Digital Commons Network^™

Deposition Of Nanoparticles On School Eyeglasses In Urban And Rural Areas: A Methodology For A More Real Assessment Of The Possible Impacts, Ḱtia Martinello, James C. Hower, Guilherme L. Dotto, Claudete Gindri Ramos, Carlos E. Schnorr, Diana Pinto

Earth and Environmental Sciences Faculty Publications

Because incomplete confirmation is available concerning the influential role of atmosphere contamination on conjunctivitis, myopia, asthma, and allergic rhinitis in Brazil, the focus of the present work is to explore the possible relations among atmosphere contamination and eye problems. Rather that a case study on eye diseases, by way of questionnaires supplemented by the investigation of nanoparticles (NPs) on eyeglasses, the study examines the mechanisms in which NPs and ultra-fine particles are deposited on the glasses of children up to 10 years of age in urban and rural area. The important connection between atmosphere contaminants and individual protection equipment justifies …

Identifying And Solving Mineral Deficiencies In Sheep And Goats In Inner Mongolia, Adrian Williams, Dunyuan Hao

IGC Proceedings (1977-2023)

No abstract provided.

2020 Kentucky Nursing Workforce Report, Sydney P. Thompson

Center of Excellence in Rural Health Infographics

No abstract provided.

Why Won’T Grandma Cross The Road? Neighborhood Perceptions And Walking Behavior Among Older Adults In Lexington, Kentucky, Sadie Middleton

Theses and Dissertations--Urban and Environmental Design

Many urban places contain subtle details that can unintentionally deter pedestrian activity. These details can be assessed through six themes: safety, comfort, pedestrian infrastructure, aesthetics, proximity, and ease of navigation. Adults over age 65 may have more concerns about walking in urban settings than people in other age groups. This study identifies urban design elements that encourage and discourage walking among older adults and makes recommendations for design improvements. Study participants (n= 67) completed an online survey about walking behaviors, perceptions of health and community, and perceptions of seven unidentified scenes of pedestrian environments in Lexington, Kentucky. Findings suggest that …

Southeastern Law Librarian Winter 2021, Seaall

Newsletters

No abstract provided.

The Glass Is Half Full But Contaminated: An Analysis Of The United States’ Financial Investment In The Drinking Water Infrastructure System, Maya Marshall

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Magnetic Resonance And Ct Imaging Biomarkers For Prediction Of Acute And Chronic Radiation-Induced Xerostomia, Anastasia Katsavochristou, Dimitrios Koumoulis

Oral Health Practice Faculty Publications

Xerostomia is a common adverse effect of radiation therapy at the head and neck area. Radiation-induced xerostomia can be severe and detrimental for the quality of life. Clinicians and radiologists have focused on the prevention of xerostomia as feasible, which has been significantly improved in the recent decades with the use of the contemporary radiation technology. However, radiation-induced xerostomia still remains one of the most devastating side effects of radiation therapy. Clinical risk factors have been identified, but the variation of its incidence and presentation has turned the focus on the investigation of parameters that would be able to predict …

A Burning River: Why New Directives May Signal A Continuance In The Downfall Of The Ohio River, Vincent G. Kleindienst

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

A Methodology For Autonomous Roof Bolt Installation Using Industrial Robotics, Anastasia Xenaki

Theses and Dissertations--Mining Engineering

The mining sector is currently in the stage of adopting more automation, and with it, robotics. Autonomous bolting in underground environments remains a hot topic for the mining industry. Roof bolter operators are exposed to hazardous conditions due to their proximity to the unsupported roof, loose bolts, and heavy spinning mass. Prolonged exposure to the risk inevitably leads to accidents and injuries.

