in the United States and Canada. Findings suggest that family and peer belongingness are important factors in Black LGBTQ + youth’s mental health and warrant further study into the protective nature of peer and family relationships …

Environmental Health Priorities In Rural Public Health Departments: Perspectives From Health Agency Directors, Michelle Rastegar

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Rural communities are staffed by environmental health practitioners with less formal public health training and fewer years of public health experience. The literature on environmental health program implementation in rural communities is incomplete and specifically misses the perspectives of those charged with developing and fielding such programs. The purpose of this paper is to gather and report the insights of three rural local public health department leaders regarding the challenges, opportunities and stakeholders for implementing environmental health programs. Using purposive sampling of faculty community partners, three rural Kentucky local health department directors were recruited to participate in the study. After …

Promoting Physical Activity (Pa) Among Latinas In Fayette County, Ky, Vanessa Diaz Mph

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

In the United States, the prevalence of overweight and obesity continues to rise at a disproportionate rate that is greatly affecting Latinas. This paper outlines the implementation of an adapted version of Fe en Acción, a faith-based evidence-based physical activity (PA) intervention that was initially implemented in San Diego, CA. The program targets Latinas in Fayette County, KY through culturally tailored, faith-based PA classes held at local Catholic churches. By using promotoras– health promoters– the program works to increase self-efficacy and social support while promoting sustainable behavior change. Key adaptations include a reduction in class frequency (four times a week), …

Pathways To Green River District Health Department, Gracelyn P. Bush

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

In an effort to decrease Neonatal Abstinence Syndrome (NAS) in the Green River District of Western Kentucky, this grant proposes the expansion of the evidence-based University of Kentucky PATHways program to the Green River District Health Department (GRDHD). To protect the health of both women and children, this program will specifically target pregnant women with substance use disorder (SUD). This program will deliver a group-based prenatal and postpartum curriculum with the integration of Peer Recovery Support Specialists, specifically modeled on Social Cognitive Theory and the adoption of whole-person care. The proposed program spans a three-year time frame, beginning with program …

A Case Study In Program Evaluation: Evaluation Of A Community Program To Increase Rates Of Physical Activity, Emma Hughes

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Bourbon County faces rates of obesity and levels of physical inactivity that are at, or worse, than the Kentucky state average. The Bourbon County Health Department (BCHD) has prioritized addressing these issues and received funding from a private foundation to do so. Collaboration with the University of Kentucky and additional funding from UK Healthcare (UKHC) will support these efforts to improve the rates of regular physical activity, raise awareness of the negative health impacts of inactivity, and increase access to safe places to exercise. The BCHD developed a 6-month program that involves several interventions aimed at increasing the percent of …

An Ethnography Of Love Jihad: The Governance Of Interfaith Marriages In Times Of Hindutva, Snehal Sharma

Theses and Dissertations--Gender and Women's Studies

My doctoral research focuses on the violations of human and citizenship rights of women and religiously marginalized communities (based on religious differences) in the backdrop of right-wing movements in India. I assess the Hindu nationalist propaganda named “love jihad” to demonstrate the way it weaponizes religious exogamy. This propaganda legitimizes violence against Indian religious minorities and women as it claims that marriages between Hindu women and Muslim men are acts of terrorism against Hindus with the sole aim of increasing the Muslim population using Hindu women's bodies. I have used ethnographic research methods to explore the legal process of interfaith …

Pathways To Financial Wellness: Using Intersectionality Theory To Understand Black Women’S Financial Socialization, Courtney J. Wright

Theses and Dissertations--Educational, School, and Counseling Psychology

Black women experience high levels of financial vulnerability and consistently exhibit poor financial outcomes across the literature; however, few studies have investigated Black women’s financial socialization processes and outcomes. As a function of gendered racial marginalization, Black women occupy a unique standpoint that may influence their financial socialization experiences. Therefore, research that investigates Black women’s financial socialization and perceived financial capability, responsibility, and well-being is warranted.

