Digital Commons Network^™

Understanding Populism Through Difference: The Significance Of Economic And Social Axes. An Interview With Kenneth Roberts, Cornell University, Kenneth Roberts, Kayla Bohannon, Alina Hechler

disClosure: A Journal of Social Theory

Kenneth M. Roberts is the Richard J. Schwartz Professor of Government and Binenkorb Director of Latin American Studies at Cornell University. His research and teaching interests focus on party systems, populism, social movements, and the politics of inequality in Latin America and beyond. He is the author of Changing Course in Latin America: Party Systems in the Neoliberal Era (Cambridge University Press) and Deepening Democracy? The Modern Left and Social Movements in Chile and Peru (Stanford University Press). He is also the co-editor of The Resurgence of the Latin American Left (Johns Hopkins University Press), The Diffusion of Social Movements …

The 2016 Bernie Sanders Campaign: American Socialist Populism, Judson C. Abraham

disClosure: A Journal of Social Theory

Some socialists criticize Bernie Sanders’s 2016 presidential campaign, taking issue with the senator’s nationalism, vague presentation of socialism and revolution, and seeming preoccupation with class at the expense of attention to racism. This article draws from Ernesto Laclau and Chantal Mouffe’s theorization of populism to depict Sanders’s campaign as a legitimately socialist project. Laclau and Mouffe claim that left populism may evolve into socialism under certain conditions. One may expect Sanders’s populism to empower previously uncommitted people to make socialist demands.

Reflections From A Lifetime Of Activism. An Interview With Chip Berlet, Chip Berlet, Kendall Sewell, Matthew Wentz, Austin Zinkle

disClosure: A Journal of Social Theory

Chip Berlet is a widely published independent scholar who studies right-wing movements in the United States and Europe, as well as the global spread of conspiracy theories. He is an award-winning investigative journalist and photographer. Since the 1995 Oklahoma bombing, Berlet has appeared frequently in the media to discuss these issues. For over twenty years, Berlet was a senior analyst at Political Research Associates (PRA), a non-profit think tank in the United States that tracks right-wing networks. Berlet is co-author (with Matthew N. Lyons) of Right-Wing Populism in America: Too Close for Comfort (Guilford 2000) and more recently editor of …

Covid-19 Is Spatial: Ensuring That Mobile Big Data Is Used For Social Good, Age Poom, Olle Järv, Matthew Zook, Tuuli Toivonen

Geography Faculty Publications

The mobility restrictions related to COVID-19 pandemic have resulted in the biggest disruption to individual mobilities in modern times. The crisis is clearly spatial in nature, and examining the geographical aspect is important in understanding the broad implications of the pandemic. The avalanche of mobile Big Data makes it possible to study the spatial effects of the crisis with spatiotemporal detail at the national and global scales. However, the current crisis also highlights serious limitations in the readiness to take the advantage of mobile Big Data for social good, both within and beyond the interests of health sector. We propose …

A Novel And Clinically Useful Dynamic Conformal Arc (Dca)-Based Vmat Planning Technique For Lung Sbrt, Damodar Pokhrel, Justin Visak, Lana Sanford

Radiation Medicine Faculty Publications

PURPOSE: Volumetric modulated arc therapy (VMAT) is gaining popularity for stereotactic treatment of lung lesions for medically inoperable patients. Due to multiple beamlets in delivery of highly modulated VMAT plans, there are dose delivery uncertainties associated with small-field dosimetry error and interplay effects with small lesions. We describe and compare a clinically useful dynamic conformal arc (DCA)-based VMAT (d-VMAT) technique for lung SBRT using flattening filter free (FFF) beams to minimize these effects.

