Digital Commons Network^™

Unsettling Refuge: Syrian Refugees’ Account Of Life In Denmark, Malene H. Jacobsen

Theses and Dissertations--Geography

This doctoral dissertation examines the lived experiences of refuge in Denmark from the perspectives of Syrian refugees. Situated within feminist political geography, it moves beyond examining geopolitics merely from the perspective of the law, the state, and policy makers. Instead, it seeks to grasp the ways in which geopolitics are encountered, experienced, and negotiated on the ground – by the people who are most affected by state policies and practices. It draws on more than ten months of ethnographic fieldwork in Denmark with Syrian refugees, including semi-structured interviews, focus groups, and participant observations, as well as interviews with state and …

Madness Narratives: Victorian Textual Responses To The Insanity Diagnosis, Jonathan Glenn Tinnin

Theses and Dissertations--English

In Madness Narratives, I examine four understudied texts at the intersection of Victorian asylums, patients’ lack of voice, and resistance narratives. I argue that these texts all reject the silencing power of the insanity diagnosis as they represent patients, former patients, and asylum reformers creating counternarratives that call for recognition of the patients’ humanity and right to be heard. In my first chapter, “Narrating Insanity: Constructing the Madness Narrative in Charles Reade’s Hard Cash,” I assert that Reade’s 1863 novel proposes a nuanced understanding of the insanity diagnosis as a collaboratively-composed story that justifies the confinement of the …

Modern Charity: Morality, Politics, And Mid-Twentieth Century Us Writing, Matt Bryant Cheney

Theses and Dissertations--English

Scholars over the past two decades (Denning, Szalay, Edmunds, Robbins) have theorized the different ways literature of the Mid-Twentieth Century reflects the dawn of the liberal US welfare state. While these studies elaborate on the effect rapidly expanding public aid had on literary production of the period, many have tended to undervalue the lingering influence on midcentury storytelling of private charity and philanthropy, those traditional aid institutions fundamentally challenged by the Great Depression and historically championed by conservatives. If the welfare state had an indelible impact on US literatures, so did the moral complexity of the systems of charity and …

The Idea Of Absolute Ethical Life: Hegel’S Account Of Freedom And Natural Law In His Early Philosophical Works, Tim Fitzjohn

Theses and Dissertations--Philosophy

This dissertation project focuses on G.W.F. Hegel’s early philosophical writings, though primarily on the Natural Law essay (1802/3), and how, through those writings, Hegel positions himself in relation to other thinkers, such as Fichte. Broadly, the modern period saw with it the rise of accounts of what is called natural law. Philosophers prior to Hegel argued that the proper account of natural law must be rooted in some kind of universal framework: either the basis of law must be the shared empirical facts of human nature (empiricism), or the basis of law must be found in the universal demands on …

Agricultural Livelihoods In Harlan County: A Case Study Approach Of Two Farms, Heather Kinney

Theses and Dissertations--Community & Leadership Development

This thesis explores agricultural livelihoods in Harlan County with two case studies in order to challenge dominant narratives about Eastern Kentucky. Harlan County, and Appalachia more broadly, is often written about in terms of its relationship to extractive industries. Absentee landownership in Appalachia has been well documented, especially in the case of coal counties. However, the relationship between extraction and agricultural livelihoods in Appalachia warrants more attention. The story of agricultural livelihoods in the region is often pushed to the periphery much like the practices of “hillside” farming. While geography makes much of the land unsuitable for farming in Harlan …

Constraints And Opportunities In Community-Led Food Justice Models, Teya Cuellar

Theses and Dissertations--Community & Leadership Development

Non-profits that do community-led food justice work with lower income communities face particular constraints and opportunities. This study examined those constraints and opportunities through participant observation of one such organization and interviews with four other organizations. Findings include the diversity of definitions for “community-led,” assets that can help or constrain the organization, and diversity in defining “scaling up” their organization models and missions. The organizations that heavily focused on lower income consumers noted tensions with the board of the non- profit and lack of engagement of consumers. I conclude by critiquing using language such as “models,” “scaling up,” or “replicating” …

