Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

University of Kentucky

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 601 - 630 of 18291

Full-Text Articles in Entire DC Network

Probing Tau Citrullination In Alzheimer’S Disease Brains And Mouse Models Of Tauopathy, Huimin Liang, Jerry B. Hunt, Chao Ma, Andrii Kovalenko, John Calahatian, Cecelie Pedersen, Haiying Liu, Junyan Li, Malina Serrano, Danielle Blazier, Mallory Watler, Patricia Rocha-Rangel, Christopher Saunders, Laura J. Blair, Leonid Breydo, Kevin Nash, Zainuddin Quadri, Brian Kraemer, Peter Nelson, Christopher Norris, Erin L. Abner, Vladimir N. Uversky, Dale Chaput, Maj Linda B. Selenica, Daniel C. Lee Dec 2025

Probing Tau Citrullination In Alzheimer’S Disease Brains And Mouse Models Of Tauopathy, Huimin Liang, Jerry B. Hunt, Chao Ma, Andrii Kovalenko, John Calahatian, Cecelie Pedersen, Haiying Liu, Junyan Li, Malina Serrano, Danielle Blazier, Mallory Watler, Patricia Rocha-Rangel, Christopher Saunders, Laura J. Blair, Leonid Breydo, Kevin Nash, Zainuddin Quadri, Brian Kraemer, Peter Nelson, Christopher Norris, Erin L. Abner, Vladimir N. Uversky, Dale Chaput, Maj Linda B. Selenica, Daniel C. Lee

Epidemiology and Environmental Health Faculty Publications

Alzheimer’s disease (AD) includes a defining hallmark that correlates most closely to cognitive decline, namely misfolded tau protein. However, the “upstream” etiology and downstream clinical manifestations of tauopathies are quite diverse. Tau deposition elicits different pathological phenotypes and outcomes depending on the tau strain, proteoforms, and regional susceptibility. Posttranslational modifications (PTM) can alter tau structure, function, networks, and its pathological sequelae. We uncovered tau citrullination on multiple epitopes caused by peptidyl arginine deiminase (PAD) enzymes. PAD-induced citrullination irreversibly converts arginine residues to citrulline, producing a net loss of positive charge, elimination of pi–pi interactions, and increased hydrophobicity. We observed increased …

Go to article

Prospective Cohort Study Of Fentanyl Test Strip Use And Distribution In Three States, Janet E. Childerhose, Kitty Gelberg, Rachel Vickers-Smith, Megan E. Dzurec, Emmanuel Oga, Mallory Harris, Rachel Caspar, Denise C. Babineau, Megan E. Hall, Beth S. Linas, Katherine E. Marks, Amanda Fallin-Bennett, Laura C. Fanucchi, Louisa Gilbert, James L. David, Mary Russo, Kathryn E. Lancaster, Soledad Fernandez, Michael Konstan, Redonna K. Chandler, Carter Roeber, Jennifer Villani, Rebecca D. Jackson, Bridget Freisthler, Sharon L. Walsh, Nabila El-Bassel Dec 2025

Prospective Cohort Study Of Fentanyl Test Strip Use And Distribution In Three States, Janet E. Childerhose, Kitty Gelberg, Rachel Vickers-Smith, Megan E. Dzurec, Emmanuel Oga, Mallory Harris, Rachel Caspar, Denise C. Babineau, Megan E. Hall, Beth S. Linas, Katherine E. Marks, Amanda Fallin-Bennett, Laura C. Fanucchi, Louisa Gilbert, James L. David, Mary Russo, Kathryn E. Lancaster, Soledad Fernandez, Michael Konstan, Redonna K. Chandler, Carter Roeber, Jennifer Villani, Rebecca D. Jackson, Bridget Freisthler, Sharon L. Walsh, Nabila El-Bassel

Epidemiology and Environmental Health Faculty Publications

Background: The Stay Safe Study is the first observational prospective cohort study investigating fentanyl test strip (FTS) use by people who use drugs (PWUD) and distribution by community organizations that provide harm reduction services (e.g., naloxone distribution) in three states (Kentucky, New York, and Ohio). The purpose of this paper is to describe the study design, along with implementation successes and challenges. A related goal is to provide recommendations and encourage researchers to undertake multi-state and multilevel studies of FTS use and distribution. Methods: The Stay Safe Study has one primary, five secondary, and three exploratory objectives. From May-December 2023, …

Go to article

Referrals And Utilization Of Diabetes Self-Management Education And Support (Dsmes) Among Patients With Type 1 And Type 2 Diabetes At A Regional Medical Center In Kentucky, Omer Atac, George C. Bryant, William B. Burrows, Kory R. Heier, James W. Keck, Key C. Douthitt, Mary E. Lacy Dec 2025

Referrals And Utilization Of Diabetes Self-Management Education And Support (Dsmes) Among Patients With Type 1 And Type 2 Diabetes At A Regional Medical Center In Kentucky, Omer Atac, George C. Bryant, William B. Burrows, Kory R. Heier, James W. Keck, Key C. Douthitt, Mary E. Lacy

