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Pharmacokinetics And Reward-Related Behaviors Of Ethanol In Male And Female Japanese Quail (Coturnix Japonica), Shannon Eaton

Theses and Dissertations--Psychology

Ethanol is one of the most widely used and abused drugs. Problem use is associated with many different health problems and the economic burden is in the billions of dollars. Additionally, many people have difficulty controlling their ethanol consumption and about 5% of adults end up with an alcohol use disorder (AUD). Many people with an AUD often find themselves in a cycle of binge, remission, and relapse.

Following ethanol consumption ethanol enters the bloodstream from the small intestine where it gets distributed to peripheral tissues. Ethanol in the bloodstream is cleared from the system by the liver. The primary …

The Role Of Alexithymia And Affective Lability In Disordered Eating Behaviors, Anna Marie Lilia Ortiz

Theses and Dissertations--Psychology

Affective distress may influence eating disorder behaviors in multiple ways. Affective lability refers to the tendency to experience frequent and striking fluctuations in mood. There is considerable evidence that it predicts eating disorder symptoms. Further, alexithymia is characterized by difficulties identifying and describing feelings and an externally oriented thinking style. Alexithymia has also been implicated in the development and maintenance of eating disorders. To date, these risk factors have been studied separately. Given the evidence that both alexithymia and affective lability are affective components associated with eating disordered behaviors, it may be important to examine possible relationships among alexithymia, affective …

A Test Of The “Teachable Moment” Heuristic’S Relevance For Understanding Cancer Survivors’ Health Behavior Motivation And Performance: A Cross-Sectional Study, Gabriella Puleo

Theses and Dissertations--Psychology

Cancer diagnosis has potential to motivate health behavior changes to promote better health outcomes. The Teachable Moment Heuristic is a parsimonious, transtheoretical framework for understanding the conditions under which behavior change might occur, with constructs that include affective, cognitive, and social factors. This exploratory study aimed to measure the three primary constructs of the Teachable Moment, evaluate the extent to which they are associated with cancer survivors’ motivation to adopt favorable health behaviors, and explore their potential as a model for health behavior performance. Participants (n = 93) in this cross-sectional study were adult breast, prostate, colorectal, lung, and …

How I Can Be Me: Associations Between Presentation Discrepancy And Mental Health Outcomes Among Lgbtq Adults, Samuel Bruun

Theses and Dissertations--Psychology

One’s perception of their own personal appearance, and how one is viewed by others has been previously shown to have an impact on one’s mental health. Whether it be dealing with unrealistic body expectations depicted in the media, or attempting to appear sufficiently masculine, there are a multitude of ways in which one’s appearance can cause distress. Some appearance challenges are more identity specific, such as the struggles that some transgender people experience when attempting to achieve affirming gender presentation. Although these different concerns have been addressed individually in past research, there has not been an attempt to determine how …

Parent School Involvement, Student School Engagement, And Academic Achievement In Children Adopted From Foster Care By Lesbian And Gay Parents, Cassandra P. Vazquez

Theses and Dissertations--Psychology

Sparse research has examined academic outcomes of children adopted from foster care by lesbian and gay (LG) parents. Children who have experienced foster care are at greater risk for negative outcomes, but investment in academic achievement could help buffer potential adversity. Parent and student engagement with school peaks in middle childhood, so this may be an important period for understanding processes that influence academic achievement. This study explores how LG parents (N = 57) of school-aged children (Mage = 10.56 years) adopted from foster care in the U.S. involve themselves in their child’s school, how this involvement may …

Adhd-Internalizing Disorder Co-Occurrence In Childhood And Adolescence: Comparing Network And Latent Variable Conceptualizations, Patrick Kenneth Goh

