Digital Commons Network^™

Proto-Oncogene Hras Transcript Level And Overall Survival In Stages Ii And Iii Colorectal Cancer, Donghyun Kim, Saima Sharif, Juan Antonio Raygoza Garay, Avanish S. Bhakta, Patrick M. Boland, Michael J. Cavnar, Michelle L. Churchman, Hassan Hatoum, Lyen C. Huang, Joseph Kim, Richard Kim, Robert W. Lentz, Sarbajit Mukherjee, Mary T. O'Donnell, Benjamin Quartey, Matthew J. Reilley, Robert J. Rounbehler, Bodour Salhia, Bryan P. Schneider, Carlos H. Chan

Surgery Faculty Publications

Background: Mutational landscape is prognostic in colorectal cancer (CRC). Rat sarcoma (RAS) oncogenes, such as KRAS and NRAS, with driver mutations, portend poor survival outcomes, whereas pathologic mutations in HRAS are extremely rare, and their prognostic value remains uncertain. Methods: This retrospective study analyzed the Oncology Research Information Exchange Network (ORIEN) alliance tumor RNA-Seq data in Stages II and III CRC to investigate the association between RAS gene expression and survival outcomes. Results: High transcript levels of HRAS were associated with superior overall survival (OS). The high HRAS-associated OS benefit was most pronounced in patients with right-sided primary expressing low …

Social Trends Emerging In A Mexican Village Community Involved In A Leaf Nutrient Supplementation Project Offered As Nutritional Intervention Scheme, T M. Ostrowski-Meissner, H T. Ostrowski-Meissner

IGC Proceedings (1977-2023)

Social analysis of the leaf nutrient supplementation (LNS) project using protein concentrate from alfalfa in a Mexican village (Saltillo) has been made in an attempt to identify the social trends associated with the community's involvement with protein extraction from green vegetation as a nutritional intervention scheme. Through preliminary on site observation and review of available scheme records, emergent social trends were identified in:

1. the voluntary diversification of nutritional habits,

2. an extension of health services for the community, and

3. subtle change within the village social milieu. The suitability of the LNS project is discussed, and areas for further …

Effects Of Fluidized Bed Combustion Residue Application To Reclaimed Mine Land On Yield And Composition Of Forage And Performance Of Grazing Steers, K O. Smedley, J P. Fontenot, V G. Allen, H D. Perry, O L. Bennett

IGC Proceedings (1977-2023)

Fluidized bed combustion residue (FBCR), a waste product resulting from the addition of limestone to coal prior to combustion, is high in sulfur (S) and has approximately 50% of the neutralizing capacity of limestone. Research was conducted to study effects of repeated applications of FBCR to pastures on forage yield and composition, and on performance and health of grazing cattle. Three treatments were applied in three replicated .81 ha pastures located on acidic reclaimed land which had been previously mined by mountain top removal. Treatments were control, dolomitic limestone (3380 kg/ha) and FBCR (6760 kg/ha), applied in split applications. Pastures …

Protein Structure Influences Redox Stability, Oxygen Affinity, And Heat-Induced Denaturation Properties Of Bovine Myoglobin, Hemoglobin, And Cytochrome C, Anuj Sharma, Runnan Li, Silan Bhandari, Surendranath P. Suman, Sadagopan Krishnan, Morgan Pfeiffer, Gretchen Mafi, Ranjith Ramanathan

Animal and Food Sciences Faculty Publications

While past research has predominantly focused on the role of myoglobin in meat color, investigations into the contributions of hemoglobin and cytochrome c are limited. Cytochrome c has the highest redox stability (P < 0.05), followed by myoglobin and hemoglobin. Electrochemistry analysis revealed that cytochrome c has a greater capacity (P < 0.05) to reduce than myoglobin and hemoglobin. Differential scanning calorimetry indicates that cytochrome c was most stable to heat (P < 0.05), while no differences were noted between myoglobin and hemoglobin. Structural analysis noted that greater heat and redox stability of cytochrome c might be attributed to fewer histidine residues (3) and more covalent bonds (4) than myoglobin (13), hemoglobin α (10), and hemoglobin β (6). This study suggests that the amino acid sequence and number of covalent bonds can impact the redox stability and heat-induced denaturation properties of myoglobin, hemoglobin, and cytochrome c.