Epidemiology and Environmental Health Faculty Publications

Background: The goal of this study was to examine referral and attendance patterns for diabetes self-management education and support (DSMES) among patients with both type 1 (T1D) and type 2 diabetes (T2D) at a regional medical center in Kentucky, and to identify demographic and clinical factors associated with these outcomes. Methods: We analyzed electronic health records of adults with diabetes (n = 10,587; n = 817 with T1D and n = 9,770 with T2D) who received care from 1/1/2016-12/31/2019 at University of Kentucky HealthCare. We compared DSMES referral and attendance rates by various demographic and clinical factors and used logistic …

Go to article

Using The Practical, Robust Implementation And Sustainability Model To Identify Implementation Determinants Of A Statewide Diabetes Learning Collaborative In Kentucky, Aaron J. Kruse-Diehr, Borsika A. Rabin, Jessica Elliott, Vance Drakeford, Laura Wright, Brent Mckune, Russell E. Glasgow, Key C. Douthitt, James W. Keck, Mary E. Lacy Dec 2025

Using The Practical, Robust Implementation And Sustainability Model To Identify Implementation Determinants Of A Statewide Diabetes Learning Collaborative In Kentucky, Aaron J. Kruse-Diehr, Borsika A. Rabin, Jessica Elliott, Vance Drakeford, Laura Wright, Brent Mckune, Russell E. Glasgow, Key C. Douthitt, James W. Keck, Mary E. Lacy

Epidemiology and Environmental Health Faculty Publications

Background: Prevalence of type 2 diabetes (T2D) in Kentucky is among the highest in the United States. Diabetes self-management education and support (DSMES) is an evidence-based intervention that teaches people living with T2D to self-manage their disease but is underutilized in Kentucky despite being available free-of-charge to residents of every county. One promising strategy to improve DSMES utilization is clinic participation in a learning collaborative, wherein participants undertake small tests of change to improve the referral process. The purpose of this study was to identify determinants related to successful implementation of the learning collaborative, as well as perceived progress on …

Go to article

Multiple Bursts Of Speciation In Madagascar’S Endangered Lemurs, Kathryn M. Everson, Luca Pozzi, Meredith A. Barrett, Mary E. Blair, Mariah E. Donohue, Peter M. Kappeler, Andrew C. Kitchener, Alan R. Lemmon, Emily Moriarty Lemmon, Carlos J. Pavón-Vázquez, Ute Radespiel, Blanchard Randrianambinina, Rodin M. Rasoloarison, Solofonirina Rasoloharijaona, Christian Roos, Jordi Salmona, Anne D. Yoder, Rosana Zenil-Ferguson, Dietmar Zinner, David W. Weisrock Dec 2025

Multiple Bursts Of Speciation In Madagascar’S Endangered Lemurs, Kathryn M. Everson, Luca Pozzi, Meredith A. Barrett, Mary E. Blair, Mariah E. Donohue, Peter M. Kappeler, Andrew C. Kitchener, Alan R. Lemmon, Emily Moriarty Lemmon, Carlos J. Pavón-Vázquez, Ute Radespiel, Blanchard Randrianambinina, Rodin M. Rasoloarison, Solofonirina Rasoloharijaona, Christian Roos, Jordi Salmona, Anne D. Yoder, Rosana Zenil-Ferguson, Dietmar Zinner, David W. Weisrock

Biology Faculty Publications

Lemurs are often cited as an example of adaptive radiation, as more than 100 extant species have evolved and filled ecological niches on Madagascar. However, recent work suggests that lemurs lack a hallmark of other adaptive radiations: explosive speciation rates that decline over time. Thus, characterizing the tempo and mode of evolution in lemurs can reveal alternative ways that hyperdiverse clades arise over time, which might differ from traditional models. We explore lemur evolution using a phylogenomic dataset with broad taxonomic sampling that includes the lorisiforms of Asia and continental Africa. Our analyses reveal multiple bursts of diversification (without subsequent …

Go to article

Overdose Education And Naloxone Distribution In Jails, Timothy Hunt, Carrie B. Oser, Peter D. Friedmann, Nicole Mack, Peter Balvanz, Bridget Freisthler, Redonna K. Chandler, Karli Hochstatter, Daniel R. Harris, La Shawn Glasgow, Lauren D’Costa, Mary R. Russo, Barry Eggleston, Arnie Aldridge, Paul Bellair, Allyson G. Cogan, James L. David, Nabila El-Bassel, Dawn Goddard-Eckrich, Steve Gomori, Holly Hagan, Steve Hanson, Ja Nae Holloway, Elizabeth N. Kinnard, Charlie Knott, Michael W. Konstan, Sharon L. Walsh, Patricia A. Lebaron Dec 2025

Overdose Education And Naloxone Distribution In Jails, Timothy Hunt, Carrie B. Oser, Peter D. Friedmann, Nicole Mack, Peter Balvanz, Bridget Freisthler, Redonna K. Chandler, Karli Hochstatter, Daniel R. Harris, La Shawn Glasgow, Lauren D’Costa, Mary R. Russo, Barry Eggleston, Arnie Aldridge, Paul Bellair, Allyson G. Cogan, James L. David, Nabila El-Bassel, Dawn Goddard-Eckrich, Steve Gomori, Holly Hagan, Steve Hanson, Ja Nae Holloway, Elizabeth N. Kinnard, Charlie Knott, Michael W. Konstan, Sharon L. Walsh, Patricia A. Lebaron