Theses and Dissertations--Psychology

Co-occurrence of attention-deficit/hyperactivity disorder (ADHD) with depression or anxiety (i.e., internalizing disorders) is a major route to poor outcomes, with temperament traits presenting as potential shared risk markers that underlie these disorders’ development and characterization. Prior work investigating the nature of ADHD-internalizing disorder co-occurrence using structural equation modeling has provided support for both temperament-based common cause (i.e., effortful control and negative affect as liabilities for multiple disorders) and direct causation (i.e., ADHD directly contributing to risk for internalizing disorders) effects separately. Using a network approach, the current study represented the first attempt to integrate these effects into one model while …

Trauma-Related Shame And Guilt As Prospective Predictors Of Daily Mental Contamination And Ptsd Symptoms In Survivors Of Sexual Trauma, Jesse P. Mccann

Theses and Dissertations--Psychology

Mental contamination–the experience of dirtiness or pollution in the absence of a physical contaminant–has established links with posttraumatic stress disorder (PTSD). Emotions such as shame and guilt have well-documented relationships with PTSD symptoms and are suggested to play a role in the development and maintenance of mental contamination. The goal of the present study was to examine whether trauma-related shame and guilt prospectively predicted daily experiences of mental contamination and PTSD symptoms among women with sexual trauma history. Forty-one women with a history of sexual trauma completed baseline and twice-daily assessments of mental contamination and PTSD symptoms over a two-week …

Impact Of Ptsd On Hcv/Hiv Risk-Reduction Interventions Among Incarcerated Drug-Using Women In Rural Appalachia, Caitlyn Hood

Theses and Dissertations--Psychology

Justice-involved women in rural Appalachian Kentucky are a particularly vulnerable group in need of targeted risk-reduction interventions for hepatitis C virus (HCV) and human immunodeficiency virus (HIV). Compared to women in the general U.S. population, justice-involved women in rural Appalachia report dramatically higher rates of HCV/HIV risk behaviors (e.g., injection drug use and risky sex), interpersonal violence (IV; e.g., physical, sexual, or emotional abuse), and posttraumatic stress disorder (PTSD). IV and PTSD may exacerbate rural Appalachian women’s risk for contracting and transmitting HIV/HCV, indicating a need to approach HCV/HIV risk-reduction interventions from a trauma-informed perspective.

Brief motivational interviewing and psychoeducation …

Altering The Distance: Using Construal Level Theory To Examine Conciliatory Policy Support, Brandon Reinkensmeyer

Theses and Dissertations--Psychology

Distancing—a cognitive reappraisal strategy—increases conciliatory policy support (i.e., policies redressing inequity) by reducing anger. Related but distinct research has used construal level theory (CLT), which explains the relationship between psychological distance and mental representations (e.g., events and attitudes), to explore intergroup relations. CLT demonstrates increased psychological distance induces abstract thinking, which leads to high-level construal (HLC) mindsets. HLC mindsets, like distancing, decrease political polarization and prejudice toward out-groups. As both distancing (an appraisal technique) and HLC mindsets (a potential outcome of appraisal techniques) may decrease political polarization and prejudice toward outgroups, across two experiments, the present work investigated whether …

Predicting Material Properties: Applications Of Multi-Scale Multiphysics Numerical Modeling To Transport Problems In Biochemical Systems And Chemical Process Engineering, Tom Pace

Theses and Dissertations--Physics and Astronomy

Material properties are used in a wide variety of theoretical models of material behavior. Descriptive properties quantify the nature, structure, or composition of the material. Behavioral properties quantify the response of the material to an imposed condition. The central question of this work concerns the prediction of behavioral properties from previously determined descriptive properties through hierarchical multi-scale, multiphysics models implemented as numerical simulations. Applications covered focus on mass transport models, including sequential enzyme-catalyzed reactions in systems biology, and an industrial chemical process in a common reaction medium.