The current thesis presents the development of a robotic assembly capable of carrying out the entire sequence of roof bolting operations in full and partial autonomous sensor-driven rock bolting operations to achieve a high-impact health and safety intervention …

Effect Of Blood Flow Restriction Training On Functional And Self-Reported Outcomes In Female Runners With Patellofemoral Pain, Lauren Nicole Erickson

Theses and Dissertations--Rehabilitation Sciences

Background: Patellofemoral pain (PFP) is the leading cause of lower extremity injury in female runners, significantly limiting running ability and becoming chronic in nearly 50% of the cases. This condition, which presents as pain around (peripatellar) or behind (retropatellar) the patella, is associated with significant weakness of the quadriceps and gluteal musculature, as well as altered movements mechanics. The challenge for clinicians is designing an effective treatment program to reduce pain and improve function without causing symptoms to flare. Blood flow restriction training (BFRT) is a relatively new training method within rehabilitation that involves placing a pressurized cuff to the …

Metaphor And The Struggle Between Populism And Liberal Democracy, Daniel Cole

Theses and Dissertations--Philosophy

Populist movements have emerged the world over, appearing even in countries in which it had long been assumed that liberal democracy was unassailable. Scholars have been grappling with the concept of populism for decades, but as populists have won victories close to home, the research has taken on a heightened sense of urgency. Two of the common theses that have appeared in the recent literature are, (a) populism is opposed to liberal democracy, and (b) populism is linked to a democratic tradition of thought that originates with Rousseau. While I am willing to grant (a), I argue in this dissertation …

Maternal Proximity To Mountaintop Removal Mining And Birth Defects In Appalachian Kentucky, 1997-2003, Daniel B. Cooper

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Background: Extraction of coal through mountaintop removal mining (MTR) alters many dimensions of the landscape, and explosive blasts, exposed rock, and coal washing have the potential to pollute air and water with substances known to increase risk of developmental and birth anomalies. Previous research suggests that infants born to mothers living in MTR coal mining counties have higher prevalence of most types of birth defects.

Objectives: This study seeks to examine further the relationship between MTR activity and birth defects by employing individual level exposure estimation through precise satellite data of MTR activity in the Appalachian region and maternal residence …

Patient Engagement In Patient Portals In Appalachia Versus Surrounding Us Census Regions: An Analysis Of Hints (Health Information National Trends Survey) Data, 2017 - 2020, Heather Lea Tudor

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

OBJECTIVE: Those living in the Appalachian regions face more significant healthcare disparities than those in the US. Patient portals can decrease disparities and increase health outcomes and health literacy. The purpose of this study was to determine if those living in the Appalachian region were offered access to and used their patient portals differently than the surrounding US Census region. Additionally, we aimed to determine if there was a difference in reported reasons for non-use of patient portals.

METHODS: This was a descriptive study using data from the National Cancer Institute’s Health Information National Trends Survey (HINTS) data (2017-2020) to …

Racial Disparities In Syringe Exchange Program Access In Kentucky, Ankur Bhargava

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Non-white Kentuckians use syringe exchange programs (SEPs) at lower rates than white Kentuckians. This analysis begins by documenting this disparity and then explores several potential causes. Access to SEPs is limited by law as only health departments may operate them. Areas of the state in which SEPs face political opposition are therefore underserved. A consequence of this legal limitation is distance to a SEP may be a barrier to access. Analysis of publicly available data indicates non-white drug users in Kentucky are located closer to syringe exchange programs in urban areas but farther away in rural areas. Proximity to a …

The Witness Project In Whitehall, Oh, Freda Allyson Hucek

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Abstract

The Witness Project (WP) is an evidence-based breast cancer screening intervention that will be implemented in Whitehall, Ohio, at three different churches by the Franklin County Health Department. The WP will target African American women 50-74 years old who are non-compliant with current United States Preventative Services Task Force (USPSTF) breast cancer screening recommendations. African American women face disproportionately higher mortality rates from breast cancer when compared to other racial and ethnic groups in the United States and in Whitehall. African American women are less likely to discuss breast cancer and preventive screening services within their community. The WP …