The International Soft Tissue Sarcoma Consortium, Gianni Bisogno, Monika Sparber-Sauer, David Rodeberg, Johannes H.M. Merks, Ewa Koscielniak, Suzanne L. Wolden, Gian Luca De Salvo, Paola Del Bianco, Wei Xue, Martin Ebinger, Christian Vokuhl, Rajkumar Venkatramani, Samuel L. Volchenboum, Brian Furner, Veronique Minard Colin, Douglas S. Hawkins

Surgery Faculty Publications

Background: The International Soft Tissue Sarcoma Consortium (INSTRuCT) was established in 2017 to enhance international collaboration. This study describes the characteristics of rhabdomyosarcoma (RMS) patients in the INSTRuCT database and examines differences across contributing groups. Methods: INSTRuCT includes data Children’s Oncology Group (COG), Cooperative Weichteilsarkom Studiengruppe (CWS), and European Paediatric Soft Tissue Sarcoma Study Group (EpSSG) along with prior studies from Malignant Mesenchymal Tumour Committee (MMT) and Italian Soft Tissue Sarcoma Committee (STSC). Data standardization was supported by the University of Chicago’s Pediatric Cancer Data Commons. Pseudonymized patient-level data from clinical trials were harmonized. Differences across groups were assessed using …

The Kentucky Microbiome Dataset, Rachel L. Washburn, Douglas C. Curl

Research Data--KGS

The Kentucky Microbiome Dataset is a continuously updated geolocated dataset which describes the distribution and diversity of microorganisms across the Commonwealth of Kentucky. Each geolocated point represents a location reported in the peer-reviewed literature where microorganisms were sampled from soil, water, geologic substrates, or clinical settings. Environmental studies include only non-host-associated, non-clinical microorganisms sampled from natural environments. Clinical studies are mapped separately to highlight locations where investigations into host-associated or human health-related microbes have occurred.

For each location, associated metadata include study information, taxonomic classifications, sample type, sampling method, latitude and longitude, sampling date, publication reference, and a direct link …

Receptor-Mediated Spion Labeling Of Cd4+ T Cells For Longitudinal Mri Tracking Of Distribution Following Systemic Injection In Mouse, Yu Ping, Songyue Han, Brock Howerton, Francesc Marti, Jake Weeks, Roberto Gedaly, Reuben Adatorwovor, Fanny Chapelin

Surgery Faculty Publications

Tracking T cells in vivo using MRI is a major challenge due to the difficulty of labeling these non-phagocytic cells with a sufficient contrast agent to generate a detectable signal change. In this study, we explored CD4-Superparamagnetic iron oxide nanoparticles (SPION), which is commonly used in magnetic cell sorting, as a potential receptor-mediated, specific CD4+ T cell MRI labeling agent. We optimized the labeling protocol for maximal CD4+ cell labeling and viability. Cell health was confirmed with trypan blue assay, and labeling efficacy was confirmed with Prussian blue staining, transmission electron microscopy, and MRI of labeled cell pellets. Key cell …

Effects Of The Communities That Heal Intervention On Initiation, Retention, And Linkage To Medications For Opioid Use Disorder (Moud), Jennifer L Brown, Marc R Larochelle, Laura C Fanucchi, Deirdre C Calvert, Aimee N C Campbell, Redonna K Chandler, Daniel J Feaster, Lashawn M Glasgow, Erin B Gibson, Janae Holloway, Michelle R Lofwall, Aimee Mack, Nicole Mack, Edward V Nunes, Jeffery C Talbert, Sylvia Tan, Nathan Vandergrift, Jennifer Villani, Kat Asman, Hermik Babakhanlou-Chase, Sarah M Bagley, Tracy A Battaglia, Derek Blevins, Carly Bridden, Debbie M Cheng, Mia Christopher, Lindsay W Cogan, Chinazo O Cunningham