The Role Of Place In Community Cooperative Food Markets In Lexington, Kentucky, Emily Rodes Spencer

Theses and Dissertations--Community & Leadership Development

Food justice movements focus on providing communities with local, sustainable, culturally appropriate, healthy food while empowering local economic systems that allow for autonomy of both producers and consumers (Caruso, C., 2014; Cadieux, K., 2015; Hayes, C. & Carbone, E., 2015). However, current food justice movements often price out and leave behind large portions of the population. Research has shown that engagement with local food systems contribute to feelings of place attachment and a sense of place (Solin, J., 2017; Alkon, A., 2011). The purpose of this study was to explore the relationship between volunteers at two alternative, cooperative community food …

Evaluation Of Air Movement In Equestrian Facilities And On Equine Athletes, Staci Elaine Mcgill

Theses and Dissertations--Biosystems and Agricultural Engineering

Ventilation and air movement are important aspects of animal agriculture and is frequently neglected in equine facilities. This paper discusses three different studies that examine different components of ventilation and air movement. One is a fan orientation study which examines how fans impact the stall environment, the second is a cooling study questioning whether forced air speed across a horse increases the rate of cool out after intense exercise, and the last is a survey examining ventilation, air quality, and health concerns in indoor arenas.

The stall fan study took place over two summers with the goal of determining how …

Removing Vehicle Speed From Apparent Wind Velocity, Austin M. Weiss

Theses and Dissertations--Biosystems and Agricultural Engineering

Variable-rate technologies for sprayer applications stand to increase efficacy by ensuring the right amount of chemical is applied at the right location. However, external environmental factors such as droplet drift caused by variable ambient condition, are not yet integrated into modern sprayer systems. Real-time wind velocity measurements can be used to control droplet spectra for reducing spray drift by actuating a variable-orifice nozzle. This work aimed to develop data processing methods needed to filter noise and remove vehicle speed from wind velocity measurements collected with an ultrasonic anemometer aboard a moving platform. Using a global navigation satellite system (GNSS), vehicle …

The Stimulation Of Dendritic Cells By Cationic Lipids, John Peyton Bush

Theses and Dissertations--Medical Sciences

The discovery that cationic lipids can independently stimulate the immune system has generated interest in their potential as vaccine adjuvants. Here, we show that the cationic lipid R-DOTAP can independently stimulate type 1 interferon production in dendritic cells in both primary culture and immortalized cell culture. Levels of type 1 interferon production are cell line-dependent and limited in vitro by lipid-induced cell death. We show that cationic lipids can independently activate TLR-7 and TLR-9, suggesting a mechanism for type 1 interferon induction. This TLR-stimulatory activity is not restricted to R-DOTAP and can be extended to other similar cationic lipids in …

Integrin Α5Β1 As A Novel Target With The Small Peptide, Atn-161, In The Treatment Of Ischemic Stroke, Danielle Nichele Edwards

Theses and Dissertations--Neuroscience

Stroke is the 5^th leading cause of death and the leading cause of disability in the United States, but there are only two available therapies, tissue plasminogen activator and endovascular thrombectomy. As both therapies focus on removal of the clot, the subsequent pathologic processes, i.e. inflammation, cerebrovascular breakdown, ATP depletion, etc. are left untreated, contributing to worsened patient outcome. Many clinical trials have unsuccessfully attempted to address these mechanisms. The blood-brain barrier (BBB), a system of non-fenestrated endothelial cells, extracellular matrix, and astrocytic endfeet, is significantly impacted after ischemic stroke in its role of preventing the free movement of …

The Role Of Cd8 T Cell Immunodominance And Regulatory T Cells In Neonatal Immunity To Influenza Virus, Luke Heil

Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics

Neonates are more susceptible to influenza virus infection than adults, resulting in increased morbidity and mortality as well as delayed clearance of the virus. Efforts to improve influenza infection outcomes in neonates typically center on prevention, although current vaccines fall short of complete protection and can only be administered in humans after 6 months of life. We propose that as the neonatal immune system responds differently than the adult immune system, interventions that are efficacious or tolerable in adults cannot be guaranteed to perform the same in neonates. T cell vaccines that target conserved influenza virus epitopes have been proposed …

