Digital Commons Network^™

Policy Storms At The Central Office: Conflicting Narratives Of Racial Equity And Segregation At School Committee Meetings, Serena M. Wilcox

Educational Policy Studies and Evaluation Faculty Publications

This article reports findings from a multiyear critical ethnography that examined race talk dilemmas of school leaders at the central office at a small urban school district to understand why racialized educational policies and practices still persist against African American students. This study takes a structural approach to investigating the impact that race talk has on educational policymaking at the local district level. The guiding research question in this paper examines how we can understand educational reform and policy implementation and the unintended consequences of those interventions through the local from a historical context.

Forage News [2020-06], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

No abstract provided.

Effect Of Socioeconomic Factors On Kentucky Truck Driver Crashes, Nikiforos Stamatiadis, Shraddha Sagar, Samantha Wright, Aaron Berry Cambron

Kentucky Transportation Center Research Report

Kentucky crash data for the 2015-2016 period reveal that per capita crash rates and increases in crash-related fatalities in the state outpaced the national average. To explain why the U.S. Southeast sees higher crash rates than other regions of the country, previous research has argued the region’s unique socioeconomic conditions provide a compelling explanation. Taking this observation as a starting point, this study uses an extensive crash dataset from Kentucky to examine the relationship between highway safety and socioeconomic and demographic characteristics. Its focus is single- and two-unit crashes that involve commercial motor vehicles (CMVs) and automobiles. Using binary logistic …

Rural/Urban Disparities In Utilization Of Diabetes Self-Management Training To The Fee-For-Service Medicare Population, Christian Rhudy, Aric Schadler, Jeffery C. Talbert

Rural & Underserved Health Research Center Publications

Overview of Key Findings

• In 2016, rural fee-for-service (FFS) Medicare beneficiaries represented 21.7% of the population diagnosed with diabetes, but only 2.7% of the population utilizing Diabetes Self-Management Training.
• Utilization of DSMT services in 2016 occurred in 76 rural counties and 309 urban counties.
• Average utilization rates of DSMT services were greater in rural counties than urban counties (5.5% vs. 2.5%).

Rural/Urban Disparities In The Utilization Of Health And Behavioral Assessments/Interventions In The Fee-For-Service Medicare Population, Christian Rhudy, Eugene Shin, Jeffery C. Talbert

Rural & Underserved Health Research Center Publications

Overview of Key Findings

• In 2016, rural county residents represented 21.8% of the fee-for-service (FFS) Medicare population, but only 1.6% of rural FFS beneficiaries live in a county with local utilization of Health and Behavioral Assessments and Interventions (HBAI) services.
• Utilization of HBAI services in 2016 occurred in 19 (9.7%) rural counties and 176 (90.3%) urban counties.
• Average utilization rates of HBAI services were higher in rural counties than urban counties (0.7% vs. 0.4%).

Rural/Urban Disparities In Utilization Of Medical Nutrition Therapy To The Fee-For-Service Medicare Population, Christian Rhudy, Eugene Shin, Jeffery C. Talbert

Rural & Underserved Health Research Center Publications

Overview of Key Findings

• In 2016, 21.8% of the fee-for-service (FFS) Medicare population resided in a rural county, but only 3.7% of enrollees residing in a county with utilization of Medical Nutrition Therapy (MNT) services were rural county residents.
• Utilization of MNT services in 2016 occurred in 92 rural counties and 388 urban counties.
• Average utilization rates of MNT services were greater in rural counties than urban counties (3.1% vs. 1.9%).

Major Depression, Treatment Receipt, And Treatment Sources Among Non-Metropolitan And Metropolitan Adults, Tyrone F. Borders

Rural & Underserved Health Research Center Publications

Overview of Key Findings

• 7.8% of non-metropolitan (weighted number of persons=2,755,020) and 7.1% of metropolitan (weighted number of persons=14,868,655) adults had past year major depression.
• Treatment receipt (seeing a health professional or using prescription medication for depressive feelings) was similar among non-metropolitan (68.0%) and metropolitan (64.6%) adults.
• A closer examination of the type and source of treatment revealed the following:

• Rates of seeing a health professional were similar among non-metropolitan (60.8%) and metropolitan (58.4%) adults, but rates of using prescription medication for depressive feelings were higher among non-metropolitan (58.2%) than metropolitan (48.6%) adults.
• Rates of visiting a general practice/family doctor …

Potential Effect Of Cable Median Barriers On Commercial Vehicle Crossover Crashes, Nikiforos Stamatiadis, Shraddha Sagar, Samantha Wright, Eric R. Green, Reginald R. Souleyrette, Michael A. Fields, Teng Alex Wang

Kentucky Transportation Center Research Report

In 2016, commercial motor vehicles (CMVs) were involved in 4,079 fatal crashes in the U.S., representing 11.8 percent of all fatal crashes. State of Kentucky crash data for 2015-2016 show that per capita crash rates and increases in crash-related fatalities exceeded the national average. Crossover crashes occur when a vehicle leaves its intended path and veers into the path of oncoming traffic, typically resulting in head-on or sideswipe opposite direction crashes. Cable median barriers are a countermeasure which can potentially be used to mitigate crossover crashes. This research investigated the potential effectiveness of cable median barriers on CMV crashes. Analysis …

Kytc Maintenance Field Operations Guide Supplement, Bryan Gibson, Candice Y. Wallace, Nancy Albright, Christopher W. Van Dyke, Steven Douglas Kreis

Kentucky Transportation Center Research Report

The Kentucky Transportation Cabinet (KYTC) is tasked with managing an asset portfolio that includes over 27,500 miles of roadway and 9,000 bridges. Keeping these assets in sound condition demands significant effort from KYTC’s Division of Maintenance, which includes activities ranging from mowing and litter pickup to cleaning out culverts and performing emergency roadway work. Despite the immense responsibilities shouldered by Maintenance personnel, until this project the Cabinet’s 12 districts lacked a systematic method for capturing and recording maintenance activities. Through a series of workshops held in each KYTC’s district with Section Engineer and Maintenance Supervisors, researchers at the Kentucky Transportation …

Axillary Artery Pseudoaneurysm Following Percutaneous Transaxillary Access For Impella Device Placement During Percutaneous Coronary Intervention, Anas A. Alharbi, Fahad S. Alqahtani, Peter Farjo, Jason A. Moreland

Internal Medicine Faculty Publications

Percutaneous transaxillary access is currently considered an acceptable alternative to transfemoral approach for large-bore access, especially in the setting of hostile iliofemoral arteries. Few published reports exist concerning complications of upper extremity access. We describe development of an axillary artery pseudoaneurysm and its management following transaxillary access. (Level of Difficulty: Advanced.)

Postnatal Loss Of The Insulin Receptor In Osteoprogenitor Cells Does Not Impart A Metabolic Phenotype, John L. Fowlkes, R. Clay Bunn, Evangelia Kalaitzoglou, Phil Ray, Iuliana Popescu, Kathryn M. Thrailkill

Barnstable Brown Diabetes Center Faculty Publications

The relationship between osteoblast-specific insulin signaling, osteocalcin activation and gluco-metabolic homeostasis has proven to be complex and potentially inconsistent across animal-model systems and in humans. Moreover, the impact of postnatally acquired, osteoblast-specific insulin deficiency on the pancreas-to-skeleton-to-pancreas circuit has not been studied. To explore this relationship, we created a model of postnatal elimination of insulin signaling in osteoprogenitors. Osteoprogenitor-selective ablation of the insulin receptor was induced after ~10 weeks of age in IR^l°^x/lox/Osx-Cre^+/− genotypic male and female mice (designated postnatal-OIRKO). At ~21 weeks of age, mice were then phenotypically and metabolically characterized. Postnatal-OIRKO mice demonstrated …

Examination Of Curcumin And Fenugreek Soluble Fiber Supplementation On Submaximal And Maximal Aerobic Performance Indices, Jensen Goh, Walter Menke, Lauren P. Herrick, Marilyn S. Campbell, Mark G. Abel, Bradley S. Fleenor, Haley C. Bergstrom