Within this dual-manuscript style dissertation, the first manuscript investigates the sources, content, and methods of Black women’s family financial socialization messages. Using a critical-constructivist research paradigm and Reflexive Thematic Analysis for data analysis, findings …

Developing Novel Therapeutic Strategies For Mcrc With A Brafv600e Mutation, Mariah Geisen

Theses and Dissertations--Toxicology and Cancer Biology

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. The overall incidence rates of CRC have decreased in those over 50, but there is an increasing incidence rate in those under 50. Risk factors for CRC include diet, family history, and a sedentary lifestyle. Early detection of CRC is key to patient survival and treatment response. Localized CRC has a survival rate of 90% and allows for surgical resection and chemotherapy. The 5-year survival for metastatic CRC (mCRC) is significantly reduced to around 14%. Despite early detection, 50% of patients will develop metastasis after surgical resection and …

Nf-Κb-Mediated Oxidative Stress Drives Cigarette Smoke-Induced Emt In Human Bronchial Cells, Sarah M. Alqithami

Theses and Dissertations--Toxicology and Cancer Biology

Cigarette smoke contains over 7,000 chemicals, many being carcinogens and proinflammatory agents contributing to chronic respiratory diseases like COPD and lung cancer. This study investigated responses of human bronchial epithelial cells (HBECs) to cigarette smoke condensate (CSC), focusing on oxidative stress and NF-κB signaling. Three HBEC lines were exposed to non-cytotoxic CSC doses for 48 hours, inducing morphological changes consistent with epithelial-to-mesenchymal transition (EMT). RNA sequencing revealed transcriptomic shifts in all cell lines, particularly affecting genes related to oxidative stress, inflammation, hypoxia, and metabolism. Enrichment analyses confirmed activation of NRF2 antioxidant, NF-κB and IL-17 inflammatory, and hypoxiainducible factor pathways, indicating …

Elucidating The Adverse Effects Of Chronic Pfos Exposure On Gastrointestinal Pathology And Colorectal Cancer, Jerika Durham

Theses and Dissertations--Toxicology and Cancer Biology

Commonly referred to as "forever chemicals," per- and polyfluoroalkyl substances (PFAS) have been linked to a number of detrimental health effects, including an elevated risk of cancer. One "long-chain" subtype of PFAS, perfluorooctanesulfonic acid (PFOS), has a long elimination half-life and a significant propensity for bioaccumulation. Because PFOS is commonly found in drinking water, the gastrointestinal system absorbs it at a high rate. Recent studies demonstrate that PFAS exposures promote intestinal inflammation and gut barrier dysfunction. However, how a long-term PFOS exposure affects colorectal cancer (CRC) progression is not known. Therefore, the purpose of this research is to understand how …

Investigating Plk1 In Pulmonary Fibrosis, Tempany Arbogast

Theses and Dissertations--Toxicology and Cancer Biology

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease, with a median survival of only 2–3 years following diagnosis. In the United States, the disease contributes to more than 40,000 deaths annually, underscoring its severe clinical burden. Alveolar type II (AT2) lung epithelial cells serve as progenitors that maintain alveolar integrity by replenishing epithelial populations and producing surfactants, while fibroblasts and myofibroblasts regulate the extracellular matrix and structural support. In pulmonary fibrosis (PF) injury to AT2 cells promotes cytokine and growth factor release, driving inflammation, fibroblast proliferation, myofibroblast accumulation, and excessive extracellular matrix deposition. Aberrant AT2 cell …

Forage News [2025-02], University Of Kentucky

Forage News

No abstract provided.

Forage News [2025-12], University Of Kentucky

Forage News

No abstract provided.

Forage News [2025-05], University Of Kentucky

Forage News

No abstract provided.

Forage News [2025-03], University Of Kentucky

Forage News

No abstract provided.