Biostatistics Faculty Publications

Medications for opioid use disorder (MOUD) can reduce opioid use and overdose deaths. This study examined whether the Communities That HEAL (CTH) intervention increased MOUD initiation, retention, and linkage. The HEALing Communities Study was a multi-site, 2-arm, parallel, community-level, cluster-randomized, unblinded, wait-list controlled trial conducted in 67 communities (n = 34 intervention, n = 33 control). Using Prescription Drug Monitoring Programs and Medicaid claims data, we compared mean community-level rates of MOUD outcomes during the 1-year comparison period (July 2021-June 2022) for: (a) MOUD receipt at least once; (b) continuous MOUD receipt for 180 days; and (c) MOUD linkage within …

Adverse Birth Outcomes Associated With Heat Stress And Wildfire Smoke Exposure During Preconception And Pregnancy, Roxana Khalili, Yisi Liu, Yan Xu, Karl O’Sharkey, Nathan Pavlovic, Crystal Mcclure, Fred Lurmann, Tingyu Yang, Xinci Chen, Mario Vigil, Brendan Grubbs, Layla Al Marayati, Deborah Lerner, Nathana Lurvey, Carmen J. Marsit, Jill Johnston, Theresa M. Bastain, Carrie V. Breton, Shohreh F. Farzan, Rima Habre

Epidemiology and Environmental Health Faculty Publications

We investigated associations between preconception and prenatal heat stress and wildfire (WF) smoke exposures on adverse birth outcomes and whether neighborhood climate vulnerability is an effect modifier in the Maternal And Developmental Risks from Environmental and Social stressors cohort (N = 713). Generalized linear models were fit to test the association between exposures and small-for-gestational-age (SGA), low birthweight (LBW), and Fenton growth z-score outcomes, adjusting for confounders. Living in a high climate vulnerability index neighborhood was tested as an effect modifier. During preconception, increases in heat stress and WF measures were associated with higher odds of SGA. Living in the …

Associations Of Hepatitis C Virus (Hcv) Antibody Positivity With Opioid, Stimulant, And Polysubstance Injection Among People Who Inject Drugs (Pwid) In Rural U.S. Communities, Angela T. Estadt, William C. Miller, David Kline, Bridget M. Whitney, April M. Young, P. Todd Korthuis, Thomas J. Stopka, Judith Feinberg, William A. Zule, Mai T. Pho, Peter D. Friedmann, Ryan P. Westergaard, Kellene V. Eagen, Andrew Seaman, Jimmy Ma, Vivian F. Go, Kathryn E. Lancaster

Epidemiology and Environmental Health Faculty Publications

Background: People who inject drugs (PWID) in the rural U.S. often inject stimulants, alone or with opioids. The impact of these substance use patterns may influence HCV risk behaviors. This analysis examines the associations of HCV antibody positivity with injecting only opioids, only stimulants (methamphetamine/cocaine), and opioids and stimulants together among rural PWID. Methods: The Rural Opioid Initiative (ROI) consists of eight research sites that enrolled people who use drugs in rural communities in ten U.S. states from 2018 to 2020. This cross-sectional analysis included adult participants who resided in a study area and injected any drug in the past …

The Effects Of Parental Occupational Exposures On Autism Spectrum Disorder Severity And Skills In Cognitive And Adaptive Domains In Children With Autism Spectrum Disorder, Erin C. Mccanlies, Ja Kook Gu, Claudia C. Ma, Wayne T. Sanderson, Yunin J. Ludeña-Rodriguez, Irva Hertz-Picciotto

Epidemiology and Environmental Health Faculty Publications

No abstract provided.

Enhanced Pavement Project Prioritization, Bryan Gibson, Jon Wilcoxson, Gayle Marks

Kentucky Transportation Center Research Report

The Kentucky Transportation Cabinet (KYTC) is responsible for inspecting, maintaining, and improving 27,000 centerline miles of pavement. Given the vastness of the state’s transportation network, KYTC needs a robust method for prioritizing pavement preservation projects. The Cabinet has relied on pavement condition ratings, data collected using Laser Crack Measurement Systems, and input from district-level staff to prioritize these types of projects. But this approach overlooks information that should be considered, such as factors related to safety, mobility, and geographic context. To resolve these shortcomings, Kentucky Transportation Center (KTC) researchers worked with KYTC subject-matter experts to develop the Enhanced Pavement Prioritization …