Sociology Faculty Publications

Background: Opioid-related overdose is the leading cause of mortality among individuals recently released from incarceration in the U.S. Naloxone is an FDA-approved opioid antagonist medication designed to rapidly reverse opioid overdose. Despite evidence of its acceptability and effectiveness at reducing the risk of opioid overdose death after release from incarceration, only an estimated 25% of US jails provide naloxone upon release. This study examines the effectiveness of the HEALing Communities Study (HCS) Communities That HEAL (CTH) intervention on enhancing access to overdose education and naloxone distribution (OEND) in participating jails in Kentucky, New York, Massachusetts, and Ohio. Methods: Communities were …

Go to article

The Importance Of Contextually Specific Support Relationships In Implementing Programs To Link People To Medication For Opioid Use Disorder (Moud) Treatment During Reentry From County Jails, Margaret Mcgladrey, Marisa Booty, Susannah Stitzer, Hannah K. Knudsen, Sharon L. Walsh, Michael Goetz, Hallie Mattingly, Michelle Lofwall, Laura Fanucchi, Devin Oller, Amanda Fallin-Bennett, Carrie B. Oser Dec 2025

The Importance Of Contextually Specific Support Relationships In Implementing Programs To Link People To Medication For Opioid Use Disorder (Moud) Treatment During Reentry From County Jails, Margaret Mcgladrey, Marisa Booty, Susannah Stitzer, Hannah K. Knudsen, Sharon L. Walsh, Michael Goetz, Hallie Mattingly, Michelle Lofwall, Laura Fanucchi, Devin Oller, Amanda Fallin-Bennett, Carrie B. Oser

Sociology Faculty Publications

Background: This study uses the Practical, Robust, Implementation, and Sustainability Model (PRISM) and Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) model to describe how features of jail contexts are associated with the number of people linked to medication for opioid use disorder (MOUD) and sustainment of jail linkage programs implemented in Wave 1 of the HEALing Communities Study in Kentucky (HCS-KY) from 2021 to 22. The HCS-KY is part of a parallel-group, cluster-randomized wait-list controlled trial examining the effects of supporting wide-scale implementation of evidence-based practices to reduce opioid overdose deaths. One strategy involved implementation of MOUD linkage programs within …

Go to article

Assessing Patient Experiences And Priorities In Traumatic Brain Injury Health Care, Temitayo R. Okusanya, Madeline D. Furie, Sergey Tarima, Courtney O. Barry, Terri Deroon-Cassini, Yuka Kobayashi, Michael A. Mccrea, Kathleen S. Williams, Staci A. Young, Lindsay D. Nelson Dec 2025

Assessing Patient Experiences And Priorities In Traumatic Brain Injury Health Care, Temitayo R. Okusanya, Madeline D. Furie, Sergey Tarima, Courtney O. Barry, Terri Deroon-Cassini, Yuka Kobayashi, Michael A. Mccrea, Kathleen S. Williams, Staci A. Young, Lindsay D. Nelson

Biostatistics Faculty Publications

Improving patient experiences and outcomes of traumatic brain injury (TBI) will require understanding patient perspectives of current care systems. Experts have called for building more integrated, patient-centered systems of care to better support patients through stages of TBI recovery. Informed by an earlier qualitative study, we conducted a survey to quantify patient perspectives on discharge and post-discharge experiences across seven hospitals in a single southeastern Wisconsin health system. Eligible participants were English or Spanish speakers and received TBI care between February 2023 and June 2024 at one level I trauma center emergency department (ED) and inpatient unit, two level III …

Go to article

A Bioinformatic Survey Of Rna Isoform Diversity And Expression Across 9 Gtex Tissues Using Long-Read Sequencing Data, Madeline L. Page, Bernardo Aguzzoli Heberle, J. Anthony Brandon, Mark E. Wadsworth, Lacey A. Gordon, Kayla A. Nations, David W. Fardo, Mark T.W. Ebbert Dec 2025

A Bioinformatic Survey Of Rna Isoform Diversity And Expression Across 9 Gtex Tissues Using Long-Read Sequencing Data, Madeline L. Page, Bernardo Aguzzoli Heberle, J. Anthony Brandon, Mark E. Wadsworth, Lacey A. Gordon, Kayla A. Nations, David W. Fardo, Mark T.W. Ebbert

Biostatistics Faculty Publications

Background: Even though alternative RNA splicing was discovered nearly 50 years ago (1977), we still understand very little about most isoforms arising from a single gene, including in which tissues they are expressed and if their functions differ. Human gene annotations suggest remarkable transcriptional complexity, with approximately 252,798 distinct RNA isoform annotations from 62,710 gene bodies (Ensembl v109; 2023), emphasizing the need to understand their biological effects. For example, 256 gene bodies have ≥ 50 annotated isoforms, and 30 have ≥ 100, where one protein-coding gene (MAPK10) even has 192 distinct RNA isoform annotations. Whether such isoform diversity results from …