“I Knew I Wanted More For Myself”: Sexual Minority Men’S Narratives About Getting Help For Intimate Partner Violence, Jonathan Ryser-Oatman

Theses and Dissertations--Educational, School, and Counseling Psychology

Sexual minority men experience intimate partner violence (IPV) at rates similar to, if not higher, than heterosexual individuals (Finneran & Stephenson, 2013). IPV is associated with a range of negative health outcomes in this population, such as increased risk for depression and anxiety (Miller & Irvin, 2017) and increased sexual risk-taking and subsequent HIV acquisition (Craft & Serovich, 2005; Houston & McKirnan, 2007). Many barriers prevent sexual minority men from getting help for IPV including stigma-related stressors, socioeconomic status, HIV status, perceived lack of helping resources, and a lack of knowledge about IPV (Duke & Davidson, 2009; Edwards, Sylaska, & …

When Worlds Collide: An Intersectional Approach To Understanding The Relationship Experiences Of Bisexual-Identifying Asian Men With Same And Different Gender Partners, Cheryl Kwok

Theses and Dissertations--Educational, School, and Counseling Psychology

The relationship experiences of bisexual-identifying men of color have been neglected in psychological studies of race, gender, and sexuality. Few studies, if any, have examined the relationship experiences of Asian bisexual men, even though this population’s multiple marginalized and stigmatized social identities increase their health risks (Bryant-Davis, 2007; Carter, 2007; Ching et al., 2018). Bisexuality is commonly defined by an individual’s intimate partner attraction and/or behavior (e.g., Swan & Habibi, 2018), making relationship experiences fundamental to bisexual identity. More generally, intimate relationships can contribute to and/or pose challenges to psychological well-being (Feinstein, et al., 2016; Whitton et al., 2018), yet …

Framing Early Adolescents’ Self-Efficacy Development: Precursors To The Sources Of Math Self-Efficacy, Calah J. Ford

Theses and Dissertations--Educational, School, and Counseling Psychology

Self-efficacy, the beliefs learners hold about what they can do, develops largely from how learners perceive and interpret four main sources of information: mastery experiences, vicarious experiences, social persuasions, and physiological states. Although researchers have shown a relationship between these sources and math self-efficacy, less is known about the factors that may influence how early adolescent learners perceive and interpret information from these sources. The purpose of this dissertation was to investigate two possible factors (i.e., perfectionism, performance-related factors) that might predict how learners perceive efficacy-relevant information in the domain of math. Study 1 used a correlational design to investigate …

The Political Consequences Of State Action On Violence Against Women: How Victims And Non-Victims Form Opinions About Government, Helen Rabello Kras

Theses and Dissertations--Political Science

This dissertation examines the impact of public policies designed to prevent, address, and punish violence against women (VAW) on citizens’ political attitudes as well as news coverage in Brazil. Despite being politically important, these topics are understudied, particularly in the context of Latin America. In the dissertation, I investigate the following research questions: 1) How does government attention to gender-based violence shape news media coverage of violence against women? 2) How do policies on violence against women shape intimate partner violence survivors’ political attitudes? 3) How do encounters with the police shape survivors’ political opinions and bystander intervention attitudes? By …

Epigenetic States Regulate Tumor Aggressiveness And Response To Targeted Therapies In Lung Adenocarcinoma, Fan Chen

Theses and Dissertations--Toxicology and Cancer Biology

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, 85% of which are lung adenocarcinomas (LUAD). Although molecular studies of NSCLC identified targetable mutations of some oncogenes including BRAF, EGFR and ALK, no targeted therapies exist for most cases. Cancer epigenetics is the study of epigenetic modifications, including histone modifications, that control gene expression in cancer. Recent advances have revealed numerous epigenetic abnormalities in human cancers, and targeting epigenetic regulators could be effective at reversing dysregulated epigenetic programs or driving sensitivity to other targeted therapies.