Who Reconstitutes The Chemotherapy? The Educational And Practice Needs Of Oncology Pharmacists In West Africa: A Call For Multidisciplinary Team Approach In Oncology Care., Runcie C.W. Chidebe, Ramatu M. Alabelewe, Krishna Prasad Sapkota, Darlingtina K. Esiaka, Candidus C. Nwakasi, Gloria C. Okwu, Jacinta Emejulu, Adamu A. Umar, Ndifreke Okwuegbunam, Funsho David, Toyosi Adepoju, Agha A. Agha, Ejike S. Ugwu, Simeon C. Aruah, Richard Mshelia, Rob Duncombe, Noel N. Wannang, Peace C. Babalola, R. Donald Harvey, Cindy O'Bryant, Folakemi T. Odedina

Behavioral Science Faculty Publications

PURPOSE: Oncology pharmacists (OPs) play a crucial role in cancer care, treatment, survivorship, and multidisciplinary teams (MDTs). OPs have specialized training in designing, administering, monitoring, and modifying oncology chemotherapy; managing adverse events; and evaluating clinical trials and investigational drugs. Yet, the state of OP has remained largely unknown in the clinical oncology workforce of the West African region. Therefore, this study aimed to understand who reconstitutes chemotherapy and to explain the OP educational and practice needs, challenges, and solutions in Nigeria.

MATERIALS AND METHODS: Using a concurrent embedded mixed method design, 35 OPs completed a questionnaire, and 12 others responded …

Longitudinal Imaging Of The Parafoveal Cone Mosaic In Congenital Achromatopsia, Nickolas Chen, Katie M. Litts, Danica Nikezic, Christopher S. Langlo, Brian P. Higgins, Byron L. Lam, Gerald A. Fishman, Frederick T. Collison, Mark E. Pennesi, Christine N. Kay, Sergey Tarima, Joseph Carroll

Biostatistics Faculty Publications

Purpose: To assess longitudinal changes in parafoveal cone density in individuals with congenital achromatopsia (ACHM). Design: Retrospective longitudinal study. Participants: Nineteen individuals (7 women and 12 men) with genetically confirmed ACHM. To be eligible, each had adaptive optics scanning light ophthalmoscope (AOSLO) images of the photoreceptor mosaic from ≥2 time points. Methods: For each individual, follow-up AOSLO montages were aligned to their baseline montage. Notably, 100 × 100 μm regions of interest (ROIs) were extracted from the split-detection modality at locations 1°, 5°, and 10° temporal (T) from the peak cone density in each montage. All ROIs from follow-up visits …

Genetically Proxied Blood Pressure, Vascular Brain Injury, And Alzheimer's Disease Pathology, Iyas Daghlas, Michelle R. Caunca, Lincoln M.P. Shade, Malik Nassan, Kristine Yaffe, David W. Fardo, Dipender Gill

Biostatistics Faculty Publications

INTRODUCTION: Lower blood pressure (BP) is linked to reduced dementia risk, though it is uncertain whether this benefit stems solely from mitigating vascular brain injury (VBI) or also extends to directly influencing Alzheimer's disease (AD) pathology. We leveraged Mendelian randomization (MR) to assess whether lifelong lower BP is causally associated with neuropathological correlates of VBI and AD. METHODS: We identified genetic proxies for systolic and diastolic BP (n = 1,028,980) and applied them in MR analyses of post mortem neuropathological measures of VBI and AD (n = 6363–7786). RESULTS: Genetically proxied lower systolic BP associated with reduced risk of all …

Step By Step, Patrick M. Filanowski, Jeremy A. Steeves, Emily Slade

Biostatistics Faculty Publications

Background/Objectives: Although public health organizations encourage family walking, no studies have examined children’s physical activity and enjoyment during outdoor parent–child walks. This study addresses those gaps by examining children’s moderate-to-vigorous physical activity (MVPA) and enjoyment during outdoor walks with their parents, along with parental barriers and their relationship with parent’s self-efficacy and co-activity minutes. Methods: Fifty parent–child dyads (children aged 6–12 years) completed 10 min, self-paced outdoor walks while wearing waist-worn ActiGraph monitors. Parents reported perceived barriers to walking outdoors with their child and self-efficacy for supporting their child’s daily physical activity. Results: Children reported high enjoyment (mean = 5.1 …