Kinesiology and Health Promotion Faculty Publications

This study examined the effects of curcumin and fenugreek soluble fiber supplementation on the ventilatory threshold (VT) and peak oxygen consumption (VO₂ peak). Methods: Forty-five untrained men and women were randomly assigned to one of three supplementation groups: placebo (PLA, n = 13), 500 mg·day⁻¹ CurQfen^® (CUR, n = 14), or 300 mg·day⁻¹ fenugreek soluble fiber (FEN, n = 18). Participants completed a maximal graded exercise test on a cycle ergometer to determine the VT and VO₂ peak before (PRE) and after (POST) 28 days of daily supplementation. Separate, one-way analyses of covariance (ANCOVAs) were …

A Web-Based, Positive Emotion Skills Intervention For Enhancing Posttreatment Psychological Well-Being In Young Adult Cancer Survivors (Empower): Protocol For A Single-Arm Feasibility Trial, John M. Salsman, Laurie E. Mclouth, Michael Cohn, Janet A. Tooze, Mia Sorkin, Judith T. Moskowitz

Behavioral Science Faculty Publications

BACKGROUND: Adolescent and young adult cancer survivors (AYAs) experience clinically significant distress and have limited access to supportive care services. Interventions to enhance psychological well-being have improved positive affect and reduced depression in clinical and healthy populations but have not been routinely tested in AYAs.

OBJECTIVE: The aim of this protocol is to (1) test the feasibility and acceptability of a Web-based positive emotion skills intervention for posttreatment AYAs called Enhancing Management of Psychological Outcomes With Emotion Regulation (EMPOWER) and (2) examine proof of concept for reducing psychological distress and enhancing psychological well-being.

METHODS: The intervention development and testing are …

Longitudinal Evaluation Of The Effects Of Illness Perceptions And Beliefs About Cardiac Rehabilitation On Quality Of Life Of Patients With Coronary Artery Disease And Their Caregivers, Patricia Thomson, Neil J. Angus, Federico Andreis, Gordon F. Rushworth, Andrea R. Mohan, Misook L. Chung, Stephen J. Leslie

Nursing Faculty Publications

Background

Patients’ negative illness perceptions and beliefs about cardiac rehabilitation (CR) can influence uptake and adherence to CR. Little is known about the interpartner influence of these antecedent variables on quality of life of patients with coronary artery disease (CAD) and their family caregivers. The aims of the study were: 1) to assess differences in illness perceptions, beliefs about CR and quality of life between patients with CAD and their family caregivers upon entry to a CR programme and at 6 months follow-up; and 2) to examine whether patients’ and caregivers’ perceptions of the patient’s illness and beliefs about CR …

Isotopes As Natural Recorders Of Grassland Ecosystem Functioning And Change, Hans Schnyder, Karl Auerswald

IGC Proceedings (1977-2023)

No abstract provided.

Rangeland Ecology And Management In A Changing World, Joel R. Brown, Brandon T. Bestelmeyer, Kris M. Havstad

IGC Proceedings (1977-2023)

No abstract provided.

Regulation Of Myofilament Contractile Function In Human Donor And Failing Hearts, Kerry S. Mcdonald, Laurin M. Hanft, Joel C. Robinett, Maya Guglin, Kenneth S. Campbell

Internal Medicine Faculty Publications

Heart failure (HF) often includes changes in myocardial contractile function. This study addressed the myofibrillar basis for contractile dysfunction in failing human myocardium. Regulation of contractile properties was measured in cardiac myocyte preparations isolated from frozen, left ventricular mid-wall biopsies of donor (n = 7) and failing human hearts (n = 8). Permeabilized cardiac myocyte preparations were attached between a force transducer and a position motor, and both the Ca²⁺ dependence and sarcomere length (SL) dependence of force, rate of force, loaded shortening, and power output were measured at 15 ± 1°C. The myocyte preparation size was …

Public Demands On Intensive Grassland Systems And Agri-Environmental Policies Of Oecd Members, Alain Peeters

IGC Proceedings (1977-2023)

No abstract provided.

Livestock Production And Poverty Alleviation--Challenges And Opportunities In Arid And Semi‐Arid Tropical Rangeland Based Systems, C. Seré, A. Ayantunde, A. Duncan, A. Freeman, M. Herrero, Shirley A. Tarawali, I. Wright

IGC Proceedings (1977-2023)

No abstract provided.