Go to article

Association Of Genetic Scores Related To Insulin Resistance With Neurological Outcomes In Ancestrally Diverse Cohorts From The Trans-Omics For Precision Medicine (Topmed) Program, Chloé Sarnowski, Yixin Zhang, Farah Ammous, Lincoln M.P. Shade, Daniel Dicorpo, Xueqiu Jian, Donna K. Arnett, Thomas R. Austin, Alexa Beiser, Joshua C. Bis, John Blangero, Eric Boerwinkle, Jan Bressler, Joanne E. Curran, Charles S. Decarli, Harsha Doddapaneni, Josée Dupuis, David W. Fardo, Jose C. Florez, Stacey Gabriel, Richard A. Gibbs, David C. Glahn, Namrata Gupta, Hector M. González Dec 2025

Association Of Genetic Scores Related To Insulin Resistance With Neurological Outcomes In Ancestrally Diverse Cohorts From The Trans-Omics For Precision Medicine (Topmed) Program, Chloé Sarnowski, Yixin Zhang, Farah Ammous, Lincoln M.P. Shade, Daniel Dicorpo, Xueqiu Jian, Donna K. Arnett, Thomas R. Austin, Alexa Beiser, Joshua C. Bis, John Blangero, Eric Boerwinkle, Jan Bressler, Joanne E. Curran, Charles S. Decarli, Harsha Doddapaneni, Josée Dupuis, David W. Fardo, Jose C. Florez, Stacey Gabriel, Richard A. Gibbs, David C. Glahn, Namrata Gupta, Hector M. González

Biostatistics Faculty Publications

To better characterize the potential biological mechanisms underlying insulin resistance (IR) and dementia, we derive cross-population and population specific polygenic scores [PSs] for fasting insulin and IR-related partitioned PSs [pPSs]. We conduct a cross-sectional study of the associations of these genetic scores with neurological outcomes in >17k participants (36% men, mean age 55 yrs) from the Trans-Omics for Precision Medicine (TOPMed) program (50% Non-Hispanic White, 23% Black/African American, 21% Hispanic/Latino American, and 4% Asian American). We report significant negative associations (P < 0.002) of the cross-population (P = 1.3 × 10-5) and European (PEA = 3.0 × 10-8) fasting insulin PSs with total cranial volume, …

Go to article

Do Communities Implementing The Communities That Heal Intervention Have Significantly Lower Rates Of High-Risk Opioid Prescribing And Dispensing?, Frances R. Levin, Douglas R. Oyler, Denise C. Babineau, Jennifer Villani, Redonna K. Chandler, Patricia R. Freeman, Daniel P. Alford, Naleef Fareed, Nicole Mack, Trang Q. Nguyen, Daniel M. Walker, Joella Adams, Trevor J. Baker, Donna Beers, Shoshana N. Benjamin, Jennifer Bhuiyan, Derek Blevins, James L. David, Netrali Dalvi, Lauren D'Costa, Daniel J. Feaster, La Shawn Glasgow, Dawn A. Goddard-Eckrich, Yi Han, Mallory Harris, Timothy Hunt, Charles Knott, Adrienne Matson Dec 2025

Do Communities Implementing The Communities That Heal Intervention Have Significantly Lower Rates Of High-Risk Opioid Prescribing And Dispensing?, Frances R. Levin, Douglas R. Oyler, Denise C. Babineau, Jennifer Villani, Redonna K. Chandler, Patricia R. Freeman, Daniel P. Alford, Naleef Fareed, Nicole Mack, Trang Q. Nguyen, Daniel M. Walker, Joella Adams, Trevor J. Baker, Donna Beers, Shoshana N. Benjamin, Jennifer Bhuiyan, Derek Blevins, James L. David, Netrali Dalvi, Lauren D'Costa, Daniel J. Feaster, La Shawn Glasgow, Dawn A. Goddard-Eckrich, Yi Han, Mallory Harris, Timothy Hunt, Charles Knott, Adrienne Matson

Biostatistics Faculty Publications

Introduction: Prescription opioids can contribute to risk for opioid use disorder and overdoses. Improving prescription opioid safety is a critical component in reducing opioid risks. This report aims to determine whether communities randomized to the Communities That HEAL (CTH) intervention have significantly different rates of prescription opioid safety measures. Study Design: A multisite, 2-arm, community-level, cluster randomized, unblinded, wait-list controlled comparison trial designed to assess the effectiveness of the CTH intervention in reducing opioid-related overdose deaths among community residents 18 years of age or older (adults). Setting/Participants: Sixty-seven (67) communities in Kentucky, Massachusetts, New York, and Ohio. “Participants” were communities …

Go to article

Drug Overdose Deaths In Kentucky, 2019–2024, Aaron P. Smith, Juan Lang, Carmen Canedo, Patricia R. Freeman, Lindsey R. Hammerslag, Daniel R. Harris, Amber Kizewski, Peter Rock, Nima M. Seyedtalebi, Philip M. Westgate, Jeffery Talbert, Sharon L. Walsh, Svetla Slavova Dec 2025

