Digital Commons Network^™

An Ecological Approach To Understanding Lethal Violence In The Us Using Stream Analogy, Jacqueline Seals

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

ABSTRACT OF CAPSTONE

Background: Lethal violence, homicides and suicides, is a growing issue in the US. Historically homicides and suicides have been studied separately, but with stream analogy of lethal violence homicides and suicides are both currents of lethal violence, just branching in opposite directions. The purpose of this study is to understand which county-level factors increase risk of lethal violence.

Methods: This ecological study combined open-source datasets to create one dataset of socioeconomic risk factors of lethal violence. Counties with 10 or more lethal violent deaths were included (n=2751). Negative Binomial models examined the relationship between risk factors and …

The Role Of Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 9 In Enhanced Aggressiveness Of Hexavalent Chromium Transformed Bronchial Epithelial Cells, Peter Van Wie

Theses and Dissertations--Toxicology and Cancer Biology

Hexavalent chromium (Cr(VI)) is classified as a confirmed human carcinogen by the International Agency for Research and Cancer (IARC) and by the U.S. Environmental Protection Agency (EPA). Chronic exposure to (Cr(VI)) causes malignant cell transformation in human bronchial epithelial BEAS-2B cells. These Cr(VI)-transformed cells exhibit a highly aggressive phenotype including increased migration, invasion, and angiogenesis. The Cas family protein neuronal precursor developmentally down regulated protein 9 (NEDD9/Cas-L/HEF1) was dramatically overexpressed in Cr(VI)-transformed cells compared to normal BEAS-2B cells. Knockdown of NEDD9 by its shRNA reduced migration and invasion in vitro measured by migration and invasion assays. shNEDD9 reduced tumor formation …

Algebraic And Geometric Properties Of Hierarchical Models, Aida Maraj

Theses and Dissertations--Mathematics

In this dissertation filtrations of ideals arising from hierarchical models in statistics related by a group action are are studied. These filtrations lead to ideals in polynomial rings in infinitely many variables, which require innovative tools. Regular languages and finite automata are used to prove and explicitly compute the rationality of some multivariate power series that record important quantitative information about the ideals. Some work regarding Markov bases for non-reducible models is shown, together with advances in the polyhedral geometry of binary hierarchical models.

Mapping The Tutoring Referral Network: Exploring The Student-To-Tutoring Connection, G. Mason Tudor

Theses and Dissertations--Educational Policy Studies and Evaluation

This study explores the institutional network which connected students to a tutoring program at a community college. The study identifies the most likely areas that would refer students to or inform students about the tutoring program. Additionally, the study seeks to understand how different students may have interacted with that network of departments in varied patterns of engagement. While exploring and describing this group of institutional units and their function of connecting students to tutoring, I utilized a multi-phase, mixed methods approach. This methodology began with qualitative information gathering with document analysis, followed by two focus group interviews. I constructed …

Atv Dynamics And Pediatric Rider Safety, James T. Auxier Ii

Theses and Dissertations--Biomedical Engineering

It has been observed through numerous academic and governmental agency studies that pediatric all-terrain vehicle ridership carries significant risk of injury and death. While no doubt valuable to safety, the post-hoc approach employed in these studies does little to explain the why and how behind the risk factors. Furthermore, there has been no prolonged, widespread, organized, and concerted effort to reconstruct and catalog the details and causes of the large (20,000+) number of ATV-related injuries that occur each year as has been done for road-based motor vehicle accidents. This dissertation takes the opposite approach from a meta-analysis and instead examines …

Assessment Of White Matter Hyperintensity, Cerebral Blood Flow, And Cerebral Oxygenation In Older Subjects Stratified By Cerebrovascular Risk, Ahmed A. Bahrani

Theses and Dissertations--Biomedical Engineering

Objective: Cerebrovascular disease (CVD) is the fifth most common cause of mortality in the United States. Diagnosis of CVD at an early stage is critical for optimal intervention designed to prevent ongoing and future brain injury. CVD is commonly associated with abnormalities of the cerebral microvasculature leading to tissue dysfunction, neuronal injury and death, and resultant clinical symptoms, which in turn, further impacts cerebral autoregulation (CA). This series of studies aims to test the hypothesis that white matter hyperintensities (WMH) and cerebral hemodynamics (quantified by magnetic resonance imaging (MRI) and an by innovative hybrid near-infrared diffuse optical instrument) can be …