Producing Possibilities: Envisioning And Mediating Youth, Identities, And Futures In Central Appalachia, Tammy Lynn Clemons

Theses and Dissertations--Anthropology

This dissertation, based on anthropological research between 2015 and 2020, focuses on young people in different yet interconnected social contexts in Central Appalachia and how they envision, construct, and act upon possibilities for themselves and the region through multimodal cultural production processes like visual art, performance, and multisensory media. The research question focusing this project was: How do the social contexts of young Appalachians’ engagement in media consumption and production practices shape the possibilities they envision for themselves, others, and their region? I found that the specific contexts were less important than the interconnected mentoring conversations across sites and generations …

Reimagining Care: Surviving And Thriving Among Lgbtq African Americans In Birmingham, Alabama, Stacie Lynn Hatfield

Theses and Dissertations--Anthropology

This dissertation draws on fieldwork with Black LGBTQ identifying individuals and communities in Birmingham, Alabama conducted from 2015-2019 as part of a project that reimagines theories of care. Informed by scholars of Black and feminist studies, I conceive of forms of care as negotiations of survival and tactics of thriving that are worked out in everyday practices and discourses among LGBTQ African Americans. I show how histories of racial inequality and centuries of resistance, surviving, and thriving among communities of African descent intersect with LGBTQ politics, space, and identity to create strategies and places of individual and community care. My …

Social Differentiation Among Rural Maya Households In Chunhuayum, Yucatan, Mexico, During The Late Preclassic Through The Early Classic (300 B.C. – A.D. 600), Céline Lamb

Theses and Dissertations--Anthropology

This dissertation addresses social differentiation among rural residents of Chunhuayum, an ancient Maya village in northwest Yucatan, from the Late Preclassic to the Late Early Classic (300 B.C. – A.D. 600/630). The three axes of social differentiation investigated are household wealth, occupation, and social connectivity to external networks. Using a practice theory approach, my research seeks to identify how material and social practices shaped and expressed social differentiation among Chunhuayum households, as well as how these may have shaped the particular history of Chunhuayum within its regional context. Throughout Chunhuayum’s occupation, residential architecture was the most salient marker of wealth …

Optical Metasurfaces, Fatih Balli

Theses and Dissertations--Physics and Astronomy

Traditional optical elements, such as refractive lenses, mirrors, phase plates and polarizers have been used for various purposes such as imaging systems, lithographic printing, astronomical observations and display technology. Despite their long-term achievements, they can be bulky and not suitable for miniaturization. On the other hand, recent nanotechnology advances allowed us to manufacture micro and nanoscale devices with ultra-compact sizes. Metasurfaces, 2D engineered artificial interfaces, have emerged as candidates to replace traditional refractive lenses with ultra-thin miniaturized optical elements. They possess sub-wavelength unit cell structures with a specific geometry and material selection. Each unit cell can uniquely tailor the phase, …

Woman To Woman: Community And Belonging Among Lesbian And Queer Feminist Activists In Haifa, Israel, Lauren Copeland

Theses and Dissertations--Gender and Women's Studies

This dissertation focuses on experiences of belonging among lesbian and queer feminist activist women in the women-only organization Isha L’Isha. As the oldest feminist organization in Israel, Isha L’Isha was established in 1983 and has roots dating back to the 1970s. I spent one year (2017-2018) engaging in participant observation and conducting 40 interviews with current and former members of the group. Using Isha L’Isha as a lens through which to examine the multilayered ways in which gendered activism shapes experiences of belonging, this project centers the experiences and narratives of four women: Talma, Sophie, Amira, and Maya.