Inhibitors of the histone methyltransferase EZH2 have recently been approved as …

The Tumor Suppressor Par-4 Regulates Hypertrophic Obesity, Nathalia Araujo

Theses and Dissertations--Toxicology and Cancer Biology

Prostate Apoptosis Response-4 (Par-4) is a tumor suppressor ubiquitously expressed in all tissues and able to selectively induce apoptosis in cancer cells. Although well established in the context of cancer, relatively little is known about the function of Par-4 in the healthy and non-tumorigenic context. Observations from our lab showed that Par-4 knockout mouse lines were obese and displayed adipocyte hypertrophy under a normal chow diet when compared to Par-4 wild-type mice. These Par-4 knockout mice exhibited hepatic steatosis and hyperinsulinemia as secondary consequences of obesity. Par-4 knockout mice displayed increased intestinal dietary fat absorption and its subsequent storage in …

Mechanisms Of Cadmium-Induced And Epidermal Growth Factor Receptor Mutation-Driven Lung Tumorigenesis, Hsuan-Pei Lin

Theses and Dissertations--Toxicology and Cancer Biology

Cadmium (Cd) is a ubiquitous pollutant in the environment and a known carcinogen for lung cancer. Cd has been shown to act as a weak mutagen, which suggests that it may exert tumorigenic effect through non-genotoxic ways, such as epigenetic mechanisms. The goal of this project is to investigate the mechanisms of Cd carcinogenesis focusing on the role of lncRNA dysregulations. The Cd-exposed cells formed significantly more colonies in soft agar, displayed cancer stem cell (CSC)-like property and formed tumors in nude mice. Mechanistically, the lncRNA microarray analysis revealed that chronic Cd exposure dysregulates lncRNA expressions. Q-PCR analysis confirmed the …

Delineating The Role Of Fatty Acid Metabolism To Improve Therapeutic Strategies For Colorectal Cancer, James Drury

Theses and Dissertations--Toxicology and Cancer Biology

Colorectal cancer (CRC) remains a leading cause of cancer-related deaths in the world, comprising over 1 million new cases each year and over 500,000 deaths. CRC, when detected at an early stage of disease development, can be effectively treated, with a 5-year survival rate of over 90%. Such standard treatments include surgical resection of the primary tumor in combination with adjuvant chemotherapy. However, even with advancements in surgical procedures and chemotherapeutic targets, when CRC progresses to a more advance stage, the 5-year survival rate decreases significantly to just under 14%. This stark decrease in patient survival rate can be directly …

Science-Based Regulation Of Pharmacological Substances In Competition Horses, Jacob Machin

Theses and Dissertations--Toxicology and Cancer Biology

Current testing methodologies within equine forensic toxicology focus on arbitrary thresholds and zero-tolerance policy. Modern analytical chemistry’s limits of detection are low enough that oftentimes femtogram-per-milliliter amounts of a substance can readily be identified in both blood and urine of a horse. For most pharmacologically relevant compounds, these concentrations have no relevance to pharmacological effect. It is therefore crucial that testing methodologies to determine appropriate thresholds and cut-offs be developed that are driven by biological activity rather than arbitrary limits of detection. This dissertation looks to address this by suggesting a system of calculated Effective Plasma Concentrations by which a …

Development Of Tools For Atom-Level Interpretation Of Stable Isotope-Resolved Metabolomics Datasets, Huan Jin

Theses and Dissertations--Toxicology and Cancer Biology

Metabolomics is the global study of small molecules in living systems under a given state, merging as a new ‘omics’ study in systems biology. It has shown great promise in elucidating biological mechanism in various areas. Many diseases, especially cancers, are closely linked to reprogrammed metabolism. As the end point of biological processes, metabolic profiles are more representative of the biological phenotype compared to genomic or proteomic profiles. Therefore, characterizing metabolic phenotype of various diseases will help clarify the metabolic mechanisms and promote the development of novel and effective treatment strategies.