Neuroprotective Strategies Following Experimental Traumatic Brain Injury: Lipid Peroxidation-Derived Aldehyde Scavenging And Inhibition Of Mitochondrial Permeability Transition, Jacqueline Renee Kulbe

Theses and Dissertations--Neuroscience

Traumatic brain injury (TBI) represents a significant health crisis. To date there are no FDA-approved pharmacotherapies available to prevent the neurologic deficits caused by TBI. Following TBI, dysfunctional mitochondria generate reactive oxygen and nitrogen species, initiating lipid peroxidation (LP) and the formation of LP-derived neurotoxic aldehydes, which bind mitochondrial proteins, exacerbating dysfunction and opening of the mitochondrial permeability pore (mPTP), resulting in extrusion of mitochondrial sequestered calcium into the cytosol, and initiating a downstream cascade of calpain activation, spectrin degradation, neurodegeneration and neurologic impairment.

As central mediators of the TBI secondary injury cascade, mitochondria and LP-derived neurotoxic aldehydes make promising …

Tgf-Β, Wnt, And Fgf Signaling Pathways During Axolotl Tail Regeneration And Forelimb Bud Development, Qingchao Qiu

Theses and Dissertations--Neuroscience

Tgf-β, Wnt, and Fgf signaling pathways are required for many developmental processes. Here, I investigated the requirement of these signaling pathways during tail regeneration and limb development in the Mexican axolotl (Ambystoma mexicanum).

Using small chemical inhibitors during tail regeneration, I found that the Tgf-β signaling pathway was required from 0-24 and 48-72 hours post tail amputation (hpa), the Wnt signaling pathway was required from 0-120 hpa, and the Fgf signaling pathway was required from 0-12hpa. Tgf-β1 was upregulated after amputation and thus may mediate Tgf-β signaling pathway during tail regeneration. Both Smad-mediated and non-Smad mediated Tgf-β signaling …

Autologous Peripheral Nerve Grafts To The Brain For The Treatment Of Parkinson's Disease, Andrew Welleford

Theses and Dissertations--Neuroscience

Parkinson’s disease (PD) is a disorder of the nervous system that causes problems with movement (motor symptoms) as well as other problems such as mood disorders, cognitive changes, sleep disorders, constipation, pain, and other non-motor symptoms. The severity of PD symptoms worsens over time as the disease progresses, and while there are treatments for the motor and some non-motor symptoms there is no known cure for PD. Thus there is a high demand for therapies to slow the progressive neurodegeneration observed in PD. Two clinical trials at the University of Kentucky College of Medicine (NCT02369003, NCT01833364) are currently underway that …

Consumer Embarrassment – A Meta-Analytic Review And Experimental Examination, Alexander H. Ziegler

Theses and Dissertations--Marketing and Supply Chain

This dissertation consists of two essays that discuss the influence of embarrassment on consumers. In the first essay, I examine consumers’ coping responses to embarrassment in a meta-analytic review. In essay two, I utilize an experimental approach to investigate the impact of embarrassing encounters on unrelated consumers who merely observe the situation.

In the first essay, the meta-analysis is guided by findings in the literature that demonstrate embarrassment can both promote and detract from consumer well-being. However, despite being investigated for decades, little is known about how consumers cope with embarrassing situations, and when and why consumers respond in positive …

Essays On External Forces In Capital Markets, Marcus Painter

Theses and Dissertations--Finance and Quantitative Methods

In the first chapter, I find counties more likely to be affected by climate change pay more in underwriting fees and initial yields to issue long-term municipal bonds compared to counties unlikely to be affected by climate change. This difference disappears when comparing short-term municipal bonds, implying the market prices climate change risks for long-term securities only. Higher issuance costs for climate risk counties are driven by bonds with lower credit ratings. Investor attention is a driving factor, as the difference in issuance costs on bonds issued by climate and non-climate affected counties increases after the release of the 2006 …

Price Discrimination On Complementary Goods: Evidence From The Men's Shaving Razor Market, Zheng Yang

Theses and Dissertations--Economics

This dissertation analyzes the men's razor market to examine whether a monopolist can implement price discrimination for the complementary goods. I estimate a demand system for razors using the random coefficient logit model with market level sales data from the Nielsen Store Scanner dataset and individual demographic data from the March CPS. The estimated parameters are used to construct price-cost markups. By comparing the markups of different products, I find evidence that Gillette uses a two-part tariff strategy. This conclusion can be generalized as that of a monopolist setting the prices of tie-in products consistent with a two-part tariff.