Endothelium- And Fibroblast-Derived C-Type Natriuretic Peptide Prevents The Development And Progression Of Aortic Aneurysm, Aisah A. Aubdool, Amie J. Moyes, Cristina Perez-Ternero, Reshma S. Baliga, Jaspinder Singh Sanghera, M. Taaha Syed, Kareemah Jaigirdar, Anmolpreet K. Panesar, Janice C. Tsui, Yanming Li, Hernan G. Vasquez, Ying H. Shen, Scott A. Lemaire, Juliette Raffort, Ziad Mallat, Hong S. Lu, Alan Daugherty, Adrian J. Hobbs

Physiology Faculty Publications

BACKGROUND: Thoracic (TAA) and abdominal (AAA) aortic aneurysm are life-threatening diseases characterized by dilation, inflammation, and structural weakness; development of pharmacological therapies is desperately needed. CNP (C-type natriuretic peptide) plays a key role in vascular homeostasis, mediating vasodilator, anti-inflammatory, and antiatherogenic actions. Since such processes drive AA, we determined the role of endogenous CNP in offsetting pathogenesis. METHODS: Tissue from patients with AA was analyzed to determine the consequences on CNP signaling. Ascending and suprarenal aortic diameters were assessed at baseline and following Ang II (angiotensin II; 1.44 mg/kg per day) infusion in wild-type, endothelium-restricted (ecCNP^-/-), fibroblast-restricted (fbCNP …

At The Nexus Between Epigenetics And Senescence, Toby L. Chambers, Jaden Wells, Pieter Jan Koopmans, Francielly Morena, Zain B. Malik, Nicholas P. Greene, Antonio Filareto, Michael Franti, Patrizia Sini, Harald Weinstabl, Robert T. Brooke, Milda Milčiūtė, Juozas Gordevičius, Steve Horvath, Yuan Wen, Cory M. Dungan, Kevin A. Murach

Physiology Faculty Publications

Senescent cells emerge with aging and injury. The contribution of senescent cells to DNA methylation age (DNAmAGE) in vivo is uncertain. Furthermore, stem cell therapy can mediate “rejuvenation”, but how tissue regeneration controlled by resident stem cells affects whole tissue DNAmAGE is unclear. We assessed DNAmAGE with or without senolytics (BI01) in aged male mice (24–25 months) 35 days following muscle healing (BaCl₂-induced regeneration versus non-injured). Young injured mice (5–6 months) without senolytics were comparators. DNAmAGE was decelerated by up to 68% after injury in aged muscle. DNAmAGE was modestly but further significantly decelerated by injury recovery with …

Carbohydrate Metabolism In The Intercaruncular Endometrium Is Affected By Form Of Supplemental Selenium At Maternal Recognition Of Pregnancy In Beef Heifers, Sarah N. Carr, Benjamin R. Crites, Kwangwon Son, Phillip J. Bridges

Animal and Food Sciences Faculty Publications

Selenium (Se)-deficient soils result in Se-deficient forages that do not meet the nutritional requirement for this trace mineral in grazing cattle. Supplementation of Se conventionally occurs through a basal vitamin/mineral mix containing Se in an inorganic form (ISe), although organic Se (OSe) is available when cattle graze on forage. We previously reported that the provision of supplemental Se as a 1:1 mixture of ISe:OSe (MIX), in contrast to the industry standard of ISe alone, increases early luteal phase concentrations of systemic progesterone (P4) and increases the length of the conceptus at day 17 of pregnancy. The objectives herein were to …

The Effects Of Heavy Metals Applied In Digested Sewage Sludge To Grassland, A Desira Buttigieg, D A. Klessa, D A. Hall

IGC Proceedings (1977-2023)

The application of potentially toxic elements in sewage sludge to grassland has implications to environmental pol­lution and the health of grazing rumiµants. In Scotland, mod­erately acid grassland receives most of the sewage sludge applied to agricultural land and there is therefore a risk of heavy metal mobilisation and uptake by herbage. In addition, soil ingestion (Fleming, 1986) and intake of herbage contami­nated with sludge adhering to leaf surfaces may present an important means by which potentially toxic elements are absorbed by ruminants. In this paper, two aspects of sewage sludge use on grassland are studied, namely : 1. Factors affecting …