Work Related Diurnal Changes In Trunk Mechanical Behavior, Maeve Mcdonald

Theses and Dissertations--Biomedical Engineering

The objectives of this study were to analyze effects of day-long exposure to LBP risk factors on lumbo-pelvic coordination (LPC) in nursing occupations and to verify if physical activity level affects diurnal work-related changes in LPC. Thirty-three nurses were recruited into three groups based on workplace physical demands and each completed two data collection sessions, one before and one after their 8-12 hour work shift. Participants completed several stationary trunk forward-bending/backward-return exercises at self-selected “fast” and “slow” rotational speeds, and while holding a 15 lbs. load. Kinematic data collected during these exercises were then used to characterize the timing and …

Noncontact Multiscale Diffuse Optical Imaging Of Deep Tissue Hemodynamics In Animals And Humans, Siavash Mazdeyasna

Theses and Dissertations--Biomedical Engineering

Blood flow (BF) impacts the delivery of oxygen and nutrients to tissues and the removal of metabolic byproducts from tissues. Imaging of BF distributions helps characterize many diseases associated with tissue hypoxia/ischemia. The purpose of this study was to develop and validate a novel, noninvasive, noncontact, high-density camera-based speckle contrast diffuse correlation tomography (scDCT) device for use in both animal and human studies. The scDCT uses a galvo-mirror to remotely deliver the focused point near-infrared light to source positions and a sensitive 2D camera to quantify spatial diffuse speckle fluctuations, resulting from the movement of red blood cells in deep …

A Modeling Approach To Understanding Glyphosate Transport In The Belize River Watershed, Barbara Anmei Astmann

Theses and Dissertations--Civil Engineering

Glyphosate is the most widely used herbicide worldwide and is often transported from application areas to surface water when solubilized in runoff or sorbed to eroded sediment. There is evidence that suggests both glyphosate and its main metabolite aminomethylphosphonic acid (AMPA) may pose a risk to human health, as well as cause adverse effects in the environment. However, consistent monitoring data is still limited, especially in developing countries. Belize is a developing nation with agriculture being a major sector of its economy and is heavily reliant on glyphosate. The widespread use of glyphosate in Belize may be resulting in glyphosate …

Investigation Into The Presence, Persistence, And Fate Of S. Aureus, And Its Mobile Genetic Elements, In Wastewater And The Surrounding Environment, Atena Amirsoleimani

Theses and Dissertations--Civil Engineering

Currently, the world is engaged in a battle against very small parts of our environment that develop and share genes for resistance to multiple environmental conditions. Pathogenic infections caused by antibiotic-resistant bacteria have been impacting animal and human health and life. Increasing incidences of methicillin- resistant Staphylococcus aureus (MRSA) infections transmitted through the environment are rising faster than the discovery of new antibiotics. Multi-drug resistant S. aureus infections in healthy individuals without prior hospitalization have been increasing all around the world.

Many people carry S. aureus in their nose and on their skin, common niches for the bacteria to co-grow …

Reliability Assessment And Optimization Of Water Distribution Systems Explicitly Considering Isolation Valve Locations, Erika Hernandez Hernandez

Theses and Dissertations--Civil Engineering

Water distribution systems have changed the landscape of communities through two services: 1) providing water supply for domestic and industrial use, and 2) providing water required to fight fires. However, a substantial portion of the water infrastructure in the country, as many of other public assets built over 50 years ago, are now reaching the end of their useful life; which combined with rapid growth and changes in demographics have placed water distribution pipe networks at a state that requires revitalization. The aging infrastructure along with the growing threat of natural and man-made disruptions have led water utilities to place …

Text Mining Methods For Analyzing Online Health Information And Communication, Sifei Han

Theses and Dissertations--Computer Science

The Internet provides an alternative way to share health information. Specifically, social network systems such as Twitter, Facebook, Reddit, and disease specific online support forums are increasingly being used to share information on health related topics. This could be in the form of personal health information disclosure to seek suggestions or answering other patients' questions based on their history. This social media uptake gives a new angle to improve the current health communication landscape with consumer generated content from social platforms. With these online modes of communication, health providers can offer more immediate support to the people seeking advice. Non-profit …

Fabrication, Characterization And Applications Of Highly Conductive Wet-Spun Pedot:Pss Fibers, Ruben Sarabia Riquelme

Theses and Dissertations--Chemical and Materials Engineering

Smart electronic textiles cross conventional uses to include functionalities such as light emission, health monitoring, climate control, sensing, storage and conversion of energy, etc. New fibers and yarns that are electrically conductive and mechanically robust are needed as fundamental building blocks for these next generation textiles.