This work …

Beyond Choice: An Intersectional Analysis Of Identity And Labor In Online Sex Work, Shawna F. Felkins

Theses and Dissertations--Gender and Women's Studies

This intersectional project seeks to understand the complex labor, social lives, and community building of online sex workers. Building on the work of foundational sex work researchers, this project utilizes in-depth interviews, a survey, social media posts, and published writing and research from online sex workers to understand how marginalization and identity impacts participation and success in online sex work. Providing analysis on how race, gender, class, and ability intersect in the digital sexual marketplace, this project critiques the rise of neoliberal feminism in sex work spaces that stems from the centering of white and otherwise privileged sex workers using …

Wisdom From The Collard Field: Exploring Agrarian Community In Twenty And Twenty-First Century American Literature, Robert M. Gorum

Theses and Dissertations--English

This dissertation surveys agrarian literature written by American writers since World War II. It compares the Southern Agrarians of Vanderbilt University and New Agrarians such as Wendell Berry, Wes Jackson, and Gene Logsdon to examine their understanding of place and home. I begin my inquiry with a personal frame story of time I have spent in and around the sustainable agriculture movement. Drawing on various forms of literature, including memoirs, cookbooks, novels, reportage, and other scholarship, I explore American ideals since World War II relating to the production and consumption of food.

I begin my opening chapter with a reassessment …

Biomechanics Of The Lower Back During Repetitive Deadlifts, With And Without Body Armor, Vanessa J. Ramirez

Theses and Dissertations--Kinesiology and Health Promotion

Background: Low back pain is a significant problem and one of the primary musculoskeletal-related conditions affecting active-duty service members [1]. Since more than two-thirds of U.S. soldier occupational tasks involve lifting from floor level to waist height [2], increasing individual lifting capacity is strongly correlated with performance with these tasks [3]. Training for the first Army Combat Fitness Test event (3RM deadlift) to improve lifting capacity directly relates to performing carrying/lifting military tasks. One training modality that can be used in training programs to improve lifting capacity is repetitions-to-failure (RTF) or repetitive lifting to volitional failure [4-8]. RTF is widely …

Comparison Of The Times To Exhaustion, Physiological, Perceptual, And Neuromusuclar Responses During Constant Heart Rate, Constant Vo2, And Constant Power Exercise, Pasquale Jiovanni Succi

Theses and Dissertations--Kinesiology and Health Promotion

The purposes of this study were to: 1) Determine if there are differences in the sustainability of exercise when anchored at critical heart rate (CHR), the VO₂ associated with CHR (VO₂CHR), or the power output associated with CHR (PCHR); 2) examine the patterns of responses in power output, metabolic (heart rate [HR], VO₂, respiration rate [RR]), neuromuscular (electromyographic [EMG] amplitude [AMP], mean power frequency [MPF], mechanomyographic [MMG] AMP and MPF, perceptual (rating of perceived exertion [RPE]), and muscle oxygenation responses (%SmO₂) during exercise anchored by HR, VO₂, and power output; and …

Examination Of Sex- And Limb-Specific Fatigue During Unilateral, Isometric Forearm Exercise, Caleb Christian Voskuil

Theses and Dissertations--Kinesiology and Health Promotion

The purpose of this study was to examine the effects of unilateral, isometric handgrip holds to failure for the dominant (Dm) and non-dominant (NDm) limb on ipsilateral ([IPS] exercised side) and contralateral ([CON] non-exercised side) performance fatigability. Twenty individuals participated in this study (Men [n =10]; Women [n = 10; Composite Demographics: Age: 22.2 years; Height: 174.4 cm; Body Mass: 75.0 kg) and completed three visits. Two, 6 s maximal voluntary isometric contractions (MVICs) for the Dm and NDm limb were performed during visit 1, followed by a familiarization of the fatigue test. Visits 2 and 3 included an isometric, …

Helping The Have-Nots: Examining The Relationship Between Rehabilitation Adherence And Self-Efficacy Beliefs In Acl Reconstructed Naia And Ncaa Dii And Diii Female Athletes, Myles Tutin Englis