Effects Of Sheep Grazing On Dry Matter Production And Persistence Of A Lucerne Crop, I Delgado Enguita

IGC Proceedings (1977-2023)

In Spain, lucerne is mainly grown on irrigated areas for hay production and dehydration industry. The utilization of lucerne under grazing is very infrequent, due to the detrimental effects on both, animal health and plants persistence that have been attributed to it. However, lucerne dry matter (DM) pro­duction and quality in addition of being its cultivation more economical than grasses, offer interesting advantages to be used as a green forage (Delgado, 1984). New Zealand workers (Agronomy Society of New Zealand, 1982) have stressed that lucerne could be successfully managed under grazing when long resting periods were provided between short grazing …

Determination Of The Forage Yield And Quality Of Native Hay At 3 Different Growth Stages At Syangboche Yak Farm, Nepal, D Pariyar, C Samuel

IGC Proceedings (1977-2023)

The Syangboche Yak Farm is situated within the Sagarma­tha National Park in the district of Solukhumbu, eastern Nepal. The farm comprises 7 pasture areas stituated at different locations ranging from 3700 m. to 5700 m. The total farm area is 900 ha. and the pastures, situated at different heights, are used for grazing during specific periods of the month extending throughout the year. The size of the pastures varies from 15 to 250 ha. About 80 yaks pass their winters from November to May every year on a small pasture area of 15 ha at the farm proper at 3700 …

Effect Of Endophyte (Acremonum Coenophialum) Infection Of Tall Fescue And Paddock Exchange On Intake And Performance Of Grazing Steers, J A. Stuedmann, D L. Breedlove, K R. Pond, D P. Belesky, L P. Tate Jr, F N. Thompson, S R. Wilkinson

IGC Proceedings (1977-2023)

INTRODUCTION Tall fescue (Festuca arundinacea Schreb), grown on over 14 million ha, is the most common pasture grass in humid areas of the eastern USA and, to limited extent, in the northwestern USA. The presence of an endophyte in tall fescue has been associated with a number of animal health problems including reduced performance (Stuedemann and Hoveland, 1988). Intake was reduced in diets containing the endophyte in seed, hay or green forage (Hemken et al., 1979; Schmidt et al., 1982). However, no studies have been reported which used direct methods to determine intake differences of grazing animals as influenced …

Year-Round Grazing Systems For Beef Production From Conception To Slaughter, V G. Allen, J P. Fontenot, W P. Green, R C. Hammes Jr

IGC Proceedings (1977-2023)

Throughout much of the world cattle are produced mainly on forage. High grain yields in the U.S. have led to feeding cat­tle high grain to minimize time in the feedlot, and overhead costs. Recent emphasis on lean meat, diet and health issues has renewed interest in finishing cattle on forages. The objective of this research was to evaluate various forage systems of beef production from conception through slaughter with minimum grain. Effects of forage system during cow-calf and growing phases on performance and carcass characteristics during the finishing phases were evaluated. The research included calves born in late winter-early spring …

The Use Of Improved Pastures By Grazing Dairy Cows For Economic Milk Production In Thailand, C Lekchom, K Witayanuparpyunyong, P Sukpituksakul, B R. Watkin

IGC Proceedings (1977-2023)

Dairy farming is a relatively new agricultural industry in Thailand and has shown a rapid and dramatic development over the past decade. During this period dairy cattle numbers have trebled (from approx. 20,000 to 60,000) and the number of dairy farmers has quadrupled (approx. 2,000 to 8,000). With the present positive support from the Government this explos­ive development is likely to continue. While the price of milk paid to the farmers over this period had been good there has, nevertheless, been a substantial increase in the variable on-farm costs of production which is squeezing the farmer profit margin significantly and …

Rcpneoperu Trial: A Cluster Randomized Pilot Trial To Assess Traditional Neonatal Resuscitation Compared To Partially Virtual Training In Remote Areas., Carlos A Delgado, Enrique Gómez Pomar, Pablo Velásquez, Víctor Sánchez, Roberto Shimabuku, Luis Huicho

Pediatrics Faculty Publications

OBJECTIVE: To assess the effects of a neonatal resuscitation training program using traditional training and partial distance learning.