MATERIALS AND METHODS: Ten solitary early-stage I-II non-small-cell lung cancer (NSCLC) patients were treated with a single dose of 30 Gy using 3-6 non-coplanar VMAT arcs (clinical …

Reactionary Populism And The Historical Erosion Of Democracy In America. An Interview With Nancy Maclean, Duke University, Nancy Maclean, Aimee Imlay, Matthew Wentz

disClosure: A Journal of Social Theory

Nancy MacLean is the William H. Chafe Professor of History and Public Policy at Duke University, and the award-winning author of several books, including Behind the Mask of Chivalry: The Making of the Second Ku Klux Klan; Freedom is Not Enough: The Opening of the American Workplace; The American Women’s Movement, 1945-2000: A Brief History with Documents; and Debating the American Conservative Movement: 1945 to the Present. She also served the editor of Scalawag: A White Southerner’s Journey through Segregation to Human Rights Activism.

Her scholarship has received more than a dozen major prizes and …

Racial And Ethnic Disparities In Covid-19: Evidence From Six Large Cities, Joseph Benitez, Charles J. Courtemanche, Aaron Yelowitz

Institute for the Study of Free Enterprise Working Papers

As of June 2020, the coronavirus pandemic has led to more than 2.3 million confirmed infections and 121 thousand fatalities in the United States, with starkly different incidence by race and ethnicity. Our study examines racial and ethnic disparities in confirmed COVID-19 cases across six diverse cities – Atlanta, Baltimore, Chicago, New York City, San Diego, and St. Louis – at the ZIP code level (covering 436 “neighborhoods” with a population of 17.7 million). Our analysis links these outcomes to six separate data sources to control for demographics; housing; socioeconomic status; occupation; transportation modes; health care access; long-run opportunity, as …

Southeastern Law Librarian Summer 2020, Seaall

Newsletters

No abstract provided.

Population Data-Driven Formulation Of A Covid-19 Therapeutic, Heather R. Campbell, Regan P. Cecil, Robert A. Lodder

Pharmaceutical Sciences Faculty Publications

This study is designed to utilize computer modeling of the US population through the ongoing CDC NHANES trial to reduce the need for preclinical formulation and toxicology studies of an Ebola antiviral (BSN389) being repurposed for COVID-19, and to thereby speed the candidate therapeutic to the clinic. BSN389 has poor solubility in water and that limits its bioavailability. BCD greatly increases the solubility of BSN389 and results in high bioavailability of BSN389 in animal studies. The goal of this study is to determine the current daily exposure of the population to beta cyclodextrin (BCD), and then keep the amount of …

Mobile Apps For Visual Research: Affordances And Challenges For Participant-Generated Photography, Sarah C. Barriage, Alison Hicks

Information Science Faculty Publications

The incorporation of participant-generated photography in research can be a powerful means of studying participants' perspectives and experiences. Approaches such as photovoice and photo-elicitation that incorporate participant-generated photography are increasingly being used in library and information science to study topics such as information needs, information seeking, and use of library space. This article describes two recent studies that used mobile apps (PixStori and EthOS) to facilitate participant-generated photography and photo-elicitation processes in research exploring the information practices of children and young adults, including the affordances, challenges and practical considerations identified by the researchers. Affordances of these apps within a research …

Extreme Elevations Of Alkaline Phosphatase In Pregnancy: A Case Report, Zachary Stanley, Katherine Vignes, Miriam Marcum

Obstetrics and Gynecology Faculty Publications

Background: The normal serum concentration of alkaline phosphatase (ALP) in adults over the age of 18 ranges from 37 to 116 U/L, while in pregnant women levels of up to twice that upper limit can still be normal. There have been very few reports of extreme elevations in ALP, and here we present the case of a 29-year-old pregnant woman with an incidentally found 30-fold increase.