Drug Overdose Deaths In Kentucky, 2019–2024, Aaron P. Smith, Juan Lang, Carmen Canedo, Patricia R. Freeman, Lindsey R. Hammerslag, Daniel R. Harris, Amber Kizewski, Peter Rock, Nima M. Seyedtalebi, Philip M. Westgate, Jeffery Talbert, Sharon L. Walsh, Svetla Slavova

Biostatistics Faculty Publications

Background: Kentucky has historically experienced a high burden of drug overdose deaths. During the first years of the COVID-19 pandemic, the state saw a 45% increase in overdose deaths in 2020, followed by an additional 15% increase in 2021. However, drug overdose deaths declined in 2023 and 2024. This study used electronic death certificate records from the Kentucky Office of Vital Statistics (2019–2024) to evaluate whether Kentucky’s 2024 drug overdose death rates have declined to pre-pandemic levels and if declines were observed across all demographic groups. The results from Poisson regressions are reported as rate ratios (RRs) and their 95% …

Go to article

Quantifying Nuanced Differences In Hand Dexterity Between The Dominant And Nondominant Hands Of Healthy, Right-Handed, Young Adults, Brian J. Conway, Léon Taquet, Timothy F. Boerger, Kaitlin Goetschel, Kate B. Krucoff, Sergey Tarima, Brian D. Schmit, Max O. Krucoff Dec 2025

Quantifying Nuanced Differences In Hand Dexterity Between The Dominant And Nondominant Hands Of Healthy, Right-Handed, Young Adults, Brian J. Conway, Léon Taquet, Timothy F. Boerger, Kaitlin Goetschel, Kate B. Krucoff, Sergey Tarima, Brian D. Schmit, Max O. Krucoff

Biostatistics Faculty Publications

When individuals present with hand injuries, clinicians often use the contralateral hand as an internal control. However, subtle differences in baseline dexterous abilities between the dominant and nondominant hands are poorly understood. To address this gap, here we quantified such differences, measured as independence (individuation) and smoothness of finger movements. A cohort of 47 right-hand-dominant healthy adults (22 males and 25 females) moved each finger independently 10 times, while joint angle data were tracked with a dataglove (CyberGlove III, CyberGlove Systems, San Jose, CA). Each finger’s performance was compared with its counterpart on the opposite hand using Wilcoxon-signed rank tests. …

Go to article

Using An Intersectional Framework To Explore Cannabis And Tobacco Co-Use Patterns, Bethany Shorey Fennell, Cherell Cottrell-Daniels, Kory Heier, Kristen Mcquerry Dec 2025

Using An Intersectional Framework To Explore Cannabis And Tobacco Co-Use Patterns, Bethany Shorey Fennell, Cherell Cottrell-Daniels, Kory Heier, Kristen Mcquerry

Biostatistics Faculty Publications

Cannabis and tobacco co-use is an emerging public health concern linked to increased dependence and reduced cessation success for both substances. However, little is known about how co-use patterns vary by product type, motivation, and demographic characteristics. This protocol outlines a cross-sectional study designed to characterize the frequency, type, and context of cannabis and tobacco co-use among U.S. adult tobacco users using an intersectional framework. A national sample of adults who used tobacco in the past 30 days (N = 3777) were recruited via CloudResearch Prime Panels. Participants completed detailed measures of tobacco and cannabis use, co-use behaviors, motivations, expectancies, …

Go to article

Radon And Tobacco Risk Counseling During Lung Cancer Screening Shared Decision-Making, Stacy R. Stanifer, Kathy Rademacher, Whitney Sedio, Naomi Cheek, Amanda Thaxton Wiggins, Mary Kay Rayens, Ellen J. Hahn Dec 2025

Radon And Tobacco Risk Counseling During Lung Cancer Screening Shared Decision-Making, Stacy R. Stanifer, Kathy Rademacher, Whitney Sedio, Naomi Cheek, Amanda Thaxton Wiggins, Mary Kay Rayens, Ellen J. Hahn

Biostatistics Faculty Publications

Objective: Examine frequency of tobacco and radon risk counseling during lung cancer screening shared decision making among qualified health care providers and the relationship between radon beliefs, tobacco and radon counseling self-efficacy, and related tobacco and radon risk counseling among providers. Methods: Cross-sectional, observational study design employing a mailed self-report survey sent to a stratified random sample of 1,000 qualified health care providers in Kentucky. Regression analyses to examine the association among sociodemographic characteristics, radon beliefs, self-efficacy, familiarity with lung cancer screening guidelines, and tobacco or radon risk reduction counseling during lung cancer screening shared decision making. Results: In all, …

Go to article

Acute Effects Of Lactate Infusion On Metabolism, Ad Biomarkers, And Cognition, Riley E. Kemna, Paul J. Kueck, Anneka Blankenship, Casey S. John, Chelsea N. Johnson, Zachary D. Green, Hana Mayfield, Lauren Yoksh, Lance Johnson, John P. Thyfault, Jonathan D. Mahnken, Benjamin F. Miller, Jill K. Morris Dec 2025