Conjugated polymers are promising candidates in the field of electronic textiles because they are made of earth-abundant, inexpensive elements, have good mechanical properties and flexibility, and can be processed using low-cost large-scale solution processing methods. Currently, the main method to fabricate electrically conductive fibers or yarns from conjugated polymers is the deposition of the …

Landscape Ecology And Population Genomics Of Two Sympatric Pitviper Species Across A Fragmented Appalachian Landscape, Thomas Maigret

Theses and Dissertations--Biology

Understanding the link between landscape patterns and ecological and evolutionary processes is an important prerequisite for informed wildlife conservation and management, especially in rapidly changing landscapes. Until recently, the inaccessibility of spatial and genomic data sets of sufficient resolution limited our ability to incorporate the impacts of landscape patterns into predictions of ecological and environmental outcomes. In this dissertation, I utilized several high-resolution spatial and genomic data sets to address ecological questions in a rapidly fragmenting landscape in southeastern Kentucky. Overall, my results indicate that large-scale surface coal mining is causing widespread homogenization of landforms, resulting in a uniquely permanent …

The Role Of Melatonin In Biological Rhythms Of Songbirds, Clifford E. Harpole

Theses and Dissertations--Biology

In vertebrates, melatonin is a hormone that is produced and secreted at night and inhibited by light. This unique “darkness-only” expression profile makes it an intellectually appealing candidate for a means of transmitting temporal information to an individual, both time of day and time of year.

In passerine birds, “time of day” information is certainly transmitted via melatonin secretion. The primary producer of systemic melatonin in this family of birds is the pineal gland, and surgical removal of it causes a bird to become arrhythmic in constant conditions. I find that as pinealectomized house sparrows (Passer domesticus) become …

Investigation Into The Roles Of Her9 And Capn5 During Retinal Development And Regeneration, Cagney Coomer

Theses and Dissertations--Biology

The formation of a healthy and functioning eye requires coordinated interactions between numerous signaling pathways and gene regulatory networks within the developing neural retina. Tight regulation of gene expression is required for cell specification and differentiation in this multilayered, light sensitive tissue. The photoreceptors are the light detecting cells of the retina, capable of functioning in both intense sunlight and dim light at night. When pigment cells of the photoreceptor outer segment are activated by light, a complex chain of events called phototransduction leads to the electrical signal cascade that is transmitted through the retina and ultimately to the brain …

A Multi-Method Investigation Of The Modern Sedimentation And Late Holocene Paleolimnology Of June Lake (Mono County, Ca), And A Survey-Based Analysis Of Ninth Graders’ Attitudes Towards Geology, Eva Lyon

Theses and Dissertations--Earth and Environmental Sciences

Three distinct manuscripts comprise this dissertation. The first analyzes the modern sedimentary basin of June Lake, a small glacial lake in the eastern Sierra Nevada of California (USA) using a number of data sets, including bathymetry, surface sediment composition, and seismic stratigraphy. The seismic survey revealed sublacustrine morphological features that suggest the basin originated due to ice scour, as well as four acoustically distinct stratigraphic units that reflect the history of sedimentation following glacial scouring. Corroborating the seismic record, sediment cores from the youngest unit are composed of hemipelagically deposited, organic-rich, laminated diatomaceous oozes alternating with coarse tephra beds. The …

Identification Of The Causes And Extent Of Elevated Methane Concentrations In The Groundwater Of Eastern Kentucky, Cristopher Alvarez Villa