Case: The patient, G6P2-1-2-4, received routine prenatal care, though presented to obstetric triage at 36 weeks and 1 day of gestation for diagnosis and management of viral rhinosinusitis and was found to have an …

Palbociclib Treatment Alters Nucleotide Biosynthesis And Glutamine Dependency In A549 Cells, Lindsey R. Conroy, Pawel Lorkiewicz, Liqing He, Xinmin Yin, Xiang Zhang, Shesh N. Rai, Brian F. Clem

Neuroscience Faculty Publications

Background

Aberrant activity of cell cycle proteins is one of the key somatic events in non-small cell lung cancer (NSCLC) pathogenesis. In most NSCLC cases, the retinoblastoma protein tumor suppressor (RB) becomes inactivated via constitutive phosphorylation by cyclin dependent kinase (CDK) 4/6, leading to uncontrolled cell proliferation. Palbociclib, a small molecule inhibitor of CDK4/6, has shown anti-tumor activity in vitro and in vivo, with recent studies demonstrating a functional role for palbociclib in reprogramming cellular metabolism. While palbociclib has shown efficacy in preclinical models of NSCLC, the metabolic consequences of CDK4/6 inhibition in this context are largely unknown.

Methods

In …

Thrower's Exostosis Of The Shoulder: A Systematic Review With A Novel Classification, Michael T. Freehill, Sandeep Mannava, Laurence D. Higgins, Alexandre Lädermann, Austin V. Stone

Orthopaedic Surgery and Sports Medicine Faculty Publications

Background: A variety of thrower's exostoses are grouped under the term Bennett lesion, which makes understanding diagnosis and treatment difficult.

Purpose: To identify all types of reported thrower's and overhead athlete's exostoses and categorize them into a classification system to allow a morphology-based classification.

Study Design: Systematic review; Level of evidence, 4.

Methods: A systematic review of all articles pertaining to Bennett lesions and thrower's exostosis was performed. The classification and treatments were evaluated to describe the types, proposed causes, diagnosis, and treatment options.

Results: A total of 27 studies were included in the systematic review. The anatomic locations …

Identifying Facets Of Reader-Generated Online Reviews Of Children’S Books Based On A Textual Analysis Approach, Yunseon Choi, Soohyung Joo

Information Science Faculty Publications

With the increasing popularity of social media, online reviews have become one of the primary information sources for book selection. Prior studies have analyzed online reviews, mostly in the domain of business. However, little research has examined the content of online book reviews of children’s books. Book reviews generated by book readers contain different aspects of information, such as opinions, feedback, or emotional responses, from the perspectives of readers. This study explores what aspects of the books are addressed in readers’ reviews, and then it intends to identify categorical features or facets of online book reviews of children’s books. We …

Efficacy Of Stem Cell Allograft In Maxillary Sinus Bone Regeneration: A Randomized Controlled Clinical And Blinded Histomorphometric Study, Josh Whitt, Mohanad Al-Sabbagh, Dolph R. Dawson Iii, Ehab Shehata, Moly Housley-Smith, Alejandro G. Villasante Tezanos, Ahmad Kutkut

Oral Health Practice Faculty Publications

Purpose: This study aimed to evaluate the quality and quantity of newly generated bone in the maxillary sinus grafted with stem cell-based allograft material.

Methods: This study was a single site, prospective, blinded, randomized, and controlled clinical trial. Eleven subjects with 18 edentulous posterior maxillary sites requiring sinus augmentation for delayed implant placement using a lateral window approach were enrolled. At the time of sinus augmentation, test sinus was grafted with stem cell-based allograft (Osteocel Plus; NuVasive Therapeutics), while the control sinus was grafted with conventional cortico-cancellous allograft (alloOss; ACE Surgical). Cone beam computer tomography (CBCT) scan was taken before …

Electrochemical Evaluation Of A Multi-Site Clinical Depth Recording Electrode For Monitoring Cerebral Tissue Oxygen, Ana Ledo, Eliana Fernandes, Jorge E. Quintero, Greg A. Gerhardt, Rui M. Barbosa