Essays On Child Well-Being And The Social Safety Net, Cody N. Vaughn

Theses and Dissertations--Economics

This dissertation consists of three essays examining the role of two particular social safety net programs, the Temporary Assistance for Needy Families (TANF) program and the Supplemental Nutrition Assistance Program (SNAP), on the well-being of children from disadvantaged households. While the impact of these programs on the adults and parents of the household have been studied extensively, less is known about their effect on children. This is true for both their immediate impact on child well-being and any long-run impacts on children who grow up under these programs. Given the demonstrated importance of child well-being on later life adult outcomes, …

The Impact Of Medicare Part D On Mortality And Financial Stability, Katherine Toran

Theses and Dissertations--Economics

Using the Health and Retirement Study Panel core files from 1996 to 2014, I analyze how Medicare Part D impacted access to prescription drug coverage by various demographic factors such as race, gender, and income. In Chapter 1, I find the highest take-up rates for those who were white, female, and with higher incomes. However, increases in coverage were high across the board, such that Medicare Part D also improved drug insurance coverage for those who were black, male, and with lower income. Thus, although Medicare Part D did increase prescription drug insurance coverage for seniors across the board, I …

Transforms In Sufficient Dimension Reduction And Their Applications In High Dimensional Data, Jiaying Weng

Theses and Dissertations--Statistics

The big data era poses great challenges as well as opportunities for researchers to develop efficient statistical approaches to analyze massive data. Sufficient dimension reduction is such an important tool in modern data analysis and has received extensive attention in both academia and industry.

In this dissertation, we introduce inverse regression estimators using Fourier transforms, which is superior to the existing SDR methods in two folds, (1) it avoids the slicing of the response variable, (2) it can be readily extended to solve the high dimensional data problem. For the ultra-high dimensional problem, we investigate both eigenvalue decomposition and minimum …

Depressive Symptoms Among Farm Women Aged 50 And Older, Cheryl Dean Witt

Theses and Dissertations--Nursing

Alarming rates of suicide among production farmers have prompted researchers to investigate factors associated with depressive symptoms among this population. Aspects of farm life and farming can contribute to higher levels of depressive symptoms. Higher levels of depression can also increase an individual’s risk of injury and development of chronic disease, impacting overall quality of life. Despite the approximate 3.5 million farm women in the U.S., current research has focused on the male farmer.

Men and women have different responses to stressors, and women in general have a higher prevalence of depressive symptoms. Farm women can be further subjected to …

Neurochemical Factors Associated With The Initial Pathophysiological Reaction To Large Vessel Occlusion Stroke, Sarah R. Martha

Theses and Dissertations--Nursing

Ischemic stroke is the leading cause of disability world-wide and affects over 800,000 people per year in the United States. The majority of these strokes are ischemic due to a blockage of blood flow to the brain. Damage to the brain occurs at the onset of stroke, neuronal cell death is irreversible and therefore, quick treatment to remove blockage is critical factor in the recovery from stroke. Mechanical thrombectomy as a treatment for ischemic stroke provides an ideal opportunity to collect blood distal and proximal to the cerebral thrombus to examine neurochemical changes occurring during stroke.