Theses and Dissertations--Earth and Environmental Sciences

Recent development of unconventional oil and gas (UOG) resources has prompted concerns about its potential impact on public health and the quality of water and air resources. Elevated dissolved methane concentrations (> 1 mg/L) have been associated with proximity to UOG development and stray gas, but also with natural microbial activity. Baseline gas data, local hydrogeology and geochemistry context can aid assessment of methane sources and interactions. Methane concentrations in eastern Kentucky groundwater are above the “immediate action” level in some private/domestic water wells, show wide variations over small distances, and have been hypothesized to have different relationships to mining. …

Risky Business: Visualizing And Historicizing The Role Of Geographic Representation And Thinking In American Business, John Swab

Theses and Dissertations--Geography

Geographic representation and thinking has a long history in the American business world. This thesis examines the role of geographic representation and thinking in the fire insurance industry in the late nineteenth and early twentieth centuries through the Sanborn Map Company and in the development of site selection as a concept in the mid-twentieth century through the biography of William Applebaum. Through these case studies, I explore the relevance applied cartographic representations to the business world and the opportunities it presents towards advancing geography as a discipline.

Freakish Taxonomies: How The American Freak Show And Its Literature Redefine The Archive, Megan E. Pillow

Theses and Dissertations--English

The American freak show, which dominated the entertainment landscape from 1840 to 1940, is considered by some disability studies scholars to be off limits for critical engagement. In Freakish Taxonomies: How the American Freak Show and its Literature Redefine the Archive, I argue that by casting the freak show solely as an exploitative institution, we overlook its capacity to serve as a model for reinterpreting the relationship between literary studies and the archive. By recognizing the freak show not just as an exploitative institution but also as a dynamic archive of marginalized lives—one that utilizes an imperfect, often deceptive …

Relevant Angry Affect Slows Response Time To Commands, Aleah Combs

Theses and Dissertations--Linguistics

Previous research has found that emotional prosody can interact with speech perception and listeners’ processing of the meaning of particular word/emotion pairings(Kim and Sumner, 2017). What remains unclear is how this interactive processing can affect behavioral responses such as responses to imperatives. To answer this question,71 participants were presented with a series of commands given in a relevant affect.Commands were read either with angry prosody, happy prosody, or neutral prosody (control) and the participants were instructed to press the requested button on a response box as quickly and accurately as possible. All emotional states were simulated and normed for perceived …

An Intonational Description Of African American Language In Princeville, Nc, Christopher M. Dale

Theses and Dissertations--Linguistics

This thesis uses data from the Princeville, NC section of the Corpus of Regional African American Language (CORAAL) in order to address two topics concerning language: first, what the intonation of the Princeville participants of the CORAAL looks like acoustically; and second, if intonation is the salient feature that categorizes a speaker as Black or non-Black. The acoustic analysis software, Praat (Boersma & Weenink 2019), is used to take average, minimum, and maximum f0 measurements for 16 participants (9 women and 7 men) across three age groups. From these measurements, the rate of change is calculated in Hz/second to determine …

The Mothman And Other Strange Tales: Shaping Queer Appalachia Through Folkloric Discourse In Online Social Media Communities, Brenton Watts

Theses and Dissertations--Linguistics

Little work has been conducted on the intersections of queer and Appalachian identities, in part because these two identities are viewed as incompatible (Mann 2016). This study uses a multimodal critical discourse analytic approach to examine the Instagram posts of the Queer Appalachia Project, which represent a substantial body of discourse created by and for queer Appalachians. Of specific interest to this analysis are those posts which employ folkloric figures, such as West Virginia’s Mothman, to do identity work that is queer, Appalachian, and queer-Appalachian. Often, this act is accomplished through juxtaposition with Appalachian imagery and the reclamation of homophobic …

“Home Is More Than Just A Place”: Oral Personal Narrative Storytelling In Central Appalachia, Brandon Jent

Theses and Dissertations--Linguistics

This project seeks a linguistic understanding of oral personal narrative storytelling in Central Appalachia, particularly as it manifests in Eastern Kentucky, with aims of providing insight into the Appalachian storyteller trope (e.g., Montgomery 1998). Structural and discursive elements of oral personal narrative were identified and positioned within their sociocultural context through discourse analysis and narrative studies. Data were collected from story circles, a methodology first implemented in cultural and community organizing spaces in the South and throughout Appalachia (Roadside Theater 2014, Junebug Productions n.d.). The collected stories were transcribed and analyzed through a discourse analysis framework that combines discourse pragmatics, …