Neurosurgery Faculty Publications

The intracranial measurement of local cerebral tissue oxygen levels—PbtO₂—has become a useful tool for the critical care unit to investigate severe trauma and ischemia injury in patients. Our preliminary work in animal models supports the hypothesis that multi-site depth electrode recording of PbtO₂ may give surgeons and critical care providers needed information about brain viability and the capacity for better recovery. Here, we present a surface morphology characterization and an electrochemical evaluation of the analytical properties toward oxygen detection of an FDA-approved, commercially available, clinical grade depth recording electrode comprising 12 Pt recording contacts. We found that …

Viral Membrane Fusion And The Transmembrane Domain, Chelsea T. Barrett, Rebecca Ellis Dutch

Molecular and Cellular Biochemistry Faculty Publications

Initiation of host cell infection by an enveloped virus requires a viral-to-host cell membrane fusion event. This event is mediated by at least one viral transmembrane glycoprotein, termed the fusion protein, which is a key therapeutic target. Viral fusion proteins have been studied for decades, and numerous critical insights into their function have been elucidated. However, the transmembrane region remains one of the most poorly understood facets of these proteins. In the past ten years, the field has made significant advances in understanding the role of the membrane-spanning region of viral fusion proteins. We summarize developments made in the past …

Do Gun Policies Really Protect Women? A Cross-National Test Of The Relationship Between Gun Regulations And Female Homicide Victimization, Janet Stamatel, Kathleen Ratajczak, Robert Hoekstra

Sociology Faculty Publications

Globally, firearms are the most frequent means of committing homicide with young males most likely to be victimized with guns. However, within the context of intimate partner violence and family violence, females’ risk of lethal gun violence rises significantly, supporting the need to pay more attention to firearms to reduce lethal VAW. One way to protect women from firearm violence within the private sphere is to regulate access to guns based on the risk of family violence. This study examines the extent to which gun availability and gun regulations affect lethal violence against women in a relatively large sample of …

Spermine Synthase And Myc Cooperate To Maintain Colorectal Cancer Cell Survival By Repressing Bim Expression, Yubin Guo, Qing Ye, Pan Deng, Yanan Cao, Daheng He, Zhaohe Zhou, Chi Wang, Yekaterina Y. Zaytseva, Charles E. Schwartz, Eun Young Lee, B. Mark Evers, Andrew J. Morris, Side Liu, Qing-Bai She

Markey Cancer Center Faculty Publications

Dysregulation of polyamine metabolism has been linked to the development of colorectal cancer (CRC), but the underlying mechanism is incompletely characterized. Here, we report that spermine synthase (SMS), a polyamine biosynthetic enzyme, is overexpressed in CRC. Targeted disruption of SMS in CRC cells results in spermidine accumulation, which inhibits FOXO3a acetylation and allows subsequent translocation to the nucleus to transcriptionally induce expression of the proapoptotic protein Bim. However, this induction is blunted by MYC-driven expression of miR-19a and miR-19b that repress Bim production. Pharmacological or genetic inhibition of MYC activity in SMS-depleted CRC cells dramatically induces Bim expression and apoptosis …

Personality Disorders In The Icd-11: Spanish Validation Of The Picd And The Saspd In A Mixed Community And Clinical Sample, Fernando Gutiérrez, Anton Aluja, José Ruiz, Luis F. García, Miguel Gárriz, Alfonso Gutiérrez-Zotes, David Gallardo-Pujol, Maria V. Navarro-Haro, Miquel Alabèrnia-Segura, Joan Ignasi Mestre-Pintó, Marta Torrens, Josep M Peri, Bárbara Sureda, Joaquim Soler, Juan Carlos Pascual, Gemma Vall, Natalia Calvo, Marc Ferrer, Joshua R. Oltmanns, Thomas A. Widiger

Psychology Faculty Publications

The International Classification of Diseases–11th revision (ICD-11) classification of personality disorders is the official diagnostic system that is used all over the world, and it has recently been renewed. However, as yet very few data are available on its performance. This study examines the Personality Inventory for ICD-11 (PiCD), which assesses the personality domains of the system, and the Standardized Assessment of Severity of Personality Disorder (SASPD), which determines severity. The Spanish versions of the questionnaires were administered to a community (n = 2,522) and a clinical sample (n = 797). Internal consistency was adequate in the PiCD …