METHOD: Through an open cluster-randomized trial, the authors compared a traditional approach involving face-to-face theory and practice sessions using information and communication technology to offer theory and distance examination, followed by face-to-face practice. Twelve health facilities were allocated by blocked randomization. Comparisons were made adjusting for clustering in qualitative and quantitative data. The primary outcome was the percentage of infants with heart rates ≥100 per minute at the second minute after birth. The authors performed a cluster-level analysis for cluster randomized trials, …

The Rhetoric Of Responsibilization: A Rhetorical Analysis Of Pre-Exposure Prophylaxis Campaigns For Hiv Prevention, Catherine M. Pabalate

Kentucky Undergraduate Journal for the Health Humanities

Responsibilization refers to the process by which patients are made accountable for their health and wellbeing, which is determined by their habits and behaviors. Though responsibilization affords greater agency to patients, it can also result in anxiety and guilt when the patient appears "deviant" or "noncompliant." Because sexual behavior is attributed to the causality of HIV/AIDS, patients’ sexual patterns and choices are included within their medical decision-making. This rhetorical analysis focuses on pharmaceutical campaigns and commercials for pre-exposure prophylaxis (PrEP), which were released between 2012 and 2024 and are targeted towards patients at-risk for HIV/AIDS. Findings suggest that specific rhetorical …

Association Of Fentanyl Test Strip Results And Change In Drug Use Behaviors, Kitty H Gelberg, Nabila El-Bassel, Denise C Babineau, Rachel A Vickers-Smith, Laura C Fanucchi, Janet E Childerhose, Megan E Hall, Megan E Dzurec, Jennifer Villani, Mary R Russo, Patricia Lebaron, Katherine R Marks, Kathyrn E Lancaster, Louisa Gilbert, James L David, Barry S Eggleston, Carter A Roeber, Emmanuel A Oga, Redonna K Chandler, Sharon L Walsh

Epidemiology and Environmental Health Faculty Publications

BACKGROUND: The Stay Safe Study, conducted between May and December 2023 in the United States, investigated the association between fentanyl test strip (FTS) use and risk reduction behaviors. This paper examines the association between self-reported FTS results and change in drug use behaviors.

METHODS: We solicited self-reported drug and FTS use among people who use drugs (PWUD), with a baseline and four weekly surveys over a 28-day observation period in three states (Kentucky, New York and Ohio). For each day participants reported drug use, they were asked types of drugs used, use of FTS, FTS results, and 12 drug use …

How To Gender Include, Stephen Krueger

Library Faculty and Staff Publications

Gender inclusion is not an optional part of library work—at least, it isn’t if we want all those “Libraries Are For Everyone” signs to be true. And yet, the reality is that many libraries fail the most basic aspects of gender inclusion for patrons, employees, or both. Even in libraries where Trans 101 trainings do occur and are well received, or where the baseline of knowledge among employees is relatively high, the question remains: What now?

This article intends to answer that question. Very broadly speaking, gender inclusion work in libraries means sustained action to ensure that some patrons and …

A Single-Blind, Randomized, Controlled Contingency Management Trial On Physiological Indices And Biomarkers Of Cardiovascular Health In People With Cocaine Use Disorder, William W. Stoops, Thomas P. Shellenberg, Sean D. Regnier, David H. Cox, Reuben Adatorwovor, Lon R. Hays, Danielle M. Anderson, Joshua A. Lile, Joy M. Schmitz, Jennifer R. Havens, Travis R. Sexton, Mary B. Fisher

Epidemiology and Environmental Health Faculty Publications

Introduction: Limited prospective research has evaluated the health benefits associated with changing levels of drug use, aside from complete abstinence. This study determined whether lower levels of cocaine use impacted physiological indices (e.g., mean arterial pressure) and biomarkers (e.g., stromal cell derived factor-1a [SDF-1a], soluble intercellular adhesion molecule-1 [ICAM-1], neutrophil activating peptide-2 [CXCL7]) of cardiovascular health. Methods: Treatment seeking participants enrolled in a 12-week single-blind, randomized, controlled cocaine contingency management trial. Participants were randomly assigned to High Value Reinforcers for cocaine abstinence (n = 41), Low Value Reinforcers for cocaine abstinence (n = 33) or a non-contingent Control group (n …