El Bildungsroman Femenino Mexicano: Nuevas Perspectivas De La Novela De Formación Femenina Fronteriza, Yorki Junior Encalada Egúsquiza

Theses and Dissertations--Hispanic Studies

The late 20^th and early 21^st centuries have not only favored a steady growth in Chicana literary production but have also revealed an alternative identity of the Mexican American border woman, the meXicana. Rosa Linda Fregoso, in MeXicana Encounters (2003), coins and defines this term as “the interface between Mexicana and Chicana,” and employs it to examine the experiences and representations of Mexicanas and Chicanas without eliminating the differences between them. This study borrows this term but uses it specifically to describe North American women of Mexican origin whose identities and border-crossing experiences make it difficult to solely …

The Coulter Principle: For The Good Of Humankind, Marshall Graham

Theses and Dissertations--History

The atomic bombings of Hiroshima and Nagasaki in August 1945 made Wallace H. Coulter abruptly comprehend the critical need for rapid and accurate blood-cell counts in providing care for victims of radiation exposure. This thesis documents the unwritten story of his journey from that comprehension through his invention and implementation of the Coulter Principle, its commercialization in the first widely available automated blood-cell counter, and elaboration of that ground-breaking counter into increasingly sophisticated instrumentation for analysis not only of blood cells, but of particles involved in many other scientific disciplines. International cold-war politics and the burgeoning of increasingly powerful nuclear …

Envisioning Catholicism: Popular Practice Of A Traditional Faith In The Post-Wwii Us, Christy A. Bohl

Theses and Dissertations--History

Marian apparitions in the United States have occurred in ever-increasing numbers since World War Two, particularly in the 1980s and 1990s. These apparitions occupy a unique space in religious life, as they provide opportunities for Catholics to practice their faith outside of the Church hierarchy while still maintaining their status as faithful Catholics, often placing women in prominent positions. Although apparitions are an important part of faith for thousands of American Catholics, most Americans and Catholics are unaware of how widespread this movement is. This dissertation takes a comparative approach to examine a selection of apparition events, illuminating the pilgrimage …

Voices “Herd”: A Social And Sentiment Analysis Of Consumers Perceptions Of Fair Oaks Farms, Jacelyn De'nae Nesmith

Theses and Dissertations--Community & Leadership Development

Americans are searching for more information than just cost and quality of their food. Today, consumers are searching for information regarding the production practices and how animals are treated during the process. As consumers do not always have a first-hand source for this information, they are often referring to social media to have their questions answered. Social media has the reputation to negatively influence public perceptions of the agricultural industry. An example of an organization experiencing the consequences of social media influencing public opinion is Fair Oaks Farms. In 2019, an undercover animal rights activist group made accusations of poor …

An Examination Of Single-Sex Secondary Agricultural Education Classrooms: The Effects Of Teacher Expectancy, Brett Morris Wasden

Theses and Dissertations--Community & Leadership Development

The effectiveness of single-sex classrooms in the United States remains unclear. To address this issue, the purpose of this quasi-experiment was to examine single-sex classrooms in secondary agricultural education classrooms in Kentucky. Data were collected through quantitative pretests and posttests from student participants (n = 168) and teacher participants (n = 8). The findings indicated that student participants in single-sex classrooms had higher academic performance, better attendance, and an increased gain in interest in the agriculture, food, and natural resources career pathway. Students participants in coeducational classrooms had less discipline referrals. Teacher participants’ expectation were related to student …

Women Returning To Their Families And Communities After Incarceration: Their Needs, Concerns And Challenges, Julius Johnson

Theses and Dissertations--Community & Leadership Development

The voices of women in re-entry from prison have been muted for many decades. Prior research conducted on men and prison re-entry has been used to shape not only prisons but also the reentry process for women. It is because of this oversight that the gender-specific needs of women in the justice system have gone unnoticed. Once released, formerly incarcerated women face the almost impossible task of finding employment. Many women who find employment have found that their wages do not help them move out of poverty. Trying to find adequate housing becomes an issue not only because of their …