Sustainability And Optimization Of Rangeland Uses: Issues Of Perspective And Scale, T. L. Thurow

IGC Proceedings (1977-2023)

No abstract provided.

Overview Of Grassland And Its Development In China, Jiawen Liu, Yingjun Zhang, Yongjun Li, Deli Wang, Guodong Han, Fujiang Hou

IGC Proceedings (1977-2023)

No abstract provided.

21st International Grassland Congress / 8th International Rangeland Congress: Foreward And Acknowledgement, Organizing Committee Of 2008 Igc/Irc Conference

IGC Proceedings (1977-2023)

No abstract provided.

Anti-Aggregation Effects Of Phenolic Compounds On Α-Synuclein, Kenjiro Ono, Mayumi Tsuji, Tritia R. Yamasaki, Giulio M. Pasinetti

Neurology Faculty Publications

The aggregation and deposition of α-synuclein (αS) are major pathologic features of Parkinson's disease, dementia with Lewy bodies, and other α-synucleinopathies. The propagation of αS pathology in the brain plays a key role in the onset and progression of clinical phenotypes. Thus, there is increasing interest in developing strategies that attenuate αS aggregation and propagation. Based on cumulative evidence that αS oligomers are neurotoxic and critical species in the pathogenesis of α-synucleinopathies, we and other groups reported that phenolic compounds inhibit αS aggregation including oligomerization, thereby ameliorating αS oligomer-induced cellular and synaptic toxicities. Heterogeneity in gut microbiota may influence the …

Phyto-Ruminal-Bioremediation: Grasses To The Rescue, Morrie Craig, Jennifer Duringer, Linda Blythe

IGC Proceedings (1977-2023)

The US EPA has defined Super Fund sites for 594 toxins in the United States. The EPA definition of toxins is one that causes acute or chronic human health effects, or causing significant environmental harm. One of the categories of toxins is nitroaromatic molecules, which are used primarily as munitions. In the United States alone there are 16,000 Department of Defense (DoD) sites. The most common munitions there are TNT, RDX, HMX, and 2,4 DNT. In the world, these sites range historically from World War II residues to those from recent Middle East conflicts. Human health effects from these toxins …

Microrna-148a Regulates Low-Density Lipoprotein Metabolism By Repressing The (Pro)Renin Receptor, Na Wang, Lishu He, Hui Lin, Lunbo Tan, Yuan Sun, Xiaoying Zhang, A. H. Jan Danser, Hong S. Lu, Yongcheng He, Xifeng Lu

Saha Cardiovascular Research Center Faculty Publications

High plasma LDL cholesterol (LDL-c) concentration is a major risk factor for atherosclerosis. Hepatic LDL receptor (LDLR) regulates LDL metabolism, and thereby plasma LDL-c concentration. Recently, we have identified the (pro)renin receptor [(P)RR] as a novel regulator of LDL metabolism, which regulates LDLR degradation and hence its protein abundance and activity. In silico analysis suggests that the (P)RR is a target of miR-148a. In this study we determined whether miR-148a could regulate LDL metabolism by regulating (P)RR expression in HepG2 and Huh7 cells. We found that miR-148a suppressed (P)RR expression by binding to the 3’-untranslated regions (3’-UTR) of the (P)RR …

Ccl2 Overexpression In The Brain Promotes Glial Activation And Accelerates Tau Pathology In A Mouse Model Of Tauopathy, Aurelie Joly-Amado, Jordan Hunter, Zainuddin Quadri, Frank Zamudio, Patricia V. Rocha-Rangel, Deanna Chan, Anisha Kesarwani, Kevin Nash, Daniel C. Lee, Dave Morgan, Marcia N. Gordon, Maj-Linda B. Selenica

Sanders-Brown Center on Aging Faculty Publications

Innate immune activation is a major contributor to Alzheimer’s Disease (AD) pathophysiology, although the mechanisms involved are poorly understood. Chemokine C-C motif ligand (CCL) 2 is produced by neurons and glial cells and is upregulated in the AD brain. Transgene expression of CCL2 in mouse models of amyloidosis produces microglia-induced amyloid β oligomerization, a strong indication of the role of these activation pathways in the amyloidogenic processes of AD. We have previously shown that CCL2 polarizes microglia in wild type mice. However, how CCL2 signaling contributes to tau pathogenesis remains unknown. To address this question, CCL2 was delivered via recombinant …