Predicting Biologic Nonadherence In Inflammatory Bowel Disease Using Machine Learning Models, Christian Rhudy

Theses and Dissertations--Clinical and Translational Science

Inflammatory bowel disease is a chronic relapsing-remitting disease of the intestinal tract affecting approximately 0.5% of the population in the US. Moderate to severe inflammatory bowel disease is managed with biologic therapies to induce and maintain remission, however nonadherence to biologics occurs in and estimated 16.9% and 45% of patients. Nonadherence to biologics can increase the risk of disease flares, emergent healthcare utilization, and surgical intervention. While numerous factors have been associated with biologic nonadherence, there are limited resources for prospectively assessing patient-specific risk of biologic nonadherence. Accordingly, objective of this work is to develop machine learning methods of predicting …

Association Of State Cannabis Legalization With Cannabis Use Disorder And Cannabis Poisoning, Jayani Jayawardhana, Jialin Hou, Patricia Freeman, Jeffery C. Talbert

Health Management and Policy Faculty Publications

IMPORTANCE Whether state implementation of medical and recreational cannabis laws is associated with increased cannabis use disorder (CUD) and/or cannabis poisoning among adults is not evident.

OBJECTIVE To examine state-level medical and recreational cannabis laws’ associations with CUD and cannabis poisoning, overall and by sex and age subgroups.

DESIGN, SETTING, AND PARTICIPANTS In this longitudinal cohort study, state-level CUD and cannabis poisoning diagnoses from January 2011 to December 2021 were examined across all 50 US states and the District of Columbia before and after the implementation of medical and recreational cannabis laws (MCLs and RCLs, respectively) using a staggered adoption …

Demographic Variation In Continuous Glucose Monitoring Utilisation Among Patients With Type 1 Diabetes From A Us Regional Academic Medical Centre: A Retrospective Cohort Study, 2018–2021, Omer Atac, Kory R. Heier, Daniela Moga, John L. Fowlkes, Min-Woong Sohn, Aaron J. Kruse-Diehr, Teresa M. Waters, Mary E. Lacy

Health Management and Policy Faculty Publications

Objective: While continuous glucose monitoring (CGM) utilisation has been increasing among patients with type 1 diabetes (T1D), few studies have examined patterns of use across age, race/ethnicity and insurance status together. In this study, we examine CGM utilisation among patients with T1D from a regional academic medical centre across all insurance types.

Design and Setting: This is a retrospective cohort study including both paediatric and adult patients with T1D who visited a regional academic medical centre between 1 January 2018 and 31 December 2021.

Methods: Patients were followed from the date of their first T1D encounter during the study period …

“A Safe Place”: Exploring Black Couples’ Perceptions Of Black Love And Relationship Coping In The Context Of Their Lived Experiences With Racism, Melinda Murdock

Theses and Dissertations--Family Sciences

Historically, Black couples have not been studied within the context of their lived experiences as it relates to the effects of racism on relationship health. Only in the last decade have relationship scholars begun to consistently link racism-related stressors to relationship processes and outcomes. Despite the growing literature, recent studies are primarily quantitative in method and rely on samples, theoretical models, and measures that predominantly represent White couples’ experiences. It remains unclear how Black couples’ perceptions of love and relationship coping lead to resilient outcomes despite the negative effects of racism.

Therefore, the goal of the present study is to …

Plasma S100Β Is A Predictor For Pathology And Cognitive Decline In Alzheimer’S Disease, Geetika Nehra, Bryan J. Maloney, Rebecca Smith, Wijitra Chumboatong, Erin L. Abner, Peter T. Nelson, Björn Bauer, Anika M. S. Hartz

UK CARES Faculty Publications

Background Blood–brain barrier dysfunction is one characteristic of Alzheimer’s disease (AD) and is recognized as both a cause and consequence of the pathological cascade leading to cognitive decline. The goal of this study was to assess markers for barrier dysfunction in postmortem tissue samples from research participants who were either cognitively normal individuals (CNI) or diagnosed with AD at the time of autopsy and determine to what extent these markers are associated with AD neuropathologic changes (ADNC) and cognitive impairment.