Theses and Dissertations--Kinesiology and Health Promotion

Anterior cruciate ligament injuries are among the most common and traumatic sport-related injuries, and often negatively impact one’s quality of life during and post-rehabilitation. For many NCAA Division I and professional female athletes, rehabilitation is streamlined with a multidisciplinary team, including sport psychology. For others (e.g., NAIA, NCAA Division II, III athletes) this may not always be the case, as many of these athletic programs may not have the resources to meet the various needs of injured and rehabilitating female student-athletes. In these instances, rehabilitation motivation, adherence, and success may be more dependent on the athletes’ individual resources and personalities, …

Quadriceps Recruitment And Twitch Properties In Lean And Obese Women Before And After Fatiguing Exercise, Rebekah Seay Carpenter

Theses and Dissertations--Kinesiology and Health Promotion

Skeletal muscle strength, specifically that of the anti-gravitational muscles such as the quadriceps, is essential for performing dynamic tasks including walking, navigating stairs, and transitioning between sitting and standing. Obesity has been shown to negatively impact musculoskeletal function and decrease quadriceps strength relative to body weight. Additionally, obesity has been linked with higher rates of fatigue and lower strength outcomes following a test of muscular endurance of the quadriceps. Since obesity lowers relative strength, it is likely that quadriceps muscle weakness contributes to reduced physical function of dynamic tasks. However, to date, the precise mechanism for obesity-induced muscle weakness has …

The Acute Effect Of High Intensity Resistance Training On Subsequent Firefighter Performance, Mark Ryan Mason

Theses and Dissertations--Kinesiology and Health Promotion

High intensity resistance training (HIRT) is commonly performed by structural firefighters to enhance preparedness for occupational demands. Despite the potential for HIRT to induce beneficial adaptations over time, it is important to determine if a single on-duty HIRT session is detrimental to subsequent occupational physical ability due to exercise-induced fatigue. Therefore, the primary purpose of this study was to assess the acute effect of HIRT on occupational physical ability in structural firefighters and to determine the time course of recovery. The secondary purpose was to determine if timed completion of a standardized bout of HIRT was correlated to occupational performance …

Mechanical Deviations And Verbal-Cue Altered Gait In The Femoroacetabular Impingement Syndrome Population, Walter Menke

Theses and Dissertations--Kinesiology and Health Promotion

Femoroacetabular impingement syndrome (FAIS) is an abnormal physical hip morphology that causes functional changes and pain during gait. Mechanical gait differences in this population require further biomechanical investigation to elucidate characteristics unique to this group. Fixed speed gait trials were performed on force plates and analyzed in addition to isokinetic strength testing to find a multitude of biomechanical variables including joint moment, joint power, joint work, and peak joint angle. This work has discovered evidence of muscular deficits at the hip, specifically hip extension, as well as knee joint power contributions to gait when compared to controls. These findings suggest …

Quantification Of In-Play Competition Demands Of Collegiate American Football Players Using Global Positioning Systems, Alex Brownell

Theses and Dissertations--Kinesiology and Health Promotion

There is limited information describing the competition demands of American football. A greater understanding of competition demands will allow strength and conditioning practitioners to create appropriate training programs to enhance athlete readiness and performance. Therefore, the purpose of this study was to analyze the competition demands of collegiate American football players using global positioning systems (GPS), specifically comparing the in-play GPS versus out-of-play GPS outcomes. Twenty-two American football athletes (Age: 20.8 ± 0.9 yr, Height: 190.2 ± 4.7 cm, Body mass: 113.4 ± 22.3 kg) were monitored during 12 regular season competitions over 13 weeks. Athletes were divided into specific …

Gender In The Time Of Covid-19: Evaluating National Leadership And Covid-19 Fatalities, Leah C. Windsor, Gina Yannitell Reinhardt, Alistair J. Windsor, Robert Ostergard, Susan Allen, Courtney Burns, Jarod Giger, Reed Wood