Brain Structure Changes Over Time In Normal And Mildly Impaired Aged Persons, Charles D. Smith, Linda J. Van Eldik, Gregory A. Jicha, Frederick A. Schmitt, Peter T. Nelson, Erin L. Abner, Richard J. Kryscio, Richard R. Murphy, Anders H. Andersen

Neurology Faculty Publications

Structural brain changes in aging are known to occur even in the absence of dementia, but the magnitudes and regions involved vary between studies. To further characterize these changes, we analyzed paired MRI images acquired with identical protocols and scanner over a median 5.8-year interval. The normal study group comprised 78 elders (25M 53F, baseline age range 70-78 years) who underwent an annual standardized expert assessment of cognition and health and who maintained normal cognition for the duration of the study. We found a longitudinal grey matter (GM) loss rate of 2.56 ± 0.07 ml/year (0.20 ± 0.04%/year) and a …

Correlations Of Calf Muscle Macrophage Content With Muscle Properties And Walking Performance In Peripheral Artery Disease, Kate Kosmac, Marta Gonzalez-Freire, Mary M. Mcdermott, Sarah H. White, R. Grace Walton, Robert L. Sufit, Lu Tian, Lingyu Li, Melina R. Kibbe, Michael H Criqui, Jack M. Guralnik, Tamar S. Polonsky, Christiaan Leeuwenburgh, Luigi Ferrucci, Charlotte A. Peterson

Physical Therapy Faculty Publications

Background

Peripheral artery disease (PAD) is a manifestation of atherosclerosis characterized by reduced blood flow to the lower extremities and mobility loss. Preliminary evidence suggests PAD damages skeletal muscle, resulting in muscle impairments that contribute to functional decline. We sought to determine whether PAD is associated with an altered macrophage profile in gastrocnemius muscles and whether muscle macrophage populations are associated with impaired muscle phenotype and walking performance in patients with PAD.

Methods and Results

Macrophages, satellite cells, and extracellular matrix in gastrocnemius muscles from 25 patients with PAD and 7 patients without PAD were quantified using immunohistochemistry. Among patients …

Uremia Preventing Osmotic Demyelination Syndrome Despite Rapid Hyponatremia Correction, Srinadh Annangi, Snigdha Nutalapati, Srikanth Naramala, Pradeep Yarra, Khalid Bashir

Internal Medicine Faculty Publications

Hyponatremia is the most common electrolyte abnormality encountered both in the inpatient and outpatient clinical settings in the United States. Rapid correction leads to a deranged cerebral osmotic gradient causing osmotic demyelination syndrome. Coexisting azotemia is considered to be protective against osmotic demyelination syndrome owing to its counteractive effect on osmolarity change that occurs with rapid hyponatremia correction. In this article, we report the case of a 37-year-old male who presented with altered mentation, acute azotemia, and severe electrolyte derangements, with serum blood urea nitrogen 160 mg/dL, creatinine 8.4 mg/dL, sodium 107 mEq/L, potassium 6.1 mEq/L, bicarbonate 7 mEq/L, and …

Nutrient Profiling And Identification Of Genetic Marker For Azolla Sp., Upendra Kumar, Anjani Kumar, N. Umakanta, T. B. Bagchi, Sangita Mohanty, Awadhesh Kumar, Md Shahid, A. K. Nayak

IGC Proceedings (1977-2023)

Azolla (mosquito fern, duckweed fern, fairy moss and water fern) is a genus of seven species of aquatic ferns. They float on the surface of water by means of scale-like leaves, with their roots hanging in the water. Azolla is able to fix unlinked nitrogen (N₂) directly from the atmosphere because of its endosymbiotic blue alga Anabaena azollae (Van Hove, 1989), and is thus a very promising supply of nitrogen to aquatic ecosystems. In recent years, apart of traditional cultivation of Azolla as a bio-fertilizer for wetland paddy, also find increasing use for sustainable production of livestock feed. …