Methods We used postmortem brain tissue and plasma samples from 19 participants: 9 CNI and 10 AD dementia patients who …

Artesunate Enhances The Efficacy Of Enzalutamide In Advanced Prostate Cancer, Xinyi Wang, Jinghui Liu, Fengyi Mao, Yifan Kong, Qiongsi Zhang, Chaohao Li, Daheng He, Chi Wang, Yanquan Zhang, Ruixin Wang, Sally R. Ellingson, Qiou Wei, Zhiguo Li, Xiaoqi Liu

Toxicology and Cancer Biology Faculty Publications

Prostate cancer (PCa) is one of the leading causes of death among men worldwide. Treatments targeting the androgen receptor pathway remain the standard therapy for PCa patients. Enzalutamide (ENZ), a second-generation androgen receptor inhibitor, was developed to treat castration-resistant prostate cancer. However, while patients initially respond to ENZ, drug resistance typically develops within a few months. Artesunate (ART), a semisynthetic derivative of the Artemisinin plant, is approved for antimalaria treatment. In this study, we conducted an FDA-approved drug screening and identified ART as a potential candidate for overcoming ENZ resistance in PCa. Mechanistically, ART induces the degradation of c-Myc, enhancing …

Current Practices In Training Paraeducators: A Literature Review, Rebekah Pearson

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

I conducted a brief literature review to examine current practices for training paraeducators in school settings. I reviewed literature published after 2010 using an online database. Using an author-made inclusion criterion, 13 articles were considered for review. Findings suggest that behavior skills training (BST), brief performance feedback, didactic training, and a strategy instruction framework are currently being used to train paraeducators. These trainings have yielded positive results in increasing desired paraeducator behaviors. I conclude by discussing the limitations and directions for future research.

Impacts Of School-Based Agricultural Education On The Resilience Of Senior Appalachian High School Students Living In Economically Disadvantaged Counties In Kentucky And Virginia, Ruth D. Toole

Theses and Dissertations--Community & Leadership Development

Students in Central Appalachia, particularly those in economically disadvantaged (ED) counties, may face unique risks related to their geographic and socioeconomic circumstances. However, school-based and youth development programs have been shown to foster resilience among youth. This convergent mixed-methods study aimed to explore whether involvement in School-Based Agricultural Education (SBAE) can enhance youth resilience. Data were collected through a resilience questionnaire and semi-structured focus group interviews, which were analyzed, interpreted, and integrated to uncover key findings. Results indicated that participants living in ED areas exhibited relatively high resilience scores. Focus group discussions revealed that, despite the challenges they face, participants …

Metformin In Overcoming Enzalutamide Resistance In Castration-Resistant Prostate Cancer, Kendall Simpson, Derek B. Allison, Daheng He, Jinpeng Liu, Chi Wang, Xiaoqi Liu

Markey Cancer Center Faculty Publications

Androgen deprivation is the standard treatment for patients with prostate cancer. However, the disease eventually progresses as castration-resistant prostate cancer (CRPC). Enzalutamide, an androgen receptor inhibitor, is a typical drug for treating CRPC and with continuous reliance on the drug, can lead to enzalutamide resistance. This highlights the necessity for developing novel therapeutic targets to combat the gain of resistance. Metformin has been recently investigated for its potential antitumorigenic effects in many cancer types. In this study, we used enzalutamide and metformin in combination to explore the possible rescued efficacy of enzalutamide in the treatment of enzalutamide-resistant CRPC. We first …

Portable Multi-Parametric Microscopy For Noninvasive Metabolic And Vascular Imaging Of Orthotopic Tongue Cancer Models In Vivo, Pranto Soumik Saha, Jing Yan, Caigang Zhu

Markey Cancer Center Faculty Publications

Significance: Precise imaging of tumor metabolism with its vascular microenvironment becomes emerging critical for cancer research because increasing evidence shows that the key attribute that allows a tumor to survive therapies is metabolic and vascular reprogramming. However, there are surprisingly few imaging techniques available to provide a systems-level view of tumor metabolism and vasculature in vivo on small animals for cancer discoveries.

Aim: We aim to develop a new multi-parametric microscope that can faithfully recapitulate in vivo metabolic and vascular changes with a wide field of view and microscope-level resolution to advance cancer-related investigations. To maximize the ease and accessibility …