The purpose of this …

End-Of-Life Decision-Making In Patients With A Cardiac Device, Jessica Harman Thompson

Theses and Dissertations--Nursing

Heart failure (HF) is one of the top causes of mortality in the United States and globally. In order to combat the high mortality rates of this disease, medical technology, including internal cardioverter defibrillators (ICD) and left ventricular assist devices (LVAD), have become one of the most common treatments. Over the past 10 years the utilization of these cardiac devices has increased exponentially, which has created a new phenomenon of how we discuss death with patients who have one of these devices. The purpose of this dissertation is to increase understanding of the end-of-life decision making processes and current experiences …

A Lifestyle Intervention To Decrease Risk Of Developing Type 2 Diabetes Mellitus In A Rural Population, Amanda Culp-Roche

Theses and Dissertations--Nursing

Individuals with type 2 diabetes mellitus (T2DM) are at risk for developing life-threatening comorbidities such as cardiovascular disease (CVD). As a consequence, T2DM is associated with increased morbidity and mortality and decreased quality of life, thus highlighting the importance of prevention of T2DM. Further, the prevalence of T2DM is substantially greater in rural populations compared to urban populations, making rural individuals particularly appropriate targets for T2DM prevention.

T2DM is a largely preventable disease that is associated with modifiable risk factors such as poor diet, sedentary lifestyle, and obesity. Lifestyle interventions to improve these modifiable risk factors have been used to …

Race-Based Discrimination, Occupational Stress, And Depression In Black Registered Nurses, Arica A. Brandford

Theses and Dissertations--Nursing

The purpose of this dissertation was to examine depression, experiences of work-related racism, and occupational stress among black nurses. Nursing is a highly stressful and demanding profession that can negatively affect health. Underscoring this is the high rate of depression experienced by nurses. In fact, nurses experience depression at a rate twice that of individuals in other occupations. Examining depression in nurses can provide insights that can inform measures addressing the psychological health of this group. This may be particularly important in black nurses who, in addition to the already high occupational stress associated with nursing, may experience additional stress …

Frailty In Patients Undergoing Left Ventricular Assist Device Implantation, Candice Falls

Theses and Dissertations--Nursing

Heart failure is a progressive condition that affects over 5.7 million Americans and costs associated with heart failure account for 2-3 % of the national health care budget. The high rates of morbidity and mortality along with increased costs from readmissions associated with advanced heart failure have led to the exploration of advanced treatments such as left ventricular assist devices (LVADs). LVADS have demonstrated morbidity and mortality benefit but cost remains extensive with costs per quality-adjusted years > $400,000. With this in mind, it is important to identify those who are most likely to benefit from an LVAD to avoid unfavorable …

Caregivers’ Influence On Patients’ Heart Failure Self-Care, Hospital Readmission And Mortality, Linda Clements

Theses and Dissertations--Nursing

Background: Heart failure (HF) is a leading cause of hospitalization, readmissions, and death in the United States. Patients hospitalized for HF are at risk for readmission, in- hospital mortality, and early post-discharge death. In the United States, inpatient care has been estimated to cost $83,980 over the lifetime of each patient with HF. The majority of patients with HF depend on caregiver support for successful HF self-care, which is essential for optimal patient outcomes. Support from caregivers is thought to be important for better self-care, and lower readmission and mortality rates. Yet, there are few studies considering the influence of …

The Impact Of Maternal Nutrition During Pregnancy On Inflammation And Birth Outcomes, Lori Ogden

Theses and Dissertations--Nursing

More than 85% of American adults do not consume recommended amounts of fruits or vegetables. Preterm birth and hypertensive disorders of pregnancy are common adverse conditions affecting pregnancy and are leading causes of maternal and fetal morbidity and mortality. Preterm birth affects nearly 10% of all births in the United States and is on the rise, as are hypertensive disorders, which have increased by 25% over the last two decades. Pregnancy is a state of controlled inflammation, and dysregulation has been linked to preterm birth and other adverse gestational outcomes. A healthy diet is recommended in pregnancy, but little is …

Gay Men And Satisfaction With Health Care Interactions, Michael Huggins

Theses and Dissertations--Nursing

The purpose of this research was to determine relationships among depression, anxiety, self-rated physical and mental health, self-advocacy, internalized homophobia, and quality of patient-provider communication to satisfaction with health care interactions. These were measured while controlling for select demographic variables: age; ethnicity; urban or rural domicile; relationship status; household income; highest educational attainment; health insurance; disclosure to health care provider as a gay man; reason for last healthcare visit; and, general health self-rating. The specific aims of this study were to: 1) identify general characteristics of gay men in this sample; 2) examine how levels of satisfaction with health care …