Evolving Role For Pharmacotherapy In Nafld/Nash, Suzanna L. Attia, Samir Softic, Marialena Mouzaki

Pediatrics Faculty Publications

Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent, dynamic disease that occurs across the age spectrum and can lead to cirrhosis and hepatocellular carcinoma. There are currently no US Food and Drug Administration (FDA) approved treatments for NAFLD; however, this is a field of active research. This review summarizes emerging pharmacotherapies for the treatment of adult and pediatric NAFLD. Investigated pharmacotherapies predominantly target bile acid signaling, insulin resistance, and lipid handling within the liver. Three drugs have gone on to phase III trials for which results are available. Of those, obeticholic acid is the single agent that demonstrates promise …

The Role Of Plant Richness & Diversity On Ecological Equilibrium Of Rangeland Habitats On Alborz Mountain (North Of Iran), D. Asgarizadeh, M. H. Jouri, V. Rahimi, J. Shahi

IGC Proceedings (1977-2023)

No abstract provided.

Alteration Of Tobacco Alkaloid Content Through Modification Of Specific Cytochrome P450 Genes, Ralph E. Dewey, Balazs Siminszky, Steven W. Bowen, Lily Gavilano

Plant and Soil Sciences Faculty Patents

Compositions and methods for reducing the level of nornicotine and N'-nitrosonomicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for cytochrome P450s that are involved in the metabolic con- version of nicotine to nornicotine in these plants. Expression cassettes, vectors, plants, and plant parts thereof comprising inhibitory sequences that target expression or function of the disclosed cytochrome P450 polypeptides are also provided. Methods for the use of these novel sequences to inhibit expression or function of cytochrome P450 polypeptides involved in this metabolic conversion are also provided. The methods find use …

Histone Deacetylase 3 Is Required For Development And Metamorphosis In The Red Flour Beetle, Tribolium Castaneum, Smitha George, Subba Reddy Palli

Entomology Faculty Publications

Background

Hormones are chemical communication signaling molecules released into the body fluids to stimulate target cells of multicellular organisms. We recently showed that histone deacetylase 1 (HDAC1) plays an important role in juvenile hormone (JH) suppression of metamorphosis in the red flour beetle, Tribolium castaneum. Here, we investigated the function of another class I HDAC member, HDAC3, and show that it is required for the normal development of T. castaneum.

Results

RNA interference-mediated knockdown of the HDAC3 gene affected development resulting in abnormally folded wings in pupae and adults. JH analog, hydroprene, suppressed the expression of HDAC3 in …

Assessing Diabetes Risk Factors In Rural Dwelling Grandparent Caregivers, Brittany L. Smalls, Adebola Olamide Adegboyega, Omar A. Contreras, Kelly Palmer, Jennifer Hatcher

Family and Community Medicine Faculty Publications

Objective:

The purpose of this study is to assess type 2 diabetes mellitus (T2DM) risk factors in grandparent caregivers living in a rural environment.

Methods:

Clinical measures (hemoglobin A1c [HbA1c], blood pressure, and lipids) and self-reported data on social environment factors were attained. Data were analyzed via Pearson’s correlation and regression models.

Results:

By clinical definition of diabetes (HbA1c ≥ 6.5%), 21% were prediabetic and 28% had undiagnosed T2DM. There was an association between the number of individuals in the home and triglycerides (r = −.25), high-density lipoproteins (HDL; r = .43), and body mass index (BMI; r = …

The Consequences Of Exercise-Induced Weight Loss On Food Reinforcement. A Randomized Controlled Trial, Kyle D. Flack, Harry M. Hays, Jack Moreland