Acute Effects Of Lactate Infusion On Metabolism, Ad Biomarkers, And Cognition, Riley E. Kemna, Paul J. Kueck, Anneka Blankenship, Casey S. John, Chelsea N. Johnson, Zachary D. Green, Hana Mayfield, Lauren Yoksh, Lance Johnson, John P. Thyfault, Jonathan D. Mahnken, Benjamin F. Miller, Jill K. Morris

Physiology Faculty Publications

BACKGROUND: Impaired cerebral glucose metabolism is a hallmark of Alzheimer's disease (AD). Lactate is an alternative brain fuel; however, whole-body lactate metabolism has not been measured in AD. METHODS: The Lactate for Energy and Neurocognition Trial (NCT05207397) was a single-arm trial that enrolled 24 cognitively healthy (CH) older adults and 12 cognitively impaired (CI) participants. Subjects underwent a stable isotope lactate infusion to evaluate lactate metabolism, cognitive testing, and blood biomarker analyses. pTau217, brain-derived tau (BD-tau), pTau181, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), total tau, and brain-derived neurotrophic factor (BDNF) were analyzed by Simoa HD-X (Quanterix). RESULTS: …

Go to article

Direct Measurement Of Mavacamten And Deoxyatp Perturbation Of The Srx/Drx Ratio In Porcine Cardiac Myofibrils Using A Simple, Accessible And Multiplexed Approach, Matvey Pilagov, Ateeqa Naim, Kenneth S. Campbell, Thomas Kampourakis, Michael A. Geeves, Neil M. Kad Dec 2025

Direct Measurement Of Mavacamten And Deoxyatp Perturbation Of The Srx/Drx Ratio In Porcine Cardiac Myofibrils Using A Simple, Accessible And Multiplexed Approach, Matvey Pilagov, Ateeqa Naim, Kenneth S. Campbell, Thomas Kampourakis, Michael A. Geeves, Neil M. Kad

Physiology Faculty Publications

Cardiac muscle adapts to varying physiological demands by modulating the number of active myosin II motors available for contraction. These motors are organized into thick filaments in the sarcomere and generate force through an ATP-dependent interaction with thin filaments that contain actin. To conserve energy, when demand is low myosin can occupy the super-relaxed (SRX) state, which acts as a reserve. Here, we build upon the earlier studies to quantify the size of this cardiac reserve using fluorescence imaging of Cy3-ATP directly in myofibrils. This approach employs a pulse-chase method and exploits the high permeability of isolated myofibrils to monitor …

Go to article

Genomic, Transcriptomic, And Immunogenomic Landscape Of Over 1300 Sarcomas Of Diverse Histology Subtypes, Alex Soupir, Oscar E. Ospina, Oliver Hampton, Michelle Churchman, Michael Radmacher, Dale Hedges, David Mckean, Phaedra Agius, Saman Zeeshan, Nathan D. Seligson, Raphael Pollock, David Liebner, James L. Chen, Gabriel Tinoco, Bodour Salhia, Martin Mccarter, Breelyn A. Wilky, Benjamin J. Miller, Michael J. Cavnar, John S. Groundland, Bryan P. Schneider, Gregory Riedlinger, Stephen B. Edge, Christopher A. Moskaluk, Kenneth Cardona, Abdul Rafeh Naqash, Ricardo J. Gonzalez, John E. Mullinax Dec 2025

Genomic, Transcriptomic, And Immunogenomic Landscape Of Over 1300 Sarcomas Of Diverse Histology Subtypes, Alex Soupir, Oscar E. Ospina, Oliver Hampton, Michelle Churchman, Michael Radmacher, Dale Hedges, David Mckean, Phaedra Agius, Saman Zeeshan, Nathan D. Seligson, Raphael Pollock, David Liebner, James L. Chen, Gabriel Tinoco, Bodour Salhia, Martin Mccarter, Breelyn A. Wilky, Benjamin J. Miller, Michael J. Cavnar, John S. Groundland, Bryan P. Schneider, Gregory Riedlinger, Stephen B. Edge, Christopher A. Moskaluk, Kenneth Cardona, Abdul Rafeh Naqash, Ricardo J. Gonzalez, John E. Mullinax

Surgery Faculty Publications

Given their rarity and diversity, a fundamental understanding of the genomic underpinnings for many sarcoma subtypes is still lacking. To better define the molecular landscape of this group of diseases, we perform matched whole exome sequencing and RNA sequencing on a cohort of 1340 sarcoma tumor specimens. We identify recurrent somatic mutations and observe an increased mutational burden in metastatic vs. primary samples (p < 0.001). We observe frequent copy number alterations including whole genome doubling, with this feature being more common in metastatic tumors (p = 0.026). Estimation of immune cell abundances followed by hierarchical clustering identifies five immune subtypes ranging from low to high and we observe inferior overall survival in immune deplete clusters compared to immune enriched (p < 0.01). Interestingly, GIST predominantly form a distinct “immune intermediate” cluster that is marked by a specific enrichment for NK cells (FDR < 0.01).