Advances in analytical technologies such as nuclear magnetic resonance …

A Global Pandemic's Effect On The Retail Industry, Sabriyah Arain

Lewis Honors College Capstone Collection

It is commonly known that the effects of the COVID-19 pandemic have impacted many industries, including healthcare, transportation, and leisure to name a few. One particular industry that seems to have been greatly affected is retail. With many individuals deciding to stay safe at home rather than go out shopping, this poses a question regarding how retail companies are changing their selling and promotional strategies. It is apparent that online shopping has become more popular. However, what may be less apparent is how retail stores are adapting. With fewer customers entering the stores, it is important to look into what …

An Exploration Of Sleep Fragmentation And Sleep Enhancement In Mice, Frannie Salisbury

Lewis Honors College Capstone Collection

Alzheimer’s Disease (AD) is a neurodegenerative disease that is can be defined by amyloid beta (Aβ) plaques, neurofibrillary tangles, and neuronal death. AD patients have characteristically fragmented sleep, with frequent nighttime awakenings and daytime naps. Decreased clearance of Aβ from disrupted sleep may be a contributing factor in the progression of AD. This study investigated how sleep fragmentation effected the progression of AD in 3xTgAD mice. Results showed that sleep fragmented mice had significantly more Aβ build-up in the hippocampus and thus greater progression of AD when compared to control mice. Improving sleep may be one way to reduce the …

Biofilm And Cell Adhesion Strength On Dental Implant Surfaces Via The Laser Spallation Technique, James D. Boyd, Arnold J. Stromberg, Craig S. Miller, Martha E. Grady

Statistics Faculty Publications

OBJECTIVE: The aims of this study are to quantify the adhesion strength differential between an oral bacterial biofilm and an osteoblast-like cell monolayer to a dental implant-simulant surface and develop a metric that quantifies the biocompatible effect of implant surfaces on bacterial and cell adhesion.

METHODS: High-amplitude short-duration stress waves generated by laser pulse absorption are used to spall bacteria and cells from titanium substrates. By carefully controlling laser fluence and calibration of laser fluence with applied stress, the adhesion difference between Streptococcus mutans biofilms and MG 63 osteoblast-like cell monolayers on smooth and rough titanium substrates is obtained. The …

Rwanda’S Coffee Industry: Colonialism And The Impact Of Fair Trade Coffee, Sydney Daniels

Oswald Research and Creativity Competition

Undoubtedly, coffee is a treasured commodity shared by people across the globe. One country where coffee takes a particular importance is in Rwanda, a land-locked country in Sub-Saharan Africa. Historical evidence suggests that colonization centered on gaining access to the economic rents produced by the coffee agricultural sector which deepened Rwandan economic and social divides. Following the 1994 Rwandan Genocide, the national coffee industry was restructured to transition to premium, Fair Trade grade coffee. An increase in the number of coffee cooperatives provided opportunities for decreasing ethnic tension and for women to join the labor force. However, the economic impact …

Commentary: Use Of Bactrac Proteomic Database-Uromodulin Protein Expression During Ischemic Stroke, Gabriella-Salome K. Armstrong, Jacqueline A. Frank, Christopher J. Mclouth, Ann M. Stowe, Jill M. Roberts, Amanda L. Trout, Justin F. Fraser, Keith R. Pennypacker

Neurology Faculty Publications

Introduction: Uromodulin (UMOD) is a glycoprotein expressed by the epithelial cells of the thick ascending limb of Henle's loop in the kidney. Research has shown that increased uromodulin expression may be associated with lower risk of cardiovascular disease in adults. Utilizing the Blood and Clot Thrombectomy Registry and Collaboration (BACTRAC) (clinicaltrials.gov NCT03153683), a continuously enrolling tissue bank, we aimed to examine the associations between serum uromodulin, age, and high BMI (BMI> 25) and its relationship to stroke in patients.

Methods: Arterial blood distal and proximal to the thrombus was collected during a thrombectomy procedure using the BACTRAC protocol and sent …