Dietetics and Human Nutrition Faculty Publications

BACKGROUND: Obesity remains a primary threat to the health of most Americans, with over 66% considered overweight or obese with a body mass index (BMI) of 25 kg/m2 or greater. A common treatment option many believe to be effective, and therefore turn to, is exercise. However, the amount of weight loss from exercise training is often disappointingly less than expected with greater amounts of exercise not always promoting greater weight loss. Increases in energy intake have been prescribed as the primary reason for this lack of weight loss success with exercise. Research has mostly focused on alterations in hormonal mediators …

Circadian Disruption With Constant Light Exposure Exacerbates Atherosclerosis In Male Apolipoproteine-Deficient Mice, Jeffrey M. Chalfant, Deborah A. Howatt, Lisa R. Tannock, Alan Daugherty, Julie S. Pendergast

Biology Faculty Publications

Disruption of the circadian system caused by disordered exposure to light is pervasive in modern society and increases the risk of cardiovascular disease. The mechanisms by which this happens are largely unknown. ApolipoproteinE-deficient (ApoE^−/−) mice are studied commonly to elucidate mechanisms of atherosclerosis. In this study, we determined the effects of light-induced circadian disruption on atherosclerosis in ApoE^−/− mice. We first characterized circadian rhythms of behavior, light responsiveness, and molecular timekeeping in tissues from ApoE^−/− mice that were indistinguishable from rhythms in ApoE^+/+ mice. These data showed that ApoE^−/− mice had no inherent circadian …

Small Molecule Drug Release Form In Situ Forming Degradable Scaffolds Incorporating Hydrogels And Bioceramic Microparticles, David A. Puleo, Todd A. Milbrandt, J. Zach Hilt, Paul Fisher, Vishwas Talwalkar

Biomedical Engineering Faculty Patents

The present invention relates to an injectable system combining a hydrogel, a bioceramic and a degradable matrix that provides for sustained drug delivery and structural support to recovering tissue, such as bone and the periodontium.

Genome Diversity And The Origin Of The Arabian Horse, Elissa J. Cosgrove, Raheleh Sadeghi, Florencia Schlamp, Heather M. Holl, Mohammad Moradi-Shahrbabak, Seyed Reza Miraei-Ashtiani, Salma Abdalla, Ben Shykind, Mats H. T. Troedsson, Monika Stefaniuk-Szmukier, Anil Prabhu, Stefania Bucca, Monika Bugno-Poniewierska, Barbara Wallner, Joel Malek, Donald C. Miller, Andrew G. Clark, Douglas F. Antczak, Samantha A. Brooks

Veterinary Science Faculty Publications

The Arabian horse, one of the world's oldest breeds of any domesticated animal, is characterized by natural beauty, graceful movement, athletic endurance, and, as a result of its development in the arid Middle East, the ability to thrive in a hot, dry environment. Here we studied 378 Arabian horses from 12 countries using equine single nucleotide polymorphism (SNP) arrays and whole-genome re-sequencing to examine hypotheses about genomic diversity, population structure, and the relationship of the Arabian to other horse breeds. We identified a high degree of genetic variation and complex ancestry in Arabian horses from the Middle East region. Also, …

Resolving Metabolic Heterogeneity In Experimental Models Of The Tumor Microenvironment From A Stable Isotope Resolved Metabolomics Perspective, Teresa W-M Fan, Richard M. Higashi, Yelena Chernayavskaya, Andrew N. Lane

Center for Environmental and Systems Biochemistry Faculty Publications

The tumor microenvironment (TME) comprises complex interactions of multiple cell types that determines cell behavior and metabolism such as nutrient competition and immune suppression. We discuss the various types of heterogeneity that exist in solid tumors, and the complications this invokes for studies of TME. As human subjects and in vivo model systems are complex and difficult to manipulate, simpler 3D model systems that are compatible with flexible experimental control are necessary for studying metabolic regulation in TME. Stable Isotope Resolved Metabolomics (SIRM) is a valuable tool for tracing metabolic networks in complex systems, but at present does not directly …