Go to article

Mir-181a-5p Mediates The Effects Of Bmp4 On Intestinal Cell Proliferation And Differentiation, Chang Li, Yuning Zhou, Zhijie Yin, Yinping Jiang, Jinpeng Liu, Heidi L. Weiss, Qingding Wang, B. Mark Evers Dec 2025

Mir-181a-5p Mediates The Effects Of Bmp4 On Intestinal Cell Proliferation And Differentiation, Chang Li, Yuning Zhou, Zhijie Yin, Yinping Jiang, Jinpeng Liu, Heidi L. Weiss, Qingding Wang, B. Mark Evers

Surgery Faculty Publications

The intestinal mucosa undergoes a dynamic process of continual proliferation, differentiation, and apoptosis. Delineating the mechanisms involved in intestinal epithelial cell (IEC) differentiation is crucial to our understanding of not only normal gut adaptation but also aberrant intestinal growth. Bone morphogenetic protein (BMP) signaling is a pivotal regulator of intestinal proliferation and differentiation. However, the molecular underpinnings of the BMP pathway in this context are not entirely known. Here, we show a key role for the BMP4/microRNA (miR)-181/glycolysis signaling pathway in the maintenance of intestinal epithelial cell proliferation and differentiation. Treatment with BMP4 increased the expression of enterocyte markers and …

Go to article

Barriers And Facilitating Factors For Covid-19 Vaccination In Rural Appalachia, Kathryn M. Cardarelli, Rachel Gillespie, Anna Goodman Hoover, Diane B. Francis, Marc T. Kiviniemi Dec 2025

Barriers And Facilitating Factors For Covid-19 Vaccination In Rural Appalachia, Kathryn M. Cardarelli, Rachel Gillespie, Anna Goodman Hoover, Diane B. Francis, Marc T. Kiviniemi

Epidemiology and Environmental Health Faculty Publications

Background: Since the onset of the pandemic, COVID-19 mortality has disproportionately impacted populations impacted by health inequities. This study aimed to identify the barriers and facilitators to COVID-19 vaccination uptake in Appalachian Kentucky as a first step to developing vaccination interventions. Methods: Key informant interviews were conducted with 36 community leaders in 14 Appalachian Kentucky counties from January-June 2023. Interviews focused on leaders’ perspectives about their community’s COVID-19 experiences, community impacts of the pandemic, and vaccine facilitators and barriers in their communities. Iterative inductive-deductive coding was used to characterize responses. Results: There were barriers and facilitators at multiple levels of …

Go to article

Hiring Expectations For New And Future Workers In Animal Genetics Careers, Meghan C. Wulster-Radcliffe, James N. Macleod, Robert J. Coleman, John S. Radcliffe, Rebekah B. Epps, Carol D. Hanley, Cheyenne S. Summers, Steven A. Zinn, Sarah A. Reed Dec 2025

Hiring Expectations For New And Future Workers In Animal Genetics Careers, Meghan C. Wulster-Radcliffe, James N. Macleod, Robert J. Coleman, John S. Radcliffe, Rebekah B. Epps, Carol D. Hanley, Cheyenne S. Summers, Steven A. Zinn, Sarah A. Reed

Animal and Food Sciences Faculty Publications

To better align educational outcomes with workforce demands in animal and equine genetics, this study surveyed 65 industry professionals on entry-level competencies, hiring trends, and graduate preparedness of undergraduate students. The survey assessed employer ratings on the importance and perceived proficiency of seven core competencies: critical thinking, communication, teamwork, leadership, professionalism, career/self-development, and equity/inclusion, as well as technical knowledge and broader skills relevant to animal breeding and genetics. Results revealed oral communication, teamwork, and work ethic were rated as the most critical transferable skills, though notable proficiency gaps persist, particularly in leadership and professionalism. Foundational technical knowledge in genetics, molecular …

Go to article

High-Throughput Screens Identify Genotype-Specific Therapeutics For Channelopathies, Christian L. Egly, Alex Shen, Tri Q. Do, Carlos Tellet Cabiya, Paxton A. Ritschel, Suah Woo, Matthew Ku, Brian P. Delisle, Brett M. Kroncke, Björn C. Knollmann Nov 2025

High-Throughput Screens Identify Genotype-Specific Therapeutics For Channelopathies, Christian L. Egly, Alex Shen, Tri Q. Do, Carlos Tellet Cabiya, Paxton A. Ritschel, Suah Woo, Matthew Ku, Brian P. Delisle, Brett M. Kroncke, Björn C. Knollmann

Physiology Faculty Publications

Genetic diseases such as ion channelopathies substantially burden human health. Existing treatments are limited and not genotype specific. Here, we report a 2-step high-throughput approach to rapidly identify drug candidates for repurposing as genotype-specific therapy. We first screened 1,680 medicines using a thallium-flux trafficking assay against Kv11.1 gene variants causing long QT syndrome (LQTS), an ion channelopathy associated with fatal cardiac arrhythmia. We identified evacetrapib as a suitable drug candidate that improves membrane trafficking and activates channels. We then used deep mutational scanning to prospectively identify all Kv11.1 missense variants in an LQTS hotspot region responsive to treatment with evacetrapib. …