Social Work Faculty Publications

In this paper we explore whether countries led by women have fared better during the COVID-19 pandemic than those led by men. Media and public health officials have lauded the perceived gender-related influence on policies and strategies for reducing the deleterious effects of the pandemic. We examine this proposition by analyzing COVID-19-related deaths globally across countries led by men and women. While we find some limited support for lower reported fatality rates in countries led by women, they are not statistically significant. Country cultural values offer more substantive explanation for COVID-19 outcomes. We offer several potential explanations for the pervasive …

Dach1 Mutation Frequency In Endometrial Cancer Is Associated With High Tumor Mutation Burden, Mckayla J. Riggs, Nan Lin, Chi Wang, Dava W. Piecoro, Rachel W. Miller, Oliver A. Hampton, Mahadev Rao, Frederick R. Ueland, Jill M. Kolesar

Obstetrics and Gynecology Faculty Publications

OBJECTIVE: DACH1 is a transcriptional repressor and tumor suppressor gene frequently mutated in melanoma, bladder, and prostate cancer. Loss of DACH1 expression is associated with poor prognostic features and reduced overall survival in uterine cancer. In this study, we utilized the Oncology Research Information Exchange Network (ORIEN) Avatar database to determine the frequency of DACH1 mutations in patients with endometrial cancer in our Kentucky population.

METHODS: We obtained clinical and genomic data for 65 patients with endometrial cancer from the Markey Cancer Center (MCC). We examined the clinical attributes of the cancers by DACH1 status by comparing whole-exome sequencing (WES), …

3-In-1 Hybrid Learning Environment, Holly Hapke, Anita Lee-Post, Tereza Dean

Marketing & Supply Chain Faculty Publications

We propose a learning innovation called 3-in-1 Hybrid environment as a solution for educational institutions to meet the challenge of balancing campus reopening against public health risks amid the COVID-19 pandemic. Our proposed innovation provides students options to attend class synchronously (either face-to-face or remote) or asynchronously (online) in an interactive learning environment that promotes emotional, behavioral, and cognitive engagement. We designed and implemented a large Marketing Management class with over 800 students as a 3-in-1 course. We examined its effectiveness in an empirical study and found that (1) students have a positive attitude toward 3-in-1 Hybrid learning; (2) they …

Recovery Of Hippocampal-Dependent Learning Despite Blunting Reactive Adult Neurogenesis After Alcohol Dependence, Chelsea G. Nickell, K. Ryan Thompson, James R. Pauly, Kimberly Nixon

Pharmaceutical Sciences Faculty Publications

Background:

The excessive alcohol drinking that occurs in alcohol use disorder (AUD) causes neurodegeneration in regions such as the hippocampus, though recovery may occur after a period of abstinence. Mechanisms of recovery are not clear, though reactive neurogenesis has been observed in the hippocampal dentate gyrus following alcohol dependence and correlates to recovery of granule cell number.

Objective:

We investigated the role of neurons born during reactive neurogenesis in the recovery of hippocampal learning behavior after 4-day binge alcohol exposure, a model of an AUD. We hypothesized that reducing reactive neurogenesis would impair functional recovery.

Methods:

Adult male rats were …

Diverse And Complex Muscle Spindle Afferent Firing Properties Emerge From Multiscale Muscle Mechanics, Kyle P. Blum, Kenneth S. Campbell, Brian C. Horslen, Paul Nardelli, Stephen N. Housley, Timothy C. Cope, Lena H. Ting

Physiology Faculty Publications

Despite decades of research, we lack a mechanistic framework capable of predicting how movement-related signals are transformed into the diversity of muscle spindle afferent firing patterns observed experimentally, particularly in naturalistic behaviors. Here, a biophysical model demonstrates that well-known firing characteristics of mammalian muscle spindle Ia afferents – including movement history dependence, and nonlinear scaling with muscle stretch velocity – emerge from first principles of muscle contractile mechanics. Further, mechanical interactions of the muscle spindle with muscle-tendon dynamics reveal how motor commands to the muscle (alpha drive) versus muscle spindle (gamma drive) can cause highly variable and complex activity during …