Go to article

Trajectories Of Recovery After Acute And Critical Illness (Tracer), Felipe González-Seguel, Louisa A. Summers, Lindsey E. Fresenko, Douglas E. Long, Logan N. Scott, Stacey A. Slone, Srushan Shankara Bhaktula, Yuan Wen, Benjamin F. Miller, Peter E. Morris, Amy L. Salyer, Anna G. Kalema, Ashley A. Montgomery-Yates, Esther E. Dupont-Versteegden, Kirby P. Mayer, Isabelle D. Bach, Davis A. Englund, Zachary R. Hettinger, Ahmed Ismaeel, Audrey M. Johnson, Philip A. Kern, Gerald V. Klim, Allison M. Owen, Jocelyn C. Porchia, Heba H. Qaissi Nov 2025

Trajectories Of Recovery After Acute And Critical Illness (Tracer), Felipe González-Seguel, Louisa A. Summers, Lindsey E. Fresenko, Douglas E. Long, Logan N. Scott, Stacey A. Slone, Srushan Shankara Bhaktula, Yuan Wen, Benjamin F. Miller, Peter E. Morris, Amy L. Salyer, Anna G. Kalema, Ashley A. Montgomery-Yates, Esther E. Dupont-Versteegden, Kirby P. Mayer, Isabelle D. Bach, Davis A. Englund, Zachary R. Hettinger, Ahmed Ismaeel, Audrey M. Johnson, Philip A. Kern, Gerald V. Klim, Allison M. Owen, Jocelyn C. Porchia, Heba H. Qaissi

Physiology Faculty Publications

Introduction Patients who survive admission to intensive care unit (ICU) for critical illness are at high risk of developing muscle atrophy and weakness, commonly diagnosed as ICU-acquired weakness (ICUAW). The development of ICUAW is closely linked to long-term symptoms and impairments known as post-intensive care syndrome (PICS). Despite heightened recognition of impairments, there is limited research supporting effective interventions to improve muscle and physical outcomes after hospital discharge. Prior to developing and testing interventions for ICU survivors, it is imperative to understand the trajectory of muscle and physical function recovery following an ICU stay. The purpose of this study is …

Go to article

Introducing Neuro Social Work: A Brief Reflection On Neuroscience And The Profession, Priscila Llamosa Nov 2025

Introducing Neuro Social Work: A Brief Reflection On Neuroscience And The Profession, Priscila Llamosa

Social Work Faculty Publications

Neuroscience offers language and evidence that can strengthen interdisciplinary communication, support advocacy in biomedically dominated settings, and validate relational practices long recognized in social work, including the impacts of early adversity, attachment, and healing through connection. At the same time, an epistemological tension underlies the profession’s unease with neuroscience when brain-based narratives are used to individualize structural harm or justify surveillance of marginalized families and communities. This teaching note introduces Neuro Social Work as a justice-oriented specialization that integrates contemporary neuroscience with social work’s person-in-environment commitments, relational practice traditions, and anti-oppressive ethics.The author argues that the key question is no …

Go to article

Introducing Neuro Sscial Work: A Brief Reflection On Neuroscience And The Profession, Priscila Llamosa Nov 2025

Introducing Neuro Sscial Work: A Brief Reflection On Neuroscience And The Profession, Priscila Llamosa

Social Work Faculty Publications

This reflection introduces and contextualizes the term Neuro Social Work, which I coin to name a specialized practice area at the intersection of social work, neuroscience, and neurodiversity. Drawing on my experience as a social work educator and practitioner, I discuss social work’s uneasy relationship with neuroscience, marked both by the opportunity to deepen our understanding of trauma, development, and healing, and by the risks of using brain‑based evidence to individualize structural harms or justify surveillance of marginalized communities. I outline, in broad strokes, what distinguishes Neuro Social Work from general neuroscience‑informed practice. The note is intended as a concept …

Go to article

The Next Generation, Jeremiah Chin Nov 2025

The Next Generation, Jeremiah Chin

Kentucky Law Journal

No abstract provided.

Go to article

New Challenges To Judicial Federalism, James A. Gardner Nov 2025

New Challenges To Judicial Federalism, James A. Gardner

Kentucky Law Journal

No abstract provided.

Go to article

Governors Slightly More Bound? A Critique Of The Uniform Law Commission's Model Public-Health Emergency Authority Act, Paul A. Diller Nov 2025

Governors Slightly More Bound? A Critique Of The Uniform Law Commission's Model Public-Health Emergency Authority Act, Paul A. Diller

Kentucky Law Journal

No abstract provided.

Go to article

Courting Jural Rights: The Kentucky Constitution And The Super Common Law Of Torts, Sarah L. Swan Nov 2025

Courting Jural Rights: The Kentucky Constitution And The Super Common Law Of Torts, Sarah L. Swan

Kentucky Law Journal

No abstract provided.

Go to article

Foreword, Sean Harrison Nov 2025

Foreword, Sean Harrison

Kentucky Law Journal

No abstract provided.

Go to article

First Prev Next Last